CN109394959B - Traditional Chinese medicine composition with skin cuticle repairing effect, aqueous extract and fermentation product of traditional Chinese medicine composition and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition with skin cuticle repairing effect, aqueous extract and fermentation product of traditional Chinese medicine composition and application of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicine compositions for repairing skin cuticle, and particularly relates to a traditional Chinese medicine composition with the effect of repairing skin cuticle, an aqueous extract and a fermentation product thereof, and application thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: 150-250 parts of radix rehmanniae recen, 150-250 parts of radix pseudostellariae, 120-200 parts of cortex dictamni, 90-150 parts of lily, 90-150 parts of liquorice, 90-150 parts of cortex moutan, 50-100 parts of oroxylum indicum and 50-100 parts of gentian. The traditional Chinese medicine composition is selected from natural plants, the extract prepared by water extraction and the ferment prepared by yeast fermentation of the composition can directly act on the damaged part of the skin cuticle, have no toxic or side effect, are simple and safe to use, have mild effect, can improve the immunity of the skin, promote the repair of the damaged cuticle and realize the barrier protection function of the skin so as to achieve the effect of skin health.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine compositions for repairing skin cuticle, and particularly relates to a traditional Chinese medicine composition with the effect of repairing skin cuticle, an aqueous extract and a fermentation product thereof, and application thereof.
Background
The stratum corneum is the outermost part of the epidermis, and healthy stratum corneum can prevent water loss in the skin and can block invasion of foreign matters, and is a protective barrier with an anti-seepage function. In real life, various environmental factors and human factors damaging the stratum corneum of the skin generally exist, such as increased solar radiation and air pollution caused by ozone holes; it is considered to be useless "dead skin" with excessive exfoliation; or improper skin care measures, and frequent mask application causes excessive hydration of the stratum corneum, excessive cleaning to cause stratum corneum lipid loss and the like. When the integrity of the stratum corneum is damaged, external factors stimulate sensory nerve endings between the basal layer of the epidermis and the dermis, discomfort such as stabbing pain, burning, tightness, pruritus and the like can occur, and in the case of serious damage to the stratum corneum, any slight stimulation can cause skin injury and inflammatory reaction, which often occur in facial skin.
Because the stratum corneum is damaged to cause the barrier function of the skin to be damaged, and the common cosmetics are easy to cause irritation, the damaged skin has higher requirements on the cosmetics, and the cosmetics which are mild, have no irritating components and have the effect of repairing the stratum corneum are suitable for use.
At present, a few cosmetics with the effect of repairing skin cuticle are declared on the market, a repair product adopting the components of the traditional Chinese medicine formula is more flexible, and a method and a means for confirming the declaration of the effect of the repair product are lacked. The damaged stratum corneum is easy to cause sensitive skin, intolerance to irritability of various factors is caused, endless troubles are brought to beauty lovers, and the dependence is easy to generate in drug treatment such as hormone, immunosuppression and the like. Therefore, how to safely, effectively and simply obtain the effective components of natural plants aiming at repairing the horny layer of the skin and apply the effective components to cosmetics is a problem to be solved at present.
Disclosure of Invention
The traditional Chinese medicine composition adopted by the invention is selected from natural plants, an extract prepared by water extraction and a ferment prepared by fermenting the composition with yeast can directly act on the damaged part of the skin cuticle, has no toxic or side effect, is simple and safe to use and mild in effect, can improve the skin immunity, promotes the repair of the damaged cuticle, realizes the barrier protection function of the damaged cuticle and achieves the effect of skin health.
The technical scheme adopted by the invention is as follows:
a traditional Chinese medicine composition comprises the following components in parts by weight:
150-250 parts of radix rehmanniae recen, 150-250 parts of radix pseudostellariae, 120-200 parts of cortex dictamni, 90-150 parts of lily, 90-150 parts of liquorice, 90-150 parts of cortex moutan, 50-100 parts of oroxylum indicum and 50-100 parts of gentian.
An aqueous extract of a traditional Chinese medicine composition is prepared by adding 10 times of pure water by weight into the traditional Chinese medicine composition, extracting for 1 hour in a vacuum homogenizing emulsifying pot at 95-100 ℃, and filtering to obtain a filtrate.
A fermented product of Chinese medicinal composition is prepared by mixing the Chinese medicinal composition and zymocyte to obtain initial system, adding 10 times of pure water, fermenting to obtain fermentation liquid, sterilizing, and filtering to obtain filtrate.
