CN103520289B - A kind of Chinese medicine composition for the treatment of constipation and its preparation method and application - Google Patents

A kind of Chinese medicine composition for the treatment of constipation and its preparation method and application Download PDF

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CN103520289B
CN103520289B CN201310513326.XA CN201310513326A CN103520289B CN 103520289 B CN103520289 B CN 103520289B CN 201310513326 A CN201310513326 A CN 201310513326A CN 103520289 B CN103520289 B CN 103520289B
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卞佳林
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Zhao Xianliang
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Abstract

本发明涉及一种治疗便秘的中药组合物,其各组分的重量为:肉苁蓉10~15份、当归10~20份、决明子10~15份、瓜蒌仁10~20份、车前子25~30份、白术散8~10份、蜂蜜23~27份、温开水350~450份。同时,本发明还提供一种治疗便秘的中药组合物的制备方法。本发明配方成分全是中草药,使用无副作用,能合理调节人体基机能、改善微循环,能根本治愈便秘。The invention relates to a traditional Chinese medicine composition for treating constipation. The weight of each component is: 10-15 parts of Cistanche, 10-20 parts of Angelica, 10-15 parts of Semen Cassiae, 10-20 parts of Trichosanthes Seed, 25 parts of Plantago Seed ~30 parts, 8~10 parts of Baizhu powder, 23~27 parts of honey, 350~450 parts of warm boiled water. At the same time, the invention also provides a preparation method of the traditional Chinese medicine composition for treating constipation. The ingredients of the formula of the invention are all Chinese herbal medicines, the use has no side effects, can reasonably regulate the basic functions of the human body, improve microcirculation, and can fundamentally cure constipation.

Description

一种治疗便秘的中药组合物及其制备方法和应用A kind of traditional Chinese medicine composition for treating constipation and its preparation method and application

技术领域 technical field

本发明涉及一种中药组合物,更具体的说涉及一种治疗便秘的中药组合物及其制备方法和应用。 The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating constipation and its preparation method and application.

背景技术 Background technique

便秘却十分痛苦,且可导致一些并发症,如食欲及睡眠差。长期便秘可致烦躁,精神紧张。对于年轻人来说,便秘可致内分泌失调,产生脾气暴躁,面部粉刺疮。此外,便秘还可致高烧不退,咳嗽不止。 Constipation is painful and can lead to complications such as poor appetite and sleep. Long-term constipation can cause irritability and nervousness. For young people, constipation can cause endocrine disorders, bad temper, and facial acne sores. In addition, constipation can also cause persistent high fever and persistent coughing.

目前,治疗便秘的药物疗效欠佳不能根除,且易引起副作用。 At present, the curative effect of the medicine for treating constipation is poor and cannot be eradicated, and it is easy to cause side effects.

发明内容 Contents of the invention

为解决现有技术的不足,本发明的目的在于提供一种治疗效果好、安全、疗程短的治疗便秘的中药组合物及其制备方法和应用。 In order to solve the deficiencies of the prior art, the object of the present invention is to provide a Chinese medicinal composition for treating constipation with good therapeutic effect, safety and short course of treatment, as well as its preparation method and application.

为达到上述目的,本发明是通过以下的技术方案来实现的:一种治疗便秘的中药组合物,它主要由下列重量份数的原料药制成:肉苁蓉10~15份、当归10~20份、决明子10~15份、瓜蒌仁10~20份、车前子25~30份、白术散8~10份、蜂蜜23~27份。 In order to achieve the above object, the present invention is achieved through the following technical solutions: a traditional Chinese medicine composition for treating constipation, which is mainly made of the following raw materials in parts by weight: 10 to 15 parts of Cistanche deserticola, 10 to 20 parts of Angelica sinensis , 10-15 parts of cassia seeds, 10-20 parts of melon seeds, 25-30 parts of plantain seeds, 8-10 parts of Baizhu powder, and 23-27 parts of honey.

