CN102600419B - Chinese medicinal composition for treating chronic appendagitis, and preparation method thereof - Google Patents
Chinese medicinal composition for treating chronic appendagitis, and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese medicinal composition for treating chronic appendagitis, which comprises Radix Stemonae, Polyporus, Rhizoma Ligustici Chuanxiong, Radix Semiaquilegiae, Semen Abutili, Lignum Dalbergiae Odoriferae, Cortex Ilicis Rotundae, Herba Clinopodii Polycephali, Folium Pyrrosiae, Rhizoma Alpiniae Officinarum, Fructus Malvae, Fructus Zanthoxyli, Flos Rosae Rugosae, Caulis Aristolochiae, Radix Rubiae, Semen Impatientis, Exocarpium Citri Rubrum, Ginseng Radix, Rhizoma Dioscoreae, Radix Platycodi and Caulis Bambusae In Taenia. The composition directly permeates into inflammatory mass to facilitate local drug absorption; and has the advantages of short treatment course, rapid on-set, and short administration time.
Description
Technical field
The present invention relates to the Chinese medicine field of engineering technology, relate in particular to a kind of Chinese medicine that is used for the treatment of chronic adnexitis.
Background technology
Chronic adnexitis is that gynecological's common disease is clinical common frdquently encountered disease, and the trend of rising arranged in recent years, its main diseases is because miscarriage, childbirth, uteroventral operation, unclean sexual life history or the inflammation of closing on organ spread, normal for acute pelvic inflammatory disease fail thoroughly to treat or patient's body constitution relatively poor, due to the course of disease delay, but also can there be the acute inflammation medical history, mainly showing as abdomen bob distending pain and lumbosacral region aches, the state of an illness is obstinate, be difficult for curing, easily outbreak repeatedly, and cause infertile more or cause ectopic pregnancy, great physical and mental health brought to the patient.
The pathological characteristic of chronic accessory inflammation is, the adnexa tissue is subjected to inflammatory stimulus repeatedly, tissue edema, inflammatory exudation, fibrosis, and form adhesion in various degree, local organization fibroplasia, minority form palp inflammatory mass, the local circulation obstacle, make medicine be difficult to infiltrate in the tissue, be difficult to reach the required concentration of Drug therapy.
Modern medicine proof chronic adnexitis is the mixed infection of multiple pathogen (aerobe, anaerobe, mycoplasma, chlamydia, virus etc.).Levofloxacin has stronger antibacterial action to various bacteria, and also better to mycoplasma, chlamydia curative effect, metronidazole is obvious to the anaerobe effect.
Chronic pelvic inflammatory disease is the doctor trained in Western medicine name of disease, and is similar to diseases such as the traditional Chinese medical science " married woman's stomachache ", " leukorrheal diseases ", its clinical manifestation sporadically appear again in the traditional Chinese medical science " Epileptic note of the ancient Chinese abdominal mass ", " menopathy ", among disease such as " dysmenorrhea "." General Treatise on the Cause and Symptoms of Diseases eight abdominal masss time " cloud: " if do not close negative and positive to the greatest extent through water, even married woman's blood vessels contraction is anxious, the heavy anxious distention and fullness of lower abdomen ... tie firm stagnant blood and do not remove, menses is gathered because giving birth to frequently." " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases " then point out: " the few abdomen of breast abdomen must have the traction tenderness person that has a pain for warm blood chamber ... for pathogenic heat is absorbed in, the knot and not all right of fighting.”
Theory of Chinese medical science thinks that the woman all is usefulness with blood through, pregnant, product, breast, CHONG meridian being the blood pool, appoint and be sea of yin channels (referring to Ren Channel), the essence and blood body fluid of owner's body, married woman menstrual period, puerperal, just opened the blood chamber, surplus blood is not to the greatest extent, easily hindered by six climate exopathogens, seven emotions, diet, overstrain and exhaustion due to sexual indulgence, with the passing of time easily formed cards such as qi depression to blood stasis, damp and hot stasis of blood knot or cold and stagnate, controlled wrong treatment because of mistake again, or the positive QI-insufficiency of body, with the passing of time the state of an illness delays, malicious evil obstruction of meridian, thrombosis, the stasis of blood is stagnant to be gathered and form, so " pathogen usually intruding into collateral in protracted disease ", " prolonged illness must have the stasis of blood "." reading random notes " " the Ye Tianshi meaning: prolonged illness must be controlled network.Its so-called sick QI and blood is for a long time carried out discord, must have the stasis of blood to coagulate among the blood network.So disease causes to twine to prolong and do not go, must dredge its network and pathogenic QI in the body can be use up also." the pathogenesis key of visible chronic adnexitis is " stasis of blood ", " knot ".
" treatise on blood trouble " said: " card that all are not controlled, always by be not good at blood stasis removing so, all persons that controls blood, must be earlier with blood stasis removing for wanting.", it is considered herein that primary Therapeutic Principle should be blood stasis-eliminating and stagnation-dissipating at the pathogenesis key of chronic adnexitis " stasis of blood ", " knot ", removing obstruction in the collateral to relieve pain not bitterly, finally plays the effect of removing obstruction for relieving pain in the hope of reaching logical.
Summary of the invention
Technical problem to be solved by this invention is, utilize the traditional theory of Chinese medical science of China, a kind of novel Chinese medicine for oral administration compositions is provided, according to heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating, the Therapeutic Principle of removing obstruction in the collateral to relieve pain, by mode for oral administration medicine is directly permeated in inflammatory mass, be conducive to the absorption of topical remedy, thereby well treat chronic adnexitis, have short treating period, instant effect, the short advantage of administration time.
