CN1883645A - Composition for treating acne mainly - Google Patents
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- CN1883645A CN1883645A CNA200510081635XA CN200510081635A CN1883645A CN 1883645 A CN1883645 A CN 1883645A CN A200510081635X A CNA200510081635X A CN A200510081635XA CN 200510081635 A CN200510081635 A CN 200510081635A CN 1883645 A CN1883645 A CN 1883645A
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Abstract
The invention discloses a group of compositions mainly for treating acne characterized in that,the compositions comprise the active ingredients of Adapalene and/or aloe and/or bee glue. The compositions have synergic and complementary actions of chemical medicaments and plant medicaments.
Description
Technical field
The present invention relates to one group of compositions that is mainly used in the treatment acne.
Background technology
Acne is commonly called as " acne ", " skin sore ", " comedo " etc.It is one group of common pilosebaceous unit diseases associated with inflammation.Its characteristics are powder, pimple, and pustule, inflammatory tubercle is shown shallow purulence cyst and (extremely serious case) fistula and deeply in inflammation, is formed the purulence cyst sometimes.Get well the vigorous districts of sebum secretion such as a face, chest, back in youth of both sexes.Acne is commonly encountered diseases, the frequently-occurring disease of department of dermatologry, and the sickness rate in the crowd is about 20%～25%, and sickness rate is higher in the crowd of adolescence, be about 30～50%, foreign data is presented among 12～25 years old the crowd sickness rate up to 80%～90%, its cause of disease complexity, course of disease delay.In recent years, along with growth in the living standard, the change of dietary structure, the quickening of work, study rhythm, reasons such as the frequent use of cosmetics and environmental pollution, the sickness rate of primary disease constantly rises.
The pathogenesis of acne is many because of hormone, keratin, the interaction of sebum and antibacterial and cause these factors decision course of disease length and orders of severity.Acne is usually from the pubarche morbidity, and androgen increase this moment increases pilosebaceous unit, and activeness strengthens.The infringement of acne comprises pimple, pustule, tuberosity, cyst.Non-inflammatory lesions comprises the acne (blackhead and hoary hair's acne) of open and closure.
Medicine is the main means of treatment acne, and the medicine of anti-acne is the focus of domestic and international dermatology drug research.
A series of bodies are interior, the external model test shows that adapalene has the stronger dissolving acne effect and the antiinflammatory action of moderate strength.The curative effect of clinical treatment acne vulgaris is similar to tretinoin, but littler than tretinoin to skin irritation.At present be considered to one of most promising class medicine with tretinoin (Ras) Drug therapy acne.But the unstable chemcial property of existing Ras is met light and easily decomposed, and is big to skin irritation during local the use.In order to improve curative effect of medication, increase the stability of chemical property, reduce side effect, tretinoin (RA) has been carried out the research of structure activity relationship, a series of derivants and novel compound have been synthesized, and therefrom filtering out some medicines preferably, adapalene is exactly the new structure medicine of one of them better topical therapeutic acne.Adapalene is one group of novel naphthoic acid derivative, belongs to third generation tretinoin.Adapalene is a category retinol compound, to light, oxidation stability, is one group of inert material.The nuclear retinoic acid receptors of adapalene and the same binding specificity of alltrans tretinoin, but different be that its alternative is incorporated into the tretinoin receptor y relevant with differentiation with the horn cell hypertrophy, do not combine with the endochylema tretinoin is conjugated protein.In Rhino Mus experimental model, the external adapalene has the effect of dissolving acne, and can correct the dyskeratosis of epidermis, thereby stops the generation of homeliness type acne.The mechanism of action of adapalene mainly is by regulating the differentiation of follicular epithelium cell, reducing the formation of micropowder thorn.The while body is interior, experiment in vitro shows that the antiinflammatory action of adapalene is better than other tretinoin medicines.Its anti-inflammatory mechanisms is that the chemotaxis and the arachidonic acid that can suppress human polymorphonuclear leukocyte generate inflammatory mediator through lipid oxidation, and this prompting adapalene acts on inflammatory reaction cell-mediated in the acne.Clinical experiment confirms that also the external adapalene can improve the cutaneous inflammatory lesion of patients with acne, as pimple, abscess.
