CN114010565B - Whitening and freckle-removing composition, and preparation method and application thereof - Google Patents
Whitening and freckle-removing composition, and preparation method and application thereof Download PDFInfo
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- CN114010565B CN114010565B CN202111451366.7A CN202111451366A CN114010565B CN 114010565 B CN114010565 B CN 114010565B CN 202111451366 A CN202111451366 A CN 202111451366A CN 114010565 B CN114010565 B CN 114010565B
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 61
- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000000284 extract Substances 0.000 claims abstract description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 claims abstract description 28
- 229940067599 ascorbyl glucoside Drugs 0.000 claims abstract description 28
- BJRNKVDFDLYUGJ-ZIQFBCGOSA-N alpha-Arbutin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-ZIQFBCGOSA-N 0.000 claims abstract description 27
- 229940033280 alpha-arbutin Drugs 0.000 claims abstract description 27
- 239000001649 glycyrrhiza glabra l. absolute Substances 0.000 claims abstract description 26
- 235000020725 licorice root extract Nutrition 0.000 claims abstract description 26
- 229940051810 licorice root extract Drugs 0.000 claims abstract description 26
- 229940074122 phyllanthus emblica fruit extract Drugs 0.000 claims abstract description 22
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 18
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 18
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 18
- 239000002537 cosmetic Substances 0.000 claims abstract description 16
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 11
- 239000002085 irritant Substances 0.000 claims abstract description 11
- 241001071795 Gentiana Species 0.000 claims description 46
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 34
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical group CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 30
- 241000405414 Rehmannia Species 0.000 claims description 18
- 235000005152 nicotinamide Nutrition 0.000 claims description 17
- 229960003966 nicotinamide Drugs 0.000 claims description 17
- 239000011570 nicotinamide Substances 0.000 claims description 17
- 238000003756 stirring Methods 0.000 claims description 17
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 15
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 15
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 15
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 14
- 244000119298 Emblica officinalis Species 0.000 claims description 6
- 235000015489 Emblica officinalis Nutrition 0.000 claims description 6
- 239000003906 humectant Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 241001530056 Athelia rolfsii Species 0.000 claims description 5
- 229920005862 polyol Polymers 0.000 claims description 5
- 150000003077 polyols Chemical class 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 2
- 229960004063 propylene glycol Drugs 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- 241001558929 Sclerotium <basidiomycota> Species 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 11
- 230000003020 moisturizing effect Effects 0.000 abstract description 11
- 230000001988 toxicity Effects 0.000 abstract description 7
- 231100000419 toxicity Toxicity 0.000 abstract description 7
- 239000009609 fructus phyllanthi Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 32
- 230000000052 comparative effect Effects 0.000 description 27
- 230000002829 reductive effect Effects 0.000 description 23
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 20
- 239000000047 product Substances 0.000 description 20
- 238000012360 testing method Methods 0.000 description 16
- 239000008367 deionised water Substances 0.000 description 13
- 229910021641 deionized water Inorganic materials 0.000 description 13
- 239000012467 final product Substances 0.000 description 8
- 210000002752 melanocyte Anatomy 0.000 description 6
- 208000003251 Pruritus Diseases 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 230000001804 emulsifying effect Effects 0.000 description 4
- 230000002110 toxicologic effect Effects 0.000 description 4
- 231100000759 toxicological effect Toxicity 0.000 description 4
- 230000007803 itching Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000002780 melanosome Anatomy 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010059516 Skin toxicity Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- 230000003851 biochemical process Effects 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000019000 darkening of skin Diseases 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 229940068517 fruit extracts Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 231100000438 skin toxicity Toxicity 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The application discloses a whitening and freckle-removing composition, and a preparation method and application thereof, and relates to the field of cosmetics. The composition comprises radix rehmanniae extract, hydrolyzed sclerotium gum, acetylated hyaluronic acid, nicotinamide, alpha-arbutin, ascorbyl glucoside, glycyrrhrizae radix extract, radix Gentianae anti-irritant factor, fructus Phyllanthi extract and water. The application combines the effects of each component, and simultaneously strictly controls the addition content of components such as nicotinamide, alpha-arbutin, ascorbyl glucoside, licorice root extract, phyllanthus emblica fruit extract and the like, plays a role of synergy, strictly limits the components and the content in the composition, and can ensure that the whitening and moisturizing performances of the product are improved to the greatest extent on the premise of reducing the toxicity to skin.