Ask in order to solve above-mentioned technology, the invention provides a kind of Chinese medicine for the treatment of chronic adnexitis, it comprises: the Radix Stemonae, Polyporus, Rhizoma Chuanxiong, Radix Semiaquilegiae, Semen Abutili, Lignum Dalbergiae Odoriferae, Cortex Ilicis Rotundae, Herba Clinopodii, Folium Pyrrosiae, Rhizoma Alpiniae Officinarum, Fructus Malvae, Pericarpium Zanthoxyli, Flos Rosae Rugosae, Herba Aristolochiae, Radix Rubiae, Semen Impatientis, dried tangerine peel, Radix Ginseng, Rhizoma Dioscoreae, Radix Platycodonis and Caulis Bambusae In Taenia.
Wherein, the ratio of weight and number of each component in the described Chinese medicine is the Radix Stemonae 10～20 weight portions, Polyporus 25～35 weight portions, Rhizoma Chuanxiong 40～50 weight portions, Radix Semiaquilegiae 60～70 weight portions, Semen Abutili 60～70 weight portions, Lignum Dalbergiae Odoriferae 15～25 weight portions, Cortex Ilicis Rotundae 60～70 weight portions, Herba Clinopodii 40～50 weight portions, Folium Pyrrosiae 25～35 weight portions, Rhizoma Alpiniae Officinarum 10～20 weight portions, Fructus Malvae 40～50 weight portions, Pericarpium Zanthoxyli 10～20 weight portions, Flos Rosae Rugosae 20～30 weight portions, Herba Aristolochiae 25～35 weight portions, Radix Rubiae 25～35 weight portions, Semen Impatientis 20～30 weight portions, tangerine 10～20 weight portions, Radix Ginseng 15～25 weight portions, Rhizoma Dioscoreae 15～25 weight portions, Radix Platycodonis 20～30 weight portions and Caulis Bambusae In Taenia 75～85 weight portions.
Wherein, the ratio of weight and number of each component in the described Chinese medicine Radix Stemonae 15～20 weight portions more preferably, Polyporus 30～35 weight portions, Rhizoma Chuanxiong 45～50 weight portions, Radix Semiaquilegiae 65～70 weight portions, Semen Abutili 65～70 weight portions, Lignum Dalbergiae Odoriferae 20～25 weight portions, Cortex Ilicis Rotundae 65～70 weight portions, Herba Clinopodii 45～50 weight portions, Folium Pyrrosiae 30～35 weight portions, Rhizoma Alpiniae Officinarum 15～20 weight portions, Fructus Malvae 45～50 weight portions, Pericarpium Zanthoxyli 15～20 weight portions, Flos Rosae Rugosae 25～30 weight portions, Herba Aristolochiae 30～35 weight portions, Radix Rubiae 30～35 weight portions, Semen Impatientis 25～30 weight portions, tangerine 15～20 weight portions, Radix Ginseng 20～25 weight portions, Rhizoma Dioscoreae 20～25 weight portions, Radix Platycodonis 25～30 weight portions and Caulis Bambusae In Taenia 80～85 weight portions.
Wherein, the ratio of weight and number of each component in the described Chinese medicine Radix Stemonae 18 weight portions more preferably, Polyporus 32 weight portions, Rhizoma Chuanxiong 48 weight portions, Radix Semiaquilegiae 68 weight portions, Semen Abutili 68 weight portions, Lignum Dalbergiae Odoriferae 23 weight portions, Cortex Ilicis Rotundae 67 weight portions, Herba Clinopodii 48 weight portions, Folium Pyrrosiae 33 weight portions, Rhizoma Alpiniae Officinarum 18 weight portions, Fructus Malvae 44 weight portions, Pericarpium Zanthoxyli 18 weight portions, Flos Rosae Rugosae 27 weight portions, Herba Aristolochiae 32 weight portions, Radix Rubiae 33 weight portions, Semen Impatientis 28 weight portions, tangerine 17 weight portions, Radix Ginseng 22 weight portions, Rhizoma Dioscoreae 23 weight portions, Radix Platycodonis 28 weight portions and Caulis Bambusae In Taenia 82 weight portions.
The present invention also provides above-mentioned preparation method of Chinese medicine, and it may further comprise the steps,
The first step, described component is mixed in proportion, put into super micron mill and be ground into the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, the powder rate that gets of described mixed powder is at least 95%;
Second step, in the mixed powder that the first step obtains, add determining alcohol with respect to 3～5 times of the quality of described mixed powder and be 85%～95% ethanol, stirring and dissolving obtains alcoholic solution, alcoholic solution was left standstill 24～36 hours under 5 ℃～10 ℃ condition, adopt percolation with the speed of per minute 1～2ml percolation slowly, collect percolate, concentrate and drying, and put into super micron mill at this and pulverized 40～60 minutes, obtain the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, the powder rate that gets of described mixed powder is at least 95%;
In the 3rd step, the mixed powder that obtains is prepared into needed various dosage form according to the preparation method of regular dosage form as required.
Wherein, when described Chinese medicine is prepared into the dosage form of injectable powder, described the 3rd step is specially, get mixed powder 10g～20g that second step obtained, add propylene glycol 30g～50g, add 200ml water for injection, stirring makes its dissolving, further add the injection water to 1000ml, add 1g～1.5g needle-use activated carbon again, fully stirred 30～50 minutes; Decarbonization filtering; With 0.22～0.24 μ m filtering with microporous membrane; Lyophilization gets sterilized powder, the packing embedding.
Wherein, when described Chinese medicine was prepared into glucose injection, described the 3rd step was specially, and gets mixed powder 4～6g that second step obtained, and adds Polyethylene Glycol 10g～20g, adds glucose 500g～700g, adds 2000ml water for injection, stirs and makes its dissolving; Continue to add the injection water to 5000ml; With 0.22 μ m filtering with microporous membrane; The packing embedding, every bottle of 100ml, sterilization gets final product.
