CN111388555A - Patch for treating infantile diarrhea - Google Patents
Patch for treating infantile diarrhea Download PDFInfo
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- CN111388555A CN111388555A CN202010189732.5A CN202010189732A CN111388555A CN 111388555 A CN111388555 A CN 111388555A CN 202010189732 A CN202010189732 A CN 202010189732A CN 111388555 A CN111388555 A CN 111388555A
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- parts
- patch
- infantile diarrhea
- treating infantile
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- 208000019637 Infantile Diarrhea Diseases 0.000 title claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 235000002566 Capsicum Nutrition 0.000 claims abstract description 14
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims abstract description 14
- 239000006002 Pepper Substances 0.000 claims abstract description 14
- 235000016761 Piper aduncum Nutrition 0.000 claims abstract description 14
- 235000017804 Piper guineense Nutrition 0.000 claims abstract description 14
- 235000008184 Piper nigrum Nutrition 0.000 claims abstract description 14
- 235000017803 cinnamon Nutrition 0.000 claims abstract description 14
- 244000223014 Syzygium aromaticum Species 0.000 claims abstract description 13
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims abstract description 13
- 235000003805 Musa ABB Group Nutrition 0.000 claims abstract description 10
- 240000008790 Musa x paradisiaca Species 0.000 claims abstract description 10
- 235000015266 Plantago major Nutrition 0.000 claims abstract description 10
- 241001078983 Tetradium ruticarpum Species 0.000 claims abstract description 7
- 241000722363 Piper Species 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000011159 matrix material Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 4
- 229910021641 deionized water Inorganic materials 0.000 claims description 4
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- 239000004745 nonwoven fabric Substances 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 abstract description 8
- 238000010792 warming Methods 0.000 abstract description 5
- 210000000952 spleen Anatomy 0.000 abstract description 4
- 230000003213 activating effect Effects 0.000 abstract description 3
- 244000203593 Piper nigrum Species 0.000 abstract 2
- 206010047700 Vomiting Diseases 0.000 description 6
- 208000002193 Pain Diseases 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 230000008673 vomiting Effects 0.000 description 4
- 208000004998 Abdominal Pain Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 206010019909 Hernia Diseases 0.000 description 2
- 206010067171 Regurgitation Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000012639 Balance disease Diseases 0.000 description 1
- 241000589875 Campylobacter jejuni Species 0.000 description 1
- 244000025596 Cassia laevigata Species 0.000 description 1
- 235000006693 Cassia laevigata Nutrition 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 241000709661 Enterovirus Species 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 206010017367 Frequent bowel movements Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000031361 Hiccup Diseases 0.000 description 1
- 241000617996 Human rotavirus Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- 241000607734 Yersinia <bacteria> Species 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 229960004821 amikacin Drugs 0.000 description 1
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 201000009361 ascariasis Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 208000035474 group of disease Diseases 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229960001732 pipemidic acid Drugs 0.000 description 1
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 description 1
- 229940124513 senna glycoside Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 231100000033 toxigenic Toxicity 0.000 description 1
- 230000001551 toxigenic effect Effects 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a patch for treating infantile diarrhea, which comprises effective components and an external patch, wherein the effective components comprise the following raw materials in parts by weight: 6-8 parts of pepper, 8-10 parts of plantain seed, 5-8 parts of cinnamon, 4-8 parts of fructus evodiae and 6-11 parts of clove. The invention consists of pepper, plantain seed, cinnamon, evodia rutaecarpa and clove, and has the functions of resolving dampness, activating spleen, warming middle-jiao and checking diarrhea.
Description
Technical Field
The invention relates to the technical field of infantile diarrhea, in particular to a patch for treating infantile diarrhea.
