CN107496245A - A kind of anti-aging liposome composition and its preparation method and application - Google Patents
A kind of anti-aging liposome composition and its preparation method and application Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The present invention relates to household chemicals field, discloses a kind of anti-aging liposome composition, including following weight percent composition：5 10% grape fruit peel oil；0.1 5% Atlas cedar bark oil：0.2 1% goosefoot seed extract；20 50% Surfhope SE Cosme C 1216；The 1 of 9 15%, 3 propane diols；0.1 0.5% NAP；3 5% soybean lecithin；Deionized water complements to 100%.Said composition passes through the synergy between each composition, the effectively hydratability of lifting skin, strengthen skin barrier function, lift skin elasticity, so as to effectively delaying skin aging, unique liposome technology, the absorption of active material is increased, the addition of active matter is reduced, reduces product and side effect and cost.
Description
Technical field
The present invention relates to household chemicals field, and in particular to a kind of anti-aging liposome composition and preparation method thereof, and be related to
Cosmetics containing said composition.
Background technology
Skin senescence forms wrinkle, makes the skin of original plump gloss become uneven, and skin diopter is deteriorated, and loses
Gloss in the past.Ageing skin water content is reduced, and pigment then accordingly increases, and the pigmentations such as chloasma and senile plaque expelling occurs.Wrinkle
The appearance of the clinical symptoms such as line, senile plaque expelling, after the generation of aging phenomenon, life, work to people have the heart of complexity
Reason and physiological effect, it such as may trigger anxiety, depression, feel oneself inferior at a series of psychological problems.Anti-aging product cosmetics are always
As the temperature of in the market, it is desirable to improve quality of life by anti-aging.
And aging is one of most basic natural law of living nature, the aging of skin is divided into exogenous aging and exogenous
Aging, exogenous aging is mainly because of environmental factor, such as ultraviolet radiation, smoking, wind, Exposure to Sunlight and contact harmful chemical
Cause.The radiation of daylight middle-ultraviolet lamp is extrinsic aging principal element.But skin also holds under the erosion of external environment for a long time
Easily there is aging.The skin of aging occur it is rough show slightly plump, sulci of skin is deepened, cutaneous ridge protuberance, leather sample outward appearance, i.e. institute occurs
Call thick deep wrinkle, such as cutis rhomboidalis nuchae.Chronic sun exposure can cause skin keratin to thicken, or the barrier function of thing cuticula
Imbalance.Skin microcirculation can also change, and such as telangiectasis or disappearance, skin appearance is gloomy, matt or in ash
Yellow.
The mechanism of aging is extremely complex, and more representational causes of senescence mainly includes:Cell mutation theory, DNA damages
Hinder theory, injury of mitochondria theory, tolemerase, free radical theory, non-glycosylation theory, immunologic function changes theory, god
Through endocrine causes of senescence.Cell mutation theory thinks that frequency dividing cell is directly proportional to the life-span, and aging is due to cell damage
And mutation is produced, so that the cell after cell itself and its division is abnormal, physiological function declines, and division number reduces.And
Free radical theory is thought, under the conditions of normal triumph, resulting from for machine interior free yl is in dynamic equilibrium with eliminating, once this
Kind balance is damaged, and causes excessive free radical to produce, excessive free radical can be to chromosome, mitochondria, cell membrane and connective
The murder by poisoning sexual assault of the biological tissues such as tissue causes the aging of body.
It is in close relations between the decrease and dry skin of epidermal barrier function.Moisture in cuticula is 10-15%,
The relative constancy of water depends on NMF：Amino acid, 2-pyrrolidone-5-carboxylic acid, lactate, urea, uric acid, creatine, phosphoric acid
Salt etc., with advancing age, the NMF content in cuticula are reduced, and cause the hydratability of skin to decline, only
For the 75% of normal skin.If stratum corneum barrier function receives damage, scattering and disappearing for moisture of skin will be accelerated, can also accelerate skin
Aging.Stable keratoderma barrier function is to maintain the key of skin health, when stratum corneum barrier function is stable, skin
Skin will show good health status, so as to the aging of delaying skin.
