CN102908602B - Medicinal composition with acne-removing effect and preparation method thereof - Google Patents
Medicinal composition with acne-removing effect and preparation method thereof Download PDFInfo
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- CN102908602B CN102908602B CN201210439331.6A CN201210439331A CN102908602B CN 102908602 B CN102908602 B CN 102908602B CN 201210439331 A CN201210439331 A CN 201210439331A CN 102908602 B CN102908602 B CN 102908602B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 230000000694 effects Effects 0.000 title abstract description 10
- 241001116389 Aloe Species 0.000 claims abstract description 7
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 7
- 239000003814 drug Substances 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 17
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000003643 water by type Substances 0.000 claims description 6
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 3
- 235000011572 Pyrus ussuriensis Nutrition 0.000 claims description 3
- 244000173166 Pyrus ussuriensis Species 0.000 claims description 3
- 235000021355 Stearic acid Nutrition 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims description 3
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- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 238000002481 ethanol extraction Methods 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims description 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 3
- 229960003415 propylparaben Drugs 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 239000008117 stearic acid Substances 0.000 claims description 3
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 2
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- 230000002087 whitening effect Effects 0.000 abstract description 3
- 208000020154 Acnes Diseases 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 244000286838 Eclipta prostrata Species 0.000 abstract 1
- 235000017276 Salvia Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 240000004534 Scutellaria baicalensis Species 0.000 abstract 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract 1
- 244000273928 Zingiber officinale Species 0.000 abstract 1
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- 230000000844 anti-bacterial effect Effects 0.000 description 3
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- 231100000957 no side effect Toxicity 0.000 description 3
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- 206010020649 Hyperkeratosis Diseases 0.000 description 2
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- 239000003098 androgen Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
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- 201000004700 rosacea Diseases 0.000 description 1
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- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicinal composition with an acne-removing effect and a preparation method thereof. The medicinal composition comprises the following Chinese medicinal components in parts by weight: 25-35 parts of red-rooted salvia root, 15-25 parts of yerbadetajo herb, 10-20 parts of dahurian angelica root, 10-20 parts of dried ginger, 5-15 parts of baikal skullcap root and 5-15 parts of aloe. The invention provides a medicinal composition with an acne-removing effect and a preparation method thereof. The medicinal composition is prepared in combination with a modern bioengineering technology, can be used for completely curing acnes without causing relapse, has a good decolorizing repair function, is free from side effects, and has the effects of protecting skin, whitening skin, thinning skin and tenderizing skin.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition with acne-removing and preparation method thereof, belong to cosmetic field.
Background technology
Acne, be again acne, is commonly called as comedo, is the chronic inflammatory pathological changes of a kind of hair follicle sebaceous gland unit, take acne, pimple, pustule, tuberosity, cyst and cicatrix as feature.Its cause of disease and androgen, smegma increase, the hyperkeratosis of pilosebaceous unit pipe, and in glandular tube, propionibacterium acnes moves life, inflammatory mediator and inflammation-related.The traditional Chinese medical science is called again " rosacea caused by lung-wind ", " whelk " etc.
Hebetic skin surface lipide component changes to some extent, and androgen increases, and causes sebum hair follicle conduit hyperkeratosis, and the epithelial cell come off on follicular wall mixes with sebum, and thromboembolism, in follicular orifice, forms acne.Be subject to again the effects such as bacterium acidi propionici (corynebacterium acnes), add that antibacterial infects, cause inflammation, produce abscess, extremely painful after trouble.
The medicine that removes the speckle acne removing of seeing in the market is a lot, what have is for oral administration, the outer painting had, Western medicine is on the high side, side effect is often arranged after use, the drug effect of common Chinese is slower again, treat not thorough, tend to scar, bring permanent spirit and the misery of the human body to the patient, the more important thing is that common anti-acne medicine is to allergic skin inapplicable, some nonallergic skin later also can be irritated in medication, make pore expansion etc., in order to remove the vexation of comedo to countless youth of both sexes, relevant scientific and technical personnel are making great efforts to explore, study new problem.
