CN107496245B - Anti-aging liposome composition and preparation method and application thereof - Google Patents
Anti-aging liposome composition and preparation method and application thereof Download PDFInfo
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- CN107496245B CN107496245B CN201710832467.6A CN201710832467A CN107496245B CN 107496245 B CN107496245 B CN 107496245B CN 201710832467 A CN201710832467 A CN 201710832467A CN 107496245 B CN107496245 B CN 107496245B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention relates to the field of daily chemicals, and discloses an anti-aging liposome composition which comprises the following components in percentage by weight: 5-10% grapefruit peel oil; 0.1-5% of northern african cedar bark oil: 0.2-1% quinoa seed extract; 20-50% sucrose laurate; 9-15% 1, 3-propanediol; 0.1-0.5% of sodium ascorbyl phosphate; 3-5% of soybean lecithin; the deionized water is added to make up to 100 percent. The composition effectively improves the hydration ability of the skin, enhances the barrier function of the skin and improves the elasticity of the skin through the synergistic effect of the components, thereby effectively delaying the skin aging, and the unique liposome coating technology increases the absorption of active substances, reduces the addition of active substances, and reduces the product, side effect and cost.
Description
Technical Field
The invention relates to the field of daily chemicals, in particular to an anti-aging liposome composition and a preparation method thereof, and relates to cosmetics containing the composition.
Background
The skin is aged to form wrinkles, so that the original plump and glossy skin becomes uneven, the skin refractivity becomes poor, and the original glossy skin loses the original luster. The water content of the aged skin is reduced, the pigment is correspondingly increased, and pigmentation such as chloasma and senile plaque is generated. The appearance of clinical symptoms such as wrinkles and age spots has complex psychological and physiological influences on people's life and work after the aging phenomenon occurs, and can cause a series of psychological problems such as anxiety, depression, self-mutism and the like. Anti-aging product cosmetics have been on the market, and people hope to improve and improve the quality of life by anti-aging.
Aging is one of the most basic natural laws in the biological world, and skin aging is classified into extrinsic aging and extrinsic aging, and the extrinsic aging is mainly caused by environmental factors such as ultraviolet radiation, smoking, wind blowing, sunlight and contact with harmful chemical substances. Ultraviolet radiation in sunlight is a major factor in extrinsic aging. The skin is also prone to aging under prolonged environmental erosion. Aged skin is rough and slightly hypertrophic, deep furrows, ridges and leather-like appearance, i.e., so-called deep wrinkles, such as a rhomboidal skin. Prolonged sun exposure can cause thickening of the skin cuticle, or a disturbance in the barrier function of the cuticle. Changes in the skin microcirculation can also occur, such as telangiectasia or disappearance, a dull, dull or yellowish appearance of the skin.
The aging mechanism is very complex, and the representative aging theory mainly comprises the theory of cell mutation, the theory of DNA damage, the theory of mitochondrial damage, the theory of telomeres, the theory of free radicals, the theory of nonenzymatic glycosylation, the theory of immune function change and the theory of neuroendocrine aging. The theory of cell mutation is that the number of cell divisions is proportional to the lifespan, and aging is caused by cell damage and mutation, so that the cells themselves and the cells after division are abnormal, physiological functions are reduced, and the number of divisions is reduced. The theory of free radicals is that under normal conditions, the generation and elimination of free radicals in the body are in dynamic equilibrium, and once the equilibrium is broken, excessive free radicals are generated, and toxic attack on biological tissues such as chromosomes, mitochondria, cell membranes and connective tissues can cause aging of the body.
The reduction of epidermal barrier function is closely related to skin dryness. The water content in the stratum corneum is 10-15%, the relative constancy of water depends on natural moisturizing factors: amino acids, pyrrolidone carboxylic acid, lactate, urea, uric acid, creatine, phosphate, etc., decrease in the content of natural moisturizing factors in the stratum corneum with age, resulting in a decrease in the hydration capacity of the skin, which is only 75% of normal skin. If the barrier function of the stratum corneum is damaged, the loss of water in the skin is accelerated, and the aging of the skin is also accelerated. The stable barrier function of the stratum corneum of the skin is the key to keeping the skin healthy, and when the barrier function of the stratum corneum is stable, the skin can show a good healthy state, so that the skin aging is delayed.
