KR20080026800A - Cosmetic composition - Google Patents

Abstract

A cosmetic composition is provided to induce no skin diseases due to non-stimulating property and being permeated into skin easily and safely, inhibit the melanogenesis significantly by inhibiting antioxidizing capacity and tyrosinase activity, thereby providing excellent whitening effect and improving durability of the effects. A cosmetic composition comprises 0.0001-00 wt.% of a fermented extract of a herb medicine obtained by adding the herb medicine to yeast or lactic acid bacteria and then culturing it, wherein the herb medicine is at least one selected from the group consisting of Angelica tenuissima, Phaseolus radiatus, Angelicae dahuricae, Gleditschia officinalis and Trichosanthes kirilowii, the yeast is at least one selected from the group consisting of Saccharomyces sp., Schizosaccharomyces sp., Torulopsis sp., Rhodotorula sp., and Candida, and the lactic acid bacteria is at least one selected from the group consisting of Lactobacillus sp., Streptococcus sp., Leuconostoc sp., and Bifidobacteria sp..

Description

Cosmetic composition {COSMETIC COMPOSITION}

The present invention relates to a cosmetic composition, more specifically, non-irritating, easy and safe penetration into the skin, there is no problem of causing skin diseases, inhibiting antioxidant activity, tyrosinase activity, and excellent ability to significantly inhibit melanin production The present invention relates to a cosmetic composition having improved whitening effect and persistence of the effect.

The human desire to have beautiful skin, that is, the desire to cultivate beauty and maintain youth, is human instinct since birth. To satisfy this, the term skin beauty was born and its history has long been established. In addition to beauty instincts, skin beauty has emphasized two concepts of protecting skin from the outside.

Looking at the history of skin beauty, skin care in the Gojoseon era resolved the craving for white skin using wormwood and garlic, as shown in Dangun mythology, and the townspeople in the cold regions of the northeastern Korean peninsula avoided the cold by using pig oil. It is said to protect the skin and prevent frostbite, and the Malgales are said to wash their face with urine to whiten the skin. Also, during the Goryeo Dynasty, the face was decorated with white powder. During the Joseon Dynasty, the face was made using cucumbers and honey, and especially in the "Union book", various hair types, ten ways of drawing eyebrows, and various lip sticks. How to shoot is recorded.

In Korea, the standard of value for beauty is placed on the concept of young and fleshly ideology, which emphasizes the beauty of inner beauty as well as external beauty. In particular, the skin is closely related to blood donation and meridians, and since it is directly connected to each blood donation of the five intestines, the skin is a mirror that can examine the state of the body and mind as it is. I saw that.

Recently, the use of medicinal herbs in the cosmetics field has been reported to be excellent in moisturizing, anti-aging, and antioxidant effects, especially in terms of skin wrinkle improvement effect, and there have been many studies on cosmetic compositions using herbal extracts.

However, the herbal compositions using the herbal extracts extracted by conventional methods have not only the desired effect of whitening, anti-wrinkle, anti-oxidation, etc., but also have a long time to obtain such extracts, and thus the practicality was not high.

On the other hand, the fermentation broth extract extracts the active ingredient content of flavonoids, vitamin C, vitamin P, amino acids, catechins, etc. contained in the herbal medicine through the fermentation and aging process by changing the sugar component of the herbal medicine into alcohol by not using any other solvent. This is significantly higher, thereby achieving a much more excellent whitening, anti-wrinkle effect.

Therefore, there is no need to develop a new cosmetic that has no irritation to the skin through the extract of the herbal medicine fermentation, the absorption from the skin is increased, the stability and the whitening effect is maximized in vivo.

In order to solve the problems of the prior art as described above, the present invention is non-irritating, easy and safe penetration into the skin, there is no problem of causing skin diseases and inhibits antioxidant activity, tyrosinase activity is excellent in the ability to significantly inhibit melanin production To provide a cosmetic composition that can improve the whitening effect and the persistence of the effect.