Description
Technical Field
The application relates to the field of cosmetics, in particular to a whitening and freckle-removing composition, and a preparation method and application thereof.
Background
Fair skin is a pursuit of many women siblings, however, facial skin tends to darken in complexion, stains, etc. with age. In order to keep the skin whitening, people choose to adopt a whitening product or an operation mode to carry out corresponding treatment on the skin, and the improvement of skin color is often accompanied with the removal of freckles in the whitening process, wherein the operation mode has great damage to the skin and irreversibility, and is gradually abandoned by people, and the whitening product is more and more enthusiastic for people.
In the investigation of skin complexion and stains, melanin is a factor that cannot be used for darkening the complexion, stains, and the like. The melanin formation process of the skin comprises a series of complex physiological and biochemical processes such as migration of melanocytes, division and maturation of melanocytes, formation of melanosomes, running of melanin granules and excretion of melanin. Melanin is generally considered to be synthesized by catalyzing the amino acid-containing channel and collateral amino acid enzyme on melanosomes in melanocytes, and the process of oxidizing the amino acid into melanin is relatively complex, and under the influence of ultraviolet rays, living pressure, age-related factors and the like, the activity of the amino acid-containing channel and collateral amino acid enzyme and the activity of the melanocytes can be enhanced, so that the oxidation can be promoted, the synthesis and deposition speed of the melanin can be accelerated, the pigmentation of the original pigment can be deepened, and the skin darkening and the formation of color spots can be caused. Therefore, in research on whitening and freckle-removing products of skin, the skin needs to be thoroughly repaired from the viewpoint of a plurality of causative mechanisms such as darkening of skin color, color spots and the like.
At present, most of the whitening and freckle-removing products on the market have poor multiple effects, and cannot realize high-efficiency whitening and freckle removal. Meanwhile, in order to pursue whitening efficacy, the existing whitening and freckle removing products are added with substances with strong toxicity such as mercury, hydroquinone preparations and the like, have large side effects, are easy to induce other skin diseases, can cause irreversible damage to skin, and are not beneficial to nursing healthy skin.
Disclosure of Invention
The application provides a whitening and freckle-removing composition, and a preparation method and application thereof, which are used for solving the technical problems of insufficient whitening effect and strong skin toxicity of the existing whitening products.
In order to solve the technical problems, one of the purposes of the application is to provide a whitening and freckle removing composition which comprises the following raw materials in parts by weight:
rehmannia root extract: 0.02-0.2 parts;
hydrolyzed sclerotium rolfsii: 0.01 to 0.2 parts;
acetylated hyaluronic acid: 0.03-0.3 parts;
nicotinamide: 0.2-4 parts;
alpha-arbutin: 0.15-3 parts;
ascorbyl glucoside: 0.1-2 parts;
licorice root extract: 0.2-3 parts;
gentian anti-irritant factor: 0.2-5 parts;
extract of phyllanthus emblica: 0.2-2 parts;
water: 81-98 parts.
The rehmannia root extract has good moisturizing, anti-aging and repairing effects through the combination of the effects of the components; the nicotinamide can reduce melanin which is generated and precipitated, obstruct the transfer of the melanin to surface cells, accelerate the metabolism of cells, accelerate the falling of melanocyte, maintain the water content of skin, promote the microcirculation of dermis, greatly reduce or eliminate the aging phenomenon of skin, reduce the damage of free radicals to the skin, and play roles in preventing aging, repairing the skin and reducing facial darkness; arbutin can inhibit the activity of tyrosine in a concentration range without melanocyte toxicity, and block the synthesis of dopa and dopaquinone, thereby inhibiting the generation of melanin; the ascorbyl glucoside has skin brightening, antioxidant, and skin aging delaying effects. Meanwhile, the addition amount ranges of nicotinamide, alpha-arbutin, ascorbyl glucoside, licorice root extract, phyllanthus emblica extract and the like are strictly controlled, the synergistic effect is exerted, the components and the content in the composition are strictly limited, and the whitening and moisturizing performances of the product are maximally improved on the premise of reducing the toxicity to the skin.