Currently, the main anti-aging products on the market are mainly aimed at three aspects: 1. scavenging free radicals from the skin; 2. supplementing water and protein components lost from the skin from the outside by adding some moisturizers or nutrients; 3. promoting cell metabolism. The percutaneous absorption routes of cosmetics are the stratum corneum, hair follicles and sweat glands, but the latter two routes only account for less than 1% of the entire skin surface, but most nutrients are difficult to pass through the lipid-rich stratum corneum. Most products in the market hope to achieve the product effect by adding a large amount of nutrient substances or humectants, but the nutrient substances are often not completely absorbed and utilized by the skin, the bioavailability is low, the cost is high, and meanwhile, the expected effect of the product cannot be achieved.
The liposome has unique hydrophilic and lipophilic structure, can soften cutin, make the encapsulated substance reach the action position, and can form a layer of protective film on the surface of skin to moisten and moisten skin. Chinese patent CN 106539711 a discloses a novel skin lotion and a preparation method thereof, wherein moisturizers such as seabuckthorn oil liposome, glycerin, hyaluronic acid and the like provide moisturizing and anti-aging effects, but the anti-aging effect is provided only by seabuckthorn oil, and the effect is not significant. Chinese patent CN 104490677 a discloses a liposome essence emulsion, which is a liposome composed of bioactive components such as cell growth factors, etc., and humectants such as saussurea involucrate extract, hyaluronic acid, glycerol, etc., and has high bioavailability, excellent effect, but high cost.
Disclosure of Invention
The invention aims to solve the technical problem of providing an anti-aging liposome composition and a preparation method thereof, wherein the composition effectively improves the hydration capability of skin, enhances the barrier function of the skin and improves the elasticity of the skin through the synergistic effect of the components, thereby effectively delaying skin aging, and the composition has a unique liposome coating technology, increases the absorption of active substances, reduces the addition amount of the active substances, and reduces the product, side effects and cost.
The technical problem to be solved by the invention is realized by the following technical scheme:
an anti-aging liposome composition comprises the following components in percentage by weight:
5-10% grapefruit peel oil;
0.1-5% of northern african cedar bark oil:
0.2-1% quinoa seed extract;
20-50% sucrose laurate;
9-15% 1, 3-propanediol;
0.1-0.5% of sodium ascorbyl phosphate;
3-5% of soybean lecithin;
the deionized water is added to make up to 100 percent.
Further, the following components in percentage by weight are preferred:
6-8% of grapefruit peel oil.
0.5-3.5% of North African cedar bark oil.
0.2-0.8% quinoa seed extract;
further, the following components in percentage by weight are preferred: 25-35% sucrose laurate.
Further, the following components in percentage by weight are preferred: 7.5-13.5% of 1, 3-propanediol.
Further, the following components in percentage by weight are preferred: 0.35-0.45% of sodium ascorbyl phosphate.
Further, the following components in percentage by weight are preferred: 2.5-4.5% of soybean lecithin.
The preparation method of the grapefruit peel oil comprises the following steps:
a. drying grape oil pericarp, mashing, and sieving with 50-200 mesh sieve;
b. b, immersing the grapefruit peel obtained in the step a in an ethanol solution, crushing in an ultrasonic cell crusher for 20-30min, and drying the obtained liquid by rotary evaporation to remove ethanol;
c. b, putting the grapefruit peel powder obtained in the step b into an extraction kettle for carbon dioxide supercritical extraction to obtain grapefruit peel oil, wherein the control parameters are as follows: the pressure is 20MPa-35MPa, the temperature is 25-60 ℃, the extraction time is 60-120min, and the flow of carbon dioxide is 10L/min-20L/min.
The preparation method of the anti-aging liposome composition comprises the following steps:
(1) dissolving sodium ascorbyl phosphate in a citrate buffer solution, wherein the concentration of the citrate buffer solution is 0.08mol/L, and the amount of the citrate buffer solution is adjusted to be 6-7.5 of the pH value of a solution system to obtain an aqueous phase solution;
(2) mixing grapefruit peel oil, Cedar tree peel oil, quinoa seed extract and sucrose laurate, heating and stirring at 50-65 deg.C at 80-200rpm for 30min to obtain oil phase solution;
(3) mixing soybean lecithin and 1, 3-propylene glycol according to the ratio of 1: 3, uniformly mixing, and supplementing the balance of water;
(4) under the condition of stirring, adding the water phase solution and the oil phase solution into the soybean lecithin and 1, 3-propylene glycol solution while homogenizing, homogenizing at 30-60 ℃ for 10-20min, carrying out ultrasonic treatment for 5-10 min, and filtering with a microporous filter membrane to obtain a liposome finished product.
