CN1244353C - Medicine for curing acne and its preparation method - Google Patents
Medicine for curing acne and its preparation method Download PDFInfo
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- CN1244353C CN1244353C CN 02104046 CN02104046A CN1244353C CN 1244353 C CN1244353 C CN 1244353C CN 02104046 CN02104046 CN 02104046 CN 02104046 A CN02104046 A CN 02104046A CN 1244353 C CN1244353 C CN 1244353C
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Abstract
The present invention relates to a medicine for treating acne and a preparation method thereof, which aims at solving the problems of poor curative effect and high side effect of the existing similar medicines. The medicine is prepared from raw materials in the following weight proportion: 25 to 50 portions of oldenlandia, 8 to 20 portions of honeysuckle flower, 8 to 20 portions of forsythia fruit, 8 to 20 portions of rehmannia root, 8 to 20 portions of tree peony bark, 8 to 25 portions of red peony root, 8 to 20 portions of scutellaria, 8 to 20 portions of mulberry bark, 8 to 30 portions of gypsum, 8 to 25 portions of red sage root, 8 to 20 portions of Chinese honeylocust spine, 8 to 20 portions of ledebouriella root and 4 to 10 portions of licorice root. Thus, the medicine for treating acne has the advantages of high effective ingredient content, small dosage, obvious curative effect, no toxic or side effect, high safety, high efficiency and convenient use.
Description
Technical field:
The present invention relates to a kind of medicine for the treatment of acne, specifically is the Chinese patent medicine of primary raw material preparation with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Technical background:
Acne is the chronic inflammatory disease dermatoses of a kind of hair follicle and sebaceous gland, claims acne, pimples again.Microorganism is the main cause that acne takes place in endocrine regulation, seborrhea and the hair follicle.Acne is a dermatology common disease, and according to Andrew's dermatological statistics, acne is in various degree suffered from by 90% adolescence.
To the treatment of primary disease, following clinical difficult problem puzzlement is arranged at present:
1, acne is a kind of frequently-occurring disease, commonly encountered diseases, the more and mutual intersection of the cause of disease, thereby the clinical recurrence rate is high.Main cause just is that (1), patient replace medicine with cosmetics; (2) most drug is cured the symptoms, not the disease; (3), most drug designs at a kind of cause of disease.Temporarily improve symptom, very fast recurrence again.
2, hormone medicine is affirmed the cyst type acne curative effect, but the abuse side effect is very big, unsuitable conventional the application.
3, the Chinese patent medicine of present less treatment primary disease, only several not fairly obvious as effects such as heat clearing away skin sore ball, little leaf deervetch herb acne removing balls, can not satisfy the clinical treatment needs.
Summary of the invention:
The medicine of the treatment acne that the object of the present invention is to provide a kind of good effect of making by pure Chinese medicine and have no side effect.
Another object of the present invention provides the preparation method of this Retinoids, Retin-A, Renova, Accutane.
Solution of the present invention is based on motherland's medical science to pathogenetic understanding of acne disease and Therapeutic Principle, with reference to modern medicinal agents, pharmaceutical research achievement and form.
