CN108434226A

CN108434226A - It is a kind of treat alopecia areata, alopecia seborrheica antibacterial aqua and preparation method thereof

Info

Publication number: CN108434226A
Application number: CN201810535987.5A
Authority: CN
Inventors: 郑和国
Original assignee: Wuhan Runhe Biological Medical Co Ltd
Current assignee: Wuhan Runhe Biological Medical Co Ltd
Priority date: 2018-05-30
Filing date: 2018-05-30
Publication date: 2018-08-24

Abstract

The invention discloses it is a kind of treat alopecia areata, alopecia seborrheica antibacterial aqua and preparation method thereof, belong to treatment alopecia areata, alopecia seborrheica technical field of pharmaceuticals；Wherein the parts by weight of each component are 25 parts of cacumen biotae, 35 parts of the fleece-flower root, 24 parts of the rhizome of davallia, 13 parts of safflower, 26 parts of frutus cnidii, 47 parts of dittany bark, 26 parts of Rhizoma Chuanxiong, 14 parts of Radix Angelicae Sinensis, 20 40 parts of castor oil, 24 parts of acetic acid chlorhexidine；This product is based on modern Chinese medicine and doctor trained in Western medicine to alopecia areata, the pathogenetic understanding of alopecia seborrheica and principle of reatment, and selected Chinese and western medical raw material is formulated using unique formula, and when treatment, external application can once a day or twice cure for 1~2 month.

Description

It is a kind of treat alopecia areata, alopecia seborrheica antibacterial aqua and preparation method thereof

Technical field

The present invention relates to a kind of antibacterial aqua and preparation method thereof, and in particular to a kind of to treat alopecia areata, alopecia seborrheica Antibacterial aqua and preparation method thereof belongs to treatment alopecia areata, alopecia seborrheica technical field of pharmaceuticals.

Background technology

Alopecia areata is commonly called as " alopecia areata ", is a kind of patchy alopecia trichonosis of the limitation occurred suddenly.Its lesion Scalp is normal, no inflammation and from symptom.This disease course of disease is by that slowly, voluntarily can alleviate and recur.If entire hair of scalp is whole It falls off, claims whole alopecia.Seborrhea hair alopecia claimed " early bald ", " the source property alopecia of hero hair hormone ", disease and heredity, male sex hormone, skin in the past Seborrhea goes out related, and symptom is that scalp fat secretion is excessive, and scalp has greasy feeling, is special with the progressive hair alopecia of forehead and overhead Sign, is more common in the male being engaged in mental work.

Alopecia seborrheica Chinese medicine is known as " seborrheic dermatitis ", and doctor trained in Western medicine is also known as male pattern alopecia, androgenic baldness, and dispersivity is bald Hair is the baldness that neck after puberty, temporo, top are made slow progress, and men and women's both sexes can occur, but more normal with male patient See.It is also one of common disease, frequently-occurring disease and the refractory disease of dept. of dermatology's clinic.Modern medicine more think the occurrence of this disease with Sex hormone dysequilibrium, smegma are excessively related.Clinically this patient often goes out more, scalp with seborrhea capitis Bits are more, the symptoms such as withered, itch of hair.

Since this disease hinders appearance, beauty is influenced, often brings prodigious stress and mental burden to patient, therefore right The treatment of this disease is also particularly important.But alopecia seborrheica and alopecia areata disease are controlled there are no relatively effective at present Treatment method.The common method of modern Western medicine has local topical drug such as：Minoxidil, intracutaneous injection cortex class consolidate ferment, using connecing Tactile sensitizing agent is such as：Dinitrofluorobenzene, photochemotherapy, female hormone therapy etc., though these methods have certain curative effect, has not With the side effect of degree.