Wherein, when described Chinese medicine was prepared into sodium chloride injection, described the 3rd step was specially, and gets mixed powder 1～3g that second step obtained, and adds sodium chloride 90～110g, adds 1000ml water for injection, stirs and makes its dissolving; Add the injection water to 10000ml; With 0.22 μ m filtering with microporous membrane; The packing embedding, every bottle of 250ml, sterilization gets final product.
Wherein, when described Chinese medicine was prepared into washing liquid, described the 3rd step was specially, and added the deionized water with respect to 2～3 times of mixed powder quality in the mixed powder of second step acquisition, decocted 2～4 hours, filtered, and obtained medicine juice.
When adopting washing liquid, get 150～250ml medicine juice, be cooled to temperature to splash into boiling hot being advisable of forearm.Every day 1 time, insert anus 15～20cm with enemator or medium size catheter before sleeping, medicinal liquid is slowly injected rectum.After extracting, raise buttocks, left lateral position.
Wherein, the dosage form of described Chinese medicine is injectable powder, glucose injection, sodium chloride injection or washing liquid.
Beneficial effect of the present invention:
Chinese medicine provided by the invention directly permeates in inflammatory mass, is conducive to the absorption of topical remedy, thereby well treats chronic adnexitis, has short treating period, instant effect, the short advantage of administration time.
The specific embodiment
The invention provides a kind of Chinese medicine for the treatment of chronic adnexitis, it comprises: the Radix Stemonae, Polyporus, Rhizoma Chuanxiong, Radix Semiaquilegiae, Semen Abutili, Lignum Dalbergiae Odoriferae, Cortex Ilicis Rotundae, Herba Clinopodii, Folium Pyrrosiae, Rhizoma Alpiniae Officinarum, Fructus Malvae, Pericarpium Zanthoxyli, Flos Rosae Rugosae, Herba Aristolochiae, Radix Rubiae, Semen Impatientis, dried tangerine peel, Radix Ginseng, Rhizoma Dioscoreae, Radix Platycodonis and Caulis Bambusae In Taenia.
The Radix Stemonae: sweet in the mouth, hardship, slightly warm in nature is returned lung meridian, has the effect of nourishing the lung to keep the adverse QI downward, cough-relieving parasite killing, is used for new chronic cough and coughs pulmonary tuberculosis cough, pertussis, head louse, body louse, enterobiasis, cards such as pudendum Pruritus.
Polyporus: sweet in the mouth, light, property is flat, goes into kidney, urinary bladder channel, has the effect of promoting diuresis to eliminate damp pathogen, is mainly used in the edema of retention of water-damp, dysuria, and the having loose bowels, vomit of stagnation of dampness due to deficiency of the spleen; Cards such as the leucorrhea of damp invasion of lower energizer, nebulousurine.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel, have blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, the effect of wind-expelling pain-stopping cures mainly headache, menoxenia, the amenorrhea dysmenorrhea, puerperal, the stasis of blood stagnated raw meat bitterly, the lump in the abdomen lump, pain in chest and hypochondrium, it is dizzy to have a headache, anemofrigid-damp arthralgia, traumatic injury, cards such as ulcer sores, " book on Chinese herbal medicine is just ": Rhizoma Chuanxiong, its property is kind looses, and walks Liver Channel again, and the blood medicine in the gas also.Anti-Rhizoma et radix veratri (Radix Rhizoma Veratri), fear Sal Nitri, Talcum, Rhizoma Coptidis person make it with its heavy trembling with fear and rise diffusing property also.Chinese herbaceous peony is returned all genus blood medicines, and loosing of rhizome of chuanxiong is moving more so in returning, so the energy dispersing wind and cold is controlled headache, removing blood stasis with potent drugs holds, and promoting blood circulation is separated stagnation of QI, and by pain, the evacuation of pus detumescence is stimulated the menstrual flow by blood.With the Herba Asari decoction, control incised wound and have a pain; With its gas lift, so the dizzy fortune of reason metrorrhagia of holding concurrently is sweet few with it, then have a surplus so loose, mend then deficiency, only the headache of wind and cold extremely should be used it.If three YANG-fire are stopped up in last and pain person must rise instead very, moderns fail to understand lifting, and but know that Rhizoma Chuanxiong controls headache, wrong also very.
Radix Semiaquilegiae: sweet in the mouth, little hardship, little suffering, cold in nature, mild toxicity is returned liver, spleen, urinary bladder channel, has heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the effect of relieving stranguria by diuresis.It is frightened to cure mainly children's's heat, epilepsy, carbuncle, furuncle, acute mastitis, scrofula, skin itching sore, conjunctival congestion and swelling pain, pharyngalgia, snake bite and insect sting, pyretic stranguria, cards such as sand Stranguria.
Semen Abutili: bitter in the mouth, property is flat, returns large intestine, small intestinal, urinary bladder channel, has clearing away heat-damp and promoting diuresis, and the effect of detoxifcation nebula removing is used for dysentery, the puckery pain of gonorrhea, cards such as carbuncle corneal nebula.
Lignum Dalbergiae Odoriferae: acrid in the mouth, warm in nature, return liver, spleen channel, have promoting flow of QI and blood, the effect of analgesic hemostatic.Be used for epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, cards such as traumatic hemorrhage.
Cortex Ilicis Rotundae: cold in nature, bitter in the mouth is gone into lung, liver, large intestine channel, has the effect of heat-clearing and toxic substances removing, dampness removing, pain relieving, cures mainly cards such as cold, fever, laryngopharynx swelling and pain, stomachache, administration's diarrhea due to damp pathogen rush down, jaundice, dysentery, traumatic injury, rheumatic arthralgia, eczema, furuncle.
