CN101011483A - Chinese medicinal formulation for treating children's digestive system disease and its preparation method - Google Patents
Chinese medicinal formulation for treating children's digestive system disease and its preparation method Download PDFInfo
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- CN101011483A CN101011483A CNA2007102002105A CN200710200210A CN101011483A CN 101011483 A CN101011483 A CN 101011483A CN A2007102002105 A CNA2007102002105 A CN A2007102002105A CN 200710200210 A CN200710200210 A CN 200710200210A CN 101011483 A CN101011483 A CN 101011483A
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Abstract
The invention relates to a traditional medicine agent used to treat alimentary system disease of children, and relative preparation. The invention uses evodia rutaecarpa, pepper, Cinnamomum cassia, clove and bighead atractylodes rhizome; processes ultra-critical fluid extraction, distilling in steam, and organic solvent extraction, to extract the benzene to be mixed with borneol and litsea cubeba oil, adding some findings to prepare the drug. The inventive drug has the functions as promoting digestion, or the like.
Description
Technical field: the present invention relates to a kind of Chinese medicine preparation for the treatment of children's digestive system disease and preparation method thereof, belong to technical field of Chinese medicine.
Background technology:
Show that according to relevant current research child's proportion in whole world population is increasing, particularly in the Asia, child's sum has accounted for 77% of whole world child's population.The sales amount of medicine that the child uses also obviously increases, and total value was 87.3 hundred million dollars in 2002, may reach 144.8 hundred million dollars by 2010.Children has good growth momentum.In pediatric disease, take place the most general with respiratory system disease and digestive tract disease.Portion investigation according to The World Health Organization (WHO) shows that digestive tract disease is the highest disease of the child of developing country sickness rate.Wherein digest and assimilate badly in the digestive system disease, influence growth promoter.Particularly 3 years old with interior children's, and this stage is brain development the most vigorous period just, is the critical period of decision intelligence height, if digestive function fails in time to improve, influence the absorption of nutrient, certainly will influence brain development and all the life sorry.In China 8.36 hundred million people's subinfections diarrhoea is arranged every year, wherein child below 5 years old reaches 300,000,000 person-times.The medicine of treatment infantile diarrhea has antibiotics at present, and intestinal mucosa protective agent also has diarrhea etc.; but antibacterials are widely applied and can be destroyed microecological balance, cause superinfection easily, and its consequence is even more serious; and intestinal mucosa protective agent can influence the other drug absorption, is unfavorable for the stable of the state of an illness.Through investigation, the pharmaceutical preparation of the little digestive system disease of whole body drug treatment still appears adopting in the market.
Summary of the invention:
The objective of the invention is to: provide a kind of evident in efficacy and be easy to Chinese medicine preparation of the treatment children's digestive system disease that the child accepts and preparation method thereof, to solve the problem that prior art exists.
The present invention is achieved in that the Chinese medicine preparation of treatment children's digestive system disease, calculate according to composition by weight, it is by 0.0038～0.114 part of Fructus cinnamomi camphorae oil, 0.5～3 parts, 1～3.5 part of Fructus Evodiae, 2～4 parts in Fructus Piperis, 1～3.5 part of Cortex Cinnamomi, 2～4 parts of Flos Caryophyllis, 2～5 parts of the Rhizoma Atractylodis Macrocephalaes, Borneolum Syntheticum is prepared from for 0.5～2 part.
Say accurately, calculate that it is by Fructus cinnamomi camphorae oil 0.0038g according to weight, Fructus Evodiae 1g, Fructus Piperis 1g, Cortex Cinnamomi 1g, Flos Caryophylli 1g, Rhizoma Atractylodis Macrocephalae 1g, Borneolum Syntheticum 1g is prepared from.
The Chinese medicine preparation of treatment children's digestive system disease of the present invention is preparation like this: get Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, is put in the volatile oil extractor, adds the water of 8～12 times of weight, extracts 8～10 hours, obtains Aromatic water and volatile oil, lumps together the Fructus cinnamomi camphorae oil of volatile oil and recipe quantity standby; Edible ethanol dissolving Borneolum Syntheticum with 80～98% mixes with the mixture of Fructus cinnamomi camphorae oil with above-mentioned Aromatic water or volatile oil, adds suitable adjuvant then, is prepared into required Chinese medicine preparation.
The middle Medicatedbath lotion that the present invention treats children's digestive system disease prepares like this: get Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, is put in the volatile oil extractor, adds the water of 8～12 times of weight, extracts 8～10 hours, obtains Aromatic water and volatile oil, and the Fructus cinnamomi camphorae oil of volatile oil and recipe quantity is lumped together, and is standby; Edible ethanol dissolving Borneolum Syntheticum with 80～98%, mix with the mixture of Fructus cinnamomi camphorae oil with above-mentioned volatile oil, obtain volatile oil and Borneolum Syntheticum mixture, then according to volatile oil and Borneolum Syntheticum mixture: anhydrous lanolin lanolin wax sorbitan: ethoxylation sorbitol anhydride fatty acid fat: propyl p-hydroxybenzoate: deionized water: fatty acid: phenylpropanol: quaternary ammonium salt cationic emulsifying agent: methyl parahydroxybenzoate is 2～5: 2～4: 0.2～0.6: 1～4: 0.1～0.2: 91.4～81.9: 0.5～1.5: 1～2: 0.2～0.6: 0.1～0.2 weight portion ratio, mentioned component mix homogeneously post-heating to 75 ℃ is stirred to cooling, promptly.