The curative effect that traditional Chinese medicine has comparison definite in terms of delaying the development of this disease.Alopecia seborrheica is analyzed from traditional Chinese medicine Pathogenesis, mainly have blood-head wind-dryness, damp heat in the spleen and the stomach, kidney deficiency and liver, stagnation of QI-blood type four broad aspects, disease be in hair follicle, Scalp, for lesion in hair, sick position is dirty in close relations with liver,spleen,kidney three in internal organs.Chinese medicine thinks " hair is the sign of blood condition ", and " hair is Waited except kidney ", the nourishing of hair derives from blood, and root is lost in kidney, asthenia of essence and blood, liver kidney deficiency, breakdown of the normal physiological coordination between the heart and the kidney, and the deficiency of blood cannot be flourish It supports；Multiple because space between skin and muscles is not solid, ailment said due to cold or exposure is taken advantage of a weak point, and causes wind Sheng blood dry, and is sent out to become homeless to support and caused alopecia.The rules for the treatment of are to tonify the liver and kidney, support Blood promoting blood circulation, wind-dispelling rise the methods such as hair.

Invention content

The purpose of the present invention is to solve current alopecia areata, the treatment problems of alopecia seborrheica, and propose a kind of blood-nourishing Promoting blood circulation rises and sends out fat of dispelling, the antibacterial aqua for the treatment of alopecia areata without side-effects, alopecia seborrheica.To achieve the above object, the present invention adopts With following technical solution：

It is a kind of treat alopecia areata, alopecia seborrheica antibacterial aqua, the weight proportion of material composition is as follows：

2-5 parts of cacumen biotae, 3-5 parts of the fleece-flower root, 2-4 parts of the rhizome of davallia, 1-3 parts of safflower, 2-6 parts of frutus cnidii, 4-7 parts of dittany bark, river 2-6 parts of rhizome of chuanxiong, 1-4 parts of Radix Angelicae Sinensis, 20-40 parts of castor oil, 2-4 parts of acetic acid chlorhexidine.

2-3 parts of cacumen biotae, 3-4 parts of the fleece-flower root, 2-3 parts of the rhizome of davallia, 2-3 parts of safflower, 2-4 parts of frutus cnidii, dittany bark 5-7 Part, 4-6 parts of Rhizoma Chuanxiong, 3-4 parts of Radix Angelicae Sinensis, 20-30 parts of castor oil, 2-3 parts of acetic acid chlorhexidine.

3-5 parts of cacumen biotae, 4-5 parts of the fleece-flower root, 3-4 parts of the rhizome of davallia, 1-2 parts of safflower, 4-6 parts of frutus cnidii, dittany bark 4-6 Part, 2-4 parts of Rhizoma Chuanxiong, 1-3 parts of Radix Angelicae Sinensis, 30-40 parts of castor oil, 3-4 parts of acetic acid chlorhexidine.

2-5 parts of cacumen biotae, 3-5 parts of the fleece-flower root, 2-4 parts of the rhizome of davallia, 1-3 parts of safflower, 2-6 parts of frutus cnidii, dittany bark 4-7 Part, 2-6 parts of Rhizoma Chuanxiong, 1-4 parts of Radix Angelicae Sinensis, 20-40 parts of castor oil, 2-4 parts of acetic acid chlorhexidine.

It is a further object to provide it is a kind of treat alopecia areata, alopecia seborrheica antibacterial aqua preparation method, Include the following steps：

（1）By cacumen biotae, the fleece-flower root, the rhizome of davallia, safflower, frutus cnidii, dittany bark, Rhizoma Chuanxiong, Radix Angelicae Sinensis number according to required weight, it is added Into deionized water, after being thoroughly mixed, impregnate 2-3 days；

（2）By step（1）In mixture boiled 10~20 minutes at 200~300 DEG C, the dregs of a decoction are filtered, obtain water extraction Object；

（3）Castor oil and acetic acid chlorhexidine are added in water extract, stirs evenly, antibacterial aqua is obtained after homogeneous.