Background
Infantile diarrhea is a group of diseases mainly caused by multiple pathogens and multiple factors. It is mainly characterized by increased stool frequency and changed properties, and can be accompanied by symptoms such as fever, emesis, abdominal pain, etc., and different degrees of water, electrolyte and acid-base balance disorder. Pathogens can be caused by viruses (mainly human rotaviruses and other enteroviruses), bacteria (pathogenic escherichia coli, toxigenic escherichia coli, hemorrhagic escherichia coli, invasive escherichia coli, salmonella typhimurium, campylobacter jejuni, yersinia, staphylococcus aureus, etc.), parasites, fungi, and the like. Parenteral infections, disturbances of the intestinal flora due to abuse of antibiotics, allergies, improper feeding and climatic factors can also cause diseases. Is a common disease of infants under 2 years old.
At present, western medicines for treating infantile diarrhea are orally taken with antibiotics such as pipemidic acid, gentamicin, ampicillin, erythromycin or amikacin. The antibiotic has strong influence on the balance of intestinal flora, and the umbilical region application therapy in the traditional Chinese medicine external treatment therapy is also a more common method for treating the infantile diarrhea.
Disclosure of Invention
Based on the technical problems in the background art, the invention provides a patch for treating infantile diarrhea.
The invention provides a patch for treating infantile diarrhea, which comprises effective components and an external patch, wherein the effective components comprise the following raw materials in parts by weight: 6-8 parts of pepper, 8-10 parts of plantain seed, 5-8 parts of cinnamon, 4-8 parts of fructus evodiae and 6-11 parts of clove.
Preferably, the raw materials of the effective components have the following values in parts by weight: 7 parts of pepper, 9 parts of semen plantaginis, 7 parts of cinnamon, 6 parts of fructus evodiae and 9 parts of clove.
Preferably, the external patch includes a non-woven fabric layer and a blank substrate.
Preferably, the blank matrix comprises the following components in parts by weight: 5-8 parts of deionized water, 0.01-0.03 part of disodium ethylene diamine tetraacetate and 2-4 parts of alcohol.
Preferably, the blank matrix comprises the following components in parts by weight: 6 parts of deionized water, 0.002 part of disodium ethylene diamine tetraacetate and 3 parts of alcohol.
Preferably, the concentration of the alcohol is 95%.
The preparation method of the patch for treating infantile diarrhea comprises the following steps of:
s1: the following materials are selected as raw materials for preparing pepper and plantain seed, and cinnamon, evodia rutaecarpa and clove are soaked and cleaned;
s2: drying the cleaned raw materials in the step S1, and grinding into powder;
s3; adding 15-20 parts of water into the medicinal powder obtained in the step S2, heating and boiling, and filtering to obtain a filtrate;
s4: concentrating the filtrate in S3 to obtain concentrated paste;
s5: and (4) putting the concentrated paste obtained in the step (S3) into a disinfection container for disinfection, and then putting the container to a shade place to normal temperature to obtain the active ingredients.
Preferably, the soaking time of the raw material in the S1 is 1-2 hours.
Preferably, in the step S3, a screen is used for filtering, and the mesh number of the screen is 200-300 meshes.
Preferably, the sterilization process in S5 is to heat the concentrated paste to 150 ℃ and 200 ℃ within 10-15 minutes, keep the temperature for 20-30 minutes, then cool the concentrated paste to 95 ℃, and finally keep the temperature in a container above 80 ℃.
