CN105833187A - Botanical medicine composition with acne removing effect and application - Google Patents
Botanical medicine composition with acne removing effect and application Download PDFInfo
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- CN105833187A CN105833187A CN201610316557.5A CN201610316557A CN105833187A CN 105833187 A CN105833187 A CN 105833187A CN 201610316557 A CN201610316557 A CN 201610316557A CN 105833187 A CN105833187 A CN 105833187A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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Abstract
The invention discloses a botanical medicine composition with an acne removing effect and application. The botanical medicine composition is prepared from radix salviae miltiorrhizae, pomegranate bark, spreading hedyotis herb, rhizoma curcumae and licorice roots. The botanical materials are smashed, screened and mixed, the mixture is added into an extraction solvent and then soaked, room-temperature extraction is carried out with a high-pressure homogenization extraction machine, extraction liquor is subjected to centrifugal separation and then concentrated with a membrane, concentrated liquor is adsorbed with macroporous resin and then eluted repeatedly with ethanol, elution liquor is collected, butanediol is added for dissolution after membrane concentration, filtering is carried out, and the botanical medicine composition is obtained, wherein water or ethanol or an ethanol aqueous solution serves as the extraction solvent. The botanical medicine composition can inhibit secretion of skin grease, effectively inhibit propionibacterium acnes and achieve a good acne removing effect, and can enhance skin immunity, improve skin nature and make skin permeable, clean, smooth and fine when used for a long term.
Description
Technical field
The present invention relates to a kind of autonomic drug composition, this autonomic drug composition has acne-removal function, can apply to anti-acne
In cosmetics, belong to cosmetic field.
Background technology
Whelk, acne, dark sore are medically referred to as acne, are common a kind of sebaceous glands chronic diseases, and its origin cause of formation is
During puberty, internal hormone can grow by stimulating hair, and smegma is vigorous, causes clogging of pores to form acne
Core micro mist stings.Micro mist thorn is invisible, and micro mist thorn grows skin surface needs 7 to 9 months from being formed to
Growth period.Micro mist thorn blocking pore induction inflammation, be papule, useless fellow, tubercle and tumour originate root.Traditional treatment is the most clear
Except the acne on surface, and micro mist thorn stops a period of time and grows, and then defines the situation of acne recurrent exerbation.
Cause the formation mainly following factor of dark sore: (1) internal 3male hormone secretion is too much, and exdermoptosis, sebum divides
Secrete too much drainage difficulty, in being deposited in hair follicle, form fat bolt.Long secondary bacterial infection, causes inflammatory around pilosebaceous follicle anti-
Should, form papule or warts, i.e. dark sore.(2) relevant with heredity, typically there is family history.(3) dysendocrinism, indigestion,
Nervous system disorders.The food and the maror that absorb sugar higher fatty acid, high are its predisposing factors.(4) there is other diseases, cause
Vivotoxin cannot be discharged and be caused small pox, and modal is exactly constipation.(5) the most in time or improperly skin cleaning-nursing.Example
As, excessively cleaning skin causes skin to lose the faintly acid protection of natural sebum film and cause bacterial infection and long acne, the most periodically
Exfoliating causes cuticula to pile up blocked up, blocking pore and cause bacterium to infect.So, anti-acne should from control oily, antibacterial, cleaning,
The aspect comprehensive regulations such as clearing heat and detoxicating, blood stasis-eliminating and stagnation-dissipating.
Chinese herbal medicine cosmetic embodies the thought of differentiation of tcm, with traditional Chinese medical theory for instructing, by suitable medium-height grass
Medicine composition adds among cosmetics, can be from the metabolism of each side regulation bodies such as gas, blood, yin, yang so that Chinese herbal medicine
Cosmetics have the most functional, and with strong points, and cosmetic result is lasting, stable.Resources of Chinese medicinal herb in the Nature, pure temperature
With, have no side effect, more safe and reliable compared to chemical synthesis cosmetics.
Summary of the invention
The first object of the present invention is to provide a kind of autonomic drug composition with acne-removal function, and this autonomic drug composition has
There is acne-removal function.
For realizing this purpose of the present invention, present invention employs following technical scheme: a kind of have planting of acne-removal function
Thing drug composition, it is characterised in that be made up of the autonomic drug component of following percentage by weight: the red sage root 5～50%；Granatum 5～
40%；Oldenlandia diffusa 2～35%；Curcuma zedoary 2～30%；Radix Glycyrrhizae 2～40%.
