CN114748389A - Essence water and preparation method thereof - Google Patents
Essence water and preparation method thereof Download PDFInfo
- Publication number
- CN114748389A CN114748389A CN202210464500.5A CN202210464500A CN114748389A CN 114748389 A CN114748389 A CN 114748389A CN 202210464500 A CN202210464500 A CN 202210464500A CN 114748389 A CN114748389 A CN 114748389A
- Authority
- CN
- China
- Prior art keywords
- skin
- water
- essence
- extract
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000002360 preparation method Methods 0.000 title abstract description 7
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- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 21
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 21
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- IZMJMCDDWKSTTK-UHFFFAOYSA-N quinoline yellow Chemical compound C1=CC=CC2=NC(C3C(C4=CC=CC=C4C3=O)=O)=CC=C21 IZMJMCDDWKSTTK-UHFFFAOYSA-N 0.000 description 1
- 235000012752 quinoline yellow Nutrition 0.000 description 1
- FZUOVNMHEAPVBW-UHFFFAOYSA-L quinoline yellow ws Chemical compound [Na+].[Na+].O=C1C2=CC=CC=C2C(=O)C1C1=NC2=C(S([O-])(=O)=O)C=C(S(=O)(=O)[O-])C=C2C=C1 FZUOVNMHEAPVBW-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention relates to essence water which adopts water as a main solvent and comprises niacinamide, an extract of emblic leafflower fruit (Phyllanthus EMBLICA) fruit, panthenol, butanediol and 1, 2-hexanediol. The invention also relates to a preparation method of the essence lotion.
Description
Technical Field
The invention relates to the field of cosmetics, and particularly relates to essence water and a preparation method thereof.
Background
Melanin is a major factor in darkening skin color and pigmentation. The melanin of skin is generally considered to be synthesized by the enzyme catalysis of the tyrosine aminotransferase on melanosomes in melanocytes, the process of the tyrosine aminotransferase for oxidizing the tyrosine into the melanin is relatively complicated, and the activity of the tyrosine aminotransferase and the activity of melanocytes can be enhanced under the influence of factors such as ultraviolet rays, living pressure, skin aging and the like, so that the oxidation is promoted, the synthesis and deposition speed of the melanin are accelerated, and the original pigmentation is deepened and even worsened, thereby leading to the darkening of skin and the formation of color spots.
Dry skin is another common skin problem. Since skin is the first line of defense of the body against harmful elements, dry skin may not only lead to an aesthetically displeasing appearance of the skin, but may also lead to itching, redness, blotchiness, irritation, and inflammation. It is necessary and necessary to protect the skin from these factors and to treat dryness to avoid certain skin conditions.
Current cosmetic products on the market either do not effectively treat skin darkening and/or skin dryness or are irritating to the skin.
Definition of terms
The term "about" or "approximately" is defined as being approximately as understood by one of ordinary skill in the art. In one non-limiting embodiment, the term is defined as within 10%, preferably within 5%, more preferably within 1%, and most preferably within 0.5%.
The terms "inhibit" or "reduce" or any variation of these terms includes any measurable reduction or complete inhibition to achieve a desired result.
The term "effective" means suitable to achieve a desired, expected, or intended result.
The terms "comprising," "having," "including," or "containing" are inclusive or open-ended and do not exclude additional, unrecited elements or method steps.
The term "precipitation" refers to the phenomenon in which the constituents or ingredients of the serum appear in the form of a solid (e.g., solid precipitates, needle crystals, hazy cotton-like substances, etc.). The precipitate may be visually precipitated. Alternatively, precipitation and transparency of the solution to such an extent that they are difficult to detect visually may be detected by a turbidimeter or an ultraviolet-visible-infrared spectrophotometer. For example, the essence aqueous solution provided by the present invention is preferably colorless and transparent, but may precipitate with time due to a low-temperature storage test. Precipitation inhibition also includes preventing, delaying and reducing such precipitation.
