CN105596488A - Pharmaceutical composition for treating psoriasis and preparation method thereof - Google Patents

Pharmaceutical composition for treating psoriasis and preparation method thereof Download PDF

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Publication number
CN105596488A
CN105596488A CN201610033121.5A CN201610033121A CN105596488A CN 105596488 A CN105596488 A CN 105596488A CN 201610033121 A CN201610033121 A CN 201610033121A CN 105596488 A CN105596488 A CN 105596488A
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composition
prepared
antipsoriatics
blood
water
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何东良
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Guangxi Fuxinyi Biological Technology Co Ltd
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Guangxi Fuxinyi Biological Technology Co Ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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Abstract

The invention relates to a pharmaceutical composition for treating psoriasis and a preparation method thereof. The pharmaceutical composition is prepared from mallotus apelta, adina pilulifera, cortex dictamni, radix arnebiae seu lithospermi, acetic acid, vaseline and indirubin. The pharmaceutical composition has the functions of clearing heat and expelling dampness and cooling blood and eliminating toxins, and has excellent treatment effect on blood-heat and blood-dryness type psoriasis.

Description

A kind of antipsoriatics compositions and preparation method thereof
Technical field
The present invention relates to drug world, be specifically related to one and be used for the treatment of psoriasic pharmaceutical composition and preparation side thereofMethod.
Background technology
Psoriasis is commonly called as " psoriasis ", is inflammatory, recurrent skin disease with erythema, papule, silvery white scales of skin that peel off master, seesPerson between twenty and fifty, winter-spring season easily recurs or increases the weight of, and takes a turn for the better summer or disappears and repeatedly shown effect by psoriasis, the definite cause of disease of protracted course of diseaseNot yet clear, order does not also have a kind of primal therapy can control its recurrence. So, therapeutic scheme should advocate " green non-poisonous, reduce multipleSend out " principle.
The traditional Chinese medical science thinks, it is scorching that psoriatic etiology and pathogenesis mostly is plain body skin, blood-head, dry, the cloudy consumption of blood and fall ill for a long time, and blood-headThe interpretation of the cause, onset and process of an illness run through onset of psoriasis process all the time, treatment often taking clearing heat and detoxicating, cooling and activating blood, nourshing Yin and drynsessmoistening prescription as method. According to silverThe performance of considering disease three different times to be worth doing can be divided into three cards, i.e. blood-heat syndrome, syndrome of blood stasis, the dry card of blood.
1, blood-heat syndrome
Be more common in onset, the shorter patient of the course of disease. Fash mostly is drop shape, and look scarlet, and newly rash constantly occurs, old rash constantly expandsGreatly, inflammatory infiltration is obvious, the scales of skin that peel off from less to more, itch degree varies, tongue is red, tongue is yellow, arteries and veins string. Therapy: clearing away heat,cooling blood and removing toxin.
2, syndrome of blood stasis
Be more common in resting stage, the patient that the course of disease is grown. Fash is patch shape, and look dark red, and the scales of skin that peel off is thicker, is silvery white in color, and seldom hasNew rash occurs, obstinate refractory, and some patients were itch is obvious, purplish tongue, stringy and hesitant pulse. Therapy: promoting blood circulation and removing blood stasis.
3, the dry card of blood
Be more common in paracmasis, the patient that the course of disease is more of a specified duration. Erythema, infiltration are disappeared gradually, and the scales of skin that peel off reduces, and itch alleviates or be not obvious,Tongue is red, and tongue is few, small and wiry pulse. Therapy: enriching the blood to restore normal menstruation, supplementing qi and nourishing yin.
Summary of the invention
The object of this invention is to provide a kind of antipsoriatics compositions;
Another object of the present invention is to provide a kind of preparation method of antipsoriatics compositions.
The object of the invention is to realize by following technical scheme:
Antipsoriatics compositions of the present invention is to be prepared from by the medicine material that comprises following weight portion:
Whitebackleaf Mallotus Root 5-15 part, water body flower 10-20 part, root bark of shaggy-fruited dittany 5-15 part, Asian puccoon 5-15 part.
Its active component is prepared from by the following method:
Solubilizer extracts 2-3 time, and each solubilization dosage is equivalent to 6-12 times of medicine gross weight, and each extraction time is that 1-3 is littleTime, merge extract, filter, the clear cream that when filtrate is concentrated into 70-80 DEG C, relative density is 1.15-1.20, obtains active one-tenthPoint; Described solvent is the ethanol of water or 40-80%.