Herba Clinopodii: mildly bitter flavor, puckery, cool in nature, return Liver Channel, have heat-clearing and toxic substances removing, the effect of removing heat from blood and promoting blood circulation cures mainly anemopyretic cold; Cough; Conjunctival congestion and swelling pain; Laryngopharynx swelling and pain; Diphtheria; Stomachache dysentery; Spit blood; Spitting of blood; Hematuria; Metrorrhagia; Traumatic hemorrhage; Hepatitis; Cholecystitis; Narrow rib; Stomachache; Arthralgia; Skin infection is swollen; Venom; Eczema; Hemorrhoid; Cards such as treating swelling and pain by traumatic injury.
Folium Pyrrosiae: sweet in the mouth, hardship, cold nature is returned lung, urinary bladder channel, has relieving stranguria by diuresis, and the effect that lung heat clearing expels the heat-evil cures mainly and drenches pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, cards such as carbuncle.
Rhizoma Alpiniae Officinarum: acrid in the mouth, hot in nature, return spleen, stomach warp, have warming stomach for dispelling cold, the effect of the pain relieving that helps digestion.Be used for coldness and pain in the epigastrium, gastrofrigid vomiting, cards such as belch acid regurgitation.
Fructus Malvae: sweet in the mouth, puckery, cool in nature, have clearing away heat and promoting diuresis, the effect of detumescence is used for urine retention, and edema is thirsty; Cards such as urinary tract infection.
Pericarpium Zanthoxyli: acrid in the mouth, warm in nature, return spleen, stomach, kidney channel, have warming middle-JIAO to relieve pain, the effect of killing parasites for relieving itching.Be used for coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis, cards such as eczema pruritus.
Flos Rosae Rugosae: sweet in the mouth, little hardship, warm in nature, return liver, spleen channel, have promoting QI circulation for relieving depression, the effect of regulating blood flow to alleviate pains is used for stomachache due to hyperactive liver-QI attacking the stomach, the lack of appetite vomiting and nausea, cards such as pouncing on the pain of injury is fallen in menoxenia.
Herba Aristolochiae: bitter in the mouth, warm in nature, return liver, spleen, kidney channel has the circulation of qi promoting removing dampness, and the effect of promoting blood circulation and stopping pain cures mainly stomachache, colicky, edema during pregnancy, puerperal, vim and vigour were suffered from abdominal pain, cards such as rheumatalgia.
Radix Rubiae: cold in nature, bitter in the mouth is returned liver; The heart; Kidney; Spleen; Stomach; Pericardium channel has the effect of cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling, cures mainly diseases such as heat in blood spitting of blood, postpartum stagnation stomachache, traumatic injury, rheumatic arthralgia.
Semen Impatientis: little hardship, suffering, warm in nature, return lung, Liver Channel, have the effect anticancer, that loose and become silted up and subside a swelling that relieves internal heat, cure mainly the removing blood stasis softening the hard mass, removing food stagnancy ， WEIJIA mass in the abdomen, amenorrhea, the dysphagic card that waits.
Tangerine: acrid in the mouth, hardship, warm in nature, return lung, spleen channel, have cold expelling dampness, the effect of promoting the circulation of QI expectorant is used for the cough due to wind and cold, the itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine, the vexed card that waits of vomiting and nausea painful abdominal mass.
Radix Ginseng: property is flat, sweet in the mouth, little hardship, tepor, return spleen, lung meridian, heart channel, have strongly invigorating primordial QI, multiple arteries and veins takes off invigorating the spleen to benefit the lung admittedly, promoting the production of body fluid to quench thirst, the calm the nerves effect of Fructus Alpiniae Oxyphyllae, cure mainly that impairment caused by overstrain is deficient, lack of appetite, asthenia, regurgitation are told food, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency be multiple, the disease of all qi-blood-body fluid deficiencies.
Rhizoma Dioscoreae: sweet in the mouth, property are put down, and go into lung, spleen, stomach warp, and the spleen reinforcing nourishing the stomach is arranged, and lung benefiting reinforces the kidney, and the effect of YIN nourishing and the production of body fluid promoting is mainly used in weakness of the spleen and stomach, the lack of appetite poor appetite of dysfunction of the spleen in transportation, symptoms such as the vexed diarrhoea of gastral cavity.
Radix Platycodonis: bitter in the mouth, suffering, slightly warm in nature is gone into lung meridian.Have expelling phlegm for arresting cough, and lung qi dispersing, evacuation of pus effect are arranged, cure mainly cards such as cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.
Caulis Bambusae In Taenia: cold nature, sweet in the mouth attaches to the lung and stomach meridians, and has removing heat-phlegm, and the effect that relieves restlessness and prevents vomiting is held cards such as expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm for phlegm-heat cough, gallbladder fire.
Wherein, the ratio of weight and number of each component in the described Chinese medicine is the Radix Stemonae 10～20 weight portions, Polyporus 25～35 weight portions, Rhizoma Chuanxiong 40～50 weight portions, Radix Semiaquilegiae 60～70 weight portions, Semen Abutili 60～70 weight portions, Lignum Dalbergiae Odoriferae 15～25 weight portions, Cortex Ilicis Rotundae 60～70 weight portions, Herba Clinopodii 40～50 weight portions, Folium Pyrrosiae 25～35 weight portions, Rhizoma Alpiniae Officinarum 10～20 weight portions, Fructus Malvae 40～50 weight portions, Pericarpium Zanthoxyli 10～20 weight portions, Flos Rosae Rugosae 20～30 weight portions, Herba Aristolochiae 25～35 weight portions, Radix Rubiae 25～35 weight portions, Semen Impatientis 20～30 weight portions, tangerine 10～2 () weight portion, Radix Ginseng 15～25 weight portions, Rhizoma Dioscoreae 15～25 weight portions, Radix Platycodonis 20～30 weight portions and Caulis Bambusae In Taenia 75～85 weight portions.