At present, the main anti-aging product of in the market is mainly for three aspects：1st, the free radical on skin is removed；2nd, lead to
Cross and add some NMFs or nutriment from outside to supplement the moisture of skin losses and protein ingredient；3rd, promote cell newly old
Metabolism.Percutaneous absorbtion approach cuticula, hair follicle and the sweat gland of cosmetics, but rear two paths only account for the 1% of whole skin surface with
Under, but most nutriment is difficult to by the cuticula rich in lipoid.The most product of in the market is intended to by adding
Add substantial amounts of nutriment or NMF to reach product effect, but these nutriments can not often be inhaled by skin completely
Receive utilize, bioavailability is low, it is with high costs simultaneously, fail to reach product expected effect.
Liposome possesses the hydrophilic and oleophilic structure of uniqueness, and liposome with cutin-softening, can make the material of encapsulating reach effect
Position, and one layer of protective film, skin-moisturizing, skin can be formed in skin surface.The A of Chinese patent CN 106539711 disclose one kind
New skin cream and preparation method, moist, anti-aging effects are provided by NMFs such as sea-buckthorn oil lipidosome, glycerine, hyaluronic acids,
But anti-aging effects only are provided by Seabuckthorn Oil, effect is not notable.The A of Chinese patent CN 104490677 disclose a kind of lipid
Body essence lotion, by the bioactive ingredients such as Porcine HGF, the NMF such as Herba Saussureae Involueratae extract, hyaluronic acid, glycerine
It is higher Deng the liposome of composition, bioavailability, excellent effect, but it is with high costs.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of anti-aging liposome composition and preparation method, the combination
Thing effectively lifts the hydratability of skin, strengthens skin barrier function, lift skin bullet by the synergy between each composition
Property, so that effectively delaying skin aging, unique liposome technology, increases the absorption of active material, reduce active matter
Addition, reduce product and side effect and cost.
The technical problems to be solved by the invention are achieved by the following technical programs：
A kind of anti-aging liposome composition, including following weight percent composition：
5-10% grape fruit peel oil；
0.1-5% Atlas cedar bark oil：
0.2-1% goosefoot seed extract；
20-50% Surfhope SE Cosme C 1216；
9-15% 1,3-PD；
0.1-0.5% NAP；
3-5% soybean lecithin；
Deionized water complements to 100%.
Further, preferably following weight percent composition：
6-8% grape fruit peel oil.
0.5-3.5% Atlas cedars bark oil.
0.2-0.8% goosefoot seed extract；
Further, preferably following weight percent composition：25-35% Surfhope SE Cosme C 1216.
Further, preferably following weight percent composition：7.5-13.5% 1,3-PD.
Further, preferably following weight percent composition：0.35-0.45% NAP.
Further, preferably following weight percent composition：2.5-4.5% soybean lecithin.
A kind of preparation method of described grape fruit peel oil, comprises the following steps：
A. by the pericarp of grapefruit it is dry, smash to pieces, cross 50-200 mesh sieves；
B. the grape fruit pericarp that a is obtained is immersed in ethanol solution, 20-30min is smashed in ultrasonic cell disruptor, will
The liquid revolving arrived, which is dried, removes ethanol；
C. the grape fruit pericarp powder obtained in b is put into progress carbon dioxide supercritical extraction in extraction kettle and obtains grape fruit pericarp
Oil, control parameter are：Pressure 20MPa-35MPa, temperature are 25-60 DEG C, extraction time 60-120min, the stream of carbon dioxide
Measure as 10L/min-20L/min.
A kind of preparation method of described anti-aging liposome composition, comprises the following steps：
（1）Described NAP is dissolved in citrate buffer solution, the concentration of citrate buffer solution
For 0.08mol/L, the amount of citrate buffer solution used causes the pH value of solution system to be adjusted to 6-7.5, obtains aqueous phase
Solution；
（2）Grape fruit peel oil, Atlas cedar bark oil, the mixing of goosefoot seed extract, Surfhope SE Cosme C 1216,50-65 DEG C
Lower heating stirring, mixing speed 80-200rpm, 30min is stirred, obtains oil-phase solution；
（3）By soybean lecithin and 1,3-PD according to 1：3 is well mixed, supplies excess water；
（4）Under conditions of stirring, by aqueous phase solution and oil-phase solution side homogeneous, while be added to soybean lecithin and 1,3- the third two
In alcoholic solution, in 30-60 degrees Celsius of lower homogeneous 10-20min, be ultrasonically treated 5~10min, cross miillpore filter obtain liposome into
Product.
A kind of described stop type of anti-aging liposome composition or the cosmetics of wash type containing arbitrary proportion.