进一步地,各原料药的用量为:肉苁蓉10份、当归10份、决明子10份、瓜蒌仁10份、车前子25份、白术散8份、蜂蜜23份。 Further, the dosage of each raw material is: 10 parts of Cistanche deserticola, 10 parts of Angelica sinensis, 10 parts of Cassia seed, 10 parts of Gualou seed, 25 parts of Plantago seed, 8 parts of Baizhu powder, and 23 parts of honey.

进一步地,各原料药的用量为:肉苁蓉15份、当归20份、决明子15份、瓜蒌仁20份、车前子30份、白术散10份、蜂蜜27份。 Further, the dosage of each raw material medicine is: 15 parts of cistanche, 20 parts of angelica, 15 parts of cassia seed, 20 parts of melon seeds, 30 parts of plantago seed, 10 parts of atractylodes powder, and 27 parts of honey.

本发明提供的另一技术方案为:一种治疗便秘的中药组合物的制备方法,包括以下步骤: Another technical solution provided by the present invention is: a preparation method of a Chinese medicine composition for treating constipation, comprising the following steps:

(1)按照各原料药的用量称取各原料药; (1) Weigh each API according to the dosage of each API;

(2)头煎工序:将步骤(1)中的肉苁蓉、当归、决明子、瓜蒌仁、车前子、白术散各原料药加水浸泡,所述水量为所有原料药总重量的3~5倍,浸泡10~20分钟,大火煮沸后,文火继续煎煮20~25分钟,滤出药液,得到滤渣; (2) Head decoction process: Soak the raw materials of Cistanche, Angelica, Cassia, Gualou, Plantago, and Baizhusan in step (1), and the amount of water is 3 to 5 times the total weight of all raw materials , soak for 10 to 20 minutes, boil on high heat, continue to decoct on low heat for 20 to 25 minutes, filter out the medicinal liquid, and obtain filter residue;

(3)二煎工序:对步骤(2)中得到的滤渣加水浸泡,此时水量为所有原料药总重量1~2倍,煎煮时间20~30分钟,滤出药液; (3) Second decoction process: soak the filter residue obtained in step (2) with water, at this time, the amount of water is 1 to 2 times the total weight of all raw materials, decoct for 20 to 30 minutes, and filter out the liquid medicine;

(4)合并:将二煎工序中得到的药液与头煎工序中得到的药液混合后加入蜂蜜,搅拌均匀,即得所述治疗便秘的中药组合物。 (4) Combination: mix the medicinal liquid obtained in the second decoction process with the medicinal liquid obtained in the first decoction process, add honey, and stir evenly to obtain the traditional Chinese medicine composition for treating constipation.

上述中药组合物在制备治疗便秘药物中的应用。 Application of the above-mentioned traditional Chinese medicine composition in the preparation of a medicine for treating constipation.

本发明的有益效果是:本发明提供的一种治疗便秘的中药组合物及其制备方法,配方成分全是中草药,使用无副作用,能合理调节人体基机能、改善微循环,能根本治愈便秘,解决患者痛苦。 The beneficial effect of the present invention is: a kind of traditional Chinese medicine composition for treating constipation provided by the present invention and its preparation method, the composition of the formula is all Chinese herbal medicine, use without side effect, can rationally regulate the fundamental function of human body, improve microcirculation, can cure constipation fundamentally, Solve the pain of patients.

具体实施方式 Detailed ways

为更好地理解本发明,下面通过两个实施例对本发明作进一步具体的阐述,但不可理解为对本发明的限定,对于本领域的技术人员根据上述发明内容所作的一些非本质的改进与调整,也视为落在本发明的保护范围内。 In order to better understand the present invention, the present invention will be further elaborated below through two examples, but it should not be understood as a limitation of the present invention, and some non-essential improvements and adjustments made by those skilled in the art according to the content of the above invention , is also considered to fall within the protection scope of the present invention.

