CN105055800A - Plant compound gel for treating chloasma and preparation method thereof - Google Patents

Abstract

The invention discloses plant compound gel for treating chloasma and a preparation method thereof. The plant compound gel comprises, by weight, the natural plant components of 15-25 parts of red-rooted salvia roots, 15-25 parts of yerbadetajo herbs, 15-25 parts of poria cocos, 15-25 parts of aloe and 10-25 parts of radix scutellariae. The plant compound gel for treating the chloasma has natural plant active components, and the gel which is prepared according to a provided formula and the preparation method can be used in cooperation with any common medicine for treating the chloasma, is suitable for any skin, free of anaphylactic reaction and toxic and side effects and capable of rapidly permeating into the skin and achieving the purpose of treating the chloasma and has a definite treatment effect; relapsing is not likely to occur, natural plant active essence is integrated, the chloasma can be rapidly faded, the skin color can be improved and the skin functions can be restored.

Description

A kind of plant compound gel for the treatment of chloasma and preparation method thereof

Technical field

The present invention relates to a kind of plant compound gel for the treatment of chloasma and preparation method thereof, belong to medical art.

Background technology

Chloasma belongs to Chinese medicine chloasma, chloasma hepaticum, butterfly spot, cyasma category, and being that dermal melanin increases and a kind of common face that formed is the dermatosis of the pigmented damage capacitive of brown or black pigment, is one of department of dermatologry difficult and complicated illness.Mainly occur in face, based on cheekbone portion, buccal, nose, forehead, chin portion, boundary is clear, smooth surface, and symmetrically property distribution, is mainly in the women of anemia of pregnant woman and irregular menstruation.This is sick in chronic process, and the course of disease is obstinate, has a strong impact on patient attractive in appearance, brings many worries and misery to its spirit and life aspect.Along with people's living standard improves, product chloasma being carried out researching and developing to treatment chloasma is extremely important.

Chloasma pathogeny is main relevant with endocrine, especially relevant with the estrogen level of women, and also with inherited genetic factors, micronutrient levels exception, abnormal liver function etc., modern medicine thinks that the factors such as endocrine disturbance, gestation, ovary and uterus disease are relevant.The traditional Chinese medical science think chloasma and liver spleen kidney three dirty in close relations.Many because of pathogenic fire derived from stagnation of liver-QI, or deficiency of the liver and kindey, or dysfunction of the spleen in transportation, cause qi depression to blood stasis, QI-blood failing to nourish upward is caused by the face.There is the medicine of many treatment chloasma in the market, have for oral administration with outer painting, toxic and side effects as serious in hormone medicine, common Chinese drug effect is not good, the more important thing is that medicines of some treatment chloasma are inapplicable etc. to allergic skin, in order to remove the vexation of chloasma to women, we are in conjunction with modern Chinese medicine theory, pay attention to the treatment of chloasma Local Differentiation of Syndromes, take into account the effects such as chloasma treatment and skin lesion reparation, the plant compound gel of invention treatment chloasma.

Summary of the invention

Object: for solving the deficiencies in the prior art, the invention provides a kind of plant compound gel for the treatment of chloasma, there is natural plant active component, determined curative effect, have no side effect, not easily recur, have effect of dispelling spots, collection natural plant active elite, energy is speckle dispelling rapidly, improve color of the leather, recover skin effect.

Technical scheme: for solving the problems of the technologies described above, the technical solution used in the present invention is:

Treat a plant compound gel for chloasma, comprise natural plant component, described natural plant component and parts by weight are: Radix Salviae Miltiorrhizae 15-25 part, Herba Ecliptae 15-25 part, Poria 15-25 part, Aloe 15-25 part, Radix Scutellariae 10-25 part.