Preferably, a kind of autonomic drug composition with acne-removal function, it is characterised in that by planting of following percentage by weight
Thing medicine component is made: the red sage root 35%；Granatum 25%；Oldenlandia diffusa 15%；Curcuma zedoary 10%；Radix Glycyrrhizae 15%.
Preferably, a kind of autonomic drug composition with acne-removal function, it is characterised in that by planting of following percentage by weight
Thing medicine component is made: the red sage root 30%；Granatum 20%；Oldenlandia diffusa 20%；Curcuma zedoary 18%；Radix Glycyrrhizae 12%.
Preferably, a kind of autonomic drug composition with acne-removal function, it is characterised in that by planting of following percentage by weight
Thing medicine component is made: the red sage root 40%；Granatum 15%；Oldenlandia diffusa 18%；Curcuma zedoary 12%；Radix Glycyrrhizae 15%.
Preferably, a kind of autonomic drug composition with acne-removal function, it is characterised in that by planting of following percentage by weight
Thing medicine component is made: the red sage root 32%；Granatum 18%；Oldenlandia diffusa 15%；Curcuma zedoary 15%；Radix Glycyrrhizae 20%.
For preparing above-mentioned autonomic drug composition, present invention employs following technical scheme: pulverized by autonomic drug, respectively with 20
～100 mesh sieve screenings, mixing is 5:1 by liquid material mass ratio～20:1 adds Extraction solvent, after soaking 1～5h, 10～
100MPa extracts and carries out normal temperature extraction with high pressure homogenization method machine under pressure, after extract is performing centrifugal separation on, concentrates with film, concentrates
Liquid macroporous resin adsorption, then with volume fraction be 10～95% ethanol repeatedly elute, collect eluent, film is concentrated into extraction
Liquid is 1:0.1～1:5 with the mass ratio of autonomic drug, adds butanediol and dissolves, filter, prepares autonomic drug composition；Extract molten
Agent is water, ethanol or ethanol water.
It is another object of the present invention to be used in acne-eliminating cosmetic above-mentioned autonomic drug composition, make stable in properties, effect
The best acne-eliminating cosmetic.
For realizing this purpose of the present invention, present invention employs following technical scheme: existed by above-mentioned autonomic drug composition
Application in preparation acne-eliminating cosmetic, it is characterised in that containing above-mentioned autonomic drug composition in acne-eliminating cosmetic, its consumption is with matter
Amount mark is calculated as 0.01 ~ 25%, and preferable amount is 0.1 ~ 10%.In cosmetics in addition to containing above-mentioned autonomic drug composition, can
To add the usual composition that applicable acne-eliminating cosmetic uses as suitably desired, such as NMF, emollient, water, emulsifying agent, increasing
Thick dose is waited matrix components.The formulation of acne-eliminating cosmetic is not particularly limited, and can be solution, curry, emulsion, cream shape, spray
Deng.
Beneficial effects of the present invention: the present invention carries out prescription so that traditional Chinese medical science monarch is theoretical for guidance, with the red sage root as monarch drug in a prescription,
Having stasis-dispelling and pain-killing, effect stimulated the menstrual flow of invigorating blood circulation, modern study achievement shows that the active component of the red sage root can effectively suppress male and swash
Element is combined with tissue fluid acceptor, effectively changes the growing environment of whelk, reaches root, be aided with anti-inflammatory, be to treat both principal and secondary aspect of disease
Purpose.Granatum is ministerial drug, has relieving diarrhea with astringents, hemostasis, expelling parasite, containing multiple life in the bright granatum of modern study outcome table
Alkaloids, has a broad-spectrum antibacterial action, and the polyhydric phenols containing the multiple matter that is referred to as mixing, there is good antioxygen
Change, Controlling oil effect, the healing for the surface of a wound has good facilitation.Oldenlandia diffusa and curcuma zedoary are adjutant, wherein long-noded pit viper
Tongue grass has clearing heat and detoxicating, medicinal powder for relieving pain knot, effect of promoting urination and removing dampness；Curcuma zedoary has promoting qi circulation and removing obstruction in the collateral, the broken stasis of blood, the function of pain relieving.Radix Glycyrrhizae
For making medicine, have and middle emergency, moistening lung, clearing heat and detoxicating, effect of coordinating the drug actions of a prescription.By the synergy of above traditional Chinese medicine ingredients,
The purpose of anti-acne anti-acne is reached in terms of controlling oily, antibacterial, clearing heat and detoxicating, blood stasis-eliminating and stagnation-dissipating etc..
