CN113925812B - Functional composition for promoting sleep and skin repair and application of functional composition in cosmetics - Google Patents

Functional composition for promoting sleep and skin repair and application of functional composition in cosmetics Download PDF

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CN113925812B
CN113925812B CN202111342543.8A CN202111342543A CN113925812B CN 113925812 B CN113925812 B CN 113925812B CN 202111342543 A CN202111342543 A CN 202111342543A CN 113925812 B CN113925812 B CN 113925812B
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skin
skin repair
mask
promoting
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CN113925812A (en
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孟丽
谢水林
陈凤鸾
聂舟
潘晓燕
王晓慧
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Guangzhou Rui Sen Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The invention relates to an efficacy composition for promoting sleep and skin repair and application thereof in cosmetics, wherein the efficacy composition for promoting sleep and skin repair comprises theanine, camellia extract and quinoa seed extract. The functional composition has remarkable synergistic effect on improving sleep quality, and good sleep fundamentally restores skin, and has remarkable synergistic effect on improving skin glossiness, skin elasticity and moisture retention.

Description

Functional composition for promoting sleep and skin repair and application of functional composition in cosmetics
Technical Field
The invention belongs to the technical field of cosmetics, and relates to an efficacy composition for promoting sleep and skin repair and application of the efficacy composition in cosmetics.
Background
With the acceleration of the life rhythm and the increase of the working pressure, the night-time working, the long-time facing of computers, excessive eyes, smoking, insufficient sleep, long-time waiting in an air-conditioning room, drinking and the like become life normalcy. Every day, each layer of skin can accumulate a large amount of cytomolecular toxins caused by internal or external factors, which can cause choking of skin cells and influence the toxin removing capability of the skin, thereby generating the trouble of dark complexion, lack of luster, relaxation, black eyes, eye edema, fatigue and the like; the burden of the skin is increased, and the skin aging is accelerated.
At present, a plurality of substances or cosmetics with the effects of moisturizing, whitening, anti-aging and the like are reported, for example, CN110496090A discloses a composition and application thereof in preparing skin care products for repairing night damaged skin. The composition provided by the invention comprises adenosine, a saussurea involucrata bulb extract and sodium hyaluronate. The components are mutually matched and mutually promoted, so that the effects of supplementing water and preserving moisture, recovering skin luster, promoting cell energy synthesis and promoting cell proliferation are realized. The composition can be used for preparing cosmetics to improve skin of people staying up all night.
CN110522700a discloses an anti-glycation whitening cosmetic composition and an anti-glycation whitening cosmetic containing the same, comprising one or more of sunflower seed extract, nicotinamide, acetylglucosamine, paper mulberry bark extract, apple extract, camellia extract, tea extract, sumac extract, madecassoside, ethylhexyl glycerol, and tricholoma matsutake extract; the invention can effectively improve the anti-glycation efficacy, prevent, inhibit or improve the problems of dark yellow skin, uneven skin color and the like caused by glycation and oxidization, and simultaneously can also lighten the skin color, reduce skin wrinkles, improve skin texture and restore skin elasticity.
Good sleep quality is also important for repairing skin, and can fundamentally improve the problems of dark complexion, lack of luster, relaxation, dark circles and the like, but the efficacy composition disclosed in the prior art has no efficacy for promoting sleep and repairing skin.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide an efficacy composition for promoting sleep and skin repair and application thereof in cosmetics.
In order to achieve the aim of the invention, the invention adopts the following technical scheme:
in a first aspect, the present invention provides an efficacy composition for promoting sleep and skin repair comprising theanine, camellia extract and quinoa seed extract.
The efficacy composition has the effects of promoting sleep and skin repair, wherein theanine is the free amino acid with the highest content in tea trees, can obviously promote the release of central brain dopamine, and has the effects of relieving stress and tension, relaxing mind and body, improving cognitive ability, improving sleep quality and the like; the camellia extract has excellent moisturizing and anti-wrinkle effects, has soothing and antioxidant activities, can effectively prevent melanin precipitation, keep skin bright, and maintain skin health and freshness; the quinoa seed extract contains various small molecular substances, can be effectively absorbed through skin and permeated into dermis, provides deep and strong moisturizing capability, improves skin hydration capability, enhances fibroblast activity, promotes collagen secretion, and makes cells rich in elasticity. The three components have obvious synergy in improving sleep quality, the skin is restored fundamentally by good sleep, and meanwhile, the three components also have obvious synergy in increasing skin glossiness, skin elasticity and moisture retention, and the composition can be widely applied to the preparation of functional cosmetics.
