CN114748389B - Essence liquid and preparation method thereof - Google Patents
Essence liquid and preparation method thereof Download PDFInfo
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- CN114748389B CN114748389B CN202210464500.5A CN202210464500A CN114748389B CN 114748389 B CN114748389 B CN 114748389B CN 202210464500 A CN202210464500 A CN 202210464500A CN 114748389 B CN114748389 B CN 114748389B
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- CN
- China
- Prior art keywords
- skin
- water
- essence
- phyllanthus emblica
- solution
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- 239000007788 liquid Substances 0.000 title claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 68
- 235000015489 Emblica officinalis Nutrition 0.000 claims abstract description 59
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 32
- 239000000284 extract Substances 0.000 claims abstract description 32
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 20
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 20
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 20
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229940101267 panthenol Drugs 0.000 claims abstract description 20
- 239000011619 pantothenol Substances 0.000 claims abstract description 20
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- 240000009120 Phyllanthus emblica Species 0.000 claims abstract 5
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- IZMJMCDDWKSTTK-UHFFFAOYSA-N quinoline yellow Chemical compound C1=CC=CC2=NC(C3C(C4=CC=CC=C4C3=O)=O)=CC=C21 IZMJMCDDWKSTTK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention relates to essence water which adopts water as a main solvent and comprises nicotinamide, phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract, panthenol, butanediol and 1, 2-hexanediol. The invention also relates to a preparation method of the essence water.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to essence water and a preparation method thereof.
Background
Melanin is a major factor responsible for darkening skin tone and color spots. Melanin of skin is generally considered to be synthesized by catalysis of the amino acid-containing channel ammonase on melanosomes in melanocytes, and the process of oxidizing the amino acid into melanin is relatively complex, and under the influence of factors such as ultraviolet rays, living pressure, skin aging and the like, the activity of the amino acid-containing channel ammonase and the activity of the melanocytes can be enhanced, so that the oxidation can be promoted, the synthesis and deposition speed of the melanin can be accelerated, the pigmentation of the original pigment can be further deepened, and the skin darkening and the formation of color spots can be caused.
Skin dryness is another common skin problem. Since skin is the first line of defense of the body against harmful elements, dry skin can lead not only to an aesthetically unpleasant skin appearance, but also to itching, redness, spotting, irritation and inflammation. It is necessary and necessary to protect the skin from these factors and to treat dryness to avoid certain skin conditions.
Current cosmetic products on the market either do not effectively treat darkening and/or drying of the skin or have a irritating effect on the skin.
Definition of terms
The terms "about" or "approximately" are defined as being in close proximity as understood by one of ordinary skill in the art. In one non-limiting embodiment, the term is defined as within 10%, preferably within 5%, more preferably within 1%, most preferably within 0.5%.
The term "inhibit" or "reduce" or any variant of these terms includes any measurable reduction or complete inhibition in order to achieve the desired result.
The term "effective" means suitable for achieving a desired, expected or intended result.
The terms "comprising," "having," "including," or "containing" are inclusive or open-ended and do not exclude additional, unrecited elements or method steps.
The term "precipitation" refers to a phenomenon in which components or ingredients of the essence water appear in the form of solids (e.g., solid precipitates, needle-like crystals, blurred cotton-like substances, etc.). Visual precipitation may be possible. Alternatively, precipitation to such an extent that it is difficult to detect visually and transparency of the solution may be detected by a turbidity meter or an ultraviolet-visible infrared spectrophotometer. For example, the aqueous concentrate solution provided by the present invention is preferably colorless and transparent, but may precipitate over time due to a low-temperature storage test. Precipitation inhibition also includes preventing such precipitation, retarding, and reducing such precipitation.
Disclosure of Invention
Aiming at the technical problems in the prior art, the invention provides the essence water capable of effectively improving darkening and dryness of skin, which adopts water as a main solvent and has weak irritation to skin. The effective components of the essence water for improving skin darkening are nicotinamide and phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract. The essence adopts polyalcohol as a humectant, and the inventor discovers that: in aqueous solvent systems, particularly in the case of polyols as humectants in combination with nicotinamide and phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extracts, precipitation of the individual components does not occur during storage at low temperatures (ambient temperature about-2 ℃ to 4 ℃).
