CN111939205A - Medicinal moxibustion for acute diarrhea and preparation method thereof - Google Patents
Medicinal moxibustion for acute diarrhea and preparation method thereof Download PDFInfo
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- CN111939205A CN111939205A CN202010813052.6A CN202010813052A CN111939205A CN 111939205 A CN111939205 A CN 111939205A CN 202010813052 A CN202010813052 A CN 202010813052A CN 111939205 A CN111939205 A CN 111939205A
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- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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Abstract
The invention discloses a medicinal moxibustion for acute diarrhea and a preparation method thereof, and relates to the technical field of medical treatment and health care, the medicinal moxibustion comprises a heating bag and a medicament patch, the medicament patch comprises a medicament bag and a medicament, the medicament comprises a medicament composition I and a medicament composition II, and the medicament composition I comprises the following components in parts by weight: 13-15 parts of fructus evodiae, 8-14 parts of cinnamon, 8-10 parts of clove, 12-14 parts of composite essential oil and 16-20 parts of ethosome matrix; the medicament composition II comprises the following components in parts by weight: 10-14 parts of nutmeg, 6-10 parts of pepper, 5-7 parts of folium artemisiae argyi, 4-8 parts of radix bupleuri and 18-22 parts of microemulsion matrix; the medicinal moxibustion for acute diarrhea can rapidly adjust water metabolism of human body, recover normal function, relieve and eliminate diarrhea symptoms, obviously shorten treatment course, has no toxic or side effect, no abnormal medicinal taste and low cost.
Description
Technical Field
The invention relates to the technical field of health care, in particular to a medicinal moxibustion for acute diarrhea and a preparation method thereof.
Background
Diarrhea refers to increased frequency of defecation, thin stools, or the presence of mucus, bloody pus or undigested food. If the excrement is drained more than 3 times a day, or the total amount of excrement exceeds 200g per day and the water content exceeds 80%, the diarrhea can be considered. Acute diarrhea is known as "acute diarrhea" when the disease course does not exceed 2 weeks; the disease course over 2 months is called chronic diarrhea.
Traditional moxibustion, such as moxa sticks and moxa sticks, is widely used for moxibustion to treat various diseases. However, in clinical use, a professional doctor is required to operate, and in the implementation process, the doctor is required to skillfully master the names, the positions, the moxibustion application sequence and the moxibustion application time of related acupuncture points of different diseases, particularly the moxibustion time is not easy to control, the operation is often inaccurate, the moxibustion effect is affected, and the treatment course is prolonged; after the moxa-moxibustion got into the family, in self-service use, numerous patients lacked professional knowledge and skill, not only the pertinence is not strong, leads to the curative effect relatively poor, and misoperation easily moreover, this can lead to the side effect, brings great loss for people.
Recently, drugs are added into moxibustion, moxibustion therapy is realized by means of moxibustion therapy process, and the defects of weak pertinence, simple drug formula, unreasonable compatibility and unobvious improvement of curative effect exist. The conventional method for treating diarrhea in the prior art can obtain curative effect on mild diarrhea, while children's sudden diarrhea, acute onset and rapid change can cause dehydration rapidly, and the conventional method cannot deal with the diarrhea in time and has poor curative effect.
In conclusion, a mild and stable moxibustion for acute diarrhea needs to be studied.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a medicinal moxibustion for acute diarrhea and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a medicinal moxibustion for acute diarrhea comprises a heating bag and a medicament patch, wherein the medicament patch comprises a medicament bag and a medicament, the medicament comprises a medicament composition I and a medicament composition II, and the raw materials of the medicament composition I comprise the following components in parts by weight: 13-15 parts of fructus evodiae, 8-14 parts of cinnamon, 8-10 parts of clove, 12-14 parts of composite essential oil and 16-20 parts of ethosome matrix; the medicament composition II comprises the following components in parts by weight: 10-14 parts of nutmeg, 6-10 parts of pepper, 5-7 parts of folium artemisiae argyi, 4-8 parts of radix bupleuri and 18-22 parts of microemulsion matrix.
Preferably, the ethosome matrix comprises 8-12 parts by weight of isopropanol, 8-12 parts by weight of ethanol, 4-5 parts by weight of hydroxypropyl methyl cellulose, 8-10 parts by weight of lecithin, 5-7 parts by weight of cholesterol, 6-8 parts by weight of hyaluronic acid, 10-14 parts by weight of glycerol and 14-16 parts by weight of sodium alginate.
Preferably, the microemulsion matrix comprises, by weight, 10-12 parts of oleic acid, 5-9 parts of propylene glycol, 4-8 parts of xanthan gum, 10-20 parts of polyoxyethylene castor oil, 8-10 parts of isopropyl myristate, 6-8 parts of citric acid and 16-20 parts of water.
Preferably, the heating bag comprises a material bag and a heating agent, wherein the heating agent comprises, by weight, 40-80 parts of iron powder, 10-30 parts of a water gel, 4-10 parts of an auxiliary dispersing agent, 10-20 parts of a catalyst and 5-10 parts of a coupling agent.
Preferably, the condensed hydrocolloid comprises the following components in parts by weight: 1-2 parts of high-molecular water-absorbing resin, 2-4 parts of salt and 10-20 parts of water.
Preferably, the high molecular water-absorbing resin is polyacrylic acid water-absorbing resin or PVA resin.
Preferably, the catalyst is a carbon compound, and the auxiliary dispersant is one or more of vermiculite, wood chips, floating beads and diatomite. The choice of catalyst can be adapted according to the prior art.
Preferably, the coupling agent comprises the following components in parts by weight: 1-2 parts of propylene glycol, 10-30 parts of vaseline, 10-20 parts of monoglyceride, 0.5-1 part of polyvinylpyrrolidone and 10-15 parts of lanolin.