Preferably, the efficacy composition for promoting sleep and skin repair comprises 0.1-3 parts of theanine, 0.1-2.5 parts of camellia extract and 0.1-2 parts of quinoa seed extract in parts by weight.
The weight portions are calculated by the actual theanine, camellia extract and quinoa seed extract in the commercial raw materials, and the commercial raw materials can optionally contain any one or a combination of at least two of solvents, filling agents, diluents, stabilizers, pH regulators, antibacterial agents, antioxidants or impurities within the allowable range.
The theanine may be 0.1 part, 0.5 part, 0.8 part, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, 3 parts, etc. by weight.
The camellia extract may be 0.1 part, 0.5 part, 0.8 part, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, etc.
The quinoa seed extract may be 0.1 parts, 0.5 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, etc. by weight.
Any other specific point values within the above numerical ranges may be selected, and will not be described in detail herein.
In a second aspect, the present invention provides the use of an efficacy composition for promoting sleep and skin repair as described in the first aspect in the preparation of a cosmetic.
Preferably, the cosmetic comprises a lotion, an emulsion, a cream, a mask, an essence or a gel.
Preferably, the weight percentage of the functional composition for promoting sleep and skin repair in the cosmetic is 0.1-7.5%, for example 0.1%, 0.5%, 1%, 1.5%, 2%, 3%, 4%, 5%, 6%, 7%, 7.5%, etc., and other specific values within the numerical range are selected, so that no further description is given here.
In a third aspect, the invention provides a sleeping mask with effects of promoting sleep and repairing skin, wherein the sleeping mask comprises the following preparation raw materials in percentage by mass: the functional composition for promoting sleep and skin repair of the first aspect comprises 0.1-7.5% of a thickening agent, 0.1-1% of an emollient, 0.5-2% of an emulsifying agent, 0.5-8% of an antibacterial agent and water.
The thickener may be 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% by mass, etc.
The emollient may be 0.1%, 0.2%, 0.4%, 0.5%, 0.6%, 0.8%, 1% by mass, etc.
The mass percentage of the emulsifier can be 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, 2% and the like.
The mass percentage of the antibacterial agent can be 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, 2% and the like.
Any other specific point values within the above numerical ranges may be selected, and will not be described in detail herein.
Preferably, the thickener comprises any one or a combination of at least two of xanthan gum, cetyl ethyl hexanoate, carbomer, hydroxyethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, hydrolyzed small-core gum, tara gum, carrageenan, acrylic acid (esters) or C10-30 alkanol acrylate cross-linked polymer or sodium hyaluronate.
The combination of at least two of the above-mentioned compounds, such as a combination of xanthan gum and cetyl ethyl hexanoate, a combination of carbomer and hydroxyethyl cellulose, a combination of hydroxypropyl methylcellulose and hydrolyzed sclerotium gum, etc., may be selected, and any other combination will not be described herein.
Preferably, the thickener comprises a combination of hydroxyethyl cellulose and hydrolyzed ringworm gum.
The combination of the thickening agent, preferably hydroxyethyl cellulose, and the hydrolyzed sclerotium rolfsii in the sleeping mask can ensure that the stability of the system is better, and layering and precipitation phenomena do not occur in high-temperature and low-temperature environments.
Preferably, the emollient comprises any one or a combination of at least two of glyceryl caprylate, squalane, olive fruit oil, white pool seed oil, jojoba esters, shea fruit oil, sweet almond oil, grape seed oil, caprylic/capric triglyceride, hydrogenated coco glyceride, phytosterol isostearate, isononyl isononanoate, or arachidyl alcohol.
The combination of at least two of these components, such as the combination of glyceryl caprylate and squalane, the combination of olive fruit oil and white pool flower seed oil, the combination of butter fruit oil and sweet almond oil, etc., may be selected in any other combination manner, and will not be described in detail herein.
Preferably, the emollient comprises a combination of squalane, caprylic/capric triglyceride and olive oil.
The combination of the squalane, the caprylic/capric triglyceride and the olive oil in the sleep mask is preferable to be capable of further synergistically promoting the exertion of the effect composition on the skin restoration effect.