Disclosure of Invention
Aiming at the technical problems in the prior art, the invention provides the essence lotion capable of effectively improving skin darkening and skin dryness, wherein the essence lotion adopts water as a main solvent, and the essence lotion is weak in irritation to skin. The essential water contains effective components for improving skin darkening, such as nicotinamide and extract of fructus Phyllanthi (Phyllanthus EMBLICA) fruit. The essence water adopts polyhydric alcohol as a humectant, and the inventor finds that: in aqueous solvent systems, especially in the case of combining niacinamide and an extract of the fruit of Emblica officinalis (Phyllanthus EMBLICA) with a polyhydric alcohol as a humectant, precipitation of each component alone does not occur during storage at low temperatures (ambient temperature of about-2 ℃ to 4 ℃).
The inventors have made intensive studies to solve the above problems and as a result have found that: since precipitation due to low-temperature storage of the combination of polyhydric alcohol and nicotinamide and extract of the fruit of emblic leafflower fruit (PHYLLANTHUS EMBLICA) can be suppressed by limiting the polyhydric alcohol to the combination of panthenol, butylene glycol and 1, 2-hexanediol, the essence water provided by the present invention is suppressed in precipitation during low-temperature storage even in the case of the composition comprising polyhydric alcohol and nicotinamide and extract of the fruit of emblic leafflower fruit (PHYLLANTHUS EMBLICA).
The essential water provided by the invention acts on the skin through a combination of ingredients, which is used for revitalizing and restoring the skin matrix by attacking and/or up-regulating various biochemical pathways. These pathways include inhibiting the activity of matrix metalloproteinases in the skin, inhibiting the production of cyclooxygenase-1 and/or tyrosinase, inhibiting melanogenesis in the skin, and/or promoting the synthesis of collagen and/or lysyl oxidase in the skin. In some aspects, the essential oils provided herein are effective in reducing skin conditions including photodamage, loss of facial firmness, fine lines, deep lines, wrinkles, dull skin, dry skin, age spots, or combinations thereof.
The essence lotion provided by the invention comprises a combination of nicotinamide, emblic leafflower fruit (Phyllanthus EMBLICA) extract, panthenol, butanediol and 1, 2-hexanediol. Wherein, the butanediol and the 1, 2-hexanediol have good moisturizing, anti-aging and repairing effects; nicotinamide can reduce melanin formed and precipitated, prevent melanin from transferring to surface layer cells, and accelerate fine skin cell growthThe composition has the effects of promoting cell metabolism, accelerating the shedding of melanin keratinocytes, maintaining the moisture content of skin, promoting the microcirculation of the dermis, greatly reducing or eliminating the skin aging phenomenon, reducing the damage of free radicals to the skin, and playing the roles of preventing aging, repairing the skin and reducing the facial darkness; fructus Phyllanthi (Phyllanthus EMBLICA) extract with effects of whitening skin, reducing pigmentation, and inhibiting Fe2+/H2O2Production, inhibition of peroxidase/H2O2Generation, namely inhibiting the generation of tyrosinase, inhibiting the activity of tyrosine, and blocking the synthesis of dopa and dopaquinone, thereby inhibiting the generation of melanin; panthenol has effects of caring skin, keeping moisture, resisting oxidation, and delaying skin aging. At the same time, the addition ranges of the nicotinamide, the emblic leafflower fruit (Phyllanthus EMBLICA) extract, the panthenol, the butanediol and the 1, 2-hexanediol are strictly controlled, and the synergistic effect is exerted to the maximum extent on the premise of ensuring that the irritation to the skin is reduced, so that the whitening and moisturizing performances of the composition are improved.
In order to further reduce the irritation of the essence water provided by the invention to the skin, the addition amount range of the polyhydric alcohol in the essence water needs to be reduced as far as possible under the condition of ensuring that the storage stability and the efficacy of the essence water are not reduced, and the inventor finds that: the combination of trehalose and sodium pyrrolidone carboxylate can be added to the serum as a humectant to reduce the amount of added polyhydric alcohol.