A fermentation product of a traditional Chinese medicine composition is prepared by adding 90-250 parts by mass of high-activity dry yeast into yeast serving as zymocyte.
In the fermentation step, the temperature is 25-45 ℃; the stirring speed is 0-50 rpm; the time is 4-24 h.
An application of the aqueous extract of a traditional Chinese medicine composition is that the aqueous extract is mixed into cosmetics according to the proportion of 1 to 60 percent by weight.
The application of fermented product of Chinese medicine composition is that the fermented product is mixed into cosmetics in the weight ratio of 1-60%.
The range of cosmetics used was: liquids, lotions, creams, gels, powders or powder-forming products.
Dried rehmannia root, according to 125 pages of the national pharmacopoeia 2015 edition, which is written by the national pharmacopoeia committee of 6 months 1 st edition in 2015 of the pharmaceutical science publishing house, has the following effects: clear heat and cool blood, nourish yin and promote the production of body fluid. Can be used for treating heat entering nutrient-blood, and macula due to warm toxicity. According to the records on page 3133 of traditional Chinese medicine dictionary, 6 th edition 2 nd edition of Shanghai science and technology Press, Nanjing university of traditional Chinese medicine, 2014, the decoction of rehmannia root is used for gastric lavage to inhibit the formation of immune rose forming cells in the spleen of a mouse, and has the function of improving the immune function. The radix rehmanniae decoction can resist the decrease of plasma corticosterone concentration caused by dexamethasone and prevent adrenal cortex atrophy when the rabbit is subjected to gastric lavage.
Radix pseudostellariae has the following effects according to the 68 pages in the first part of the 2015 edition of the Chinese pharmacopoeia (national pharmacopoeia) which is edited by the national pharmacopoeia committee of the 1 st edition of 6 months in 2015 of the Chinese medical science and technology publishing company: to replenish qi, invigorate the spleen, promote the production of body fluid and moisten the lung. Can be used for treating spleen deficiency, asthenia, and deficiency of both qi and yin. According to the records on page 463 of traditional Chinese medicine dictionary, which is edited by Nanjing university of traditional Chinese medicine in 6 th edition, 2014, Shanghai science and technology publishing company, the radix pseudostellariae decoction prolongs the average life and the maximum life of fruit flies, and has the effect of delaying aging.
The dittany bark has the following effects according to 110 pages of the first part of the 2015 edition of the Chinese pharmacopoeia (Chinese pharmacopoeia) which is edited by the national pharmacopoeia committee of the 1 st edition of 6 months in 2015 of Chinese medical science and technology publishing company: clear heat and dry dampness, dispel wind and remove toxicity. Can be used for treating damp-heat sore, yellow water dripping, eczema, rubella, scabies, sore, scabies, etc. According to the records on page 882 of the Chinese medicine dictionary of Nanjing Chinese medicine university, 6 th edition, 2 nd edition, 2014, Shanghai scientific and technical Press, the 1: 4 water extract of cortex Dictamni has inhibitory effect on various pathogenic fungi such as Trichophyton violaceum, Trichophyton concentricum and Trichophyton schoenlandi. The dictamnine and the thujavanine contained in the compound have obvious antibacterial effects on bacillus subtilis and certain fungi. The cortex dictamni water extract has obvious inhibiting effect on contact dermatitis caused by hapten 2, 4, 6-trinitrochlorobenzene and plantar reaction caused by particulate antigen Sheep Red Blood Cell (SRBC) after being administrated after various antigens are attacked. The water extract of the dittany bark can also obviously inhibit inflammatory reaction of mouse crus auricle and mouse foot sole caused by egg white caused by xylene, and the generation of mouse anti-SRBC antibodies, including obvious inhibition on the cell number of mouse spleen plaque formation and the serum hemolysin water average.
Lily has the following effects according to the 132 pages of the national pharmacopoeia 2015 edition, which is compiled by the national pharmacopoeia committee of 6 months 1 st edition of 2015 of the pharmaceutical scientific publishing house 2015: nourish yin and moisten lung, clear heart and induce tranquilization. According to the record of 1018 page of traditional Chinese medicine dictionary, edited by Nanjing university of traditional Chinese medicine at 6.2 th edition of Shanghai science and technology Press 2014, the delayed hypersensitivity reaction caused by Dinitrochlorobenzene (DNCB) is remarkably inhibited by irrigating the mice with 10g/kg of lily aqueous extract for 2 times a day and continuously for 10 days. The water-soluble polysaccharide (BHP) in the lily can promote the immune function of cells of an organism and has an obvious conditioning effect on the immune function of a mouse. The lily polysaccharide of 0.2 g/kg and 0.4g/kg is used for gastric lavage of mice with low immunity caused by cyclophosphamide, which can obviously improve the phagocytic percentage and the phagocytic index of abdominal macrophages of the mice with low immunity, promote the formation of hemolysin and hemolytic plaque, and promote the lymphocyte transformation function.