Preferably, the emulsifier comprises any one or a combination of at least two of glycerol stearate, cetostearyl alcohol, sodium stearoyl lactylate, glycerol stearate citrate, cholesterol, cetostearyl alcohol oleyl oleate, sorbitan stearate, polyglycerol-10 oleate or polysorbate-60.
The combination of at least two of these compounds, such as a combination of glyceryl stearate and cetostearyl alcohol, a combination of glyceryl stearate citrate and cholesterol, a combination of sorbitan olive oleate and sorbitan stearate, etc., may be selected, and any other combination will not be described in detail herein.
Preferably, the emulsifier comprises a combination of glycerol stearate, cetyl stearyl alcohol and sodium stearoyl lactylate.
The combination of the emulsifier, preferably glycerol stearate, cetyl stearyl alcohol and sodium stearoyl lactylate in the sleeping mask can ensure that the stability of the system is better, and layering and precipitation phenomena do not occur in high-temperature and low-temperature environments.
Preferably, the antimicrobial agent comprises any one or a combination of at least two of 1, 3-propanediol, octanoyl glycol, ethylhexyl glycerol, octanoyl hydroxamic acid, or 1, 2-hexanediol.
The combination of at least two of the above-mentioned compounds, such as a combination of 1, 3-propanediol and octanoyl glycol, a combination of ethylhexyl glycerol and octanoyl hydroxamic acid, a combination of octanoyl hydroxamic acid and 1, 2-hexanediol, etc., may be selected, and any other combination manner will not be described herein.
In a fourth aspect, the present invention provides a method for preparing a sleep mask having effects of promoting sleep and skin repair according to the third aspect, the method comprising:
(1) Heating water, mixing with thickener, emulsifier and emollient, homogenizing to obtain a first mixture;
(2) And mixing and stirring the first mixture, the functional composition for promoting sleep and skin repair and the antibacterial agent to obtain the sleep mask with the effects of promoting sleep and skin repair.
Preferably, the heating means heating to 80-90 ℃, such as 80 ℃, 82 ℃, 85 ℃, 88 ℃, 90 ℃, etc., and any other point value within the numerical range can be selected, and will not be described in detail herein.
Preferably, the homogenizing is carried out at a temperature of 70-80deg.C (e.g., 70deg.C, 72deg.C, 75deg.C, 78deg.C, 80deg.C, etc.) and a rotational speed of 1000-3000rpm (e.g., 1000rpm, 1500rpm, 2000rpm, 2500rpm, 3000rpm, etc.) for 2-8min (e.g., 2min, 3min, 4min, 5min, 6min, 8min, etc.); any other point value within the above numerical range may be selected, and will not be described in detail herein.
Preferably, the mixing and stirring is carried out at a rotational speed of 500-1000rpm (e.g., 500rpm, 600rpm, 700rpm, 800rpm, 1000rpm, etc.) at 35-45 ℃ (e.g., 35 ℃, 38 ℃, 40 ℃, 42 ℃, 45 ℃, etc.) for 10-20min (e.g., 10min, 12min, 15min, 16min, 18min, 20min, etc.); any other point value within the above numerical range may be selected, and will not be described in detail herein.
Compared with the prior art, the invention has the following beneficial effects:
the efficacy composition has the effects of promoting sleep and skin repair, wherein theanine is the free amino acid with the highest content in tea trees, can obviously promote the release of central brain dopamine, and has the effects of relieving stress and tension, relaxing mind and body, improving cognitive ability, improving sleep quality and the like; the camellia extract has excellent moisturizing and anti-wrinkle effects, has soothing and antioxidant activities, can effectively prevent melanin precipitation, keep skin bright, and maintain skin health and freshness; the quinoa seed extract contains various small molecular substances, can be effectively absorbed through skin and permeated into dermis, provides deep and strong moisturizing capability, improves skin hydration capability, enhances fibroblast activity, promotes collagen secretion, and makes cells rich in elasticity. The three components have obvious synergy in improving sleep quality, the skin is restored fundamentally by good sleep, and meanwhile, the three components also have obvious synergy in increasing skin glossiness, skin elasticity and moisture retention, and the composition can be widely applied to the preparation of functional cosmetics.
Detailed Description
In order to further describe the technical means adopted by the present invention and the effects thereof, the following describes the technical scheme of the present invention in combination with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.
The Theanine referred to in the following examples, comparative examples, application examples, comparative application examples was derived from the Theanine product of model L-Theanine available from Vickers corporation; the camellia extract is obtained from a camellia extract product of model CAMELLIA JAPONICA FLOWER EXTRACT purchased from the Bai-bo company; the quinoa seed extract referred to is derived from the quinoa seed extract product available from the seebec company under the model adinoless.