Adapalene is a kind of new tretinoin derivant of studying in recent years, can be optionally in conjunction with the tretinoin receptor that skin keratin cell enlargement and differentiation is had regulating action, has the effect of receiving thin skin pore, being proved is having better curative effect aspect the treatment acne, then teaching other tretinoin light aspect the side effect such as skin erythema, drying, causalgia, desquamation causing, also is the various bad skins of transformation beauty of present beauty parlor, " advanced weaponry " that coarse skin is bleached attenuate.
Aloe is the perennial evergreen herbaceous plant that originates in Africa, fleshiness, and vitality is extremely strong.In the book of B.C. 1552 ancient Egypts, just put down in writing aloetic usefulness.The tradition that is used for medicinal purpose and improves looks China useful Aloe among the people.Also put down in writing aloetic drug effect in the Compendium of Material Medica.The World Food Programme shows in an investigation of announcing recently, and Aloe content in the contained nutritive value of all wild fruit and vegerable is the highest, just is called as " pharmacy of plant world " because of it has magical medical value since ancient times.Contain compositions such as various saccharides, aminoacid, organized enzyme, aloe-emodin because of it, human body skin there is good moist effect, can quickens skin metabolism, strengthen skin elasticity, make it to seem soft, smooth, plentiful, can also eliminate acne, freckle, chap.Aloe can be improved the quality of skin, and the nutrition skin keeps pale, soft, the elasticity of skin, ruddy gloss, and containing of the cosmetics that market is many all claims to have Aloe on the scale.
Aloetic main effect has: containing tinctura aloes in (1) Aloe, is natural bactericidal antiphlogistic agent, in having and the antidotal effect.(2) the polysaccharide composition in the Aloe can improve body immunity, has regeneration, the protective effect of pair cell tissue, and antiulcer, enhancing viscera function are regulated life entity normalization.In vivo, can nurse one's health endocrine function; External, can brighten sun-proof, reduce wrinkle speckle dispelling, repair skin and water conservation is preserved moisture.Paracytic growth there are very strong inhibition or damage capability, thereby form antitumaous effect.(3) superoxide dismutase in the Aloe (SOD) content is higher, can purify interior free yl, anti-human senescence.
Propolis is to mix the back smectic material that forms in the throat gland fermentation of Apis with saliva by the special composition that Apis is gathered in the resin.Apis is coated whole Nidus Vespae with propolis, and the dark moist Nidus Vespae that makes presents aseptic condition, and pollen, Mel, Lac regis apis can be not corrupt, so research worker claims that propolis is one group " natural antibiotics ".Simultaneously scientist finds that also propolis contains and abundant human body had the important biomolecule material, comprise more than 30 kind of flavone compound, multiple terpenes, 20 several amino acids, multivitamin and active enzyme, 34 kinds of micro elements needed by human and polysaccharide, so human body is had a lot of useful effects, can strengthen natural immunity, competent cell, removal toxin, antiinflammatory, antiallergic, hepatoprotective, blood sugar lowering, blood fat reducing, defying age, inhibition tumor etc.So propolis has " healthy protect god " again, good reputations such as " propolis can be controlled all kinds of diseases and ailments ".Propolis has good antioxidation, remove the free radical effect, and have antiinflammatory, toxin expelling, improvement circulation, endocrine regulation, promotion regeneration, event can eliminate acne, comedo, decomposition pigmented spots, minimizing wrinkle, slow down aging, make the skin reproduction fine and smooth, bright and clean, ruddy.
The medicine of existing treatment acne mostly is folk prescription, acts on more single.The medicine that for example is primarily aimed at the treatment acne mostly is antibiotic, and example hydrochloric acid clindamycin, clindamycin phosphate, erythromycin, xacin-series medicine mainly play the antibiotic antiinflammatory action that has concurrently; And the medicine that is primarily aimed at non-inflammatory acne mostly is tretinoin, salicylic acid, benzoyl peroxide.The main problem that the folk prescription treatment exists is that effect is single, and most medicines have local excitation and irritated effect, as benzoyl peroxide stronger Oxidation is arranged, it is formed the compound preparation quality and is difficult for stable, so the curative effect fluctuation, preservation condition, shelf-life and ease of use etc. all are subjected to drawing more greatly influence.