Licorice root, according to the Chinese pharmacopoeia 2015, published by the national pharmacopoeia committee of 1 st edition of 6 months in 2015, the first 87 pages of which have the following effects: tonify spleen and qi, clear heat and remove toxicity, relieve spasm and pain, and harmonize the drugs. Can be used for treating carbuncle, swelling and sore, and relieving drug toxicity and strong property. According to the record of the Shanghai science and technology Press 2014, 6 th edition, 2 nd edition, edited by Nanjing university of traditional Chinese medicine, page 685 of Chinese medicine, the licorice leachate externally inhibits Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, streptococcus B and the like, and the licorice hot water extract has insecticidal effect on clonorchis sinensis and antimicrobial effect. The freeze-dried water extract of Glycyrrhiza glabra L.in the case of intragastric administration of rats inhibits the function of adrenal-pituitary axis and promotes the production of rennin, and the Glycyrrhiza glabra L.preparation has adrenocorticoid-like effect. According to the records of the traditional Chinese medicine cosmetic science 38 edited by Liuhua Steel, version 1 of 11/2005 of Chinese medicine Press, licorice has the functions of resisting allergic reaction and detoxifying, can eliminate inflammation and toxic stimulation of skin, neutralize, relieve or reduce toxic substances of cosmetics, and can also prevent the allergic reaction of some cosmetics to some people.
Moutan bark, according to the first 172 pages of "chinese pharmacopoeia" 2015 edition, published by the national pharmacopoeia committee of 6 months 1 edition 2015 of chinese medical science and technology publishing house, has the following effects: clear heat and cool blood, activate blood and resolve stasis. It can be used for treating heat entering nutrient-blood, macula due to warm toxicity, carbuncle, swelling, and sore. According to records on pages 1367-1368 of a traditional Chinese medicine dictionary, which is compiled by Nanjing traditional Chinese medicine university at 6.2 edition of Shanghai science and technology Press, 25, 50 and 100mg/kg of cortex moutan total glycosides can obviously inhibit acute paw swelling of rats induced by carrageenan and ear edema of mice induced by xylene, and have an obvious dose-dependent relationship, the cortex moutan total glycosides (20-100 mg/kg) given 1 hour before inflammation has an obvious inhibiting effect on primary inflammation of rats with adjuvant arthritis, and the cortex moutan total glycosides (25-100 mg/kg) starts to be perfused 12 days after inflammation, and can obviously inhibit secondary inflammatory reaction of rats with adjuvant arthritis for 11 days continuously. 0.5-1 g/kg of paeonol is perfused into the stomach or 50-200 mg/kg of paeonol is injected into the abdominal cavity, and the paeonol has obvious inhibiting effect on carrageenan, egg white, formaldehyde, histamine, 5-hydroxytryptamine and bradykinin rat foot edema, dimethylbenzene mouse pinnacle swelling and the increase of permeability of abdominal cavity capillary vessels caused by acetic acid and endotoxin. Applying 5% cortex moutan powder cream (white yellowish cream prepared from cortex moutan) on topical skin injury. 27 cases of local acute eczema, 10 cases of seborrheic dermatitis, 2 cases of contact dermatitis and 1 case of neurodermatitis in clinical treatment; the course of the disease is 3 days to 3 years, and most of the disease is less than 1 month. As a result: 27 cases of acute eczema are taken for 2-20 days, 8 cases are cured, 5 cases have obvious effect, 6 cases are improved, and 8 cases are invalid; the 10 cases of seborrheic dermatitis are taken for 5-14 days, 2 cases are cured, 6 cases are improved, and 2 cases are invalid; 2 cases of contact dermatitis are taken for 3-5 days, 1 case is healed, and 1 case is ineffective; 1 example of neurodermatitis was not effective in half a month. In 4 effective cases, the rash recurred several days after drug withdrawal, and in 2 other cases, the drug withdrawal is caused by flushing, itching and burning.