Summary of the invention
Purpose: for solving the deficiencies in the prior art, the invention provides a kind of pharmaceutical composition with acne-removing and preparation method thereof, determined curative effect, have no side effect, be difficult for recurrence.Massive planting thing elite, can be antibacterial rapidly, and detoxification sore treatment, can improve color of the leather, recovers skin, protection skin.
Technical scheme: for solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of pharmaceutical composition with acne-removing, comprise Chinese medicinal components, described Chinese medicinal components and parts by weight are: Radix Salviae Miltiorrhizae 25-35 part, Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) 15-25 part, Radix Angelicae Dahuricae 10-20 part, Rhizoma Zingiberis 10-20 part, Radix Scutellariae 5-15 part, Aloe 5-15 part.
The preparation method of described Chinese medicinal components is as follows: by Radix Salviae Miltiorrhizae, Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae), the Radix Angelicae Dahuricae, Rhizoma Zingiberis, Radix Scutellariae, the pure Chinese crude drug of Aloe, according to above-mentioned formula proportion, fully mix, then under the high temperature of 50-70 ℃, dry, make it naturally cool to room temperature, and use equipment that mixture is crushed to the 60-80 order, and become pulverulent mixture, stand-by; Then after dry pulverulent mixture being placed in pot or tank body to 70 parts of alcohol-waters with 5-8 times of volume and soaking 24 hours, then extracted with 70 parts of alcohol-waters, dry must ethanol extraction, be Chinese medicine extract.
Described a kind of pharmaceutical composition with acne-removing, comprise A phase and B phase; Wherein A each component of phase and parts by weight are:: C16-18 alcohol 1-10 part, glyceryl monostearate 1-10 part, stearic acid 1-10 part, fatty acid Pyrusussuriensis smooth (span) 1-10 part, peregal 1-10 part, Chinese medicine extract 5-15 part; B mutually each component and parts by weight is: medicinal glycerin 5-55 part, PEG-400 are that 5-55 part, methyl hydroxybenzoate 0.2-1.0 part, propylparaben 0.2-1.0 part, EDTA are that 0.02-0.2 part, surplus are deionized water, and A phase and B phase weight summation are 100 parts.
Described a kind of preparation method with pharmaceutical composition of acne-removing, comprise the steps: that (1) is according to described formula proportion, by A mutually all raw materials be mixed to get mixture solution A, and be heated to 60-90 ℃, homogenizing 25-45 minute; (2) by B mutually all raw materials be mixed to get mixture solution B, and be heated to 60-90 ℃, homogenizing 25-45 minute; (3) first add mixture solution A in mixing kettle, be heated to 60-90 ℃, under agitation add mixture solution B, continue homogenizing and stir 10-30 minute, be cooled to below 38 ℃, stop stirring, discharging, packing, obtain the anti-acne finished product.
Beneficial effect: a kind of pharmaceutical composition with acne-removing provided by the invention and preparation method thereof; in conjunction with modern biotechnology; make and can thoroughly eradicate acne; after not multiple after removing; good decolouring repair is arranged; have no side effect, there is protection skin, the effect that make skin whitening, attenuate, tenderizes.
The specific embodiment
Below in conjunction with example, the present invention is done and illustrates:
Embodiment 1: a kind of pharmaceutical composition with acne-removing, comprise Chinese medicinal components, and described Chinese medicinal components and parts by weight are: 35 parts of Radix Salviae Miltiorrhizaes, 25 parts of Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae), 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Rhizoma Zingiberiss, 10 parts of Radix Scutellariaes, 10 parts of Aloes.
The preparation method of Chinese medicinal components is as follows: by Radix Salviae Miltiorrhizae, Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae), the Radix Angelicae Dahuricae, Rhizoma Zingiberis, Radix Scutellariae, the pure Chinese crude drug of Aloe, according to above-mentioned formula proportion, fully mix, then under the high temperature of 50-70 ℃, dry, make it naturally cool to room temperature, and use equipment that mixture is crushed to the 60-80 order, and become pulverulent mixture, stand-by; Then after dry pulverulent mixture being placed in pot or tank body to 70 parts of alcohol-waters with 5-8 times of volume and soaking 24 hours, then extracted with 70 parts of alcohol-waters, dry must ethanol extraction, obtain Chinese medicine extract 1.
