CN109481518A - A kind of pharmaceutical composition for treating acne - Google Patents
A kind of pharmaceutical composition for treating acne Download PDFInfo
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- CN109481518A CN109481518A CN201710820472.5A CN201710820472A CN109481518A CN 109481518 A CN109481518 A CN 109481518A CN 201710820472 A CN201710820472 A CN 201710820472A CN 109481518 A CN109481518 A CN 109481518A
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- parts
- extract
- pharmaceutical composition
- acne
- garden burnet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of pharmaceutical compositions with treatment acne, by weight include following compositions: 1-10 parts of Gotu Kola P.E, 1-10 parts of Salvia root P.E, 1-10 parts of garden burnet root extract, 1-10 parts of angelica extract.Composition of the invention uses pure Chinese medicine extract, non-stimulated, and obtains the effect of good treatment acne.
Description
Technical field
The present invention relates to a kind of pharmaceutical compositions, more particularly to a kind of pharmaceutical composition with treatment acne.
Background technique
Acne is a kind of chronic inflammation disease of pilosebaceous follicle that clinic is common.The generation and androgen mistake of acne
High, cortex glandular secretion increases, while making the different hyperkeratinization of hair follicle, sebaceous glands, the flat dead cell fallen wool that cuticula falls off
Capsule pars infundibularis generates mixture in conjunction with sebum.If these mixtures cannot freely be discharged skin surface, and deposit in
Rouge bolt is formed in hair follicle.When these dyskeratosis cell aggregations, lower hopper just forms mature acne when expanding.Sebum quilt
Bacterial decomposition present in hair follicle generates fatty acid, and the latter's hair follicle stimulating causes inflammation, causes follicular wall lesion ruptures,
Hair follicle content enters corium, accordingly, causing the inflammatory reaction of perifollicolar varying degree.
Chinese medicine composition according to the present invention uses pure Chinese medicine extract, non-stimulated, and obtains good treatment acne
Effect.
Summary of the invention
The object of the present invention is to provide a kind of curative for effect, non-stimulated pharmaceutical compositions with treatment acne.
Technical solution of the present invention is summarized as follows:
A kind of pharmaceutical composition with treatment acne, by weight include following components: 1-10 parts of Gotu Kola P.E, Radix Salviae Miltiorrhizae mentions
Take 1-10 parts of object, 1-10 parts of garden burnet root extract, 1-10 parts of angelica extract.
Preferably, Gotu Kola P.E is 8 parts, and Salvia root P.E is 6 parts, and garden burnet root extract is 4 parts, and angelica root extracts
Object is 4 parts.
Gotu Kola P.E is centella alcohol extract, preferred method are as follows: takes centella that the volumetric concentration of 4 mass times is added
It for 30% ethanol water, sets in supersonic wave cleaning machine, 40kHz ultrasound 3 minutes adds the body of suitable 6 mass of centella times
The ethanol water that product concentration is 30%, atmospheric pressure reflux 3 hours, filtrate, spray drying was concentrated in filtration.
Salvia root P.E is Radix Salviae Miltiorrhizae alcohol extract, preferred method are as follows: taking Radix Salviae Miltiorrhizae that the volumetric concentration of 7 mass times is added is 50%
Ethanol water, set in supersonic wave cleaning machine, 40kHz ultrasound 3 minutes adds the volumetric concentration of suitable 8 mass of Radix Salviae Miltiorrhizae times
For 50% ethanol water, atmospheric pressure reflux 3 hours, filtrate, spray drying was concentrated in filtration.
Radix Sangusorbae extract is garden burnet alcohol extract, preferred method are as follows: taking garden burnet that the volumetric concentration of 7 mass times is added is 50%
Ethanol water, set in supersonic wave cleaning machine, 40kHz ultrasound 3 minutes adds the volumetric concentration of suitable 8 mass of garden burnet times
For 50% ethanol water, atmospheric pressure reflux 3 hours, filtrate, spray drying was concentrated in filtration.
Angelica extract is Radix Angelicae Sinensis alcohol extract, preferred method are as follows: taking Radix Angelicae Sinensis that the volumetric concentration of 8 mass times is added is 50%
Ethanol water, set in supersonic wave cleaning machine, at 40kHz ultrasound 3 minutes, the volume for adding suitable 10 mass of Radix Angelicae Sinensis times was dense
The ethanol water that degree is 50%, atmospheric pressure reflux 3 hours, filtrate, spray drying was concentrated in filtration.
Composition of the invention is curative for effect, nonirritant, has no adverse reaction.
Specific embodiment
Further invention is made to the present invention combined with specific embodiments below.
Embodiment 1
A kind of pharmaceutical composition with treatment acne includes following components by weight: 8 parts of Gotu Kola P.E, Radix Salviae Miltiorrhizae extracts
6 parts of object, 4 parts of garden burnet root extract, 4 parts of angelica extract.
Embodiment 2
A kind of pharmaceutical composition with treatment acne includes following components by weight: 1 part of Gotu Kola P.E, Radix Salviae Miltiorrhizae extracts
10 parts of object, 5 parts of garden burnet root extract, 5 parts of angelica extract.