Preferably, the heating bag and the medicament paste are mutually adhered; the medicament bag and the material bag are sewn by two layers of thin cloth, wherein one layer is composed of laminating non-woven fabric, and the other layer is composed of breathable film; one surface of the material bag, which is formed by the laminated non-woven fabric, is bonded with one surface of the medicament bag, which is formed by the laminated non-woven fabric; the medicament bag is equipped with the one side of ventilative film and sets up pressure-sensitive adhesive to the configuration is from type paper, the material area is equipped with the one side of ventilative film all around and is equipped with pressure-sensitive adhesive, and disposes from type paper.
Preferably, the preparation method of the pharmaceutical composition I comprises the following steps:
1) placing fructus evodiae, cortex Cinnamomi and flos Caryophylli into superfine jet mill, and pulverizing; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, and adding deionized water for extraction; filtering the Chinese medicinal liquid in the ultrasonic extractor to obtain nanometer Chinese medicinal ultrasonic extractive solution;
2) placing the ultrasonic extraction liquid of the nano traditional Chinese medicine into a vacuum high-speed dispersion tank, sequentially adding isopropanol, ethanol, hydroxypropyl methylcellulose, lecithin, cholesterol and hyaluronic acid, and uniformly dispersing to obtain a nano traditional Chinese medicine ethosome;
3) placing nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding composite essential oil, sodium alginate, glycerol and deionized water, and uniformly dispersing to obtain the pharmaceutical composition I.
Preferably, in the pulverizing process in the step 1) of preparing the pharmaceutical composition I, the medicine feeding speed is set to be 60 g/min, the pulverizing granularity is adjusted to be 30-40nm, and the traditional Chinese medicine is finely pulverized; in the extraction process, the dosage of deionized water is 6-8 times of the weight of the raw material medicine, and the extraction time is 30-40 min. The above range can be adaptively modified according to the weight of the Chinese medicinal materials to be treated, for example, the treatment time can be prolonged when the amount of the Chinese medicinal materials is large.
Preferably, in the step 2) of preparing the pharmaceutical composition I, the rotation speed of the dispersion tank is 3000 r/min, and the high-speed dispersion is carried out for 15 min. In the step 3) of preparing the pharmaceutical composition I, the rotation speed of the dispersion tank was adjusted to 1400 rpm, and the dispersion was carried out at a high speed for 20 minutes. The specific parameters can be adaptively adjusted according to actual conditions. Deionized water is added in the step 3), and the specific content can be adjusted adaptively according to the prior art of high-speed dispersion.
Preferably, the preparation method of the pharmaceutical composition II comprises the following steps:
1) pulverizing semen Myristicae, fructus Piperis and folium Artemisiae Argyi into fine powder to obtain medicinal mixture;
2) oil phase: mixing the medicine mixture, radix bupleuri, oleic acid, isopropyl myristate and polyoxyethylene castor oil in an ice water bath, and uniformly stirring for 20-50 min to form an oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in an ice-water bath for 10-50 min to form a water phase;
4) microemulsion polymerization: and mixing the oil phase and the water phase, heating to 70-90 ℃ under an oxygen-free condition, carrying out ultrasonic dispersion, mechanically stirring at a speed of 400-800 r/min, carrying out microemulsion polymerization for 3-7 h, and cooling to room temperature to obtain a medicament composition II.
Preferably, the preparation method of the medicinal moxibustion for acute diarrhea comprises the following steps:
1) preparation of the medicament patch: respectively preparing a medicament composition I and a medicament composition II, then uniformly mixing, and putting into a medicament bag to prepare a medicament patch;
2) preparing a heating bag:
A. weighing the macromolecular water-absorbing resin, the salt and the water according to the proportion, and uniformly mixing to obtain a water gel;
B. weighing propylene glycol, vaseline, monoglyceride, polyvinylpyrrolidone and lanolin according to a ratio, and uniformly mixing to obtain a coupling agent;
C. weighing iron powder, water gel, auxiliary dispersant, catalyst and coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3) and (3) mutually bonding the medicament patch prepared in the step 1) and the heating bag prepared in the step 2) to prepare the medicinal moxibustion for acute diarrhea.
The fructus evodiae is dry and nearly mature fruit of Rutaceae plant fructus evodiae or Rutaceae plant fructus evodiae. Pungent, bitter and hot in nature; has little toxicity. It enters liver, spleen, stomach and kidney meridians. The functional indications are as follows: dispel cold and alleviate pain, check adverse rise of qi and arrest vomiting, strengthen yang and check diarrhea. Can be used for treating syncope headache, cold hernia abdominal pain, cold dampness loempe, menstrual abdominal pain, emesis, acid regurgitation, morning diarrhea, and aphtha; hypertension is caused.
Cinnamon is the dried bark of cinnamon belonging to the family Lauraceae. Pungent and sweet in nature and flavor and big heat. It enters kidney, spleen, heart and liver meridians. The functional indications are as follows: tonify fire and strengthen yang, guide fire to the origin, dispel cold and alleviate pain, activate blood and dredge channels. Can be used for treating sexual impotence, cold womb, psychroalgia of waist and knee, asthma due to kidney deficiency, vertigo due to yang deficiency, conjunctival congestion, pharyngalgia, psychroalgia of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, galloping, amenorrhea, and dysmenorrhea.
Flos Caryophylli is the dried bud of flos Caryophylli of Myrtaceae. Pungent and warm in nature and flavor. It enters spleen, stomach, lung and kidney meridians. The functional indications are as follows: to warm the middle-jiao and descend the adverse flow of qi, tonify the kidney and strengthen yang. Can be used for treating deficiency-cold of spleen and stomach, singultus emesis, anorexia vomiting and diarrhea, psychroalgia of heart and abdomen, and sexual impotence due to kidney deficiency.
Tea tree essential oil: the extract of Camellia sinensis has antibacterial, antiinflammatory, pore astringing, common cold, cough, rhinitis, asthma treating, dysmenorrhea improving, menoxenia and genital infection improving effects.