Oroxylum indicum, according to the records of page 436 of the traditional Chinese medicine dictionary compiled by Nanjing university of traditional Chinese medicine of 6.2 th edition in 2014 of Shanghai science and technology Press, oroxylum indicum water decoction has an inhibitory effect on lipid peroxidation in prevention and treatment experiments. The seeds and stem bark contain baicalein, and have antiinflammatory and antiallergic effects.
Gentiana, according to the "chinese pharmacopoeia" 2015 edition 96 page of the national pharmacopoeia committee of the 1 st edition of 6 months in 2015 of chinese medical science and technology publishing house, the following effects are described: clear heat and dry dampness, purge liver and gallbladder fire. Can be used for treating jaundice due to damp-heat pathogen, eczema, pruritus, and conjunctival congestion due to liver fire. According to the records on page 754 of Chinese medicinal dictionary, Gentianoside has inhibitory effect on rat plantar edema caused by carrageenan, which is recorded by 6.6.2 edition of Shanghai science and technology Press in Nanjing Chinese medicinal university, 2014. The intraperitoneal injection of the gentiin has obvious inhibition effect on egg white and formaldehyde foot edema of rats, and an anti-inflammatory mechanism is related to the stimulation of the anti-inflammatory mechanism on a nerve-pituitary-adrenal cortex system. The gentisic alkali has obvious protective effect on the histamine shock of guinea pigs and the egg white anaphylactic shock of rats, and can also obviously reduce the permeability of capillary vessels of the rats. The gentian water extract is administrated before sensitization and before and after attack, similar to cortical hormone, can obviously inhibit mouse delayed type hypersensitivity caused by picryl chloride, and has antiallergic effect.
The names of the used Cosmetic raw materials of the traditional Chinese medicine components in INCI (International Nomenclature for Cosmetic raw materials) are respectively as follows: rehmannia glutinosa (REHMANNIA GLUTINOSA) root extract, PSEUDOSTELLARIA HETEROPHYLLA (PSEUDOSTELLARIA HETEROPHYLLA) root extract, Dictamnus DASYCARPUS (Dictamnus DASYCARPUS) root bark extract, Lilium CANDIDUM (LILIUM CANDIDUM) bulb extract, Glycyrrhiza URALENSIS (Glycyrrhiza URALENSIS) root extract, peony (Paeonia SUFFRUTICOSA) root bark extract, OROXYLUM INDICUM (OROXYLUM INDICUM) extract, and GENTIANA SCABRA (GENTIANA SCABRA) root extract.
The technical scheme provided by the invention has the beneficial effects that:
in order to achieve the purpose of repairing the skin cuticle, the invention takes the traditional Chinese medicine theory of China as guidance, Chinese medicine raw materials are screened through a large number of long-term experiments, radix rehmanniae, radix pseudostellariae, cortex dictamni, lily, liquorice, moutan bark, oroxylum indicum and gentian are effectively combined together, an extract prepared by water extraction and a ferment prepared by fermenting the composition through yeast are obtained, the effects of all the raw materials can generate a synergistic effect, the invention has the effects of improving the skin immunity and promoting the repair of the damaged skin cuticle, and the invention has the obvious effects of repairing and protecting the skin cuticle when being applied to cosmetics.
The aqueous extract of the traditional Chinese medicine composition is prepared by adding 10 times of pure water by weight into the traditional Chinese medicine composition, extracting for 1 hour in a vacuum homogenizing emulsifying pot at 95-100 ℃, and filtering to obtain filtrate; the traditional Chinese medicine fermentation product is an initial system obtained by mixing the traditional Chinese medicine composition and zymocyte, 10 times of pure water by weight is added, and fermentation liquor obtained by fermentation is sterilized and filtered to obtain filtrate. Can directly act on the damaged part of the skin, has no toxic or side effect, and is simple and convenient to use. Can improve skin immunity, promote the repair of damaged stratum corneum, realize the barrier protection function of the skin, and achieve the effect of skin health. Has mild and non-irritant action, can be used for a long time, has simple process when being added into cosmetics, and is suitable for industrial production.
The aqueous extract and the fermentation product of the traditional Chinese medicine composition have wide application range, are well compatible with most of cosmetic raw materials, can be applied to various large dosage forms of cosmetics, and are simple and convenient to add.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the following detailed description is further provided in conjunction with the embodiments.
Example 1: is the application of the aqueous extract of the traditional Chinese medicine composition in the repair essence.