Another object of the present invention is to provide a cosmetic composition that is superior to the conventional whitening agent for skin absorption, has little cytotoxicity, allergy, skin irritation, human irritation, etc. and can be safely used as a whitening cosmetic having antibacterial activity.

In order to achieve the above object, the present invention provides a cosmetic composition comprising a herbal medicine fermented extract obtained by adding and culturing the herbal medicine to yeast or lactic acid bacteria as an active ingredient.

Hereinafter, the present invention will be described in detail.

The inventors of the present invention applying the herbal extract of the fermentation broth obtained by fermenting the herbal medicine to the cosmetic composition, the extraction rate of the active ingredient contained in the herbal medicine is significantly increased, according to the free radical scavenging function, antioxidant activity, whitening effect, human After confirming the safety to the skin, the present invention was completed.

Cosmetic composition of the present invention is characterized in that it comprises a herbal medicine fermented extract as an active ingredient.

The medicinal herb fermentation extract used in the present invention can be obtained by adding and culturing the medicinal herb to yeast or lactic acid bacteria.

The yeast is Saccharomyces sp ., Schizosaccharomyces sp ., Torulopsis sp ., Rhodotorula sp ., Or Candida sp . Microorganisms, such as these, can be used.

In addition, the lactic acid bacteria Lactobacillus sp ., Streptococcus sp ., Leuconostoc sp ., Or Bifidobacteria sp . Microorganisms, such as these, can be used.

The medicinal herb added to the yeast or lactic acid bacteria as described above may be used alone or in combination of two or more of the original, green beans, white paper, flakes, or cheonhwabun.

Preferably, the herbal, green beans, white paper, sculptural, and natural ingredients are all mixed by using the herbal medicines in a weight ratio of 1.0 to 4.0: 2.5 to 10.0: 1.0 to 4.0: 0.1 to 2.5: 0.1 to 2.5, respectively. . When mixed in such a compounding ratio, the effects of the respective herbal ingredients can be complemented with each other to further improve the effect.

The tomb used in the present invention (Angelica tenuissima) is a perennial herb of the perennial herb, dried root stems and roots in the nephronous herbaceous plant has a strong divergence action to relieve various pains, such as headache, modern pharmacologically anti-inflammatory It is known to have antipyretic, analgesic, soothing and antibacterial effects.

The mung bean (Phaseolus radiatus) to dry the green beans of the legumes to lower the heat in the synonym Bogam, detoxification, thirst removal effect, and modern pharmacologically effective in various skin diseases such as acne, blemishes, freckles It is known.

The white paper (Angelica dahurica) is dried roots of 2-3 year-old herbaceous plants belonging to the obstetric family, and the nephrogenic herbaceous acid has a strong divergence effect, which is effective for headaches and rhinitis, removes swelling and is effective for arthritis. Pharmacology is known to have analgesic, fever, smooth muscle relaxation, anti-inflammatory action.

The cheonhwahwa (Trichosanthes kirilowii) is a dried root of the skin of the perennial herbaceous herbaceous perennial herb, which is dried in the new agricultural plants, and is said to have the effect of removing thirst, removing swelling, etc. Immune regulation, anticancer, lowering blood sugar, antibacterial, etc. are known to work.

The sculptor (Gleditschiae sinensis) is dried thorns of the fruit belonging to the legumes, and the medicinal plywood has the effect of popping out the boiled tightly, removing the phlegm and lowering the edema, modern pharmacologically antibacterial, antifungal, etc. It is known to work.

The medicinal herbs are extracted in a powdered state or mixed with the above ratio, distilled water or solvent such as 1,3-butylene glycol, propylene glycol, ethanol, and so on to obtain 5 to 50% by weight of the medicinal herbs, and then cold or warmed for 3 days. It can then be used in the state of the extract prepared by the usual method of filtration with a 0.1-1 μm filter.

The medicinal herb fermentation extract used in the cosmetic composition of the present invention can be obtained by adding the medicinal herb to yeast or lactic acid bacteria, fermentation. At this time, the herbal medicines are preferably contained in 10 to 20% by weight in the basal medium.