Lemon essential oil: has effects in improving circulatory system function, enhancing immune system, cleaning body, improving digestive system function, and treating dyspepsia and constipation.
Lavender essential oil: is extracted from Lavender, and has effects of relieving pressure and relaxing muscle.
The semen Myristicae is dried kernel of Myristica fragrans Houtt belonging to family Myristicaceae, genus Myristica. Pungent and warm in nature and flavor. It enters spleen, stomach and large intestine meridians. The functional indications are as follows: warm middle energizer and move qi, astringe intestines to check diarrhea. Can be used for treating deficiency-cold of spleen and stomach, chronic diarrhea, abdominal distention and pain, anorexia, and emesis.
Pepper is a dry, near-ripe or ripe fruit of pepper of the family Piperaceae. Pungent in flavor and hot in nature. It enters stomach and large intestine meridians. The functional indications are as follows: warm middle energizer and dispel cold, descend qi, resolve phlegm. Can be used for treating stomach cold emesis, abdominal pain diarrhea, anorexia, epilepsy and excessive phlegm.
The folium Artemisiae Argyi is dried leaf of Artemisia argyi of Compositae. Pungent, bitter and warm in nature; has little toxicity. It enters liver, spleen and kidney meridians. The functional indications are as follows: dispel cold to alleviate pain, warm meridians to stop bleeding. Can be used for treating lower abdomen psychroalgia, irregular menstruation, infertility due to cold womb, hematemesis, epistaxis, metrorrhagia, metrostaxis, and pregnancy bleeding; it can be used for treating skin pruritus. Vinegar moxa charcoal warms the channels to stop bleeding. Can be used for treating hemorrhage due to deficiency cold.
The bupleuri radix is dried root of Bupleurum scorzonerifolium or Bupleurum scorzonerifolium of Umbelliferae. Bitter in property and slightly cold in nature. It enters liver and gallbladder meridians. The functional indications are as follows: harmonize exterior and interior, soothe liver and raise yang. Can be used for treating common cold, fever, alternating chills and fever, distending pain in chest and hypochondrium, menoxenia, prolapse of son and sense organs, and proctoptosis.
According to the analysis of the chemical beneficial components of the traditional Chinese medicines, the evodia rutaecarpa, the cinnamon, the clove, the compound essential oil, the nutmeg, the pepper and the folium artemisiae argyi all belong to warm-tonifying type traditional Chinese medicines, and have the effects of reinforcing qi and warming and tonifying kidney yang. The traditional Chinese medicinal materials of the scheme have reasonable compatibility of monarch, minister, assistant and guide, obvious effect, low cost and obvious effect, promote blood circulation, warm and tonify kidney yang, and are matched with acupuncture point-specific moxibustion.
From the functional analysis, the scheme prepares the ethosome through compound essential oil and traditional Chinese medicine carrier, effectively utilizes the synergistic effect of the ethosome and moxibustion thermotherapy to improve the permeation effect of the medicine components, and particularly when the ethosome is in the environment with the membrane phase transition temperature higher than, the local high temperature strengthens the motion of phospholipid molecules, the structure of liposome membrane changes, and the regularly and compactly arranged colloid crystalline state phospholipid bilayers become loose and disordered liquid crystal states at higher temperature, so that the medicine is released, thereby achieving the effects of improving the curative effect, reducing the toxic and side effects and enhancing the targeting property.
Simultaneously, this scheme utilizes medicine moxibustion can release heat and rapid heating up's characteristics when using, add compound essential oil in the ethosome. On one hand, the medicinal moxibustion device can automatically adjust volatilization and release of different components of essential oil (namely tea tree essential oil, lemon essential oil and lavender essential oil) according to the temperature during temperature rise, so that the effect that each component of essential oil acts on a patient in sequence is achieved; on the other hand, when the temperature rises too fast, the volatilization of each component essential oil can take away a part of body surface heat, has reached effective control service temperature to avoid the high temperature to bring the effect of discomfort or injury for the patient.
In addition, isopropanol, ethanol, hydroxypropyl methylcellulose, hyaluronic acid and a microemulsion matrix are added, and the drug is carried by the ethosome and the microemulsion, so that the absorption efficiency of the drug is improved. The transdermal drug delivery system is an effective administration mode for absorbing therapeutic drugs through the skin, and the therapeutic drugs are applied to the skin, penetrate through the stratum corneum of the skin, diffuse into each layer of the skin, and then are absorbed into the systemic circulation by the capillaries in the skin tissue. The whole preparation process of the ethosome can be finished at normal temperature, can encapsulate the medicament, and can achieve higher encapsulation efficiency. The ethosome containing the traditional Chinese medicine has the characteristics of deformability, good fluidity, small skin irritation, good transdermal effect, large skin retention, capability of transferring the medicine in cells and the like. The microemulsion containing the drug is used as a carrier of a transdermal drug delivery preparation, and the transdermal effect of the drug is remarkable. The mechanism is as follows: 1. increasing the solubility of the drug; 2. altering the structure of the stratum corneum; 3. passing through the hair follicle in an intact structure; 4. the medicine can penetrate skin after being precipitated from microemulsion.
Compared with the prior art, the invention provides a medicinal moxibustion for acute diarrhea and a preparation method thereof, and the medicinal moxibustion has the following beneficial effects:
1. the medicinal moxibustion for acute diarrhea can rapidly adjust water metabolism of human body, recover normal function, relieve and eliminate diarrhea symptoms, obviously shorten treatment course, has no toxic or side effect, no abnormal medicinal taste and low cost. According to the invention, the traditional Chinese medicine formula is screened by adopting the theory of treatment based on syndrome differentiation according to the traditional Chinese medicine theory, the formula is scientific and reasonable, the preparation is simple, no toxic or side effect is caused, the curative effect is short, the effect is quick, the qi and blood circulation are promoted, and finally the spleen and the stomach are nourished for the spleen and the stomach of a patient, and the whole formula has the effects of promoting the circulation of qi and the blood, and strengthening the spleen and the stomach.