As a preferred scheme, the whitening and freckle-removing composition further comprises 0.01-0.1 part by weight of EDTA-disodium and 0.3-1 part by weight of preservative.
Preferably, the preservative is p-hydroxyacetophenone.
Preferably, the whitening and freckle-removing composition further comprises 0.3-2 parts by weight of a polyol humectant.
Preferably, the polyol humectant is one or more of 1, 2-hexanediol, propylene glycol and butylene glycol.
As a preferred scheme, the gentian anti-irritation factor is prepared from gentian extract, butanediol and water according to the mass ratio of (0.5-2): (15-30): (70-85) mixing.
In order to solve the technical problems, the second object of the present application is to provide a preparation method of a whitening and freckle-removing composition, which comprises the following steps:
s1, mixing water, a rehmannia root extract, hydrolyzed sclerotium rolfsii and acetylated hyaluronic acid uniformly;
s2, continuing to sequentially add nicotinamide, alpha-arbutin and ascorbyl glucoside, and uniformly stirring;
and S3, continuously and sequentially adding the licorice root extract, the gentian anti-irritant factors and the phyllanthus emblica fruit extract, and uniformly stirring to obtain the whitening and freckle removing composition.
As a preferable scheme, in S1, 0.01 to 0.1 parts by weight of disodium EDTA is added simultaneously, and after S3, S4 is further included, and S4 is specifically: continuously adding 0.3-2 parts by weight of polyol humectant and 0.3-1 part by weight of preservative, and uniformly stirring to finally obtain the whitening and freckle-removing composition.
Preferably, in S1, the stirring rate is 300 rpm; in S2, the stirring speed is 2000 rpm; in S3, the stirring speed is 200 rpm; in S4, the stirring rate was 150 rpm.
In order to solve the technical problems, the application provides an application of the whitening and freckle-removing composition in the field of cosmetics.
Compared with the prior art, the embodiment of the application has the following beneficial effects:
the application combines the effects of each component, and strictly controls the addition amount range of nicotinamide, alpha-arbutin, ascorbyl glucoside, licorice root extract and phyllanthus emblica fruit extract, plays a role of synergy, strictly limits the components and the content in the composition, and improves the whitening and moisturizing performances of the product to the greatest extent on the premise of reducing the toxicity to the skin.
Detailed Description
The technical solutions of the embodiments of the present application will be clearly and completely described below in conjunction with the embodiments of the present application, and it is apparent that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Example 1
A whitening and freckle-removing composition is applied to the field of cosmetics and comprises the following components in percentage by mass: EDTA disodium 0.06%, chinese rehmannia root extract 0.2%, hydrolyzed sclerotium gum 0.08%, acetylated hyaluronic acid 0.1%, nicotinamide 0.8%, alpha-arbutin 2.0%, ascorbyl glucoside 2.0%, licorice root extract 0.8%, gentian anti-irritation factor 3.5%, phyllanthus emblica fruit extract 2.0%,1, 2-hexanediol 1.6%, p-hydroxyacetophenone 0.3%, deionized water 86.56%, wherein the gentian anti-irritation factor is prepared from gentian extract, butanediol and water according to a mass ratio of 1:30: 140.
Example two
A whitening and freckle-removing composition is applied to cosmetics and comprises the following components in percentage by mass: EDTA disodium 0.05%, chinese rehmannia root extract 0.1%, hydrolyzed sclerotium gum 0.1%, acetylated hyaluronic acid 0.15%, nicotinamide 1.0%, alpha-arbutin 1.0%, ascorbyl glucoside 0.5%, licorice root extract 2.0%, gentian anti-irritation factor 1.0%, phyllanthus emblica fruit extract 0.5%,1, 2-hexanediol 0.5%, p-hydroxyacetophenone 0.5% and deionized water 92.6%, wherein the gentian anti-irritation factor is prepared from gentian extract, butanediol and water according to a mass ratio of 2:30: 85.
