CN111110620A - Anti-aging, freckle-removing and anti-wrinkle cosmetic - Google Patents
Anti-aging, freckle-removing and anti-wrinkle cosmetic Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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Abstract
The invention discloses an anti-aging, freckle-removing and anti-wrinkle cosmetic which is characterized by comprising, by weight, 2-5 parts of tetrahydroxystilbene glycoside modified β -carotene, 3-6 parts of β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, 1-3 parts of norbornene-2-methylamine modified carnosic acid, 1-3 parts of Chinese herbal medicine extracts, 3-8 parts of glycerol, 0.5-1.5 parts of an emulsifier and 30-40 parts of water.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-aging, freckle-removing and anti-wrinkle cosmetic and a preparation method thereof.
Background
In recent years, people have faster pace of life, working pressure and living pressure are increasing day by day, and skin problems of people are gradually highlighted due to the generation of environmental pollution and food problems. The skin is a window of ages, wrinkles which easily reflect the ages and the ages of people appear on the skin along with the increase of the ages, people, especially women who love beauty, cause serious injuries, and the problem that people who love beauty have to face how to effectively prevent the ages, the wrinkles and the rejuvenescence is solved.
The wrinkles refer to small fine lines and wrinkles formed by the skin affected by external environment, which form free radicals, the free radicals destroy collagen and active substances in normal cell membrane tissues and oxidize cells. Facial wrinkles are divided into two types, atrophied wrinkles and hypertrophic wrinkles. Atrophic wrinkles refer to wrinkles that appear on thin, chapped and dry skin, such as countless fine wrinkles around the eyes; hypertrophic wrinkles are wrinkles that are indicated on oily skin, are not numerous and have dense and deep texture. At present, anti-wrinkle skin care mainly depends on cosmetics, and the cosmetics are used as industries engaged in human beauty industry, are particularly influenced by current green natural plants and Chinese medicinal culture, deepen understanding of life science by people, can meet the pursuit of beauty of people from the aspects of green, nature, safety and environmental protection, and become the focus of attention of people to the connotation of cosmetic quality and functional appeal in new period.
Most of cosmetics with an anti-wrinkle function in the prior art are chemical synthesis agents, and can achieve whitening or anti-wrinkle effects in a short term, but are harmful to the skin in a long term, and easily cause skin irritation, allergy and other problems. In addition, the effective components in the anti-wrinkle cosmetics on the market are only partially absorbed by the skin, but mostly remain on the surface of the skin, so that the problems of waste and residue are caused. More importantly, some moisturizing components are too greasy, the skin cannot be fully absorbed, and formed grease is accumulated in pores, so that the pores are easily blocked; the improvement of the obvious morphological defects of fine wrinkles, acne scars and the like is not effective, and even the fine wrinkles are sometimes more prominent.
The Chinese patent with the application number of 201610193311.3 discloses a natural anti-wrinkle skin-tendering Chinese angelica skin care product and a preparation method thereof, the skin care product comprises Chinese patent medicine components and a matrix component, and the Chinese patent medicine components are prepared from the following raw materials: angelica, peach kernel, dandelion, spina date seed, ligusticum wallichii, schisandra chinensis, bletilla striata, mung bean, rose, almond, wheat germ oil, perilla leaf, lotus leaf, astragalus mongholicus, mullein, purslane herb, tremella, astringent persimmon peel, Chinese yam, wild kudzu root, sea cucumber, okra, seaweed, fish skin and a proper amount of deionized water. The invention selects the angelica polysaccharide as a functional factor for eliminating free radicals, compounds other components for improving the dormancy and activity of organisms, combines the functions of tonifying qi, activating blood, promoting cell regeneration, enhancing immunity and the like with the functions of eliminating deep garbage of skin and repairing tissues, achieves the effect of combining the functions of both specimens and the functions, maintains the balance and the stability of an antioxidant defense system, and has the functions of resisting wrinkles and tendering skin. However, the components are complicated, and the transdermal absorption effect and the anti-wrinkle skin care effect are to be further improved.