The invention provides essence water which takes water as a main solvent and contains the combination of nicotinamide, emblic leafflower fruit (Phyllanthus EMBLICA) extract, panthenol, butanediol and 1, 2-hexanediol. More specifically, the essence comprises:
0.01-0.1 wt% disodium ethylenediaminetetraacetate (EDTA-2 Na);
0.2-1.2 wt% sodium chloride;
0.2-8 wt% trehalose;
0.1-5 wt% sodium pyrrolidone carboxylate (PCA-Na);
0.02-1 wt% citric acid;
0.02-1 wt% sodium citrate;
0.1-8 wt% panthenol;
0.5-5 wt% niacinamide;
0.2-3 wt% of extract of fruit of Emblica officinalis (Phyllanthus EMBLICA);
0.5 to 10 wt% of butanediol;
0.2-1 wt% of p-hydroxyacetophenone;
0.2 to 2 weight percent 1, 2-hexanediol;
the balance being water.
The invention provides the following essences: disodium ethylene diamine tetraacetate is taken as a chelating agent; sodium chloride is used as skin conditioner; p-hydroxyacetophenone as antioxidant; the combination of citric acid and sodium citrate is used to adjust the pH of the serum to 4-8, preferably, the pH of the serum to 5-6.
In some embodiments, the serum contains an effective amount of an extract of the fruit of EMBLICA officinalis (PHYLLANTHUS EMBLICA) to inhibit matrix metalloproteinase activity. In some embodiments, the serum contains effective amounts of niacinamide and an extract of the fruit of EMBLICA officinalis (PHYLLANTHUS EMBLICA) to stimulate collagen production in the skin. In some embodiments, the serum contains an effective amount of an extract of the fruit of EMBLICA officinalis (PHYLLANTHUS EMBLICA) to inhibit tyrosinase in the skin. In some embodiments, the serum contains an effective amount of an extract of the fruit of EMBLICA officinalis (PHYLLANTHUS EMBLICA) to inhibit cyclooxygenase-1 in the skin. In some embodiments, the serum contains an effective amount of an extract of the fruit of EMBLICA officinalis (PHYLLANTHUS EMBLICA) to stimulate lysyl oxidase activity in the skin. In some embodiments, the serum contains an effective amount of niacinamide to inhibit melanogenesis in the skin.
In the present invention, the extract of the fruit of Emblica officinalis (Phyllanthus EMBLICA) may be an aqueous extract of the fruit of Emblica officinalis. Aqueous extracts refer to aqueous solutions that can be used as an extractant or solvent to obtain an extract. It is noted that, in the present invention, an extract of emblic leafflower fruit (PHYLLANTHUS EMBLICA) is obtained using a combination of panthenol, butanediol, and 1, 2-hexanediol, and water as an extractant, and in some cases, the extractant contains 70 to 90% by weight of water.
In some aspects, the skin may be treated to improve skin conditions including skin radiance, skin tone clarity, skin brightness, skin tone uniformity, or combinations thereof, by the serum provided by the present invention. In some aspects, by applying the serum provided by the present invention, the skin can be treated to reduce skin conditions including photodamage of the skin, loss of facial firmness, fine lines, deep lines, wrinkles, skin dullness, skin laxity, age spots appearance, or combinations thereof. In some aspects, the skin may be treated to increase its moisture content. In some aspects, the moisture content of the skin can be increased within about 15 minutes of applying the serum provided by the present invention. In some aspects, the skin may be treated to stimulate production of matrix proteins, including collagen and/or lysyl oxidase, by applying the serum provided by the present invention. In some aspects, the skin is treated to inhibit the production of cyclooxygenase-1 and/or tyrosinase by applying the serum provided by the present invention. In some aspects, the skin can be treated to inhibit melanogenesis by applying the serum provided by the present invention. In some aspects, the essential lotion provided by the present invention can be applied to fine lines, wrinkles, age spots, or deep lines on the skin. In some aspects, the serum provided by the present invention may be applied to loose skin or inelastic skin. In some aspects, the serum provided by the present invention may be applied to the periorbital region and/or the crow's feet region of the skin. In some aspects, the serum provided by the present invention may be applied to facial skin or neck skin. In some aspects, the serum provided by the present invention is retained on the skin for at least 2 minutes. In some aspects, the serum provided by the present invention may be applied once or more than once daily for at least 4 weeks.
