Plant compound gel of a kind of Acne treatment and preparation method thereof
Technical field
The present invention relates to plant compound gel of a kind of Acne treatment and preparation method thereof, belong to medical cosmetic field.
Background technology
Acne is a kind of chronic inflammatory disease of hair follicle sebaceous gland, is the modal inflammatory dermatosis of adolescence, be apt to occur in buccal, forehead, buccal and nasolabial fold, and secondly be chest, back and shoulder.Its morbidity is main and sex hormone level, sebaceous gland are secreted in a large number, propionibacterium acnes propagation, the factor analysis such as the dyskeratosis of pilosebaceous duct and inflammation.Hebetic skin surface lipide component changes to some extent, and androgen increases, and causes sebum hair follicle conduit hyperkeratosis, and the epithelial cell that comes off on the follicular wall mixes with sebum, and thromboembolism forms acne in follicular orifice.Be subjected to again the effects such as bacterium acidi propionici (corynebacterium acnes), add that antibacterial infects, cause inflammation, produce abscess, unusually painful after the trouble.
Modern Chinese medicine is thought: acne is because human body sun heat is contained partially, and the lung meridian intrinsic heat is subjected to ailment said due to cold or exposure again, or the pungent delicious food savoury of surfeit, or deficiency of spleen-QI, the reasons such as dysfunction of the spleen in transportation and transformation, and acne is divided into wind and heat in the lung meridian, the intestines and stomach are damp and hot, the phlegm-damp stasis of blood stagnates three kinds of pattern of syndrome.The medicine that many Acne treatments are arranged in the market, have for oral administration and be coated with outward, the toxic and side effects serious such as hormone medicine, the common Chinese drug effect is not good, scar, medicine that the more important thing is some Acne treatments is to allergic skin and inapplicable etc., in order to remove acne to the vexation of countless youth of both sexes, we are theoretical in conjunction with modern Chinese medicine, pay attention to the treatment of acne Local Differentiation of Syndromes, take into account the effects such as acne treatment and skin lesion reparation, the plant compound gel of invention Acne treatment.
Summary of the invention
Purpose: for solving the deficiencies in the prior art; the invention provides a kind of plant compound gel of Acne treatment, have natural plant active component; determined curative effect, have no side effect, be difficult for recurrence; have the anti-acne trace effect that disappears, the active elite of collection natural plants can be antibacterial rapidly; skin ulcer is treated in detoxifcation; can improve color of the leather, recover skin, protection skin.
Technical scheme: for solving the problems of the technologies described above, the technical solution used in the present invention is:
A kind of plant compound gel of Acne treatment comprises natural plant component, and described natural plant component and parts by weight are: Radix Sophorae Flavescentis 20-30 part, Cortex Moutan 15-25 part, Aloe 10-20 part, Radix Scutellariae 10-20 part, Radix Glycyrrhizae 15-25 part.
The plant compound gel of described a kind of Acne treatment, it is characterized in that, the preparation method of described natural plant component is as follows: with Radix Sophorae Flavescentis, Cortex Moutan, Aloe, Radix Scutellariae, Radix Glycyrrhizae natural plants, according to above-mentioned formula proportion, fully mix, then under 50-70 ℃ high temperature, dry, make it naturally cool to room temperature, and use equipment is crushed to the 60-80 order to mixture, becomes pulverulent mixture, and is stand-by; Then after the pulverulent mixture of drying being placed in pot or the tank body 70% alcohol-water with 5-8 times of volume and soaking 24 hours, extract with 70% alcohol-water again, dry must ethanol extraction, be natural plant extracts A of the present invention.
The plant compound gel of described a kind of Acne treatment, the natural plant extracts A that comprises described natural plant component preparation, also comprise substrate, the component of described substrate and parts by weight are: Acritamer 940 is that 15-25 part, glycerol 80-220 part, ethanol 25-100 part, Tween 80 10-20 part, laurocapram 2-5 part, methyl hydroxybenzoate 5-10 part, propylparaben 5-10 part, surplus are deionized water, and each composition weight summation is 1000 parts.
The preparation method of the plant compound gel of described a kind of Acne treatment comprises the steps:
(1) adding Acritamer 940 in the first mixing kettle is that 15-25 part, glycerol 40-110 part make it moistening, stirs and the furnishing pasty state, adds deionized water 120-150 part, stir, soak, place 24h and make its abundant swelling, stirred the white gel substrate of having leisure, i.e. B liquid for subsequent use 2-4 hour;
(2) in the second mixing kettle, add natural plant extracts A, ethanol 25-100 part, glycerol 40-110, Tween 80 10-20 part, deionized water 100-150 part, laurocapram 2-5 part, methyl hydroxybenzoate 5-10 part, propylparaben 5-10 part, stirred 2-4 hour, and got active skull cap components mixed solution C liquid;
(3) then active skull cap components mixed solution C liquid is slowly added in the above-mentioned blank gel-type vehicle B liquid for subsequent use, stir, the active skull cap components mixed solution is dispersed in the gel-type vehicle B liquid, add simultaneously triethanolamine 5-10 part well-beaten at last, regulate pH value and make gel, add deionized water to 1000 part, continued to stir 1 hour, get the plant compound gel of Acne treatment.
Beneficial effect: plant compound gel of a kind of Acne treatment provided by the invention and preparation method thereof; has natural plant active component; the gel of making by the prescription that provides and preparation method; all can be used with the medicine of any common treatment anti-acne; be applicable to any skin, and without the allergy reaction, have no side effect; make medicine can infiltrate rapidly skin; reach the purpose of Acne treatment, determined curative effect; be difficult for recurrence, have the anti-acne trace effect that disappears; the active elite of collection natural plants; can be antibacterial rapidly, skin ulcer is treated in detoxifcation, can improve color of the leather; recover skin, protection skin.