2. The alcohol liposome contains ethanol in liposome, phospholipid is the main chemical component in the bilayer structure of the alcohol liposome, and the alcohol liposome contains relatively high volume fraction of ethanol, i.e. high concentration of low molecular weight alcohol is added on the basis of the liposome. The existence of ethanol enhances the flexibility of the liposome, and after the low molecular weight alcohol is added, the ethanol replaces the moisture near the head group of the lipid bilayer, thereby increasing and improving the mobility of the bilayer, and the ethanol molecule also changes the close arrangement of phospholipid molecules between skin cutin layers, promotes the drug to permeate skin barriers, and improves the transdermal absorption effect.
The ethosome can be fused with the cell membrane of the organism, and the wrapped content is transferred into the cell membrane; ethosomes are easily deformed to penetrate the various pores of the skin barrier, such as the phospholipid layer between the cuticles and the pilosebaceous glands, etc.; the ethosome is a zwitterionic surfactant, has oleophilic and hydrophilic properties, and can effectively encapsulate various compounds (fat-soluble and water-soluble molecules including protein polypeptide molecules) to penetrate to reach the deep layer of the skin. Therefore, it can be said that the flexible liposome and the ethosome have increased membrane flexibility, have increased deformability when crossing the skin barrier, are more suitable for crossing the keratinocyte gap, and are ideal carriers for carrying macromolecules.
3. The microemulsion has the characteristics of low viscosity, isotropy and thermodynamic stability, and is a transparent or semitransparent oil-water mixed system. The microemulsion can increase the solubility of the drug, increase the transdermal rate of the drug, improve the stability of the drug, prolong the action time of the drug, maintain constant blood concentration, and has simple preparation process and the like.
4. According to the scheme, two methods of the ethosome and the microemulsion for promoting the skin to absorb the drug are adopted, so that the absorption efficiency of the drug is further improved, the effect is fast, the pertinence is strong, and the treatment effect is good.
5. The coupling agent is creatively added into the gel heating agent, has the functions of coupling, conduction and permeation, so that the product is more closely contacted with the skin, the energy is efficiently and uniformly absorbed by the skin and tissues, the synergistic effects of coupling, conduction and permeation are achieved, the treatment speed is accelerated, the effect is quick, and the defects that the patch on the market generally adopts the traditional process and the simple skin permeation and absorption principle are overcome.
6. The heating bag can locally heat the affected part, dilate capillary vessels, and accelerate blood circulation and tissue metabolism; the couplant is applied, so that energy is efficiently and uniformly absorbed by skin and tissues, and the couplant has the effects of coupling, conduction and permeation; acting on skin and subcutaneous tissue, promoting molecular movement in cells, accelerating metabolism, promoting drug absorption, rapidly transporting to affected part, and improving rapid therapeutic effect.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Example 1:
a medicinal moxibustion for acute diarrhea and its preparation method comprise the following steps:
1. preparation of the medicament patch:
the preparation method of the A medicament composition I comprises the following steps:
1) weighing 13 parts of fructus evodiae, 8 parts of cinnamon, 8 parts of clove, 12 parts of composite essential oil and 16 parts of ethosome matrix according to the proportion; placing fructus evodiae, cortex Cinnamomi and flos Caryophylli into an ultra-fine jet mill, pulverizing at a feed rate of 60 g/min, and adjusting the pulverizing particle size to 30 nm; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, adding deionized water for extraction, wherein the dosage of the deionized water is 6 times of the weight of the raw material medicines, and the extraction time is 30 min; filtering the Chinese medicinal liquid in the ultrasonic extractor to obtain nanometer Chinese medicinal ultrasonic extractive solution;
2) placing the nano traditional Chinese medicine ultrasonic extraction liquid into a vacuum high-speed dispersion tank, sequentially adding 8 parts of isopropanol, 8 parts of ethanol, 4 parts of hydroxypropyl methyl cellulose, 8 parts of lecithin, 5 parts of cholesterol and 6 parts of hyaluronic acid, and uniformly dispersing to form a nano traditional Chinese medicine ethosome, wherein the rotating speed of the dispersion tank is 3000 r/min, and the high-speed dispersion is carried out for 15 min;
3) placing the nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding 12 parts of compound essential oil, 10 parts of glycerol, 14 parts of sodium alginate and 800 parts of deionized water, uniformly dispersing to obtain a medicament composition I, adjusting the rotating speed of the dispersion tank to 1400 revolutions per minute, and dispersing at a high speed for 20 minutes;
the preparation method of the B medicament composition II comprises the following steps:
1) weighing 10 parts of nutmeg, 6 parts of pepper, 5 parts of folium artemisiae argyi, 4 parts of radix bupleuri and 18 parts of microemulsion matrix according to the proportion, and crushing the nutmeg, the pepper and the folium artemisiae argyi into fine powder to prepare a medicine mixture;
2) oil phase: weighing 10 parts of oleic acid, 5 parts of propylene glycol, 4 parts of xanthan gum, 10 parts of polyoxyethylene castor oil, 8 parts of isopropyl myristate, 6 parts of citric acid and 16 parts of water according to a ratio; mixing the medicinal mixture, bupleuri radix, oleic acid, isopropyl myristate and polyoxyethylene castor oil in ice water bath, and stirring for 20min to obtain oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in ice water bath for 10min to obtain water phase;
4) microemulsion polymerization: mixing the oil phase and the water phase, heating to 70 ℃ under an oxygen-free condition, carrying out ultrasonic dispersion, mechanically stirring at the speed of 400 r/min, carrying out microemulsion polymerization for 3h, and then cooling to room temperature to obtain a medicament composition II;
and C, uniformly mixing the prepared medicament composition I and the prepared medicament composition II, and putting the mixture into a medicament bag to prepare the medicament patch.