Wherein, the ratio of weight and number of each component in the described Chinese medicine Radix Stemonae 15～20 weight portions more preferably, Polyporus 30～35 weight portions, Rhizoma Chuanxiong 45～50 weight portions, Radix Semiaquilegiae 65～70 weight portions, Semen Abutili 65～70 weight portions, Lignum Dalbergiae Odoriferae 20～25 weight portions, Cortex Ilicis Rotundae 65～70 weight portions, Herba Clinopodii 45～50 weight portions, Folium Pyrrosiae 30～35 weight portions, Rhizoma Alpiniae Officinarum 15～20 weight portions, Fructus Malvae 45～50 weight portions, Pericarpium Zanthoxyli 15～20 weight portions, Flos Rosae Rugosae 25～30 weight portions, Herba Aristolochiae 30～35 weight portions, Radix Rubiae 30～35 weight portions, Semen Impatientis 25～30 weight portions, tangerine 15～20 weight portions, Radix Ginseng 20～25 weight portions, Rhizoma Dioscoreae 20～25 weight portions, Radix Platycodonis 25～30 weight portions and Caulis Bambusae In Taenia 80～85 weight portions.
Wherein, the ratio of weight and number of each component in the described Chinese medicine Radix Stemonae 18 weight portions more preferably, Polyporus 32 weight portions, Rhizoma Chuanxiong 48 weight portions, Radix Semiaquilegiae 68 weight portions, Semen Abutili 68 weight portions, Lignum Dalbergiae Odoriferae 23 weight portions, Cortex Ilicis Rotundae 67 weight portions, Herba Clinopodii 48 weight portions, Folium Pyrrosiae 33 weight portions, Rhizoma Alpiniae Officinarum 18 weight portions, Fructus Malvae 44 weight portions, Pericarpium Zanthoxyli 18 weight portions, Flos Rosae Rugosae 27 weight portions, Herba Aristolochiae 32 weight portions, Radix Rubiae 33 weight portions, Semen Impatientis 28 weight portions, tangerine 17 weight portions, Radix Ginseng 22 weight portions, Rhizoma Dioscoreae 23 weight portions, Radix Platycodonis 28 weight portions and Caulis Bambusae In Taenia 82 weight portions.
The present invention also provides above-mentioned preparation method of Chinese medicine, and it may further comprise the steps,
The first step, described component is mixed in proportion, put into super micron mill and be ground into the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, the powder rate that gets of described mixed powder is at least 95%;
Second step, in the mixed powder that the first step obtains, add determining alcohol with respect to 3～5 times of the quality of described mixed powder and be 85%～95% ethanol, stirring and dissolving obtains alcoholic solution, alcoholic solution was left standstill 24～36 hours under 5 ℃～10 ℃ condition, adopt percolation with the speed of per minute 1～2ml percolation slowly, collect percolate, concentrate and drying, and put into super micron mill at this and pulverized 40～60 minutes, obtain the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, the powder rate that gets of described mixed powder is at least 95%;
In the 3rd step, the mixed powder that obtains is prepared into needed various dosage form according to the preparation method of regular dosage form as required.
Application by micronizing, both can improve the utilization rate of medical material, be conducive to the stripping of effective active composition, improve drug bioavailability, thereby reach the minimizing dosage, save natural resources of Chinese medicinal materials, compare with traditional disintegrating process, micronizing can adopt the pulverizing at ultralow temperature measure of low temperature even-50 ℃, has improved the stability of protein-based thermal sensitivity effective ingredient in the animal drug, guarantees clinical efficacy.Micronizing improves the quality of the pharmaceutical preparations because the powder footpath is little, and particle size distribution is little, granularity is more even simultaneously, and stripping is rapid, and is rapid-action, and clinical efficacy is stable.
When described Chinese medicine is prepared into the dosage form of injectable powder, described the 3rd step is specially, get mixed powder 10g～20g that second step obtained, add propylene glycol 30g～50g, add 200ml water for injection, stir and make its dissolving, further add the injection water to 1000ml, add 1g～1.5g needle-use activated carbon again, fully stirred 30～50 minutes; Decarbonization filtering; With 0.22～0.24 μ m filtering with microporous membrane; Lyophilization gets sterilized powder, the packing embedding.
When adopting injectable powder, it is dissolved in the water for injection, carry out intravenous drip.
When described Chinese medicine was prepared into glucose injection, described the 3rd step was specially, and gets mixed powder 4～6g that second step obtained, and adds Polyethylene Glycol 10g～20g, adds glucose 500g～700g, adds 2000ml water for injection, stirs and makes its dissolving; Continue to add the injection water to 5000ml; With 0.22～0.24 μ m filtering with microporous membrane; The packing embedding, every bottle of 100ml, sterilization gets final product.
When adopting glucose injection, its administering mode is intravenous drip, every day 300ml.
When described Chinese medicine was prepared into sodium chloride injection, described the 3rd step was specially, and gets mixed powder 1～3g that second step obtained, and adds sodium chloride 90～110g, adds 1000ml water for injection, stirs and makes its dissolving; Add the injection water to 10000ml; With 0.22～0.24 μ m filtering with microporous membrane; The packing embedding, every bottle of 250ml, sterilization gets final product.
When adopting sodium chloride injection, its administering mode is intravenous drip, every day 500ml.
When described Chinese medicine was prepared into washing liquid, described the 3rd step was specially, and added the deionized water with respect to 2～3 times of mixed powder quality in the mixed powder of second step acquisition, decocted 2～4 hours, filtered, and obtained medicine juice.