The composition principle of medicine of the present invention is: in motherland's medical science, acne is had comparatively maturation and scientific understanding, formed the theoretical system of complete uniqueness.Medicine of the present invention is prescription according to this, reuses Herba Hedyotidis Diffusae in (1) square granule, with heat clearing away repercussive, eliminating carbuncle detoxifcation.Pharmacological research shows that this medical instrument has the effect of anti-inflammation.Flos Lonicerae, Fructus Forsythiae heat-clearing and toxic substances removing help the power of prodrug, are monarch drug altogether.Minister is with Radix Rehmanniae, and interior special removing heat from blood YIN nourishing is moistened skin Rong Ze outward; Cortex Moutan is specially gone into blood system, can rush down the blood fire second of the three ten-day periods of the hot season, the heap soil or fertilizer over and around the roots blood stasis that can dispel the heat again, and three medicines share, clearing away heat from YING and blood systems, the power of promoting tissue regeneration by removing blood stasis is strong especially.The face nose belongs to lung, is again that positive bright stomach is through the area-covered.So purge heat with the Radix Scutellariae bitter cold.Straight folding fire originally; Cortex Mori is apt to away edema caused by disorder of QI in the lung, and clear purte the white, Radix Scutellariae get pathogenic heat in the then special eliminating the pathogens from the lung of Cortex Mori, more use Gypsum Fibrosum, sweet trembling with fear into the lung stomach, the heat of the skin of passing through inside, the fire of interior eliminating the pathogens from the lung stomach.Assistant is with Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, blood circulation promoting and blood stasis dispelling, and the removing heat from blood eliminating carbuncle is to help Radix Rehmanniae, the diathermanous power of Cortex Moutan; Spina Gleditsiae is searched wind and is drawn out pus by applying a plaster to the affected part, detumescence and apocenosis, carbuncle is the one-tenth person not, can draw dissipating, will the person of breaking, can draw to lift one's head, the person that burst can draw to go pus, be the pioneer who convinces by patient analysis.Radix Saposhnikoviae is hot diffusing up, drives the ailment said due to cold or exposure of diseases caused by exogenous pathogenic factor, and draws the through sick institute of all medicines; Radix Glycyrrhizae heat-clearing and toxic substances removing, but also coordinating the actions of various ingredients in a prescription.Full side plays heat-clearing and toxic substances removing, the effect of cool the blood dissipate blood stasis altogether.Modern pharmacology experiment showed, that this type of Chinese medicine has the effect of inhibiting bacteria and diminishing inflammation.Have wider antimicrobial spectrum as Radix Scutellariae, Radix Rehmanniae, Radix Paeoniae Rubra, Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae also have stronger bacteriostasis.
The medicine that the present invention treats acne is the medicament of being made by the following weight proportion raw material
8～20 parts of 8～20 parts of Fructus Forsythiaes of 25～50 portions of Flos Loniceraes of Herba Hedyotidis Diffusae
8～25 parts of 8～20 parts of Radix Paeoniae Rubra of 8～20 parts of Cortex Moutans of Radix Rehmanniae
8～30 parts in 8～20 parts of Gypsum Fibrosum of 8～20 parts of Cortex Mori of Radix Scutellariae
8～20 parts of 8～20 parts of Radix Saposhnikoviaes of 8～25 parts of Spina Gleditsiaes of Radix Salviae Miltiorrhizae
4～10 parts in Radix Glycyrrhizae
The preferred weight proportioning of above-mentioned raw materials medicine is:
8～15 parts of 8～15 parts of Fructus Forsythiaes of 25～40 portions of Flos Loniceraes of Herba Hedyotidis Diffusae
8～20 parts of 8～15 parts of Radix Paeoniae Rubra of 8～15 parts of Cortex Moutans of Radix Rehmanniae
8～25 parts in 8～15 parts of Gypsum Fibrosum of 8～15 parts of Cortex Mori of Radix Scutellariae
8～15 parts of 8～15 parts of Radix Saposhnikoviaes of 8～20 parts of Spina Gleditsiaes of Radix Salviae Miltiorrhizae
4～8 parts in Radix Glycyrrhizae
The optimum weight proportioning of above-mentioned raw materials medicine is:
10 parts of 10 parts of Fructus Forsythiaes of 37.5 portions of Flos Loniceraes of Herba Hedyotidis Diffusae
12.5 parts of 10 parts of Radix Paeoniae Rubra of 10 parts of Cortex Moutans of Radix Rehmanniae
16.7 parts in 10 parts of Gypsum Fibrosum of 10 parts of Cortex Mori of Radix Scutellariae
10 parts of 10 parts of Radix Saposhnikoviaes of 12.5 parts of Spina Gleditsiaes of Radix Salviae Miltiorrhizae
5 parts in Radix Glycyrrhizae
Said medicament is the dosage form on any pharmaceutics.
As optimization, said dosage form is a granule.