Further, the formulation of the cosmetics is any one in white shape, emulsus, watery, Gel miles of shape
After applying above-mentioned technical scheme, the present invention has the advantages that：
1st, a kind of active component of anti-aging liposome composition provided by the invention includes grape fruit peel oil, goosefoot seed
Extract, deodar bark oil, NAP.Wherein grape fruit peel oil has extensive bioactivity, containing rich
Rich flavonoids, has many pharmacological actions in humans and animals body, because the hydrogen atom on its phenolic hydroxyl group can be with peroxide certainly
By base junction symphysis into flavones free radical, so with other radical reactions, so as to terminate free chain reaction, flavonoids has
Excellent removing free radical, antiallergy, antiviral, anti-inflammatory, reduce the abilities such as capillary fragility, can be purified with deep layer dark sore and
Substantial, consolidation skin etc. and other effects, can strengthen cells against free radicals ability, so as to improve skin barrier function.Faced by super
Boundary's carbon dioxide abstraction grape fruit peel oil can effectively improve the content of flavonoids in grape fruit peel oil.
2nd, protein content is up to 16%-22% in high-quality goosefoot seed, rich in several amino acids, wherein there is human body must
The all 9 kinds of essential amino acids needed, are especially enriched in the lysine lacked in plant, calcium, magnesium, phosphorus, potassium, iron, zinc, selenium, manganese, copper etc.
Mineral matter nutritional content is high, rich in unrighted acid, flavonoids, B family vitamin and E family vitamins, choline, glycine betaine, leaf
The multiple beneficial compound such as acid, alpha-linolenic acid, beta glucan, contain a variety of small-molecule substances in goosefoot seed extract, can
Effectively percutaneous absorbtion, penetrate into skin corium, there is provided the potent moisture-retaining capacity of deep layer, lift skin hydration ability, strengthen into
Fibrocyte activity, promotes the secretion of collagen, makes cell high resilience.
3rd, deodar is the general term of Pinaceae Cedrus seeds, in medicine with spasmolysis and analgesia anti-inflammatory, anticancer, antibacterial, disease-resistant
A variety of pharmacological activity such as poison, containing abundant OPC it is a kind of biological species for having special molecular structure in deodar bark oil
Flavones, it is the maximally effective natural of removing people's interior free yl generally acknowledged in the world at present, there is significant anti-freedom
Base, resistance UV effects, oxidation resistance.
4th, NAP has stronger reproducibility, melanin intermediates can be played with reduction, reduction is
Melanin through formation, established melanin deposition is reduced, blackspot, freckle can be reduced simultaneously, collage synthesis process is entered
Row activation, the formation to lipid peroxide are disturbed, can effectively improve skin aging, make skin consolidation flexible, improve flesh
Skin lines, reduce damaged skin lines.In addition, in the present invention, ascorbic acid also acts as stabilization, enhancing liposome membrane is strong
The effect of degree, improve the stability of active material.
5th, liposome prepared by the present invention, due to having similar structure to skin, with cutin-softening, can make the work of encapsulating
Property penetration into cuticula, reach site of action, and can skin surface formed one layer of ventilative diaphragm, reduce skin
Water loss, strengthen skin barrier function.
6th, the present invention compared with prior art, a kind of prepared anti-aging liposome composition, passes through various active matters
It is mutually coordinated between matter, mutually promote, having improves skin lines, improves skin elasticity, improves skin hydration ability, reduces
The multi-efficiency such as water loss, enhancing skin barrier function.The lipid physical efficiency of preparation improves the Cutaneous permeation of active ingredient, increase
The bioavailability of active material in skin, the addition of active matter is reduced, reduce product and cost.
Embodiment
With reference to embodiment, the present invention will be described in detail, and embodiment is only the preferred embodiment of the present invention,
It is not limitation of the invention.
Embodiment 1
A kind of anti-aging liposome composition, it is made up of following percetage by weight component：
8% grape fruit peel oil, 1% Atlas cedar bark oil, 0.3% goosefoot seed extract, 35% Surfhope SE Cosme C 1216,
12% 1,3-PD, 0.3% NAP, 4% soybean lecithin, deionized water complement to 100%.
Wherein grape fruit peel oil is prepared by the following manner：
（1）By the pericarp drying of grapefruit, smash to pieces, cross 50-200 mesh sieves；
（2）Will（1）Obtained grape fruit pericarp is immersed in ethanol solution, and 20-30min is smashed in ultrasonic cell disruptor,
Obtained liquid is rotated to dry and removes ethanol.