When adopting washing liquid, get 150～250ml medicine juice, be cooled to 35～37 ℃ and be advisable.Every day 1 time, washing liquid is injected 1 property infusion bottle, syringe needle is pulled up, 1 property anal canal is inserted in the transfusion device lower end, after the emptying defecation, anal canal is slowly filled in the about 15cm of anal place medicine is splashed into rectum before sleeping every day, after extracting, raise buttocks, left lateral position.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
The injectable powder of embodiment 1 Chinese medicine preparation of the present invention
With Radix Stemonae 18g, Polyporus 32g, Rhizoma Chuanxiong 48g, Radix Semiaquilegiae 68g, Semen Abutili 68g, Lignum Dalbergiae Odoriferae 23g, Cortex Ilicis Rotundae 67g, Herba Clinopodii 48g, Folium Pyrrosiae 33g, Rhizoma Alpiniae Officinarum 18g, Fructus Malvae 44g, Pericarpium Zanthoxyli 18g, Flos Rosae Rugosae 27g, Herba Aristolochiae 32g, Radix Rubiae 33g, Semen Impatientis 28g, tangerine 17g, Radix Ginseng 22g, Rhizoma Dioscoreae 23g, Radix Platycodonis 28g and Caulis Bambusae In Taenia 82g mix, put into super micron mill and be ground into the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, described mixed powder the powder rate be 95%, the determining alcohol that adds 3100g in the mixed powder that obtains is 95% ethanol, stirring and dissolving obtains alcoholic solution, alcoholic solution was left standstill under 5 ℃ condition 36 hours, adopt percolation with the speed of per minute 2ml percolation slowly, collect percolate, concentrate and drying, and put into super micron mill at this and pulverized 60 minutes, obtain the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, described mixed powder the powder rate be 97%, get the mixed powder 15g of acquisition, add propylene glycol 30g, add 200ml water for injection, stirring makes its dissolving, further add the injection water to 1000ml, add the 1g needle-use activated carbon again, fully stirred 50 minutes; Decarbonization filtering; With 0.24 μ m filtering with microporous membrane; Lyophilization gets sterilized powder, the packing embedding.
The glucose injection of embodiment 2 Chinese medicine preparations of the present invention
With Radix Stemonae 18g, Polyporus 32g, Rhizoma Chuanxiong 48g, Radix Semiaquilegiae 68g, Semen Abutili 68g, Lignum Dalbergiae Odoriferae 23g, Cortex Ilicis Rotundae 67g, Herba Clinopodii 48g, Folium Pyrrosiae 33g, Rhizoma Alpiniae Officinarum 18g, Fructus Malvae 44g, Pericarpium Zanthoxyli 18g, Flos Rosae Rugosae 27g, Herba Aristolochiae 32g, Radix Rubiae 33g, Semen Impatientis 28g, tangerine 17g, Radix Ginseng 22g, Rhizoma Dioscoreae 23g, Radix Platycodonis 28g and Caulis Bambusae In Taenia 82g mix, put into super micron mill and be ground into the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, described mixed powder the powder rate be 95%, the determining alcohol that adds 3100g in the mixed powder that obtains is 95% ethanol, stirring and dissolving obtains alcoholic solution, alcoholic solution was left standstill under 5 ℃ condition 36 hours, adopt percolation with the speed of per minute 2ml percolation slowly, collect percolate, concentrate and drying, and put into super micron mill at this and pulverized 60 minutes, obtain the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, described mixed powder the powder rate be 97%, get the mixed powder 6g of acquisition, add Polyethylene Glycol 20g, add glucose 500g, add 2000ml water for injection, stir and make its dissolving; Continue to add the injection water to 5000ml; With 0.22 μ m filtering with microporous membrane; The packing embedding, every bottle of 100ml, sterilization gets final product.
The sodium chloride injection of embodiment 3 Chinese medicine preparations of the present invention
With Radix Stemonae 18g, Polyporus 32g, Rhizoma Chuanxiong 48g, Radix Semiaquilegiae 68g, Semen Abutili 68g, Lignum Dalbergiae Odoriferae 23g, Cortex Ilicis Rotundae 67g, Herba Clinopodii 48g, Folium Pyrrosiae 33g, Rhizoma Alpiniae Officinarum 18g, Fructus Malvae 44g, Pericarpium Zanthoxyli 18g, Flos Rosae Rugosae 27g, Herba Aristolochiae 32g, Radix Rubiae 33g, Semen Impatientis 28g, tangerine 17g, Radix Ginseng 22g, Rhizoma Dioscoreae 23g, Radix Platycodonis 28g and Caulis Bambusae In Taenia 82g mix, put into super micron mill and be ground into the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, described mixed powder the powder rate be 95%, the determining alcohol that adds 3100g in the mixed powder that obtains is 95% ethanol, stirring and dissolving obtains alcoholic solution, alcoholic solution was left standstill under 5 ℃ condition 36 hours, adopt percolation with the speed of per minute 2ml percolation slowly, collect percolate, concentrate and drying, and put into super micron mill at this and pulverized 60 minutes, obtain the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, described mixed powder the powder rate be 97%, get the mixed powder 3g of acquisition, add sodium chloride 110g, add 1000ml water for injection, stir and make its dissolving; Add the injection water to 10000ml; With 0.24 μ m filtering with microporous membrane; The packing embedding, every bottle of 250ml, sterilization gets final product.