Therefore, the anti-wrinkle cosmetic with remarkable anti-aging, freckle-removing and anti-wrinkle effects, good transdermal effect and no stimulation to skin is developed, can effectively beautify and protect skin, meets the market demand, has wide market value and application prospect, and has very important significance for promoting the development of the anti-wrinkle cosmetic industry.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides the anti-aging, freckle-removing and anti-wrinkle cosmetic and the preparation method thereof, and the preparation method is simple and easy to implement, low in preparation cost, high in preparation efficiency and suitable for industrial production; the prepared anti-wrinkle cosmetic has obvious effects of resisting aging, removing freckles and resisting wrinkles, has good transdermal effect, has no stimulation to skin, and can effectively beautify and protect skin.
In order to achieve the purpose, the anti-aging, freckle-removing and anti-wrinkle cosmetic adopts the technical scheme that the anti-aging, freckle-removing and anti-wrinkle cosmetic is characterized by comprising the following components, by weight, 2-5 parts of tetrahydroxystilbene glucoside modified β -carotene, 3-6 parts of β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, 1-3 parts of norbornene-2-methylamine modified carnosic acid, 1-3 parts of Chinese herbal medicine extracts, 3-8 parts of glycerol, 0.5-1.5 parts of an emulsifier and 30-40 parts of water.
Preferably, the emulsifier is one or more of glyceryl monostearate, stearyl alcohol or lanolin.
Preferably, the preparation method of the tetrahydroxystilbene glycoside modified β -carotene comprises the following steps of dissolving tetrahydroxystilbene glycoside and β -carotene in a high boiling point solvent to form a solution under the atmosphere of nitrogen or inert gas, adding the solution into a three-neck flask provided with a reflux condenser tube and an electric stirrer, carrying out reflux stirring reaction at 105-115 ℃ for 5-7 hours, and then carrying out rotary evaporation to remove the solvent to obtain the tetrahydroxystilbene glycoside modified β -carotene.
Preferably, the mole ratio of the tetrahydroxystilbene glycoside to the β -carotene to the high boiling point solvent is 2:1 (10-15).
Preferably, the high boiling point solvent is at least one of dimethyl sulfoxide, N-dimethylformamide, N-dimethylacetamide and N-methylpyrrolidone.
Preferably, the inert gas is one of helium, neon and argon.
Preferably, the preparation method of β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin comprises the following steps of adding β -nicotinamide adenine dinucleotide and epoxy cyclodextrin into N, N-dimethylformamide, stirring and reacting for 4-6 hours at 70-80 ℃, and then removing the N, N-dimethylformamide by rotary evaporation to obtain β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin.
Preferably, the mass ratio of the β -nicotinamide adenine dinucleotide, the epoxy cyclodextrin and the N, N-dimethylformamide is 1 (3-5) to (12-20).
Preferably, the preparation method of the norbornene-2-methylamine modified carnosic acid comprises the following steps: adding norbornene-2-methylamine, carnosic acid, 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and N-hydroxy benzotriazole into dimethyl sulfoxide, stirring and reacting for 4-6 hours at 25-45 ℃, then performing rotary evaporation to remove dimethyl sulfoxide, then adding dichloromethane and water in a mass ratio of 1:3, taking an oil phase in a layering manner, removing water by using anhydrous magnesium sulfate, filtering, taking a filtrate, and performing rotary evaporation to remove dichloromethane to obtain the norbornene-2-methylamine modified carnosic acid.
Preferably, the molar ratio of the norbornene-2-methylamine, the carnosic acid, the 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride, the N-hydroxybenzotriazole and the dimethyl sulfoxide is 1:1:0.5:0.6 (6-10).
Preferably, the Chinese herbal medicine extract is prepared by boiling the following raw material medicines in parts by weight with water and then extracting: 3-6 parts of angelica dahurica, 1-4 parts of magnolia flower, 3-6 parts of magnolia bark, 2-5 parts of dried purple raisin, 1-3 parts of polygonatum odoratum, 2-6 parts of asarum, 2-5 parts of astragalus membranaceus and 1-3 parts of radix ophiopogonis.
The invention also aims to provide a preparation method of the anti-aging freckle-removing and anti-wrinkle cosmetic, which is characterized by comprising the following steps of: mixing the raw materials in parts by weight, stirring at 65-85 deg.C for 3-5 hr, sterilizing, inspecting, discharging, and packaging.
