A kind of removing acnes and controlling oil cream and preparation method thereof
Technical field
The present invention relates to a kind of removing acnes and controlling oil creams and preparation method thereof, belong to cosmetic technical field.
Background technique
" whelk " is apt to occur in facial greasiness position, such as cheek, nose front end and two sides, volume, chin etc..Because of " the youth
Acne " is a kind of inflammatory disease of pilosebaceous follicle, and sebaceous glands except palm, arch of the foot etc. in addition to, throughout whole body, being only distributed close
It spends different because of position.Head And Face density highest, therefore the chance for growing " whelk " on the face is most, chest, back, upper limb take second place, lower half
Body is minimum with small leg outer side.Medical research shows that male sex hormone can stimulate exdermoptosis, promotes sebum secretion vigorous, causes
Sebum discharge is excessive, is easy siltation in hair follicle.Follicular wall narrows because of hyperkeratosis, causes sebum discharge to be obstructed, forms rouge
Bolt, that is, Whiteheads is oxidized to form blackhead after ingress of air.So often first there is blackhead in face in early stage acne
Acne.Due to the siltation of sebum, original is present in a kind of intrafollicular propionibacterium acnes (anaerobic bacteria) mass propagation, and generates molten
Lipase, dissolved lipase decompose the triacylglycerol contained in sebum, generate a large amount of free fatty acids, these product hair follicle stimulatings and hair follicle
Nonspecific inflammation reaction occurs for surrounding tissue, and so as to cause inflammation, swelling, pain, itching etc., therefore mid-term acne removes blackhead
Outside acne, there are also warts, papules to occur.
CN105878611A discloses a kind of anti acne of traditional Chinese medicine cream, is the Chinese medicine material composition of following weight proportion: pale reddish brown
Chinese violet 5-7, Korean ginseng 4-6, flower bud of lily magnolia 6-8, root of Dahurain angelica 3-5, aloe 7-9, camellia seed 2-4, open country mountain orchid 4-7, PORIA ALBA 6-9, radix scutellariae
Glycosides 3-5, Rhein 5-7, peppermint grass 6-8, dandelion 2-4, flax benevolence 4-6, caulis clematidis armandii 3-5, Radix Rehmanniae 7-9.CN105833187A
Disclose a kind of plant drug composition with acne-removing and application.Plant drug composition of the invention is by following botanical medicine group
Divide and be made: Radix Salviae Miltiorrhizae, granatum, oldenlandia diffusa, curcuma zedoary, Radix Glycyrrhizae;Botanical medicine is crushed, screening, mixing, after Extraction solvent is added
It impregnates, carries out room temperature extraction with high pressure homogenization method machine, after extracting solution is centrifuged, be concentrated with film, concentrate is with macropore tree
Rouge absorption, then repeatedly eluted with ethyl alcohol, eluent is collected, butanediol dissolution is added after film concentration, botanical medicine combination is made in filtering
Object;Extraction solvent is water, ethyl alcohol or ethanol water.But above-mentioned topical drug and do not have control skin oil and fat secretion
Effect, causes anti-acne effect undesirable.
Summary of the invention
The medicinal external emulsifiable paste agent that the object of the present invention is to provide a kind of using natural plant composition as primary raw material, has
Anti-acne, the effect of oil-control.
Technical solution is:
A kind of removing acnes and controlling oil liniment includes following component by weight: 20~30 parts of witch hazel, chamomile 40~
50 parts, 0.4~0.8 part of Bergamot, 0.4~0.8 part of lemon grass (Cymbopogon citratus) essential oil, 0.3~0.5 part of tea tree ethereal oil, Rosa Damascana 0.2
~0.3 part, 0.1~0.3 part of salicylic acid, 0.05~0.08 part of 'alpha '-hydroxy acids, 12~15 parts of emulsifier, preservative 0.05~0.1
Part, 1~2 part of surfactant, 30~40 parts of consistency modifiers, 50~55 parts of deionized water.
The emulsifier is tristerin.
The preservative is methylparaben.
The surfactant is lecithin.
The consistency modifiers are glycerol or propylene glycol.
The preparation method of the removing acnes and controlling oil liniment, includes the following steps:
Step 1 takes witch hazel and chamomile, after mixing, 5 times of medicinal material weight of water is added, extracts, is mentioned
Liquid is taken, wheat husk powder is added after extracting solution Chinese medicine slag is filtered out, in filtrate and heats up again absorption, after solids is filtered out, obtains medicine
Material decocting liquid;Medicinal material decocting liquid is concentrated under reduced pressure as after thick paste, spray drying is used as extract;
Step 2 after mixing extract, emulsifier, preservative, surfactant, consistency modifiers, heats up and stirs
It is even, Bergamot, lemon grass (Cymbopogon citratus) essential oil, tea tree ethereal oil, Rosa Damascana, salicylic acid, 'alpha '-hydroxy acids, deionized water are added, are stirred
After mixing uniformly, lets cool, obtain cream.
