CN105596577A - Traditional Chinese medicine preparation for treating onychomycosis and preparation method and application thereof - Google Patents
Traditional Chinese medicine preparation for treating onychomycosis and preparation method and application thereof Download PDFInfo
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- CN105596577A CN105596577A CN201610009452.5A CN201610009452A CN105596577A CN 105596577 A CN105596577 A CN 105596577A CN 201610009452 A CN201610009452 A CN 201610009452A CN 105596577 A CN105596577 A CN 105596577A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating onychomycosis and a preparation method and application thereof. The traditional Chinese medicine preparation is prepared from, by weight, 36-46 parts of radix tinosporae, 22-29 parts of radix tetrastigme and 15-25 parts of belvedere fruits. The radix tinosporae is subjected to crushing, extraction, concentration and spray drying to obtain radix tinosporae powder; the radix tetrastigme and the belvedere fruits are subjected to crushing, anhydrous ethyl alcoholsoaking, decoction and concentration, and concentration continues to condense the mixture into an extract after the radix tinosporae powder is added, namely the traditional Chinese medicine preparation is obtained. The traditional Chinese medicine preparation adopts the pure traditional Chinese medicines, is simple and reasonable in formula, wide in raw material source, low in cost, simple in preparation process and easy to operate, is used for treating the onychomycosis, has the advantages of being quick to infiltrate, good in bactericidal activity, short in medication time, convenient to use, free of pain and side effects and high in cure rate, enabling the onychomycosis not to easily relapse and the like and is suitable for industrialized production.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine preparation for the treatment of onychomycosis and its preparation method and application.
Background technology
Onychomycosis (onychomycosis) is the finger (toe) being caused by dermatophyte, saccharomycete and non-dermatophyte filamentous fungi (mould)First infects. The onychonosus only being caused by dermatophyte infection deck is called onychomycosis (tineaunguium). Toenail tinea is mostly by footTinea is directly propagated, and nail tinea may be propagated or because of the sick directly contact infection of the tinea at other positions of health of scratching by the tinea manuum. VeryBacterium infects and causes nail structure to change, color change, and a kind of fungal dermatopathy mutually infecting, cause nail distortion,Thicken, easily come off, separate, often have one to cause multiple nails infected. The traditional Chinese medical science is called curled paralysis, tinea etc.,Mostly be tinea of feet and hands and with the passing of time spread, so that due to day not flourish first. According to the different clinical characters of first infringement, onychomycosis can be divided intoFollowing four types: onychomycosis (distalsubungualonychomycosis, DSO) under far-end first, the shallow first of white table are trueOnychomycosis (proximalsubungual under bacterium disease (whitesuperficialonychomycosis, WSO), near-end firstOnychomycosis, PSO), full dystrophic onychomycosis (totaldystrophiconychomycosis, TDO).
Onychomycosis disease is the disease that a kind of refractory is healed, and at present, in treatment, has oral medicine and externally applied drug two classes, Oral antifungal agentsThing, as Itraconazole, Fluconazole, this class medicine has certain injury to liver. Externally applied drug Western medicine class have whitfield ointment,Miconazole creme, compound thunder are locked pungent preparation etc., and this class medicine kills dermatophyte effect, but medicine irritation is strong, has and is difficult toThe pain of standing and curing the symptoms, not the disease, recurrence rate is high. In recent years Chinese medicine class externally applied drug day by day increases, and external Chinese medicament is generally depositedThe defects such as, treatment time high at cost is long.
Summary of the invention
The object of the present invention is to provide a kind of quick permeation, bactericidal properties is strong, administration time is short, easy to use, no pain, nothingSide effect, cure rate Chinese medicine preparation high, the treatment onychomycosis of difficult recurrence more afterwards and its preparation method and application, to solveThe problem proposing in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
Treat a Chinese medicine preparation for onychomycosis, by forming according to the raw material of weight portion below: tinosporae 36-46 part, three leavesBlue or green 22-29 part, fruit of summer cypress 15-25 part.
As the further scheme of the present invention: the Chinese medicine preparation of described treatment onychomycosis, by following according to the raw material group of weight portionBecome: tinosporae 39-43 part, radix tetrastigme 25-28 part, fruit of summer cypress 18-22 part.