Specifically, in the case of using yeast as a microorganism, after inoculating the yeast into the basic medium containing the herbal powder at a constant concentration (about 10 ^{5-10 7} cells / mL), pH 5.5-6.5, temperature 25-35 ℃, barrel After culturing under the condition of 0.05 to 0.5 VVM, the fermentation broth can be obtained by centrifugation of the fermentation broth to remove the polymer precipitate and lactic acid bacteria. Incubation time is 30 to 120 hours is good.

When using lactic acid bacteria as microorganisms, inoculate yeast into the basic medium containing the herbal powder at a constant concentration (about 10 ^{5-10 7} cells / mL), and then pH 6.5-7.5, temperature 35-38 ° C., and aeration rate. After culturing while maintaining the conditions of 1VVM, this fermentation broth may be centrifuged to obtain a final herbal fermentation broth extract from which polymer precipitates and lactic acid bacteria are removed. Incubation time is 24 to 120 hours is good.

Herbal fermentation extract obtained as described above is preferably contained in 0.0001 to 100% by weight in the cosmetic composition of the present invention, when the content is less than 0.0001% by weight it is difficult to expect a substantial whitening effect.

The formulation of the cosmetic composition containing the herbal fermented extract of the present invention as an active ingredient is not particularly limited and may be appropriately selected as desired. For example, the cosmetic composition of the present invention may be prepared in the form of external skin ointment, softening longevity, nourishing longevity, nutrition cream, massage cream, essence, pack, emulsion, oil gel and the like. At this time, the external skin ointment may be prepared to contain 50 to 97% by weight of petrolatum and 0.1 to 5% by weight of polyoxyethylene oleyl-ether phosphate in addition to the medicinal herb fermentation extract of the present invention, the flexible cosmetic is fermented herbal medicine of the present invention In addition to the extract, it may be prepared to contain 1 to 10% by weight of polyhydric alcohols (propylene glycol, glycerin, etc.) and 0.05 to 2% by weight of surfactants (polyethylene oleyl ether, polyoxyethylene hydrogenated castor oil, etc.). In addition, nutritional longevity and nourishing cream is 5-20% by weight of oils (squalane, petrolatum, octyldodecanol, etc.) and wax components (cetanol, stearyl alcohol, beeswax, etc.) in addition to the herbal fermentation extract of the present invention It may be prepared to contain a%, essence may be prepared by containing 5 to 30% by weight of polyhydric alcohols such as glycerin, propylene glycol in addition to the herbal fermentation extract of the present invention. Massage cream is prepared by containing 30 to 70% by weight of oil, such as liquid paraffin, petrolatum, isononyl isononanoate in addition to the herbal fermentation extract of the present invention, the pack is polyvinyl alcohol 5-20 in addition to the herbal fermentation extract of the present invention Wash off containing 5-30% by weight of pigments such as kaolin, talc, zinc oxide, titanium dioxide, etc., in addition to the medicinal herb fermentation extract of the present invention in a peel-off pack or a general emulsion cosmetic containing weight% ) Pack.

In addition, the cosmetic composition of the present invention requires oils, water, surfactants, humectants, lower alcohols, thickeners, chelating agents, pigments, preservatives, or fragrances, etc., which are formulated in general skin cosmetics in addition to the components described above in each formulation. It can mix | blend suitably according to the use.

The cosmetic composition of the present invention as described above is excellent in free radical scavenging ability, inhibiting melanin production at the cellular level, and can be added and used in all forms of cosmetics due to its activity, non-irritability, and excellent skin absorption. .

In addition, the cosmetic composition of the present invention has functions such as whitening, skin immunity and physiological activity, antibacterial activity, moisturizing / wrinkle improvement, anti-aging, antioxidant, skin elasticity, exfoliation, diet, nutrition for skin, ultraviolet light protection, etc. There is an excellent advantage.

Hereinafter, preferred examples are provided to help understanding of the present invention, but the following examples are merely to illustrate the present invention, and the scope of the present invention is not limited to the following examples.