The pharmacological property of the raw materials used in the present invention is as follows：

Cacumen biotae：Cooling blood and hemostasis, preventing phlegm from forming and stopping coughing rise hair black hair；Nourishing the blood and yin；

The fleece-flower root：Wind-dispelling, removing toxic substances rise hair black hair；

The rhizome of davallia：Kidney tonifying is invigorated blood circulation, hemostasis；

Safflower：It is sweet in flavor, mild-natured, have effects that it is promoting blood circulation and removing blood stasis, dissipate and strongly fragrant open knot；

Frutus cnidii：Eliminating dampness, wind-dispelling, desinsection；

Dittany bark：Heat-clearing and damp-drying drug, wind-dispelling removing toxic substances；

Rhizoma Chuanxiong：Promote breath and open depression, method wind-dryness is wet, promoting blood circulation and stopping pain；

Radix Angelicae Sinensis：Replenishing and activating blood, menstruction regulating and pain relieving relax bowel；

Castor oil purging intense heat, except steaming, detoxification sore treatment；

Chlorhexidine acetate is also Robenidine Roripa, chlorhexidine acetate, Chlorhexidine, double benzyl chloride chlorhexidine, for cation Surfactant, has a broad antifungal spectrum have killing effect to most Grain-positives and negative bacteria, also effective to Pseudomonas aeruginosa, use In operation remote holder, skin, planing surface and sterilization of instruments.

The advantages of the present invention are：This product is with doctor trained in Western medicine based on modern Chinese medicine to alopecia areata, alopecia seborrheica Pathogenetic understanding and principle of reatment, selected Chinese and western medical raw material, are formulated using unique formula, when treatment, external application, Once a day or twice, it can cure within 1~2 month.

Specific implementation mode

Product of the present invention is further described below in conjunction with the embodiment of the present invention, the description of embodiment is only for ease of understanding With with the application of the invention, rather than to the limitation protected of the present invention.Unless stated otherwise, the % in the present invention is mass percent；It removes Non-specifically illustrate, preparation process carries out under room temperature, normal pressure state；Unless stated otherwise, the present invention in use reagent, method It is the art conventional reagent, method and apparatus with equipment；Unless stated otherwise, the experimental condition used in the present invention is this Technical field normal test conditions；Unless stated otherwise, agents useful for same is purchased in market in the present invention.

Embodiment 1

2 parts of cacumen biotae, 5 parts of the fleece-flower root, 2 parts of the rhizome of davallia, 3 parts of safflower, 2 parts of frutus cnidii, 7 parts of dittany bark, 2 parts of Rhizoma Chuanxiong, Radix Angelicae Sinensis 4 Part, 20 parts of castor oil, 4 parts of acetic acid chlorhexidine.

It is a kind of treat alopecia areata, alopecia seborrheica antibacterial aqua preparation method, include the following steps：

Embodiment 2

3 parts of cacumen biotae, 4 parts of the fleece-flower root, 3 parts of the rhizome of davallia, 2 parts of safflower, 4 parts of frutus cnidii, 5 parts of dittany bark, 4 parts of Rhizoma Chuanxiong, Radix Angelicae Sinensis 4 Part, 30 parts of castor oil, 3 parts of acetic acid chlorhexidine.

Embodiment 3

4 parts of cacumen biotae, 45 parts of the fleece-flower root, 34 parts of the rhizome of davallia, 42 parts of safflower, 4 parts of frutus cnidii, 6 parts of dittany bark, 2 parts of Rhizoma Chuanxiong, Radix Angelicae Sinensis 3 parts, 40 parts of castor oil, 3 parts of acetic acid chlorhexidine.

