CN112773740A

CN112773740A - Firming and wrinkle-removing essence and preparation method thereof

Info

Publication number: CN112773740A
Application number: CN201911091833.2A
Authority: CN
Inventors: 戎钟洪
Original assignee: Guangzhou Yingnaier Cosmetics Co ltd
Current assignee: Guangzhou Yingnaier Cosmetics Co ltd
Priority date: 2019-11-08
Filing date: 2019-11-08
Publication date: 2021-05-11

Abstract

The invention relates to the field of cosmetics, and particularly relates to wrinkle-removing essence and a preparation method thereof. The wrinkle-removing essence mainly comprises the following components: levorotatory vitamin C, oligopeptide-1, folium Ginkgo extract, folium Camelliae sinensis extract, hyaluronic acid, D-panthenol, and tea flower SOD. The levorotatory vitamin C in the wrinkle-removing essence is one of substances necessary for skin collagen synthesis, is also a strong reducing agent, and can resist oxidation. It can promote skin collagen synthesis, neutralize free radical in skin, and repair skin damage caused by ultraviolet ray. Can also participate in the reaction of melanin generation and reduce the intermediate oxidized by tyrosinase, thereby preventing the generation of melanin and achieving the effects of whitening and removing freckles; oligopeptide-1 can effectively inhibit cell degeneration, enhance immune function and reduce loss of collagen, thereby improving relaxation; the flavone component in folium Ginkgo extract can scavenge free radicals, reduce cell free radical injury, and delay skin aging.

Description

Firming and wrinkle-removing essence and preparation method thereof

Technical Field

The invention relates to the field of cosmetics, and particularly relates to a wrinkle-removing and firming essence and a preparation method thereof

Background

Wrinkles are the initial signs of skin aging, which are the lines of the skin surface that shrink to form a convexity and concavity. The reason for the formation of wrinkles is many, and mainly includes the following: 1. natural aging: the natural aging of human body leads to the slow synthesis of collagen and elastin in the dermis of the skin, and the fast decomposition of the collagen and elastin by protease leads to the reduction of the elasticity of the skin and the appearance of wrinkles. 2. Sun damage: when sunlight irradiates the skin, free radicals are generated, and the free radicals can destroy collagen in the skin, so that the skin is loosened, and wrinkles are generated. 3. Expression lines: wrinkles can be formed in any expression after the long-term accumulation, for example, habitual frown eyebrows are very easy to form glabellar wrinkles or glabellar lines, and the canthus crow's feet are easy to form crow's feet and the like when people frequently have a big smile.

For the above reasons, the commonly used wrinkle removing methods are: 1. acceleration of collagen synthesis and inhibition of metalloprotease activity in skin: the collagen decomposition rate in young skin is comparable to the regeneration rate, and skin maintains elasticity at all times. The rate of collagen production in aged skin is slowed, resulting in faster rates of breakdown than regeneration. Collagenase in the skin accelerates the breakdown of collagen in the dermis. Accelerating collagen synthesis in the skin or inhibiting collagenase activity in the skin can reduce the difference between the regeneration rate and the decomposition rate of collagen in the skin, thereby delaying the rate of wrinkles in the skin. 2. Scavenging free radicals: the use of substances with antioxidant activity can reduce the damage of free radicals to cells by removing or combining free radicals of human bodies, and prevent collagen from being damaged. 3. Paralysis of local muscles: oligopeptide, botulinum and other substances can inhibit the release of acetylcholine from cholinergic nerve endings, cause muscle relaxation type paralysis, and further achieve the effect of wrinkle removal. 4. Moisturizing and water replenishing: the skin is kept sufficient in moisture and the cells are full, so that the skin can be firmer and can better resist external stimulation and injury.

The invention takes high-concentration vitamin C as a main wrinkle-removing raw material, and the high-concentration vitamin C can better permeate into the dermis of the skin and participate in the synthesis reaction of collagen of the skin, thereby accelerating the regeneration of the collagen in the dermis of the skin, removing free radicals in the skin and relieving the damage of the collagen caused by the free radicals. The oligopeptide-1 is added for repairing the skin, and plant extracts rich in phenols and flavonoids such as tea extract and ginkgo leaf extract are used for enhancing the effects of vitamin C in the two aspects, so that the effects of removing wrinkles and tightening the skin are achieved.