As the further scheme of the present invention: the Chinese medicine preparation of described treatment onychomycosis, by following according to the raw material group of weight portionBecome: 42 parts of tinosporaes, 27 parts of radix tetrastigmes, 19 parts of the fruit of summer cypress.
The preparation method of the Chinese medicine preparation of described treatment onychomycosis, is made up of following steps:
1) after tinosporae cleaning, insert defibrination pulverizer and pulverize, add the water of 4-5 times of quality of tinosporae quality to mixSqueeze into pot for solvent extraction with pump afterwards; In pot for solvent extraction, add cellulase, obtain tinosporae leaching liquor; Wherein adding of its cellulaseAmount is 0.6-0.7U/g, 55 DEG C of extraction temperatures, and extraction time is 1.1-1.2h; By tinosporae leaching liquor by decompression distillationMode concentrated, be concentrated into the 15-18% of original volume, make tinosporae concentrate; Tinosporae concentrate is sprayed dry,Obtain tinosporae powder;
2) radix tetrastigme, the fruit of summer cypress are crushed to 80-100 order after cleaning, then add the two weight 7-8 absolute ethyl alcohol doubly,Under 60-65 DEG C, air-proof condition, stir and soak 5-6h, then decoct 10-15min, then add the two weight 7-8 doublyAbsolute ethyl alcohol continue to decoct 0.5-0.7h, after filtration the first filtrate, to adding doubly anhydrous of the two weight 3-4 in filter residueEthanol decocts 20-30min, filters to obtain the second filtrate, merges twice filtrate, concentrated by the mode of decompression distillation, concentratedTemperature is 47 DEG C, is concentrated into the 30-40% of original volume, then adds tinosporae powder, continues to be condensed into medicinal extract and obtains treatment ashThe Chinese medicine preparation of nail.
The application of described Chinese medicine preparation in the medicine of preparation treatment onychomycosis.
Tinosporae in the present invention, Chinese medicine name. The dried root of menispermaceous plants limacia sagittata or tinosporae. Autumn, two seasons of winter excavate,Remove fibrous root, clean, dry. Nature and flavor bitter cold, have clearing heat and detoxicating, relieve sore throat, effect of pain relieving. For abscess of throat, carbuncleSubcutaneous ulcer serious case of furuncle, has loose bowels, dysentery, epigastric pain.
Radix tetrastigme property is flat, mildly bitter flavor, has the effects such as clearing heat and detoxicating, dispelling pathogenic wind and eliminating phlegm, promoting blood circulation and stopping pain, cure mainly venomous snake bite,The diseases such as tonsillitis, scrofula, traumatic injury, children with high fever induced convulsions.
Fruit of summer cypress clearing heat and promoting diuresis, dispellings wind and arresting itching. For difficulty and pain in micturition, under pruritus vulvae band, rubella, eczema, pruitus.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention adopts pure Chinese medicine, and formula is simple, rationally, and raw material is drawn materials extensively, cost is low, and preparation process simply, easily graspDo, treatment onychomycosis has quick permeation, bactericidal properties is strong, administration time is short, easy to use, no pain, have no side effect, controlMore rate high, be difficult for the features such as recurrence more afterwards, be suitable for suitability for industrialized production.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, aobviousSo, described embodiment is only the present invention's part embodiment, instead of whole embodiment. Based in the present inventionEmbodiment, those of ordinary skill in the art are not making the every other embodiment obtaining under creative work prerequisite, allBelong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of Chinese medicine preparation for the treatment of onychomycosis, by forming according to the raw material of weight portion below: Jin Guo36 parts of olives, 22 parts of radix tetrastigmes, 15 parts of the fruit of summer cypress.