（3）Will（2）In obtained grape fruit pericarp powder be put into extraction kettle, parameter is：Pressure 33MPa, control temperature
For 25-40 DEG C, extraction time 80-90min, the flow for controlling carbon dioxide is 15L/min-18L/min.
The preparation method of the anti-aging liposome composition is as follows：
（1）Described NAP is dissolved in citrate buffer solution, the concentration of citrate buffer solution
For 0.08mol/L, the amount of citrate buffer solution used causes the pH value of solution system to be adjusted to 6.8, it is molten to obtain aqueous phase
Liquid；
（2）Grape fruit peel oil, Atlas cedar bark oil, the mixing of goosefoot seed extract, Surfhope SE Cosme C 1216,50-65 DEG C
Lower heating stirring, mixing speed 130-150rpm, 30min is stirred, obtains oil-phase solution；
（3）By soybean lecithin and 1,3-PD according to 1：3 is well mixed, supplies excess water；
（4）Under conditions of stirring, by aqueous phase solution and oil-phase solution side homogeneous, while be added to soybean lecithin and 1,3- the third two
In alcoholic solution, in 30-60 degrees Celsius of lower homogeneous 10-20min, 5~10min is ultrasonically treated, miillpore filter is crossed and obtains liposome.
Comparative example 1
A kind of anti-aging liposome composition, it is made up of following percetage by weight component：
8% first squeezing grape fruit peel oil, 1% Atlas cedar bark oil, 0.3% goosefoot seed extract, 35% sucrose lauric
Acid esters, 12% 1,3-PD, 0.3% NAP, 4% soybean lecithin, deionized water complement to 100%.
Wherein grape fruit peel oil is prepared by cold pressing squeezing method.
The preparation method of described anti-aging liposome composition is as follows：
（1）Described NAP is dissolved in citrate buffer solution, the concentration of citrate buffer solution
For 0.08mol/L, the amount of citrate buffer solution used causes the pH value of solution system to be adjusted to 6, obtains aqueous phase solution；
（2）Grape fruit peel oil, Atlas cedar bark oil, the mixing of goosefoot seed extract, Surfhope SE Cosme C 1216,50-65 DEG C
Lower heating stirring, mixing speed 130-150rpm, 30min is stirred, obtains oil-phase solution；
（3）By soybean lecithin and 1,3-PD according to 1：3 is well mixed, supplies excess water；
（4）Under conditions of stirring, by aqueous phase solution and oil-phase solution side homogeneous, while be added to soybean lecithin and 1,3- the third two
In alcoholic solution, in 30-60 degrees Celsius of lower homogeneous 10-20min, 5~10min is ultrasonically treated, miillpore filter is crossed and obtains liposome.
Comparative example 2
A kind of anti-aging liposome composition, it is made up of following percetage by weight component：
8% grape fruit pericarp, 0.3% goosefoot seed extract, 35% Surfhope SE Cosme C 1216,12% 1,3-PD,
0.3% NAP, 4% soybean lecithin, deionized water complement to 100%.
The preparation method of described anti-aging liposome composition is as follows：
（1）Described NAP is dissolved in citrate buffer solution, the concentration of citrate buffer solution
For 0.08mol/L, the amount of citrate buffer solution used causes the pH value of solution system to be adjusted to 7, obtains aqueous phase solution；
（2）Grape fruit peel oil, Atlas cedar bark oil, the mixing of goosefoot seed extract, Surfhope SE Cosme C 1216,50-65 DEG C
Lower heating stirring, mixing speed 130-150rpm, 30min is stirred, obtains oil-phase solution；
（3）By soybean lecithin and 1,3-PD according to 1：3 is well mixed, supplies excess water；
（4）Under conditions of stirring, by aqueous phase solution and oil-phase solution side homogeneous, while be added to soybean lecithin and 1,3- the third two
In alcoholic solution, in 30-60 degrees Celsius of lower homogeneous 10-20min, 5~10min is ultrasonically treated, miillpore filter is crossed and obtains liposome.
Comparative example 3
A kind of anti-aging liposome composition, it is made up of following percetage by weight component：
8% grape fruit peel oil, 1% Atlas cedar bark oil, 0.3% goosefoot seed extract, 35% Surfhope SE Cosme C 1216,
12% 1,3-PD, 4% soybean lecithin, deionized water complement to 100%.