The preparation method that the present invention treats the medicine of acne be get Radix Salviae Miltiorrhizae according to the above ratio, Herba Hedyotidis Diffusae is used the alcoholic solution reflux, extract,, discards residue, reclaims ethanol, extracting solution is standby; Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae medicinal residues and all the other Cortex Mori etc. ten decoct with water simply, discard residue, and aqueous solution and said extracted liquid merge, and concentrate the back residue and add suitable adjuvant, make granule behind the mixing.
The concrete production method of medicine of the present invention is:
1,13 flavors are got Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae alcoholic solution reflux, extract, in described ratio in the prescription, discard residue, reclaim ethanol, and extracting solution is standby;
2, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae medicinal residues and all the other Cortex Mori etc. ten decoct with water simply, discard residue, and aqueous solution and said extracted liquid merge the back residue and adds suitable adjuvant, make granule behind the mixing.
An important feature of medicine of the present invention is
1, presses the Chinese medical theory prescription, and in conjunction with the pure Chinese medicine that the modern scientific research achievement is made, have short treating period clinically, the characteristics of instant effect.At commonly encountered diseases, frequently-occurring disease, a sick medicine, outstanding Chinese medicine characteristic.
2, the prescription Chinese crude drug through science extract, purification, improve active constituent content, reduce dose, confirm evident in efficacyly through pharmacodynamics, toxicological experiment, do not see toxicity.Reached purpose safe, effective, taking convenience.
3, each step of pharmaceutical preparation of the present invention all has preparation laboratory data and the support of pharmacodynamics preference data, and has formulated a content of effective testing index, thereby guarantees product quality.
4, treat the medicine and the medical procedure of primary disease at present, can not satisfy the clinical treatment needs.Medicine of the present invention provides a kind of new efficient medicine, increases a kind of powerful mean for clinical with the card medication.
Another important feature of medicine of the present invention is
1, contains large number of biological alkali in the medicament, comprise berberine, coptisine, graveoline, peonine etc., have broad-spectrum antiseptic, antivirus action and antiinflammatory, analgesic activity.
2, also contain a large amount of glycoside compositions in the medicament, comprise xylostein, iridoid glycoside, peoniflorin, glycyrrhizin and triterpene saponin and soap unit oleanolic acid, ursolic acid, various pathogens, virus there is inhibitory action, significantly antiinflammatory action and 17-hydroxy-11-dehydrocorticosterone sample immunosuppressive action strengthen body immunity.
3, also contain a large amount of flavones ingredients in the medicament, total content reaches 1.7～2.6%, comprises baicalin, Morusin, TANSHINONES etc., the peripheral circulation of improvement obstacle is arranged, anticoagulant and fibrinolysis activity.
The clinical use result of medicine of the present invention shows that following advantage is arranged:
1, mainly to select natural plant for use be raw material in the present invention, and each component all meets Pharmacopoeia of the People's Republic of China regulation, press the comprehensive function of Chinese medical theory prescription and treat acne.
2, medicine of the present invention through extract, purification, active constituent content height, dose are little, and the strict quality index is arranged, and reach safe and effective, and be quality controllable, the taking convenience requirement.Meet national medical rules.
3, medicine of the present invention provides a kind of new treatment means for acne treatment, avoids the side effect of Western medicine and hormone.And importantly avoid the recurrence of disease effectively.
It has the comprehensive acne symptom that improves, and endocrine regulation reduces testosterone levels simultaneously, improves body immunity.Be aided with antiinflammatory, analgesic pharmacological action, comprehensive, many-side is thoroughly treated acne at the cause of disease.
The adapted medicine for external use can be realized treating both the exterior and interior preferably, must can repercussive blood with in a moment, the heat-transformation poison is gone back skin with clean U.S. with invisible, the beautiful appearance in multiple youth.
For showing the therapeutic effect of medicine of the present invention, medicine of the present invention is through the clinical observation of 60 routine systems, according to " new Chinese medicine clinical research guideline " version in 1997 draft in, the patients with acne made a definite diagnosis of Western medicine diagnose, dialectical standard, include the experiment case in.