Preparing an aqueous extract of the traditional Chinese medicine composition: weighing 150g of radix rehmanniae recen, 150g of radix pseudostellariae, 120g of cortex dictamni, 90g of lily, 90g of liquorice, 90g of cortex moutan, 50g of semen oroxyli and 50g of radix gentianae, cleaning, packaging with a sterilized gauze bag, placing in a vacuum homogenizing emulsifying pot, adding 10 times of pure water according to the weight of the traditional Chinese medicine composition, extracting for 1 hour at 95-100 ℃, filtering and taking the medicine juice to obtain the water extract of the traditional Chinese medicine composition.
The formula of the aqueous extract repair essence containing 20 wt% of the traditional Chinese medicine composition is shown in table 1:
TABLE 1
The components of the formulation of table 1 were prepared according to the following process:
(1) firstly, weighing all the components according to the component names and the weight in the table and putting the components into a stirring pot;
(2) mixing and stirring the 8 components in the phase A until the components are completely dissolved;
(3) stirring and adding the phase B until all the components are uniformly mixed and completely dissolved, and discharging.
Example 2: is the application of the water extract of the traditional Chinese medicine composition in the repair cream.
Preparing an aqueous extract of the traditional Chinese medicine composition: weighing 250g of radix rehmanniae recen, 250g of radix pseudostellariae, 200g of cortex dictamni, 150g of lily, 150g of liquorice, 150g of cortex moutan, 100g of semen oroxyli and 100g of radix gentianae, cleaning, packaging with a sterilized gauze bag, putting into a vacuum homogenizing emulsifying pot, adding 10 times of pure water according to the weight of the traditional Chinese medicine composition, extracting for 1 hour at 95-100 ℃, filtering and taking the medicine juice to obtain the water extract of the traditional Chinese medicine composition.
The formula of the aqueous extract repair cream containing 15 wt% of the traditional Chinese medicine composition is shown in table 2:
TABLE 2
The components of the formulation of table 2 were prepared according to the following process:
(1) firstly, weighing each component according to the component names and the weight in the table;
(2) mixing the phase A components, heating to 82 ℃, and uniformly stirring;
(3) mixing and stirring the components of the phase B until the components are completely dissolved, and heating to 82 ℃;
(4) adding phase B into phase A, homogenizing in vacuum emulsifying pot at 3000rmp for 5min, stirring, cooling to 40 deg.C, and discharging.
Example 3: is the application of the traditional Chinese medicine composition in repairing emulsion.
Preparing an aqueous extract of the traditional Chinese medicine composition: weighing 200g of radix rehmanniae recen, 200g of radix pseudostellariae, 160g of cortex dictamni, 130g of lily, 130g of liquorice, 110g of cortex moutan, 70g of semen oroxyli and 70g of radix gentianae, cleaning, packaging with a sterilized gauze bag, putting into a vacuum homogenizing emulsifying pot, adding 10 times of pure water according to the weight of the traditional Chinese medicine composition, extracting for 1 hour at 95-100 ℃, filtering and taking the medicine juice to obtain the water extract of the traditional Chinese medicine composition.
The formula of the aqueous extract repair emulsion containing 25 wt% of the traditional Chinese medicine composition is shown in table 3:
TABLE 3
The components of the formulation of table 3 were prepared according to the following process:
(1) firstly, weighing each component according to the component names and the weight in the table;
(2, mixing the components of the phase A, heating to 82 ℃, and uniformly stirring;
(3) mixing and stirring the components of the phase B until the components are completely dissolved, and heating to 82 ℃;
(4) adding phase B into phase A, homogenizing in vacuum emulsifying pot at 3000rmp for 5min, stirring, cooling to 40 deg.C, and discharging.
The efficacy of examples 1 to 3 is as follows:
in the embodiments 1 to 3, the data obtained by observing and recording 180 testers are as follows:
(1) the age of 180 testers ranges from 12 to 66 years, wherein 21 testers are male, and 159 testers are female. The skin is divided into three skin types according to the sequence of the damaged degree of the skin cuticle from weak to strong, wherein 45 people occasionally have the phenomena of slight stabbing pain, burning and the like on the face in the daily skin care process, and the skin is I type skin; 63 of the skin care products can often cause phenomena of facial stabbing pain, burning and the like in the daily skin care process, and are II-type skins; among them, 72 people had severe facial stinging, burning, etc., and they were type III skin. The above individuals of each skin type were equally divided into A, B, C groups: group a used the repair serum prepared in example 1; group B repair cream prepared using example 2; group C the repair emulsion prepared in example 3 was used.
(2) The using method comprises the following steps: the product of the invention is taken to be used for twenty days respectively in the morning and at night after the face is cleaned.