The washing liquid of embodiment 4 Chinese medicine preparations of the present invention
With Radix Stemonae 18g, Polyporus 32g, Rhizoma Chuanxiong 48g, Radix Semiaquilegiae 68g, Semen Abutili 68g, Lignum Dalbergiae Odoriferae 23g, Cortex Ilicis Rotundae 67g, Herba Clinopodii 48g, Folium Pyrrosiae 33g, Rhizoma Alpiniae Officinarum 18g, Fructus Malvae 44g, Pericarpium Zanthoxyli 18g, Flos Rosae Rugosae 27g, Herba Aristolochiae 32g, Radix Rubiae 33g, Semen Impatientis 28g, tangerine 17g, Radix Ginseng 22g, Rhizoma Dioscoreae 23g, Radix Platycodonis 28g and Caulis Bambusae In Taenia 82g mix, put into super micron mill and be ground into the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, described mixed powder the powder rate be 95%, the determining alcohol that adds 3100g in the mixed powder that obtains is 95% ethanol, stirring and dissolving obtains alcoholic solution, alcoholic solution was left standstill under 5 ℃ condition 36 hours, adopt percolation with the speed of per minute 2ml percolation slowly, collect percolate, concentrate and drying, and put into super micron mill at this and pulverized 60 minutes, obtain the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, described mixed powder the powder rate be 97%, the deionized water that in the mixed powder that obtains, adds 1500g, decocted 3 hours, filter, obtain medicine juice.
Clinical experiment
1.1 clinical data
Selected 300 routine cases all are my out-patient of institute, by prescription on individual diagnosis order numbering, use table of random number and are divided into treatment group and matched group at random.200 examples are organized in treatment, 21～46 years old age, 32.7 ± 3.8 years old mean age; The course of disease 3 months～7 years, average 3.6 ± 2.5 years; Motherhood history person 132 examples are wherein arranged, acute pelvic inflammatory disease history person 113 examples, abdominal history person 29 examples.Matched group 100 examples, 22～47 years old age, average 32.5 ± 4.2 years old; The course of disease 3 months～9 years, average 4.0 ± 3.1 years; Motherhood history person 77 examples are arranged, acute pelvic inflammatory disease history person 47 examples, abdominal history person 9 examples.Two groups of state of an illness similar substantially (P＞0.05) have comparability.
1.2 diagnostic criteria
" clinical disease diagnosis is according to curing the improvement standard " according to the Sun Chuanxing chief editor formulated.(1) lower abdomen dull pain, back and sacrum portion ache, and after the fatigue of being everlasting, the sexual intercourse and aggravation before and after the menstruation, part has leucorrhoea grow in quantity, menorrhagia, dysmenorrhea and infertile etc.(2) the normal hypsokinesis in uterus, limitation of activity, adhesion is fixed, and a side or bilateral adnexa thicken, and tenderness is arranged, and also can form lump.(3) B ultrasonic prompting adnexitis.Clinically get rid of in conjunction with imaging diagnosis: endometriosis, old ectopic pregnancy, pelvic tuberculosis etc.
1.3 Therapeutic Method
Treatment group: the washing liquid 150ml that adopts the embodiment of the invention 4 preparations, the medicine temperature is advisable with 35～37 ℃, injects the property infusion bottle 1 time, and syringe needle is pulled up, 1 property anal canal is inserted in the transfusion device lower end, after the emptying defecation, anal canal is slowly filled in the about 15cm of anal place medicine is splashed into coloclysis before sleeping every day, preferably remain to time morning, 14 days was 1 course for the treatment of, after 3～5 days, can continue following 1 course for the treatment of at interval, stop using menstrual period.Matched group 019%NaCl
250ml adds cefazolin sodium 5.0g, 1 intravenous drip every day, tinidazole liquid 0.8g, every day 1 dead point, 14 days was 1 course for the treatment of, observe routine blood test during the treatment, if leukocyte is lower than normal value, stops tinidazole liquid and finish drug withdrawal 1 Zhou Houzai 1 per course for the treatment of and carry out the 2nd course of therapy.
1.4 criterion of therapeutical effect
(1) recovery from illness: clinical symptoms and sign disappear, and gynecological and ultrasound diagnosis are normal; (2) take a turn for the better: clinical symptoms and sign alleviate, and gynecological and ultrasound diagnosis all have improvement; (3) invalid: each side does not have improvement after 3 course of therapy.
1.5 the result sees Table 1 and table 2.
Table 1 liang group therapeutic outcome comparative example (%)
| Group | The example number | Recovery from illness | Take a turn for the better | Invalid | Total effective rate |
| The treatment group | 200 | 147(73.5) | 50(25.0) | 3(1.5) | 98.5 |
| Matched group | 100 | 32(32.0) | 47(47.0) | 21(21.0) | 79.0 |
As can be seen from Table 1, adopt Chinese medicine of the present invention to treat, its curative effect will be significantly better than matched group.
Table 2 course for the treatment of and curative effect concern example
| Group | Cure routine number | 1 course for the treatment of | 2 courses for the treatment of | 3 courses for the treatment of |
| The treatment group | 147 | 93 | 35 | 19 |
| Matched group | 32 | 5 | 13 | 14 |
As can be seen from Table 2, adopt Chinese medicine of the present invention to treat, will be significantly less than the treatment course for the treatment of of matched group its course for the treatment of.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (8)
1. Chinese medicine for the treatment of chronic adnexitis, it is characterized in that the ratio of weight and number of each component in the described Chinese medicine is the Radix Stemonae 10～20 weight portions, Polyporus 25～35 weight portions, Rhizoma Chuanxiong 40～50 weight portions, Radix Semiaquilegiae 60～70 weight portions, Semen Abutili 60～70 weight portions, Lignum Dalbergiae Odoriferae 15～25 weight portions, Cortex Ilicis Rotundae 60～70 weight portions, Herba Clinopodii 40～50 weight portions, Folium Pyrrosiae 25～35 weight portions, Rhizoma Alpiniae Officinarum 10～20 weight portions, Fructus Malvae 40～50 weight portions, Pericarpium Zanthoxyli 10～20 weight portions, Flos Rosae Rugosae 20～30 weight portions, Herba Aristolochiae 25～35 weight portions, Radix Rubiae 25～35 weight portions, Semen Impatientis 20～30 weight portions, tangerine 10～20 weight portions, Radix Ginseng 15～25 weight portions, Rhizoma Dioscoreae 15～25 weight portions, Radix Platycodonis 20～30 weight portions and Caulis Bambusae In Taenia 75～85 weight portions.