It is contemplated that any embodiment discussed in this specification can be implemented for any method or composition of the invention and vice versa. Furthermore, the compositions of the present invention may be used to carry out the methods of the present invention.
The invention also discloses a method for firming and conditioning skin, which comprises the step of topically applying the essence water provided by the invention to the skin in need. "topically applying" refers to applying or coating a composition to the surface of the lips or keratinous tissue. The serum provided by the present invention is dermatologically acceptable because it does not have abnormal toxicity, incompatibility, instability, allergic response, and the like when applied to the skin and/or keratinous tissue. The serum provided by the present invention may have a viscosity selected to avoid significant dripping or pooling after application to the skin and/or keratinous tissue. "keratinous tissue" includes keratinous-containing layers configured to be the outermost protective layer of a mammal, and includes, but is not limited to, lips, skin, and nails.
The invention also discloses a preparation method of the essence water, which comprises the following steps:
fully crushing phyllanthus emblica fruits by using a mixer to obtain crushed materials;
step two, standing the crushed material in an extracting agent at room temperature for not less than 30 minutes to extract to obtain a mixture, wherein the extracting agent is a combination of panthenol, butanediol, 1, 2-hexanediol and water, and each 1kg of the crushed material corresponds to 3L of the extracting agent;
step three, performing centrifugal separation on the mixture at 2 ℃ and 20000xg for not less than 20 minutes, collecting a liquid fraction, adding nicotinamide and disodium edetate into the liquid fraction, and mixing and stirring uniformly to obtain a first solution;
adding trehalose and sodium pyrrolidone carboxylate dissolved in water in advance into the first solution, and mixing and stirring uniformly to obtain a second solution;
adding p-hydroxyacetophenone into the second solution, and mixing and stirring uniformly to obtain a third solution;
and step five, adding sodium chloride, citric acid and sodium citrate into the third solution, mixing and stirring uniformly, and supplementing the rest water to obtain the essence water.
In the process of preparing the essence water, the viscosity of the essence water is adjusted by controlling the addition amount of sodium chloride, and the pH of the essence water is adjusted by controlling the addition amounts of citric acid and sodium citrate.
Other objects, features and advantages of the present invention will become apparent from the following detailed description. It should be understood, however, that the detailed description and the examples, while indicating specific embodiments of the invention, are given by way of illustration only. In addition, it is contemplated that variations and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description.
Detailed Description
It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
As mentioned above, the present invention provides a solution to the problems associated with skin darkening and skin dryness. The solution is premised on a combination of niacinamide, an extract of the fruit of Phyllanthus EMBLICA (Phyllanthus EMBLICA), panthenol, butanediol, and 1, 2-hexanediol.
The extract of fructus Phyllanthi (Phyllanthus EMBLICA) can be water extract of fructus Phyllanthi. Emblic leafflower fruit, also known as currant of indian origin, is the fruit of the deciduous tree of the family Euphorbiaceae (Euphorbiaceae). The extract of fruit of Phyllanthus EMBLICA (Phyllanthus EMBLICA) contains vitamin C (ascorbic acid). In some aspects, the extract of the fruit of EMBLICA officinalis (PHYLLANTHUS EMBLICA) may be a source of flavonoids, apigenin, gallic acid, ellagic acid, quercetin, vitamin C, amino acids, copper, zinc, and chromium. The extraction method and examples of the extract of the fruit of emblic leafflower (PHYLLANTHUS EMBLICA) disclosed in the prior art include using liquid-liquid extraction, solid phase extraction, water extraction, ethyl acetate, alcohol, acetone, oil, supercritical carbon dioxide, heat, pressure drop extraction, ultrasonic extraction, etc., and the extract can be prepared as liquid, solid, dried liquid, re-suspended solid, etc. In the present invention, the extract of the fruit of emblic leafflower fruit (PHYLLANTHUS EMBLICA) is obtained using a combination of panthenol, butylene glycol, and 1, 2-hexanediol as an extractant, and the combination of panthenol, butylene glycol, and 1, 2-hexanediol is simultaneously a humectant in the essence water, so that the extraction of the extract of the fruit of emblic leafflower fruit (PHYLLANTHUS EMBLICA) and the preparation of the essence water in the method for preparing the essence water disclosed in the present invention are simplified in process.