Embodiment 3
A kind of pharmaceutical composition with treatment acne includes following components by weight: 5 parts of Gotu Kola P.E, Radix Salviae Miltiorrhizae extracts
1 part of object, 10 parts of garden burnet root extract, 1 part of angelica extract.
Embodiment 4
A kind of pharmaceutical composition with treatment acne includes following components by weight: 10 parts of Gotu Kola P.E, Radix Salviae Miltiorrhizae extracts
5 parts of object, 1 part of garden burnet root extract, 10 parts of angelica extract.
Embodiment 5
A kind of pharmaceutical composition ointment preparation with anti-acne effect
A phase: water 60g, glycerol 4g, butanediol 4g；
B phase: stearic acid 10g, glycerin monostearate 5g, triethanolamine 1g；
C phase: the composition of embodiment 1
Step 1: above-mentioned respectively weigh A phase, B phase, C phase by quality.
Step 2: the A phase weighed up is thrown into kettle, opens stirring and be warming up to 80 DEG C.
Step 3: the B phase weighed up is put into oil cauldron, opens stirring and be warming up to 80 DEG C.
Step 4: opening emulsion pot stirring (40r/min), vacuumizes, make emulsion pot at negative pressure state, it first will be in oil cauldron
B phase sucks emulsion pot, then the A phase in kettle is sucked in emulsion pot, homogeneous 8 minutes, 3000 revs/min of revolving speed, stirs 30min,
Stop stirring.
Step 5: under vacuum state, 42 DEG C are cooled to hereinafter, C is added in emulsion pot, stirs 15min；
Step 6: taking the dish out of the pot, stand for 24 hours.
The composition of embodiment 2,3,4 prepares corresponding ointment using the above method.
Embodiment 6
Experiment
(1) 80 patients with acne, 16-20 years old age 36 are selected；20-30 years old 30,30-40 years old 14.
(2) method: 80 patients are randomly divided into 5 groups.1,2,3,4 treatment groups use the combination of embodiment 1,2,3,4 respectively
The ointment that object is prepared as described in Example 5, application method are as follows: daily morning and evening with after clear water cleaning face, ointment is uniformly applied
It smears in affected part.1 time a day, it treats 28 days.Control group 16 (is cooled to often using the product that 5 step of embodiment (1)-(4) obtain
Temperature) it is used as blank.Patient, which avoids pungent food, during treatment stimulates food.
(3) it curative effect determinate standard: is drafted according to " disease of tcm Standardization of diagnosis and curative effect " in conjunction with clinic.It cures: skin lesion
Subside, subjective symptoms, which disappears, to improve;Improve: subjective symptoms is substantially reduced, 30% or more skin lesion recession;Be not cured: skin lesion and
Symptom is unchanged or subsides not as good as 30%.
(4) result
Clinical efficacy is shown in Table 1.
Difference is statistically significant (P < 0.05) compared with the control group respectively for 4 groups for the treatment of group's curative effects, and treatment group's curative effect is excellent
In control group.
1 therapeutic effect of table compares
| Group | Number of cases | Healing/example | Effectively/example | In vain/example | Effective percentage/% |
| Treatment group 1 | 16 | 9 | 6 | 1 | 93.75 |
| Treatment group 2 | 16 | 7 | 7 | 2 | 87.50 |
| Treatment group 3 | 16 | 8 | 5 | 3 | 81.25 |
| Treatment group 4 | 16 | 7 | 6 | 3 | 81.25 |
| Control group | 16 | 0 | 2 | 14 | 0.13 |
Claims (2)
1. a kind of pharmaceutical composition with treatment acne, it is characterized in that by weight including following components: Gotu Kola P.E 1-
10 parts, 1-10 parts of Salvia root P.E, 1-10 parts of garden burnet root extract, 1-10 parts of angelica extract.
2. pharmaceutical composition according to claim 1, it is characterized in that the Gotu Kola P.E is 8 parts, Salvia root P.E
It is 6 parts, garden burnet root extract is 4 parts, and angelica extract is 4 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710820472.5A CN109481518A (en) | 2017-09-13 | 2017-09-13 | A kind of pharmaceutical composition for treating acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710820472.5A CN109481518A (en) | 2017-09-13 | 2017-09-13 | A kind of pharmaceutical composition for treating acne |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109481518A true CN109481518A (en) | 2019-03-19 |
Family
ID=65687346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710820472.5A Pending CN109481518A (en) | 2017-09-13 | 2017-09-13 | A kind of pharmaceutical composition for treating acne |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109481518A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115227746A (en) * | 2022-08-23 | 2022-10-25 | 南方医科大学 | Traditional Chinese medicine composition containing salvia miltiorrhiza extract and application thereof |
-
2017
- 2017-09-13 CN CN201710820472.5A patent/CN109481518A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115227746A (en) * | 2022-08-23 | 2022-10-25 | 南方医科大学 | Traditional Chinese medicine composition containing salvia miltiorrhiza extract and application thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190319 |
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| WD01 | Invention patent application deemed withdrawn after publication |