Differential diagnosis in tcm standard (syndrome of blood stasis due to lung heat)
Acne primary symptom: pimple or show effect repeatedly pustule, tuberosity, cyst.Inferior card: (1) Blushing; (2) skin greasing; (3) constipation; (4) red tongue, yellow and thin fur; (5) wiry and frequent pulse.Main symptom indispensability is wherein doublely seen three of time cards, and is promptly diagnosable.
Instructions of taking: medicine of the present invention (trial-production of Liaoyang City's natural drug institute), each 1 bag of granule, every day 3 times, warm boiled water.Serve on for two weeks.The ointment of applying on the same day with another part of the inventor behind the warm water cleaning skin is applied to the affected part in right amount, (name of this ointment application for a patent for invention is called the ointment for the treatment of acne).
The course of treatment: two weeks were a course of treatment, used two courses of treatment.Follow up a case by regular visits to two courses of treatment after the drug withdrawal.
Result of the test
(1), efficacy assessment standard and foundation: the efficacy assessment standard in the clinical research guideline of acne " new Chinese medicine treatment " issued with reference to Ministry of Health of the People's Republic of China and drafting.
The symptom integral method
Acne: do not have 0 fen; Slightly (blackhead is distributed to pilosity, and the inflammatory pimple is distributed.) 2 minutes: (slight+shallow at the property pustule, inflammatory pimple number increases moderate, is confined to face.) 4 minutes: severe (moderate+deeply at property inflammatory pimple, tuberosity, generation and face, cervical region and chest and back) 6 minutes.
Blushing: normal 0 minute; Conscious face heat, constant 1 minute of complexion; Flushed face, the heat of laying one's hand on very 2 minutes; Face is red to expand, the bright hands of laying one's hand on 3 minutes.
Skin greasing: normal 0 minute; Oily skin 1 minute; Sebum secretion is vigorous, face bellding light 2 minutes; Sebum secretion is extremely vigorous, skin greasing 3 minutes;
Constipation: defecated normal 0 minute; Be hard and dry 1 fen; Constipation due to dry stool was difficult to resolve 2 fens; Constipation due to dry stool needs just can solve 3 fens with medicine.
Tongue fur: normal 0 minute; Body of the tongue is red partially, few Tianjin of yellow and thin fur 1 minute; The few tongue of red tongue 2 minutes; Red and uncoated tongue 3 minutes.
Wiry and frequent pulse: normal 0 minute; Slightly several 1 minute; Several 2 minutes; Stringy and rapid pulse 3 minutes.
Efficacy assessment standard
Recovery from illness: treatment back face is clean, and skin lesion disappears, and only leaves pigmentation and cicatrix, and other symptoms disappear substantially, and drug withdrawal is not recurrence after 15 days, and integrated value is below 3 minutes.
Produce effects: treatment back skin lesion has reduced more than 1/2 before than treatment, other transference cure or alleviate, and end recurrence after 15 days after the drug withdrawal, integrated value has reduced more than 2/3 before than treatment.
Effectively: treatment back acne is improved than treatment is preceding, and also than alleviating before the treatment, drug withdrawal is not recurrence after 15 days for other symptoms, and integrated value has reduced more than 1/3 before treating.
Invalid: treatment back skin lesion does not have and improves or increase the weight of, integrated value than treatment before no change or than reducing less than 1/3 before the treatment.
Efficacy analysis: the detailed results of this clinical observation, see the following table general curative effect for details
| Group | n | Recovery from illness | Produce effects | Effectively | Invalid | |||
| Observation group | 60 examples | 38 examples (63.3%) | 11 examples (18.3%) | 6 examples (10.0%) | 5 examples (8.3%) | |||
| The curative effect of state of an illness integration relatively before and after the treatment | ||||||||
| Group | n | Before the treatment (x ± s) | The treatment back (x ± s) | |||||
| Observation group | 60 examples | 1231±4.04 | 3.30±3.44 ** | |||||
Annotate: with relatively use before the treatment
*Expression p＜0.01.
As can be seen from the above table: Drug therapy acne of the present invention, the curative effect of state of an illness integration relatively has utmost point significant difference, p＜0.01 before and after the treatment.