Example III
A whitening and freckle-removing composition is applied to the field of cosmetics and comprises the following components in percentage by mass: EDTA disodium 0.01%, chinese rehmannia root extract 0.15%, hydrolyzed sclerotium gum 0.2%, acetylated hyaluronic acid 0.03%, nicotinamide 2.5%, alpha-arbutin 0.15%, ascorbyl glucoside 1.5%, licorice root extract 0.2%, gentian anti-irritation factor 2.6%, phyllanthus emblica fruit extract 0.2%,1, 2-hexanediol 0.3%, p-hydroxyacetophenone 0.6%, deionized water 91.56%, wherein the gentian anti-irritation factor is prepared from gentian extract, butanediol and water according to a mass ratio of 1:10: 40.
Example IV
A whitening and freckle-removing composition is applied to the field of cosmetics and comprises the following components in percentage by mass: EDTA disodium 0.05%, chinese rehmannia root extract 0.02%, hydrolyzed sclerotium gum 0.05%, acetylated hyaluronic acid 0.22%, nicotinamide 4.0%, alpha-arbutin 0.6%, ascorbyl glucoside 0.1%, licorice root extract 3.0%, gentian anti-irritant factor 0.2%, phyllanthus emblica fruit extract 0.8%,1, 2-hexanediol 2.0%, p-hydroxyacetophenone 1.0%, deionized water 87.96%, wherein the gentian anti-irritant factor is prepared from gentian extract, butanediol and water according to a mass ratio of 2:30: 85.
Example five
A whitening and freckle-removing composition is applied to the field of cosmetics and comprises the following components in percentage by mass: EDTA disodium 0.1%, chinese rehmannia root extract 0.06%, hydrolyzed sclerotium gum 0.01%, acetylated hyaluronic acid 0.3%, nicotinamide 0.2%, alpha-arbutin 3.0%, ascorbyl glucoside 1.0%, licorice root extract 1.6%, gentian anti-irritation factor 5.0%, phyllanthus emblica fruit extract 1.2%,1, 2-hexanediol 1.0%, p-hydroxyacetophenone 0.5%, deionized water 86.03%, wherein the gentian anti-irritation factor is prepared from gentian extract, butanediol and water according to a mass ratio of 1:30: 140.
Comparative example one
A whitening and freckle-removing composition is applied to the field of cosmetics and comprises the following components in percentage by mass: EDTA disodium 0.05%, chinese rehmannia root extract 0.1%, hydrolyzed sclerotium gum 0.1%, acetylated hyaluronic acid 0.15%, nicotinamide 1.0%, alpha-arbutin 0.05%, ascorbyl glucoside 3.0%, licorice root extract 2.0%, gentian anti-irritation factor 2.0%, phyllanthus emblica fruit extract 0.1%,1, 2-hexanediol 0.5%, p-hydroxyacetophenone 0.5% and deionized water 90.45%, wherein the gentian anti-irritation factor is prepared from gentian extract, butanediol and water according to a mass ratio of 2:30: 85.
Comparative example two
A whitening and freckle-removing composition is applied to the field of cosmetics and comprises the following components in percentage by mass: EDTA disodium 0.05%, chinese rehmannia root extract 0.1%, hydrolyzed sclerotium gum 0.1%, acetylated hyaluronic acid 0.15%, nicotinamide 0.1%, alpha-arbutin 1.0%, ascorbyl glucoside 0.05%, licorice root extract 5.0%, gentian anti-irritation factor 1.0%, phyllanthus emblica fruit extract 0.05%,1, 2-hexanediol 0.5%, p-hydroxyacetophenone 0.5% and deionized water 91.4%, wherein the gentian anti-irritation factor is prepared from gentian extract, butanediol and water according to a mass ratio of 2:30: 85.
Comparative example three
A whitening and freckle-removing composition is applied to the field of cosmetics and comprises the following components in percentage by mass: EDTA disodium 0.05%, chinese rehmannia root extract 0.1%, hydrolyzed sclerotium gum 0.1%, acetylated hyaluronic acid 0.15%, nicotinamide 5.0%, alpha-arbutin 4.0%, ascorbyl glucoside 0.05%, licorice root extract 2.0%, gentian anti-irritation factor 1.0%, phyllanthus emblica fruit extract 0.5%,1, 2-hexanediol 0.5%, p-hydroxyacetophenone 0.5% and deionized water 86.05, wherein the gentian anti-irritation factor is prepared from gentian extract, butanediol and water according to a mass ratio of 2:30: 85.