(3) Effect judgment standard:
and (3) healing: the subjective symptoms disappear completely;
the effect is shown: the subjective symptoms largely disappear or are obviously relieved;
the method has the following advantages: improvement of subjective symptoms or partial disappearance of symptoms;
and (4) invalidation: no change, or no apparent change in subjective symptoms.
And (3) test results:
table 4: group a the repairing effect of the repairing essence prepared in example 1 on the stratum corneum of skin is as follows:
| skin type | Number of people | Recovery method | Show effect | Is effective | Invalidation | Recovery rate + significant efficiency |
| Type I skin | 15 | 10 | 2 | 3 | 0 | 80.0％ |
| Type II skin | 21 | 4 | 12 | 3 | 2 | 76.2％ |
| Type III skin | 24 | 2 | 9 | 10 | 3 | 45.8％ |
Table 5: group B the repairing effect of the repairing cream prepared in example 2 on the stratum corneum of skin is as follows:
| skin type | Number of people | Recovery method | Show effect | Is effective | Invalidation | Recovery rate + significant efficiency |
| Type I skin | 15 | 6 | 4 | 4 | 1 | 66.70％ |
| Type II skin | 21 | 2 | 11 | 5 | 3 | 61.9％ |
| Type III skin | 24 | 1 | 8 | 11 | 4 | 37.5％ |
Table 6: group C the repairing effect of the repairing emulsion prepared in example 3 on the stratum corneum of the skin is as follows:
| skin type | Number of people | Recovery method | Show effect | Is effective | Invalidation | Recovery rate + significant efficiency |
| Type I skin | 15 | 9 | 2 | 3 | 1 | 73.3％ |
| Type II skin | 21 | 6 | 12 | 3 | 1 | 85.7％ |
| Type III skin | 24 | 3 | 11 | 8 | 2 | 58.3％ |
Conclusion 1: the aqueous extract of the traditional Chinese medicine composition has obvious effects of repairing and relieving phenomena of skin stabbing pain, burning and the like when being applied to cosmetics.
Conclusion 2: aiming at the use conditions of people with slightly damaged skin cuticle, namely I-type skin, moderately damaged skin, namely II-type skin and severely damaged skin, namely III-type skin, the three cosmetics prepared in the embodiments 1 to 3 can achieve really effective repairing efficacy, and the cure rate and the significant efficiency are 37.5 percent at the lowest and 85.7 percent at the highest.
Example 4: is the application of the traditional Chinese medicine fermentation product in the repair essence.
Preparing a traditional Chinese medicine fermentation product: weighing 150g of radix rehmanniae recen, 150g of radix pseudostellariae, 120g of cortex dictamni, 90g of lily, 90g of liquorice, 90g of cortex moutan, 50g of semen oroxyli and 50g of radix gentianae, cleaning, placing in a fermentation tank, adding 90g of high-activity dry yeast and 10 times of pure water, fermenting for 4 hours at 42 ℃ and 0rpm, sterilizing, filtering to obtain filtrate, and obtaining the traditional Chinese medicine fermentation product.
The formula of the repair essence containing 20 wt% of the fermented product of the traditional Chinese medicine is shown in table 7:
TABLE 7
The components of the formulation of table 7 were prepared according to the following procedure:
(1) firstly, weighing all the components according to the component names and the weight in the table and putting the components into a stirring pot;
(2) mixing and stirring the 8 components in the phase A until the components are completely dissolved;
(3) stirring and adding the phase B until all the components are uniformly mixed and completely dissolved, and discharging.
Example 5: is the application of Chinese medicinal fermented product in repairing cream.
Preparing a traditional Chinese medicine fermentation product: weighing 250g of radix rehmanniae recen, 250g of radix pseudostellariae, 200g of cortex dictamni, 150g of lily, 150g of liquorice, 150g of cortex moutan, 100g of semen oroxyli and 100g of radix gentianae, cleaning, placing in a fermentation tank, adding 250g of high-activity dry yeast and 10 times of pure water, fermenting for 8 hours at 36 ℃ and 10rpm, sterilizing, filtering to obtain filtrate, and obtaining the traditional Chinese medicine fermentation product.