The Chinese medicine patch unguentum that the present invention treats children's digestive system disease prepares like this: get Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder,, be put in the volatile oil extractor, add the water of 8～12 times of weight, extracted 8～10 hours, obtain Aromatic water and volatile oil, volatile oil and Fructus cinnamomi camphorae oil are lumped together, standby; Edible ethanol dissolving Borneolum Syntheticum with 80～98%, mix with the mixture of Fructus cinnamomi camphorae oil with above-mentioned volatile oil, obtain volatile oil and Borneolum Syntheticum mixture, then according to volatile oil and Borneolum Syntheticum mixture: arabic gum: gelatin: polyvinyl alcohol: cross-linking sodium carboxymethyl cellulose: polyvinylpyrrolidone: glycerol: zinc oxide is 0.2～0.6: 0.5～3.5: 0.5～3.5: 0.2～3.5: 0.5～1.5: 0.6～4: 6～15: 0.1 weight portion ratio, with arabic gum, gelatin, polyvinyl alcohol, mix homogeneously dissolved after polyvinylpyrrolidone added an amount of water, after the adding zinc oxide stirs evenly, adding glycerol again stirs evenly, pour in the mortar and to add cross-linking sodium carboxymethyl cellulose and grind well, add volatile matter and Borneolum Syntheticum mixture, adding volatile oil behind the mix homogeneously fully grinds, at the last figure cloth of crust cloth cream coating instrument, naturally dry to moisture 30% o'clock epiphragma of mastic, promptly.
The distillate medicinal water that the present invention treats children's digestive system disease prepares like this: get Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, is put in the volatile oil extractor, the water that adds 8～12 times of weight, extracted 8～10 hours, and obtained Aromatic water and volatile oil, use the filter paper of moistening to filter the Aromatic water that obtains, the Fructus cinnamomi camphorae oil of recipe quantity is added purified talc 15g by volatile oil 2ml, grind well, moistening filter paper filters and makes Aromatic water behind the adding distil water 1000ml, and two kinds of Aromatic water are lumped together; Edible ethanol dissolving Borneolum Syntheticum with 80～98% mixes with above-mentioned Aromatic water, with the filter paper filtration of moistening, promptly.
The Chinese medicine preparation of treatment children's digestive system disease of the present invention also can prepare like this: get Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum, with Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, is that 15～20MP, temperature are 45～50 ℃ in extracting pressure, and flow is under the condition of 10～15kg/h, extract its volatile oil with supercritical carbon dioxide extraction apparatus, standby; With 80～98% edible ethanol dissolving Borneolum Syntheticum, mix with above-mentioned volatile oil and Fructus cinnamomi camphorae oil, the total volatile oil that obtains and the mixture of Borneolum Syntheticum are added suitable adjuvant, are prepared into required Chinese medicine preparation.
The Chinese medicine preparation of treatment children's digestive system disease of the present invention can also prepare like this: get Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, adds 3～5 times of weight, boiling ranges and be 30～60 petroleum ether as solvent extraction, and dipping extracts 1～3 time, and each 8～24 hours, filter, the gained extract volatilizes in 40～60 ℃ of water-baths, and is standby; With 80～98% edible ethanol dissolving Borneolum Syntheticum, volatilize extract behind the solvent and the Fructus cinnamomi camphorae oil of recipe quantity mixes with above-mentioned, add suitable adjuvant then, be prepared into required Chinese medicine preparation.
Pharmaceutical formulation tool warming spleen and stomach for dispelling cold of the present invention, supporing yang antidiarrheal, invigorating the spleen and regulating the stomach, the effect of pain relieving cures mainly Deficiency and coldness of spleen and stomach disease.Disease is seen coldness and pain in the epigastrium, dyspepsia, and vomiting with acid regurgitation is liked warm pain relieved by pressing, and extremity are not warm, and pallor is not magnificent, tastelessness and no thirst, loose stool, pale tongue with white fur China, deep-slow pulse.Miao Ethnomedicine Fructus cinnamomi camphorae in the side and Fructus Evodiae are as the classical medicine of Miao ethnic group's tradition benefiting stomach and stopping pain, modern pharmacological research confirms, the diarrhoea that the volatile ingredient of medicine causes because of Oleum Ricini mice in this side and certain inhibitory action is all arranged by the diarrhoea that Folium Sennae causes, and can obviously reduce the mouse writhing reaction times that glacial acetic acid causes.The cold diarrhoea and the diarrhea due to hypofunction of the spleen that cause for treatment diseases caused by exogenous pathogenic factor ailment said due to cold or exposure all have certain theory and clinical basis.
Traditional Chinese medical science cloud: weakness of spleen-YANG, deficiency-cold in middle-JIAO causes taste to lose in replenishing vital QI with drugs of warm nature and pain.Deficient and weak YANG QI, warm effect weaken that extremity to occur not warm, and pallor is simple and unadorned.Deficiency and coldness of spleen and stomach, it is unable to gasify, and then loose stool is weighed in the fortuneization mistake, pale tongue with white fur China, deep-slow pulse is deficiency of YIN performance.Fructus cinnamomi camphorae hardship among the we, suffering, temperature is returned stomach, the heart, large intestine channel Cortex Cinnamomi Xin Ganre, returns spleen, kidney, conscience warp; Fructus Piperis is hot, returns stomach, large intestine channel; Two medicine warming middle-JIAO are supporing yang, dispersing cold for relieving pain, so be monarch drug, minister is with Fructus Evodiae, Flos Caryophylli, dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.The Rhizoma Atractylodis Macrocephalae is a minister, and air making-up and spleen enlivening recovers transformation and transportation of the spleen and stomach, and assistant is with Borneolum Syntheticum, and working hard is slightly cold, and the side's of avoiding taste of Chinese medicine is too hot, increases the effect of pain relieving.