Disclosure of Invention

The invention comprehensively considers various wrinkle-removing mechanisms, and one purpose of the invention is to provide the wrinkle-removing and firming essence which is prepared by compounding a tea extract, citric acid, trehalose, hyaluronic acid, tea flower SOD, oligopeptide-1, D-panthenol, a ginkgo leaf extract and vitamin C, and achieves the effects of removing wrinkles and firming by the synergistic effect of different wrinkle-removing mechanisms. The invention also aims to provide a preparation method of the wrinkle-removing and firming essence.

In order to achieve the first object, the invention adopts the following design scheme:

the wrinkle-removing and firming essence comprises the following components in percentage by mass:

the levorotatory vitamin C content is not less than 99.5%, the tea polyphenol content in the tea extract is not less than 98%, the hyaluronic acid is white powdery solid, the molecular weight of the hyaluronic acid is less than 1 kilodalton, the oligopeptide-1 is a tripeptide molecule, the sequence is GHK, the protein content is not less than 1.63mg/ml, the D-panthenol content is 100%, the SOD activity of the tea flower SOD is not less than 1512U/g, the ginkgo biloba leaf flavonol glycoside content in the ginkgo leaf extract is not less than 24%, the terpene ester content is not less than 6%, the trehalose content is not less than 99%, and the citric acid content is not less than 99%.

Preferably, the composition comprises the following components in percentage by mass:

preferably, the levovitamin C is white powder obtained by two-stage fermentation of glucose, and the content of the levovitamin C is more than 99%.

Preferably, the trehalose is white solid powder, is prepared from corn serving as a raw material by a fermentation enzymolysis secondary crystallization method, and has a content of more than 99%.

Preferably, the tea flower SOD is white paste, and the SOD activity of the tea flower SOD is not less than 1512U/g.

Preferably, the tea extract is a tan solid powder, wherein the tea polyphenol content is not less than 98%.

Preferably, the hyaluronic acid is a white powdery solid having a molecular weight of less than 1 ten thousand daltons.

Preferably, the oligopeptide-1 is a tripeptide molecule with the sequence GHK, wherein the content of protein is not less than 1.63 mg/ml.

Preferably, the ginkgo biloba extract is brown solid powder, wherein the content of ginkgo flavonol glycosides is not less than 24%, and the content of terpene lactones is not less than 6%.

Preferably, the citric acid is white crystalline powder prepared by fermentation, wherein the content of citric acid monohydrate is more than 99.5%.

The anti-wrinkle firming essence can also contain 0.35-0.5% of preservative.

In order to achieve the second object, the invention adopts the following technical scheme:

a method for preparing the wrinkle-removing and firming essence comprises the following steps:

1) adding deionized water, sodium hyaluronate and EDTA-2Na into a reaction kettle, stirring, heating to 75-80 ℃, and uniformly mixing.

2) Adding folium Ginkgo extract and folium Camelliae sinensis extract into mixed solution of butanediol and ethoxy diglycol, stirring at room temperature until dissolved to brown transparent liquid.

3) And (3) starting cooling circulating water, stirring and cooling, adding the mixture obtained in the second step into a reaction pot when the temperature is reduced to 45-50 ℃, adding tea flower SOD, D-panthenol, citric acid and trehalose, and stirring and dissolving completely.

4) Stirring and cooling to below 40 deg.C, adding tea flower SOD, oligopeptide-1 and levovitamin C, and dissolving completely.

5) And stopping stirring and finishing.

Vitamin C is one of the substances necessary for skin collagen synthesis, is also a strong reducing agent, and has antioxidant effect. It can promote skin collagen synthesis, neutralize free radical in skin, and repair skin damage caused by ultraviolet ray. In addition, the compound can also participate in the reaction of melanin generation, and reduce the intermediate oxidized by tyrosinase, thereby preventing the generation of melanin and playing the effects of whitening and removing freckles.

Oligopeptide-1 is a tripeptide molecule with the sequence GHK. Oligopeptide-1 has various positive effects on cells. It can effectively inhibit cell degeneration, enhance immune function, and reduce collagen loss, thereby improving relaxation.

D-panthenol is a precursor of vitamin B5, and the skin care effect is characterized by deeply penetrating moisturizers, stimulating the growth of epithelial cells and promoting wound healing.