A kind of pharmaceutical composition with acne-removing, comprise A phase and B phase; Wherein A each component of phase and parts by weight are: 5 parts of C16-18 alcohol, 5 parts of glyceryl monostearates, 5 parts of stearic acid, smooth 5 parts of fatty acid Pyrusussuriensis, 5 parts of peregals, Chinese medicine extract 1 are 10 parts; B mutually each component and parts by weight is: 20 parts of medicinal glycerins, PEG-400 are that 20 parts, 0.8 part of methyl hydroxybenzoate, 0.8 part of propylparaben, EDTA are 23.3 parts of 0.1 parts, deionized water.
Described a kind of preparation method with pharmaceutical composition of acne-removing, comprise the steps: that (1) is according to described formula proportion, by A mutually all raw materials be mixed to get mixture solution A, and be heated to 60-90 ℃, homogenizing 25-45 minute; (2) by B mutually all raw materials be mixed to get mixture solution B, and be heated to 60-90 ℃, homogenizing 25-45 minute; (3) first add mixture solution A in mixing kettle, be heated to 60-90 ℃, under agitation add mixture solution B, continue homogenizing and stir 10-30 minute, be cooled to below 38 ℃, stop stirring, discharging, packing, obtain the anti-acne finished product.
Embodiment 2 to embodiment 4:
Preparation method by Chinese medicinal components in the Chinese medicinal components content repeated experiments embodiment 1 of appointment in following table 1, obtain respectively the Chinese medicine extract 1 of different component content to Chinese medicine extract 4.
Table 1
| Chinese medicinal components | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| Radix Salviae Miltiorrhizae (part) | 35 | 25 | 30 | 25 |
| Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) (part) | 25 | 15 | 20 | 25 |
| The Radix Angelicae Dahuricae (part) | 10 | 10 | 20 | 15 |
| Rhizoma Zingiberis (part) | 10 | 20 | 10 | 15 |
| Radix Scutellariae (part) | 10 | 15 | 15 | 5 |
| Aloe (part) | 10 | 15 | 5 | 15 |
| Obtain | Chinese medicine extract 1 | Chinese medicine extract 2 | Chinese medicine extract 3 | Chinese medicine extract 4 |
There is the preparation method of the pharmaceutical composition of acne-removing in each constituent content repeated experiments embodiment 1 by appointment in following table 2, obtain respectively the product 1 of different component content to product 4.
Because this has in the pharmaceutical composition of acne-removing, except the Chinese medicine extraction beyond the region of objective existence, it is little on the impact of product efficacy that other are the substrate accessory formula, therefore, at this, the concrete proportion of composing of other substrate adjuvant components gets final product in right amount, as those skilled in the art, the proportioning amount of selecting of adjuvant can be grasped, and gives an example no longer one by one.
By a kind of pharmaceutical composition with acne-removing of making in embodiment 1 to embodiment 4 and preparation method thereof product 1 to product 4, with existing product for resolving poxes carry out the clinical experiment contrast, experimental result is as shown in table 3:
Table 3
| ? | Existing product | Product 1 | Product 2 | Product 3 | Product 4 |
| The pox that disappears natural law (my god) | 90 | 28 | 20 | 30 | 25 |
| Cure rate (%) | 10 | 97 | 98 | 97.5 | 97.5 |
| Whether leave vestige | Be | No | No | No | No |
| Recurrence probability (%) | 50 | 8 | 6 | 9 | 10 |
To 120 people's clinical trials, average cure rate is 97.5%, wherein:
21 people's recoveries from illness of 18 years old; 24 people's recoveries from illness in 25 people of 19 years old, wherein 1 Genus Homo anaphylaxis is failed to respond to any medical treatment.; 12 people's recoveries from illness of 20 years old; 11 people's recoveries from illness of 21 years old; 8 people's recoveries from illness of 22 years old; 5 people's recoveries from illness of 23 years old; 4 people's recoveries from illness of 24 years old; 14 people's recoveries from illness in 15 people of 25 years old, wherein 1 is invalid because taking contraceptive; 18 people's recoveries from illness in 19 people of 26 years old, wherein 1 Genus Homo anaphylaxis is failed to respond to any medical treatment.