Described a kind of plant compound gel for the treatment of chloasma, it is characterized in that, the preparation method of described natural plant component is as follows: by Radix Salviae Miltiorrhizae, Herba Ecliptae, Poria, Aloe, Radix Scutellariae natural plants, according to above-mentioned formula proportion, fully mix, then dry under the high temperature of 50-70 DEG C, make its Temperature fall to room temperature, and use equipment that mixture is crushed to 60-80 order, and become pulverulent mixture, stand-by; Then be placed on by the pulverulent mixture of drying after soaking 24 hours with 70% alcohol-water of 5-10 times of volume in pot or tank body, then extract with 70% alcohol-water, dry ethanol extraction, obtains natural plant extracts A.

Described a kind of plant compound gel for the treatment of chloasma, comprise natural plant extracts A prepared by described natural plant component, also comprise substrate, the component of described substrate and parts by weight are: Acritamer 940 is 10-20 part, glycerol 50-250 part, ethanol 25-75 part, tween 80 10-25 part, laurocapram 2-5 part, ethyl hydroxybenzoate 5-10 part, propylparaben 5-10 part, triethanolamine 5-10 part, surplus are deionized water, and each composition weight summation is 1000 parts.

Above-mentioned a kind of preparation method for the treatment of the plant compound gel of chloasma, comprises the steps:

(1) in the first mixing kettle, add that Acritamer 940 is 10-20 part, glycerol 30-110 part makes it moistening, stir and furnishing pasty state, add deionized water 100-150 part, stir, soak, place 24h and make it fully swelling, stir 2-4 hour, obtains Blank gel substrate, i.e. B liquid for subsequent use;

(2) in the second mixing kettle, add natural plant extracts A, ethanol 25-75 part, glycerol 20-140 part, tween 80 10-25 part, deionized water 100-150 part, laurocapram 2-5 part, ethyl hydroxybenzoate 5-10 part, propylparaben 5-10 part, stir 2-4 hour, obtains active skull cap components mixed solution C liquid;

(3) then active skull cap components mixed solution C liquid is slowly added in above-mentioned Blank gel substrate B liquid for subsequent use, stir, active skull cap components mixed solution is made to be dispersed in gel-type vehicle B liquid, finally add triethanolamine 5-10 part well-beaten simultaneously, adjust ph makes gel, add deionized water to 1000 part, continue to stir 1 hour, the plant compound gel of chloasma must be treated.

Radix Salviae Miltiorrhizae has blood circulation promoting and blood stasis dispelling, and clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle; Herba Ecliptae has liver and kidney tonifying and cooling blood for hemostasis effect; Poria has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming; Aloe has the cool liver of heat clearing away, the effects such as relieving constipation by purgation; Radix Scutellariae has hepatic cholagogic effect.The selected medicament composing prescription of the present invention, its drug component, through dialectical compatibility, complements each other using, has synergism, reach treating both the principal and secondary aspects of a disease to the treatment of chloasma.

Beneficial effect: a kind of plant compound gel for the treatment of chloasma provided by the invention and preparation method thereof, there is natural plant active component, by the gel that the formula provided and preparation method are made, all can be with the use of with the medicine of any common treatment chloasma, be applicable to any skin, and without anaphylaxis, have no side effect, make medicine can infiltrate skin rapidly, reach the object for the treatment of chloasma, determined curative effect, not easily recur, there is functions of removing chloasma effect, collection natural plant active elite, energy is energy speckle dispelling rapidly rapidly, improve color of the leather, recover skin effect.

Detailed description of the invention

Below in conjunction with example, the present invention is illustrated:

Embodiment 1: a kind of plant compound gel for the treatment of chloasma, comprises natural plant component, and described natural plant component and parts by weight are: Radix Salviae Miltiorrhizae 20 parts, Herba Ecliptae 20 parts, 20 parts, Poria, Aloe 15 parts, Radix Scutellariae 25 parts.The preparation method of described natural plant component is as follows: by Radix Salviae Miltiorrhizae, Herba Ecliptae, Poria, Aloe, Radix Scutellariae natural plants, according to above-mentioned formula proportion, abundant mixing, then dry under 50-70 DEG C of high temperature, make its Temperature fall to room temperature, and use equipment that mixture is crushed to 60-80 order, and become pulverulent mixture, stand-by; Then be placed on by the pulverulent mixture of drying after soaking 24 hours with 5-10 times of volume 70% alcohol-water in pot or tank body, then extract with 70% alcohol-water, dry ethanol extraction, obtains natural plant extracts A1.