Hydroxyethyl cellulose was purchased from Huilan under the model Natrosol 250HHR; the hydrolyzed sclerotium rolfsii is purchased from Yu Quanxing, and the model is hydrolyzed sclerotium rolfsii; caprylic/capric triglyceride was purchased from New Ann, model number318RC; the olive oil is obtained from Cheng Ji Ya and is pure olive oil.
Example 1
The embodiment provides an efficacy composition for promoting sleep and skin repair, which comprises the following active ingredients in parts by weight: 2 parts of theanine, 1 part of camellia extract and 1.5 parts of quinoa seed extract.
Example 2
The embodiment provides an efficacy composition for promoting sleep and skin repair, which comprises the following active ingredients in parts by weight: 3 parts of theanine, 2.5 parts of camellia extract and 2 parts of quinoa seed extract.
Example 3
The embodiment provides an efficacy composition for promoting sleep and skin repair, which comprises the following active ingredients in parts by weight: 1 part of theanine, 1 part of camellia extract and 1 part of quinoa seed extract.
Comparative example 1
The comparative example provides an efficacy composition which comprises the following active ingredients in parts by weight: 1 part of camellia extract and 1.5 parts of quinoa seed extract.
Comparative example 2
The comparative example provides an efficacy composition which comprises the following active ingredients in parts by weight: 2 parts of theanine and 1.5 parts of quinoa seed extract.
Comparative example 3
The comparative example provides an efficacy composition which comprises the following active ingredients in parts by weight: 2 parts of theanine and 1 part of camellia extract.
Comparative example 4
This comparative example provides an efficacy substance comprising the single active ingredient theanine.
Comparative example 5
The present comparative example provides an effective substance comprising a single active ingredient camellia extract.
Comparative example 6
This comparative example provides an efficacy substance comprising a single active ingredient quinoa seed extract.
Application example 1
The application example provides a sleeping mask for promoting sleep and skin repair, which comprises the following preparation raw materials, by mass, 1.5% of the efficacy composition of the example 1, 0.2% of hydroxyethyl cellulose, 0.3% of hydrolyzed sclerotium rolfsii, 0.2% of squalane, 0.8% of caprylic/capric triglyceride, 0.3% of olive oil, 1.5% of glycerol stearate, 2% of cetostearyl alcohol, 3.5% of sodium stearoyl lactylate, 2.5% of 1, 3-propylene glycol, 2% of octanoyl hydroxamate, 1.5% of 1, 2-hexanediol and the balance of water. The preparation method comprises the following steps:
(1) Heating water to 85deg.C, mixing with hydroxyethyl cellulose, hydrolyzed sclerotium gum, squalane, caprylic/capric triglyceride, olive oil, glycerol stearate, cetostearyl alcohol, and sodium stearoyl lactylate, homogenizing at 75deg.C at 2500rpm for 5min to obtain a first mixture;
(2) The first mixture was mixed with the functional composition of example 1 and 1, 3-propanediol, octanoyl hydroxamic acid, 1, 2-hexanediol at 40 ℃ and a rotational speed of 700rpm for 15min to obtain the sleeping mask having the effects of promoting sleep and skin restoration.
Application example 2
The application example provides a sleeping mask for promoting sleep and skin repair, which comprises the following preparation raw materials, by mass, 1.5% of the efficacy composition of the example 2, 0.2% of hydroxyethyl cellulose, 0.3% of hydrolyzed sclerotium rolfsii, 0.2% of squalane, 0.8% of caprylic/capric triglyceride, 0.3% of olive oil, 1.5% of glycerol stearate, 2% of cetostearyl alcohol, 3.5% of sodium stearoyl lactylate, 2.5% of 1, 3-propylene glycol, 2% of octanoyl hydroxamate, 1.5% of 1, 2-hexanediol and the balance of water. The preparation method comprises the following steps:
(1) Heating water to 80deg.C, mixing with hydroxyethyl cellulose, hydrolyzed sclerotium gum, squalane, caprylic/capric triglyceride, olive oil, glycerol stearate, cetostearyl alcohol, and sodium stearoyl lactylate, homogenizing at 70deg.C for 4min at 3000rpm to obtain a first mixture;
(2) The first mixture was mixed with the functional composition of example 1 and 1, 3-propanediol, octanoyl hydroxamic acid, 1, 2-hexanediol at 35 c and a rotational speed of 1000rpm for 10min to obtain the sleeping mask having the effects of promoting sleep and skin restoration.