The inventors have conducted intensive studies to solve the above problems, and as a result, found that: since precipitation of the combination of the polyol and nicotinamide and the extract of the phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit due to low-temperature storage can be suppressed by limiting the polyol to the combination of panthenol, butanediol and 1, 2-hexanediol, precipitation during low-temperature storage can be suppressed even in the composition comprising the polyol and nicotinamide and the extract of the phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit.
The essence water provided by the invention acts on the skin through a combination of ingredients, and is used for revitalizing and restoring the skin matrix through attacking and/or up-regulating various biochemical pathways. These pathways include inhibiting the activity of matrix metalloproteinases in the skin, inhibiting the production of cyclooxygenase-1 and/or tyrosinase, inhibiting melanogenesis in the skin, and/or promoting the synthesis of collagen and/or lysyl oxidase in the skin. In some aspects, the essence provided herein can be effective to reduce skin conditions including photodamage, loss of facial firmness, fine lines, deep lines, wrinkles, skin dullness, skin dryness, age spots, or combinations thereof.
The essence water provided by the invention comprises nicotinamide, phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract, panthenol, butanediol and 1, 2-hexanediol. Wherein, the butanediol and the 1, 2-hexanediol have good moisturizing, anti-aging and repairing effects; the nicotinamide can reduce melanin which is generated and precipitated, obstruct the transfer of the melanin to surface cells, accelerate the metabolism of cells, accelerate the falling of melanocyte, maintain the water content of skin, promote the microcirculation of dermis, greatly reduce or eliminate the aging phenomenon of skin, reduce the damage of free radicals to the skin, and play roles in preventing aging, repairing the skin and reducing facial darkness; fructus Phyllanthi (PHYLLANTHUS EMBLICA) fruit extract with effects of whitening skin, reducing pigmentation, and inhibiting Fe 2+ /H 2 O 2 Formation, inhibition of peroxidase/H 2 O 2 Generation, inhibition of tyrosinase generation, inhibition of the activity of tyrosine, blocking of the synthesis of dopa and dopaquinone, and thus inhibition of melanin generation; panthenol has effects of brightening skin, keeping moisture, resisting oxidation, and delaying skin aging. Meanwhile, the addition amount range of nicotinamide, phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract, panthenol, butanediol and 1, 2-hexanediol is strictly controlled, and the synergistic effect is exerted to the greatest extent on the premise of reducing the irritation to skin, so that the whitening and moisturizing performances of the combination are improved.
In order to further reduce the skin irritation of the essence provided by the invention, the range of the addition amount of the polyalcohol in the essence needs to be reduced as far as possible under the condition of ensuring that the storage stability and the efficacy of the essence are not reduced, and the inventor discovers that: the combination of trehalose and sodium pyrrolidone carboxylate can be added as a humectant to essence water to reduce the amount of polyol added.
The invention provides essence water which takes water as a main solvent and comprises nicotinamide, phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract, panthenol, butanediol and 1, 2-hexanediol. More specifically, the essence water comprises:
0.01-0.1wt% disodium ethylenediamine tetraacetate (EDTA-2 Na);
0.2-1.2wt% sodium chloride;
0.2-8wt% trehalose;
0.1-5wt% sodium pyrrolidone carboxylate (PCA-Na);
0.02-1wt% citric acid;
sodium citrate 0.02-1 wt%;
0.1-8wt% panthenol;
0.5-5wt% nicotinamide;
0.2-3wt% of extract of Phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit;
0.5-10wt% butanediol;
0.2-1wt% of p-hydroxyacetophenone;
0.2-2wt% of 1, 2-hexanediol;
the balance being water.
The essence water provided by the invention comprises the following components: disodium edetate is used as a chelating agent; sodium chloride is a skin conditioner; p-hydroxyacetophenone is an antioxidant; the combination of citric acid and sodium citrate is used to adjust the pH of the serum to 4-8, preferably the pH of the serum is 5-6.
In some embodiments, the serum comprises an effective amount of an extract of phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit to inhibit matrix metalloproteinase activity. In some embodiments, the serum comprises an effective amount of niacinamide and phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract to stimulate collagen production in the skin. In some embodiments, the serum comprises an effective amount of an extract of phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit to inhibit tyrosinase in the skin. In some embodiments, the serum comprises an effective amount of phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract to inhibit cyclooxygenase-1 in the skin. In some embodiments, the serum comprises an effective amount of phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract to stimulate lysyl oxidase activity in the skin. In some embodiments, the serum comprises an effective amount of niacinamide to inhibit melanogenesis in the skin.