Preferably, described antipsoriatics compositions, is to be prepared by the medicine material that comprises following weight portionForm:
Composition 1: Whitebackleaf Mallotus Root 5-15 part, water body flower 10-20 part, root bark of shaggy-fruited dittany 5-15 part, Asian puccoon 5-15 part;
Composition 2: acetic acid 5-8 part, indigo red 3-5 part, vaseline 50-80 part.
Its active component is prepared from by the following method:
(1) the whole medicine solubilizers in composition 1 are extracted 2-3 time, each solubilization dosage is equivalent to the 6-of medicine gross weight12 times, each extraction time is 1-3 hour, merges extract, filters, and when filtrate is concentrated into 70-80 DEG C, relative density isThe clear cream of 1.15-1.20, described solvent is the ethanol of water or 40-80%; ;
(2) pulverizing of the indigo red in composition 2 mistake 80 mesh sieves afterwards, and the clear cream of step (1) gained mix, and obtain mixture;
(3) by the vaseline heat fused in composition 2, be cooled to 40-70 DEG C, add acetic acid and step (2) in composition 2The mixture of gained, to obtain final product.
Below the crude drug source of Chinese medicine of the present invention:
Whitebackleaf Mallotus Root is Euphorbiaceae Mallotus plant Whitebackleaf Mallotus Root Mallotusapelta(Lour.) Muell.-Arg. with root andLeaf is used as medicine. Micro-hardship, puckery, flat. Root: soft liver is invigorated blood circulation, invigorating the spleen for eliminating dampness, convergence is solid de-. For chronic hepatitis, hepatosplenomegaly, uterus is de-Hang down, prolapse of the anus, leukorrhea, cyesedema. Leaf: anti-inflammation hemostasia. Tympanitis is controlled in external application, furuncle, traumatic injury, traumatism and bleeding.
Water body flower is branches and leaves or the flowers and fruits of madder wort water body flower. Can adopt at any time using fresh herb or dry use. Hardship, flat. ClearlyHot dampness removing, the stasis of blood that disappears analgesic therapy, hemostasia and promoting granulation. Control dysentery, enteritis, damp and hot edema, carbuncle sore tumefacting virus, eczema, rotten pin, unhealing ulcer, woundHinder hemorrhage.
The root bark of shaggy-fruited dittany is the dry root skin of rutaceae shaggy-fruited dittany DictamnusdasycarpusTurcz.. Hardship, cold.Return spleen, stomach, urinary bladder channel. Heat-clearing and damp-drying drug, the removing toxic substances of dispeling the wind. For damp and hot sore, yellow water is dripping, eczema, rubella, mange sore leprosy, windDamp-heat arthralgia, jaundice urine is red.
Asian puccoon is comfrey lithospermum euchromum Royle Arnebiaeuchroma(Royle) Johnst., Asian puccoonOr arnebia guttata Bunge ArnebiaguttataBunge LithospermumerythrorhizonSieb.etZucc.Dry root. Sweet, salty, cold. The thoughts of returning home, Liver Channel. Cool blood, invigorates blood circulation, removing toxic substances promoting eruption. Contain for blood-head poison, macula purple is black, measles without adequate eruption,Sore, eczema, scald.
Antipsoriatics compositions of the present invention, can coordinate with pharmaceutically acceptable carrier, systemBecome various common dosage forms, as liniment, lotion, tincture, gel, (soft) paste, emplastrum etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: distilled water, ethanol etc.
Cosolvent: the polyalcohols such as glycerine, propane diols, sorbierite.
Anticorrisive agent: benzoic acid, Sodium Benzoate, propionic acid, parabens, ethyl-para-hydroxybenzoate etc.
Oleaginous base: vaseline, liquid paraffin, lanolin, beeswax, animal oil, vegetable oil, glycerin monostearate,18 alcohol etc. and composition thereof,
Water-soluble base: glycerine, sodium alginate, carbopol resin, starch gelatin, methylcellulose, sodium carboxymethylcellulose,Polyethylene glycol, polyvinyl alcohol.
Transdermal enhancer: cutin moisturizing diuretin, pyrrolones derivative, linoleic acid, laruyl alcohol, tween, dodecyl front threeBase ammonium bromide, dodecyl sodium sulfate, lauryl sodium sulfate, menthol, Laurocapram (azone) etc.
For example, it can be prepared as various common formulations by one of following method:
Method 1: liniment
Get active component, add liniment to commonly use auxiliary material, production method is prepared into liniment of the present invention routinely.
The conventional auxiliary material of above-mentioned liniment comprises one of diluent, anticorrisive agent, cosolvent, transdermal enhancer or whole.