Adopt the produced beneficial effect of above-mentioned technical scheme to lie in:
(1) the preparation method of the anti-aging, freckle-removing and anti-wrinkle cosmetic provided by the invention is simple and feasible, low in preparation cost, high in preparation efficiency and suitable for industrial production.
(2) The anti-aging, freckle-removing and anti-wrinkle cosmetic provided by the invention overcomes the problems that the anti-wrinkle cosmetic in the prior art easily causes skin irritation, allergy and the like, active ingredients are only partially absorbed by skin, most of the active ingredients are only remained on the surface of the skin, some moisturizing ingredients are too greasy, the skin cannot be fully absorbed, and formed grease is accumulated in pores to easily cause the problem of pore blockage; the skin care cream has the advantages of obvious anti-aging, freckle-removing and anti-wrinkle effects, good transdermal effect, no stimulation to skin and effective beauty and skin care.
(3) According to the anti-aging freckle-removing and anti-wrinkle cosmetic provided by the invention, the added tetrahydroxystilbene glucoside modified β -carotene effectively combines the beneficial properties of phenols and β -carotene, free radicals can be effectively eliminated, the wrinkle removing effect of the cosmetic is further remarkable, the introduced glucoside group has a good moisturizing effect, and has strong moisture increasing capacity and a continuous water locking effect, besides, the substance and other components have synergistic effect, the immunity of skin to infection caused by bacteria and fungi can be effectively enhanced, and the skin can be lubricated, sufficiently moisturized and rich in elasticity.
(4) The anti-aging freckle-removing and anti-wrinkle cosmetic provided by the invention is characterized in that β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin is added and is smeared on the surface of skin to form a functional film layer, so that the effective components are promoted to permeate deep into the skin, and simultaneously the garbage discharged by the skin is adsorbed, so that the anti-wrinkle and skin-tendering effects are improved, the cosmetic is close to the pH value of the skin due to the synergistic effect with other components, the skin is not subjected to allergic reaction while the skin is anti-wrinkle, deoiled and moisturized, the anti-wrinkle effect is better due to the modification of β -nicotinamide adenine dinucleotide, the cyclodextrin can play a role in moisturizing and can provide nutrition for the skin.
(5) The added norbornene-2-methylamine modified carnosic acid can improve the skin absorption and transdermal capacity, and has the functions of resisting oxidation and delaying aging; the Chinese herbal medicine extract combines the advantages of various raw material medicines, is reasonably compatible, has obvious effects of resisting wrinkles, removing freckles, moisturizing and protecting skin, particularly contains the components such as procyanidine, resveratrol, quercetin, tannin, glucose, polyphenol and the like in the purple raisin added in a synergistic manner with other components, can effectively repair and supplement damaged cell tissues, improves the skin reconstruction capability, slows down the generation of wrinkles, removes dark pigments, enables the skin to be fresh and active, and has bright and clear skin color.
Detailed Description
In order to make the technical solutions of the present invention better understood and make the above features, objects, and advantages of the present invention more comprehensible, the present invention is further described with reference to the following examples. The examples are intended to illustrate the invention only and are not intended to limit the scope of the invention.
The preparation of the epoxycyclodextrins of the present invention referred to in the following examples is described in: 9-13 parts of synthesis of Zhao Shuhui, synthesis of epoxy cyclodextrin and silk grafting [ J ] printing and dyeing in Huang Liang morning (2010 (05)); other raw materials were all purchased commercially.
Example 1
An anti-aging, freckle-removing and anti-wrinkle cosmetic comprises, by weight, 2 parts of tetrahydroxystilbene glucoside modified β -carotene, 3 parts of β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, 1 part of norbornene-2-methylamine modified carnosic acid, 1 part of a Chinese herbal medicine extract, 3 parts of glycerol, 0.5 part of glycerol monostearate and 30 parts of water.
The preparation method of the modified β -carotene with tetrahydroxystilbene glycoside comprises the following steps of dissolving tetrahydroxystilbene glycoside and β -carotene in dimethyl sulfoxide in a nitrogen atmosphere to form a solution, adding the solution into a three-neck flask provided with a reflux condenser tube and an electric stirrer, carrying out reflux stirring reaction for 5 hours at 105 ℃, and then carrying out rotary evaporation to remove the solvent to obtain the modified β -carotene with tetrahydroxystilbene glycoside, β -carotene and dimethyl sulfoxide, wherein the molar ratio of the tetrahydroxystilbene glycoside to the dimethyl sulfoxide is 2:1: 10.