The combination of panthenol, butylene glycol, and 1, 2-hexanediol and water in the serum provided by the present invention can be considered a carrier, which is a pharmaceutically or dermatologically acceptable carrier or vehicle. So that the components of the serum are chemically compatible and do not form a complex that precipitates out of the final product.
Further research on the essence water provided by the invention finds that the composition can contain the following additional components besides the components of the essence water of the components disclosed by the inventor, which are recorded in the CTFA international cosmetic ingredient dictionary and handbook, on the premise of not influencing the storage stability and the use effect of the essence water:
1. fragrances (artificial and natural, such as gluconic acid, phenoxyethanol and triethanolamine);
2. dyes and coloring ingredients (e.g., blue 1 lake, red 40, titanium dioxide, D & C blue No. 4, D & C green No. 5, D & C orange No. 4, D & C red No. 17, D & C red No. 33, D & C violet No. 2, D & C yellow No. 10, and D & C yellow No. 11);
3. vitamins (e.g., A, B, C, D, E and K);
4. essential oils, including oils from herbs, flowers, trees, and other plants. Such oils typically exist as tiny droplets between plant cells and can be extracted by several methods known to those skilled in the art (e.g., steam distillation, floral extraction, maceration, solvent extraction, or mechanical pressing).
5. Thickeners, including substances that increase the viscosity of the serum. Thickeners include those that can increase the viscosity of the composition without substantially altering the efficacy of the active ingredients within the composition. Thickeners may also increase the stability of the serum. The thickener comprises hydrogenated polyisobutene, trihydroxystearin, ammonium acryloyldimethyl taurate/VP copolymer, carboxylic acid polymer, cross-linked polyacrylate polymer, polyacrylamide polymer, polysaccharide, or a mixture thereof.
The container for containing the essence liquid according to the present invention is preferably a sprayer, a bottle type, a tube type, a dropper type or a dispenser type, and the material of the container may be polyethylene terephthalate, polypropylene, polyethylene, ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, metal, or the like. These materials may be subjected to various coating treatments in consideration of strength, flexibility, weather resistance, stability of components, and the like, or may be combined or laminated by, for example, mixing, and used as a container material. Among them, polypropylene, polyethylene, ethylene vinyl alcohol resin, and metal are preferably used.
The essence lotion provided by the invention can expect the effects of whitening, anti-drying, anti-aging and low irritation, and can be used according to the application and the like from 1 time per day to a plurality of times, and the essence lotion can be used by a known or conventional use method and use amount. The essential water provided by the invention can realize the precipitation inhibition of the essential water in the low-temperature storage process through the nicotinamide, the emblic leafflower fruit (Phyllanthus EMBLICA) extract, the panthenol, the butanediol and the 1, 2-hexanediol. It has been determined that the serum provided by the present invention reduces skin dryness and improves skin firmness, skin elasticity, skin tone clarity, skin radiance and/or brightness, skin tone uniformity, and/or overall skin appearance.
The specific composition parameters of the serum provided in examples 1-3 are shown in table 1. The essential water provided in examples 1 to 3 had excellent feeling in use.
The specific composition parameters of the serum provided in comparative examples 1 to 5 are shown in table 2.
The essence liquids provided in examples 1 to 3 and the essence liquids provided in comparative examples 1 to 5 were prepared by the preparation methods disclosed in the present invention.
TABLE 1
TABLE 2
The serum provided in examples 1 to 3 and the serum provided in comparative examples 1 to 5 were subjected to the following tests:
[ Low temperature storage test ]
The essence solutions provided in examples 1 to 3 and comparative examples 1 to 5 were filled in 20mL glass bottles with 20mL of each sample, respectively. These serum samples were stored in an incubator at-2 ℃ for 1 week, and the presence or absence of crystal deposition was visually confirmed.