The invention has the beneficial effects that: the patch for treating infantile diarrhea provided by the invention is hot in pepper, pungent in taste, capable of warming middle-jiao to relieve pain and killing parasites, and mainly used for treating abdominal psychroalgia, vomiting and diarrhea, ascariasis and the like; flos Caryophylli is pungent in flavor and warm in nature, enters lung, spleen, stomach and kidney meridians, and has effects of warming middle-jiao, warming kidney and lowering adverse qi, and can be used for treating diarrhea, singultus, emesis, regurgitation, psychroalgia of heart and abdomen, hernia, etc.; cinnamon is pungent, sweet and hot in taste, enters kidney, spleen, heart and liver channels, has the effects of tonifying fire and supporting yang, guiding fire to source, dispelling cold and relieving pain, and activating blood and dredging channels, and is used for treating cold pain in heart and abdomen, vomiting and diarrhea due to deficiency cold, impotence, cold womb, cold pain in waist and knee, asthma due to kidney deficiency, yang deficiency vertigo, conjunctival congestion and pharyngalgia, cold hernia, galloping, amenorrhea, dysmenorrheal and other symptoms; evodia rutaecarpa is hot, pungent and bitter in taste, has the functions of dispelling cold and relieving pain, calming adverse-rising energy and stopping vomiting, and supporting yang and stopping diarrhea, and is used for treating diseases such as deficiency-cold diarrhea, headache, colic, beriberi, dysmenorrhea, abdominal distention and pain, vomiting and acid regurgitation, aphtha and the like. The formula consists of pepper, plantain seed, cinnamon, evodia rutaecarpa and clove, and has the effects of resolving dampness, activating spleen, warming middle-jiao and checking diarrhea. Compared with the existing Dinggui navel paste, the invention obviously reduces the times of shit wetting and body twisting of a mouse senna leaf diarrhea model, and is obviously higher than the Dinggui navel paste and the montmorillonite powder of Missida.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
Example one
The embodiment provides a patch for treating infantile diarrhea, which comprises the following raw materials in parts by weight: 8 parts of pepper, 10 parts of plantain seed, 8 parts of cinnamon, 8 parts of fructus evodiae and 11 parts of clove;
the preparation method comprises the following steps:
s1: selecting the following materials as raw materials for preparing pepper and plantain seed, and soaking cinnamon, evodia rutaecarpa and clove for 1 hour and then cleaning;
s2: drying the cleaned raw materials in the step S1, and grinding into powder;
s3; adding 15 parts of water into the medicinal powder obtained in the step S2, heating and boiling, and filtering by using a screen with the mesh number of 200 to obtain a filtrate;
s4: concentrating the filtrate in S3 to obtain concentrated paste;
s5: and (3) putting the concentrated paste obtained in the step (S3) into a disinfection container, heating to 150 ℃ within 10 minutes, keeping for 20 minutes, then cooling to 95 ℃, finally keeping the temperature in the container above 80 ℃, and then putting the container in a shade place to normal temperature to obtain the active ingredients.
Example two
The embodiment provides a patch for treating infantile diarrhea, which comprises the following raw materials in parts by weight: 7 parts of pepper, 9 parts of semen plantaginis, 7 parts of cinnamon, 6 parts of fructus evodiae and 9 parts of clove;
the preparation method comprises the following steps:
s1: selecting the following materials as raw materials for preparing pepper and plantain seed, and soaking cinnamon, evodia rutaecarpa and clove for 2 hours and then cleaning;
s2: drying the cleaned raw materials in the step S1, and grinding into powder;
s3; adding 20 parts of water into the medicinal powder obtained in the step S2, heating and boiling, and filtering by using a screen with the mesh number of 300 to obtain a filtrate;
s4: concentrating the filtrate in S3 to obtain concentrated paste;
s5: and (3) putting the concentrated paste obtained in the step (S3) into a disinfection container, heating to 200 ℃ within 15 minutes, keeping for 30 minutes, then cooling to 95 ℃, finally keeping the temperature in the container above 80 ℃, and then putting the container into a shade place to normal temperature to obtain the active ingredients.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (10)
1. The patch for treating infantile diarrhea is characterized by comprising effective components and an external patch, wherein the effective components comprise the following raw materials in parts by weight: 6-8 parts of pepper, 8-10 parts of plantain seed, 5-8 parts of cinnamon, 4-8 parts of fructus evodiae and 6-11 parts of clove.
2. The patch for treating infantile diarrhea according to claim 1, wherein the raw materials of the effective components are selected from the following materials in parts by weight: 7 parts of pepper, 9 parts of semen plantaginis, 7 parts of cinnamon, 6 parts of fructus evodiae and 9 parts of clove.