In the step 1, the temperature of extraction is 60~70 DEG C, and extraction time is 1~3h.
In the step 1, the weight of wheat husk powder is the 5~10% of filtrate weight, and adsorption process temperature is 40~50
DEG C, 0.5~1h of adsorption time.
The wheat husk powder refers to Nitric Acid Modified wheat husk powder, and method of modifying is: wheat husk is taken, after being washed, being dried,
It is crushed with pulverizer, sieving;The wheat husk of the nitric acid and certain mass that use 2mol/L again is mixed with the ratio of solid-to-liquid ratio 1:6, first
React 2h under the conditions of 25 DEG C, then be warming up to 75 DEG C the reaction was continued 2h, after be washed with distilled water, filter out solids drying,
To obtain the final product.
In the step 2, the temperature of heating is 50~70 DEG C.
In the present invention, hamamelis extract, camomile extract can infiltrate into pore root, and to acne propionic acid bar
Bacterium has antibacterial and anti-inflammatory effects, and control bacterium generates again;Lemon grass (Cymbopogon citratus) essential oil is used for the raising of skin bacteriostatic activity;Tea tree ethereal oil is used
In anti-inflammatory, oil-control;Salicylic acid has antisepsis and sterilization effect, also dispels the functions such as bad smell of perspiration, relieving itching and eliminating swelling, analgesic antiphlogistic, can be with
The structure formative substance between cutin is dissolved, so that cuticula generation is fallen off, can remove and gather blocked up cuticula, promote the new old of skin
Metabolism;Rosa Damascana is for making skin sedation, promoting cell more raw;'alpha '-hydroxy acids promote the effect of dirt discharge inside pore.
Beneficial effect
The medicinal external emulsifiable paste agent that the present invention is prepared using natural plant composition as primary raw material, with anti-acne, oil-control
Effect.
Specific embodiment
Embodiment 1
Removing acnes and controlling oil liniment includes following component by weight: 20 parts of witch hazel, 40 parts of chamomile, bergamot
0.4 part of essential oil, 0.4 part of lemon grass (Cymbopogon citratus) essential oil, 0.3 part of tea tree ethereal oil, 0.2 part of Rosa Damascana, 0.1 part of salicylic acid, 'alpha '-hydroxy acids
0.05 part, 12 parts of emulsifier tristerin, 0.05 part of preservative methylparaben, 1 part of surfactant lecithin, consistency
30 parts of regulator glycerol, 50 parts of deionized water.
The preparation method of removing acnes and controlling oil liniment, includes the following steps:
Step 1 takes witch hazel and chamomile, after mixing, 5 times of medicinal material weight of water is added, extracts, extraction
Temperature is 60 DEG C, and extraction time is 1h, obtains extracting solution, and after extracting solution Chinese medicine slag is filtered out, wheat husk powder is added again in filtrate
Heating absorption, the weight of wheat husk powder is the 5% of filtrate weight, and adsorption process temperature is 40 DEG C, adsorption time 0.5h, by solid
After object filters out, medicinal material decocting liquid is obtained;Medicinal material decocting liquid is concentrated under reduced pressure as after thick paste, spray drying is used as extract;
Step 2 is warming up to 50 DEG C simultaneously after mixing extract, emulsifier, preservative, surfactant, consistency modifiers
It stirs evenly, adds Bergamot, lemon grass (Cymbopogon citratus) essential oil, tea tree ethereal oil, Rosa Damascana, salicylic acid, 'alpha '-hydroxy acids, deionization
Water is let cool after mixing evenly, obtains cream.
Embodiment 2
Removing acnes and controlling oil liniment includes following component by weight: 30 parts of witch hazel, 50 parts of chamomile, bergamot
0.8 part of essential oil, 0.8 part of lemon grass (Cymbopogon citratus) essential oil, 0.5 part of tea tree ethereal oil, 0.3 part of Rosa Damascana, 0.3 part of salicylic acid, 'alpha '-hydroxy acids
0.08 part, 15 parts of emulsifier tristerin, 0.1 part of preservative methylparaben, 2 parts of surfactant lecithin, consistency
40 parts of regulator glycerol, 55 parts of deionized water.