Application example 3
The application example provides a sleeping mask for promoting sleep and skin repair, which comprises the following preparation raw materials, by mass, 1.5% of the efficacy composition of example 3, 0.2% of hydroxyethyl cellulose, 0.3% of hydrolyzed sclerotium rolfsii, 0.2% of squalane, 0.8% of caprylic/capric triglyceride, 0.3% of olive oil, 1.5% of glycerol stearate, 2% of cetostearyl alcohol, 3.5% of sodium stearoyl lactylate, 2.5% of 1, 3-propylene glycol, 2% of octanoyl hydroxamate, 1.5% of 1, 2-hexanediol and the balance of water. The preparation method comprises the following steps:
(1) Heating water to 90deg.C, mixing with hydroxyethyl cellulose, hydrolyzed sclerotium gum, squalane, caprylic/capric triglyceride, olive oil, glycerol stearate, cetostearyl alcohol, and sodium stearoyl lactylate, homogenizing at 80deg.C at 2000rpm for 8min to obtain a first mixture;
(2) The first mixture was mixed with the functional composition of example 1 and 1, 3-propanediol, octanoyl hydroxamic acid, 1, 2-hexanediol at 45 c for 20min at 600rpm to obtain the sleeping mask having the effects of promoting sleep and skin restoration.
Comparative application examples 1 to 6
The present comparative example provides six sleep masks whose raw materials for preparation differ from application example 1 only in that the efficacy composition of example 1 is replaced with the equivalent efficacy compositions of comparative examples 1-6, with the other raw materials and amounts remaining unchanged. The preparation method is described in application example 1.
Application example 4
The application example provides a sleeping mask for promoting sleep and skin repair, and the preparation raw materials of the sleeping mask are different from application example 1 only in that 0.2% of squalane, 0.8% of caprylic/capric triglyceride and 0.3% of olive fruit oil serving as raw materials are replaced by caprylic/capric triglyceride and olive fruit oil serving as raw materials (the total content is 1.3% and the mass ratio is 8:3). The other raw materials and the content are kept unchanged. The preparation method is described in application example 1.
Application example 5
The application example provides a sleeping mask for promoting sleep and skin repair, and the preparation raw materials of the sleeping mask are different from application example 1 only in that 0.2% of squalane, 0.8% of caprylic/capric triglyceride and 0.3% of olive fruit oil are replaced by squalane and olive fruit oil (the total content is 1.3% and the mass ratio is 2:3). The other raw materials and the content are kept unchanged. The preparation method is described in application example 1.
Application example 6
The application example provides a sleeping mask for promoting sleep and skin repair, and the preparation raw materials of the sleeping mask are different from application example 1 only in that 0.2% of squalane, 0.8% of caprylic/capric triglyceride and 0.3% of olive fruit oil are replaced by squalane and caprylic/capric triglyceride (the total content is 1.3% and the mass ratio is 1:4). The other raw materials and the content are kept unchanged. The preparation method is described in application example 1.
Application example 7
The application example provides a sleeping mask for promoting sleep and skin repair, and the preparation raw materials of the sleeping mask are different from application example 1 only in that 0.2% of squalane, 0.8% of caprylic/capric triglyceride and 0.3% of olive fruit oil are replaced by the raw materials of squalane (the total content is 1.3%). The other raw materials and the content are kept unchanged. The preparation method is described in application example 1.
Application example 8
The application example provides a sleeping mask for promoting sleep and skin repair, and the preparation raw materials of the sleeping mask are different from application example 1 only in that 0.2% of squalane, 0.8% of caprylic/capric triglyceride and 0.3% of olive fruit oil are replaced by caprylic/capric triglyceride (the total content is 1.3%). The other raw materials and the content are kept unchanged. The preparation method is described in application example 1.
Application example 9
The application example provides a sleeping mask for promoting sleep and skin repair, and the preparation raw materials of the sleeping mask are different from application example 1 only in that 0.2% of squalane, 0.8% of caprylic/capric triglyceride and 0.3% of olive oil are replaced by the raw material of olive oil (the total content is 1.3%). The other raw materials and the content are kept unchanged. The preparation method is described in application example 1.