The folium Ginkgo extract has effects of removing wrinkle and whitening skin. The flavone component contained in the composition can remove free radicals in skin, thereby protecting collagen in skin from being damaged by the free radicals and delaying skin aging.

The tea extract is an excellent natural antioxidant, has synergistic effect with vitamin C, vitamin E, carotenoid, etc., and has improved antioxidant effect. Researches show that the effective components in the tea extract also have the effects of resisting tumors and aging and regulating blood fat.

The tea flower SOD has the important effects of regulating endocrine, improving immunity, detoxifying, inhibiting bacteria, reducing blood fat, reducing blood sugar, resisting cancer, resisting oxidation and the like, and has multiple oxidation resisting and caring effects on skin.

Drawings

FIG. 1 example of an image of a subject's eyes

FIG. 2 example of neck image of subject

Detailed Description

The wrinkle-removing and firming essence provided by the invention is prepared by taking levorotatory vitamin C, oligopeptide-1, tea flower SOD, D-panthenol, tea extract, ginkgo leaf extract, trehalose and citric acid as main components and adding humectant, thickener, preservative and water which are common matrix components of cosmetics. The present invention will be described below with reference to some specific examples, but the present invention is not limited thereto.

Example 1

Wrinkle-removing and firming essence:

the wrinkle-removing and firming essence comprises the following components in percentage by weight:

component (percentage)	Example 1	Example 2	Example 3	Example 4
					Levo-vitamin C	5	10	8	15
Trehalose	2	1	4	3
					Oligopeptide-1	0.5	0.2	0.2	0.4
D-panthenol	0.3	0.4	0.2	0.25
					Hyaluronic acid sodium salt	0.05	0.08	0.2	0.25
Tea flower SOD	0.05	0.15	0.2	0.3
					Ginkgo leaf extract	0.3	0.5	0.1	0.2
Tea leaf extract	0.9	0.1	0.5	0.7
					Citric acid	2	1.5	0.5	0.25
EDTA-2Na	0.05	0.05	0.05	0.05
					Butanediol	3	4	5	6
Ethoxy diglycol	10	25	10	25
					Preservative	0.35	0.35	0.35	0.35
Deionized water	Balance of	Balance of	Balance of	Balance of

The preparation method of the essence is provided. The method comprises the following steps:

1) adding deionized water, sodium hyaluronate and EDTA-2Na into a reaction kettle, stirring, heating to 80-85 ℃, and uniformly mixing.

4) Stirring and cooling to below 40 deg.C, adding oligopeptide-1, levovitamin C and antiseptic, and dissolving completely.

5) And stopping stirring and finishing.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent changes made by using the description of the present invention or directly and indirectly applied to other related technical fields are also included in the scope of the present invention.

Example 3 evaluation of Effect

Clinical experiments were carried out on the wrinkle-removing and firming essence provided in example 3

In order to verify the effects of the product on the aspects of wrinkle resistance and firmness, 90 volunteers are selected to carry out effectiveness experiments, a double-blind design and a comparison experiment are adopted to carry out comparison examination, the 90 volunteers are unlimited in male and female, healthy people are 30-50 years old, 30 people are divided into 3 groups at random, the experimental group 1 uses xx wrinkle-removing products, and the experimental groups 2-3 use the invention products. The essence is used once a day, morning and evening, the pump head bottle is pressed 1-2 times to uniformly spread the essence on two parts with wrinkles on eyes and neck, the essence is massaged until the essence is completely absorbed, each user is regularly tracked and investigated, a skin tester (Callegari Soft Plus Italy) is used for monitoring wrinkles, skin elasticity and skin moisture, the test is carried out once every 7 days, and the use lasts for 14 days. (during the test period, other wrinkle-removing and tightening efficacy products are stopped)

Information acquisition: the mean values of the skin parameters at the beginning of the experiment (D0), the mean value of the skin parameters at 7 days of the beginning of the experiment (D7), and the mean value of the skin parameters at 14 days of the experiment (D14) were recorded for each group of volunteers, respectively, and the difference between the mean values of the skin parameters for two time periods (D7-D0; D14-D7) was calculated. The skin improvement rate is the number of skin improvement people per total number of people in each group.

