CN101361857B - Nasal cavity surface preparation - Google Patents
Nasal cavity surface preparation Download PDFInfo
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- CN101361857B CN101361857B CN2008101985293A CN200810198529A CN101361857B CN 101361857 B CN101361857 B CN 101361857B CN 2008101985293 A CN2008101985293 A CN 2008101985293A CN 200810198529 A CN200810198529 A CN 200810198529A CN 101361857 B CN101361857 B CN 101361857B
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Abstract
The invention discloses a preparation for the surface of a nasal cavity, which comprises pimiento and medical ingredients commonly used for pharmacy; by being added with medical materials including fructus xanthii, flos magnolia and liquorice, the preparation can be prepared into a rhinitis curing compound preparation which has a good synergetic effect and acts directly on the nasal mucosa, thus being safe and effective, having fast effects, and be capable of comprehensively controlling and thoroughly improving the symptom of allergic rhinitis.
Description
Technical field
The invention belongs to medical technical field, relate to a kind of drug compound preparation, be specifically related to a kind of na-sal cavity surfaces preparation of treatment of allergic rhinitis.
Background technology
The perennial allergic rhinitis is commonly referred to allergic rhinitis (Allergicalrhnitis), is a kind of nasal mucosa anaphylaxis, it is characterized by paroxysmal, repeatedly Rhinorrhea, sneeze, nasal obstruction and rhinocnesmus takes place.The nasal membrane edema is typical Lycoperdon polymorphum Vitt or dusty blue, has temporary or permanent taste and smell to go down, and involves pharyngotympanic tube like edema, then has ear to swell, even auditory dysesthesia, and nasal secretion is thin, water sample, include eosinophil.Patient often causes the nasal membrane damage owing to showing effect repeatedly; Cause secondary infection; Pathological changes is increased the weight of, and mucosa is the graininess polymorphonuclear cell to be increased, and has cell to invade profit and proliferation of fibrous tissue under the mucosa; Secretions transfers purulence to and has the blood streak, and the state of an illness further develops and can cause and bring out bronchial asthma.Perennial allergic rhinitis's the cause of disease is because the special sensitivity response of nasal mucosa.Antigen is inhalation (inhalatio), food, antibacterial or physical factor.Inhalation (inhalatio) often is a dust in the air, house moss, the usual analyte that is mostly building, feather etc., and mycete and antibacterial.Report that according to statistics domestic sickness rate is 5～15%.
Generally adopt following therapy for treating allergic rhinitis at present clinically: hyposensitization, i.e. immunotherapy; Non-specific treatment; Antihistamine drug's treatment; Hormone therapy; Antibiotic therapy and operative treatment.The perennial allergic rhinitis, with above-mentioned single drug treatment, therapeutic effect is poor, and the cycle is long, and the side reaction of medicine is big, and treatment cycle often is difficult to continue, even adopt combination therapy, effect also is difficult to certainly.If adopt this traumatic Therapeutic Method of operative treatment, will influence the function of patient's olfactory sensation with the infringement of defence pathogen.
Methods such as the common clinically dialectical employing invigorating the lung and benefiting vital QI of Chinese traditional treatment allergic rhinitis, invigorating the spleen to clear away damp pathogen, a surname's clearing the nasal passage are treated with prescription in healthy energy Chinese medicine and the heat clearing away toxin expelling, and set upright and hold concurrently with eliminating evil, effective controlling symptoms not only, and be difficult for recurring.But Chinese traditional treatment is at present boiled medicine by the side and is taken, and can not directly act on the nasal mucosa affected part, and fried Chinese medicine is more loaded down with trivial details, and patient is difficult to adhere to.Also have the hot pepper paste of employing to be equipped with chili wine immersion, Semen daturae etc. and be prepared into hot pepper paste external application acupuncture point with treatment of allergic rhinitis, medicine can not directly act on the nasal mucosa affected part equally, and curative effect is not very stable.