The preparation method of the β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin comprises the following steps of adding β -nicotinamide adenine dinucleotide and epoxy cyclodextrin into N, N-dimethylformamide, stirring and reacting for 4 hours at 70 ℃, and then removing the N, N-dimethylformamide through rotary evaporation to obtain β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, wherein the mass ratio of the β -nicotinamide adenine dinucleotide, the epoxy cyclodextrin and the N, N-dimethylformamide is 1:3: 12.
The preparation method of the norbornene-2-methylamine modified carnosic acid comprises the following steps: adding norbornene-2-methylamine, carnosic acid, 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and N-hydroxy benzotriazole into dimethyl sulfoxide, stirring and reacting for 4 hours at 25 ℃, then performing rotary evaporation to remove dimethyl sulfoxide, then adding dichloromethane and water in a mass ratio of 1:3, taking an oil phase in a layering manner, removing water by using anhydrous magnesium sulfate, filtering, taking a filtrate, and performing rotary evaporation to remove dichloromethane to obtain norbornene-2-methylamine modified carnosic acid; the molar ratio of the norbornene-2-methylamine, the carnosic acid, the 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride, the N-hydroxybenzotriazole and the dimethyl sulfoxide is 1:1:0.5:0.6: 6.
The Chinese herbal medicine extract is prepared by boiling the following raw materials in parts by weight with water and then extracting: 3 parts of angelica dahurica, 1 part of biond magnolia flower, 3 parts of magnolia bark, 2 parts of purple raisin, 1 part of polygonatum, 2 parts of asarum, 2 parts of astragalus and 1 part of ophiopogon root.
A preparation method of the anti-aging, freckle-removing and anti-wrinkle cosmetic comprises the following steps: mixing the raw materials in parts by weight, stirring at 65 ℃ for 3 hours, sterilizing, inspecting, discharging, and filling.
Example 2
An anti-aging, freckle-removing and anti-wrinkle cosmetic comprises, by weight, 3 parts of tetrahydroxystilbene glucoside modified β -carotene, 4 parts of β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, 1.5 parts of norbornene-2-methylamine modified carnosic acid, 1.5 parts of Chinese herbal medicine extracts, 4 parts of glycerol, 0.7 part of octadecanol and 33 parts of water.
The preparation method of the tetrahydroxystilbene glycoside modified β -carotene comprises the following steps of dissolving tetrahydroxystilbene glycoside and β -carotene in N, N-dimethylformamide under the atmosphere of helium to form a solution, adding the solution into a three-neck flask provided with a reflux condenser tube and an electric stirrer, carrying out reflux stirring reaction for 5.5 hours at 108 ℃, and then carrying out rotary evaporation to remove the solvent to obtain the tetrahydroxystilbene glycoside modified β -carotene, wherein the molar ratio of the tetrahydroxystilbene glycoside, the β -carotene to the N, N-dimethylformamide is 2:1: 11.
The preparation method of the β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin comprises the following steps of adding β -nicotinamide adenine dinucleotide and epoxy cyclodextrin into N, N-dimethylformamide, stirring and reacting for 4.5 hours at 72 ℃, and then removing the N, N-dimethylformamide through rotary evaporation to obtain β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, wherein the mass ratio of the β -nicotinamide adenine dinucleotide, the epoxy cyclodextrin and the N, N-dimethylformamide is 1:3.5: 14.
The preparation method of the norbornene-2-methylamine modified carnosic acid comprises the following steps: adding norbornene-2-methylamine, carnosic acid, 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and N-hydroxy benzotriazole into dimethyl sulfoxide, stirring and reacting for 4.5 hours at 30 ℃, then performing rotary evaporation to remove the dimethyl sulfoxide, then adding dichloromethane and water in a mass ratio of 1:3, taking an oil phase in a layering manner, removing water by using anhydrous magnesium sulfate, filtering, taking a filtrate, and performing rotary evaporation to remove the dichloromethane to obtain norbornene-2-methylamine modified carnosic acid; the molar ratio of the norbornene-2-methylamine, the carnosic acid, the 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride, the N-hydroxybenzotriazole and the dimethyl sulfoxide is 1:1:0.5:0.6: 7.