2. Preparing a heating bag:
A. weighing 1 part of high-molecular water-absorbing resin, 2 parts of salt and 10 parts of water according to the proportion, and uniformly mixing to obtain a water-gel;
B. weighing 1 part of propylene glycol, 10 parts of vaseline, 10 parts of monoglyceride, 0.5 part of polyvinylpyrrolidone and 10 parts of lanolin according to the proportion, and uniformly mixing to obtain a coupling agent;
C. weighing 40 parts of iron powder, 10 parts of water gel, 10 parts of auxiliary dispersing agent, 10 parts of catalyst and 5 parts of coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3. and (3) mutually bonding the medicament patch prepared in the step (1) and the heating bag prepared in the step (2) to prepare the medicinal moxibustion for acute diarrhea.
Example 2:
a medicinal moxibustion for acute diarrhea and its preparation method comprise the following steps:
1. preparation of the medicament patch:
the preparation method of the A medicament composition I comprises the following steps:
1) weighing 15 parts of fructus evodiae, 14 parts of cinnamon, 10 parts of clove, 14 parts of compound essential oil and 20 parts of ethosome matrix according to the proportion; placing fructus evodiae, cortex Cinnamomi and flos Caryophylli into an ultra-fine jet mill, pulverizing at a feed rate of 60 g/min, and adjusting the pulverizing particle size to 40 nm; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, adding deionized water for extraction, wherein the dosage of the deionized water is 8 times of the weight of the raw material medicines, and the extraction time is 40 min; filtering the Chinese medicinal liquid in the ultrasonic extractor to obtain nanometer Chinese medicinal ultrasonic extractive solution;
2) placing the nano traditional Chinese medicine ultrasonic extraction liquid into a vacuum high-speed dispersion tank, sequentially adding 12 parts of isopropanol, 12 parts of ethanol, 5 parts of hydroxypropyl methyl cellulose, 10 parts of lecithin, 7 parts of cholesterol and 8 parts of hyaluronic acid, and uniformly dispersing to form a nano traditional Chinese medicine ethosome, wherein the rotating speed of the dispersion tank is 3000 r/min, and the high-speed dispersion is carried out for 15 min;
3) placing the nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding 14 parts of compound essential oil, 14 parts of glycerol, 16 parts of sodium alginate and 800 parts of deionized water, uniformly dispersing to obtain a medicament composition I, adjusting the rotating speed of the dispersion tank to 1400 revolutions per minute, and dispersing at a high speed for 20 minutes;
the preparation method of the B medicament composition II comprises the following steps:
1) weighing 14 parts of nutmeg, 10 parts of pepper, 7 parts of folium artemisiae argyi, 8 parts of radix bupleuri and 22 parts of microemulsion matrix according to the proportion, and crushing the nutmeg, the pepper and the folium artemisiae argyi into fine powder to prepare a medicine mixture;
2) oil phase: weighing 12 parts of oleic acid, 9 parts of propylene glycol, 8 parts of xanthan gum, 20 parts of polyoxyethylene castor oil, 10 parts of isopropyl myristate, 8 parts of citric acid and 20 parts of water according to a ratio; mixing the medicinal mixture, bupleuri radix, oleic acid, isopropyl myristate and polyoxyethylene castor oil in ice water bath, and stirring for 50min to obtain oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in ice water bath for 50min to obtain water phase;
4) microemulsion polymerization: mixing the oil phase and the water phase, heating to 90 ℃ under an oxygen-free condition, performing ultrasonic dispersion, mechanically stirring at the speed of 800 r/min, performing microemulsion polymerization for 7h, and cooling to room temperature to obtain a medicament composition II;
and C, uniformly mixing the prepared medicament composition I and the prepared medicament composition II, and putting the mixture into a medicament bag to prepare the medicament patch.
2. Preparing a heating bag:
A. weighing 2 parts of high-molecular water-absorbing resin, 4 parts of salt and 20 parts of water according to the proportion, and uniformly mixing to obtain a water-gel;
B. weighing 2 parts of propylene glycol, 30 parts of vaseline, 20 parts of monoglyceride, 1 part of polyvinylpyrrolidone and 15 parts of lanolin according to a ratio, and uniformly mixing to obtain a coupling agent;
C. weighing 80 parts of iron powder, 30 parts of water gel, 30 parts of auxiliary dispersant, 20 parts of catalyst and 10 parts of coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3. and (3) mutually bonding the medicament patch prepared in the step (1) and the heating bag prepared in the step (2) to prepare the medicinal moxibustion for acute diarrhea.