Method 2: paste
Get active component, add paste to commonly use auxiliary material, production method is prepared into paste of the present invention routinely.
The conventional accessory package of above-mentioned paste is drawn together one of oleaginous base, water-soluble base, anticorrisive agent, transdermal enhancer or whole.
Method 3: emplastrum
Get active component, make with matrix and base material that emplastrum is conventional.
Above-mentioned emplastrum acceptable substrate comprises cotton, nonwoven, paper, plastic sheeting, aluminium foil, polyethylene composite film, hardOne of gauze; Conventional matrix comprises one of oleaginous base, water-soluble base, anticorrisive agent, transdermal enhancer or whole.
Method 4: gel
Get active component, after concentrating, mix with conventional gel-type vehicle, production method is prepared into gel of the present invention routinely.
The conventional matrix of above-mentioned gel comprises the husky mother in carbomer, gelatin, bassora gum, cellulose family and pool Lip river etc., also can add shortOne of agent thoroughly, cosolvent, diluent or whole.
Method 5: pulvis
Get whole medicinal materials and be broken into meal, cross 80-100 mesh sieve, obtain pulvis of the present invention.
The applicant on the basis of research tradition tcm syndrome differentiation and treatment with reference to modern pharmacological research achievement, through examination for many yearsTest, multiple formulations is screened, found the fine antipsoriatics compositions of energy that cooperatively interacts. The present invention's formula closesReason innovation, root bark of shaggy-fruited dittany heat-clearing and damp-drying drug; Asian puccoon removing pattogenic heat from the blood and toxic material from the body; The water body flower heat-clearing silt that disappears; Whitebackleaf Mallotus Root anti-inflammatory. All medicines share above, toolThere is the merit of heat-clearing and damp-drying drug, removing pattogenic heat from the blood and toxic material from the body, splendid to blood-head blood-dryness type psoriasis curative effect.
In addition, in preferred version, added indigo red, indigo red is the active ingredient of extracting from Chinese medicine indigo naturalis. Use indigoRubine treatment chronic myelocytic leukemia has good result, and the pathology that psoriasis is given prominence to becomes, and is that epidermal cell proliferation is vigorous,Have similar part with tumour, indigo red also can be treated psoriasis clinically; Acetic acid has biocidal efficacies, can also promote the saturating of medicineSkin absorbs; And vaseline has splendid lock water effect, remarkable for skin moisture-keeping effect, psoriatic uses can be from oneDetermine in degree to alleviate dry symptom, antipruritic and reduce the booster action having on the coming off of scurf in psoriasis, also can be used as workProperty composition is prepared into the matrix of preparation.
Technical solution of the present invention meets the mechanism of tcm treatment according to syndrome differentiation, bases oneself upon the origin of disease, reasonable recipe science.
A kind of antipsoriatics compositions provided by the invention has the following advantages:
1, composition provided by the invention is safe and effective, has the merit of heat-clearing and damp-drying drug, removing pattogenic heat from the blood and toxic material from the body, to blood-head blood-dryness type psoriasisCurative effect is splendid; 2, preferred version adds indigo red, acetic acid and vaseline, and the fresh treatment of ox-hide and alleviation have all been played greatlyEffect: indigo red epidermal cell proliferation; Acetic acid sterilization; Vaseline is antipruritic, minimizing scurf comes off. Coordinate with above-mentioned Chinese medicine, especiallyStrengthen the psoriasic curative effect for the treatment of; 3, the embodiment of the present invention 2 and embodiment 5 treat psoriasic total effective rate and are respectively90.7%, 96.3%,, medicine composite for curing psoriasis of the present invention is evident in efficacy, and its effect is combined by composition 1, composition 1+Thing 2 increases progressively; 4, drug regimen composition formula of the present invention is rationally innovated, and production cost is low, technique is simple.
Detailed description of the invention
Further illustrate the present invention below by embodiment. It should be understood that embodiments of the invention are for explanationThe present invention instead of limitation of the present invention. The simple modifications that essence according to the present invention is carried out the present invention all belongs to the present inventionClaimed scope. Except as otherwise noted, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v represents solutionVolume ratio.
Embodiment 1 liniment
Take Whitebackleaf Mallotus Root 5kg, water body flower 10kg, root bark of shaggy-fruited dittany 5kg, Asian puccoon 5kg. With alcohol heating reflux extraction 2 times, each ethanolConcentration is respectively 80%, 40%, and each ethanol consumption is respectively 10 times, 8 times of medicinal material total amount, and extraction time is respectively 3 hours, 1Hour, merge extract, filter, filtrate recycling ethanol, adds 0.1% Sodium Benzoate, 0.05% methyl hydroxybenzoate, mixes,Packing, obtains liniment of the present invention.