The Chinese herbal medicine extract is prepared by boiling the following raw materials in parts by weight with water and then extracting: 4 parts of angelica dahurica, 2 parts of biond magnolia flower, 4 parts of magnolia bark, 3 parts of purple raisin, 1.5 parts of polygonatum, 3 parts of asarum, 3 parts of astragalus root and 1.5 parts of dwarf lilyturf tuber.
A preparation method of the anti-aging, freckle-removing and anti-wrinkle cosmetic comprises the following steps: mixing the raw materials in parts by weight, stirring at 70 ℃ for 3.5 hours, sterilizing, inspecting, discharging, and packaging.
Example 3
An anti-aging, freckle-removing and anti-wrinkle cosmetic comprises, by weight, 3.5 parts of tetrahydroxystilbene glycoside modified β -carotene, 4.5 parts of β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, 2 parts of norbornene-2-methylamine modified carnosic acid, 2 parts of Chinese herbal medicine extracts, 5.5 parts of glycerol, 1 part of lanolin and 35 parts of water.
The preparation method of the tetrahydroxystilbene glycoside modified β -carotene comprises the following steps of dissolving tetrahydroxystilbene glycoside and β -carotene in N, N-dimethylacetamide under the atmosphere of neon to form a solution, adding the solution into a three-neck flask provided with a reflux condenser tube and an electric stirrer, carrying out reflux stirring reaction for 6 hours at 110 ℃, and then carrying out rotary evaporation to remove the solvent to obtain the tetrahydroxystilbene glycoside modified β -carotene, wherein the molar ratio of the tetrahydroxystilbene glycoside to the β -carotene to the N, N-dimethylacetamide is 2:1: 13.
The preparation method of the β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin comprises the following steps of adding β -nicotinamide adenine dinucleotide and epoxy cyclodextrin into N, N-dimethylformamide, stirring and reacting for 5 hours at 75 ℃, and then removing the N, N-dimethylformamide through rotary evaporation to obtain β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, wherein the mass ratio of the β -nicotinamide adenine dinucleotide, the epoxy cyclodextrin and the N, N-dimethylformamide is 1:4: 17.
The preparation method of the norbornene-2-methylamine modified carnosic acid comprises the following steps: adding norbornene-2-methylamine, carnosic acid, 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and N-hydroxy benzotriazole into dimethyl sulfoxide, stirring and reacting for 5 hours at 35 ℃, then performing rotary evaporation to remove dimethyl sulfoxide, then adding dichloromethane and water in a mass ratio of 1:3, taking an oil phase in a layering manner, removing water by using anhydrous magnesium sulfate, filtering, taking a filtrate, and performing rotary evaporation to remove dichloromethane to obtain norbornene-2-methylamine modified carnosic acid; the molar ratio of the norbornene-2-methylamine, the carnosic acid, the 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride, the N-hydroxybenzotriazole and the dimethyl sulfoxide is 1:1:0.5:0.6: 8.
The Chinese herbal medicine extract is prepared by boiling the following raw materials in parts by weight with water and then extracting: 4.5 parts of angelica dahurica, 2.5 parts of biond magnolia flower, 4.5 parts of magnolia bark, 3.5 parts of purple raisin, 2 parts of polygonatum, 4 parts of asarum, 3.5 parts of astragalus and 2 parts of dwarf lilyturf tuber.
A preparation method of the anti-aging, freckle-removing and anti-wrinkle cosmetic comprises the following steps: mixing the raw materials in parts by weight, stirring at 75 ℃ for 4 hours, sterilizing, inspecting, discharging, and filling.
Example 4
An anti-aging, freckle-removing and anti-wrinkle cosmetic comprises, by weight, 4.5 parts of tetrahydroxystilbene glycoside modified β -carotene, 5.5 parts of β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, 2.5 parts of norbornene-2-methylamine modified carnosic acid, 2.5 parts of Chinese herbal medicine extracts, 7 parts of glycerol, 1.4 parts of an emulsifier and 38 parts of water, wherein the emulsifier is prepared by mixing glyceryl monostearate, octadecanol and lanolin in a mass ratio of 1:2: 4.