Application example 10
The application example provides a sleeping mask for promoting sleep and skin repair, and the preparation raw materials are different from application example 1 only in that 0.2% of raw material hydroxyethyl cellulose and 0.3% of hydrolyzed sclerotium gum are replaced by 0.5% of hydroxyethyl cellulose, and other raw materials and contents are kept unchanged. The preparation method is described in application example 1.
Application example 11
The application example provides a sleeping mask for promoting sleep and skin repair, and the preparation raw materials are different from application example 1 only in that 0.2% of hydroxyethyl cellulose and 0.3% of hydrolyzed sclerotium rolfsii are replaced by 0.5% of hydrolyzed sclerotium rolfsii, and other raw materials and contents are kept unchanged. The preparation method is described in application example 1.
Test example 1
And (3) testing the moisturizing effect:
test instrument: multifunctional skin tester, model Corneometer CM825MDD, germany CK company.
The test principle is as follows: the principle of the capacitance method is that the capacitance value of the skin is different according to the different water contents of the skin, and the observation parameter can represent the skin moisture value.
Test environment: the test environment temperature is 22+/-1 ℃, the humidity is 50+/-5%, and the real-time dynamic detection is carried out.
Test object: active volunteers 170 (randomized into 17 groups of 10 persons each) aged between 25-35 years (except pregnant or lactating women); the basis value of the measurement significance of the forearm test area capacitance method skin moisture is 15-100; patients with no serious systemic disease, no immunodeficiency or autoimmune disease; the prior skin care cosmetics have no serious allergic history; hormonal drugs and immunosuppressants have not been used for a month; those who did not participate in other clinical trials; the tested medicines are used according to the regulations and the data are complete; all volunteers should fill in informed consent prior to testing.
The testing steps are as follows:
preparation before testing: no product (cosmetic or topical medicine) can be used 3 days before the test site. Prior to the experiment, the subjects were required to agree to clean the forearm inner test of both hands and air dry. After cleaning, the measurement area marks are measured in the forearms of both hands of the subject. Before formal test, the patient should sit still in a room meeting the standard for at least 30min, cannot drink water, and the forearm is exposed and placed in a test state to be relaxed.
The testing process comprises the following steps: marking the inner sides of the left arm and the right arm of each person by 2X 2cm 2 The test areas, 3 areas are marked on the same arm, the areas are spaced 1cm apart, and the test areas are used for testing each group of samples respectively. Skin moisture content measurements were made in the test and control areas using probe Corneometer CM 825. Each zone was measured 3 times in parallel. First, the blank value M of each test area is measured 0 Then at a rate of 2mg sample/cm 2 The test sample is applied to the same area of the test subject by itself once a day according to the test method, and the moisture content M of the skin is tested on days 14 and 28 without applying the sample to be tested 1 Testing of the same volunteer was done by the same measurer.
Test data: the skin moisture content of each time period was measured separately according to the experimental design, and the increase in skin moisture content of each time period was calculated according to the following formula.
The results are shown in Table 1:
TABLE 1
As can be seen from the data in table 1: the sleeping mask for promoting sleep and skin repair can obviously repair the barrier function of skin and promote the moisture content of the skin. Compared with comparative application examples 1-6, the sleeping mask for promoting sleep and skin repair has better moisturizing effect under the synergistic cooperation of the functional composition, and the camellia extract plays a main role in moisturizing. Meanwhile, the combination mode of the skin-moistening agent also has important influence on the moisturizing effect of the facial mask.
Test example 2
Skin elasticity test:
the testing method comprises the following steps: 85 volunteers with 30-45 years old and healthy skin and without damage are selected, and randomly divided into 17 groups, wherein 5 volunteers are used for 3 times per week after the subjects wash the face every night, and the facial masks prepared in application examples 1-11 and comparative application examples 1-6 are respectively used for 4 weeks continuously. During the experiment, the subject was unable to apply any other cosmetics at the experimental site.
Data acquisition is carried out by using a skin elastometer Cutometer MPA580 respectively at the time of non-use, the time of week 0 and the time of week 4, the test part is the cheekbone part, and the probe repeatedly measures 3 times in the same measured area during measurement, and the average value is obtained. The test parameter is R2 (ratio of the rebound amount Ua of the skin without negative pressure to the maximum stretching amount Uf with negative pressure), and the closer R2 is to 1, the better the skin elasticity is. The test results are shown in Table 2. Average change value of R2 = 4 th week R2 value-0 th week R2 value, average change rate of R2 = average change value of R2/0 th week R2 value.