EXAMPLE

Example 1. Preparation of Chinese Herbal Fermentation Extract

The dried bones, green beans, white paper, flakes, and chrysanthemum (weights of 2.5: 8: 2.5: 1.3: 1.3, respectively) were chopped and then crushed and stirred with a homomixer to obtain a fine powder. This powdered herbal medicine was again crushed by an atomizer (USA) and passed through a screen (pie 0.8 mm, ROUND HALL). This process was repeated and passed through a 0.3 mm diameter ROUND HALL and filtered through a sieve (standard in tile, 200 mesh) to obtain an ultrafine powder phase. The obtained herbal powder is added to 1.5 L of purified water to be 3% by weight, and the carbon composition, nitrogen source, phosphate, inorganic salts, micronutrients, etc. as a basic composition, using sodium hydroxide to an appropriate pH (5.0 ~ 7.5) Fit. Inoculate Lactobacillus acidophilus in the culture medium to a basic medium containing a crude powder at a constant concentration (about 10 ⁵ to 10 ⁷ cells / ml), maintaining the conditions of pH 5.5 ~ 7.0, temperature 35 ~ 38 ℃, aeration rate 1VVM Incubated for 24 to 120 hours.

The fermentation broth was centrifuged at 10,000 x g for 30 minutes to obtain a final herbal fermentation broth extract from which polymer precipitates and lactic acid bacteria were removed.

(Cytotoxicity)

In order to verify the primary safety as a raw material used in cosmetics, the MTT test method (Mossman T) was cultured by culturing V79-4 cells (Chinese hamster, continuous cell line of lung tissue fibroblasts) on the herbal fermented extract prepared in Example 1 Rapid colorimetric assay for cellular growth & survival: application to proliferation & cytotoxicity assays.Journal of Immunological Methods , 1983, 65, 55-63) was performed to test the cytotoxicity, and the results are shown in Table 1 below. At this time, SLS (sodium lauryl sulfate) and squalane, which is an oil-soluble raw material having excellent stability, were used as a control.

sample IC ₅₀ (%, w / v) SLS 0.005 Squalane 0.05 Chinese Herbal Fermentation Extract 7.00 IC ₅₀ (Inhibitory Concentration 50)-50% cell killing concentration

As shown in Table 1, the IC ₅₀ value of the medicinal herb fermentation extract contained in the cosmetic composition of the present invention as an active ingredient is 7.00% lower cytotoxicity than 1,000 times compared to SLS, and squalane which is a useful raw material having excellent safety. It was confirmed that the cytotoxicity was low because the stability was very high compared to 100 times lower than that.

Allergy Test (LLNA)

Experimental method using acetone: olive oil (4: 1) as a carrier medium to confirm the allergic induction of the herbal fermented extract prepared in Example 1 (Kimber I (1990): Identification of contact allergens using the murine local lymph node assay, J. Appl. Toxicol. 10 (3); 173-180).

First, the herbal fermented extract prepared in Example 1 was prepared in 20 wt%, 40 wt%, and 60 wt% solutions, respectively, and 50 μl was applied to both ears of the mouse (Balb / c) for 3 days. Auricular lymph node was isolated. The isolated lymph nodes were pulverized into a single cell state, incubated for 24 hours with the addition of radioisotope [ ³ H] -methyl thymidine, and then subjected to β-scintillation counter (Beckman LS 6000 TA, USA). The average (cmp) and the degree of amplification (dpm, disintegrations per minute) of the cells were measured, and the results are shown in Table 2 below.

division Lymph node count (10 ⁷ cells / mL) cmp (average) Amplification Acetone: Olive Oil (4: 1) 1.72 2880 Transportation Chinese Herb Fermented Extract 20% 2.38 3360 1.4 Chinese Herb Fermented Extract 40% 2.75 3280 1.6 Herbal Medicine Fermented Extract 60% 3.59 4890 1.7

As shown in Table 2, the herbal fermented extract used in the cosmetic composition of the present invention was shown to have an amplification degree of 2 or less, which does not cause allergy.