Summary of the invention
The objective of the invention is to: one group of compositions of mainly treating acne is provided, mostly is folk prescription with the medicine that solves existing treatment acne, therapeutical effect is more single, and the technical problem that shortcomings such as local excitation and/or irritated effect are arranged more.The invention has the advantages that: the present invention is the main component that comprises tretinoin and natural plant beauty treatment category (as Aloe, propolis etc.) treatment acne with the compound preparation form.Can bring into play the collaborative and complementary action of chemicals and medicinal plants simultaneously, take into account the dual function of treatment and beauty treatment, side effect is lower than folk prescription, and patient's compliance is better.
The mechanism of action of adapalene mainly is by regulating the differentiation of follicular epithelium cell, reducing the formation of micropowder thorn.The while body is interior, experiment in vitro shows that the antiinflammatory action of adapalene is better than other tretinoin medicines (Drugs, 2004,64 (13)).Containing tinctura aloes in the Aloe, is natural bactericidal antiphlogistic agent, in having and antidotal effect (" Strait Pharmaceutical Journal ", 2004,16 (1)); The gentle kininase of hydroxyl peptidase in the Aloe has antiinflammatory, promotes the effect (" Strait Pharmaceutical Journal ", 2004,16 (1)) of wound healing; Aloe-emodin has inhibitory action (" Chinese Pharmaceutical ", 2003,12 (8)) to multiple bacillus; Barbaloin has good anti-sunlight function (" Guangzhou chemical industry ", 1997,27 (4)); Superoxide dismutase in the Aloe (SOD) content is higher, can purify interior free yl, and function in delaying senility (" Heilungkiang medicine ", 2002,15 (4)) is arranged; Aloe vera L.var. chinensis(Haw.)Berg. treatment acne vulgaris clinical research (" practical Chinese medicine magazine ", 2003,19 (6)).Domestic and international research shows that propolis has very strong antibacterial action, and Japanese threpsology authority De Yong bravely controls doctor Lang and claims in its works " propolis-natural antibiotics ": " propolis is the material of the known natural antibiosis effect of tool of the mankind ".Utilize the antibiotic property of propolis to treat some disease, major advantage is propolis antimicrobial toxic and side effects as none, also has many other active component in the propolis simultaneously, is of value to early and gets well, and makes therapeutic effect better (" bee magazine ", 2004,3).
With adapalene and/or Aloe and/or propolis composition compound preparation, taken into account the dual function of treatment with beauty treatment, Aloe or propolis will make the side effect of adapalene littler, and the people who is more suitable for various skin matter uses, and enforcement of the present invention will be the Gospel of patients with acne.
The object of the present invention is achieved like this: one group of compositions of mainly treating acne, it is characterized in that: contain following effective active composition (percentage by weight) in the compositions of described main treatment acne: 0.01-0.5% adapalene, 0.5-5% Aloe, 0.5-5% propolis, all the other are excipient.The effective active composition forms gel or ointment or solution or liniment or liniment with after substrate is mixed.This dosage form is in the medicine of preparation treatment acne and the application in the cosmetics (containing caused by cosmetics for special use).
The optimum weight percentage ratio of adapalene composition is 0.1% when preparing above-mentioned various external preparation, and the optimum weight percentage ratio of Aloe composition is 2.0%, and the optimum weight percentage ratio of propolis composition is 1.0%.
The specific embodiment
To further illustrate the present invention in following examples, these embodiment only are used to the present invention is described and to the present invention without limits.
Embodiment
Embodiment 1: adapalene and aloetic compound gel (all percents are percetage by weight)
Adapalene 0.1%
Aloe 2.0%
EDTA 0.5％
Carbomer-940 1%
Glycerol 10%
PEG-400 8％
Triethanolamine 1%
Phenethanol 0.5%
Ethyl hydroxybenzoate 0.2%
Pure water 76.7%
Preparation technology: 1. 1 phase (adapalene (crossing 120 mesh sieves in advance), PEG-400) of recipe quantity in appropriate containers, is ground evenly, stand-by.
2. the EDTA of recipe quantity, Aloe, glycerol, phenethanol, ethyl hydroxybenzoate are added in the pure water of recipe quantity after the dissolving, add carbomer-940, be stirred to all swellings of carbomer-940,2 phases.
3. will handle well 1 be added to 2 mutually in, homogenizing 10 minutes.
4. in the triethanolamine adding 3. with recipe quantity, stirring at low speed got semi-finished product after 1 hour.
5. semi-finished product are through quality inspection, qualified back packing, pack finished product.