Tinosporae is inserted defibrination pulverizer and pulverizes after cleaning, and uses pump after adding the water of 4 times of quality of tinosporae quality to mixSqueeze into pot for solvent extraction; In pot for solvent extraction, add cellulase, obtain tinosporae leaching liquor; Wherein the dosage of its cellulase is0.6U/g, 55 DEG C of extraction temperatures, extraction time is 1.1h; Tinosporae leaching liquor is concentrated by the mode of decompression distillation,Be concentrated into 15% of original volume, make tinosporae concentrate; Tinosporae concentrate is sprayed dry, obtain tinosporae powderEnd. After radix tetrastigme, the fruit of summer cypress are cleaned, be crushed to 80 orders, then add the absolute ethyl alcohol of 7 times of the two weight, 60 DEG C,Under air-proof condition, stir and soak 5h, then decoct 10min, then add the absolute ethyl alcohol of 7 times of the two weight to continue to decoct0.5h, after filtration the first filtrate, decoct 20min to the absolute ethyl alcohol that adds 3 times of the two weight in filter residue, filter theTwo filtrates, merge twice filtrate, and the mode by decompression distillation is concentrated, concentrated temperature is 47 DEG C, are concentrated into original volume30%, then add tinosporae powder, continue to be condensed into medicinal extract and obtain the Chinese medicine preparation for the treatment of onychomycosis.
Embodiment 2
In the embodiment of the present invention, a kind of Chinese medicine preparation for the treatment of onychomycosis, by forming according to the raw material of weight portion below: Jin Guo46 parts of olives, 29 parts of radix tetrastigmes, 25 parts of the fruit of summer cypress.
Tinosporae is inserted defibrination pulverizer and pulverizes after cleaning, and uses pump after adding the water of 5 times of quality of tinosporae quality to mixSqueeze into pot for solvent extraction; In pot for solvent extraction, add cellulase, obtain tinosporae leaching liquor; Wherein the dosage of its cellulase is0.7U/g, 55 DEG C of extraction temperatures, extraction time is 1.2h; Tinosporae leaching liquor is concentrated by the mode of decompression distillation,Be concentrated into 18% of original volume, make tinosporae concentrate; Tinosporae concentrate is sprayed dry, obtain tinosporae powderEnd. After radix tetrastigme, the fruit of summer cypress are cleaned, be crushed to 100 orders, then add the absolute ethyl alcohol of 8 times of the two weight, 65 DEG C,Under air-proof condition, stir and soak 6h, then decoct 15min, then add the absolute ethyl alcohol of 8 times of the two weight to continue to decoct0.7h, after filtration the first filtrate, decoct 30min to the absolute ethyl alcohol that adds 4 times of the two weight in filter residue, filter theTwo filtrates, merge twice filtrate, and the mode by decompression distillation is concentrated, concentrated temperature is 47 DEG C, are concentrated into original volume40%, then add tinosporae powder, continue to be condensed into medicinal extract and obtain the Chinese medicine preparation for the treatment of onychomycosis.
Embodiment 3
In the embodiment of the present invention, a kind of Chinese medicine preparation for the treatment of onychomycosis, by forming according to the raw material of weight portion below: Jin Guo39 parts of olives, 25 parts of radix tetrastigmes, 18 parts of the fruit of summer cypress.
Tinosporae is inserted defibrination pulverizer after cleaning and pulverizes, and adds the water of 4.5 times of quality of tinosporae quality to mix rear usePump is squeezed into pot for solvent extraction; In pot for solvent extraction, add cellulase, obtain tinosporae leaching liquor; Wherein the dosage of its cellulase is0.65U/g, 55 DEG C of extraction temperatures, extraction time is 1.15h; Tinosporae leaching liquor is concentrated by the mode of decompression distillation,Be concentrated into 16% of original volume, make tinosporae concentrate; Tinosporae concentrate is sprayed dry, obtain tinosporae powderEnd. After radix tetrastigme, the fruit of summer cypress are cleaned, be crushed to 90 orders, then add the absolute ethyl alcohol of 7.5 times of the two weight, 62 DEG C,Under air-proof condition, stir and soak 5.5h, then decoct 12min, then add the two weight 7-8 absolute ethyl alcohol doubly to continueDecoct 0.6h, after filtration, obtain the first filtrate, in filter residue, add the absolute ethyl alcohol of 3.5 times of the two weight to decoct 25min, mistakeFilter to obtain the second filtrate, merge twice filtrate, concentrated by the mode of decompression distillation, concentrated temperature is 47 DEG C, is concentrated into former35% of volume, then add tinosporae powder, continue to be condensed into medicinal extract and obtain the Chinese medicine preparation for the treatment of onychomycosis.
Embodiment 4
In the embodiment of the present invention, a kind of Chinese medicine preparation for the treatment of onychomycosis, by forming according to the raw material of weight portion below: Jin Guo43 parts of olives, 28 parts of radix tetrastigmes, 22 parts of the fruit of summer cypress.