Capsaicin (capsaicin) is applied to the existing at present relevant report of therapeutical effect of allergic rhinitis; There is report proof capsaicin can alleviate watery nasal discharge and sneeze, reduces SP-IR fibre density and quantity, and reach the purpose of treatment allergic rhinitis; But capsaicin directly uses zest bigger; Also be easy to generate side effect, lack at present a kind of safe, effective, effect rapidly, directly act on the nasal cavity preparation that nasal mucosa is controlled the rhinitis symptom comprehensively, especially lower-cost Chinese medicine preparation.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art; A kind of na-sal cavity surfaces preparation of treatment of allergic rhinitis is provided; To perennial allergic rhinitis's pathogenic factor; The characteristics of mucositis shape symptom and the various kinds of drug performance of outbreak, curative effect are screened and are studied repeatedly, provide a kind of safe, effective, effect rapidly, directly act on the na-sal cavity surfaces preparation that nasal mucosa is controlled the rhinitis symptom comprehensively.
The object of the invention is achieved through following technical scheme:
A kind of na-sal cavity surfaces preparation is provided, and said preparation comprises Fructus Capsici and pharmaceutically acceptable excipient substance.
The weight ratio of said Fructus Capsici and pharmaceutically acceptable excipient substance is preferably 6: 40～and 60.
Said pharmaceutically general or acceptable drug adjuvant comprises vegetable oil, conventional spray composition or other conventional excipient substances that uses.
Said na-sal cavity surfaces preparation can be to comprise Fructus Capsici, Chinese crude drug Fructus Xanthii and pharmaceutically general excipient substance.
Said na-sal cavity surfaces preparation can be to comprise Fructus Capsici, Fructus Xanthii, Flos Magnoliae flower and pharmaceutically general excipient substance.
Said na-sal cavity surfaces preparation comprises Fructus Capsici, Fructus Xanthii, Flos Magnoliae flower, Radix Glycyrrhizae and pharmaceutically acceptable excipient substance.
The weight ratio of said Fructus Capsici, Fructus Xanthii, Flos Magnoliae flower, Radix Glycyrrhizae and pharmaceutically acceptable excipient substance is preferably 6: 2: 1: 2: 40.The Chinese crude drug that said Fructus Xanthii, Flos Magnoliae flower, Radix Glycyrrhizae can adopt the Chinese crude drug shop to buy does not need special handlings such as pulverizing.
The present invention provides the method for preparing of said na-sal cavity surfaces preparation simultaneously, it is characterized in that may further comprise the steps:
(1) mixture of oil immersion system Fructus Capsici or Fructus Capsici and Chinese crude drug is after 3～5 days, and the big fire heated and boiled transfers to low baking temperature and boils about 3 minutes, closes fire, and oil immersion promptly gets the medical material mixture after 3～5 days; Oil can adopt vegetable oil, and the weight ratio of Fructus Capsici, Fructus Xanthii, Flos Magnoliae flower, Radix Glycyrrhizae and vegetable oil is 6: 2: 1: 2: 40.
(2) the medical material mixture that adopts conventional method that (1) is made filters and obtains liquid, is primary raw material with liquid, need add pharmaceutically general other drug adjuvant according to dosage form, is prepared into ointment, cream, nasal spray or nasal drop according to conventional method.
Said na-sal cavity surfaces preparation can be applicable to prepare the medicine of allergic rhinitis.
The foundation of each drug matching shows as among the present invention:
1, Fructus Capsici mainly contains capsaicin, and the differential stimulus mucosa does not have marrow C fiber, discharges neuropeptide, is the important drugs that stimulates and block the P material, in research nerve inflammation, the reactive Pathophysiology of nasal height, treating allergic rhinitis, plays a significant role.
2, Chinese crude drug Fructus Xanthii, Flos Magnoliae flower, nose section guiding drug. be used for nasosinusitis headache, headche due to wind-cold.Gentle the dredging of these article reaches, the acrid in the mouth wind that looses, bitter dampness is turbid, understand things pain-stopping, with control nasosinusitis headache, anosmia, the time flow turbid tears.
3, the Chinese crude drug Radix Glycyrrhizae can be alleviated the Fructus Capsici stimulation and suppress the nasal mucosa allergy, suppresses the generation of Prostaglandins and Leukotrienes, alleviates allergic irritation.Alleviate symptoms such as mucosa swelling, nasal obstruction; Strengthen the vasoconstrictive effect of youngster Cai phenol amine, contrafluxion is alleviated: suppress to cause the generation of scorching active substance prostate and leukotriene, reduce the generation of tears liquid.
Allergic rhinitis often treatment cycle is long; Although adopt the nasal cavity topical, also can adopt antihistaminic, hormone all can bring the property side reaction of various medicines source because of the big generation general action of drug absorption because of life-time service; Therefore increase local vascular among the present invention and shrink medicine; Can reduce the absorbtivity of medicine, improve the concentration of topical remedy, increase drug effect; Simultaneously can improve nasal mucosa swelling, alleviate nasal obstruction, improve the permeability and the nasal mucosa inflammation of nasal cavity.