(Skin irritant)

For skin irritation test of the medicinal herb fermentation extract prepared in Example 1, patch test using guinea pig (Guinea Pig) (① Draize, JH (1959): Dermal toxicity.Assoc.Food and Drug officials, US.Appraisal of the safety of chemicals in Food, Drugs and Cosmetics., Pp 46-59, Texas State Dept of Health, Austin, Texas. (2) Federal Register (1973): Method of testing primary irritant substances 38 (187): pp1500-. 1541) was carried out as follows.

First, the hair at the sample application site (back) was removed and acclimated to the environment for 24 hours to minimize skin irritation. Then, the sample application site was set (1.5 cm × 1.5 cm) and the herbal fermented extract prepared in Example 1 (0.5% by weight, 5.0% by weight, 50.0% by weight) and the gauze were applied, followed by evaporation of the sample and Sealed with solid foil to prevent loss and fixed with elastic bandage for 48 hours. After fixing for 48 hours, the closed patch was removed, and the primary cutaneous irritation index (PII) was determined at 2 hours and 24 hours (48 hours and 72 hours after the patch), and the results are shown in Table 3 below. . At this time, as a control, dry the fine bone, mung bean, white paper, sculpture, and natural powder in the same ratio as in Example 1, and then chop the extract, and then add the extraction solvent (distilled water: 1,3-butylene glycol = 7: 3) The extraction was performed at 30% by weight. After cooling for 3 days, the precipitate was filtered with a 0.2 μm filter to prevent precipitation, and the medicinal herb extract prepared by subtracting UV ultraviolet rays for 3 days was used for bactericidal effect.

division Irritation index (PII) Stimulus Control Herb Extract 0.50 Microstimulation 0.5% Medicinal Herb Fermented Extract 0.52 Microstimulation 5.0% Herbal Medicine Fermented Extract 0.53 Microstimulation 50.0% Herbal Medicine Fermented Extract 0.53 Microstimulation

As shown in Table 3, it was found that the herbal extracts used in the cosmetic composition of the present invention can be safely applied to the skin due to fine skin irritation when the stimulation index is used within 50%.

(Free radical scavenging ability)

The free radical scavenging ability of the medicinal herb fermentation extract prepared in Example 1 was measured by the 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) method as follows (Blois, M.S. Nature 181, 1190 (1958)). DPPH is a relatively stable free radical that exhibits maximum absorption at 517 nm when present in the radical state and loses its absorbance when erased. DPPH was used by Sigma Co., Ltd. and dissolved in methyl alcohol at a concentration of 0.15 mM.

First, the medicinal herb fermentation extract prepared in Example 1 was put in 100 μl into a well of a 96 well plate. After 100 μl of DPPH solution was added thereto, the mixture was left at room temperature for 30 minutes and the absorbance at 517 nm was measured using a Micro plate reader (BioTek EL-340). At this time, a methyl alcohol was used as a control. The concentration of the herbal fermented extract when the absorbance of the treatment of the herbal fermented extract is half the absorbance of the control group was expressed as IC ₅₀ (inhibitory concentration 50), the results are shown in Table 4 below.

division IC ₅₀ Vitamin c 0.0005% Chinese Herbal Fermentation Extract 0.0009% Methyl alcohol 0.0025% IC ₅₀ (Inhibitory Concentration 50)-50% cell killing concentration

As shown in Table 4, the herbal fermented extract used in the cosmetic composition of the present invention was found to be a very powerful free radical scavenger, and excellent in its sustainability.

(Melanin production inhibitory effect at the cellular level)

The herbal fermentation extract prepared in Example 1 was added to the culture solution of rat melanoma cells (B-16 mouse melanoma cells) to test the whitening effect at the cellular level (Lotan R., Lotan D. Cancer Res. 40 : 3345-350, 1980).