Preparation process is consistent with embodiment 3.
Embodiment 5
In the embodiment of the present invention, a kind of Chinese medicine preparation for the treatment of onychomycosis, by forming according to the raw material of weight portion below: Jin Guo42 parts of olives, 27 parts of radix tetrastigmes, 19 parts of the fruit of summer cypress.
Preparation process is consistent with embodiment 3.
Embodiment 6 clinical testings
The clinical observation of medicine treatment onychomycosis of the present invention
1, case selection: the patient who selects to be diagnosed as according to symptom and examination in hospital onychomycosis is the object of observation. Test 1-5The Chinese medicine preparation that group adopts respectively embodiment of the present invention 1-5 medicine to make is treated. Contrast 1 group and adopt Da Kening, contrast2 groups adopt bright first to treat, contrast 3 groups adopt medicines except not comprising tinosporae, all the other formulas and preparation process andEmbodiment 5 is consistent, contrasts 4 groups of medicines that adopt except only containing tinosporae, and preparation process is consistent with embodiment 5. Test groupTotally 250 examples, every group of 50 examples, contrast 1 group of totally 50 example, contrast 2 groups of totally 50 examples, contrast 3 groups of totally 50 examples, contrast 4Group totally 50 examples. The course of disease, the degrees of symptoms etc. of each group case, comprehensive average rear there was no significant difference, has between each groupComparativity.
2, methods for the treatment of: test 1-5 group is cleaned affected part every night with contrasting 3-4 group, and ointment is spread upon to disease first table equablyFace applies with medicine, seals with " adhesive bandage ", keep 10 hours, and within 7 days, be a course for the treatment of, use continuously two treatments of the present inventionJourney. The administrated method of control group 1 and control group 2 is according to the description of product used.
3, diagnostic criteria:
Cure: bear new nail, negative fungal examination.
Effective: onychomycosis part reduces, negative fungal examination.
Invalid: symptom part alleviates, the fungus microscope examination positive.
4, treatment results is as shown in table 1
Table 1
As can be seen from the above table, the cure rate of test 1-5 group is more than 86%, and the cure rate that contrasts 1 group is 36%, rightBe 40% according to the cure rates of 2 groups. The cure rate of test 1-5 group has conspicuousness effect compared with two control groups. Test 1-5 groupTotal effective rate be more than 96%, the total effective rate that contrasts 1 group is 76%, the total effective rate that contrasts 2 groups is 78%. ExaminationThe total effective rate of testing 1-5 group compared with two control groups have a conspicuousness effect. Test 5 groups with the comparison that contrasts 3-4 group, canKnow, drug effect of the present invention is to work under the acting in conjunction of each component. Healing case in test 1-5 group, after 1 yearPay a return visit all without recurrence.
Model case:
1, rely certain, man, 57 years old, ill 8 years of right crus of diaphragm halluces first, two big toe, middle toe and five toenails of left foot, through inspectionLook into and be diagnosed as onychomycosis, pulled out first in hospital, got well recurrence again in 2 years, used a lot of externally applied drugs, all do not feel any better, oftenRepeatedly; Through using the embodiment of the present invention 5 medicines, through the treatment of 10 days, existing toenail full recovery health, gloss asJust.
2, grandson, man, 68 years old, left foot halluces, two big toes, unknown toe, right crus of diaphragm middle toe, hand thumb, forefinger are suffered fromSick 5 years, seen a lot of hospitals, ate medicine, also medicine is crossed in external application very much, treatment a period of time several, drug withdrawal rear all bad again,Never thoroughly cured, used the embodiment of the present invention 5 medicines, through medication on time in 7 days, nail full recovery health.
3,, female, 43 years old, right crus of diaphragm halluces, two big toes, ill 3 years of left foot middle toe, has seen a lot of hospitals, eatsCross medicine, also medicine is crossed in external application very much, never thoroughly cures, and uses the embodiment of the present invention 4 medicines, through medication on time in 7 days,Nail full recovery health.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned example embodiment, and do not carrying on the backIn the situation of spirit of the present invention or essential characteristic, can realize the present invention with other concrete form. Therefore, no matter fromWhich point, all should regard embodiment as exemplary, and be nonrestrictive, scope of the present invention is by appended powerProfit requires instead of above-mentioned explanation limits, and is therefore intended to drop on all in the implication that is equal to important document of claim and scopeChange and include in the present invention.