Through the applicant's lot of experiments, filter out the reasonable assembly of said medicine, but the synergism essence that therefore produces is improved the symptom of allergic rhinitis, the rhinitis patient who makes some existing medicines be difficult to cure is improved at all or is cured.
The specific embodiment
Come further explain the present invention below in conjunction with specific embodiment.
The preparation of embodiment 1 na-sal cavity surfaces preparation
Selecting the scarlet dried green pepper of Fructus Capsici fruit is raw material, removes the base of a fruit and seed, washes to drain;
It in vegetable oil, chilli weight ratio 40: 6 ratio preparing raw materials; Behind the oil immersion system Fructus Capsici 3～5 days, the big fire heated and boiled transfers to low baking temperature and boils about 3 minutes, and 3～5 days after-filtration of infuse obtain liquid and promptly get again.
The preparation of embodiment 2 na-sal cavity surfaces preparations
Selecting the scarlet dried green pepper of Fructus Capsici fruit is raw material, removes the base of a fruit and seed, washes to drain;
In vegetable oil, chilli, Fructus Xanthii weight ratio is that 40: 6: 2 ratio is ready to various raw materials; Oil immersion system Fructus Capsici and Fructus Xanthii are after 3～5 days, and the big fire heated and boiled transfers to low baking temperature and boils about 3 minutes, and 3～5 days after-filtration of infuse obtain liquid again, get liquid and add conventional nasal spray preparation of compositions and obtain spray.
The preparation of embodiment 3 na-sal cavity surfaces preparations
Selecting the scarlet dried green pepper of Fructus Capsici fruit is raw material, removes the base of a fruit and seed, washes to drain;
In vegetable oil, chilli, Fructus Xanthii, Flos Magnoliae flower weight ratio is 40: 6: 2: 1 ratio is ready to various raw materials; After oil immersion system Fructus Capsici, Fructus Xanthii and Flos Magnoliae were spent 3～5 days, the big fire heated and boiled transferred to low baking temperature and boils about 3 minutes, and 3～5 days after-filtration of infuse obtain liquid again, got liquid and added that general adjuvant prepares unguentum on the medicine.
The preparation of embodiment 4 na-sal cavity surfaces preparations
Selecting the scarlet dried green pepper of Fructus Capsici fruit is raw material, removes the base of a fruit and seed, washes to drain;
In vegetable oil, chilli, Fructus Xanthii, Flos Magnoliae flower, Radix Glycyrrhizae weight ratio is 40: 6: 2: 1: 2 ratio is ready to various raw materials; Oil immersion system Fructus Capsici, Fructus Xanthii, Flos Magnoliae flower and Radix Glycyrrhizae are after 3～5 days, and the big fire heated and boiled transfers to low baking temperature and boils about 3 minutes, and 3～5 days after-filtration of infuse obtain liquid again, get liquid and add that general adjuvant can prepare unguentum according to conventional method on the medicine.
The clinical research that embodiment 5 uses na-sal cavity surfaces preparation for treating allergic rhinitis
1, experimental technique: take control experiment method at random
The hospital outpatient allergic rhinitis patients is totally 200 examples, all meets perennial allergic rhinitis's diagnostic criteria that Chinese Medical Association works out.Adopt randomized to be divided into 2 groups, 100 examples are organized in treatment, matched group 100 examples.Use the present invention to implement the treatment group, male 51 examples, women 49 examples, 14～57 years old age, average 29.7 ± 10.6 years old, the course of disease 2～6 years, average 3.5 ± 1.8 years; Matched group 60 examples; Man's 48 examples, women 52 examples, 15～54 years old 28.6 ± 12.3 years old age; The course of disease 2～5 years; Average 3.2 ± 1.6 years, all patients all had sings and symptomses such as in various degree sneeze, watery nasal discharge, nasal obstruction, concha nasalis enlargement, and the perennial allergic rhinitis that the classification score standard of symptom, sign is worked out according to Chinese Medical Association diagnoses criterion of therapeutical effect to carry out.There are no significant (P>0.05) for patient's differences such as sex, age, the course of disease between each group.
2, diagnostic criteria
Comprise standard: allergic rhinitis patients does not have smoking or stops smoking more than 2 years.