The preparation method of removing acnes and controlling oil liniment, includes the following steps:
Step 1 takes witch hazel and chamomile, after mixing, 5 times of medicinal material weight of water is added, extracts, extraction
Temperature is 70 DEG C, and extraction time is 3h, obtains extracting solution, and after extracting solution Chinese medicine slag is filtered out, wheat husk powder is added again in filtrate
Heating absorption, the weight of wheat husk powder is the 10% of filtrate weight, and adsorption process temperature is 50 DEG C, adsorption time 1h, by solids
After filtering out, medicinal material decocting liquid is obtained;Medicinal material decocting liquid is concentrated under reduced pressure as after thick paste, spray drying is used as extract;
Step 2 is warming up to 70 DEG C simultaneously after mixing extract, emulsifier, preservative, surfactant, consistency modifiers
It stirs evenly, adds Bergamot, lemon grass (Cymbopogon citratus) essential oil, tea tree ethereal oil, Rosa Damascana, salicylic acid, 'alpha '-hydroxy acids, deionization
Water is let cool after mixing evenly, obtains cream.
Embodiment 3
Removing acnes and controlling oil liniment includes following component by weight: 25 parts of witch hazel, 45 parts of chamomile, bergamot
0.5 part of essential oil, 0.6 part of lemon grass (Cymbopogon citratus) essential oil, 0.4 part of tea tree ethereal oil, 0.25 part of Rosa Damascana, 0.2 part of salicylic acid, 'alpha '-hydroxy acids
0.06 part, 14 parts of emulsifier tristerin, 0.08 part of preservative methylparaben, 2 parts of surfactant lecithin, consistency
35 parts of regulator glycerol, 52 parts of deionized water.
The preparation method of removing acnes and controlling oil liniment, includes the following steps:
Step 1 takes witch hazel and chamomile, after mixing, 5 times of medicinal material weight of water is added, extracts, extraction
Temperature is 65 DEG C, and extraction time is 2h, obtains extracting solution, and after extracting solution Chinese medicine slag is filtered out, wheat husk powder is added again in filtrate
Heating absorption, the weight of wheat husk powder is the 7% of filtrate weight, and adsorption process temperature is 45 DEG C, adsorption time 0.7h, by solid
After object filters out, medicinal material decocting liquid is obtained;Medicinal material decocting liquid is concentrated under reduced pressure as after thick paste, spray drying is used as extract;
Step 2 is warming up to 60 DEG C simultaneously after mixing extract, emulsifier, preservative, surfactant, consistency modifiers
It stirs evenly, adds Bergamot, lemon grass (Cymbopogon citratus) essential oil, tea tree ethereal oil, Rosa Damascana, salicylic acid, 'alpha '-hydroxy acids, deionization
Water is let cool after mixing evenly, obtains cream.
Embodiment 4
The wheat husk powder refers to Nitric Acid Modified wheat husk powder, and method of modifying is: wheat husk is taken, after being washed, being dried,
It is crushed with pulverizer, sieving;The wheat husk of the nitric acid and certain mass that use 2mol/L again is mixed with the ratio of solid-to-liquid ratio 1:6, first
React 2h under the conditions of 25 DEG C, then be warming up to 75 DEG C the reaction was continued 2h, after be washed with distilled water, filter out solids drying,
To obtain the final product.
Removing acnes and controlling oil liniment includes following component by weight: 25 parts of witch hazel, 45 parts of chamomile, bergamot
0.5 part of essential oil, 0.6 part of lemon grass (Cymbopogon citratus) essential oil, 0.4 part of tea tree ethereal oil, 0.25 part of Rosa Damascana, 0.2 part of salicylic acid, 'alpha '-hydroxy acids
0.06 part, 14 parts of emulsifier tristerin, 0.08 part of preservative methylparaben, 2 parts of surfactant lecithin, consistency
35 parts of regulator glycerol, 52 parts of deionized water.
The preparation method of removing acnes and controlling oil liniment, includes the following steps:
Step 1 takes witch hazel and chamomile, after mixing, 5 times of medicinal material weight of water is added, extracts, extraction
Temperature is 65 DEG C, and extraction time is 2h, obtains extracting solution, and after extracting solution Chinese medicine slag is filtered out, Nitric Acid Modified wheat is added in filtrate
Shell powder heats up absorption again, and the weight of wheat husk powder is the 7% of filtrate weight, and adsorption process temperature is 45 DEG C, adsorption time
0.7h after filtering out solids, obtains medicinal material decocting liquid;Medicinal material decocting liquid is concentrated under reduced pressure as after thick paste, spray drying is used as and mentions
Take object;
Step 2 is warming up to 60 DEG C simultaneously after mixing extract, emulsifier, preservative, surfactant, consistency modifiers
It stirs evenly, adds Bergamot, lemon grass (Cymbopogon citratus) essential oil, tea tree ethereal oil, Rosa Damascana, salicylic acid, 'alpha '-hydroxy acids, deionization
Water is let cool after mixing evenly, obtains cream.
Reference examples 1
Difference with embodiment 3 is: Bergamot not being added.