Usage and consumption: be applied in affected part, application area be take and is greater than ill area as good, for not affecting patient's work or study, can utilize treated the length of one's sleep in the evening, and the rear warm hot water of getting up morning is cleaned and got final product.
The course for the treatment of: must not be less than 96 hours, treatment time puts in place, after healing, can not rebound.
Can find out; a kind of pharmaceutical composition with acne-removing that the invention provides and prepare and preparation method thereof; skin is had to clean skin, anti-acne, repair; can kill fast epidermis antibacterial and hair follicle root bacillus, can thoroughly eradicate acne, after not answering after removing; good decolouring repair is arranged; have no side effect, there is protection skin, the effect that make skin whitening, attenuate, tenderizes.
Below with preferred embodiment, disclose the present invention, so it is not intended to limiting the invention, and all employings are equal to replaces or technical scheme that the equivalent transformation mode obtains, within all dropping on protection scope of the present invention.
Claims (3)
1. the pharmaceutical composition with acne-removing, comprise Chinese medicinal components, the preparation method of described Chinese medicinal components is as follows: Radix Salviae Miltiorrhizae 25-35 part, Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) 15-25 part, Radix Angelicae Dahuricae 10-20 part, Rhizoma Zingiberis 10-20 part, Radix Scutellariae 5-15 part, Aloe 5-15 part Chinese crude drug, proportionally fully mix, then dry under the high temperature of 50-70 ℃, make it naturally cool to room temperature, and use equipment that mixture is crushed to the 60-80 order, become pulverulent mixture, stand-by; Then after dry pulverulent mixture being placed in pot or tank body to 70 parts of alcohol-waters with 5-8 times of volume and soaking 24 hours, then extracted with 70 parts of alcohol-waters, dry must ethanol extraction, obtain.
2. a kind of pharmaceutical composition with acne-removing according to claim 1, is characterized in that; Comprise A phase and B phase; Wherein A each component of phase and parts by weight are: C16-18 alcohol 1-10 part, glyceryl monostearate 1-10 part, stearic acid 1-10 part, the smooth 1-10 part of fatty acid Pyrusussuriensis, peregal 1-10 part, described Chinese medicinal components 5-15 part; B mutually each component and parts by weight is: medicinal glycerin 5-55 part, PEG-400 are that 5-55 part, methyl hydroxybenzoate 0.2-1.0 part, propylparaben 0.2-1.0 part, EDTA are that 0.02-0.2 part, surplus are deionized water, and A phase and B phase weight summation are 100 parts.
3. a kind of preparation method with pharmaceutical composition of acne-removing according to claim 2, comprise the steps: (1) proportionally, by A mutually all raw materials be mixed to get mixture solution A, and be heated to 60-90 ℃, homogenizing 25-45 minute; (2) by B mutually all raw materials be mixed to get mixture solution B, and be heated to 60-90 ℃, homogenizing 25-45 minute; (3) first add mixture solution A in mixing kettle, be heated to 60-90 ℃, under agitation add mixture solution B, continue homogenizing and stir 10-30 minute, be cooled to below 38 ℃, stop stirring, discharging, packing, obtain.
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| CN201210439331.6A CN102908602B (en) | 2012-11-07 | 2012-11-07 | Medicinal composition with acne-removing effect and preparation method thereof |
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| CN201210439331.6A CN102908602B (en) | 2012-11-07 | 2012-11-07 | Medicinal composition with acne-removing effect and preparation method thereof |
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| CN1342474A (en) * | 2000-09-08 | 2002-04-03 | 俞宝明 | Functional additive for cosmetics |
| CN1626170A (en) * | 2003-12-08 | 2005-06-15 | 赵传水 | Formula of Chinese traditional medicine possessing effects of removing spots and pocks as well as preparation method |
| CN1236801C (en) * | 2004-03-05 | 2006-01-18 | 北京建昊嘉信科技有限公司 | Licorice root compound for treating acne |
| CN101897865A (en) * | 2009-05-27 | 2010-12-01 | 北京因科瑞斯医药科技有限公司 | Medicinal composition with function of removing acne and preparation method thereof |
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