实施例1Example 1

一种治疗便秘的中药组合物,它主要由下列重量份数的原料药制成: A traditional Chinese medicine composition for treating constipation, which is mainly made of the following raw materials in parts by weight:

肉苁蓉10份、当归10份、决明子10份、瓜蒌仁10份、车前子25份、白术散8份、蜂蜜23份。 10 parts of cistanche, 10 parts of angelica, 10 parts of cassia seed, 10 parts of melon seeds, 25 parts of plantain seed, 8 parts of atractylodes powder, and 23 parts of honey.

上述一种治疗便秘的中药组合物的制备方法,按照如下步骤进行: The preparation method of the above-mentioned Chinese medicine composition for treating constipation is carried out according to the following steps:

(1)按照各原料药的用量称取各原料药; (1) Weigh each API according to the dosage of each API;

(2)头煎工序:将步骤(1)中的肉苁蓉、当归、决明子、瓜蒌仁、车前子、白术散各原料药加水浸泡,所述水量为所有原料药总重量的3倍,浸泡10分钟,大火煮沸后,文火继续煎煮20分钟,滤出药液,得到滤渣; (2) Head decoction process: Soak Cistanche deserticola, Angelica sinensis, Cassia seed, Gualou seed, Plantago seed and Atractylodes powder in water, the amount of water is 3 times of the total weight of all raw materials, soak After 10 minutes, boil on high heat, continue to decoct on low heat for 20 minutes, filter out the liquid medicine, and obtain filter residue;

(3)二煎工序:对步骤(2)中得到的滤渣加水浸泡,此时水量为所有原料药总重量1倍,煎煮时间20分钟,滤出药液; (3) Second decoction process: add water to soak the filter residue obtained in step (2), at this time, the amount of water is 1 times the total weight of all raw materials, decoct for 20 minutes, and filter out the liquid medicine;

(4)合并:将二煎工序中得到的药液与头煎工序中得到的药液混合后加入蜂蜜,搅拌均匀,即得所述治疗便秘的中药组合物。 (4) Combination: mix the medicinal liquid obtained in the second decoction process with the medicinal liquid obtained in the first decoction process, add honey, and stir evenly to obtain the traditional Chinese medicine composition for treating constipation.

实施例2:一种治疗便秘的中药组合物,它主要由下列重量份数的原料药制成:肉苁蓉15份、当归20份、决明子15份、瓜蒌仁20份、车前子30份、白术散10份、蜂蜜27份。 Embodiment 2: a kind of Chinese medicine composition for the treatment of constipation, it is mainly made of the crude drug of following parts by weight: 15 parts of cistanche, 20 parts of angelica, 15 parts of cassia seed, 20 parts of fennel seed, 30 parts of plantago seed, Baizhu powder 10 parts, honey 27 parts.

上述一种治疗便秘的中药组合物的制备方法,按照如下步骤进行: The preparation method of the above-mentioned Chinese medicine composition for treating constipation is carried out according to the following steps:

(1)按照各原料药的用量称取各原料药; (1) Weigh each API according to the dosage of each API;

(2)头煎工序:将步骤(1)中的肉苁蓉、当归、决明子、瓜蒌仁、车前子、白术散各原料药加水浸泡,所述水量为所有原料药总重量的5倍,浸泡20分钟,大火煮沸后,文火继续煎煮25分钟,滤出药液,得到滤渣; (2) Head decoction process: Soak Cistanche deserticola, Angelica sinensis, Cassia seed, Gualou seed, Plantago seed and Atractylodes atractylodes powder in water, the amount of water is 5 times of the total weight of all raw materials, soak After 20 minutes, boil on high heat, continue to decoct on low heat for 25 minutes, filter out the liquid medicine, and obtain filter residue;

(3)二煎工序:对步骤(2)中得到的滤渣加水浸泡,此时水量为所有原料药总重量2倍,煎煮时间30分钟,滤出药液; (3) Second decoction process: add water to soak the filter residue obtained in step (2), at this time, the amount of water is twice the total weight of all raw materials, decoct for 30 minutes, and filter out the liquid medicine;

(4)合并:将二煎工序中得到的药液与头煎工序中得到的药液混合后加入蜂蜜,搅拌均匀,即得所述治疗便秘的中药组合物。 (4) Combination: mix the medicinal liquid obtained in the second decoction process with the medicinal liquid obtained in the first decoction process, add honey, and stir evenly to obtain the traditional Chinese medicine composition for treating constipation.