Embodiment 2: the compound gel of adapalene and propolis (all percents are percetage by weight)
Adapalene 0.1%
Propolis 1.0%
EDTA 0.5％
Carbomer-940 1%
Glycerol 10%
PEG-400 8％
Triethanolamine 1%
Phenethanol 0.5%
Ethyl hydroxybenzoate 0.2%
Pure water 77.7%
Preparation technology: 1. 1 phase (adapalene (crossing 120 mesh sieves in advance), propolis, PEG-400) of recipe quantity in appropriate containers, is ground evenly, stand-by.
2. the EDTA of recipe quantity, glycerol, phenethanol, ethyl hydroxybenzoate are added in the pure water of recipe quantity after the dissolving, add carbomer-940, be stirred to all swellings of carbomer-940,2 phases.
3. will handle well 1 be added to 2 mutually in, homogenizing 10 minutes.
4. in the triethanolamine adding 3. with recipe quantity, stirring at low speed got semi-finished product after 1 hour.
5. semi-finished product are through quality inspection, qualified back packing, pack finished product.
Embodiment 3: the compound gel of adapalene, Aloe and propolis (all percents are percetage by weight)
Adapalene 0.1%
Aloe 2.0%
Propolis 1.0%
EDTA 0.5％
Carbomer-940 1%
Glycerol 10%
PEG-400 8％
Triethanolamine 1%
Phenethanol 0.5%
Ethyl hydroxybenzoate 0.2%
Pure water 75.7%
Preparation technology: 1. 1 phase (adapalene (crossing 120 mesh sieves in advance), propolis, PEG-400) of recipe quantity in appropriate containers, is ground evenly, stand-by.
2. the EDTA of recipe quantity, Aloe, glycerol, phenethanol, ethyl hydroxybenzoate are added in the pure water of recipe quantity after the dissolving, add carbomer-940, be stirred to all swellings of carbomer-940,2 phases.
3. will handle well 1 be added to 2 mutually in, homogenizing 10 minutes.
4. in the triethanolamine adding 3. with recipe quantity, stirring at low speed got semi-finished product after 1 hour.
5. semi-finished product are through quality inspection, qualified back packing, pack finished product.
Embodiment 4: adapalene and aloetic compound cream agent (all percents are percetage by weight)
Adapalene 0.1%
Aloe 2.0%
EDTA 0.5％
Liquid paraffin 15%
Glyceryl monostearate 10%
Sodium laurylsulfate 10%
Stearyl alcohol 8%
Glycerol 10%
PEG-400 8％
Methyl hydroxybenzoate 0.25%
Propylparaben 0.15%
Pure water 36%
Preparation technology: 1. with the adapalene of recipe quantity (crossing 120 mesh sieves in advance), PEG-400 in appropriate containers, grind evenly, stand-by.Aloe is with after dissolving in an amount of pure water, and is stand-by.Be referred to as 1 phase.
2. the EDTA of recipe quantity, sodium laurylsulfate, glycerol, methyl hydroxybenzoate, propylparaben are added in the pure water of recipe quantity, be heated to 80 ℃ of dissolvings after, 2 phases.
3. after liquid paraffin, glyceryl monostearate, the stearyl alcohol of recipe quantity being heated to 80 ℃ of dissolvings, 3 phases.
4. will handle well 2 be added to 3 mutually in, homogenizing 10 minutes.Be added to 1 when treating that temperature is reduced to 50 ℃ of left and right sides, stirring at low speed is after 1 hour, semi-finished product.
5. semi-finished product are through quality inspection, qualified back packing, pack finished product.
Embodiment 5: the compound cream agent of adapalene and propolis (all percents are percetage by weight)
Adapalene 0.1%
Propolis 1.0%
EDTA 0.5％
Liquid paraffin 15%
Glyceryl monostearate 10%
Sodium laurylsulfate 10%
Stearyl alcohol 8%
Glycerol 10%
PEG-400 8％
Metagin 0.25%
Propylparaben 0.15%
Pure water 37%
Preparation technology: 1. with the adapalene of recipe quantity (crossing 120 mesh sieves in advance), propolis, PEG-400 in appropriate containers, grind evenly, 1 phase, stand-by.
2. the EDTA of recipe quantity, sodium laurylsulfate, glycerol, methyl hydroxybenzoate, propylparaben are added in the pure water of recipe quantity, be heated to 80 ℃ of dissolvings after, 2 phases.