TABLE 2
As can be seen from the data in table 2: the sleeping mask for promoting sleep and skin repair can obviously repair the barrier function of skin and promote the elasticity of the skin. Compared with comparative application examples 1-6, the sleeping mask for promoting sleep and skin repair provided by the invention has a synergistic effect on improving skin elasticity under the synergistic cooperation of theanine, camellia extract and quinoa seed extract. At the same time, the combination of emollients also has an important effect on this effect of the mask.
Test example 3
Skin gloss test:
the testing process comprises the following steps: the skin gloss of the test area was measured using probe GL200 using the same volunteers as in test example 1 as test subjects. Each zone was assayed 15 times in parallel. The blank value of each test area was measured and recorded as G0, and then measured as 2mg sample/cm 2 The sample is uniformly smeared in a test area, and the sample is completely absorbed. The test sample is smeared on the same area by the test method for one time per day, and the glossiness Gn of the skin of the corresponding area is tested under the condition that the sample to be tested is not smeared on days 14 and 28.
Test data: the skin glossiness at each time point was measured separately according to the experimental design, and the increase in skin glossiness at each time point was calculated according to the following formula.
Increase in skin gloss (%) = (Gn-G0)/g0×100%
The results are shown in Table 3:
TABLE 3 Table 3
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As can be seen from the data in table 3: the sleeping mask for promoting sleep and skin repair can obviously repair the barrier function of skin and improve the glossiness of the skin. Compared with comparative application examples 1-6, the sleeping mask for promoting sleep and skin repair has a synergistic effect on improving skin glossiness under the synergistic cooperation of theanine, camellia extract and quinoa seed extract. At the same time, the combination of emollients also has an important effect on this effect of the mask.
Test example 4
Evaluation of sleep promoting effect:
the pittsburgh sleep quality index scoring table (PSQI) is composed of 19 self-scoring entries and 5 critique entries, wherein the 19 th self-scoring entry and 5 critique entries do not participate in scoring. The 18 self-assessed entries were combined into 7 components including subjective sleep quality, time to sleep, sleep efficiency, sleep disorders, hypnotic use, daytime dysfunction. Each component was scored on a scale of 0 to 3, and the score of each component was accumulated as a total score of PSQI, and the score was 21 points full, with a higher score indicating a poorer sleep quality.
The test mainly uses the total score of the scale to reflect the influence of the sleep mask of the invention on the sleep quality. The using method and the frequency are as follows:
randomly selecting 85 office workers with PSQI self-test table scores of 11-15 as study objects by adopting a questionnaire investigation mode, randomly dividing the study objects into application examples 1-11 groups, comparing the application examples 1-6 groups, and carrying out study on 5 cases of each group, wherein the age is 25-35 years; and 15 minutes before sleeping every night, uniformly smearing the same amount of sleeping mask on the face, and closing electronic equipment such as a mobile phone and the like.
Each group of testers was investigated with a pittsburgh sleep quality index (Pittsburgh Sleep Quality Index, PSQI) self-test table and data statistics were summarized after 30 days of continuous use. The statistical results are shown in Table 4.
TABLE 4 Table 4
Remarks: scoring grade: 0-5 minutes, and the sleeping quality is good; 6-10 minutes, the sleep quality is improved; 11-15 minutes, and the sleeping quality is general; 16-21 minutes, the sleeping quality is poor.
As can be seen from the data in table 4: the sleeping mask for promoting sleep and skin repair can effectively improve sleep quality, so that skin problems are fundamentally repaired. Compared with comparative application examples 1-6, the sleeping mask for promoting sleep and skin repair provided by the invention has a synergistic effect on promoting sleep quality under the synergistic cooperation of theanine, camellia extract and quinoa seed extract.
Test example 5
System stability test:
after the sleeping mask of application examples 1-11 was left to stand in a high temperature environment (45 ℃) and a low temperature environment (4 ℃) for 6 months, whether layering and caking phenomenon occurred or not was observed, and the results show that the products of application examples 1-9 did not occur in the high temperature environment (45 ℃) and the low temperature environment (4 ℃) for 6 months, and the products of application examples 10-11 had a small amount of layering or caking phenomenon.
The applicant states that the present invention is illustrated by the above examples as an effective composition for promoting sleep and skin repair and its use in cosmetics, but the present invention is not limited to the above examples, i.e. it does not mean that the present invention must be practiced depending on the above examples. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of raw materials for the product of the present invention, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present invention and the scope of disclosure.