Comparative example four
A whitening and freckle-removing composition is applied to the field of cosmetics and comprises the following components in percentage by mass: EDTA disodium 0.05%, chinese rehmannia root extract 0.1%, hydrolyzed sclerotium gum 0.1%, acetylated hyaluronic acid 0.15%, nicotinamide 0.08%, alpha-arbutin 0.08%, ascorbyl glucoside 0.5%, licorice root extract 0.1%, gentian anti-irritation factor 1.0%, phyllanthus emblica fruit extract 4.0%,1, 2-hexanediol 0.5%, p-hydroxyacetophenone 0.5% and deionized water 92.84%, wherein the gentian anti-irritation factor is prepared from gentian extract, butanediol and water according to a mass ratio of 2:30: 85.
Comparative example five
A whitening and freckle-removing composition is applied to the field of cosmetics and comprises the following components in percentage by mass: EDTA disodium 0.05%, chinese rehmannia root extract 0.1%, hydrolyzed sclerotium gum 0.1%, acetylated hyaluronic acid 0.15%, nicotinamide 5.5%, alpha-arbutin 1.0%, ascorbyl glucoside 4.0%, licorice root extract 0.05%, gentian anti-irritant factor 1.0%, phyllanthus emblica fruit extract 3.0%,1, 2-hexanediol 0.5%, p-hydroxyacetophenone 0.5%, deionized water 84.05%, wherein the gentian anti-irritant factor is prepared from gentian extract, butanediol and water according to a mass ratio of 2:30: 85.
Comparative example six
A whitening and freckle-removing composition is applied to the field of cosmetics and comprises the following components in percentage by mass: EDTA disodium 0.05%, chinese rehmannia root extract 0.1%, hydrolyzed sclerotium gum 0.1%, acetylated hyaluronic acid 0.15%, nicotinamide 0.02%, alpha-arbutin 0.1%, ascorbyl glucoside 0.04%, licorice root extract 0.02%, gentian anti-irritation factor 1.0%, phyllanthus emblica fruit extract 3.5%,1, 2-hexanediol 0.5%, p-hydroxyacetophenone 0.5%, deionized water 93.92%, wherein the gentian anti-irritation factor is prepared from gentian extract, butanediol and water according to a mass ratio of 2:30: 85.
Comparative example seven
A whitening and freckle-removing composition is applied to the field of cosmetics and comprises the following components in percentage by mass: EDTA disodium 0.05%, chinese rehmannia root extract 0.1%, hydrolyzed sclerotium gum 0.1%, acetylated hyaluronic acid 0.15%, nicotinamide 0.05%, alpha-arbutin 3.5%, ascorbyl glucoside 2.5%, licorice root extract 4.0%, gentian anti-irritation factor 1.0%, phyllanthus emblica fruit extract 0.04%,1, 2-hexanediol 0.5%, p-hydroxyacetophenone 0.5%, deionized water 87.51%, wherein the gentian anti-irritation factor is prepared from gentian extract, butanediol and water according to a mass ratio of 2:30: 85.
The preparation method of the whitening and freckle removing composition in the above examples 1-5 and comparative examples 1-7 comprises the following steps:
s1, adding deionized water into an emulsifying pot, starting stirring (300 revolutions per minute), sequentially adding EDTA disodium, chinese rehmannia root extract, hydrolyzed sclerotium rolfsii and acetylated hyaluronic acid, homogenizing at a low speed (1000 revolutions per minute), and carrying out about 2-3 minutes until the mixture is completely and uniformly dispersed;
s2, sequentially adding nicotinamide, alpha-arbutin and ascorbyl glucoside into an emulsifying pot, homogenizing at a medium speed (2000 rpm) for about 2 minutes until the mixture is uniformly dispersed;
s3, sequentially adding the licorice root extract, the gentian anti-irritant factors and the phyllanthus emblica fruit extract into an emulsifying pot, and stirring (200 rpm) for 10 minutes until the licorice root extract, the gentian anti-irritant factors and the phyllanthus emblica fruit extract are completely and uniformly dispersed;
s4, sequentially adding 1, 2-hexanediol and p-hydroxyacetophenone into an emulsifying pot, and stirring (150 rpm) for 5 minutes until the mixture is completely and uniformly dispersed;
s5, sampling, and discharging after the detection is qualified.