Prepare the herbal fermentation extract prepared in Example 1 in 5% by weight, 0.5% by weight, 0.05% by weight, 0.005% by weight, respectively, and added to the culture medium of B-16 melanoma cells with hydroquinone aqueous solution 3 After daily culture, the cells were treated with trypsin, removed from the culture vessel, centrifuged, and melanin was extracted. 1 mL of sodium hydroxide solution (1N concentration) was added thereto, and the mixture was boiled for 10 minutes to express the amount of melanin as absorbance per unit cell count (10 ⁶ cells). The relative melanin production relative to the control group was calculated as inhibition rate (%). And the results are shown in Table 5 below. At this time, the control group was made without additives without adding the medicinal herb fermentation extract.

division Inhibition Rate (%) Control group (no addition) - Chinese Herb Fermented Extract 5% 37 Chinese Herbal Fermented Extract 0.5% 28 Herbal Medicine Ferment Extract 0.05% 41 Herbal Medicine Ferment Extract 0.005% 33

As shown in Table 5, it was confirmed that the herbal fermented extract used in the cosmetic composition of the present invention has a very strong melanin production inhibitory ability against the cultured melanoma cells.

Examples 2-4 and Comparative Example 1

According to the composition of Table 6, Examples 2 to 4 were combined with the herbal medicine fermentation extract in a general manner. On the other hand, Comparative Example 1 is a comparative sample that does not contain the medicinal herb fermentation extract, after heating and dissolving the aqueous phase and oil phase to 70 ~ 75 ℃, respectively, add the oil phase to the aqueous phase and emulsified for 10 minutes under the homomixer 6,000 rpm 30 The oil-in-water emulsion was prepared by cooling to ° C.

The units in Table 6 below are by weight.

division Example 2 Example 3 Example 4 Comparative Example 1    Awards Purified water Remaining amount Remaining amount Remaining amount Remaining amount Triethanolamine 0.15 0.15 0.15 0.15 Carboxy vinyl polymer ¹ 15 15 15 15 Dark glycerin 6 6 6 6 Propylene glycol 4 4 4 4 Paraoxybenzoic Acid Ester 0.2 0.2 0.2 0.2 Chinese Herbal Fermentation Extract 0.05 1.0 5.0 -     Paid Cetostearyl alcohol One One One One Glyceryl Monostearate One One One One Sorbitan monosulfate ² One One One One POE (20) sorbitan monostearate 1.5 1.5 1.5 1.5 Paraoxybenzoic acid propyl 0.1 0.1 0.1 0.1 Isocetil Myristate 5 5 5 5 Isocetyloctanoate ³ 5 5 5 5 Squalane 5 5 5 5 Spices Quantity Quantity Quantity Quantity 1. Carboxy vinyl polymer-Carbopol 941 (BFGoodrich, USA) 1 wt% aqueous solution 2. Monostearate sorbitan-Aracel 60 (ICA) 3.Isocetyl Octanoate-ICEH, Nihon KoKyu Alcohol, Japan

(Color Deposition)

Twenty healthy men and women were selected to attach aluminum foil in two rows of six holes with a diameter of 7 mm in the lower part of both arms. Investigate. The irradiation site was washed well with 70% ethanol aqueous solution before irradiation. Twice a day from 3 days before the irradiation to 3 weeks after the irradiation, the same oil-based emulsions containing the Chinese herbal fermented extracts prepared according to Examples 2 to 4 and Comparative Example 1 and the substrates without the respective extracts were prepared in pairs. Was applied. For each, the degree of pigmentation was visually determined, and Examples 2 to 4 evaluated the degree of suppression of pigmentation in comparison with the comparative example in three steps of distinct effects, effects, and no differences, and the results are shown in Table 7 below. Shown in

division Distinct Effect (People) Effective (persons) No difference (persons) Example 2 0 5 15 Example 3 One 8 11 Example 4 3 6 11 Comparative Example 1 5 8 7

As shown in Table 7, the Chinese herbal fermented extract-containing oil-in-water emulsion prepared according to the present invention showed a whitening effect on at least 8 or more of 20 subjects. 3 and 4 showed 60% and 65% inhibition of color deposition, respectively, compared to Comparative Example 1, and did not show any side effects in the skin, so that the herbal medicine fermentation extract used in the cosmetic composition of the present invention was very safe and effective. It was found to be an excellent blemish, freckle improvement or skin whitening cosmetic.