Removing acnes and controlling oil liniment includes following component by weight: 25 parts of witch hazel, 45 parts of chamomile, lemon grass (Cymbopogon citratus)
0.6 part of essential oil, 0.4 part of tea tree ethereal oil, 0.25 part of Rosa Damascana, 0.2 part of salicylic acid, 0.06 part of 'alpha '-hydroxy acids, emulsifier are stearic
14 parts of acid glyceride, 2 parts of surfactant lecithin, 35 parts of consistency modifiers glycerol, is gone at 0.08 part of preservative methylparaben
52 parts of ionized water.
The preparation method of removing acnes and controlling oil liniment, includes the following steps:
Step 1 takes witch hazel and chamomile, after mixing, 5 times of medicinal material weight of water is added, extracts, extraction
Temperature is 65 DEG C, and extraction time is 2h, obtains extracting solution, and after extracting solution Chinese medicine slag is filtered out, wheat husk powder is added again in filtrate
Heating absorption, the weight of wheat husk powder is the 7% of filtrate weight, and adsorption process temperature is 45 DEG C, adsorption time 0.7h, by solid
After object filters out, medicinal material decocting liquid is obtained;Medicinal material decocting liquid is concentrated under reduced pressure as after thick paste, spray drying is used as extract;
Step 2 is warming up to 60 DEG C simultaneously after mixing extract, emulsifier, preservative, surfactant, consistency modifiers
It stirs evenly, adds lemon grass (Cymbopogon citratus) essential oil, tea tree ethereal oil, Rosa Damascana, salicylic acid, 'alpha '-hydroxy acids, deionized water, stir evenly
Afterwards, it lets cool, obtains cream.
Cream pharmacodynamic test:
1, case inclusion criteria:
" clinic skin science ", the second edition, Jiangsu with reference to written by PillSburv and the world improve acne staging, Zhao debates
Science Press.
Involve position according to acne lesions, is classified as I degree (light), II degree (moderate), III degree (severe), IV degree (collection
Cluster):
(light) skin lesion of I degree is blackhead, distributes or multiple inflammatory fash;
II degree (medium) I degree adds superficial running sore, and inflammation number is more, but is only limitted to face;
III degree (weight) II degree is deepened to have tumour in property inflammatory fash, betide face, neck, chest and back;
IV degree (severe-cluster) III degree adds tumour, easily formation scar, betides above the waist.
2, treatment method and the course for the treatment of:
With warm water and face cleaning clothes cleaning face, takes appropriate cream to be applied on skin, gently rub 5min, washed away after 2h.
2 times a day, 30 days as a treatment course.
3, subject:
Selected case totally 80, wherein male 45, female 35, oldest 36 years old, 11 years old minimum, it is 24.5 years old average;
The course of disease is most 3 weeks short, and longest 7 years.It is treated using the cream in embodiment 3, embodiment 4, reference examples 1, separately uses glycerol
As blank control.Every group 20.
Before treatment, treatment after after 30 days progress clinical scores.The method of scoring is by clinical manifestation inflammation papule.Purulence
Blister is pressed without -0, light -1, in -2, weight -3 is added up both after scoring as Clinical scores;
Clinical improvements rate after treatment=(score after score-treatment before treating)/score × 100% before treating.
Efficacy determination: 4 grade standards are used
Recovery clinical improvement rate >=95%;
Effective clinical improvement rate<95%,>=60%
Effective clinical improvement rate<60%,>=20%
Invalid clinical improvement rate < 20%;
Recovery from illness plus effective and effectively add up to effective percentage.
As can be seen from the above table, cream provided by the invention with therapeutic effect for defining when treating acne
The advantages of, embodiment 3 joined Bergamot relative to 1 group of reference examples, the effect of anti-inflammatory oil-control is effectively produced, into
Increase drug effect to one step.
The skin oil and fat content that the measurement of skin oil and fat content is produced using Courage+Khazaka (CK) company of Germany
Tester Sebumeter is surveyed 3 times and is averaged, and every group 20 are done average computation again.
# is relative to blank control group P < 0.05, and * is relative to embodiment P < 0.05
As can be seen from the table, cream provided by the invention has preferable Controlling oil effect, by making for course for the treatment of
With later, skin oil and fat content decreased significantly compared with blank control group.
The granularity of emulsifiable paste is by the Pharmacopoeia of the People's Republic of China (version in 2010) second, and the first method of annex IXE is (micro-
Mirror method) measurement.
Detection data is as follows:
|
Embodiment 1 |
Embodiment 2 |
Embodiment 3 |
Embodiment 4 |
Reference examples 1 |
Granularity |
≤120μm |
≤120μm |
≤120μm |
≤60μm |
≤200μm |
As can be seen from the table, have the advantages that uniform and smooth in the emulsifiable paste that the present invention is prepared, skin be suitble to use,
And can coat uniformly, embodiment 4 is modified wheat husk relative to embodiment 3, can more absorb impurity, avoid
Influence of the impurity for cream granularity.