Example 3:
a medicinal moxibustion for acute diarrhea and its preparation method comprise the following steps:
1. preparation of the medicament patch:
the preparation method of the A medicament composition I comprises the following steps:
1) weighing 14 parts of fructus evodiae, 11 parts of cinnamon, 9 parts of clove, 13 parts of composite essential oil and 18 parts of ethosome matrix according to the proportion; placing fructus evodiae, cortex Cinnamomi and flos Caryophylli into an ultra-fine jet mill, pulverizing at a feed rate of 60 g/min, and adjusting the pulverizing particle size to 35 nm; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, adding deionized water for extraction, wherein the dosage of the deionized water is 7 times of the weight of the raw material medicines, and the extraction time is 35 min; filtering the Chinese medicinal liquid in the ultrasonic extractor to obtain nanometer Chinese medicinal ultrasonic extractive solution;
2) placing the nano traditional Chinese medicine ultrasonic extraction liquid into a vacuum high-speed dispersion tank, sequentially adding 10 parts of isopropanol, 10 parts of ethanol, 4 parts of hydroxypropyl methyl cellulose, 9 parts of lecithin, 6 parts of cholesterol and 9 parts of hyaluronic acid, and uniformly dispersing to form a nano traditional Chinese medicine ethosome, wherein the rotating speed of the dispersion tank is 3000 r/min, and the high-speed dispersion is carried out for 15 min;
3) placing the nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding 13 parts of compound essential oil, 12 parts of glycerol, 15 parts of sodium alginate and 800 parts of deionized water, uniformly dispersing to obtain a medicament composition I, adjusting the rotating speed of the dispersion tank to 1400 revolutions per minute, and dispersing at a high speed for 20 minutes;
the preparation method of the B medicament composition II comprises the following steps:
1) weighing 12 parts of nutmeg, 8 parts of pepper, 6 parts of folium artemisiae argyi, 6 parts of radix bupleuri and 20 parts of microemulsion matrix according to the proportion, and crushing the nutmeg, the pepper and the folium artemisiae argyi into fine powder to prepare a medicine mixture;
2) oil phase: weighing 11 parts of oleic acid, 7 parts of propylene glycol, 6 parts of xanthan gum, 15 parts of polyoxyethylene castor oil, 9 parts of isopropyl myristate, 7 parts of citric acid and 18 parts of water according to a ratio; mixing the medicinal mixture, bupleuri radix, oleic acid, isopropyl myristate and polyoxyethylene castor oil in ice water bath, and stirring for 35min to obtain oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in ice water bath for 30min to obtain water phase;
4) microemulsion polymerization: mixing the oil phase and the water phase, heating to 80 ℃ under an oxygen-free condition, performing ultrasonic dispersion, mechanically stirring at a speed of 600 revolutions per minute, performing microemulsion polymerization for 5 hours, and cooling to room temperature to obtain a medicament composition II;
and C, uniformly mixing the prepared medicament composition I and the prepared medicament composition II, and putting the mixture into a medicament bag to prepare the medicament patch.
2. Preparing a heating bag:
A. weighing 1.5 parts of high molecular water-absorbing resin, 3 parts of salt and 15 parts of water according to the proportion, and uniformly mixing to obtain a water-gel;
B. weighing 1.5 parts of propylene glycol, 20 parts of vaseline, 15 parts of monoglyceride, 0.75 part of polyvinylpyrrolidone and 12.5 parts of lanolin according to the proportion, and uniformly mixing to obtain a coupling agent;
C. weighing 60 parts of iron powder, 20 parts of water gel, 20 parts of auxiliary dispersing agent, 15 parts of catalyst and 7.5 parts of coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3. and (3) mutually bonding the medicament patch prepared in the step (1) and the heating bag prepared in the step (2) to prepare the medicinal moxibustion for acute diarrhea.
Example 4:
a medicinal moxibustion for acute diarrhea and its preparation method comprise the following steps:
1. preparation of the medicament patch:
the preparation method of the A medicament composition I comprises the following steps:
1) weighing 13 parts of fructus evodiae, 14 parts of cinnamon, 8 parts of clove, 14 parts of compound essential oil and 18 parts of ethosome matrix according to the proportion; placing fructus evodiae, cortex Cinnamomi and flos Caryophylli into an ultra-fine jet mill, pulverizing at a feed rate of 60 g/min, and adjusting the pulverizing particle size to 33 nm; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, adding deionized water for extraction, wherein the dosage of the deionized water is 6 times of the weight of the raw material medicines, and the extraction time is 35 min; filtering the Chinese medicinal liquid in the ultrasonic extractor to obtain nanometer Chinese medicinal ultrasonic extractive solution;
2) placing the nano traditional Chinese medicine ultrasonic extraction liquid into a vacuum high-speed dispersion tank, sequentially adding 9 parts of isopropanol, 11 parts of ethanol, 4 parts of hydroxypropyl methyl cellulose, 10 parts of lecithin, 5 parts of cholesterol and 8 parts of hyaluronic acid, and uniformly dispersing to form a nano traditional Chinese medicine ethosome, wherein the rotating speed of the dispersion tank is 3000 r/min, and the high-speed dispersion is carried out for 15 min;
3) placing the nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding 12 parts of glycerol, 15 parts of sodium alginate and 800 parts of deionized water, uniformly dispersing to obtain a medicament composition I, adjusting the rotating speed of the dispersion tank to 1400 revolutions per minute, and dispersing at a high speed for 20 minutes;
the preparation method of the B medicament composition II comprises the following steps:
1) weighing 10 parts of nutmeg, 10 parts of pepper, 5 parts of folium artemisiae argyi, 8 parts of radix bupleuri and 20 parts of microemulsion matrix according to the proportion, and crushing the nutmeg, the pepper and the folium artemisiae argyi into fine powder to prepare a medicine mixture;
2) oil phase: weighing 11 parts of oleic acid, 6 parts of propylene glycol, 5 parts of xanthan gum, 12 parts of polyoxyethylene castor oil, 8 parts of isopropyl myristate, 6 parts of citric acid and 18 parts of water according to a ratio; mixing the medicinal mixture, bupleuri radix, oleic acid, isopropyl myristate and polyoxyethylene castor oil in ice water bath, and stirring for 30min to obtain oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in ice water bath for 20min to obtain water phase;
4) microemulsion polymerization: mixing the oil phase and the water phase, heating to 75 ℃ under an oxygen-free condition, performing ultrasonic dispersion, mechanically stirring at the speed of 500 r/min, performing microemulsion polymerization for 4 hours, and cooling to room temperature to obtain a medicament composition II;
and C, uniformly mixing the prepared medicament composition I and the prepared medicament composition II, and putting the mixture into a medicament bag to prepare the medicament patch.
2. Preparing a heating bag:
A. weighing 1.2 parts of high-molecular water-absorbing resin, 2.3 parts of salt and 12 parts of water according to the proportion, and uniformly mixing to obtain a water-gel;
B. weighing 1.2 parts of propylene glycol, 15 parts of vaseline, 12 parts of monoglyceride, 0.7 part of polyvinylpyrrolidone and 12 parts of lanolin according to the proportion, and uniformly mixing to obtain a coupling agent;
C. weighing 50 parts of iron powder, 16 parts of water gel, 15 parts of auxiliary dispersant, 13 parts of catalyst and 6 parts of coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3. and (3) mutually bonding the medicament patch prepared in the step (1) and the heating bag prepared in the step (2) to prepare the medicinal moxibustion for acute diarrhea.