In the present invention, the extract of phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit may be an aqueous extract of phyllanthus emblica fruit. Aqueous extract refers to an aqueous solution that can be used as an extractant or solvent to obtain an extract. In the present invention, the extract of phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit is obtained using a combination of panthenol, butanediol and 1, 2-hexanediol and water as an extractant, and in some cases, the extractant contains 70 to 90 wt% of water.
In some aspects, by the essence water provided by the present invention, the skin can be treated to improve skin conditions including skin shine, skin tone permeability, skin brightness, skin tone uniformity, or a combination thereof. In some aspects, by applying the serum provided herein, the skin can be treated to reduce skin conditions including photodamage to the skin, loss of facial firmness, fine lines, deep lines, wrinkles, skin dullness, skin sagging, age-spots appearance, or a combination thereof. In some aspects, the skin may be treated to increase its moisture content. In some aspects, the skin moisture content can be increased within about 15 minutes of applying the essence provided by the present invention. In some aspects, skin may be treated to stimulate the production of matrix proteins, including collagen and/or lysyl oxidase, by applying the serum provided herein. In some aspects, skin is treated to inhibit cyclooxygenase-1 and/or tyrosinase production by application of the serum provided herein. In some aspects, skin may be treated to inhibit melanogenesis by applying the essence provided by the present invention. In some aspects, the essence provided herein may be applied to fine lines, wrinkles, age spots, or deep lines on the skin. In some aspects, the essence provided by the present invention can be applied to loose skin or inelastic skin. In some aspects, the essence provided by the invention can be applied to periorbital areas and/or fish tail areas of skin. In some aspects, the essence provided by the invention can be applied to facial skin or neck skin. In some aspects, the essence provided herein remains on the skin for at least 2 minutes. In some aspects, the essence provided herein may be administered once or more than once per day for at least 4 weeks.
It is contemplated that any of the embodiments discussed in this specification may be implemented for any of the methods or compositions of the invention, and vice versa. Furthermore, the compositions of the present invention may be used to carry out the methods of the present invention.
The invention also discloses a method for tightening and conditioning skin, which comprises the step of topically applying the essence water provided by the invention to skin in need thereof. "topical application" refers to the application or coating of a composition to the surface of the lips or keratinous tissue. The essence water provided by the present invention is dermatologically acceptable because it does not have abnormal toxicity, incompatibility, instability, allergic response, and the like when applied to skin and/or keratinous tissue. The essence provided by the present invention may have a viscosity selected to avoid significant dripping or pooling after application to the skin and/or keratinous tissue. "keratinous tissue" includes the keratinous-containing layers configured as the outermost protective layers of mammals, and includes, but is not limited to, lips, skin, and nails.
The invention also discloses a preparation method of the essence water, which comprises the following steps:
fully crushing phyllanthus emblica fruits by using a mixer to obtain crushed materials;
standing the crushed material in an extracting agent for at least 30 minutes at room temperature to obtain a mixture, wherein the extracting agent is a combination of panthenol, butanediol, 1, 2-hexanediol and water, and each 1kg of crushed material corresponds to 3L of extracting agent;
step three, centrifugally separating the mixture at the temperature of 2 ℃ and 20000xg for at least 20 minutes, collecting a liquid fraction, adding nicotinamide and disodium ethylenediamine tetraacetate into the liquid fraction, and uniformly mixing and stirring to obtain a first solution;
adding trehalose and sodium pyrrolidone carboxylate dissolved in water in advance into the first solution, and uniformly mixing and stirring to obtain a second solution;
step four, adding p-hydroxyacetophenone into the second solution, and uniformly mixing and stirring to obtain a third solution;
and fifthly, adding sodium chloride, citric acid and sodium citrate into the third solution, mixing and stirring uniformly, and supplementing the rest water to obtain the essence water.
In the process of preparing the essence, the viscosity of the essence is regulated by controlling the addition amount of sodium chloride, and the pH of the essence is regulated by controlling the addition amount of citric acid and sodium citrate.
Other objects, features and advantages of the present invention will become apparent from the following detailed description. However, it should be understood that the detailed description and examples, while indicating specific embodiments of the invention, are given by way of illustration only. In addition, it is contemplated that variations and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description.