The preparation method of the tetrahydroxystilbene glycoside modified β -carotene comprises the following steps of dissolving tetrahydroxystilbene glycoside and β -carotene in a high-boiling-point solvent in an argon atmosphere to form a solution, adding the solution into a three-neck flask provided with a reflux condenser tube and an electric stirrer, carrying out reflux stirring reaction for 6.7 hours at 113 ℃, and then carrying out rotary evaporation to remove the solvent to obtain the tetrahydroxystilbene glycoside modified β -carotene, wherein the molar ratio of the tetrahydroxystilbene glycoside, the β -carotene to the high-boiling-point solvent is 2:1:14, and the high-boiling-point solvent is formed by mixing dimethyl sulfoxide, N-dimethylformamide, N-dimethylacetamide and N-methylpyrrolidone according to a mass ratio of 1:3:2: 2.
The preparation method of the β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin comprises the following steps of adding β -nicotinamide adenine dinucleotide and epoxy cyclodextrin into N, N-dimethylformamide, stirring and reacting for 5.8 hours at 78 ℃, and then removing the N, N-dimethylformamide through rotary evaporation to obtain β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, wherein the mass ratio of the β -nicotinamide adenine dinucleotide, the epoxy cyclodextrin and the N, N-dimethylformamide is 1:4.5: 18.
The preparation method of the norbornene-2-methylamine modified carnosic acid comprises the following steps: adding norbornene-2-methylamine, carnosic acid, 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and N-hydroxy benzotriazole into dimethyl sulfoxide, stirring and reacting for 5.8 hours at 43 ℃, then performing rotary evaporation to remove the dimethyl sulfoxide, then adding dichloromethane and water in a mass ratio of 1:3, taking an oil phase in a layering manner, removing water by using anhydrous magnesium sulfate, filtering, taking a filtrate, and performing rotary evaporation to remove the dichloromethane to obtain norbornene-2-methylamine modified carnosic acid; the molar ratio of the norbornene-2-methylamine, the carnosic acid, the 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride, the N-hydroxybenzotriazole and the dimethyl sulfoxide is 1:1:0.5:0.6: 9.
The Chinese herbal medicine extract is prepared by boiling the following raw materials in parts by weight with water and then extracting: 5 parts of angelica dahurica, 3 parts of biond magnolia flower, 5 parts of magnolia bark, 4 parts of purple raisin, 2.5 parts of polygonatum, 5 parts of asarum, 4.5 parts of astragalus root and 2.5 parts of dwarf lilyturf tuber.
A preparation method of the anti-aging, freckle-removing and anti-wrinkle cosmetic comprises the following steps: mixing the raw materials in parts by weight, stirring at 83 ℃ for 4.7 hours, sterilizing, inspecting, discharging, and packaging.
Example 5
An anti-aging, freckle-removing and anti-wrinkle cosmetic comprises, by weight, 5 parts of tetrahydroxystilbene glucoside modified β -carotene, 6 parts of β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, 3 parts of norbornene-2-methylamine modified carnosic acid, 3 parts of a Chinese herbal medicine extract, 8 parts of glycerol, 1.5 parts of glycerol monostearate and 40 parts of water.
The preparation method of the tetrahydroxystilbene glycoside modified β -carotene comprises the following steps of dissolving tetrahydroxystilbene glycoside and β -carotene in N-methyl pyrrolidone in a nitrogen atmosphere to form a solution, adding the solution into a three-neck flask provided with a reflux condenser tube and an electric stirrer, carrying out reflux stirring reaction for 7 hours at 115 ℃, and then carrying out rotary evaporation to remove the solvent to obtain the tetrahydroxystilbene glycoside modified β -carotene, wherein the molar ratio of the tetrahydroxystilbene glycoside, the β -carotene to the N-methyl pyrrolidone is 2:1: 15.
The preparation method of the β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin comprises the following steps of adding β -nicotinamide adenine dinucleotide and epoxy cyclodextrin into N, N-dimethylformamide, stirring and reacting for 6 hours at 80 ℃, and then removing the N, N-dimethylformamide through rotary evaporation to obtain β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, wherein the mass ratio of the β -nicotinamide adenine dinucleotide, the epoxy cyclodextrin and the N, N-dimethylformamide is 1:5: 20.