Example 5:
a medicinal moxibustion for acute diarrhea and its preparation method comprise the following steps:
1. preparation of the medicament patch:
the preparation method of the A medicament composition I comprises the following steps:
1) weighing 15 parts of fructus evodiae, 8 parts of cinnamon, 10 parts of clove, 12 parts of compound essential oil and 18 parts of ethosome matrix according to the proportion; placing fructus evodiae, cortex Cinnamomi and flos Caryophylli into an ultra-fine jet mill, pulverizing at a feed rate of 60 g/min, and adjusting the pulverizing particle size to 37 nm; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, adding deionized water for extraction, wherein the dosage of the deionized water is 8 times of the weight of the raw material medicines, and the extraction time is 38 min; filtering the Chinese medicinal liquid in the ultrasonic extractor to obtain nanometer Chinese medicinal ultrasonic extractive solution;
2) placing the nano traditional Chinese medicine ultrasonic extraction liquid into a vacuum high-speed dispersion tank, sequentially adding 11 parts of isopropanol, 9 parts of ethanol, 5 parts of hydroxypropyl methyl cellulose, 8 parts of lecithin, 7 parts of cholesterol and 6 parts of hyaluronic acid, and uniformly dispersing to form a nano traditional Chinese medicine ethosome, wherein the rotating speed of the dispersion tank is 3000 r/min, and the high-speed dispersion is carried out for 15 min;
3) placing the nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding 12 parts of compound essential oil, 14 parts of glycerol, 14 parts of sodium alginate and 800 parts of deionized water, uniformly dispersing to obtain a medicament composition I, adjusting the rotating speed of the dispersion tank to 1400 revolutions per minute, and dispersing at a high speed for 20 minutes;
the preparation method of the B medicament composition II comprises the following steps:
1) weighing 14 parts of nutmeg, 6 parts of pepper, 7 parts of folium artemisiae argyi, 4 parts of radix bupleuri and 19 parts of microemulsion matrix according to the proportion, and crushing the nutmeg, the pepper and the folium artemisiae argyi into fine powder to prepare a medicine mixture;
2) oil phase: weighing 12 parts of oleic acid, 5 parts of propylene glycol, 8 parts of xanthan gum, 16 parts of polyoxyethylene castor oil, 10 parts of isopropyl myristate, 6 parts of citric acid and 19 parts of water according to a ratio; mixing the medicinal mixture, bupleuri radix, oleic acid, isopropyl myristate and polyoxyethylene castor oil in ice water bath, and stirring for 40min to obtain oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in ice water bath for 40min to obtain water phase;
4) microemulsion polymerization: mixing the oil phase and the water phase, heating to 80 ℃ under an oxygen-free condition, carrying out ultrasonic dispersion, mechanically stirring at the speed of 700 r/min, carrying out microemulsion polymerization for 6h, and then cooling to room temperature to obtain a medicament composition II;
and C, uniformly mixing the prepared medicament composition I and the prepared medicament composition II, and putting the mixture into a medicament bag to prepare the medicament patch.
2. Preparing a heating bag:
A. weighing 1.8 parts of high-molecular water-absorbing resin, 3.5 parts of salt and 18 parts of water according to the proportion, and uniformly mixing to obtain a water-gel;
B. weighing 1.7 parts of propylene glycol 27 parts of vaseline, 18 parts of monoglyceride, 0.8 part of polyvinylpyrrolidone and 13 parts of lanolin according to the proportion, and uniformly mixing to obtain a coupling agent;
C. weighing 70 parts of iron powder, 25 parts of water gel, 25 parts of auxiliary dispersant, 17 parts of catalyst and 9 parts of coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3. and (3) mutually bonding the medicament patch prepared in the step (1) and the heating bag prepared in the step (2) to prepare the medicinal moxibustion for acute diarrhea.
Comparative example 1:
in the medicament composition I in the comparative example 1, no ethosome matrix is added, and the Chinese medicinal raw materials are simply mixed; the rest of the steps are consistent with example 1.
Comparative example 2:
the microemulsion matrix is not added in the medicament composition II in the comparative example 2, and the traditional Chinese medicine raw materials are simply mixed; the rest of the steps are consistent with example 1.
Comparative example 3:
in the medicament composition I in the comparative example 3, the ethosome matrix and the compound essential oil are not added, and the microemulsion matrix is not added in the medicament composition II, so that the Chinese medicinal raw materials are simply mixed; the rest of the steps are consistent with example 1.
Experimental tests were conducted on the prepared moxibustion for acute diarrhea according to examples 1 to 5 and comparative examples 1 to 3, and the test subjects were 30 patients having symptoms per group. The therapeutic effect judgment refers to the therapeutic effect judgment standard formulated from the clinical disease diagnosis treatment improvement standard and the traditional Chinese medicine disease diagnosis therapeutic effect standard, and the therapeutic effect judgment is carried out according to the therapeutic effect index and the clinical diagnosis result.
a) And (3) healing: after 2 treatment courses, the discomfort symptoms disappear;
b) the effect is shown: after 2 treatment courses, the discomfort symptoms are obviously relieved;
c) the method has the following advantages: after 2 treatment courses, the discomfort symptoms are relieved to a certain extent;
d) and (4) invalidation: after 2 treatment courses, the discomfort symptoms have no links and even worsen.