A kind of plant compound gel for the treatment of chloasma, comprise natural plant extracts A1 prepared by described natural plant component, also comprise substrate: Acritamer 940 is 10 parts, glycerol 90 parts, ethanol 25 parts, tween 80 10 parts, laurocapram 2 parts, ethyl hydroxybenzoate 5 parts, propylparaben 5 parts, triethanolamine 5 parts, deionized water 848 parts.

Described a kind of preparation method for the treatment of the plant compound gel of chloasma, comprise the steps: that (1) adds in the first mixing kettle that Acritamer 940 is 10 parts, glycerol 50 parts makes it moistening, stir and furnishing pasty state, add deionized water 120 parts, stir, soak, placing 24h makes it fully swelling, stir 2-4 hour, obtains Blank gel substrate, i.e. B liquid for subsequent use; (2) in the second mixing kettle, add natural plant extracts A1, ethanol 25 parts, glycerol 40 parts, tween 80 10 parts, deionized water 100 parts, laurocapram 2 parts, ethyl hydroxybenzoate 5 parts, propylparaben 5 parts, stir 2-4 hour, obtains active skull cap components mixed solution C liquid; (3) then active skull cap components mixed solution C liquid is slowly added in above-mentioned Blank gel substrate B liquid for subsequent use, stir, make active skull cap components mixed solution be dispersed in gel-type vehicle B liquid, finally add triethanolamine 5 parts well-beaten, adjust ph makes gel simultaneously, add deionized water to 1000 part, continue to stir 1 hour, stop to stirring, discharging, subpackage, must treat the plant compound gel of chloasma.

Embodiment 2 to embodiment 4:

By the preparation method repeating natural plant component in EXPERIMENTAL EXAMPLE 1 with the natural plant component content of specifying in following table 1, obtain the natural plant extracts A1 of different component content respectively to natural plant extracts A4.

Table 1

Repeat the preparation method for the treatment of the plant compound gel of chloasma in EXPERIMENTAL EXAMPLE 1 by with each constituent content of specifying in following table 2, obtain product 1 to the product 4 of different component content respectively.

Component (part)	Embodiment 1	Embodiment 2	Embodiment 3	Embodiment 4
					Natural plants	Extracted form natural plant	Natural plants is carried	Natural plants is carried	Natural plants is carried

Extract A	Thing A1	Get thing A2	Get thing A3	Get thing A4
					Acritamer 940	10	15	20	15
Glycerol	90	50	150	250
					Ethanol	25	75	50	25
Tween 80	10	20	15	10
					Laurocapram	2	5	3	4
Ethyl hydroxybenzoate	5	10	7	9
					Propylparaben	5	10	7	9
Triethanolamine	5	10	7	9
					Deionized water	848	805	741	669
	Product 1	Product 2	Product 3	Product 4

Due in the plant compound gel of this treatment chloasma, except natural plant extracts, it is little that other are the impact of substrate accessory formula on product efficacy, therefore, at this, the concrete proportion of composing of other substrate adjuvant components in right amount, as those skilled in the art, the proportioning amount of selecting of adjuvant can be grasped, and illustrates no longer one by one.

By a kind of plant compound gel for the treatment of chloasma obtained in embodiment 1 to embodiment 4 and preparation method thereof product 1 to product 4, with existing product for resolving poxes carry out clinical experiment contrast, experimental result is as shown in table 3:

Table 3

	Existing product	Product 1	Product 2	Product 3	Product 4
						Treatment natural law (my god)	90	30	25	30	25
Cure rate (%)	40	96	98	97.5	97.5

Anaphylaxis (%)	30	0	0	0	0
						Recurrence probability (%)	40	6	7	6	10

To 120 people's clinical trials, average cure rate is 97.5%, wherein:

Be less than 9 people's recoveries from illness of 25 years old; 26-30 year 30 people in 22 people recovery from illness, wherein 1 Genus Homo anaphylaxis is failed to respond to any medical treatment; 31-35 year 25 people recovery from illness, wherein 1 is invalid because taking contraceptive; 35-40 year 24 people recovery from illness; 41-45 year 21 people recovery from illness; 46-50 year 10 people recovery from illness; Be greater than 9 people's recoveries from illness of 50 years old; All without anaphylaxis phenomenon.