The preparation method of the norbornene-2-methylamine modified carnosic acid comprises the following steps: adding norbornene-2-methylamine, carnosic acid, 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and N-hydroxy benzotriazole into dimethyl sulfoxide, stirring and reacting for 6 hours at 45 ℃, then performing rotary evaporation to remove dimethyl sulfoxide, then adding dichloromethane and water in a mass ratio of 1:3, taking an oil phase in a layering manner, removing water by using anhydrous magnesium sulfate, filtering, taking a filtrate, and performing rotary evaporation to remove dichloromethane to obtain norbornene-2-methylamine modified carnosic acid; the molar ratio of the norbornene-2-methylamine, the carnosic acid, the 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride, the N-hydroxybenzotriazole and the dimethyl sulfoxide is 1:1:0.5:0.6: 10.
The Chinese herbal medicine extract is prepared by boiling the following raw materials in parts by weight with water and then extracting: 6 parts of angelica dahurica, 4 parts of biond magnolia flower, 6 parts of magnolia bark, 5 parts of purple raisin, 3 parts of polygonatum, 6 parts of asarum, 5 parts of astragalus and 3 parts of dwarf lilyturf tuber.
A preparation method of the anti-aging, freckle-removing and anti-wrinkle cosmetic comprises the following steps: mixing the raw materials in parts by weight, stirring at 85 ℃ for 5 hours, sterilizing, inspecting, discharging, and filling.
Comparative example 1
An anti-aging, freckle-removing and anti-wrinkle cosmetic has a formula and a preparation method which are basically the same as those of example 1, except that tetrahydroxystilbene glycoside modified β -carotene is not added.
Comparative example 2
An anti-aging, freckle-removing and anti-wrinkle cosmetic has the same formula and preparation method as those of example 1, except that β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin is not added.
Comparative example 3
An anti-aging, freckle-removing and anti-wrinkle cosmetic has a formula and a preparation method which are basically the same as those of example 1, except that norbornene-2-methylamine modified carnosic acid is not added.
Comparative example 4
An anti-aging, freckle-removing and anti-wrinkle cosmetic has the same formula and preparation method as the example 1, and is different from a Chinese herbal medicine extract which is not added with purple raisin.
The anti-wrinkle performance test is carried out on the anti-aging, freckle-removing and anti-wrinkle cosmetics in the examples 1 to 5 and the comparative examples 1 to 4, the test result is shown in the table 1, and the test method is as follows: 270 female volunteers aged 35-45 years and suffering from wrinkles are taken to carry out experiments, the female volunteers are randomly divided into 9 groups, 50 persons in each group are coated on the affected part respectively according to the anti-aging freckle-removing and anti-wrinkle cosmetics of examples 1-5 and comparative examples 1-4, the application is repeated twice a day, 15 days are a treatment course, and the effect is judged after 2 treatment courses.
TABLE 1
As can be seen from Table 1, the anti-aging, freckle-removing and anti-wrinkle cosmetic disclosed by the invention has more excellent anti-wrinkle effect, which is a result of the synergistic effect of the components.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. The anti-aging, freckle-removing and anti-wrinkle cosmetic is characterized by comprising, by weight, 2-5 parts of tetrahydroxystilbene glycoside modified β -carotene, 3-6 parts of β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin, 1-3 parts of norbornene-2-methylamine modified carnosic acid, 1-3 parts of Chinese herbal medicine extracts, 3-8 parts of glycerol, 0.5-1.5 parts of an emulsifier and 30-40 parts of water.
2. The anti-aging, freckle-removing and anti-wrinkle cosmetic according to claim 1, wherein the emulsifier is one or more of glyceryl monostearate, stearyl alcohol or lanolin.
3. The anti-aging, freckle-removing and anti-wrinkle cosmetic as claimed in claim 1, wherein the preparation method of the tetrahydroxystilbene glycoside modified β -carotene comprises the steps of dissolving tetrahydroxystilbene glycoside and β -carotene in a high boiling point solvent to form a solution under nitrogen or inert gas atmosphere, adding the solution into a three-port bottle provided with a reflux condenser tube and an electric stirrer, carrying out reflux stirring reaction at 105-115 ℃ for 5-7 hours, and then carrying out rotary evaporation to remove the solvent to obtain the tetrahydroxystilbene glycoside modified β -carotene.