In addition although should be appreciated that this description is described according to embodiment, be not that each embodiment only comprises,A technical scheme independently, this narrating mode of description is only for clarity sake, those skilled in the art should be byDescription is done as a whole, and the technical scheme in each embodiment also can be through appropriately combined, and forming those skilled in the art canWith other embodiments of understanding.
Claims (5)
1. a Chinese medicine preparation for the treatment of onychomycosis, is characterized in that, by forming according to the raw material of weight portion below: tinosporae36-46 part, radix tetrastigme 22-29 part, fruit of summer cypress 15-25 part.
2. the Chinese medicine preparation for the treatment of onychomycosis according to claim 1, is characterized in that, by below according to weight portionRaw material composition: tinosporae 39-43 part, radix tetrastigme 25-28 part, fruit of summer cypress 18-22 part.
3. the Chinese medicine preparation for the treatment of onychomycosis according to claim 2, is characterized in that, by below according to weight portionRaw material composition: 42 parts of tinosporaes, 27 parts of radix tetrastigmes, 19 parts of the fruit of summer cypress.
4. a preparation method for the Chinese medicine preparation of the treatment onychomycosis as described in as arbitrary in claim 1-3, is characterized in that,Formed by following steps:
1) after tinosporae cleaning, insert defibrination pulverizer and pulverize, add the water of 4-5 times of quality of tinosporae quality to mixSqueeze into pot for solvent extraction with pump afterwards; In pot for solvent extraction, add cellulase, obtain tinosporae leaching liquor; Wherein adding of its cellulaseAmount is 0.6-0.7U/g, 55 DEG C of extraction temperatures, and extraction time is 1.1-1.2h; By tinosporae leaching liquor by decompression distillationMode concentrated, be concentrated into the 15-18% of original volume, make tinosporae concentrate; Tinosporae concentrate is sprayed dry,Obtain tinosporae powder;
2) radix tetrastigme, the fruit of summer cypress are crushed to 80-100 order after cleaning, then add the two weight 7-8 absolute ethyl alcohol doubly,Under 60-65 DEG C, air-proof condition, stir and soak 5-6h, then decoct 10-15min, then add the two weight 7-8 doublyAbsolute ethyl alcohol continue to decoct 0.5-0.7h, after filtration the first filtrate, to adding doubly anhydrous of the two weight 3-4 in filter residueEthanol decocts 20-30min, filters to obtain the second filtrate, merges twice filtrate, concentrated by the mode of decompression distillation, concentratedTemperature is 47 DEG C, is concentrated into the 30-40% of original volume, then adds tinosporae powder, continues to be condensed into medicinal extract and obtains treatment ashThe Chinese medicine preparation of nail.
5. the application in the medicine of preparation treatment onychomycosis according to the arbitrary described Chinese medicine preparation of claim 1-3.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111388529A (en) * | 2020-03-23 | 2020-07-10 | 云南西草资源开发有限公司 | Pharmaceutical composition for treating onychomycosis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103007125A (en) * | 2013-01-21 | 2013-04-03 | 任磊 | Traditional Chinese medicine decoction for treating onychomycosis as well as tinea manus and pedis |
| CN103705811A (en) * | 2014-01-10 | 2014-04-09 | 山东盛宏医药科技有限公司 | External traditional Chinese medicine preparation for treating tinea unguium and preparation method thereof |
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2016
- 2016-01-05 CN CN201610009452.5A patent/CN105596577A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103007125A (en) * | 2013-01-21 | 2013-04-03 | 任磊 | Traditional Chinese medicine decoction for treating onychomycosis as well as tinea manus and pedis |
| CN103705811A (en) * | 2014-01-10 | 2014-04-09 | 山东盛宏医药科技有限公司 | External traditional Chinese medicine preparation for treating tinea unguium and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111388529A (en) * | 2020-03-23 | 2020-07-10 | 云南西草资源开发有限公司 | Pharmaceutical composition for treating onychomycosis and preparation method thereof |
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Application publication date: 20160525 |