Embodiment 2 paste
Take Whitebackleaf Mallotus Root 15kg, water body flower 20kg, root bark of shaggy-fruited dittany 15kg, Asian puccoon 15kg. Extracting in water 3 times, three amount of water respectivelyFor 12 times, 8 times, 6 times of medicinal material gross weight, extraction time is respectively 3 hours, 2 hours, 1 hour, merges extract, filters filterThe clear cream that when liquid is concentrated into 80 DEG C, relative density is 1.20, for subsequent use.
Take stearic acid 15g, vaseline 100g, lanolin 80g, glyceryl stearate 35g, hexadecanol 80g, is heated to85 DEG C, stir evenly, as oil phase, for subsequent use; Separately get glycerine 130g, ethyl-para-hydroxybenzoate 2g, lauryl sodium sulfate 20g, monthOsmanthus Azone 25g, adds above-mentioned thick paste and volatile oil, and water regulates and makes oil, water two-phase 1000g altogether, as water, is heated to 90DEG C, after all dissolving, constant temperature to 85 DEG C, stirs evenly; Oil phase is slowly added to water, put in refiner and stir, cooling, solidify,Packing, obtains paste of the present invention.
Embodiment 3 paste
Composition 1: Whitebackleaf Mallotus Root 5kg, water body flower 10kg, root bark of shaggy-fruited dittany 5kg, Asian puccoon 5kg;
Composition 2: acetic acid 5kg, indigo red 3kg, vaseline 50kg.
Described antipsoriatics compositions, its paste is prepared from by the following method:
(1) the whole medicines in composition 1 are added to 80% ethonal extraction 2 times, each solubilization dosage is equivalent to medicine gross weight10 times, 8 times, each extraction time is 2 hours, merges extract, filters, when filtrate is concentrated into 70 DEG C, relative density is 1.15Clear cream;
(2) pulverizing of the indigo red in composition 2 mistake 80 mesh sieves afterwards, and the clear cream of step (1) gained mix, and obtain mixture;
(3) by the vaseline heat fused in composition 2, be cooled to 40 DEG C, add acetic acid and step (2) institute in composition 2The mixture obtaining, to obtain final product.
Embodiment 4 gels
Take Whitebackleaf Mallotus Root 10kg, water body flower 15kg, root bark of shaggy-fruited dittany 10kg, Asian puccoon 10kg. Extracting in water 2 times, twice amount of water respectivelyFor 10 times, 8 times of medicinal material gross weight, merge extract, filter, the clear cream that when filtrate is concentrated into 70 DEG C, relative density is 1.15,Mix, obtain active component for subsequent use.
Carbomer is spread in appropriate distilled water, fully swelling, add propane diols, Laurocapram to grind and make to soak,Add triethanolamine and grind to form clear gel matrix, water-bath to 70 DEG C. Get after propane diols, the dissolving of Tween-80 Hybrid Heating, by above-mentionedActive component joins in matrix, and slow quickening stirs, and adding distil water, continues to stir, and obtains the agent of yellowish-brown clear gel.
Embodiment 5 paste
Composition 1: Whitebackleaf Mallotus Root 15kg, water body flower 20kg, root bark of shaggy-fruited dittany 15kg, Asian puccoon 15kg;
Composition 2: acetic acid 8kg, indigo red 5kg, vaseline 80kg.
Described antipsoriatics compositions, its paste is prepared from by the following method:
(1) the whole medicines in composition 1 are added to 80% ethonal extraction 2 times, each solubilization dosage is equivalent to medicine gross weight10 times, 8 times, each extraction time is 3 hours, 2 hours, merges extract, filters relative density when filtrate is concentrated into 70 DEG CBe 1.15 clear cream;
(2) pulverizing of the indigo red in composition 2 mistake 80 mesh sieves afterwards, and the clear cream of step (1) gained mix, and obtain mixture;
(3) by the vaseline heat fused in composition 2, be cooled to 40 DEG C, add acetic acid and step (2) institute in composition 2The mixture obtaining, to obtain final product.
Embodiment 6 pulvis
Take Whitebackleaf Mallotus Root 12kg, water body flower 18kg, root bark of shaggy-fruited dittany 8kg, Asian puccoon 10kg. Medicinal material cleans, pulverizes, and crosses 80-100 mesh sieve,Obtain pulvis of the present invention.