(Antibacterial activity)

In order to measure the antimicrobial activity of the medicinal herb fermentation extract prepared in Example 1 three kinds of bacteria (E. coli (E. coli), P.aeruginosa , S.aureus ), a fungus ( A.niger ) pre-cultured, Evenly inoculated to the plate (plate) 0.5%, 5%, 50% herbal extract prepared in Example 1 0.5% ethyl paraben (ethyl paraben), 0.5% propyl paraben (prophyl paraben), methyl paraben (methyl paraben) 0.5% was added to 100 μl of paper disc, respectively, and the antimicrobial activity was evaluated in the growth zone where growth was inhibited. The results are shown in Table 8 below.

-And + in Table 8 indicate the degree of growth.

division E.coli P.aeruginosa S.aureus A.niger Chinese Herb Ferment Extract 0.5% ++ + + + Chinese Herb Fermented Extract 5% + - - + Chinese Herb Fermented Extract 50% - - - - Ethyl paraben 0.5% - - - - Propyl Paraben 0.5% - - - - Methyl paraben 0.5% - - - -

As shown in Table 8, the herbal fermented extract used in the cosmetic composition of the present invention is three bacteria ( E. coli (E. coli), P.aeruginosa , S.aureus ) and one fungus at a concentration of 50% by weight or more ( A.niger ) was able to confirm that the antimicrobial activity. Through these results, it was confirmed that the cosmetics safe to contaminate the microbial strains when the medicinal herb fermentation extract of the present invention 50% by weight or more used.

The cosmetic composition according to the present invention is non-irritating, easily and safely penetrates into the skin, and does not cause skin diseases, and has an excellent function of inhibiting antioxidant activity and tyrosinase activity and significantly inhibiting melanin production, thereby improving the whitening effect and its effects. Not only can improve the sustainability, it has an excellent absorption of the skin compared to the conventional whitening agent, there is no cytotoxicity, allergy, skin irritation, human irritation and the like can be safely used as a cosmetic for whitening with antibacterial activity.

The present invention described above is not limited to the above-described embodiments, and various substitutions, modifications, and changes can be made without departing from the technical spirit of the present invention. It is obvious to those who have it.

Claims (8)

Cosmetic composition characterized in that it comprises a herbal medicine fermented extract obtained by adding and culturing the herbal medicine to yeast or lactic acid bacteria as an active ingredient. The method of claim 1, Cosmetic composition, characterized in that at least one selected from the group consisting of herbal, green beans, white paper, sculptor, and natural powder. The method of claim 1, Cosmetic composition, characterized in that the yeast is selected from the group consisting of Saccharomyces sp ., Schizosaccharomyces sp ., Torulopsis sp ., Rhodotorula sp ., And Candida sp . The method of claim 1, Cosmetic composition, characterized in that the lactic acid bacteria is selected from the group consisting of Lactobacillus sp ., Streptococcus sp ., Leuconostoc sp ., And Bifidobacteria sp . The method of claim 1, Cosmetic composition according to claim 1, wherein the herbal fermented extract is contained in an amount of 0.0001 to 100% by weight in the cosmetic composition. The method of claim 1, The cosmetic composition is a cosmetic composition, characterized in that the skin external ointment, flexible cosmetics, nourishing cosmetics, nutrition cream, massage cream, essence, pack, emulsion, or oil gel formulation. The method of claim 1, The cosmetic composition further comprises at least one additive selected from the group consisting of oil, water, surfactants, moisturizers, lower alcohols, thickeners, chelating agents, pigments, preservatives, and fragrances. The method of claim 1, The cosmetic composition for anti-aging, whitening, skin immunity increase, antimicrobial activity, moisturizing, antioxidant, exfoliation, diet, skin nutrition supply, UV light protection function, characterized in that for cosmetics.