3. The patch for treating infantile diarrhea according to claim 1, wherein said patch for external use comprises a non-woven fabric layer and a blank matrix.
4. The patch for treating infantile diarrhea according to claim 3, wherein the blank matrix comprises the following components in parts by weight: 5-8 parts of deionized water, 0.01-0.03 part of disodium ethylene diamine tetraacetate and 2-4 parts of alcohol.
5. The patch for treating infantile diarrhea according to claim 4, wherein the blank matrix comprises the following components in parts by weight: 6 parts of deionized water, 0.002 part of disodium ethylene diamine tetraacetate and 3 parts of alcohol.
6. The patch for treating infantile diarrhea according to claim 4, wherein the concentration of alcohol is 95%.
7. The preparation method of the patch for treating infantile diarrhea comprises the following steps of:
s1: the following materials are selected as raw materials for preparing pepper and plantain seed, and cinnamon, evodia rutaecarpa and clove are soaked and cleaned;
s2: drying the cleaned raw materials in the step S1, and grinding into powder;
s3; adding 15-20 parts of water into the medicinal powder obtained in the step S2, heating and boiling, and filtering to obtain a filtrate;
s4: concentrating the filtrate in S3 to obtain concentrated paste;
s5: and (4) putting the concentrated paste obtained in the step (S3) into a disinfection container for disinfection, and then putting the container to a shade place to normal temperature to obtain the active ingredients.
8. The preparation method of the patch for treating infantile diarrhea according to claim 7, wherein the soaking time of the raw material in S1 is 1-2 hours.
9. The method for preparing a patch for treating infantile diarrhea as claimed in claim 7, wherein the S3 is filtered by a screen mesh with a mesh size of 200-300.
10. The method for preparing a patch for the treatment of infantile diarrhea as claimed in claim 7, wherein said sterilization process in S5 comprises heating the concentrated paste to 150 ℃ and 200 ℃ within 10-15 minutes, maintaining for 20-30 minutes, then cooling to 95 ℃, and finally keeping the temperature in a container above 80 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010189732.5A CN111388555A (en) | 2020-03-18 | 2020-03-18 | Patch for treating infantile diarrhea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010189732.5A CN111388555A (en) | 2020-03-18 | 2020-03-18 | Patch for treating infantile diarrhea |
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| CN111388555A true CN111388555A (en) | 2020-07-10 |
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| CN202010189732.5A Withdrawn CN111388555A (en) | 2020-03-18 | 2020-03-18 | Patch for treating infantile diarrhea |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111939205A (en) * | 2020-08-13 | 2020-11-17 | 国人健康管理(杭州)有限公司 | Medicinal moxibustion for acute diarrhea and preparation method thereof |
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| CN1876049A (en) * | 2006-04-24 | 2006-12-13 | 药都制药集团股份有限公司 | An externally applied powder for treating infant diarrhea |
| CN108619294A (en) * | 2017-03-23 | 2018-10-09 | 丁海燕 | A kind of Chinese herbs paste for treating baby diarrhea |
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2020
- 2020-03-18 CN CN202010189732.5A patent/CN111388555A/en not_active Withdrawn
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876049A (en) * | 2006-04-24 | 2006-12-13 | 药都制药集团股份有限公司 | An externally applied powder for treating infant diarrhea |
| CN108619294A (en) * | 2017-03-23 | 2018-10-09 | 丁海燕 | A kind of Chinese herbs paste for treating baby diarrhea |
Non-Patent Citations (1)
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| 王全梅，赵玉华: "内服外敷治疗小儿脾虚泄泻150例", 《河北中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111939205A (en) * | 2020-08-13 | 2020-11-17 | 国人健康管理(杭州)有限公司 | Medicinal moxibustion for acute diarrhea and preparation method thereof |
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