Performance test
1. Physical and chemical property test: the physical and chemical properties of the whitening and freckle-removing compositions of examples 1 to 5 and comparative examples 1 to 7 were tested for cold and heat resistance, and the test results are shown in table 1.
TABLE 1 appearance states of examples 1-5 and comparative examples 1-7 and corresponding performance test results
2. Use of test
Test sample: whitening and freckle-removing compositions of examples 1 to 5 and comparative examples 1 to 7;
test population: 60 female staff on the production line, 25-40 years old, no skin disease allergy history and skin health;
the testing method comprises the following steps: the testers were randomly divided into 12 groups of 5 persons, each group was respectively and correspondingly used with the whitening and freckle-removing compositions of examples 1-5 and comparative examples 1-7, the hands were cleaned before each use, 3.0+ -0.5 g of the corresponding whitening and freckle-removing composition sample was taken and smeared on the face, and the application was uniform, and each time in the morning and evening was used for 8 weeks continuously. If the discomfort symptoms such as itch, burning, redness and the like of the skin occur for more than 2 times continuously in the middle, the use of the corresponding sample is stopped, and the test of the corresponding sample is finished.
And observing the comparison of the front skin and the rear skin of the sample used by the subject, grading the whitening and freckle removing test results, carrying out statistics average division on the same group in a full scale of 10 minutes, wherein the higher the score is, the better the effect is. Meanwhile, sensitization (irritation including uncomfortable symptoms such as itching, burning, redness and the like) and skin feel and moisturizing effect are evaluated according to experience of a subject, wherein the moisturizing effect is prepared by scoring. The test results are shown in table 2 below.
TABLE 2 post-use sensory evaluation results for examples 1-5 and comparative examples 1-7
As can be seen from the results of the tests of examples 1 to 5 and comparative example 1 in tables 1 to 2, the addition amount of α -arbutin and phyllanthus emblica fruit extract is reduced in comparative example 1, and the content of ascorbyl glucoside is increased, so that the temperature balance of the final composition is destroyed, and the finally obtained composition is easy to generate layering phenomenon under the condition of large temperature variation range; the final product has obvious toxicological effect on skin, thereby causing damage such as skin reddening, and the moisture retention and whitening performance of the product can not meet the standard requirements due to insufficient addition of the alpha-arbutin and phyllanthus emblica fruit extracts, and the performance is wholly reduced.
As can be seen from the results of the test of examples 1-5 and comparative example 2 in tables 1-2, the addition amount of nicotinamide, ascorbyl glucoside and phyllanthus emblica fruit extract is reduced in comparative example 2, which results in reduced moisturizing and whitening properties of the product, and the addition amount of licorice root extract is increased, so that the viscosity of the composition is improved, a sticky use feeling is generated, the temperature resistance of the final product is influenced, and the cold resistance is remarkably reduced.
As can be seen from the results of the tests of examples 1-5 and comparative example 3 in tables 1-2, the addition amount of ascorbyl glucoside is reduced in comparative example 3, so that the moisturizing and whitening properties of the product are reduced, the addition amounts of nicotinamide and alpha-arbutin are increased, the toxicity of the final product to the skin is obvious, the skin is slightly itchy, the heat resistance and cold resistance of the product are reduced, and the stability is reduced.
As can be seen from the results of the tests of examples 1-5 and comparative example 4 in tables 1-2, the addition amount of nicotinamide, alpha-arbutin and licorice root extract is reduced in comparative example 4, so that the moisturizing and whitening properties of the product are reduced, the addition amount of phyllanthus emblica extract is increased, the toxicological effect of the final product on skin is obvious, a slight redness phenomenon occurs, the cold resistance of the product is obviously reduced, and the stability is reduced.
As can be seen from the results of the tests of examples 1-5 and comparative example 5 in tables 1-2, the addition amount of the licorice root extract is reduced in comparative example 5, and the addition amounts of nicotinamide, ascorbyl glucoside and phyllanthus emblica fruit extract are increased at the same time, so that the final product has a slightly sticky problem, has obvious toxicological effects on skin, and thus has the symptom of slight itching of skin; in addition, the cold resistance of the final product is significantly reduced and the stability is reduced.