Detailed description of the invention
Below by way of specific embodiment come the present invention is further illustrated, but these embodiments simply to illustrate that,
It it not limitation of the present invention.
The preparation of embodiment 1 autonomic drug composition (I)
Take red sage root 35g, granatum 25g, oldenlandia diffusa 15g, curcuma zedoary 10g, Radix Glycyrrhizae 15g, pulverize, respectively with 40 mesh sieve sieves
Point, mixing, it is that to add volume fraction be the ethanol of 50% to 10:1 by liquid material mass ratio, soaks after 3h, under 60MPa extracts pressure
Carrying out normal temperature extraction with high pressure homogenization method machine, after extract is performing centrifugal separation on, concentrate with film, concentrate macroreticular resin is inhaled
Attached, then with volume fraction be 10～95% ethanol repeatedly elute, collect eluent, film is concentrated into the matter of extract and autonomic drug
Amount ratio is 1:1, adds the butanediol with extract uniform quality and dissolves, filter, prepares autonomic drug composition.
The preparation of embodiment 2 autonomic drug composition (II)
Take red sage root 30g, granatum 20g, oldenlandia diffusa 20g, curcuma zedoary 18g, Radix Glycyrrhizae 12g, pulverize, respectively with 60 mesh sieve sieves
Point, mixing, it is that to add volume fraction be the ethanol of 40% to 12:1 by liquid material mass ratio, soaks after 2h, under 50MPa extracts pressure
Carrying out normal temperature extraction with high pressure homogenization method machine, after extract is performing centrifugal separation on, concentrate with film, concentrate macroreticular resin is inhaled
Attached, then with volume fraction be 30～90% ethanol repeatedly elute, collect eluent, film is concentrated into the matter of extract and autonomic drug
Amount ratio is 1:1, adds the butanediol with extract uniform quality and dissolves, filter, prepares autonomic drug composition.
The preparation of embodiment 3 autonomic drug composition (III)
Take red sage root 40g, granatum 15g, oldenlandia diffusa 18g, curcuma zedoary 12g, Radix Glycyrrhizae 15g, pulverize, respectively with 40 mesh sieve sieves
Point, mixing, it is that to add volume fraction be the ethanol of 50% to 10:1 by liquid material mass ratio, soaks after 3h, under 60MPa extracts pressure
Carrying out normal temperature extraction with high pressure homogenization method machine, after extract is performing centrifugal separation on, concentrate with film, concentrate macroreticular resin is inhaled
Attached, then with volume fraction be 10～95% ethanol repeatedly elute, collect eluent, film is concentrated into the matter of extract and autonomic drug
Amount ratio is 1:1, adds the butanediol with extract uniform quality and dissolves, filter, prepares autonomic drug composition.
The preparation of embodiment 4 autonomic drug composition (IV)
Take red sage root 32g, granatum 18g, oldenlandia diffusa 15g, curcuma zedoary 15g, Radix Glycyrrhizae 20g, pulverize, respectively with 60 mesh sieve sieves
Point, mixing, it is that to add volume fraction be the ethanol of 40% to 12:1 by liquid material mass ratio, soaks after 2h, under 50MPa extracts pressure
Carrying out normal temperature extraction with high pressure homogenization method machine, after extract is performing centrifugal separation on, concentrate with film, concentrate macroreticular resin is inhaled
Attached, then with volume fraction be 30～90% ethanol repeatedly elute, collect eluent, film is concentrated into the matter of extract and autonomic drug
Amount ratio is 1:1, adds the butanediol with extract uniform quality and dissolves, filter, prepares autonomic drug composition.
Test example 1 minimal inhibitory concentration (MIC) is tested
Take the culture dish containing different autonomic drug composition concentration gradients, draw corresponding the dripping for examination bacterium of 0.1 mL with aseptic straw
In above-mentioned culture dish, smoothen with aseptic L-type glass bar, at 37 DEG C, cultivate 24h, with sterilized water, blank extract and extraction
Thing diluent compares, and records observed result.With the MIC that least concentration is this extract entirely without thalli growth.Detection
The results are shown in Table shown in 1.