2. Chinese medicine as claimed in claim 1, it is characterized in that: the ratio of weight and number of each component in the described Chinese medicine is the Radix Stemonae 15～20 weight portions, Polyporus 30～35 weight portions, Rhizoma Chuanxiong 45～50 weight portions, Radix Semiaquilegiae 65～70 weight portions, Semen Abutili 65～70 weight portions, Lignum Dalbergiae Odoriferae 20～25 weight portions, Cortex Ilicis Rotundae 65～70 weight portions, Herba Clinopodii 45～50 weight portions, Folium Pyrrosiae 30～35 weight portions, Rhizoma Alpiniae Officinarum 15～20 weight portions, Fructus Malvae 45～50 weight portions, Pericarpium Zanthoxyli 15～20 weight portions, Flos Rosae Rugosae 25～30 weight portions, Herba Aristolochiae 30～35 weight portions, Radix Rubiae 30～35 weight portions, Semen Impatientis 25～30 weight portions, tangerine 15～20 weight portions, Radix Ginseng 20～25 weight portions, Rhizoma Dioscoreae 20～25 weight portions, Radix Platycodonis 25～30 weight portions and Caulis Bambusae In Taenia 80～85 weight portions.
3. Chinese medicine as claimed in claim 1, it is characterized in that: the ratio of weight and number of each component in the described Chinese medicine is the Radix Stemonae 18 weight portions, Polyporus 32 weight portions, Rhizoma Chuanxiong 48 weight portions, Radix Semiaquilegiae 68 weight portions, Semen Abutili 68 weight portions, Lignum Dalbergiae Odoriferae 23 weight portions, Cortex Ilicis Rotundae 67 weight portions, Herba Clinopodii 48 weight portions, Folium Pyrrosiae 33 weight portions, Rhizoma Alpiniae Officinarum 18 weight portions, Fructus Malvae 44 weight portions, Pericarpium Zanthoxyli 18 weight portions, Flos Rosae Rugosae 27 weight portions, Herba Aristolochiae 32 weight portions, Radix Rubiae 33 weight portions, Semen Impatientis 28 weight portions, tangerine 17 weight portions, Radix Ginseng 22 weight portions, Rhizoma Dioscoreae 23 weight portions, Radix Platycodonis 28 weight portions and Caulis Bambusae In Taenia 82 weight portions.
4. as any described preparation method of Chinese medicine of claim 1 to 3, it is characterized in that, comprise the steps:
The first step, described component is mixed in proportion, put into super micron mill and be ground into the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, the powder rate that gets of described mixed powder is at least 95%;
Second step, in the mixed powder that the first step obtains, add determining alcohol with respect to 3～5 times of the quality of described mixed powder and be 85%～95% ethanol, stirring and dissolving obtains alcoholic solution, alcoholic solution was left standstill 24～36 hours under 5 ℃～10 ℃ condition, adopt percolation with the speed of per minute 1～2ml percolation slowly, collect percolate, concentrate and drying, and put into super micron mill at this and pulverized 40～60 minutes, obtain the micron particles of 0.1～10 μ m volume average particle size and the mixed powder that particle diameter is formed less than the nano-scale particle of 0.1 μ m volume average particle size, the powder rate that gets of described mixed powder is at least 95%;
In the 3rd step, the mixed powder that obtains is prepared into needed various dosage form according to the preparation method of regular dosage form as required.
5. preparation method of Chinese medicine as claimed in claim 4 is characterized in that:
When described Chinese medicine is prepared into the dosage form of injectable powder, described the 3rd step is specially, get mixed powder 10g～20g that second step obtained, add propylene glycol 30g～50g, add 200ml water for injection, stir and make its dissolving, further add the injection water to 1000ml, add 1g～1.5g needle-use activated carbon again, fully stirred 30～50 minutes; Decarbonization filtering; With 0.22～0.24 μ m filtering with microporous membrane; Lyophilization gets sterilized powder, the packing embedding.
6. preparation method of Chinese medicine as claimed in claim 4 is characterized in that:
When described Chinese medicine was prepared into glucose injection, described the 3rd step was specially, and gets mixed powder 4～6g that second step obtained, and adds Polyethylene Glycol 10g～20g, adds glucose 500g～700g, adds 2000ml water for injection, stirs and makes its dissolving; Continue to add the injection water to 5000ml; With 0.22 μ m filtering with microporous membrane; The packing embedding, every bottle of 100ml, sterilization gets final product.
7. preparation method of Chinese medicine as claimed in claim 4 is characterized in that:
When described Chinese medicine was prepared into sodium chloride injection, described the 3rd step was specially, and gets mixed powder 1～3g that second step obtained, and adds sodium chloride 90～110g, adds 1000ml water for injection, stirs and makes its dissolving; Add the injection water to 10000ml; With 0.22～0.24 μ m filtering with microporous membrane; The packing embedding, every bottle of 250ml, sterilization gets final product.
8. preparation method of Chinese medicine as claimed in claim 4 is characterized in that:
When described Chinese medicine was prepared into washing liquid, described the 3rd step was specially, and added the deionized water with respect to 2～3 times of mixed powder quality in the mixed powder of second step acquisition, decocted 2～4 hours, filtered, and obtained medicine juice.
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| CN103845468B (en) * | 2014-03-14 | 2015-08-19 | 刘正玲 | A kind ofly treat the bad Chinese medicine composition of involution of uterus of puerperal |
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| CN105031480A (en) * | 2015-09-11 | 2015-11-11 | 任瑞峰 | Traditional Chinese medicine composition for treating cold-damp coagulation type annexitis |
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