A leave-on or rinse-off cosmetic composition comprising the anti-aging liposome composition in any ratio.
Further, the cosmetic is in the form of cream, milky lotion, water, gel
After the technical scheme is applied, the invention has the following beneficial effects:
1. the active ingredients of the anti-aging liposome composition provided by the invention comprise grapefruit peel oil, quinoa seed extract, cedar bark oil and sodium ascorbyl phosphate. The grapefruit peel oil has wide biological activity, contains rich flavonoids, has various pharmacological effects in human bodies and animal bodies, can generate flavone free radicals by combining hydrogen atoms on phenolic hydroxyl groups of the grapefruit peel oil with peroxy radicals, and further reacts with other free radicals to stop free radical chain reaction, and the flavonoids have excellent capabilities of clearing free radicals, resisting allergy, viruses and inflammation, reducing capillary fragility and the like, can deeply purify pimples, fill and compact skin and the like, can enhance the capacity of cells for resisting the free radicals, and further improve the skin barrier function. The content of the flavonoids in the grapefruit peel oil can be effectively improved by extracting the grapefruit peel oil with supercritical carbon dioxide.
2. The high-quality quinoa seed contains 16-22% of protein, is rich in various amino acids, wherein all 9 essential amino acids necessary for human bodies are contained, particularly the quinoa seed is rich in lysine, calcium, magnesium, phosphorus, potassium, iron, zinc, selenium, manganese, copper and other mineral substances which are deficient in plants, has high nutrient content, is rich in unsaturated fatty acid, flavonoid, B vitamins, E vitamins, choline, betaine, folic acid, α -linolenic acid, β -glucan and other beneficial compounds, and the quinoa seed extract contains various small molecular substances, can be effectively absorbed through skin, permeates into a dermis layer, provides deep and strong moisturizing capability, improves skin hydration capability, enhances fibroblast activity, promotes collagen secretion and enables cells to be rich in elasticity.
3. Cedar is a generic term of tree species of cedar genus of Pinaceae family, has various pharmacological activities of spasmolysis, analgesia, anti-inflammation, anticancer, antibacterial, antivirus and the like in medicine, and cedar bark oil contains abundant procyanidine which is a bioflavonoid with a special molecular structure, is a natural antioxidant which is internationally recognized at present and is most effective in removing free radicals in human body, and has obvious free radical resistance, UV resistance and oxidation resistance.
4. The sodium ascorbyl phosphate has strong reducibility, can reduce melanin intermediates, reduce formed melanin, reduce black specks and freckles, activate the collagen synthesis process, interfere the formation of lipid peroxide, effectively improve skin aging, enable the skin to be compact and elastic, improve skin lines and reduce damaged skin lines. In addition, in the present invention, ascorbic acid also has a stabilizing effect, an effect of enhancing the liposome membrane strength, and an effect of improving the stability of the active substance.
5. The liposome prepared by the invention has a structure similar to that of skin, can soften cutin, enables the encapsulated active substance to permeate into the cutin and reach an action part, and can form a layer of breathable protective film on the surface of the skin, reduce the water loss of the skin and enhance the barrier function of the skin.
6. Compared with the prior art, the anti-aging liposome composition prepared by the invention has multiple effects of improving skin lines, improving skin elasticity, improving skin hydration capacity, reducing water loss, enhancing skin barrier function and the like through mutual coordination and mutual promotion among various active substances. The prepared liposome can improve skin penetration of effective components, increase bioavailability of active substances in skin, reduce additive amount of active substances, and reduce product and cost.
Detailed Description
The present invention will be described in detail with reference to examples, which are only preferred embodiments of the present invention and are not intended to limit the present invention.
Example 1
An anti-aging liposome composition comprises the following components in percentage by weight:
8% of grapefruit peel oil, 1% of Cedar pine bark oil, 0.3% of quinoa seed extract, 35% of sucrose laurate, 12% of 1, 3-propylene glycol, 0.3% of sodium ascorbyl phosphate, 4% of soybean lecithin and the balance of deionized water to 100%.
Wherein the grapefruit peel oil is prepared in the following manner:
(1) drying grape oil pericarp, mashing, and sieving with 50-200 mesh sieve;
(2) immersing the grapefruit peel obtained in the step (1) in an ethanol solution, crushing in an ultrasonic cell crusher for 20-30min, and evaporating the obtained liquid in a rotary evaporation mode to remove ethanol.