Exclusion standard: gestation, apositia, polyphagia, unstable angina pectoris, arrhythmia, the thyroid pathological changes, symptomatic hepatopathy, gallbladder pathological changes and any serious pathological changes that do not have treatment, insulinize, oral hormone treatment.
3, administrated method and dosage
Therapeutic Method: the two groups of course of treatment in equal 6 weeks.
The treatment group:
The cotton sheet of (1) 1% tetracaine 0.3ml deposited concha nasalis 10 minutes, same operation totally 2 times;
(2) preparation of the present invention: can select embodiment 1,2,3 or 4 said preparations for use, perhaps according to the preparation of the present invention's preparation, the cotton sheet of 0.1～0.2ml deposited concha nasalis 15 minutes, same operation totally 2 times.
(1) and (2) said operation 1 time weekly.
(3) conventional treating allergic rhinitis.
Matched group:
The cotton sheet of (1) 1% tetracaine 0.3ml deposited concha nasalis 10 minutes, same operation totally 2 times;
(2) conventional treating allergic rhinitis.
Conventional treating allergic rhinitis:
Gently: ketotifen every day 1 time, each 1mg
In: ketotifen every day 1 time, each 1mg adds beclometasone conventional therapy dosage every day 1 time
Heavy: ketotifen every day 1 time, each 1mg adds beclometasone conventional therapy dosage every day 2 times
4, observation project and index
(1), the variation of observation item clinical symptoms and sign;
(2), criterion of therapeutical effect
Allergic rhinitis: the perennial allergic rhinitis that the classification score standard of symptom, sign is worked out according to Chinese Medical Association diagnoses criterion of therapeutical effect to carry out, and the gained integration calculates curative effect by following formula: integration * 100% before integration decline index=(integration before treating-treatment back integration) treated.Produce effects: integration decline index>=66%; Effectively: integration decline index>=26%; Invalid: integration decline index<25%; Produce effects and effective percentage rate are designated as total effective rate.
(3), therapeutic outcome
Allergic rhinitis: two groups of curative effect comparative observations are treated after 30 days treatment group produce effects 75 examples, effective 24 examples, invalid 1 example, total effective rate 98.3%.Matched group produce effects 46 examples, effective 46 examples, invalid 8 examples, total effective rate 86.7%.Two groups of total effective rate difference has significance (P < 0.01).The result sees shown in the table 1.
Two groups of curative effects of table 1 allergic rhinitis relatively
The untoward reaction of twinge appears in the treatment group, but can stand.
Claims (1)
1. the na-sal cavity surfaces preparation of a treatment of allergic rhinitis is characterized in that said preparation is that to select the scarlet dried green pepper of Fructus Capsici fruit be raw material, removes the base of a fruit and seed, washes to drain; In vegetable oil, chilli, Fructus Xanthii, Flos Magnoliae flower, Radix Glycyrrhizae weight ratio is 40: 6: 2: 1: 2 ratio is ready to various raw materials; Oil immersion system Fructus Capsici, Fructus Xanthii, Flos Magnoliae flower and Radix Glycyrrhizae are after 3～5 days, and the big fire heated and boiled transfers to low baking temperature and boils about 3 minutes, and 3～5 days after-filtration of infuse obtain liquid again, get liquid and add the unguentum that general adjuvant prepares according to conventional method on the medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101985293A CN101361857B (en) | 2008-09-16 | 2008-09-16 | Nasal cavity surface preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101985293A CN101361857B (en) | 2008-09-16 | 2008-09-16 | Nasal cavity surface preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101361857A CN101361857A (en) | 2009-02-11 |
| CN101361857B true CN101361857B (en) | 2012-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2008101985293A Expired - Fee Related CN101361857B (en) | 2008-09-16 | 2008-09-16 | Nasal cavity surface preparation |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810726B (en) * | 2010-03-30 | 2011-12-21 | 广东药学院 | Chinese medicinal preparation for treating chronic rhinosinusitis and preparation method thereof |
| CN108186859A (en) * | 2018-03-13 | 2018-06-22 | 贵州健安德科技有限公司 | Treat Chinese medicine preparation of rhinitis and preparation method thereof |
| CN112472669A (en) * | 2020-12-18 | 2021-03-12 | 曲阜师范大学 | Nasal spray based on red pepper extract and heparin for preventing influenza and preparation method thereof |
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