The MIC (mg/L) of the various bacterium of table 1
| Sequence number | Pseudomonas | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| 1 | Propionibacterium acnes | 15 | 14 | 16 | 15 |
| 2 | Escherichia coli | 18 | 16 | 21 | 19 |
| 3 | Staphylococcus aureus | 19 | 20 | 19 | 18 |
| 4 | Candida albicans | 11 | 10 | 9 | 12 |
As can be seen from Table 1, the autonomic drug composition that prepared by the present invention is multiple to propionibacterium acnes that can cause an acne etc.
Bacterium has good inhibition.
Test example 2 controls oil effect functional evaluation
1, sample is evaluated
The autonomic drug composition 50g of Example 1 preparation, is diluted to 1000g as sample by deionized water, carries out following skin
Oil content is tested.
2, tester
The tester of the test of skin oil and fat content is the skin that Courage+Khazaka company of Germany (CK company of Germany) manufactures
Skin fat content Sebumeter tests probe.
3, method of testing
The method of testing of skin oil and fat content is to use universally acknowledged SEBUMETER method, and the method is as follows:
Choosing the volunteer 40 of Oily, the age, men and women half and half 20～35 years old.Volunteer in first 30 days of on-test not
Any control oil product can be used, such as cosmetics or topical drug or health products for oral administration etc..Before test, it is desirable to experimenter cleans face
Portion also enters temperature 22 ± 1 DEG C in 2 hours after cleaning, and sit quietly in the constant temperature and humidity room of humidity 50 ± 5% 30min, and keeps putting
Pine state.Experiment is chosen by random table the left and right forehead of volunteer, takes glabella center line and intersecting away from upper eyebrow edge 1cm parallel lines
Point is test midpoint, puts the most in testing and respectively tests a position to from left to right, takes the mean value of 3 values as forehead
The data of grease.After test terminates, volunteer needs the sample that every day carries out full face each 1 time sooner or later on request to smear, and blank example is used
Deionized water substitutes, 28 days the most on probation, and requires paying a return visit for the 14th day and the 28th day of test.
4, evaluation result
Result shows, after using 14 days, the skin oil and fat of volunteer declines 24.7%；After using 28 days, the skin oil and fat of volunteer
Decline 35.6%.This explanation present invention has autonomic drug composition and skin oil and fat secretion is had obvious inhibition, has good control
Oil effect.
Embodiment 5 acne eliminating cream and preparation method thereof
Table 2 provides the acne eliminating cream formula containing autonomic drug composition, and the consumption mass fraction of each material represents.
Table 2
The preparation method of acne eliminating cream: by the dimethyl siloxane in formula table, isopropyl palmitate, Miglyol 812, list
Sweet ester, stearic acid, 1618 alcohol, cetearyl glucoside, polyglycereol-3-methyl distearate, methyl hydroxybenzoate, Buddhist nun
Pool gold propyl ester mixing, is heated to 80 DEG C, and fusing stirs, as oil phase；By the 1,2-propane diols in formula table, autonomic drug
Composition, deionized water mix, and join emulsification pot and are heated to 85 DEG C, and stirring and dissolving is uniform, as aqueous phase.Oil phase is added
Entering in aqueous phase, stir, emulsifying homogeneous is after 6 minutes, when stirring is cooled to 50 DEG C, adds essence, stirs, cooling
To 38 DEG C, it is acne eliminating cream.
Embodiment 6 acne removing water and preparation method thereof
Table 3 provides the acne removing water formula containing autonomic drug composition, and the consumption mass fraction of each material represents.
Table 3
The preparation method of acne removing water: deionized water is heated to 85 DEG C, adds hydroxyethyl cellulose, and stirring and dissolving is uniform, adds 1,
3-butanediol.When stirring is cooled to 50 DEG C, add other compositions, continue stirring and be cooled to 38 DEG C, be acne removing water.
Embodiment 7 Deacne pack and preparation method
Table 4 provides the Deacne pack formula of liquid containing autonomic drug composition, and the consumption mass fraction of each material represents.
Table 4
The preparation method of Deacne pack liquid: deionized water is heated to 80 DEG C, adds xylitol, and stirring and dissolving is uniform, adds glycerine
With Sodium Hyaluronate mixture, add methyl hydroxybenzoate and propylben after stirring and dissolving, continue stirring and dissolving, be cooled to 50
DEG C time, add other compositions, continue stirring and be cooled to 38 DEG C, be Deacne pack liquid.
Deacne pack liquid adds in the face paper folded, and packs, is Deacne pack.