(3) Putting the grapefruit peel powder obtained in the step (2) into an extraction kettle, wherein the parameters are as follows: the pressure is 33MPa, the temperature is controlled to be 25-40 ℃, the extraction time is 80-90min, and the flow of carbon dioxide is controlled to be 15-18L/min.
The preparation method of the anti-aging liposome composition comprises the following steps:
(1) dissolving sodium ascorbyl phosphate in a citrate buffer solution, wherein the concentration of the citrate buffer solution is 0.08mol/L, and the amount of the citrate buffer solution is adjusted to ensure that the pH value of a solution system is adjusted to 6.8 to obtain an aqueous phase solution;
(2) mixing grapefruit peel oil, Cedar pine bark oil, quinoa seed extract and sucrose laurate, heating and stirring at 50-65 ℃, stirring at the speed of 130-150rpm, and stirring for 30min to obtain an oil phase solution;
(3) mixing soybean lecithin and 1, 3-propylene glycol according to the ratio of 1: 3, uniformly mixing, and supplementing the balance of water;
(4) under the condition of stirring, adding the water phase solution and the oil phase solution into the soybean lecithin and 1, 3-propylene glycol solution while homogenizing, homogenizing at 30-60 ℃ for 10-20min, carrying out ultrasonic treatment for 5-10 min, and filtering with a microporous filter membrane to obtain the liposome.
Comparative example 1
An anti-aging liposome composition comprises the following components in percentage by weight:
8% of virgin grapefruit peel oil, 1% of northwest cedar bark oil, 0.3% of quinoa seed extract, 35% of sucrose laurate, 12% of 1, 3-propylene glycol, 0.3% of sodium ascorbyl phosphate, 4% of soybean lecithin, and deionized water to make up to 100%. Wherein the grapefruit peel oil is prepared by a cold pressing method.
The preparation method of the anti-aging liposome composition comprises the following steps:
(1) dissolving sodium ascorbyl phosphate in a citrate buffer solution, wherein the concentration of the citrate buffer solution is 0.08mol/L, and the amount of the citrate buffer solution is adjusted to be 6, so as to obtain an aqueous phase solution;
(2) mixing grapefruit peel oil, Cedar pine bark oil, quinoa seed extract and sucrose laurate, heating and stirring at 50-65 ℃, stirring at the speed of 130-150rpm, and stirring for 30min to obtain an oil phase solution;
(3) mixing soybean lecithin and 1, 3-propylene glycol according to the ratio of 1: 3, uniformly mixing, and supplementing the balance of water;
(4) under the condition of stirring, adding the water phase solution and the oil phase solution into the soybean lecithin and 1, 3-propylene glycol solution while homogenizing, homogenizing at 30-60 ℃ for 10-20min, carrying out ultrasonic treatment for 5-10 min, and filtering with a microporous filter membrane to obtain the liposome.
Comparative example 2
An anti-aging liposome composition comprises the following components in percentage by weight:
8% of grapefruit peel, 0.3% of quinoa seed extract, 35% of sucrose laurate, 12% of 1, 3-propylene glycol, 0.3% of sodium ascorbyl phosphate, 4% of soybean lecithin and deionized water to make up to 100%.
The preparation method of the anti-aging liposome composition comprises the following steps:
(1) dissolving sodium ascorbyl phosphate in a citrate buffer solution, wherein the concentration of the citrate buffer solution is 0.08mol/L, and the amount of the citrate buffer solution is adjusted to ensure that the pH value of a solution system is adjusted to 7 to obtain an aqueous phase solution;
(2) mixing grapefruit peel oil, Cedar pine bark oil, quinoa seed extract and sucrose laurate, heating and stirring at 50-65 ℃, stirring at the speed of 130-150rpm, and stirring for 30min to obtain an oil phase solution;
(3) mixing soybean lecithin and 1, 3-propylene glycol according to the ratio of 1: 3, uniformly mixing, and supplementing the balance of water;
(4) under the condition of stirring, adding the water phase solution and the oil phase solution into the soybean lecithin and 1, 3-propylene glycol solution while homogenizing, homogenizing at 30-60 ℃ for 10-20min, carrying out ultrasonic treatment for 5-10 min, and filtering with a microporous filter membrane to obtain the liposome.