Clinical observation and curative effect

1. general information：

1.1 alopecia seborrheica

The tested case 160 of in January, 2015~2017 year Dermatology Outpatient Department in June, wherein male 88 are collected, women 72 Example；Age is 35~55 years old；Diagnostic criteria：1. grease was more, dandruff is more, scalp pruritus, and with continuous alopecia 3 months, daily Alopecia quantity 50 or more；2. forehead hairline increases；3. continuous alopecia in 3 months is at daily 100 or more, hair is tapered. All 2 met in above-mentioned 3, that is, be diagnosed as alopecia seborrheica.Exclusion criteria 1. endocrine alopecia, such as thyroid function Low or hyperfunction, parathyroid gland or primary pituitary hypofunction, hypogonadism, diabetes etc.；2. alopecia medicamentosa, symptomatic Alopecia, women postpartum alopecia；3. lactation or pregnancy women；4. used glucocorticoid or immunosupress in first 1 month for the treatment of Agent takes used Chinese medicine orally in 1 week or inhibits the patients such as the drug of sex hormone.Patient is randomly divided into 1 group, 2 groups, 3 groups of experiment； Each group, in general information such as gender, age, the courses of disease, is handled through statistical analysis, and indifference is anisotropic, is comparable（P ＞ 0.05）.

1.2 alopecia areata

172 patients from Dermatology Outpatient Department are chosen, alopecia areata diagnostic criteria is met.Wherein, man 90, female 82, age 32~51 years old, the course of disease was in 0.9~1.8 year, at skin lesion 1~5, alopecia area 0.5cm × 1.0cm~5.0cm × 7.0cm.Exclude alopecia syphilitica, androgenetic alopecia etc..Without hypertension, diabetes aldosterone disease, hypopotassaemia, hepatic and renal function It is incomplete, pregnant woman, nursing period patient.Patient is divided into 1 group, 2 groups, 3 groups of experiment；Each group in gender, age, course of disease etc. one As data, no significant difference is comparable（P ＞ 0.05）.

2. therapy

2.1 alopecia seborrheica

The patient of alopecia seborrheica puts experiment 1 group, 2 groups, 3 groups of drugs outside treatment group on the skin, smears daily 3 times, each primary in the morning, afternoon and evening, Apply ointment 5ml every time, and each group trial drug is made into concentration 0.6g crude drugs/ml, continuously applies ointment 50 days；Diet is with light during treatment Based on, avoid high heat or fried food.Adhere to scalp massage.

2.2 alopecia areata

Patients with alopecia areata puts experiment 1 group, 2 groups, 3 groups of drugs outside treatment group on the skin, smears daily 3 times, each primary in the morning, afternoon and evening, applies ointment every time 5ml, each group trial drug are made into concentration 0.6g crude drugs/ml, continuously apply ointment 50 days；Observe its clinical treatment situation.

3 criterions of therapeutical effect and treatment results

3.1 alopecia seborrheica criterions of therapeutical effect：

It is effective：The experiment of comb hair (advises patient to wash hair weekly 2 times, the 2nd after hair washing day combs hair with wooden comb 10 times from the front to the back) Epilation radical reduces 50% or more before relatively treating, and sebum secretion, dandruff significantly reduce, and itching of the scalp is substantially reduced, alopecia Area has new hair to grow.

Effectively：Epilation radical reduces 20%~50% before relatively treating in comb hair experiment, sebum secretion, dandruff and head Skin itch makes moderate progress.

In vain：Epilation radical is reduced before relatively treating in comb hair experiment is less than 20%, sebum secretion, dandruff and scalp scabies The symptoms such as itch are not improved.

3.2 alopecia areata criterions of therapeutical effect：

Recovery from illness：The all growths of new hair, chroma of hair, thickness and density restore normal；

It is effective：70% or more kainogenesis is long, and hair thickness, color and luster are close to normally.

Effectively：10%~70% kainogenesis is long, depilation phenomenon no longer occurs.

In vain：It has no that growth or hair be not long by 2 course of therapy hairs to fall off instead.