The results are shown in table 1 below:
referring to the above examples 1 to 5, it can be seen from the experimental data of comparative examples 1 to 3 and table 1 that the moxibustion for acute diarrhea according to the present invention can rapidly adjust the water metabolism of the human body, restore the normal function, alleviate and eliminate the symptoms of diarrhea, significantly shorten the treatment period, and has no toxic or side effects, no abnormal medical odor, and low cost, compared to comparative examples 1 to 3. According to the invention, the traditional Chinese medicine formula is screened by adopting the theory of treatment based on syndrome differentiation according to the traditional Chinese medicine theory, the formula is scientific and reasonable, the preparation is simple, no toxic or side effect is caused, the curative effect is short, the effect is quick, the qi and blood circulation are promoted, and finally the spleen and the stomach are nourished for the spleen and the stomach of a patient, and the whole formula has the effects of promoting the circulation of qi and the blood, and strengthening the spleen and the stomach.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (10)
1. The medicinal moxibustion for acute diarrhea is characterized by comprising a heating bag and a medicament patch, wherein the medicament patch comprises a medicament bag and a medicament, the medicament comprises a medicament composition I and a medicament composition II, and the raw materials of the medicament composition I comprise the following components in parts by weight: 13-15 parts of fructus evodiae, 8-14 parts of cinnamon, 8-10 parts of clove, 12-14 parts of composite essential oil and 16-20 parts of ethosome matrix; the medicament composition II comprises the following components in parts by weight: 10-14 parts of nutmeg, 6-10 parts of pepper, 5-7 parts of folium artemisiae argyi, 4-8 parts of radix bupleuri and 18-22 parts of microemulsion matrix.
2. The medicated moxibustion for acute diarrhea according to claim 1, characterized in that the ethosome matrix comprises 8-12 parts by weight of isopropanol, 8-12 parts by weight of ethanol, 4-5 parts by weight of hydroxypropyl methylcellulose, 8-10 parts by weight of lecithin, 5-7 parts by weight of cholesterol, 6-8 parts by weight of hyaluronic acid, 10-14 parts by weight of glycerol and 14-16 parts by weight of sodium alginate.
3. A medicated moxibustion for acute diarrhea according to claim 1, characterized in that the microemulsion matrix comprises, by weight, 10-12 parts of oleic acid, 5-9 parts of propylene glycol, 4-8 parts of xanthan gum, 10-20 parts of polyoxyethylene castor oil, 8-10 parts of isopropyl myristate, 6-8 parts of citric acid and 16-20 parts of water.
4. The medicated moxibustion for acute diarrhea according to claim 1, wherein the compound essential oil comprises 1-3 parts of tea tree essential oil, 2-3 parts of lemon essential oil and 1-2 parts of lavender essential oil.
5. A medicated moxibustion for acute diarrhea according to claim 1, characterized in that the heating bag comprises a material bag and a heating agent, and the heating agent comprises the following components, by weight, 40-80 parts of iron powder, 10-30 parts of water gel, 4-10 parts of auxiliary dispersant, 10-20 parts of catalyst, and 5-10 parts of coupling agent.
6. The medicated moxibustion for acute diarrhea according to claim 5, wherein the hydrocolloid comprises the following components in parts by weight: 1-2 parts of high-molecular water-absorbing resin, 2-4 parts of salt and 10-20 parts of water; the high-molecular water-absorbing resin is polyacrylic acid water-absorbing resin or PVA resin.
7. The moxibustion for acute diarrhea according to claim 6, wherein the coupling agent comprises the following components in parts by weight: 1-2 parts of propylene glycol, 10-30 parts of vaseline, 10-20 parts of monoglyceride, 0.5-1 part of polyvinylpyrrolidone and 10-15 parts of lanolin.
8. Medicinal moxibustion for acute diarrhea according to claim 2, characterized in that the pharmaceutical composition I is prepared by the following method:
1) placing fructus evodiae, cortex Cinnamomi and flos Caryophylli into superfine jet mill, and pulverizing; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, and adding deionized water for extraction; filtering the traditional Chinese medicine liquid in the traditional Chinese medicine ultrasonic extraction machine to obtain nanometer traditional Chinese medicine ultrasonic extraction liquid;
2) placing the ultrasonic extraction liquid of the nano traditional Chinese medicine into a vacuum high-speed dispersion tank, sequentially adding isopropanol, ethanol, hydroxypropyl methylcellulose, lecithin, cholesterol and hyaluronic acid, and uniformly dispersing to obtain a nano traditional Chinese medicine ethosome;
3) placing nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding composite essential oil, sodium alginate, glycerol and deionized water, and uniformly dispersing to obtain the pharmaceutical composition I.
9. Medicinal moxibustion for acute diarrhea according to claim 3, characterized in that the preparation method of the pharmaceutical composition II is:
1) pulverizing semen Myristicae, fructus Piperis and folium Artemisiae Argyi into fine powder to obtain medicinal mixture;
2) oil phase: mixing the medicine mixture, radix bupleuri, oleic acid, isopropyl myristate and polyoxyethylene castor oil in an ice water bath, and uniformly stirring for 20-50 min to form an oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in an ice-water bath for 10-50 min to form a water phase;
4) microemulsion polymerization: and mixing the oil phase and the water phase, heating to 70-90 ℃ under an oxygen-free condition, carrying out ultrasonic dispersion, mechanically stirring at a speed of 400-800 r/min, carrying out microemulsion polymerization for 3-7 h, and cooling to room temperature to obtain a medicament composition II.
10. The method for preparing moxibustion for acute diarrhea according to claim 7, comprising the steps of:
1) preparation of the medicament patch: respectively preparing a medicament composition I and a medicament composition II, then uniformly mixing, and putting into a medicament bag to prepare a medicament patch;
2) preparing a heating bag:
A. weighing the macromolecular water-absorbing resin, the salt and the water according to the proportion, and uniformly mixing to obtain a water gel;
B. weighing propylene glycol, vaseline, monoglyceride, polyvinylpyrrolidone and lanolin according to a ratio, and uniformly mixing to obtain a coupling agent;
C. weighing iron powder, water gel, auxiliary dispersant, catalyst and coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3) and (3) mutually bonding the medicament patch prepared in the step 1) and the heating bag prepared in the step 2) to prepare the medicinal moxibustion for acute diarrhea.
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