CN1236801C - Licorice root compound for treating acne - Google Patents
Licorice root compound for treating acne Download PDFInfo
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- CN1236801C CN1236801C CN 200410003429 CN200410003429A CN1236801C CN 1236801 C CN1236801 C CN 1236801C CN 200410003429 CN200410003429 CN 200410003429 CN 200410003429 A CN200410003429 A CN 200410003429A CN 1236801 C CN1236801 C CN 1236801C
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- 150000001875 compounds Chemical class 0.000 title 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 title 1
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- 239000002537 cosmetic Substances 0.000 claims abstract description 12
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
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- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a medicine composition used for treating or preventing acne, wherein the medicine composition contains liquoric root, dahurian angelica, baical skullcap root, honeysuckle flower, rhubarb and aloe. The medicine composition is preparated into ointments, lotions and spraying agents after extraction, and is used as medicine or facial beautification cosmetic for external application.
Description
Technical field
The present invention relates to be used to prevent and treat the medicine or the cosmetics of acne.The external preparation of making of plant amedica such as Radix Glycyrrhizaes specifically.
Background technology
Acne is a kind of disease common in population of adolescent.Its essence is the chronic inflammatory disease of hair follicle, sebaceous gland, leaves over depressed scar and temporary pigmentation after the inflammatory pimple disappears easily, influences appearance when serious, and especially the acne conglobata obstinate brings psychic pain to the patient.
Medical circle also lacks effective measures to the prevention of acne at present, and remedy of acne is not also had the specially good effect means, each family comprehensive measures such as antiinflammatory, parasite killing, inhibition smegma, raising immunologic function that adopt more.Multiple medicine and naturopathy method are to the visible certain effect of acne, but general curative effects such as cure rate, obvious effective rate are very dissatisfied; The using method that has is loaded down with trivial details, and administration time is very long; Ubiquity relapse rate height or the like defective also.
Summary of the invention
The objective of the invention is to propose a kind of compositions that contains Radix Glycyrrhizae, their extract is used to prepare medicines or cosmetics, and prevention or treatment acne are had positive effect, to keeping the level and smooth exquisiteness of skin certain effect is arranged.
The objective of the invention is to realize by following technical scheme.
The component of medicine of the present invention comprises the Chinese herbal medicine of following percentage by weight:
Radix Glycyrrhizae 20～30% Radixs Angelicae Dahuricae 15～20% Radix Scutellariaes 10～15% Flos Loniceraes 15～25%
Radix Et Rhizoma Rhei 15～20% Aloes 10～15% grams
The preferable amount of each crude drug is expressed as follows with percentage by weight:
Radix Glycyrrhizae 22～28% Radixs Angelicae Dahuricae 16～18% Radix Scutellariaes 12～14% Flos Loniceraes 18～22%
Radix Et Rhizoma Rhei 16～18% Aloes 12～14%
The optimum amount percentage ratio of each crude drug is:
Radix Glycyrrhizae 24% Radix Angelicae Dahuricae 16% Radix Scutellariae 12% Flos Lonicerae 20% Radix Et Rhizoma Rhei 16% Aloe 12%
More than Pei Fang crude drug is plant amedica, can adopt the process of " decocting in water alcohol extraction ", " water logging alcohol extraction " to get fluid extract, adds excipient again and makes dosage forms such as ointment, lotion, spray, makes external preparation for skin.
Can life-time service with topical drug preparation or cosmetics that pharmaceutical composition extract of the present invention is made.Unguentum can evenly be applied in skin of face; Use lotion to dash 3～5 minutes, or soak with towel and to spread on face after inhaling lotion as each the washing that wash one's face; When using spray then with medicine liquid spray in face, treat its natural drying.Use above any dosage form to do the beauty treatment time spent, use 1～2 general every day; When making acne treatment, should increase the medication number of times, general medication every day 3～6 times, logotype 7～14 days was a course of treatment.More than all should clean face before any dosage form medication.