Comparative example 3
An anti-aging liposome composition comprises the following components in percentage by weight:
8% of grapefruit peel oil, 1% of Cedar pine bark oil, 0.3% of quinoa seed extract, 35% of sucrose laurate, 12% of 1, 3-propylene glycol, 4% of soybean lecithin, and deionized water to make up to 100%.
Wherein the grapefruit peel oil is prepared in the following manner:
(1) drying grape oil pericarp, mashing, and sieving with 50-200 mesh sieve;
(2) immersing the grapefruit peel obtained in the step (1) in an ethanol solution, crushing in an ultrasonic cell crusher for 20-30min, and evaporating the obtained liquid in a rotary evaporation mode to remove ethanol.
(3) Putting the grapefruit peel powder obtained in the step (2) into an extraction kettle, wherein the parameters are as follows: the pressure is 33MPa, the temperature is controlled to be 25-40 ℃, the extraction time is 80-90min, and the flow of carbon dioxide is controlled to be 15-18L/min.
The preparation method of the anti-aging liposome composition comprises the following steps:
(1) the water phase solution is citrate buffer solution, and the weight of the citrate buffer solution is 0.9 percent of the total weight of the formula;
(2) mixing grapefruit peel oil, Cedar pine bark oil, quinoa seed extract and sucrose laurate, heating and stirring at 50-65 ℃, stirring at the speed of 130-150rpm, and stirring for 30min to obtain an oil phase solution;
(3) mixing soybean lecithin and 1, 3-propylene glycol according to the ratio of 1: 3, uniformly mixing, and supplementing the balance of water;
(4) under the condition of stirring, adding the water phase solution and the oil phase solution into the soybean lecithin and 1, 3-propylene glycol solution while homogenizing, homogenizing at 30-60 ℃ for 10-20min, carrying out ultrasonic treatment for 5-10 min, and filtering with a microporous filter membrane to obtain the liposome.
Comparative example 4
An anti-aging liposome composition comprises the following components in percentage by weight:
8% of grapefruit peel oil, 1% of Beifei cedar bark oil, 0.3% of quinoa seed extract, 35% of sucrose laurate, 12% of glycerol, 0.3% of sodium ascorbyl phosphate and deionized water to complement to 100%, and the components are mixed, stirred and dissolved uniformly.
Wherein the grapefruit peel oil is prepared in the following manner:
(1) drying grape oil pericarp, mashing, and sieving with 50-200 mesh sieve;
(2) immersing the grapefruit peel obtained in the step (1) in an ethanol solution, crushing in an ultrasonic cell crusher for 20-30min, and evaporating the obtained liquid in a rotary evaporation mode to remove ethanol.
(3) Putting the grapefruit peel powder obtained in the step (2) into an extraction kettle, wherein the parameters are as follows: the pressure is 33MPa, the temperature is controlled to be 25-40 ℃, the extraction time is 80-90min, and the flow of carbon dioxide is controlled to be 15-18L/min.
The preparation method of the anti-aging liposome composition comprises the following steps:
(1) dissolving sodium ascorbyl phosphate by using a citrate buffer solution to form an aqueous phase solution, wherein the weight ratio of the citrate buffer solution to the sodium ascorbyl phosphate is 3: 1;
(2) mixing grapefruit peel oil, Cedar pine bark oil, quinoa seed extract and sucrose laurate, heating and stirring at 50-65 ℃, stirring at the speed of 130-150rpm, and stirring for 30min to obtain an oil phase solution;
(3) under the condition of stirring, adding the water phase solution and the oil phase solution into glycerol while homogenizing, and stirring uniformly to obtain the finished product.
Example 1 and comparative examples 1-4 above were each added to an emulsion base at an amount of 5% by weight of the emulsion base to prepare example 2 and comparative examples 5-8, respectively.
The skin elasticity, skin glossiness, moisture loss through the skin, and moisture content of the skin were measured for example 2 and comparative examples 5 to 8: 30 volunteers between 20-35 years of age were selected for each sample and tested to compare skin elasticity and skin gloss before and after use.