As can be seen from the results of the tests of examples 1-5 and comparative example 6 in tables 1-2, the addition amount of nicotinamide, alpha-arbutin, ascorbyl glucoside and licorice root extract is reduced in comparative example 6, so that the whitening and moisturizing performances of the product are reduced, the addition amount of the phyllanthus emblica extract is improved, the toxicological effect of the final product on skin is obvious, the symptom of slight redness appears, and the product is greasy and difficult to absorb; in addition, the heat resistance and cold resistance of the product are obviously reduced, delamination is easy to occur under the condition of large temperature change range, and the stability is reduced.
As can be seen from the results of the tests of examples 1-5 and comparative example 7 in tables 1-2, comparative example 7 reduced the addition of nicotinamide and phyllanthus emblica fruit extract, so that the whitening and moisturizing properties of the product were reduced, and the addition of alpha-arbutin, ascorbyl glucoside and licorice root extract was increased, and the toxicity of the final product to the skin was more pronounced, and slight itching symptoms appeared, the greasy use feel of the product was poor, and the temperature resistance of the product was reduced and the stability was poor.
The foregoing embodiments have been provided for the purpose of illustrating the general principles of the present application, and are not to be construed as limiting the scope of the application. It should be noted that any modifications, equivalent substitutions, improvements, etc. made by those skilled in the art without departing from the spirit and principles of the present application are intended to be included in the scope of the present application.
Claims (7)
1. The whitening and freckle-removing composition is characterized by comprising the following raw materials in parts by weight:
rehmannia root extract: 0.02-0.2 parts;
hydrolyzed sclerotium rolfsii: 0.01 to 0.2 parts;
acetylated hyaluronic acid: 0.03-0.3 parts;
nicotinamide: 0.2-4 parts;
alpha-arbutin: 0.15-3 parts;
ascorbyl glucoside: 0.1-2 parts;
licorice root extract: 0.2-3 parts;
gentian anti-irritant factor: 0.2-5 parts;
extract of phyllanthus emblica: 0.2-2 parts;
water: 81-98 parts;
the whitening and freckle-removing composition also comprises 0.01 to 0.1 part by weight of EDTA-disodium and 0.3 to 1 part by weight of preservative; the whitening and freckle-removing composition also comprises 0.3-2 parts by weight of a polyol humectant; the gentian anti-irritation factor is prepared from gentian extract, butanediol and water according to the mass ratio of (0.5-2): (15-30): (70-85) mixing.
2. The whitening and freckle removing composition according to claim 1, wherein the preservative is p-hydroxyacetophenone.
3. The whitening and freckle-removing composition of claim 1, wherein the polyhydric alcohol humectant is one or more of 1, 2-hexanediol, propylene glycol and butylene glycol.
4. A method for preparing a whitening and freckle-removing composition according to any one of claims 1 to 3, comprising the steps of:
s1, mixing water, a rehmannia root extract, hydrolyzed sclerotium rolfsii and acetylated hyaluronic acid uniformly;
s2, continuing to sequentially add nicotinamide, alpha-arbutin and ascorbyl glucoside, and uniformly stirring;
and S3, continuously and sequentially adding the licorice root extract, the gentian anti-irritant factors and the phyllanthus emblica fruit extract, and uniformly stirring to obtain the whitening and freckle removing composition.
5. The method for preparing a whitening and freckle-removing composition according to claim 4, wherein in S1, 0.01 to 0.1 parts by weight of disodium EDTA is added simultaneously, and after S3, S4 is further included, wherein S4 is specifically: continuously adding 0.3-2 parts by weight of polyol humectant and 0.3-1 part by weight of preservative, and uniformly stirring to finally obtain the whitening and freckle-removing composition.
6. The method for preparing a whitening and freckle removing composition according to claim 5, wherein in S1, the stirring rate is 1000 rpm; in S2, the stirring speed is 2000 rpm; in S3, the stirring speed is 200 rpm; in S4, the stirring rate was 150 rpm.
7. Use of a whitening and freckle-removing composition according to any one of claims 1 to 3 or obtained by a preparation method according to any one of claims 4 to 6 in the cosmetic field.
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