The present invention is thin according to children's's keratodermatitis, good physiological characteristics of permeability and morbidity easily, spread all over rapidly, the more weak pathological characteristic of infant metabolic function, merge modern transdermal administration technology, Medicatedbath lotion and Chinese medicine patch unguentum, distillate medicinal water during medicine is prepared into after extracting.Adopt modern extraction process to carry out the extraction of effective ingredient on the one hand after making the bath agent, utilization rate of active components is improved through extracting after refining, and kept the active constituent content of each flavour of a drug in the prescription to the full extent, and drug action is more lasting, and bioavailability is higher; Adopt on the other hand and bathe agent and this dosage form of distillate medicinal water, can play the double effects of taking a shower with disease-relieving and physique enhancing, it can be by the strength of warm water, the sweat gland of skin is unfolded, the horny layer aquation is abundant, is beneficial to seeing through of medicine and absorbs, simultaneously because employing is the whole body administration, can guarantee that medicine reaches maximum in vivo and effectively accumulates in the short time, the effect of messenger drug power is more rapid.Adopt this dosage form of patch, reduced former medicine itself, can make medicine directly act on the infant umbilical part children's's skin irritation, the efficacy of a drug SHENQUE acupoint of go directly, convenient drug administration acts on lastingly, and is evident in efficacy, uses easy to carryly, avoids medicated clothing is polluted.Concerning infant, no pain stimulates little.Infant and family members thereof easily accept.
Be the drug effect of checking medicine of the present invention, the applicant has carried out a large amount of tests, and its result is as follows:
One, the pharmacodynamics test of middle Medicatedbath lotion of the present invention:
1. the Medicatedbath lotion Dichlorodiphenyl Acetate causes the analgesic activity of pain mice in of the present invention:
1.1 grouping and drug dose: get 40 of rats, arranging in pairs or groups at random by body weight is divided into 4 groups, and 10 every group, male and female half and half, conduct respectively: 1. blank group: the excipient that does not contain principal agent; 10.5,7,3.5ml/kg 2.～4. the large, medium and small three kinds of dosage groups of Medicatedbath lotion in of the present invention:, be respectively 15,10,5 times of clinical plan consumption); With the mice processing of shedding, raised for 1 week down in 38 ± 1 ℃ of greenhouse experiments of room temperature, under 38 ± 1 ℃ of conditions of water temperature, mixed in water by the said ratio requirement by the reagent thing, with in the rat dipping bath water (except that head).Every day 3 times, each 15 minutes.Successive administration 2 days in the 2nd day lumbar injection 0.6% acetic acid 0.2ml/10g of administration, during simultaneously with the stopwatch utmost point, writes down each Mus and occurs turning round the body number of times in 1 writhing response time and 10 minutes, the results are shown in Table 1.
1.2 result:
The Medicatedbath lotion Dichlorodiphenyl Acetate caused the analgesic activity (n=10 of pain mice during table 1 was of the present invention
)
| Group | Incubation period | Turn round the body number of times | The analgesia rate |
| Vehicle group | 3.57±1.40 | 31.9±9.0* | |
| Heavy dose of group | 6.19±2.80* | 17.3±11.18* | 45.8 |
| Middle dosage group | 7.15±2.78** | 13.5±6.9** | 57.7 |
| Small dose group | 6.91±3.53* | 14.8±6.8** | 53.6 |
Annotate: compare with vehicle group
*P＜0.05,
*P＜0.01
The result shows: Medicatedbath lotion is big in of the present invention, in, small dose group all can prolong mice analgesia incubation period, and can reduce mice turn round the body number of times, illustrate that this bath agent has significant analgesia role.
2. the anti-diarrhea effect that Medicatedbath lotion is had loose bowels to rat due to the Folium Sennae in of the present invention:
2.1 principle: drugs for dispelling internal cold has warming spleen and stomach for dispelling cold, and the merit that spleen invigorating is supporing yang can be used for Deficiency and coldness of spleen and stomach, it " diarrhea due to cold pathogen ", " diarrhea of deficiency type " due to the fortuneization imbalance.Folium Sennae is the laxative that acts on large intestine, and cathartic relaxes due to it, and loose and watery stool is half congealed and do not have a foreign odor, approximate " diarrhea due to cold pathogen ", " diarrhea of deficiency type ".So with this model of having loose bowels, " warming middle-JIAO to stop diarrhea " effect that can observe warming the interior side's medicine.
2.2 material:
Animal: rat.
Equipment: mouse cage, absorbent paper, balance.
Medicine and reagent: Folium Sennae, be ground into fine powder, be mixed with 8% suspension with boiling water; Medicatedbath lotion in of the present invention.
2.3 test method:
2.3.1. choose 30 of purebred, the healthy rats of body weight 18～22g, male or male and female half and half, grouping immediately, sub-cage rearing, every Mus one cage (or lattice).