The specific embodiment
Below in conjunction with example the present invention is done and to specify:
Embodiment 1: a kind of plant compound gel of Acne treatment, comprise natural plant component, and described natural plant component and parts by weight are: 20 parts of Radix Sophorae Flavescentiss, 25 parts of Cortex Moutans, 15 parts of Aloes, 20 parts of Radix Scutellariae, 20 parts in Radix Glycyrrhizae.
The preparation method of described natural plant component is as follows: with Radix Sophorae Flavescentis, Cortex Moutan, Aloe, Radix Scutellariae, Radix Glycyrrhizae natural plants, according to above-mentioned formula proportion, fully mix, then under 50-70 ℃ high temperature, dry, make it naturally cool to room temperature, and use equipment is crushed to the 60-80 order to mixture, becomes pulverulent mixture, and is stand-by; Then after the pulverulent mixture of drying being placed in pot or the tank body 70% alcohol-water with 5-8 times of volume and soaking 24 hours, extract with 70% alcohol-water again, dry must ethanol extraction, be natural plant extracts A1 of the present invention.
A kind of plant compound gel of Acne treatment, comprise the natural plant extracts A1 of described natural plant component preparation, also comprise substrate: Acritamer 940 is 15 parts, 80 parts of glycerol, 25 parts of ethanol, 10 parts of Tween 80s, 2 parts of laurocaprams, 5 parts of methyl hydroxybenzoates, 5 parts of propylparaben, 853 parts of deionized waters.
The preparation method of the plant compound gel of described a kind of Acne treatment, comprise the steps: that (1) adds Acritamer 940 is that 80 parts of 15 parts, glycerol make it moistening in the first mixing kettle, stir and the furnishing pasty state, add 120 parts of deionized waters, stir, soak, place 24h and make its abundant swelling, stirred the white gel substrate of having leisure, i.e. B liquid for subsequent use 2-4 hour; (2) in the second mixing kettle, add natural plant extracts A1,25 parts of ethanol, glycerol 40,10 parts of Tween 80s, 100 parts of deionized waters, 2 parts of laurocaprams, 5 parts of methyl hydroxybenzoates, 5 parts of propylparaben, stirred 2-4 hour, and got active skull cap components mixed solution C liquid; (3) then active skull cap components mixed solution C liquid is slowly added in the above-mentioned blank gel-type vehicle B liquid for subsequent use, stir, the active skull cap components mixed solution is dispersed in the gel-type vehicle B liquid, at last at well-beaten 5 parts of the triethanolamine that add simultaneously, regulates pH value and make gel, add deionized water to 1000 part, continued to stir 1 hour, and stopped to stirring discharging, packing gets the plant compound gel of Acne treatment.
Embodiment 2 to embodiment 4:
Preparation method by natural plant component among the natural plant component content repeated experiments embodiment 1 of appointment in the following table 1 obtains respectively the natural plant extracts A1 of different component content to natural plant extracts A4.
Table 1
Preparation method by the plant compound gel of Acne treatment among each constituent content repeated experiments embodiment 1 of appointment in the following table 2 obtains respectively the product 1 of different component content to product 4.
Because in the plant compound gel of this Acne treatment, except natural plant extracts, it is little on the impact of product efficacy that other are the substrate accessory formula, therefore, at this, the concrete proportion of composing of other substrate adjuvant components gets final product in right amount, as those skilled in the art, the proportioning amount of selecting of adjuvant can be grasped, and gives an example no longer one by one.
With the plant compound gel of a kind of Acne treatment of making among the embodiment 1 to embodiment 4 and preparation method thereof product 1 to product 4, with existing product for resolving poxes carry out the clinical experiment contrast, experimental result is as shown in table 3:
Table 3
? |
Existing product |
Product 1 |
Product 2 |
Product 3 |
Product 4 |
The pox that disappears natural law (my god) |
90 |
28 |
20 |
30 |
25 |
Cure rate (%) |
10 |
97 |
98 |
97.5 |
97.5 |
Anaphylaxis (%) |
50 |
0 |
0 |
0 |
0 |
Recurrence probability (%) |
50 |
8 |
6 |
9 |
10 |
To 120 people's clinical trials, average cure rate is 97.5%, wherein:
18 years old 21 people recovery from illness; 24 people recovery from illness among 19 years old 25 people, wherein 1 Genus Homo anaphylaxis is failed to respond to any medical treatment.20 years old 12 people recovery from illness; 21 years old 11 people recovery from illness; 22 years old 8 people recovery from illness; 23 years old 5 people recovery from illness; 24 years old 4 people recovery from illness; 15 people recovery from illness among 25 years old 15 people, wherein 1 is invalid because taking contraceptive; 18 people recovery from illness among 26 years old 19 people is all without irritated reacting phenomenon.
Usage and consumption: be applied in the affected part, application area take greater than ill area as good, for not affecting patient work or study, can utilize treat the length of one's sleep in the evening, the rear warm hot water of getting up morning is cleaned and is got final product.
The course for the treatment of: must not be less than 96 hours, treatment time puts in place, can not rebound after the healing.
Can find out; plant compound gel of a kind of Acne treatment that the invention provides and prepare and preparation method thereof; skin had clean skin, anti-acne, repair; can kill fast epidermis antibacterial and hair follicle root bacillus, can thoroughly eradicate acne, after not answering after the removing; good decolouring repair is arranged; have no side effect, have protection skin, the effectiveness that make skin whitening, attenuate, tenderizes.
Below disclose the present invention with preferred embodiment, so it is not intended to limiting the invention, and all employings are equal to replaces or technical scheme that the equivalent transformation mode obtains, all drops within protection scope of the present invention.