Pharmaceutical formulation of the present invention is not on the books in the classic of TCM, yet not record in patent documentation.The inventor is undertaken dialectical by theory of Chinese medical science according to the ubiquitous symptom of acne, sign, in conjunction with the understanding to the several kinds of Chinese medicinal materials property of medicine, by the types of drugs compatibility, constitute compositions, extracts its active component, makes topical drug or cosmetics.Radix Glycyrrhizae is a principal agent in prescription.Modern study to Radix Glycyrrhizae proves that glycyrrhizin has the function of detoxifcation, anti-inflammatory as most important active component in the Radix Glycyrrhizae.Another kind of important physical active substance in the Radix Glycyrrhizae---licoflavone has the effect and the effect of class adrenocortical hormone of antiinflammatory, antiallergic action, also has the effect of restraint of tyrosinase activity, elimination oxygen-derived free radicals.These pharmacological actions of Radix Glycyrrhizae can alleviate skin to the reaction of androgen, the reparation that helps damaging, and just are being applicable to remedy of acne and prevention, also the senescence process of the slow healthy skin of resistance.
Flos Lonicerae in the present composition has the effect of heat-clearing and toxic substances removing, anti-inflammation; Radix Scutellariae, Radix Et Rhizoma Rhei all are pathogenic fire purging good medicine, and with the Radix Glycyrrhizae compatibility, oral administration and externally all can; The hot detumescence and apocenosis that looses of the Radix Angelicae Dahuricae can strengthen the merit of Radix Glycyrrhizae detoxifcation.These several Chinese medicines form powerful antiinflammatory, Detoxication with Radix Glycyrrhizae.But traditional understanding Aloe external treatment exudative dermatitis, present age understanding Aloe can be used for beauty treatment, and it is combined in when helping prolonged application medicine of the present invention or cosmetics in the prescription maintenance effect to skin.
Be confirmed in the EXPERIMENTAL EXAMPLE that the good result of medicine of the present invention on the treatment acne put down in writing hereinafter.
EXPERIMENTAL EXAMPLE 1 is used unguentum treatment acne
This group is through controlling cases of acne 186 examples.Wherein male 60 examples, women 126 examples; 15～35 years old age; The course of disease 3 months～12 years.The erythra characteristics are that age more little (15～18 years old) inflammatory pimple is light more, are main performance with the blackhead.And 20～35 years old, serve as main performance then with pimple, fester.Site of pathological change is with forehead, and cheeks portion, forehead are main.
This group case is all used the ointment of making by embodiment 3 methods and is made skin massaging.At first clean skin of face before the medication, massaged 5～10 minutes after coating unguentum.Massage can the oneself be carried out, and also can be implemented by other people.Every day, the medication massage was 3 times, and be 7 days 1 course of treatment, observes the statistics therapeutic effect 2 courses of treatment of continuous application (counting 14 days).
Criterion of therapeutical effect: produce effects: the erythra major part disappears, and does not have new erythra and occurs; Effectively: deflorescence does not have new dermexanthesis more than 1/2; Invalid: deflorescence less than 1/2 has new dermexanthesis.
This group patient treatment the results are shown in Table 1.
The therapeutic effect statistics of table 1 186 examples
| Add up to | Produce effects | Effectively | Invalid | |
| Case | 186 | 102 | 81 | 3 |
| Percentage ratio (%) | 100.0 | 54.8 | 43.5 | 1.6 |
EXPERIMENTAL EXAMPLE 2
This experiment is at the purposes of Radix Glycyrrhizae preparation of compositions used for cosmetic of the present invention in beauty treatment.Method is, selects not have women 30 people of dermatosis, and the age is at 23～52 years old, average 34 years old.The spray that application is made by embodiment 4 methods is made skin of face and is sprayed.At first clean skin of face before the medication, the sprinkling amount to be to form current degree of being, allows its natural drying.Spray every day 2 times, continuous 14 days is an observation cycle.
Observational technique is self evaluation and others'evaluation.Carry out observing time in medication stops one week of back.Self evaluation is included in during the medication and medication stops normal threshold of feeling and the difference sensation of back in one week, observes the exquisiteness or the degree of roughness of skin of face, and hands touches the soft degree of skin.Others'evaluation is for observing evaluation." other people " select experimenter's household or colleague, require that first three was in a few days once got along with the experimenter closely in experimenter's medication, and experimenter's appearance is had clear memory.