1 each test group of table is treated the effect of alopecia seborrheica and is compared

Group	N	It is effective	Effectively	In vain	Gross efficiency
						Test 1 group	62	37	18	5	91.7%
Test 2 groups	47	28	15	4	91.5%
						Test 3 groups	51	33	12	6	88.2%

By the experimental result of table 1 it is found that after the clinical treatment of 2 courses for the treatment of, it is apparent that sebum secretion, dandruff occur in Most patients It reduces, itching of the scalp is substantially reduced, and the situation of alopecia radical reduction, the state of an illness is improved.Patient, which wipes, tests 1 group, 2 groups, 3 groups Drug total effective rate up to 90% or more, the above clinical efficacy result explanation, Chinese medicine preparation prepared by technical solution of the present invention is being controlled In terms for the treatment of alopecia seborrheica, there is curing protrusion effect, and each test group drug does not occur adverse reaction.

2 each test group of table is treated the effect of alopecia areata and is compared

Group	N	It is effective	Effectively	In vain	Gross efficiency
						Test 1 group	66	41	16	9	86.4%
Test 2 groups	49	28	15	6	87.8%
						Test 3 groups	57	35	16	6	89.5%

By the experimental result of table 2 it is found that 3 groups of patients are after the treatment of 2 courses for the treatment of of drug, Most patients have newborn hair It grows, and thick and black, the case where no epilation, before medication, symptom all improves significantly.The result shows that 1 group of experiment, 2 groups, 3 groups of total effective rates be respectively 86.4%, 87.8%, 89.5%, the above clinical efficacy is as a result, it was confirmed that technical solution of the present invention The Chinese medicine preparation of preparation has apparent therapeutic effect in terms for the treatment of alopecia areata, and over the course for the treatment of, does not find each examination Test the adverse reaction of group drug.

The above is only the application implementation mode of the present invention, it is noted that for the ordinary skill people of the art For member, without departing from the technical principles of the invention, several improvements and modifications can also be made, these improvements and modifications Also it should be regarded as protection scope of the present invention.

Claims

1. it is a kind of treat alopecia areata, alopecia seborrheica antibacterial aqua, it is characterised in that：The weight proportion of each material composition is as follows：

2. it is a kind of treat alopecia areata, alopecia seborrheica antibacterial aqua, which is characterized in that the weight proportion of each material composition is as follows：

2-3 parts of cacumen biotae, 3-4 parts of the fleece-flower root, 2-3 parts of the rhizome of davallia, 2-3 parts of safflower, 2-4 parts of frutus cnidii, 5-7 parts of dittany bark, river 4-6 parts of rhizome of chuanxiong, 3-4 parts of Radix Angelicae Sinensis, 20-30 parts of castor oil, 2-3 parts of acetic acid chlorhexidine.

3. it is a kind of treat alopecia areata, alopecia seborrheica antibacterial aqua, it is characterised in that：The weight proportion of each material composition is as follows：

3-5 parts of cacumen biotae, 4-5 parts of the fleece-flower root, 3-4 parts of the rhizome of davallia, 1-2 parts of safflower, 4-6 parts of frutus cnidii, 4-6 parts of dittany bark, river 2-4 parts of rhizome of chuanxiong, 1-3 parts of Radix Angelicae Sinensis, 30-40 parts of castor oil, 3-4 parts of acetic acid chlorhexidine.

4. it is a kind of treat alopecia areata, alopecia seborrheica antibacterial aqua, it is characterised in that：The weight proportion of each material composition is as follows：

5. it is a kind of treat alopecia areata, alopecia seborrheica antibacterial aqua, it is characterised in that：Based on modern Chinese medicine and doctor trained in Western medicine to alopecia areata, The pathogenetic understanding of alopecia seborrheica and principle of reatment, selected Chinese and western medical raw material, are formulated using unique formula, are controlled When treatment, external application can once a day or twice cure for 1~2 month.

6. it is a kind of treat alopecia areata, alopecia seborrheica antibacterial aqua preparation method, include the following steps：