Detailed Description
It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
As described above, the present invention provides a solution to the problems associated with darkening and dryness of the skin. The solution is premised on a combination of nicotinamide, phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract, panthenol, butanediol, and 1, 2-hexanediol.
The extract of fructus Phyllanthi (PHYLLANTHUS EMBLICA) fruit may be water extract of fructus Phyllanthi fruit. Fructus Phyllanthi, also known as black currant, is a fruit of the family Euphorbiaceae, lathyris. The extract of fructus Phyllanthi (PHYLLANTHUS EMBLICA) contains vitamin C (ascorbic acid). In some aspects, the phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract can be a source of flavonoids, apigenin, gallic acid, ellagic acid, quercetin, vitamin C, amino acids, copper, zinc, and chromium. Examples of extraction methods and processes for the extract of phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit disclosed in the prior art include the use of liquid-liquid extraction, solid phase extraction, water extraction, ethyl acetate, alcohols, acetone, oils, supercritical carbon dioxide, heat, pressure drop extraction, ultrasonic extraction, etc., the extract may be prepared as a liquid, a solid, a dry liquid, a re-suspended solid, etc. In the invention, the combination of panthenol, butanediol and 1, 2-hexanediol and water is used as an extracting agent to obtain the phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract, and the combination of panthenol, butanediol and 1, 2-hexanediol is simultaneously used as a humectant in essence water, so that the preparation method of the essence water disclosed by the invention has the advantage that the extraction of the phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract and the preparation of the essence water are simplified in process.
In the essence water provided by the invention, the combination of panthenol, butanediol, 1, 2-hexanediol and water can be taken as a carrier, and the essence water is a pharmaceutically or dermatologically acceptable carrier or carrier. So that the components of the serum are chemically compatible and do not form complexes that precipitate out of the final product.
Further research on the essence water provided by the invention shows that the composition can contain the following additional components in addition to the components of the essence water disclosed by the inventor under the premise of not affecting the storage stability and the use effect of the essence water, wherein the additional components are recorded in CTFA International cosmetic ingredient dictionary and handbook:
1. fragrances (artificial and natural, such as gluconic acid, phenoxyethanol, and triethanolamine);
2. dyes and coloring components (e.g., blue 1 lake, red 40, titanium dioxide, D & C blue No. 4, D & C green No. 5, D & C orange No. 4, D & C red No. 17, D & C red No. 33, D & C violet No. 2, D & C yellow No. 10, and D & C yellow No. 11);
3. vitamins (e.g., A, B, C, D, E and K);
4. essential oils, including oils from herbs, flowers, trees, and other plants. Such oils are typically present as tiny droplets between plant cells and may be extracted by several methods known to those skilled in the art (e.g., steam distillation, floral extraction, maceration, solvent extraction, or mechanical pressing).
5. Thickening agents, including substances that can increase the viscosity of the concentrate. Thickeners include those that can increase the viscosity of the composition without substantially altering the efficacy of the active ingredients within the composition. The thickener can also increase the stability of the essence water. Thickeners include hydrogenated polyisobutene, trihydroxystearin, ammonium acryloyldimethyl taurate/VP copolymer, carboxylic acid polymer, crosslinked polyacrylate polymer, polyacrylamide polymer, polysaccharide, or mixtures thereof.
The container for containing the essence water according to the present invention is preferably a nebulizer, a bottle, a tube, a dropper, or a dispenser, and examples of the material of the container include polyethylene terephthalate, polypropylene, polyethylene, ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, and metal. These materials may be used as container materials by various coating treatments in consideration of strength, flexibility, weather resistance, stability of components, and the like, or by combining or laminating these materials by mixing or the like, for example. Among them, polypropylene, polyethylene, ethylene vinyl alcohol resin, and metal are preferably used.
The essence water provided by the invention can expect whitening, drying resistance, aging resistance and low irritation effects, and can be used in known or conventional usage and dosage from 1 time per day to multiple times depending on the application and the like. According to the essence water provided by the invention, precipitation inhibition of the essence water in the low-temperature storage process can be realized through nicotinamide, phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract, panthenol, butanediol and 1, 2-hexanediol. It has been determined that the essence provided by the present invention can reduce skin dryness and improve skin firmness, skin elasticity, skin tone permeability, skin luster and/or brightness, skin tone uniformity and/or overall skin appearance.