Table 1: efficacy evaluation test results of examples and comparative examples
| Item | 12 hours moisture content (%) | Average Water loss Rate (%) through epidermis at 12 hours | Skin elasticity increment (%) | Skin gloss increment (%) |
| Example 2 | 78.9 | 0.98 | 2.12 | 4.66 |
| Comparative example 5 | 55.5 | 1.65 | 1.25 | 1.52 |
| Comparative example 6 | 63.1 | 1.70 | 1.38 | 3.75 |
| Comparative example 7 | 67.8 | 1.27 | 1.45 | 2.02 |
| Comparative example 8 | 40.2 | 2.1 | 0.86 | 1.14 |
The grapefruit peel oil added in comparative example 5 is virgin grapefruit peel oil, and the glossiness and skin elasticity are significantly reduced compared with example 2; in comparative example 6, the moisture content of the skin and the elasticity of the skin are obviously reduced compared with example 2 without adding the Cedrus asiatica oil, and the average moisture loss rate through the epidermis is also obviously increased because the small molecular nutrient components in the skin can not be synergistically supplemented with other components; in comparative example 7, in which sodium ascorbyl phosphate was not added, skin elasticity and skin gloss were also significantly reduced, because melanin deposited on the skin for a long time could not be reduced and free radicals could not be removed in cooperation with other raw materials, and thus skin elasticity and gloss were less increased; in comparative example 8, since no liposome encapsulation technique was used, transdermal absorption of the active substance was reduced, and the liposome failed to form a moisturizing membrane on the skin surface, each index was significantly different from that of example 5.
Claims (7)
1. An anti-aging liposome composition is characterized by being prepared from the following components in percentage by weight:
5-10% grapefruit peel oil;
0.1-5% of northern african cedar bark oil:
0.2-1% quinoa seed extract;
20-50% sucrose laurate;
9-15% 1, 3-propanediol;
0.1-0.5% of sodium ascorbyl phosphate;
3-5% of soybean lecithin;
supplementing deionized water to 100%;
wherein the grapefruit peel oil is prepared in the following manner:
(1) drying grape oil pericarp, mashing, and sieving with 50-200 mesh sieve;
(2) immersing the grapefruit peel obtained in the step (1) in an ethanol solution, crushing in an ultrasonic cell crusher for 20-30min, and evaporating the obtained liquid to dryness to remove ethanol;
(3) putting the grapefruit peel powder obtained in the step (2) into an extraction kettle, wherein the parameters are as follows: the pressure is 33MPa, the temperature is controlled to be 25-40 ℃, the extraction time is 80-90min, and the flow of carbon dioxide is controlled to be 15-18L/min;
the preparation method of the anti-aging liposome composition comprises the following steps:
(1) dissolving sodium ascorbyl phosphate in a citrate buffer solution, wherein the concentration of the citrate buffer solution is 0.08mol/L, and the amount of the citrate buffer solution is adjusted to be 6-7.5 of the pH value of a solution system to obtain an aqueous phase solution;
(2) mixing grapefruit peel oil, Cedar tree peel oil, quinoa seed extract and sucrose laurate, heating and stirring at 50-65 deg.C at 80-200rpm for 30min to obtain oil phase solution;
(3) mixing soybean lecithin and 1, 3-propylene glycol according to the ratio of 1: 3, uniformly mixing, and supplementing the balance of water;
(4) under the condition of stirring, adding the water phase solution and the oil phase solution into the soybean lecithin and 1, 3-propylene glycol solution while homogenizing, homogenizing at 30-60 ℃ for 10-20min, carrying out ultrasonic treatment for 5-10 min, and filtering with a microporous filter membrane to obtain a liposome finished product.
2. The liposomal anti-aging composition according to claim 1, wherein the grapefruit peel oil is present in an amount of 6 to 8% by weight, the Cedar pine bark oil is present in an amount of 0.5 to 3.5% by weight, and the quinoa seed extract is present in an amount of 0.2 to 0.8% by weight.
3. The anti-aging liposome composition according to claim 1, wherein the sucrose laurate is 25-35% by weight.
4. The anti-aging liposome composition according to claim 1, wherein the 1, 3-propanediol is 12% by weight.
5. The anti-aging liposome composition according to claim 1, wherein the weight percentage of the sodium ascorbyl phosphate is 0.35-0.45%.
6. A leave-on or rinse-off cosmetic comprising the antiaging liposome composition of any one of claims 1-5.
7. The leave-on or rinse-off cosmetic as claimed in claim 6, wherein the cosmetic is in the form of any one of cream, milky, water, gel.
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|---|---|---|---|---|
| CN106616171A (en) * | 2016-09-18 | 2017-05-10 | 大连普瑞康生物技术有限公司 | Probiotic beverage containing saussurea involucrate culture and preparation method thereof |
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