3. after liquid paraffin, glyceryl monostearate, the stearyl alcohol of recipe quantity being heated to 80 ℃ of dissolvings, 3 phases.
4. will handle well 2 be added to 3 mutually in, homogenizing 10 minutes.Be added to 1 when treating that temperature is reduced to 50 ℃ of left and right sides, stirring at low speed is after 1 hour, semi-finished product.
5. semi-finished product are through quality inspection, qualified back packing, pack finished product.
Embodiment 6: the compound cream agent of adapalene, Aloe and propolis (all percents are percetage by weight)
Adapalene 0.1%
Aloe 2.0%
Propolis 1.0%
EDTA 0.5％
Liquid paraffin 15%
Glyceryl monostearate 10%
Sodium laurylsulfate 10%
Stearyl alcohol 8%
Glycerol 10%
PEG-400 8％
Methyl hydroxybenzoate 0.25%
Propylparaben 0.15%
Pure water 35%
Preparation technology: 1. 1 phase (adapalene (crossing 120 mesh sieves in advance), propolis, PEG-400) of recipe quantity in appropriate containers, is ground evenly, stand-by.Aloe is with after dissolving in an amount of pure water, and is stand-by.Be referred to as 1 phase.
2. the EDTA of recipe quantity, sodium laurylsulfate, glycerol, methyl hydroxybenzoate, propylparaben are added in the pure water of recipe quantity, be heated to 80 ℃ of dissolvings after, 2 phases.
3. after liquid paraffin, glyceryl monostearate, the stearyl alcohol of recipe quantity being heated to 80 ℃ of dissolvings, 3 phases.
4. will handle well 2 be added to 3 mutually in, homogenizing 10 minutes.Be added to 1 when treating that temperature is reduced to 50 ℃ of left and right sides, stirring at low speed is after 1 hour, semi-finished product.
5. semi-finished product are through quality inspection, qualified back packing, pack finished product.
Embodiment 7: adapalene and aloetic compound liniment (all percents are percetage by weight)
Adapalene 0.1%
Aloe 2.0%
Pure water 5%
Glycerol 12%
Azone 0.15%
PEG-400 10％
BHT 0.06％
95% ethanol adds to 100.0%
Preparation technology: 1. with the adapalene of recipe quantity (crossing 120 mesh sieves in advance), PEG-400 in appropriate containers, grind evenly, stand-by.Aloe is with after dissolving in the pure water of recipe quantity, and is stand-by.Be referred to as 1 phase.
2. glycerol, azone, the BHT with recipe quantity adds in the ethanol of recipe quantity, after the stirring and dissolving, gets 2 phases.
3. with 1 be added to 2 mutually in, stir after 1 hour, semi-finished product.
4. semi-finished product are through quality inspection, qualified back packing, pack finished product.
Embodiment 8: the compound liniment of adapalene and propolis (all percents are percetage by weight)
Adapalene 0.1%
Propolis 1.0%
Glycerol 12%
Azone 0.15%
PEG-400 10％
BHT 0.06％
95% ethanol adds to 100.0%
Preparation technology: 1. with the adapalene of recipe quantity (crossing 120 mesh sieves in advance), PEG-400 in appropriate containers, grind evenly, 1 phase.
2. propolis, glycerol, azone, the BHT with recipe quantity adds in the ethanol of recipe quantity, after the stirring and dissolving, gets 2 phases.
3. with 1 be added to 2 mutually in, stir after 1 hour, semi-finished product.
4. semi-finished product are through quality inspection, qualified back packing, pack finished product.
Embodiment 9: the compound liniment of adapalene Aloe and propolis (all percents are percetage by weight)
Adapalene 0.1%
Aloe 2.0%
Propolis 1.0%
Pure water 5%
Glycerol 12%
Azone 0.15%
PEG-400 10％
BHT 0.06％
95% ethanol adds to 100.0%
Preparation technology: 1. with the adapalene of recipe quantity (crossing 120 mesh sieves in advance), PEG-400 in appropriate containers, grind evenly, stand-by.Aloe is with after dissolving in the pure water of recipe quantity, and is stand-by.Be referred to as 1 phase.
2. propolis, glycerol, azone, the BHT with recipe quantity adds in the ethanol of recipe quantity, after the stirring and dissolving, gets 2 phases.
3. with 1 be added to 2 mutually in, stir after 1 hour, semi-finished product.
4. semi-finished product are through quality inspection, qualified back packing, pack finished product.