实施例3Example 3

一种治疗便秘的中药组合物,它主要由下列重量份数的原料药制成:肉苁蓉13份、当归17份、决明子12份、瓜蒌仁16份、车前子23份、白术散9份、蜂蜜25份。 A traditional Chinese medicine composition for treating constipation, which is mainly made of the following raw materials in parts by weight: 13 parts of cistanche, 17 parts of angelica, 12 parts of cassia seed, 16 parts of melon seeds, 23 parts of plantago seed, and 9 parts of atractylodes powder , 25 parts of honey.

上述一种治疗便秘的中药组合物的制备方法,按照如下步骤进行: The preparation method of the above-mentioned Chinese medicine composition for treating constipation is carried out according to the following steps:

(1)按照各原料药的用量称取各原料药; (1) Weigh each API according to the dosage of each API;

(2)头煎工序:将步骤(1)中的肉苁蓉、当归、决明子、瓜蒌仁、车前子、白术散各原料药加水浸泡,所述水量为所有原料药总重量的4倍,浸泡15分钟,大火煮沸后,文火继续煎煮25分钟,滤出药液,得到滤渣; (2) Head decoction process: Soak the raw materials of Cistanche, Angelica, Cassia, Gualou Ren, Plantago and Baizhusan in step (1), the amount of water is 4 times the total weight of all raw materials, soak 15 minutes, after boiling on high heat, continue to decoct on low heat for 25 minutes, filter out the liquid medicine, and obtain filter residue;

(3)二煎工序:对步骤(2)中得到的滤渣加水浸泡,此时水量为所有原料药总重量1.5倍,煎煮时间25分钟,滤出药液; (3) Second decoction process: soak the filter residue obtained in step (2) with water, at this time, the amount of water is 1.5 times the total weight of all raw materials, decoct for 25 minutes, and filter out the liquid medicine;

(4)合并:将二煎工序中得到的药液与头煎工序中得到的药液混合后加入蜂蜜,搅拌均匀,即得所述治疗便秘的中药组合物。 (4) Combination: mix the medicinal liquid obtained in the second decoction process with the medicinal liquid obtained in the first decoction process, add honey, and stir evenly to obtain the traditional Chinese medicine composition for treating constipation.

以下通过临床病例来进一步阐述本发明所述中药的有益效果。 The beneficial effects of the traditional Chinese medicine of the present invention are further described below through clinical cases.

以下通过临床病例来进一步阐述本发明所述药物的有益效果。 The beneficial effect of the medicine of the present invention will be further elaborated below through clinical cases.

以试验组治疗便秘患者50例,与对照组50例进行比较。试验组:本发明中实施例1-3中所述的中药组合物,水煎服,每日一剂,早晚分服。连续服药14天为1个疗程,每14天复诊一次。观察时间为4个疗程。对照组:采用常规的促动力剂进行治疗,每日三次,14天为1疗程。观察时间为4个疗程。 50 cases of constipation patients were treated in the experimental group, and compared with 50 cases in the control group. Test group: the traditional Chinese medicine composition described in Examples 1-3 of the present invention, decocted in water, one dose per day, divided into morning and evening. Continuous medication for 14 days is a course of treatment, and a follow-up visit is made every 14 days. The observation time was 4 courses of treatment. Control group: treated with conventional prokinetic agents, three times a day, 14 days as a course of treatment. The observation time was 4 courses of treatment.