4. The anti-aging freckle-removing and anti-wrinkle cosmetic according to claim 3, wherein the molar ratio of tetrahydroxystilbene glycoside to β -carotene to high-boiling-point solvent is 2:1 (10-15).
5. The anti-aging, freckle-removing and anti-wrinkle cosmetic according to claim 3, wherein the high-boiling solvent is at least one of dimethyl sulfoxide, N-dimethylformamide, N-dimethylacetamide and N-methylpyrrolidone; the inert gas is one of helium, neon and argon.
6. The anti-aging, freckle-removing and anti-wrinkle cosmetic according to claim 1, wherein the preparation method of the β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin comprises the steps of adding β -nicotinamide adenine dinucleotide and epoxy cyclodextrin into N, N-dimethylformamide, stirring and reacting at 70-80 ℃ for 4-6 hours, and then removing the N, N-dimethylformamide by rotary evaporation to obtain β -nicotinamide adenine dinucleotide modified epoxy cyclodextrin.
7. The anti-aging, freckle-removing and anti-wrinkle cosmetic as claimed in claim 6, wherein the mass ratio of the β -nicotinamide adenine dinucleotide, the epoxy cyclodextrin and the N, N-dimethylformamide is 1 (3-5) to (12-20).
8. The anti-aging, freckle-removing and anti-wrinkle cosmetic according to claim 1, wherein the preparation method of the norbornene-2-methylamine modified carnosic acid comprises the following steps: adding norbornene-2-methylamine, carnosic acid, 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and N-hydroxy benzotriazole into dimethyl sulfoxide, stirring and reacting for 4-6 hours at 25-45 ℃, then performing rotary evaporation to remove dimethyl sulfoxide, then adding dichloromethane and water in a mass ratio of 1:3, taking an oil phase in a layering manner, removing water by using anhydrous magnesium sulfate, filtering, taking a filtrate, and performing rotary evaporation to remove dichloromethane to obtain norbornene-2-methylamine modified carnosic acid; the molar ratio of the norbornene-2-methylamine to the carnosic acid to the 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride to the N-hydroxybenzotriazole to the dimethyl sulfoxide is 1:1:0.5:0.6 (6-10).
9. The anti-aging, freckle-removing and anti-wrinkle cosmetic according to claim 1, wherein the Chinese herbal medicine extract is prepared by decocting the following raw material medicines in parts by weight with water and then extracting: 3-6 parts of angelica dahurica, 1-4 parts of magnolia flower, 3-6 parts of magnolia bark, 2-5 parts of dried purple raisin, 1-3 parts of polygonatum odoratum, 2-6 parts of asarum, 2-5 parts of astragalus membranaceus and 1-3 parts of radix ophiopogonis.
10. The anti-aging freckle-removing and anti-wrinkle cosmetic according to any one of claims 1 to 9, wherein the preparation method of the anti-aging freckle-removing and anti-wrinkle cosmetic comprises the following steps: mixing the raw materials in parts by weight, stirring at 65-85 deg.C for 3-5 hr, sterilizing, inspecting, discharging, and packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010110218.8A CN111110620A (en) | 2020-02-23 | 2020-02-23 | Anti-aging, freckle-removing and anti-wrinkle cosmetic |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010110218.8A CN111110620A (en) | 2020-02-23 | 2020-02-23 | Anti-aging, freckle-removing and anti-wrinkle cosmetic |
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| CN111110620A true CN111110620A (en) | 2020-05-08 |
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| CN202010110218.8A Withdrawn CN111110620A (en) | 2020-02-23 | 2020-02-23 | Anti-aging, freckle-removing and anti-wrinkle cosmetic |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115517992A (en) * | 2022-03-07 | 2022-12-27 | 广州市万千粉丝化妆品有限公司 | Application of nucleotide matrix preparation of Shuangze double-antibody in anti-aging and anti-wrinkle cosmetics |
-
2020
- 2020-02-23 CN CN202010110218.8A patent/CN111110620A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115517992A (en) * | 2022-03-07 | 2022-12-27 | 广州市万千粉丝化妆品有限公司 | Application of nucleotide matrix preparation of Shuangze double-antibody in anti-aging and anti-wrinkle cosmetics |
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