2.3.2. administration: press crude drug 0.7ml/kg bathing with Medicatedbath lotion in of the present invention, every day 2 times, successive administration three days, matched group wait capacity dressing except that principal agent.
2.3.3. give Folium Sennae: after the last administration one hour, press 2g crude drug/kg (8% medicinal liquid 0.5ml/20g) filling stomach with 8% Garfields Tea suspension.
2.3.4. counting muck: the cage lower berth is put absorbent paper and is made muck counting, with muck what, expression diarrhoea degree.Give behind the Folium Sennae 1～6 hour, per hour change absorbent paper once, make last counting after 7～24 hours.
2.3.5. calculate 24 hours muck sums of each Mus, data are done the t check, relatively each administration group and matched group muck are counted the significance of difference.See Table 2
The influence that Medicatedbath lotion was had loose bowels to rat due to the Folium Sennae during table 2 was of the present invention
| Group | Dosage (ml/kg) | Number of animals | Muck number (individual/24 hour) x ± SD |
| Medicatedbath lotion during matched group is of the present invention | The outer adjuvant 0.7 0.7 of crack principal agent | 10 10 | 7.2±12 1.3±1.0 |
2.4 result: after matched group was given Folium Sennae, the mice muck increased, and showed the symptom of having loose bowels.Medicatedbath lotion all can make mice muck number obviously reduce in of the present invention, shows that this bath agent is to the anti-diarrhea effect of having had loose bowels due to the Folium Sennae.
Two, the clinical trial of middle Medicatedbath lotion of the present invention:
(1) treatment infantile diarrhea observation of curative effect:
1. case grouping: diagnosis diarrhoea infant 80 examples, at random infant is divided into treatment group and matched group, wherein 60 examples are organized in treatment, matched group 20 examples, two groups of cases are learned processing by statistics, and two groups of patient age, sex, the course of disease, state of an illness there are no significant difference has comparability.See Table 3.
Table 3 treatment group and matched group distribution situation
| Group | The example number | Sex 1. | Age 2. | Have or not dehydration 3. | The course of disease 4. before going to a doctor | |||
| The man | The woman | June～1 years old | 1 year old～2 years old | Have | Do not have | |||
| The treatment group | 60 | 31 | 29 | 33 | 27 | 11 | 49 | 2.45±1.21 |
| Matched group | 20 | 11 | 9 | 12 | 8 | 6 | 14 | 2.08±1.18 |
Annotate: 1. x
2=0.26, p＞0.05x
2=0.08, p＞0.05x
2=0.21, p＞0.05 is t=1.25 4., p＞0.05
2. Therapeutic Method and evaluation index: matched group adopts conventional treatments, and Chinese medicine preparation such as oral huoxiang zhengqi powder, Gegen Huangqin Huanglian Tang are given in determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs.The treatment group adopts middle Medicatedbath lotion dipping bath whole body of the present invention.Every day twice, each 15～20 minutes, 2～5 days courses of treatment.Matched group and treatment group infant all can be aided with oral rehydration if dehydration is arranged.Everyone situations such as character, times of defecation of defecating of treatment group equal itemized record every day.Curative effect determinate standard is: (in 5 days) judge curative effect in the course of treatment.Produce effects: to treat 24～48 hours, times of defecation is reduced to≤and 2 times/day or return to normal number of times, the stool character recovers normal, clinical symptom disappearance.Effectively: to treat 48～72 hours, times of defecation just is reduced to≤and 2 times/day, the stool character takes a turn for the better, and moisture obviously reduces, and clinical symptoms disappears substantially.Invalid: treat after 72 hours, the diarrhoea number of times still＞2 time/day or character do not have and be clearly better, even the state of an illness increases the weight of and changes the medicine person is all invalid.
3. interpretation of result: treatment group produce effects 19 examples, effective 31 examples, invalid 10 examples, total effective rate 83.3%; Matched group produce effects 7 examples, effective 10 examples, invalid 10 examples, total effective rate 85.0%.Learn Treatment Analysis by statistics, treatment group and matched group efficacy result there was no significant difference (x
2=0.09, p＞0.05).And treatment group no pain and other toxic and side effects more are preferably infant and accept.
(2) treatment infantile dyspepsia 46 routine observation of curative effect:
1. clinical data:
1.1 the age and the course of disease: in 46 routine dyspepsia infants, 6 months 14 examples of less than (accounting for 32.4%), 6 months～1 years old 22 example (accounting for 47.8%), 1 years old～3 years old 8 example (accounting for 17.4%), 3 years old～7 years old 2 example (accounting for 4.3%); The shortest person of the course of disease 3 days, elder 20 days.
1.2 symptom and laboratory examination: in 46 routine infants, loss of appetite, abdominal distention 33 examples (accounting for 71.7%), the vomiting or milk 25 examples (accounting for 32.6%) of overflowing, 40 examples of suffering from diarrhoea (accounting for 86.9%); Times of defecation every day 〉=10 time person 12 examples (accounting for 23.9%) wherein ,≤10 person's 19 examples (accounting for 41.3%), 4～5 person's 8 examples (accounting for 17.3%).Stomachache person's 7 examples (accounting for 15.2%).Stool routine examination is leukocyte≤3/HP or significant quantities of fat ball, no erythrocyte or pus cell, and the stool antibacterial culturing does not have the pathogenic bacterium growth.