Embodiment 10: adapalene and aloetic compound recipe liniment (all percents are percetage by weight)
Adapalene 0.1%
Aloe 2.0%
Glycerol 9%
Azone 0.15%
PEG-400 6％
Polyvinyl alcohol-124 4.2%
Pure water 35%
95% ethanol adds to 100.0%
Preparation technology: 1. with the adapalene of recipe quantity (crossing 120 mesh sieves in advance), PEG-400 in appropriate containers, grind evenly, stand-by.Aloe is with after dissolving in an amount of pure water, and is stand-by.Be referred to as 1 phase.
2. the glycerol of recipe quantity, polyvinyl alcohol-124 are added fully expand in an amount of pure water after, heating makes dissolving fully in water-bath.
3. with after the ethanol of recipe quantity, the azone stirring and dissolving, will 2. add, stir 2 phases.
4. with 1 be added to 2 mutually in, stir after 1 hour, semi-finished product.
5. semi-finished product are through quality inspection, qualified back packing, pack finished product.
Embodiment 11: the compound recipe liniment of adapalene and propolis (all percents are percetage by weight)
Adapalene 0.1%
Propolis 1.0%
Glycerol 9%
Azone 0.15%
PEG-400 6％
Polyvinyl alcohol-124 4.2%
Pure water 35%
95% ethanol adds to 100.0%
Preparation technology: 1. with the adapalene of recipe quantity (crossing 120 mesh sieves in advance), PEG-400 in appropriate containers, grind evenly, 1 phase.
2. the glycerol of recipe quantity, polyvinyl alcohol-124 are added fully expand in an amount of pure water after, heating makes dissolving fully in water-bath.
3. with after the ethanol of recipe quantity, azone, the propolis stirring and dissolving, will 2. add, stir 2 phases.
4. with 1 be added to 2 mutually in, stir after 1 hour, semi-finished product.
5. semi-finished product are through quality inspection, qualified back packing, pack finished product.
Embodiment 12: the compound recipe liniment of adapalene, Aloe and propolis (all percents are percetage by weight)
Adapalene 0.1%
Aloe 2.0%
Propolis 1.0%
Glycerol 9%
Azone 0.15%
PEG-400 6％
Polyvinyl alcohol-124 4.2%
Pure water 35%
95% ethanol adds to 100.0%
Preparation technology: 1. with the adapalene of recipe quantity (crossing 120 mesh sieves in advance), PEG-400 in appropriate containers, grind evenly, stand-by.Aloe is with after dissolving in an amount of pure water, and is stand-by.Be referred to as 1 phase.
2. the glycerol of recipe quantity, polyvinyl alcohol-124 are added fully expand in an amount of pure water after, heating makes dissolving fully in water-bath.
3. with after the ethanol of recipe quantity, azone, the propolis stirring and dissolving, will 2. add, stir 2 phases.
4. with 1 be added to 2 mutually in, stir after 1 hour, semi-finished product.
5. semi-finished product are through quality inspection, qualified back packing, pack finished product.
Embodiment 13: adapalene and aloetic compound recipe solution (all percents are percetage by weight)
Adapalene 0.1%
Aloe 2.0%
Glycerol 10%
Azone 0.15%
PEG-400 8％
95% ethanol 20%
Pure water adds to 100.0%
Preparation technology: 1. with the adapalene of recipe quantity (crossing 120 mesh sieves in advance), PEG-400 in appropriate containers, grind evenly, stand-by.Aloe is with after dissolving in an amount of pure water, and is stand-by.Be referred to as 1 phase.
2. the azone of recipe quantity, ethanol are added in the appropriate containers, after the stirring and dissolving, add again glycerol, pure water stir 2 phases.
3. with 1 be added to 2 mutually in, stir after 1 hour, semi-finished product.
4. semi-finished product are through quality inspection, qualified back packing, pack finished product.Re-use after noting shaking up.
Embodiment 14: the compound recipe solution of adapalene and propolis (all percents are percetage by weight)
Adapalene 0.1%
Propolis 1.0%
Glycerol 10%
Azone 0.15%
PEG-400 8％
95% ethanol 20%
Pure water adds to 100.0%
Preparation technology: 1. with the adapalene of recipe quantity (crossing 120 mesh sieves in advance), PEG-400 in appropriate containers, grind evenly, 1 phase.