Self evaluation and others'evaluation all adopt improvement, no change, deterioration to estimate statistics for three grades.Result such as table 2.
Table 2 30 routine cosmetic result statistics
| Add up to | Improve | No change | Worsen | |
| Self evaluation | 30 | 18 | 12 | 0 |
| Others'evaluation | 30 | 14 | 16 | 0 |
Above-mentioned statistics shows, behind the spray cosmetics of using Radix Glycyrrhizae preparation of compositions of the present invention, half many people's self evaluation skin has improvement, others'evaluation have improvement also nearly half.Self evaluation and others'evaluation all do not have the situation of " deterioration " to occur, and the cosmetic result that Radix Glycyrrhizae compositions of the present invention is described is sure.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1
The Radix Glycyrrhizae 600 gram Radixs Angelicae Dahuricae 400 gram Radix Scutellariaes 300 gram Flos Loniceraes 500 gram Radix Et Rhizoma Rhei 400 gram Aloes 300 grams
Above each medicine is broken into coarse grain (3～5 order), adds the cold water soak 48 hours of 5 times of amounts, lixiviating solution is crossed leaching filtrate.Add the cold water soak 24 hours of 3 times of amounts in the filtering residue again, filter once more and obtain filtrate.Merge the filtrate evaporation and concentration twice, the cooling back adds ethanol and placed at low temperatures 48 hours, mixed liquor is filtered once more evaporation and concentration filtrate get the thick extract of brown, and this moment, the extract loss on drying was below 35%.It is standby that extract generates coarse crystallization once more behind the concentrate drying.
Embodiment 2
The Radix Glycyrrhizae 840 gram Radixs Angelicae Dahuricae 450 gram Radix Scutellariaes 360 gram Flos Loniceraes 480 gram Radix Et Rhizoma Rhei 450 gram Aloes 420 grams
Above each medicine is broken into coarse grain (3～5 order), and the clear water that adds 5 times of amounts soaks after 4 hours with 80～90 ℃ of Steam Heating 4 hours, crosses leaching filtrate.The clear water that adds 3 times of amounts in the filtering residue again filters once more and obtains filtrate with 80～90 ℃ of Steam Heating 2 hours.Merge the filtrate evaporation and concentration twice, the cooling back adds ethanol and placed at low temperatures 48 hours, mixed liquor is filtered once more evaporation and concentration filtrate get the thick extract of brown, and this moment, the extract loss on drying was below 35%.Extract generates coarse crystallization behind the concentrate drying once more, and this coarse crystallization being carried out recrystallization in Diluted Alcohol solution, to get highly finished product standby again.
Embodiment 3 preparation ointments
Prescription: drug crystallization 10 gram triethanolamine 20 grams of pressing embodiment 1 preparation
Glycerol 50 gram stearic acid 150 gram lanolines 20 grams
White vaseline 250 gram oxybenzene second fat 1 gram distilled water is added to 1000 grams
Method for making: stearic acid is melted in water-bath, add lanoline and white vaseline and heating in water bath to 80 ℃; It is soluble in water that other gets triethanolamine, glycerol, oxybenzene second fat, is heated to 80 ℃ in water-bath, under constantly stirring oil phase is being added to aqueous phase gradually, stirs condensation and obtain ointment, and the drug crystallization that adds porphyrize at last stirs evenly promptly.
Embodiment 4 preparation sprays
Get drug crystallization 10 grams by embodiment 2 preparation, be ground into fine powder, add about 20 grams of surfactant tween 80, mix homogeneously is put in 1000 milliliters of aqueous solutions that contain antiseptic and tackifier together, is uniformly dispersed, and bottling gets final product.
Embodiment 5 preparation lotions
Get drug crystallization 5 grams, be ground into fine powder, add 95% ethanol, 50 grams, glycerol 25 grams, add water to 1000 milliliters by embodiment 2 preparations.