2. treatment:, give lotion of the present invention by the bathing of crude drug 0.7ml/kg whole body, every day 2 times, successive administration 3 days according to infant clinical manifestation and age to promote that gastro-intestinal digestion is absorbed as the rule of treatment.Be 1 week of the lighter the course of treatment, heavy person 10 days.
3. curative effect determinate standard:
Cure: the clinical symptoms complete obiteration, stool is less than 4 times every day, and shape is normal, stool microscopy ();
Take a turn for the better: clinical symptom disappearance or obviously alleviate, times of defecation obviously reduces before the treatment, and form takes a turn for the better, in the stool microscopy Oil globule 10;
Invalid: clinical symptoms does not have obvious improvement, and times of defecation, form and other clinical symptoms do not have obvious improvement, the stool microscopy with the treatment before compare no significant change.
4. result: cure 40 examples (accounting for 87%) in the 46 routine dyspepsia infants, 14 examples that take a turn for the better, invalid 1 example (because of vomiting can not be taken medicine).The course of treatment is the shortest 3 days.
The specific embodiment:
Embodiments of the invention 1: get Fructus Evodiae 1g, Fructus Piperis 1g, Cortex Cinnamomi 1g, Flos Caryophylli 1g, Rhizoma Atractylodis Macrocephalae 1g, Borneolum Syntheticum 1g; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, with Fructus cinnamomi camphorae oil, is put in the volatile oil extractor, adds the water of 11 times of weight, extracts 9 hours, obtains Aromatic water and volatile oil, and is standby; The Fructus cinnamomi camphorae oil of above-mentioned volatile oil and 0.038g is lumped together, standby; Edible ethanol dissolving Borneolum Syntheticum with 80～98%, mix with the mixture of Fructus cinnamomi camphorae oil with above-mentioned volatile oil, obtain volatile oil and Borneolum Syntheticum mixture, then according to volatile oil and Borneolum Syntheticum mixture: anhydrous lanolin lanolin wax sorbitan: ethoxylation sorbitol anhydride fatty acid fat: propyl p-hydroxybenzoate: deionized water: fatty acid: phenylpropanol: quaternary ammonium salt cationic emulsifying agent: methyl parahydroxybenzoate is 5: 4: 0.4: 3: 0.1: 83.9: 1: 2: 0.5: 0.1 weight portion ratio, mentioned component mix homogeneously post-heating to 75 ℃ is stirred to cooling, promptly obtains the middle Medicatedbath lotion that the present invention treats children's digestive system disease.The external of this product.After getting said preparation allotment (according to every 5ml → 10000ml warm water), the infant dipping bath was wherein got final product twice of every day in 10 minutes.
The embodiment of the invention 2: get Fructus Evodiae 1g, Fructus Piperis 2g, Cortex Cinnamomi 1g, Flos Caryophylli 2g, Rhizoma Atractylodis Macrocephalae 2g, Borneolum Syntheticum 0.5g; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, is put in the volatile oil extractor, adds the water of 8 times of weight, extracts 8 hours, obtains Aromatic water and volatile oil, and the Fructus cinnamomi camphorae oil of above-mentioned volatile oil and 0.072g is lumped together, and is standby; Edible ethanol dissolving Borneolum Syntheticum with 80～98%, mix with the mixture of Fructus cinnamomi camphorae oil with above-mentioned volatile oil, obtain volatile oil and Borneolum Syntheticum mixture, then according to volatile oil and Borneolum Syntheticum mixture: arabic gum: gelatin: polyvinyl alcohol (PVA): cross-linking sodium carboxymethyl cellulose (CMC-Na): polyvinylpyrrolidone (PVP): glycerol: zinc oxide is 0.3: 1.5: 2: 0.4: 1: 2.5: 8: 0.1 weight portion ratio, with arabic gum, gelatin, polyvinyl alcohol (PVA), mix homogeneously dissolved after polyvinylpyrrolidone (PVP) added an amount of water, after the adding zinc oxide stirs evenly, adding glycerol again stirs evenly, pour into and add cross-linking sodium carboxymethyl cellulose (CMC-Na) in the mortar and grind well, add volatile matter and Borneolum Syntheticum mixture, adding volatile oil behind the mix homogeneously fully grinds, at the last figure cloth of crust cloth cream coating instrument, naturally dry to moisture 30% o'clock epiphragma of mastic, promptly get the Chinese medicine patch unguentum that the present invention treats children's digestive system disease.Mastic thickness is 0.5mm.The external of this product.Be affixed on umbilical part, one time one subsides were changed dressings once in 24 hours.
The embodiment of the invention 3: get Fructus Evodiae 3.5g, Fructus Piperis 4g, Cortex Cinnamomi 3.5g, Flos Caryophylli 4g, Rhizoma Atractylodis Macrocephalae 5g; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, is put in the volatile oil extractor, the water that adds 12 times of weight, extracted 10 hours, and obtained Aromatic water and volatile oil, use the filter paper of moistening to filter the Aromatic water that obtains, Fructus cinnamomi camphorae oil with 0.114g, add purified talc 15g by volatile oil 2ml, grind well, moistening filter paper filters and makes Aromatic water behind the adding distil water 1000ml, two kinds of Aromatic water are lumped together, with 80～98% edible ethanol dissolving Borneolum Syntheticum, the filter paper that mixes with moistening with above-mentioned Aromatic water filters, and promptly gets the distillate medicinal water that the present invention treats children's digestive system disease.