The curative effect that symptom and sign changes before and after the treatment relatively
From following table as can be seen: Drug therapy acne of the present invention, the curative effect that the front and back symptom and sign changes relatively has utmost point significant difference, p＜0.01.
| Sign | n | Before the treatment | After the treatment | u | p |
| +++ +++ + - | +++ ++ + - | ||||
| Acne flushed face skin greasing constipation tongue fur pulse condition | 60 examples, 60 examples, 60 examples, 60 examples, 60 examples, 60 examples | 10 42 8 0 4 8 32 8 6 18 34 2 2 26 32 0 0 8 36 16 0 14 46 0 | 0 4 18 38 0 0 24 36 0 0 24 36 0 8 28 24 0 0 4 56 0 2 20 38 | 6.01 4.02 4.87 3.70 2.66 4.68 | ＜0.01 ＜0.01 ＜0.01 ＜0.01 ＜0.01 ＜0.01 |
As can be seen from the above table: Drug therapy acne of the present invention, the curative effect that the symptom body is just changing before and after the treatment relatively has utmost point significant difference, p＜0.01.
1, the comparison of the state of an illness and curative effect
| The state of an illness | n | Recovery from illness | Produce effects | Effectively | Invalid | x 2 | p |
| Heavy in light | 44 examples, 14 examples, 2 examples | 29 9 0 | 7 2 2 | 4 2 0 | 4 1 0 | 3.82 | ＜0.05 |
As can be seen from the above table: Drug therapy acne of the present invention, the state of an illness and curative effect compare before and after the treatment, x
2=3.82, there is significant difference p＜0.05.
The clinical efficacy of medicine of the present invention
Test statistics shows: the clinical efficacy of Drug therapy acne patient 60 examples of the present invention is satisfied, its cure rate reaches 63.3% (38/60), and obvious effective rate reaches 18.3% (11/60), and effective percentage reaches 10.0% (6/60), cure-remarkable-effectiveness rate reaches 81.6%, and total effective rate reaches 91.6%.
The specific embodiment:
Take by weighing raw material by following proportioning
Herba Hedyotidis Diffusae 25,37.5,50kg Flos Lonicerae 8,10,20kg Fructus Forsythiae 8,10,20kg
Radix Rehmanniae 8,10,20kg Cortex Moutan 8,10,20kg Radix Paeoniae Rubra 8,12.5,25kg
Radix Scutellariae 8,10,20kg Cortex Mori 8,10,20kg Gypsum Fibrosum 8,16.7,30kg
Radix Salviae Miltiorrhizae 8,12.5,25kg Spina Gleditsiae 8,10,20kg Radix Saposhnikoviae 8,10,20kg
Radix Glycyrrhizae 4,5,10kg
13 flavors are got Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae alcoholic solution reflux, extract, in described ratio in will writing out a prescription earlier, discard residue, reclaim ethanol, and extracting solution is standby; Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae medicinal residues and all the other Cortex Mori etc. ten decoct with water simply, discard residue, and aqueous solution and said extracted liquid merge the back residue and adds suitable adjuvant, make granule behind the mixing.
Claims (5)
1, a kind of medicine for the treatment of acne is characterized in that making pharmaceutical composition by the following weight proportion raw material:
8～20 parts of 8～20 parts of Fructus Forsythiaes of 25～50 portions of Flos Loniceraes of Herba Hedyotidis Diffusae
8～25 parts of 8～20 parts of Radix Paeoniae Rubra of 8～20 parts of Cortex Moutans of Radix Rehmanniae
8～30 parts in 8～20 parts of Gypsum Fibrosum of 8～20 parts of Cortex Mori of Radix Scutellariae
8～20 parts of 8～20 parts of Radix Saposhnikoviaes of 8～25 parts of Spina Gleditsiaes of Radix Salviae Miltiorrhizae
4～10 parts in Radix Glycyrrhizae.