Test example 3 anti-acne effect evaluation
Evaluation object: choosing bilateral face has obvious acne, is in new life or inflammatory phase, and facial area skin belongs to easy long powder
Thorn type volunteer 40 example, the wherein male sex 20 example, women 20 example.
Evaluation method: after using double-blind study, every morning washed, the acne removing water 3g of Example 2 preparation is applied on the face
There is the position of acne, be coated with again once after washed before sleep in evening, within 28 days, be a course for the treatment of.
Evaluation criterion: the most effective: acne fading more than 70%；The most effective: acne fading more than 30%；The most invalid: acne disappears
Take off less than 30%.
Evaluation result: effective 15 examples, accounts for 37.5%；Effective 17 examples, account for 42.5%；Invalid 8 examples, account for 20%.Total effective rate reaches
80%.The anti-acne effect that acne removing water prepared by the autonomic drug composition of this explanation present invention is good to whelk.
Therefore, the autonomic drug composition of the present invention can suppress skin oil and fat to secrete, and effectively suppresses propionibacterium acnes, well
Acne-removing, Long-Time Service can strengthen skin resistance, improve skin quality, allows skin permeation only feel well, soft and smooth exquisiteness.
Claims (2)
1. an autonomic drug composition with acne-removal function, it is characterised in that by the autonomic drug component system of following percentage by weight
Become: the red sage root 5～50%, granatum 5～40%, oldenlandia diffusa 2～35%, curcuma zedoary 2～30%, Radix Glycyrrhizae 2～40%；Autonomic drug combines
The preparation scheme of thing is: by autonomic drug pulverize, respectively with 20～100 mesh sieve screening, mix, by liquid material mass ratio be 5:1～
20:1 adds Extraction solvent, after soaking 1～5h, carries out normal temperature with high pressure homogenization method machine and carry under 10～100MPa extraction pressure
Take, after extract is performing centrifugal separation on, concentrate with film, concentrate macroporous resin adsorption, then by the second that volume fraction is 10～95%
Alcohol repeatedly elutes, and collects eluent, and it is 1:0.1～1:5 that film is concentrated into the mass ratio of extract and autonomic drug, adds butanediol
Dissolve, filter, prepare autonomic drug composition；Extraction solvent is water, ethanol or ethanol water.
2. the application in acne-eliminating cosmetic of the autonomic drug composition described in claim 1, it is characterised in that in acne-eliminating cosmetic
Containing above-mentioned autonomic drug composition, its consumption is calculated as 0.01 ~ 25% with mass fraction.
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| CN106389204A (en) * | 2016-10-23 | 2017-02-15 | 广东轻工职业技术学院 | Botanical drug composition with both functions of oil controlling and pox removing and application of botanical drug composition |
| CN106420490A (en) * | 2016-11-18 | 2017-02-22 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with effect of removing acne and preparation method and application of traditional Chinese medicine composition |
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| CN111265456A (en) * | 2020-04-27 | 2020-06-12 | 深圳市千羽寒医化生物科技有限公司 | Acne-removing composition and application thereof |
| CN111686179A (en) * | 2020-06-15 | 2020-09-22 | 广东轻工职业技术学院 | Traditional Chinese medicine compound extract with acne removing and red blood streak removing effects and preparation and application thereof |
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| CN106420490A (en) * | 2016-11-18 | 2017-02-22 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with effect of removing acne and preparation method and application of traditional Chinese medicine composition |
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| CN109846771A (en) * | 2018-07-05 | 2019-06-07 | 上海珈凯生物科技有限公司 | A kind of composition of plant extracts and preparation method thereof with acne-removing |
| CN108904376A (en) * | 2018-08-02 | 2018-11-30 | 广东轻工职业技术学院 | It is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal and its preparation and application |
| CN108904376B (en) * | 2018-08-02 | 2020-07-10 | 广东赛安特新材料有限公司 | Traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects and preparation and application thereof |
| CN111265456A (en) * | 2020-04-27 | 2020-06-12 | 深圳市千羽寒医化生物科技有限公司 | Acne-removing composition and application thereof |
| CN111686179A (en) * | 2020-06-15 | 2020-09-22 | 广东轻工职业技术学院 | Traditional Chinese medicine compound extract with acne removing and red blood streak removing effects and preparation and application thereof |
| CN111686179B (en) * | 2020-06-15 | 2021-09-10 | 广州市衡拓贸易有限公司 | Traditional Chinese medicine compound extract with acne removing and red blood streak removing effects and application thereof |
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Application publication date: 20160810 |