Usage and consumption: be applied in affected part, application area is good to be greater than ill area, for not affecting patient work or study, can utilize treat, warm water cleaning after getting up morning the length of one's sleep in the evening.

The course for the treatment of: must not be less than 14 days, treatment time puts in place, can not rebound after healing.

Can find out; a kind of plant compound gel for the treatment of chloasma that the invention provides and prepare and preparation method thereof; there is treatment chloasma, repair skin effect; can kill fast and make skin speckle lightization, after two courses for the treatment of, thoroughly can eradicate chloasma, after not multiple after removing; there is good decolouring repair; have no side effect, there is protection skin, recover skin effect.

Below disclose the present invention with preferred embodiment, so it is not intended to limiting the invention, and all employings are equal to replacement or the technical scheme that obtains of equivalent transformation mode, all drop within protection scope of the present invention.

Claims (4)

1. treat a plant compound gel for chloasma, comprise natural plant component, described natural plant component and parts by weight are: Radix Salviae Miltiorrhizae 15-25 part, Herba Ecliptae 15-25 part, Poria 15-25 part, Aloe 15-25 part, Radix Scutellariae 10-25 part.

2. a kind of plant compound gel for the treatment of chloasma according to claim 1, it is characterized in that, the preparation method of described natural plant component is as follows: by Radix Salviae Miltiorrhizae, Herba Ecliptae, Poria, Aloe, Radix Scutellariae natural plants, according to above-mentioned formula proportion, fully mix, then dry under the high temperature of 50-70 DEG C, make its Temperature fall to room temperature, and use equipment that mixture is crushed to 60-80 order, and become pulverulent mixture, stand-by; Then be placed on by the pulverulent mixture of drying after soaking 24 hours with 70% alcohol-water of 5-10 times of volume in pot or tank body, then extract with 70% alcohol-water, dry ethanol extraction, obtains natural plant extracts A.

3. a kind of plant compound gel for the treatment of chloasma according to claim 2, comprise natural plant extracts A prepared by described natural plant component, also comprise substrate, the component of described substrate and parts by weight are: Acritamer 940 is 10-20 part, glycerol 50-250 part, ethanol 25-75 part, tween 80 10-25 part, laurocapram 2-5 part, ethyl hydroxybenzoate 5-10 part, propylparaben 5-10 part, triethanolamine 5-10 part, surplus are deionized water, and each composition weight summation is 1000 parts.

4. a kind of preparation method for the treatment of the plant compound gel of chloasma according to claim 3, comprises the steps:

(1) in the first mixing kettle, add that Acritamer 940 is 10-20 part, glycerol 30-110 part makes it moistening, stir and furnishing pasty state, add deionized water 100-150 part, stir, soak, place 24h and make it fully swelling, stir 2-4 hour, obtains Blank gel substrate, i.e. B liquid for subsequent use;

(2) in the second mixing kettle, add natural plant extracts A, ethanol 25-75 part, glycerol 20-140 part, tween 80 10-25 part, deionized water 100-150 part, laurocapram 2-5 part, ethyl hydroxybenzoate 5-10 part, propylparaben 5-10 part, stir 2-4 hour, obtains active skull cap components mixed solution C liquid;

(3) then active skull cap components mixed solution C liquid is slowly added in above-mentioned Blank gel substrate B liquid for subsequent use, stir, active skull cap components mixed solution is made to be dispersed in gel-type vehicle B liquid, finally add triethanolamine 5-10 part well-beaten simultaneously, adjust ph makes gel, add deionized water to 1000 part, continue to stir 1 hour, the plant compound gel of chloasma must be treated.