The formula of the repair cream containing 15 wt% of the fermented product of the traditional Chinese medicine is shown in table 8:
TABLE 8
The components of the formulation of table 8 were prepared according to the following procedure:
(1) firstly, weighing each component according to the component names and the weight in the table;
(2) mixing the phase A components, heating to 82 ℃, and uniformly stirring;
(3) mixing and stirring the components of the phase B until the components are completely dissolved, and heating to 82 ℃;
(4) adding phase B into phase A, homogenizing in vacuum emulsifying pot at 3000rmp for 5min, stirring, cooling to 40 deg.C, and discharging.
Example 6: is the application of Chinese medicine leavening in repairing emulsion.
Preparing a traditional Chinese medicine fermentation product: weighing 200g of radix rehmanniae recen, 200g of radix pseudostellariae, 160g of cortex dictamni, 130g of lily, 130g of liquorice, 110g of cortex moutan, 70g of semen oroxyli and 70g of radix gentianae, cleaning, placing in a fermentation tank, adding 150g of high-activity dry yeast and 10 times of pure water, fermenting for 24 hours at the temperature of 28 ℃ and at the speed of 5rpm, sterilizing, filtering to obtain filtrate, and obtaining the traditional Chinese medicine fermentation product.
The formula of the repair emulsion containing 25 wt% of the fermented product of the traditional Chinese medicine is shown in table 9:
TABLE 9
Table 9 the ingredients in the formulation were prepared according to the following process:
(1) firstly, weighing each component according to the component names and the weight in the table;
(2, mixing the components of the phase A, heating to 82 ℃, and uniformly stirring;
(3) mixing and stirring the components of the phase B until the components are completely dissolved, and heating to 82 ℃;
(4) adding phase B into phase A, homogenizing in vacuum emulsifying pot at 3000rmp for 5min, stirring, cooling to 40 deg.C, and discharging.
The efficacy of examples 4 to 6 is as follows:
in the embodiments 4-6, the data obtained by observing and recording 165 testers are as follows:
(1) the age of 165 testers ranges from 13 to 68 years, wherein 15 testers are male, and 150 testers are female. The skin is divided into three skin types according to the sequence of the damaged degree of the skin cuticle from weak to strong, wherein 36 people occasionally have the phenomena of slight stabbing pain, burning and the like on the face in the daily skin care process, and the skin is type I skin; wherein 66 people can often have phenomena of facial stabbing pain, burning and the like in the daily skin care process, and the skin is type II skin; of these 63 people had severe facial stinging, burning, etc. and were type III skin. The above individuals of each skin type were equally divided into A, B, C groups: group a used the repair serum prepared in example 4; group B the repair cream prepared in example 5 was used; group C the repair emulsion prepared in example 6 was used.
(2) The using method comprises the following steps: the product of the invention is taken to be used for twenty days respectively in the morning and at night after the face is cleaned.
(3) Effect judgment standard:
and (3) healing: the subjective symptoms disappear completely;
the effect is shown: the subjective symptoms largely disappear or are obviously relieved;
the method has the following advantages: improvement of subjective symptoms or partial disappearance of symptoms;
and (4) invalidation: no change, or no apparent change in subjective symptoms.
And (3) test results:
table 10: group a the repairing effect of the repairing essence prepared in example 4 on the stratum corneum of skin is as follows:
| skin type | Number of people | Recovery method | Show effect | Is effective | Invalidation | Recovery rate + significant efficiency |
| Type I skin | 12 | 11 | 0 | 1 | 0 | 91.7％ |
| Type II skin | 22 | 6 | 12 | 4 | 0 | 81.8％ |
| Type III skin | 21 | 4 | 12 | 3 | 2 | 76.2％ |
Table 11: group B the repairing effect of the repairing cream prepared in example 5 on the stratum corneum of skin is as follows:
| skin type | Number of people | Recovery method | Show effect | Is effective | Invalidation | Recovery rate + significant efficiency |
| Type I skin | 12 | 7 | 2 | 2 | 1 | 75.0％ |
| Type II skin | 22 | 5 | 11 | 6 | 0 | 72.7％ |
| Type III skin | 21 | 4 | 8 | 9 | 0 | 57.1％ |
Table 12: group C the repairing effect on the stratum corneum of the skin using the repairing emulsion prepared in example 6 is as follows:
| skin type | Number of people | Recovery method | Show effect | Is effective | Invalidation | Recovery rate + significant efficiency |
| Type I skin | 12 | 8 | 2 | 1 | 1 | 83.3％ |
| Type II skin | 22 | 8 | 6 | 6 | 2 | 63.6％ |
| Type III skin | 21 | 3 | 10 | 8 | 0 | 61.9％ |
Conclusion 1: the traditional Chinese medicine fermentation product has obvious effects of repairing and relieving phenomena of skin stabbing pain, burning and the like when being applied to cosmetics.