As a result, it was found that:
1. the essential water provided in examples 1 to 3 does not precipitate, and the combination of niacinamide, an extract of emblic leafflower fruit (PHYLLANTHUS EMBLICA), panthenol, butanediol, and 1, 2-hexanediol inhibits the precipitation of the essential water during low-temperature storage, and is more stable;
2. the serum provided in comparative examples 1 to 5 was precipitated, but the serum provided in comparative example 3 was precipitated at the latest, the serum provided in comparative example 1 was precipitated at the latest, and the absence of any one component of the combination of niacinamide, emblic leafflower fruit (PHYLLANTHUS EMBLICA) fruit extract, panthenol, butylene glycol, and 1, 2-hexanediol caused the precipitation-inhibiting effect of the serum to disappear during low-temperature storage.
[ test for use ]
Test samples: the essence water provided by the examples 1-3 and the essence water provided by the comparative examples 1-5;
testing the population: 80 women, age range 25-40 years, no history of skin allergy, healthy skin;
the test method comprises the following steps: the testers were randomly divided into 8 groups of 10 persons each, and the essence solutions provided in examples 1 to 3 and comparative examples 1 to 5 were used, respectively, and both hands were washed before each use, and 3.0 ± 0.5g of the corresponding essence solution sample was applied to the face, evenly applied, once in the morning and once in the evening, and continuously used for 8 weeks. And if uncomfortable symptoms such as pruritus, burning, redness and the like continuously appear for more than 2 times in the midway, stopping using the corresponding sample, and finishing the test of the corresponding sample.
And observing the comparison of the skin of a subject before and after using the sample, performing a score system on the test results of whitening and moisturizing, wherein the score system is 10 points in full, the same group is subjected to statistical average score, and the higher the score is, the better the effect is. Meanwhile, according to the experience of the subject, the sensitization (irritation, including uncomfortable symptoms such as pruritus, scorching, redness and the like), the skin feeling and the moisturizing effect are evaluated, wherein the moisturizing effect is prepared by a grading method. The test results are shown in table 3 below.
TABLE 3
| Sample (I) | Whitening effect | Moisturizing effect | Irritation property | Skin feel |
| Example 1 | 9.8 | 9 | Has no irritation | Mild, non-sticky, and easy absorption |
| Example 2 | 9.2 | 8.5 | Has no irritation | Mild, non-sticky, and easy absorption |
| Example 3 | 9.5 | 8.8 | Has no irritation | Mild, non-sticky, and easy absorption |
| Comparative example 1 | 6.4 | 3.5 | Has no irritation | Mild, non-sticky, and slow absorption |
| Comparative example 2 | 3.1 | 5.4 | Has no irritation | Mild, non-sticky, and slow absorption |
| Comparative example 3 | 2.4 | 6.2 | Has no irritation | Mild, non-sticky, and slow absorption |
| Comparative example 4 | 6.1 | 4.5 | Has no irritation | Mild, non-sticky, and slow absorption |
| Comparative example 5 | 6.2 | 4.2 | Has no irritation | Mild, non-sticky, and slow absorption |
Combining the test results of examples 1-3 and comparative examples 2-3 in table 3, it can be seen that the absence of niacinamide in the serum provided in comparative example 2 and the absence of an extract of emblic leafflower fruit (PHYLLANTHUS EMBLICA) in the serum provided in comparative example 3 both result in a reduction in the moisturizing and whitening performance of the serum and significantly reduce the rate of absorption of the serum by the skin.
Combining the test results of examples 1-3 and comparative examples 1 and 4-5 in table 3, it is known that the absence of any component of the combination of panthenol, butylene glycol and 1, 2-hexanediol in the serum causes the reduction of the moisturizing and whitening performance of the serum, and reduces the absorption rate of the serum to the skin, and it is hypothesized that the absence of any component of the combination of panthenol, butylene glycol and 1, 2-hexanediol reduces the stability of the serum and the activity of the effective components.