As can be seen from the table, after 2 weeks of the experiment, the elastic moisture of the tested part of the sample is uniformly and obviously improved, and the skin improvement rate reaches more than 70%; the test result of the control group is far worse than the effect of the product of the invention, and the skin improvement rate is only 20%.

From figure 1, the obvious fine lines and the eye corner lines on the eyes can be seen, and after the tightening and wrinkle-removing essence disclosed by the invention is used for 2 weeks, the fine lines are obviously faded and even completely disappear. And the skin state around the eyes is obviously improved and is in a healthy state.

(ii) a As can be seen from figure 2, the neck lines are obvious before use, and the folds are deep; after the tightening and wrinkle-removing essence is used for 2 weeks, the cervical wrinkles are faded, the wrinkles become shallow, and the problem of deep cervical wrinkles can be remarkably improved after the tightening and wrinkle-removing essence is used for a long time.

Evaluation criteria: the sense of use is through the volunteer's self-describing feelings; the skin texture condition is directly observed by naked eyes and tested by skin texture, wherein, the effect is as follows: the skin texture becomes fine and smooth obviously, the fine lines on the face are reduced obviously when the face is observed by naked eyes, and the deep lines become shallow; the general formula is as follows: the skin texture becomes slightly lighter, and wrinkles are reduced by visual observation compared with the wrinkles before the experiment, but the reduction is not obvious; and (4) invalidation: the skin texture was unchanged from that before the experiment.

After 14 days of use, the effective rate is over 50 percent by revisiting and recording the users, and all experimenters have no anaphylaxis or other toxic and side effects.

In conclusion, the firming and wrinkle-removing product has obvious wrinkle-removing effect, namely the product has double effects of firming skin and removing wrinkles.

Claims

1. The tightening and wrinkle-removing essence comprises the following components in percentage by mass:

2. the tightening and wrinkle-removing essence according to claim 1, characterized in that the content of levovitamin C is not less than 99.5%; the content of tea polyphenol in the tea extract is not lower than 98%; the hyaluronic acid is white powdery solid, and the molecular weight of the hyaluronic acid is less than 1 ten thousand daltons; oligopeptide-1 is tripeptide molecule with GHK sequence, wherein the content of protein is not less than 1.63 mg/ml; the content of D-panthenol is 100%; the tea flower SOD is white paste, and the SOD activity of the tea flower SOD is not less than 1512U/g; the ginkgo biloba extract contains ginkgo flavonol glycosides not less than 24% and terpene esters not less than 6%; the content of trehalose is not less than 99%, and the content of citric acid is not less than 99%.

3. The tightening and wrinkle-removing essence according to claim 1, characterized in that the composition comprises the following components in percentage by mass:

4. the tightening and wrinkle-removing essence according to claim 1, wherein the composition comprises the following components in percentage by mass:

5. the tightening and wrinkle-removing essence according to claim 1, 2 or 3, wherein the L-ascorbic acid is white powder obtained by two-stage fermentation of glucose, and the content of the L-ascorbic acid is more than 99%.

6. The tightening and wrinkle-removing essence according to claim 1, 2 or 3, wherein the tea extract is a tan solid powder having a tea polyphenol content of not less than 98%.

7. The tightening and wrinkle-removing essence according to claim 1, 2 or 3, wherein the hyaluronic acid is a white powdery solid having a molecular weight of less than 1 ten thousand daltons.

8. The tightening and wrinkle-removing essence according to claim 1, 2 or 3, wherein the oligopeptide-1 is a tripeptide molecule with the sequence of GHK, wherein the protein content is not less than 1.63 mg/ml.

9. The tightening and wrinkle-removing essence according to claim 1, 2 or 3, wherein the ginkgo biloba extract is brown solid powder, in which the ginkgo flavonol glycoside content is not less than 24% and the terpene lactone content is not less than 6%.

10. A method for preparing the tightening and wrinkle-removing essence according to any one of claims 1 to 9. The method is characterized by comprising the following steps:

3) And (3) starting cooling circulating water, stirring and cooling, adding the mixture obtained in the second step into a reaction kettle when the temperature is reduced to 45-50 ℃, adding the D-panthenol, the citric acid and the trehalose, and stirring and dissolving completely.

5) And stopping stirring and finishing.