The specific composition parameters of the essence water provided in examples 1-3 are shown in Table 1. The essence water provided in examples 1 to 3 was excellent in feeling of use.
The specific component parameters of the essence water provided in comparative examples 1 to 5 are shown in Table 2.
The essential oils provided in examples 1 to 3 and comparative examples 1 to 5 were prepared by using the preparation method disclosed in the present invention.
TABLE 1
TABLE 2
The essential oils provided in examples 1 to 3 and comparative examples 1 to 5 were tested as follows:
[ Low-temperature preservation test ]
The essence water provided in examples 1 to 3 and the essence water provided in comparative examples 1 to 5 were filled with 20mL of each sample in 20mL glass bottles, respectively. For these essence water samples, the samples were left to stand and stand in an incubator at-2℃for 1 week, and the presence or absence of precipitation of crystals was visually confirmed.
The result shows that:
1. the essence water provided in examples 1-3 does not precipitate, and the combination of nicotinamide, phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract, panthenol, butanediol and 1, 2-hexanediol enables the precipitation of the essence water to be inhibited in the low-temperature storage process, so that the essence water has stability;
2. the essence water provided in comparative examples 1 to 5 was precipitated, but the time of the precipitation of the essence water provided in comparative example 3 was the latest, the time of the precipitation of the essence water provided in comparative example 1 was the most, and the absence of any one component of the combination of nicotinamide, phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract, panthenol, butanediol and 1, 2-hexanediol caused the disappearance of the precipitation inhibition effect of the essence water during low temperature storage.
[ use test ]
Test sample: the essential oils provided in examples 1 to 3 and the essential oils provided in comparative examples 1 to 5 were used;
test population: 80 females with the age range of 25-40 years without skin allergy history and healthy skin;
the testing method comprises the following steps: the testers were randomly divided into 8 groups of 10 persons each, and each group was cleaned with the essence water provided in examples 1 to 3 and the essence water provided in comparative examples 1 to 5, respectively, and 3.0.+ -. 0.5g of the corresponding essence water sample was applied to the face before each use, and the application was uniform, and each time was carried out in the morning and evening, and the use was continued for 8 weeks. If the discomfort symptoms such as itch, burning, redness and the like of the skin occur for more than 2 times continuously in the middle, the use of the corresponding sample is stopped, and the test of the corresponding sample is finished.
And (3) observing the comparison of the front skin and the rear skin of the sample used by the subject, grading the whitening and moisturizing test results, carrying out statistics average division on the same group in 10 minutes, wherein the higher the grading is, the better the effect is. Meanwhile, sensitization (irritation including uncomfortable symptoms such as itching, burning, redness and the like) and skin feel and moisturizing effect are evaluated according to experience of a subject, wherein the moisturizing effect is prepared by scoring. The test results are shown in table 3 below.
TABLE 3 Table 3
| Sample of | Whitening effect | Moisturizing effect | Irritation (irritation) | Skin feel |
| Example 1 | 9.8 | 9 | No stimulation | Mild, non-sticky and easy to be absorbed |
| Example 2 | 9.2 | 8.5 | No stimulation | Mild, non-sticky and easy to be absorbed |
| Example 3 | 9.5 | 8.8 | No stimulation | Mild, non-sticky and easy to be absorbed |
| Comparative example 1 | 6.4 | 3.5 | No stimulation | Mild, non-sticky and slow-absorbing |
| Comparative example 2 | 3.1 | 5.4 | No stimulation | Mild, non-sticky and slow in absorption |
| Comparative example 3 | 2.4 | 6.2 | No stimulation | Mild, non-sticky and slow in absorption |
| Comparative example 4 | 6.1 | 4.5 | No stimulation | Mild, non-sticky and slow-absorbing |
| Comparative example 5 | 6.2 | 4.2 | No stimulation | Mild, non-sticky and slow-absorbing |
As can be seen from the results of the tests of examples 1 to 3 and comparative examples 2 to 3 in table 3, the absence of nicotinamide in the essence provided in comparative example 2 and the absence of phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit extract in the essence provided in comparative example 3 all resulted in reduced moisturizing and whitening properties of the essence and significantly reduced absorption rate of skin into the essence.