The embodiment of the invention 4: get Fructus Evodiae 1g, Fructus Piperis 1g, Cortex Cinnamomi 1g, Flos Caryophylli 1g, Rhizoma Atractylodis Macrocephalae 1g, Borneolum Syntheticum 1g; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, and is that 15～20MP, temperature are 45～50 ℃ in extracting pressure, flow is under the condition of 10～15kg/h, extract its volatile oil with supercritical carbon dioxide extraction apparatus, the Fructus cinnamomi camphorae oil of above-mentioned volatile oil and 0.038g is lumped together, standby; Edible ethanol dissolving Borneolum Syntheticum with 80～98%, mix with the mixture of Fructus cinnamomi camphorae oil with above-mentioned volatile oil, obtain volatile oil and Borneolum Syntheticum mixture, then according to volatile oil and Borneolum Syntheticum mixture: anhydrous lanolin lanolin wax sorbitan: ethoxylation sorbitol anhydride fatty acid fat: propyl p-hydroxybenzoate: deionized water: fatty acid: phenylpropanol: quaternary ammonium salt cationic emulsifying agent: methyl parahydroxybenzoate is 5: 4: 0.4: 3: 0.1: 83.9: 1: 2: 0.5: 0.1 weight portion ratio, mentioned component mix homogeneously post-heating to 75 ℃ is stirred to cooling, promptly obtains the middle Medicatedbath lotion that the present invention treats children's digestive system disease.
The embodiment of the invention 5: get Fructus Evodiae 1g, Fructus Piperis 2g, Cortex Cinnamomi 1g, Flos Caryophylli 2g, Rhizoma Atractylodis Macrocephalae 2g, Borneolum Syntheticum 0.5g; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, is that 15～20MP, temperature are 45～50 ℃ in extracting pressure, flow is under the condition of 10～15kg/h, extract its volatile oil with supercritical carbon dioxide extraction apparatus, the Fructus cinnamomi camphorae oil of above-mentioned volatile oil and 0.072g is lumped together, standby; Edible ethanol dissolving Borneolum Syntheticum with 80～98%, mix with the mixture of Fructus cinnamomi camphorae oil with above-mentioned volatile oil, obtain volatile oil and Borneolum Syntheticum mixture, then according to volatile oil and Borneolum Syntheticum mixture: arabic gum: gelatin: polyvinyl alcohol (PVA): cross-linking sodium carboxymethyl cellulose (CMC-Na): polyvinylpyrrolidone (PVP): glycerol: zinc oxide is 0.3: 1.5: 2: 0.4: 1: 2.5: 8: 0.1 weight portion ratio, with arabic gum, gelatin, polyvinyl alcohol (PVA), mix homogeneously dissolved after polyvinylpyrrolidone (PVP) added an amount of water, after the adding zinc oxide stirs evenly, adding glycerol again stirs evenly, pour into and add cross-linking sodium carboxymethyl cellulose (CMC-Na) in the mortar and grind well, add volatile matter and Borneolum Syntheticum mixture, adding volatile oil behind the mix homogeneously fully grinds, at the last figure cloth of crust cloth cream coating instrument, naturally dry to moisture 30% o'clock epiphragma of mastic, promptly get the Chinese medicine patch unguentum that the present invention treats children's digestive system disease.
The embodiment of the invention 6: get Fructus Evodiae 3.5g, Fructus Piperis 4g, Cortex Cinnamomi 3.5g, Flos Caryophylli 4g, Rhizoma Atractylodis Macrocephalae 5g, Borneolum Syntheticum 2g; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, in extracting pressure is 15～20MP, temperature is 45～50 ℃, and flow is under the condition of 10～15kg/h, extracts its volatile oil with supercritical carbon dioxide extraction apparatus, it is mixed with the Fructus cinnamomi camphorae oil of 0.114g, get total volatile oil, add purified talc 15g, grind well by volatile oil 2ml, moistening filter paper filters and makes Aromatic water behind the adding distil water 1000ml, with 80～98% edible ethanol dissolving Borneolum Syntheticum, the filter paper that mixes with moistening with above-mentioned Aromatic water filters, and promptly gets the distillate medicinal water that the present invention treats children's digestive system disease.
The embodiment of the invention 7: get Fructus Evodiae 1g, Fructus Piperis 1g, Cortex Cinnamomi 1g, Flos Caryophylli 1g, Rhizoma Atractylodis Macrocephalae 1g, Borneolum Syntheticum 1g; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, the petroleum ether (boiling range is 30～60) that adds 4 times of weight is as solvent extraction, and dipping extracts 3 times, each 12 hours, filter, the gained extract volatilizes in 50 ℃ of water-baths, and the Fructus cinnamomi camphorae oil of above-mentioned extract and 0.038g is lumped together, and is standby; Edible ethanol dissolving Borneolum Syntheticum with 80～98%, mix with the mixture of Fructus cinnamomi camphorae oil with above-mentioned volatile oil, obtain mixture and Borneolum Syntheticum mixture, then according to mixture and Borneolum Syntheticum mixture: anhydrous lanolin lanolin wax sorbitan: ethoxylation sorbitol anhydride fatty acid fat: propyl p-hydroxybenzoate: deionized water: fatty acid: phenylpropanol: quaternary ammonium salt cationic emulsifying agent: methyl parahydroxybenzoate is 5: 4: 0.4: 3: 0.1: 83.9: 1: 2: 0.5: 0.1 weight portion ratio, mentioned component mix homogeneously post-heating to 75 ℃ is stirred to cooling, promptly obtains the middle Medicatedbath lotion that the present invention treats children's digestive system disease.