2, the medicine of treatment acne according to claim 1, its feature at the weight proportion of described raw material is:
8～15 parts of 8～15 parts of Fructus Forsythiaes of 25～40 portions of Flos Loniceraes of Herba Hedyotidis Diffusae
8～20 parts of 8～15 parts of Radix Paeoniae Rubra of 8～15 parts of Cortex Moutans of Radix Rehmanniae
8～25 parts in 8～15 parts of Gypsum Fibrosum of 8～15 parts of Cortex Mori of Radix Scutellariae
8～15 parts of 8～15 parts of Radix Saposhnikoviaes of 8～20 parts of Spina Gleditsiaes of Radix Salviae Miltiorrhizae
4～8 parts in Radix Glycyrrhizae.
3, the medicine of treatment acne according to claim 2 is characterized in that the weight proportion of described raw material is:
10 parts of 10 parts of Fructus Forsythiaes of 37.5 portions of Flos Loniceraes of Herba Hedyotidis Diffusae
12.5 parts of 10 parts of Radix Paeoniae Rubra of 10 parts of Cortex Moutans of Radix Rehmanniae
16.7 parts in 10 parts of Gypsum Fibrosum of 10 parts of Cortex Mori of Radix Scutellariae
10 parts of 10 parts of Radix Saposhnikoviaes of 12.5 parts of Spina Gleditsiaes of Radix Salviae Miltiorrhizae
5 parts in Radix Glycyrrhizae.
4, according to the medicine of claim 1,2 or 3 described treatment acnes, the dosage form that it is characterized in that this medicine is a granule.
5, a kind of method for preparing the medicine for the treatment of acne is characterized in that selecting raw material in following ratio:
8～20 parts of 8～20 parts of Fructus Forsythiaes of 25～50 portions of Flos Loniceraes of Herba Hedyotidis Diffusae
8～25 parts of 8～20 parts of Radix Paeoniae Rubra of 8～20 parts of Cortex Moutans of Radix Rehmanniae
8～30 parts in 8～20 parts of Gypsum Fibrosum of 8～20 parts of Cortex Mori of Radix Scutellariae
8～20 parts of 8～20 parts of Radix Saposhnikoviaes of 8～25 parts of Spina Gleditsiaes of Radix Salviae Miltiorrhizae
Radix Glycyrrhizae 4-10 part;
Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae are used the alcoholic solution reflux, extract,, discard residue, reclaim ethanol, and extracting solution is standby; Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae medicinal residues and all the other ten decoct with water simply, discard residue, and aqueous solution and said extracted liquid merge, and concentrate the back residue and add suitable adjuvant, make granule behind the mixing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 02104046 CN1244353C (en) | 2002-03-07 | 2002-03-07 | Medicine for curing acne and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02104046 CN1244353C (en) | 2002-03-07 | 2002-03-07 | Medicine for curing acne and its preparation method |
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| CN1443545A CN1443545A (en) | 2003-09-24 |
| CN1244353C true CN1244353C (en) | 2006-03-08 |
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| CN 02104046 Expired - Lifetime CN1244353C (en) | 2002-03-07 | 2002-03-07 | Medicine for curing acne and its preparation method |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100389808C (en) * | 2006-01-10 | 2008-05-28 | 孙小五 | Acne-treating medicinal soap and preparation method thereof |
| CN101601771B (en) * | 2009-07-15 | 2012-01-04 | 陕西雨茂制药有限公司 | Orally-taken Chinese herb preparation for treating acne and preparation method thereof |
| CN102125617B (en) * | 2011-02-25 | 2012-05-30 | 南方医科大学 | Medicine for treating acnevulgaris |
| CN102671081B (en) * | 2012-03-19 | 2015-03-11 | 苏甲臣 | Medicine for treating pimples |
| CN103432536B (en) * | 2013-09-27 | 2014-11-19 | 唐荣兰 | Traditional Chinese medicine composition for treating acne and preparation method thereof |
| CN104606341A (en) * | 2013-11-04 | 2015-05-13 | 沈阳金龙药业有限公司 | Meinuoping particle, and preparation method and detection method thereof |
| CN104055919B (en) * | 2014-07-05 | 2016-05-25 | 葛文涛 | A kind of Chinese medicine composition of Acne treatment |
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2002
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