Conclusion 2: aiming at the use conditions of people with slightly damaged skin cuticle, namely I-type skin, moderately damaged skin, namely II-type skin and severely damaged skin, namely III-type skin, the three cosmetics prepared in the embodiments 4 to 6 can achieve really effective repairing efficacy, and the cure rate and the significant efficiency are 57.1 percent at the lowest and 91.7 percent at the highest.
The names of the cosmetic ingredients according to examples 1 to 6 are listed in the catalog of names of used cosmetic ingredients issued by the State food and drug administration (2015 edition).
In the above embodiments, the Chinese medicinal composition is a crude medicinal material or a Chinese medicinal decoction piece. A Chinese medicinal composition with skin cuticle repairing effect and its fermented product and application are provided, which comprises water extract of Chinese medicinal composition and Chinese medicinal fermented product, and their preparation, and application in preparing medicine or cosmetic with skin cuticle repairing, moisturizing, antiinflammatory, antiallergic, and itching relieving effects.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. A traditional Chinese medicine composition with the effect of repairing skin cuticle comprises the following components in parts by mass: 150-250 parts of radix rehmanniae recen, 150-250 parts of radix pseudostellariae, 120-200 parts of cortex dictamni, 90-150 parts of lily, 90-150 parts of liquorice, 90-150 parts of cortex moutan, 50-100 parts of oroxylum indicum and 50-100 parts of gentian.
2. The traditional Chinese medicine composition with the effect of repairing the skin stratum corneum as claimed in claim 1, wherein the mass fraction specifically consists of the following components: 150 parts of radix rehmanniae recen, 150 parts of radix pseudostellariae, 120 parts of cortex dictamni, 90 parts of lily, 90 parts of liquorice, 90 parts of cortex moutan, 50 parts of oroxylum indicum and 50 parts of gentian.
3. The traditional Chinese medicine composition with the effect of repairing the skin stratum corneum as claimed in claim 1, wherein the mass fraction specifically consists of the following components: 250 parts of radix rehmanniae recen, 250 parts of heterophylly falsestarwort root, 200 parts of dittany bark, 150 parts of lily, 150 parts of liquorice, 150 parts of tree peony bark, 100 parts of oroxylum indicum and 100 parts of gentian.
4. The traditional Chinese medicine composition with the effect of repairing the skin stratum corneum as claimed in claim 1, wherein the mass fraction specifically consists of the following components: 200 parts of radix rehmanniae recen, 200 parts of radix pseudostellariae, 160 parts of cortex dictamni, 130 parts of lily, 130 parts of liquorice, 110 parts of moutan bark, 70 parts of oroxylum indicum and 70 parts of gentian root.
5. The aqueous extract of the Chinese medicinal composition with the effect of repairing skin horny layer according to any one of claims 1 to 4 is a filtrate prepared by adding 10 times of pure water by weight to the Chinese medicinal composition, extracting the mixture in a vacuum homogenizing emulsifying pot at 95-100 ℃ for 1 hour, and filtering.
6. The fermented product of the Chinese medicinal composition for repairing skin horny layer according to any one of claims 1 to 4, which is a filtrate obtained by adding 10 times of pure water by weight to an initial system obtained by mixing the Chinese medicinal composition and fermentation tubes, and sterilizing and filtering the fermented liquid obtained by fermentation.
7. The fermented product of the traditional Chinese medicine composition with the effect of repairing the skin cuticle of claim 6, wherein the fermentation bacteria are saccharomycetes, and the traditional Chinese medicine composition is added into the fermented product in a form of high-activity dry yeast according to 90-250 parts by mass.
8. The fermented product of the traditional Chinese medicine composition with the effect of repairing the skin cuticle of claim 6, wherein in the fermentation step, the temperature is 25-45 ℃; the stirring speed is 0-50 rpm; the time is 4-24 h.
9. Use of an aqueous extract of a Chinese medicinal composition for repairing skin stratum corneum, according to claim 5, in the preparation of a cosmetic for repairing skin stratum corneum, wherein the aqueous extract is incorporated into the cosmetic in an amount of 1-60 wt%.
10. Use of a fermented product of the Chinese medicinal composition for repairing skin stratum corneum according to any one of claims 6 to 8 in the preparation of a cosmetic having skin stratum corneum repairing effect, wherein the fermented product is incorporated into the cosmetic in an amount of 1 to 60 wt%.
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