The embodiment of the invention 8: get Fructus Evodiae 1g, Fructus Piperis 2g, Cortex Cinnamomi 1g, Flos Caryophylli 2g, Rhizoma Atractylodis Macrocephalae 2g, Borneolum Syntheticum 0.5g; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, with add 3～5 times of weight, boiling ranges be 30～60 petroleum ether as solvent extraction, dipping extracts 1～3 time, each 8～24 hours, filter, the gained extract volatilizes in 40～60 ℃ of water-baths, and is standby; The Fructus cinnamomi camphorae oil of above-mentioned extract and 0.0038g is mixed, obtain mixture, edible ethanol dissolving Borneolum Syntheticum with 80～98%, mix with said mixture, obtain mixture and Borneolum Syntheticum mixture, then according to mixture and Borneolum Syntheticum mixture: arabic gum: gelatin: polyvinyl alcohol (PVA): cross-linking sodium carboxymethyl cellulose (CMC-Na): polyvinylpyrrolidone (PVP): glycerol: zinc oxide is 0.3: 1.5: 2: 0.4: 1: 2.5: 8: 0.1 weight portion ratio, with arabic gum, gelatin, polyvinyl alcohol (PVA), mix homogeneously dissolved after polyvinylpyrrolidone (PVP) added an amount of water, after the adding zinc oxide stirs evenly, adding glycerol again stirs evenly, pour into and add cross-linking sodium carboxymethyl cellulose (CMC-Na) in the mortar and grind well, add volatile matter and Borneolum Syntheticum mixture, adding volatile oil fully grinds behind the mix homogeneously, at the last figure cloth of crust cloth cream coating instrument, naturally dry to moisture 30% o'clock epiphragma of mastic, promptly get the Chinese medicine patch unguentum that the present invention treats children's digestive system disease.
The embodiment of the invention 9: get Fructus Evodiae 3.5g, Fructus Piperis 4g, Cortex Cinnamomi 3.5g, Flos Caryophylli 4g, Rhizoma Atractylodis Macrocephalae 5g; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, adds 3～5 times of weight, boiling ranges and be 30～60 petroleum ether as solvent extraction, and dipping extracts 1～3 time, and each 8～24 hours, filter, the gained extract volatilizes in 40～60 ℃ of water-baths, and is standby; The Fructus cinnamomi camphorae oil of above-mentioned extract and 0.0038g is mixed, obtain mixture, add an amount of purified talc then, grind well, filter with moistening filter paper after adding extraction water 1000ml, with mix with the dissolved Borneolum Syntheticum of 80～98% edible ethanol, promptly get the distillate medicinal water that the present invention treats children's digestive system disease.
Claims (8)
1. Chinese medicine preparation for the treatment of children's digestive system disease, it is characterized in that: calculate according to composition by weight, it is by 0.0038～0.114 part of Fructus cinnamomi camphorae oil, 1～3.5 part of Fructus Evodiae, 2～4 parts in Fructus Piperis, 1～3.5 part of Cortex Cinnamomi, 2～4 parts of Flos Caryophyllis, 2～5 parts of the Rhizoma Atractylodis Macrocephalaes, Borneolum Syntheticum is prepared from for 0.5～2 part.
2. according to the Chinese medicine preparation of the described treatment children's digestive system disease of claim 1, it is characterized in that: calculate according to weight, it is by Fructus cinnamomi camphorae oil 0.038g, Fructus Evodiae 1g, and Fructus Piperis 1g, Cortex Cinnamomi 1g, Flos Caryophylli 1g, Rhizoma Atractylodis Macrocephalae 1g, Borneolum Syntheticum 1g is prepared from.
3. the preparation method of the Chinese medicine preparation of treatment children's digestive system disease as claimed in claim 1 or 2 is characterized in that: get Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, is put in the volatile oil extractor, adds the water of 8～12 times of weight, extracts 8～10 hours, obtains Aromatic water and volatile oil, lumps together the Fructus cinnamomi camphorae oil of volatile oil and recipe quantity standby; Edible ethanol dissolving Borneolum Syntheticum with 80～98% mixes with the mixture of Fructus cinnamomi camphorae oil with above-mentioned Aromatic water or volatile oil, adds suitable adjuvant then, is prepared into required Chinese medicine preparation.
4. according to the preparation method of the Chinese medicine preparation of the described treatment children's digestive system disease of claim 3, it is characterized in that: get Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, is put in the volatile oil extractor, adds the water of 8～12 times of weight, extracts 8～10 hours, obtains Aromatic water and volatile oil, and the Fructus cinnamomi camphorae oil of volatile oil and recipe quantity is lumped together, and is standby; Edible ethanol dissolving Borneolum Syntheticum with 80～98%, mix with the mixture of Fructus cinnamomi camphorae oil with above-mentioned volatile oil, obtain volatile oil and Borneolum Syntheticum mixture, then according to volatile oil and Borneolum Syntheticum mixture: anhydrous lanolin lanolin wax sorbitan: ethoxylation sorbitol anhydride fatty acid fat: propyl p-hydroxybenzoate: deionized water: fatty acid: phenylpropanol: quaternary ammonium salt cationic emulsifying agent: methyl parahydroxybenzoate is 2～5: 2～4: 0.2～0.6: 1～4: 0.1～0.2: 91.4～81.9: 0.5～1.5: 1～2: 0.2～0.6: 0.1～0.2 weight portion ratio, mentioned component mix homogeneously post-heating to 75 ℃ is stirred to cooling, promptly obtains the middle Medicatedbath lotion that the present invention treats children's digestive system disease.