Claims (6)
1. a pharmaceutical composition that is used for the treatment of or prevents acne is characterized in that, it is made by the following raw material medicines in percentage by weight combination:
Radix Glycyrrhizae 20～30% Radixs Angelicae Dahuricae 15～20% Radix Scutellariaes 10～15% Flos Loniceraes 15～25%
Radix Et Rhizoma Rhei 15～20% Aloes 10～15% grams.
2. the percentage by weight of described each crude drug of pharmaceutical composition of claim 1 is,
Radix Glycyrrhizae 22～28% Radixs Angelicae Dahuricae 16～18% Radix Scutellariaes 12～14% Flos Loniceraes 18～22%
Radix Et Rhizoma Rhei 16～18% Aloes 12～14%.
3. the percentage by weight of described each crude drug of pharmaceutical composition of claim 1 is,
Radix Glycyrrhizae 24% Radix Angelicae Dahuricae 16% Radix Scutellariae 12% Flos Lonicerae 20% Radix Et Rhizoma Rhei 16% Aloe 12%.
4. the application of the described pharmaceutical composition of the arbitrary claim of claim 1～3 in the medicine of preparation treatment or prevention acne.
5. the application of the described pharmaceutical composition of the arbitrary claim of claim 1～3 in the preparation cosmetics.
6. made medicine of the described pharmaceutical composition of the arbitrary claim of claim 1～3 or cosmetics are a kind of dosage forms in ointment, lotion, the spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410003429 CN1236801C (en) | 2004-03-05 | 2004-03-05 | Licorice root compound for treating acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410003429 CN1236801C (en) | 2004-03-05 | 2004-03-05 | Licorice root compound for treating acne |
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| Publication Number | Publication Date |
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| CN1559450A CN1559450A (en) | 2005-01-05 |
| CN1236801C true CN1236801C (en) | 2006-01-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410003429 Expired - Fee Related CN1236801C (en) | 2004-03-05 | 2004-03-05 | Licorice root compound for treating acne |
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100404047C (en) * | 2005-07-22 | 2008-07-23 | 张友生 | Medicinal composition for treating acne and eczema and its preparing method |
| CN1969984B (en) * | 2006-12-07 | 2010-12-29 | 刘爱芹 | Externally applied medicament for treating acne and allergy |
| CN100496447C (en) * | 2007-09-05 | 2009-06-10 | 黑龙江省科学院火山矿泉资源研究所 | Method for preparing cold mineral spring spray |
| CN102908602B (en) * | 2012-11-07 | 2014-01-01 | 南京慧博生物科技有限公司 | Medicinal composition with acne-removing effect and preparation method thereof |
| CN102908411A (en) * | 2012-11-21 | 2013-02-06 | 安文娟 | Ointment for treating acne |
| CN103961277A (en) * | 2014-04-04 | 2014-08-06 | 嘉兴博泰生物科技发展有限公司 | Acne cream containing SOD (superoxide dismutase) and preparation method |
| CN104663890B (en) * | 2015-02-02 | 2018-02-27 | 湖南中医药大学 | A kind of anti-acne Chinese herbal medicine Yoghourt and preparation method thereof |
| CN104814906A (en) * | 2015-05-20 | 2015-08-05 | 湖南中医药大学 | Traditional Chinese medicine effective component and skin care preparation using traditional Chinese medicine effective component as main component |
| CN104984016A (en) * | 2015-06-18 | 2015-10-21 | 梁振权 | Anti-acne antiphlogistine and preparation method thereof |
| CN105662994A (en) * | 2016-01-18 | 2016-06-15 | 罗美香 | Traditional Chinese medicine based oil-control anti-acne moisturizer |
| CN107158294A (en) * | 2017-06-09 | 2017-09-15 | 芦荣朋 | A kind of Chinese medicine composition for repairing skin of face and its preparation method and application |
| CN109394666A (en) * | 2018-12-06 | 2019-03-01 | 广州市诺兰精细化工有限公司 | A kind of face mask of traditional Chinese medicine and preparation method for scytitis |
-
2004
- 2004-03-05 CN CN 200410003429 patent/CN1236801C/en not_active Expired - Fee Related
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