2. the azone of recipe quantity, propolis, ethanol are added in the appropriate containers, after the stirring and dissolving, add again glycerol, pure water stir 2 phases.
3. with 1 be added to 2 mutually in, stir after 1 hour, semi-finished product.
4. semi-finished product are through quality inspection, qualified back packing, pack finished product.Re-use after noting shaking up.
Embodiment 15: the compound recipe solution of adapalene, Aloe and propolis (all percents are percetage by weight)
Adapalene 0.1%
Aloe 2.0%
Propolis 1.0%
Glycerol 10%
Azone 0.15%
PEG-400 8％
95% ethanol 20%
Pure water adds to 100.0%
Preparation technology: 1. with the adapalene of recipe quantity (crossing 120 mesh sieves in advance), PEG-400 in appropriate containers, grind evenly, stand-by.Aloe is with after dissolving in an amount of pure water, and is stand-by.Be referred to as 1 phase.
2. the azone of recipe quantity, propolis, ethanol are added in the appropriate containers, after the stirring and dissolving, add again glycerol, pure water stir 2 phases.
3. with 1 be added to 2 mutually in, stir after 1 hour, semi-finished product.
4. semi-finished product are through quality inspection, qualified back packing, pack finished product.Re-use after noting shaking up.
Claims (7)
1. one group of compositions of mainly treating acne.It is characterized in that, contain following effective active composition (percentage by weight) in the compositions of described main treatment acne: 0.01-0.5% adapalene, 0.5-5% Aloe, 0.5-5% propolis, all the other are excipient.
2. the compositions of main treatment acne as claimed in claim 1 is characterized in that, the effective active composition that the compositions of described main treatment acne contains forms gel or ointment or solution or liniment or liniment with after substrate is mixed.
3. as the compositions of the described main treatment acne of claim 1～2, it is characterized in that the best proportioning that contains effective active composition (percentage by weight) in the compositions of described main treatment acne is: 0.1% adapalene and 2% Aloe.
4. as the compositions of the described main treatment acne of claim 1～2, it is characterized in that the best proportioning that contains effective active composition (percentage by weight) in the compositions of described main treatment acne is: 0.1% adapalene and 1% propolis.
5. as the compositions of the described main treatment acne of claim 1～2, it is characterized in that the best proportioning that contains effective active composition (percentage by weight) in the compositions of described main treatment acne is: 0.1% adapalene, 2% Aloe and 1% propolis.
6. as the application in the medicine of preparation treatment acne of the compositions of the described main treatment acne of claim 1～5.
7. as the application in the cosmetics (containing caused by cosmetics for special use) of preparation treatment acne of the compositions of the described main treatment acne of claim 1～5.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152135B (en) * | 2007-08-30 | 2010-05-19 | 程贵昌 | Natural cleaning agent for human body reproductive organ |
| ITMI20101727A1 (en) * | 2010-09-23 | 2012-03-24 | Forem Pharma S R L | COMPOSITION FOR ACNE TREATMENT. |
| CN102488823A (en) * | 2011-12-26 | 2012-06-13 | 潘洪祥 | Medicine for treating whelk and production method thereof |
| CN103041113A (en) * | 2013-01-22 | 2013-04-17 | 嘉兴萃清堂化妆品有限公司 | Plant compound gel for treating acne and preparation method thereof |
| WO2016136925A1 (en) * | 2015-02-27 | 2016-09-01 | マルホ株式会社 | Composition for skin |
-
2005
- 2005-06-25 CN CNA200510081635XA patent/CN1883645A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152135B (en) * | 2007-08-30 | 2010-05-19 | 程贵昌 | Natural cleaning agent for human body reproductive organ |
| ITMI20101727A1 (en) * | 2010-09-23 | 2012-03-24 | Forem Pharma S R L | COMPOSITION FOR ACNE TREATMENT. |
| CN102488823A (en) * | 2011-12-26 | 2012-06-13 | 潘洪祥 | Medicine for treating whelk and production method thereof |
| CN103041113A (en) * | 2013-01-22 | 2013-04-17 | 嘉兴萃清堂化妆品有限公司 | Plant compound gel for treating acne and preparation method thereof |
| WO2016136925A1 (en) * | 2015-02-27 | 2016-09-01 | マルホ株式会社 | Composition for skin |
| JPWO2016136925A1 (en) * | 2015-02-27 | 2017-12-07 | マルホ株式会社 | Skin composition |
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