Clinical testing is summed up
1 data and method
This group psoriatic 108 examples, male 67 examples, female's 41 examples, 38.9 years old mean age, all cases is divided at random by outpatient service2 groups: I group 54 examples, II group 54 examples, 2 groups of patients at aspect comparing differences such as sex, age, the course of disease and severity extents all without systemMeter is learned meaning (P > 0.05).
2 methods of treatments
I group: give paste application affected part described in the embodiment of the present invention 2, every day 3 times.
II group: give paste application affected part described in the embodiment of the present invention 5, every day 3 times.
2 groups all start observe the curative effect in treatment after at least 1 month.
3 curative effect judging standards
1. clinical cure: the fash > 95% that all disappears or disappear, i.e. PASI scoring decline > 95%;
2. effective: deflorescence 75%～94%;
3. effective: deflorescence 31%～74%, PASI scoring declines 31%～74%;
4. invalid: deflorescence < 30%, PASI scoring decline < 30%.
Treatment results treatment results is in table 1:
Table 1: two groups of medicines are on psoriasic impact
Number of cases Recovery from illness Effective Effectively Invalid Total effective rate (%)
I group 54 6 23 20 5 90.7
II group 54 11 25 16 2 96.3
As shown in Table 1: the embodiment of the present invention 2 and embodiment 5 treat psoriasic total effective rate be respectively 90.7%, 96.3%,, thisInvention medicine composite for curing psoriasis is evident in efficacy, and its effect is increased progressively by composition 1, composition 1+ composition 2.
Although, above use general explanation, detailed description of the invention and test, the present invention has been done to detailed retouchingState, but on basis of the present invention, can make some modifications or improvements it, this is apparent to those skilled in the art. Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the present invention claimedScope.

Claims (5)

1. an antipsoriatics compositions, is characterized in that it is to be prepared by the medicine material that comprises following weight portionForm:
Whitebackleaf Mallotus Root 5-15 part, water body flower 10-20 part, root bark of shaggy-fruited dittany 5-15 part, Asian puccoon 5-15 part.
2. antipsoriatics compositions as claimed in claim 1, the active component that it is characterized in that it be by withBelow method is prepared from: solubilizer extracts 2-3 time, and each solubilization dosage is equivalent to 6-12 times of medicine gross weight, carries at every turnThe time of getting is 1-3 hour, merges extract, filters, and what when filtrate is concentrated into 70-80 DEG C, relative density was 1.15-1.20 is clearCream, obtains active component; Described solvent is the ethanol of water or 40-80%.
3. an antipsoriatics compositions, is characterized in that it is to be prepared by the medicine material that comprises following weight portionForm:
Composition 1: Whitebackleaf Mallotus Root 5-15 part, water body flower 10-20 part, root bark of shaggy-fruited dittany 5-15 part, Asian puccoon 5-15 part;
Composition 2: acetic acid 5-8 part, indigo red 3-5 part, vaseline 50-80 part.
4. antipsoriatics compositions as claimed in claim 3, the active component that it is characterized in that it be by withBelow method is prepared from:
(1) the whole medicine solubilizers in composition 1 are extracted 2-3 time, each solubilization dosage is equivalent to the 6-of medicine gross weight12 times, each extraction time is 1-3 hour, merges extract, filters, and when filtrate is concentrated into 70-80 DEG C, relative density isThe clear cream of 1.15-1.20, described solvent is the ethanol of water or 40-80%;
(2) pulverizing of the indigo red in composition 2 mistake 80 mesh sieves afterwards, and the clear cream of step (1) gained mix, and obtain mixture;
(3) by the vaseline heat fused in composition 2, be cooled to 40-70 DEG C, add acetic acid and step (2) in composition 2The mixture of gained, to obtain final product.
5. an antipsoriatics compositions, the antipsoriatics thing by claim 1-4 described in any oneComposition and pharmaceutically acceptable carrier prepare and form.
CN201610033121.5A 2016-01-19 2016-01-19 Pharmaceutical composition for treating psoriasis and preparation method thereof Pending CN105596488A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107233436A (en) * 2017-06-21 2017-10-10 福建农林大学 One kind effectively treats psoriasic compound Chinese medicinal preparation and preparation method thereof
CN107823396A (en) * 2017-11-17 2018-03-23 广西博白县华春福家庭农场 A kind of Chinese medicine composition for treating corn and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107233436A (en) * 2017-06-21 2017-10-10 福建农林大学 One kind effectively treats psoriasic compound Chinese medicinal preparation and preparation method thereof
CN107823396A (en) * 2017-11-17 2018-03-23 广西博白县华春福家庭农场 A kind of Chinese medicine composition for treating corn and preparation method thereof

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Application publication date: 20160525