According to the detection results of the examples 1-5 and the comparative example 4 in the tables 1-2, the addition amount of the nicotinamide, the alpha-arbutin and the licorice root extract is reduced in the comparative example 4, so that the moisturizing and whitening performance of the product is reduced, the addition amount of the emblic leafflower fruit extract is increased, the toxicological effect of the final product on skin is obvious, a slight reddening phenomenon occurs, the cold resistance of the product is remarkably reduced, and the stability is reduced.
According to the detection results of the examples 1-3 in the table 3, the essence provided by the invention is water-warm and non-sticky, has no irritation to the skin and has obvious toxicological effect, so that the skin is slightly itchy; in addition, the cold resistance of the final product is significantly reduced and the stability is reduced.
All of the compositions and/or methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure. While the compositions and methods of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations may be applied to the compositions and/or methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention. More specifically, it will be apparent that certain agents which are both chemically and physiologically related may be substituted for the agents described herein while the same or similar results would be achieved. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (3)
1. An essence lotion, which uses water as a main solvent, and is characterized in that the essence lotion comprises a combination of niacinamide, an extract of the fruit of Emblica officinalis (Phyllanthus EMBLICA), panthenol, butylene glycol and 1, 2-hexanediol.
2. The essence water according to claim 1, wherein the essence water comprises:
0.01-0.1 wt% disodium ethylenediaminetetraacetate (EDTA-2 Na);
0.2-1.2 wt% sodium chloride;
0.2-8 wt% trehalose;
0.1-5 wt% sodium pyrrolidone carboxylate (PCA-Na);
0.02-1 wt% citric acid;
0.02-1 wt% sodium citrate;
0.1-8 wt% panthenol;
0.5-5 wt% niacinamide;
0.2-3 wt% of extract of fruit of Emblica officinalis (Phyllanthus EMBLICA);
0.5 to 10 wt% of butanediol;
0.2-1 wt% of p-hydroxyacetophenone;
0.2 to 2 weight percent 1, 2-hexanediol;
the balance being water.
3. Method for preparing the serum according to claim 1 or 2, characterized in that it comprises the following steps:
fully crushing phyllanthus emblica fruits by using a mixer to obtain crushed materials;
step two, standing the crushed material in an extracting agent for not less than 30 minutes at room temperature to extract to obtain a mixture, wherein the extracting agent is a combination of panthenol, butanediol, 1, 2-hexanediol and water, and each 1kg of the crushed material corresponds to 3L of the extracting agent;
step three, performing centrifugal separation on the mixture at 2 ℃ and 20000xg for not less than 20 minutes, collecting liquid fractions, adding nicotinamide and disodium edetate into the liquid fractions, and mixing and stirring uniformly to obtain a first solution;
adding trehalose and sodium pyrrolidone carboxylate dissolved by water in advance into the first solution, and mixing and stirring uniformly to obtain a second solution;
adding p-hydroxyacetophenone into the second solution, and mixing and stirring uniformly to obtain a third solution;
and step five, adding sodium chloride, citric acid and sodium citrate into the third solution, mixing and stirring uniformly, and supplementing the rest water to obtain the essence water.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176395A (en) * | 2016-08-09 | 2016-12-07 | 郑州景鸿畜牧科技有限公司 | Fructus Phyllanthi cleawhite over-night essences |
| CN112237560A (en) * | 2020-10-28 | 2021-01-19 | 广州品赫化妆品有限公司 | Whitening composition containing emblic leafflower fruits and application thereof |
| CN113456575A (en) * | 2021-08-11 | 2021-10-01 | 东晟源研究院(广州)有限公司 | Multi-effect pore astringent formula and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176395A (en) * | 2016-08-09 | 2016-12-07 | 郑州景鸿畜牧科技有限公司 | Fructus Phyllanthi cleawhite over-night essences |
| CN112237560A (en) * | 2020-10-28 | 2021-01-19 | 广州品赫化妆品有限公司 | Whitening composition containing emblic leafflower fruits and application thereof |
| CN113456575A (en) * | 2021-08-11 | 2021-10-01 | 东晟源研究院(广州)有限公司 | Multi-effect pore astringent formula and preparation method thereof |
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