Wherein grape fruit peel oil is prepared by the following manner：
（1）By the pericarp drying of grapefruit, smash to pieces, cross 50-200 mesh sieves；
（2）Will（1）Obtained grape fruit pericarp is immersed in ethanol solution, and 20-30min is smashed in ultrasonic cell disruptor,
Obtained liquid is rotated to dry and removes ethanol.
（3）Will（2）In obtained grape fruit pericarp powder be put into extraction kettle, parameter is：Pressure 33MPa, control temperature
For 25-40 DEG C, extraction time 80-90min, the flow for controlling carbon dioxide is 15L/min-18L/min.
The preparation method of described anti-aging liposome composition is as follows：
（1）Aqueous phase solution is citrate buffer solution, and citrate buffer solution weight is the 0.9% of above-mentioned total formula weight；
（2）Grape fruit peel oil, Atlas cedar bark oil, the mixing of goosefoot seed extract, Surfhope SE Cosme C 1216,50-65 DEG C
Lower heating stirring, mixing speed 130-150rpm, 30min is stirred, obtains oil-phase solution；
（3）By soybean lecithin and 1,3-PD according to 1：3 is well mixed, supplies excess water；
（4）Under conditions of stirring, by aqueous phase solution and oil-phase solution side homogeneous, while be added to soybean lecithin and 1,3- the third two
In alcoholic solution, in 30-60 degrees Celsius of lower homogeneous 10-20min, 5~10min is ultrasonically treated, miillpore filter is crossed and obtains liposome.
Comparative example 4
A kind of anti-aging liposome composition, it is made up of following percetage by weight component：
8% grape fruit peel oil, 1% Atlas cedar bark oil, 0.3% goosefoot seed extract, 35% Surfhope SE Cosme C 1216,
12% glycerine, 0.3% NAP, deionized water complement to 100%, and mixing is uniformly dissolved.
Wherein grape fruit peel oil is prepared by the following manner：
（1）By the pericarp drying of grapefruit, smash to pieces, cross 50-200 mesh sieves；
（2）Will（1）Obtained grape fruit pericarp is immersed in ethanol solution, and 20-30min is smashed in ultrasonic cell disruptor,
Obtained liquid is rotated to dry and removes ethanol.
（3）Will（2）In obtained grape fruit pericarp powder be put into extraction kettle, parameter is：Pressure 33MPa, control temperature
For 25-40 DEG C, extraction time 80-90min, the flow for controlling carbon dioxide is 15L/min-18L/min.
The preparation method of described anti-aging liposome composition is as follows：
（1）Aqueous phase solution, citrate buffer solution are formed using citrate buffer solution dissolving NAP
Weight ratio with NAP is 3：1；
（2）Grape fruit peel oil, Atlas cedar bark oil, the mixing of goosefoot seed extract, Surfhope SE Cosme C 1216,50-65 DEG C
Lower heating stirring, mixing speed 130-150rpm, 30min is stirred, obtains oil-phase solution；
（3）Under conditions of stirring, by aqueous phase solution and oil-phase solution side homogeneous, while be added in glycerine, after stirring
Finished product.
Above example 1 and comparative example 1-4 are added separately in emulsion matrix, and addition is emulsion matrix weight 5%, point
Embodiment 2 and comparative example 5-8 are not prepared.
Skin elasticity, skin shine, percutaneous water loss, skin moisture content are carried out to embodiment 2 and comparative example 5-8
The test of project：Each sample is chosen 30 ages and tried out between the volunteer of 20-35 year, and contrast uses front and rear skin
Elasticity and skin shine.
Table 1：The effect of embodiment and comparative example, assesses test result
| Project | 12 hours moistures（%） | 12 hours through epidermis average moisture turnover rate（%） | Skin elasticity increment（%） | Skin shine increment（%） |
| Embodiment 2 | 78.9 | 0.98 | 2.12 | 4.66 |
| Comparative example 5 | 55.5 | 1.65 | 1.25 | 1.52 |
| Comparative example 6 | 63.1 | 1.70 | 1.38 | 3.75 |
| Comparative example 7 | 67.8 | 1.27 | 1.45 | 2.02 |
| Comparative example 8 | 40.2 | 2.1 | 0.86 | 1.14 |
The grape fruit peel oil added in comparative example 5 is just squeezing grape fruit peel oil, compared with Example 2, glossiness and skin
Elasticity is decreased obviously；Atlas cedar oil, the moisture of skin and the elasticity of skin and the phase of embodiment 2 are not added in comparative example 6
Than, hence it is evident that decline, because the small molecule nutrition composition in skin can not be supplemented with other components together Synergistic, therefore through epidermis
Average moisture turnover rate also substantially increases；Without addition NAP, skin elasticity and skin gloss in comparative example 7
Degree is also decreased obviously, because the melanin of skin long time sedimentation can not be reduced, and removing can not be cooperateed with other raw materials freely
Base, therefore skin elasticity and glossiness amplification are less；Because not taking liposome technology, active material in comparative example 8
Percutaneous absorbtion is reduced, and liposome could not form one layer of moisture film in skin surface, and indices have substantially compared with Example 5
Difference.