As is apparent from the examination results of examples 1 to 3 and comparative examples 1 and 4 to 5 in combination with table 3, the absence of any one of the combination of panthenol, butanediol and 1, 2-hexanediol in the serum leads to a decrease in the moisturizing and whitening properties of the serum, and the absorption rate of the skin into the serum is reduced, and it is presumed that the absence of any one of the combination of panthenol, butanediol and 1, 2-hexanediol decreases the stability of the serum and the activity of the active ingredients.
As can be seen from the results of the tests of examples 1-5 and comparative example 4 in tables 1-2, the addition amount of nicotinamide, alpha-arbutin and licorice root extract is reduced in comparative example 4, so that the moisturizing and whitening properties of the product are reduced, the addition amount of phyllanthus emblica extract is increased, the toxicological effect of the final product on skin is obvious, a slight redness phenomenon occurs, the cold resistance of the product is obviously reduced, and the stability is reduced.
The test results of examples 1-3 in Table 3 show that the essence provided by the invention is mild in water and not sticky, has no stimulation and toxicity to skin, and has obvious effect, so that the symptom of slight itching of skin appears; in addition, the cold resistance of the final product is significantly reduced and the stability is reduced.
All of the compositions and/or methods disclosed and claimed herein can be made and executed in accordance with the present disclosure without undue experimentation. While the compositions and methods of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations may be applied to the compositions and/or methods and in the steps or in the sequence of steps of the methods described herein without departing from the concept, spirit and scope of the invention. More specifically, it will be apparent that certain agents which are both chemically and physiologically related may be substituted for the agents described herein while the same or similar results would be achieved. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (1)
1. The preparation method of the essence water adopts water as a main solvent and is characterized in that,
the essence water comprises the following components:
0.01-0.1wt% disodium ethylenediamine tetraacetate (EDTA-2 Na);
0.2-1.2wt% sodium chloride;
0.2-8wt% trehalose;
0.1-5wt% sodium pyrrolidone carboxylate (PCA-Na);
0.02-1wt% citric acid;
sodium citrate 0.02-1 wt%;
0.1-8wt% panthenol;
0.5-5wt% nicotinamide;
0.2-3wt% of extract of Phyllanthus emblica (PHYLLANTHUS EMBLICA) fruit;
0.5-10wt% butanediol;
0.2-1wt% of p-hydroxyacetophenone;
0.2-2wt% of 1, 2-hexanediol;
the balance being water;
the preparation method comprises the following steps:
fully crushing phyllanthus emblica fruits by using a mixer to obtain crushed materials;
standing the crushed material in an extracting agent for at least 30 minutes at room temperature to obtain a mixture, wherein the extracting agent is a combination of panthenol, butanediol, 1, 2-hexanediol and water, and each 1kg of crushed material corresponds to 3L of extracting agent;
step three, centrifugally separating the mixture at the temperature of 2 ℃ and 20000xg for at least 20 minutes, collecting a liquid fraction, adding nicotinamide and disodium ethylenediamine tetraacetate into the liquid fraction, and uniformly mixing and stirring to obtain a first solution;
adding trehalose and sodium pyrrolidone carboxylate dissolved in water in advance into the first solution, and uniformly mixing and stirring to obtain a second solution;
step four, adding p-hydroxyacetophenone into the second solution, and uniformly mixing and stirring to obtain a third solution;
and fifthly, adding sodium chloride, citric acid and sodium citrate into the third solution, mixing and stirring uniformly, and supplementing the rest water to obtain the essence water.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176395A (en) * | 2016-08-09 | 2016-12-07 | 郑州景鸿畜牧科技有限公司 | Fructus Phyllanthi cleawhite over-night essences |
| CN112237560A (en) * | 2020-10-28 | 2021-01-19 | 广州品赫化妆品有限公司 | Whitening composition containing emblic leafflower fruits and application thereof |
| CN113456575A (en) * | 2021-08-11 | 2021-10-01 | 东晟源研究院(广州)有限公司 | Multi-effect pore astringent formula and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176395A (en) * | 2016-08-09 | 2016-12-07 | 郑州景鸿畜牧科技有限公司 | Fructus Phyllanthi cleawhite over-night essences |
| CN112237560A (en) * | 2020-10-28 | 2021-01-19 | 广州品赫化妆品有限公司 | Whitening composition containing emblic leafflower fruits and application thereof |
| CN113456575A (en) * | 2021-08-11 | 2021-10-01 | 东晟源研究院(广州)有限公司 | Multi-effect pore astringent formula and preparation method thereof |
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