The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solution of the present invention within the scope of the technical concept of the present invention, and all the simple modifications belong to the protection scope of the present invention.
In addition, the specific features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations are not described further.

Claims (16)

1. The functional composition for promoting sleep and skin repair is characterized by comprising, by weight, 0.1-3 parts of theanine, 0.1-2.5 parts of camellia extract and 0.1-2 parts of quinoa seed extract.
2. Use of the sleep and skin repair promoting composition according to claim 1 in the preparation of cosmetics.
3. The use according to claim 2, wherein the cosmetic comprises a lotion, an emulsion, a cream, a mask, an essence or a gel.
4. The use according to claim 2, wherein the functional composition for promoting sleep and skin repair is contained in an amount of 0.1 to 7.5% by mass in the cosmetic.
5. The sleeping mask with the effects of promoting sleep and repairing skin is characterized by comprising the following preparation raw materials in percentage by mass: the composition for promoting sleep and skin repair according to claim 1, wherein the composition comprises 0.1-7.5% of the skin repair agent, 0.1-1% of the thickener, 0.5-2% of the emollient, 0.5-8% of the emulsifier, 0.5-8% of the antibacterial agent, and water.
6. The sleep mask having the effect of promoting sleep and skin repair according to claim 5, wherein the thickener comprises any one or a combination of at least two of xanthan gum, cetyl ethyl hexanoate, carbomer, hydroxyethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, hydrolyzed sclerotium gum, tara gum, carrageenan, acrylic acid (esters) ester/C10-30 alkanol acrylate cross-linked polymer or sodium hyaluronate.
7. The sleep mask having the effect of promoting sleep and skin repair according to claim 6, wherein the thickener comprises a combination of hydroxyethyl cellulose and hydrolyzed small nuclear fungus gel.
8. The sleep mask having sleep and skin restoration effects according to claim 5, wherein said emollient comprises any one or a combination of at least two of glyceryl caprylate, squalane, olive oil, white pool seed oil, jojoba esters, shea butter, sweet almond oil, grape seed oil, caprylic/capric triglyceride, hydrogenated coco glyceride, phytosterol isostearate, isononyl isononanoate, or arachidyl alcohol.
9. The sleep mask having the effect of promoting sleep and skin repair according to claim 8, wherein the emollient comprises a combination of squalane, caprylic/capric triglyceride and olive oil.
10. The sleep mask having the effect of promoting sleep and skin repair according to claim 5, wherein the emulsifier comprises any one or a combination of at least two of glycerol stearate, cetostearyl alcohol, sodium stearoyl lactylate, glycerol stearate citrate, cholesterol, cetostearyl alcohol oleyl ester, sorbitan stearate, polyglycerin-10 oleyl ester, or polysorbate-60.
11. The sleep mask having the effect of promoting sleep and skin repair according to claim 10, wherein the emulsifier comprises a combination of glycerol stearate, cetyl stearyl alcohol and sodium stearoyl lactylate.
12. The sleep mask having the effect of promoting sleep and skin repair according to claim 5, wherein the antibacterial agent comprises any one or a combination of at least two of 1, 3-propanediol, octanediol, ethylhexyl glycerol, octanoyl hydroxamic acid, or 1, 2-hexanediol.
13. The method for preparing a sleep mask having effects of promoting sleep and skin repair according to any one of claims 5 to 12, comprising:
(1) Heating water, mixing with thickener, emulsifier and emollient, homogenizing to obtain a first mixture;
(2) And mixing and stirring the first mixture, the functional composition for promoting sleep and skin repair and the antibacterial agent to obtain the sleep mask with the effects of promoting sleep and skin repair.
14. The method for preparing a sleeping mask having the effects of promoting sleep and skin repair according to claim 13, wherein the heating means heating to 80-90 ℃.
15. The method for preparing a sleeping mask having the effects of promoting sleep and skin repair according to claim 13, wherein the homogenization is performed at a rotation speed of 1000-3000rpm for 2-8min at 70-80 ℃.
16. The method for preparing a sleeping mask having the effects of promoting sleep and skin repair as claimed in claim 13, wherein the mixing and stirring are performed at 35-45 ℃ for 10-20min at 500-1000 rpm.
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CN114712277B (en) * 2022-02-21 2023-07-07 广州睿森生物科技有限公司 Moisturizing and repairing composition, cosmetic and preparation method
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