Claims (10)
1. a kind of anti-aging liposome composition, it is characterised in that including following weight percent composition：
5-10% grape fruit peel oil；
0.1-5% Atlas cedar bark oil：
0.2-1% goosefoot seed extract；
20-50% Surfhope SE Cosme C 1216；
9-15% 1,3-PD；
0.1-0.5% NAP；
3-5% soybean lecithin；
Deionized water complements to 100%.
2. anti-aging liposome composition according to claim 1, it is characterised in that the weight of described grape fruit peel oil
Amount percentage is 6-8%, and the percentage by weight of described Atlas cedar bark oil is 0.5-3.5%, and described goosefoot seed carries
The percentage by weight for taking thing is 0.2-0.8%.
3. anti-aging liposome composition according to claim 1, it is characterised in that described Surfhope SE Cosme C 1216 weight
Percentage is 25-35%.
4. anti-aging liposome composition according to claim 1, it is characterised in that the weight of described 1,3-PD
Percentage is 7.5-13.5%.
5. anti-aging liposome composition according to claim 1, it is characterised in that described NAP
Percentage by weight be 0.35-0.45%.
6. anti-aging liposome composition according to claim 1, it is characterised in that the weight of described soybean lecithin
Percentage is：2.5-4.5%.
7. the preparation method of the grape fruit peel oil described in a kind of claim 1-6 any one, it is characterised in that including following
Step：
A. by the pericarp of grape fruit it is dry, smash to pieces, cross 50-200 mesh sieves；
B. the grape fruit pericarp that a is obtained is immersed in ethanol solution, 20-30min is smashed in ultrasonic cell disruptor, will
The liquid revolving arrived, which is dried, removes ethanol；
C. the grape fruit pericarp powder obtained in b is put into progress carbon dioxide supercritical extraction in extraction kettle and obtains grape fruit pericarp
Oil, control parameter are：Pressure 20MPa-35MPa, temperature are 25-60 DEG C, extraction time 60-120min, the stream of carbon dioxide
Measure as 10L/min-20L/min.
A kind of 8. preparation method of the anti-aging liposome composition described in claim 1-6 any one, it is characterised in that bag
Include following steps：
（1）Described NAP is dissolved in citrate buffer solution, the concentration of citrate buffer solution
For 0.08mol/L, the amount of citrate buffer solution used causes the pH value of solution system to be adjusted to 6-7.5, obtains aqueous phase
Solution；
（2）Grape fruit peel oil, Atlas cedar bark oil, the mixing of goosefoot seed extract, Surfhope SE Cosme C 1216,50-65 DEG C
Lower heating stirring, mixing speed 80-200rpm, 30min is stirred, obtains oil-phase solution；
（3）By soybean lecithin and 1,3-PD according to 1：3 is well mixed, supplies excess water；
（4）Under conditions of stirring, by aqueous phase solution and oil-phase solution side homogeneous, while be added to soybean lecithin and 1,3- the third two
In alcoholic solution, in 30-60 degrees Celsius of lower homogeneous 10-20min, be ultrasonically treated 5~10min, cross miillpore filter obtain liposome into
Product.
9. a kind of stop type of the anti-aging liposome composition described in claim 1-6 any one containing arbitrary proportion or
The cosmetics of wash type.
10. the cosmetics of stop type according to claim 9 or wash type, it is characterised in that the formulation of the cosmetics
For any one in white shape, emulsus, watery, Gel miles of shape.
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| CN113925812A (en) * | 2021-11-12 | 2022-01-14 | 广州睿森生物科技有限公司 | Composition with effects of promoting sleep and repairing skin and application of composition in cosmetics |
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