5. according to the preparation method of the Chinese medicine preparation of the described treatment children's digestive system disease of claim 3, it is characterized in that: get Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder,, be put in the volatile oil extractor, add the water of 8～12 times of weight, extracted 8～10 hours, obtain Aromatic water and volatile oil, volatile oil and Fructus cinnamomi camphorae oil are lumped together, standby; Edible ethanol dissolving Borneolum Syntheticum with 80～98%, mix with the mixture of Fructus cinnamomi camphorae oil with above-mentioned volatile oil, obtain volatile oil and Borneolum Syntheticum mixture, then according to volatile oil and Borneolum Syntheticum mixture: arabic gum: gelatin: polyvinyl alcohol: cross-linking sodium carboxymethyl cellulose: polyvinylpyrrolidone: glycerol: zinc oxide is 0.2～0.6: 0.5～3.5: 0.5～3.5: 0.2～3.5: 0.5～1.5: 0.6～4: 6～15: 0.1 weight portion ratio, with arabic gum, gelatin, polyvinyl alcohol, mix homogeneously dissolved after polyvinylpyrrolidone added an amount of water, after the adding zinc oxide stirs evenly, adding glycerol again stirs evenly, pour in the mortar and to add cross-linking sodium carboxymethyl cellulose and grind well, add volatile matter and Borneolum Syntheticum mixture, adding volatile oil behind the mix homogeneously fully grinds, at the last figure cloth of crust cloth cream coating instrument, naturally dry to moisture 30% o'clock epiphragma of mastic, promptly get the Chinese medicine patch unguentum that the present invention treats children's digestive system disease.
6. according to the preparation method of the Chinese medicine preparation of the described treatment children's digestive system disease of claim 3, it is characterized in that: get Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, is put in the volatile oil extractor, the water that adds 8～12 times of weight, extracted 8～10 hours, and obtained Aromatic water and volatile oil, use the filter paper of moistening to filter the Aromatic water that obtains, the Fructus cinnamomi camphorae oil of recipe quantity is added purified talc 15g by volatile oil 2ml, grind well, moistening filter paper filters and makes Aromatic water behind the adding distil water 1000ml, and two kinds of Aromatic water are lumped together; Edible ethanol dissolving Borneolum Syntheticum with 80～98% mixes with above-mentioned Aromatic water, and the filter paper filtration with moistening promptly gets the distillate medicinal water that the present invention treats children's digestive system disease.
7. treat the preparation method of the Chinese medicine preparation of children's digestive system disease as claimed in claim 1 or 2, it is characterized in that: get Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum, with Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, in extracting pressure is that 15～20MP, temperature are 45～50 ℃, flow is under the condition of 10～15kg/h, extracts its volatile oil with supercritical carbon dioxide extraction apparatus, and is standby; With 80～98% edible ethanol dissolving Borneolum Syntheticum, mix with above-mentioned volatile oil and Fructus cinnamomi camphorae oil, the total volatile oil that obtains and the mixture of Borneolum Syntheticum are added suitable adjuvant, are prepared into required Chinese medicine preparation.
8. the preparation method of the Chinese medicine preparation of treatment children's digestive system disease as claimed in claim 1 or 2 is characterized in that: get Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum; With Fructus Evodiae, Fructus Piperis, Cortex Cinnamomi, Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae is ground into coarse powder, adds 3～5 times of weight, boiling ranges and be 30～60 petroleum ether as solvent extraction, and dipping extracts 1～3 time, and each 8～24 hours, filter, the gained extract volatilizes in 40～60 ℃ of water-baths, and is standby; With 80～98% edible ethanol dissolving Borneolum Syntheticum, volatilize extract behind the solvent and the Fructus cinnamomi camphorae oil of recipe quantity mixes with above-mentioned, add suitable adjuvant then, be prepared into required Chinese medicine preparation.
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| CN104367662A (en) * | 2014-11-17 | 2015-02-25 | 铜仁职业技术学院 | Medicine for treating salmonellosis disease of chicks and preparation method of medicine |
| CN106581180A (en) * | 2017-02-24 | 2017-04-26 | 贵州金桥药业有限公司 | Traditional Chinese medicinal composition preparation for treating stomachaches, abdominal distension and diarrhea |
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| CN1069194A (en) * | 1991-08-03 | 1993-02-24 | 董学武 | The prescription and the processing technology of the safe and comfortable bag medicine core of child |
| CN1129595A (en) * | 1995-02-20 | 1996-08-28 | 刘杰利 | Multifunctional therapeutic and health-care equipment |
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| CN111567717A (en) * | 2020-05-27 | 2020-08-25 | 河南大学 | Chinese yam mucilage-nano zinc oxide solution and preparation method and application thereof |
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| CN116270489A (en) * | 2023-03-22 | 2023-06-23 | 遵义市中医院 | Ginger stomach-activating granule and preparation method thereof |
| CN116270489B (en) * | 2023-03-22 | 2023-09-08 | 遵义市中医院 | Ginger stomach-activating granule and preparation method thereof |
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