疗效标准参照国家中医药管理局《中医病证诊断疗效标准》拟定: The curative effect standard is drawn up with reference to the State Administration of Traditional Chinese Medicine "Criteria for Diagnosis and Curative Effect of TCM Disease Syndrome":

1、治愈:临床症状消失; 1. Cure: clinical symptoms disappear;

2、显效:临床症状、体征明显减轻; 2. Significant effect: clinical symptoms and signs are significantly relieved;

3、有效:临床症状、体征减轻,发作频率减少,发作持续时间较短; 3. Effective: the clinical symptoms and signs are alleviated, the attack frequency is reduced, and the attack duration is shorter;

4、无效:症状、体征无改善或加重者。 4. Ineffective: Symptoms and signs are not improved or aggravated.

试验组与对照组疗效比较,见表1。 The curative effect comparison between the experimental group and the control group is shown in Table 1.

表1 试验组与对照组疗效比较 Table 1 Comparison of curative effect between the experimental group and the control group

 the 临床痊愈clinical recovery 显效markedly effective 有效efficient 无效invalid 合计total 有效率(%)Efficient(%) 试验组test group 2020 2020 99 11 5050 9898 对照组control group 22 1010 1515 23twenty three 5050 5454

试验组治疗便秘50例,总有效率达98%,与对照组50例总有效率54%,进行比较,大大优于对照组。说明本发明药物治疗便秘疗效显著,具有良好推广价值。 50 cases of constipation were treated in the experimental group, and the total effective rate was 98%, which was much better than that of the control group compared with 54% of the total effective rate of 50 cases in the control group. It shows that the medicament of the present invention has remarkable curative effect in treating constipation and has good popularization value.

Claims (5)

1. treat a Chinese medicine composition for constipation, it is characterized in that, it is made up of the crude drug of following parts by weight:
Herba Cistanches 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Semen Cassiae 10 ~ 15 parts, Semen Trichosanthis 10 ~ 20 parts, Semen Plantaginis 25 ~ 30 parts, the Rhizoma Atractylodis Macrocephalae
Loose 8 ~ 10 parts, Mel 23 ~ 27 parts.
2., according to a kind of Chinese medicine composition for the treatment of constipation described in claim 1, it is characterized in that, the consumption of each crude drug
For: Herba Cistanches 10 parts, Radix Angelicae Sinensis 10 parts, Semen Cassiae 10 parts, Semen Trichosanthis 10 parts, Semen Plantaginis 25 parts, the Rhizoma Atractylodis Macrocephalae loose 8 parts, Mel 23
Part.
3., according to a kind of Chinese medicine composition for the treatment of constipation described in claim 1, it is characterized in that, the consumption of each crude drug
For: Herba Cistanches 15 parts, Radix Angelicae Sinensis 20 parts, Semen Cassiae 15 parts, Semen Trichosanthis 20 parts, Semen Plantaginis 30 parts, the Rhizoma Atractylodis Macrocephalae loose 10 parts, Mel
27 parts.
4. a kind of preparation method for the treatment of the Chinese medicine composition of constipation described in claim 1, is characterized in that, comprise following
Step:
(1) each crude drug is taken according to the consumption of each crude drug;
(2) head decocts operation: fall apart the Herba Cistanches in step (1), Radix Angelicae Sinensis, Semen Cassiae, Semen Trichosanthis, Semen Plantaginis, the Rhizoma Atractylodis Macrocephalae each crude drug
Soak, the described water yield is 3 ~ 5 times of all crude drug gross weights, soaks 10 ~ 20 minutes, and after big fire is boiled, slow fire continues
Decoct 20 ~ 25 minutes, leach medicinal liquid, obtain filtering residue;
(3) two decoct operation: soak the filtering residue obtained in step (2), and now the water yield is all crude drug gross weights 1 ~ 2
Doubly, decocting time 20 ~ 30 minutes, leaches medicinal liquid;
(4) merge: decoct the medicinal liquid obtained in operation by two and decoct after the medicinal liquid obtained in operation mix with head and add Mel, stirring is equal
Even, obtain the Chinese medicine composition of described treatment constipation.
5. the application of Chinese medicine composition described in claim 1 in preparation treatment constipation medicine.
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