CN102793830A - Pronephrium triphyllum-rheum officinale gel and preparation method thereof - Google Patents
Pronephrium triphyllum-rheum officinale gel and preparation method thereof Download PDFInfo
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Abstract
The invention discloses pronephrium triphyllum-rheum officinale gel and a preparation method thereof, the pronephrium triphyllum-rheum officinale gel comprises the following components: pronephrium triphyllum, rheum officinale, herba commelinae, capparis acutifolia, radix helicteris, borneol, glycerin, carbomer-940, sodium hydroxide, ethyl nipagin ester, anhydrous alcohol, and distilled water. The preparation method comprises the following steps of: A. component weighing; B. medicinal material extraction; C. blank matrix preparation; D. gel preparation.
Description
[technical field]
The present invention relates to the yellow gel of a kind of Serpentis; The invention still further relates to a kind of method for preparing the yellow gel of this Serpentis.
[background technology]
As the existing medicament one of which that is used to treat symptoms such as venom, initial stage skin infection (person bursts), insect bite swell and ache all is with medicine pulverize and substrate mixing gained; This pharmacy particle is big; The effective ingredient stripping is limited, and former plant contains than polychrom without purification process; Be not suitable for that body surface infects purulence and serosity oozes out more person, largely limit its scope of application.
[summary of the invention]
The present invention seeks to have overcome deficiency of the prior art and provide a kind of component simple, have heat-clearing and toxic substances removing, anti-inflammatory analgetic, putrefaction-removing granulation-promoting is applicable to that table infection purulence and serosity ooze out the yellow gel of Serpentis of more disease;
Another object of the present invention is that a kind of method for preparing the yellow gel of this Serpentis is provided.
In order to solve the technical problem of above-mentioned existence, the present invention adopts following technical proposal:
The yellow gel of a kind of Serpentis is characterized in that composed of the following components by weight:
The yellow gel of aforesaid a kind of Serpentis is characterized in that composed of the following components by weight:
The yellow gel of aforesaid a kind of Serpentis is characterized in that composed of the following components by weight:
The present invention prepares the method for the yellow gel of aforesaid any Serpentis, it is characterized in that may further comprise the steps:
A, take by weighing each component: take by weighing Tectaria subtriphlla (Hook. Et Arn.) by weight respectively, Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris, Borneolum Syntheticum, glycerol, carbomer-940, sodium hydroxide, ethyl hydroxybenzoate, dehydrated alcohol, distilled water;
The extraction of B, medical material: get Tectaria subtriphlla (Hook. Et Arn.), Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris, add 10 times of amount 70% alcohol refluxs 2 times, each 1.5h, sucking filtration merges filtrating twice, is concentrated into 1.0-1.5g/mL;
The preparation of C, blank substrate: it is an amount of to get distilled water, adds glycerol, stirs, and slowly adds carbomer-940, and the limit edged stirs, and placement is spent the night, and fully swelling promptly gets blank substrate;
The preparation of D, gel: the medicinal liquid of 1. getting in the steps A slowly adds in the blank substrate, and the limit edged is stirred to evenly, promptly gets pastille substrate; 2. get Borneolum Syntheticum and ethyl hydroxybenzoate, be dissolved in the dehydrated alcohol, add in the pastille substrate of 1. gained, stir, slowly drip NaOH solution then, the limit edged stirs, and adding distil water to 1000 weight portion promptly gets.
The character of part component in the prescription among the present invention:
One, Tectaria subtriphlla (Hook. Et Arn.)
Tectaria subtriphlla (Hook. Et Arn.) is as medicinal, and the beginning is stated from " Guangdong Chinese medicine ", and after this, " national Chinese herbal medicine compilation ", " Guangdong Chinese herbal medicine ", " Guangxi medicinal plants register ", " China's book on Chinese herbal medicine ", " Chinese main plant collection of illustrative plates " etc. all record.
Another name: three marks, Herba pronephrii triphylli " Guangdong Chinese medicine ", Tectaria subtriphlla's " Guangxi medicinal plants register ", Rhizoma Helminthostachydis Zeylanicae " national Chinese herbal medicine compilation), little Rhizoma Homalomenae (Guangxi).
1, source: the dry herb of Thelypteridaceae Meniscium plant three plumage crescent Herba pteridii latiusculi Pronephrium triphyllum (Sw.) Holtt..
2, nature and flavor: mildly bitter flavor, suffering, property is flat.
3, function cures mainly: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, preventing phlegm from forming and stopping coughing.It is swollen to cure mainly the carbuncle furuncle, venom, traumatic injury, eczema, skin pruritus, acute and chronic tracheitis.
Two, Radix Et Rhizoma Rhei
Medical ancient books and records such as " Chinese medicine dictionary ", the Pharmacopoeia of the People's Republic of China are all on the books.Another name: general, yellow good, fire ginseng, skin as, another name for Sichuan Province Radix Et Rhizoma Rhei, Radixet Rhizoma Rhei, cow tongue Radix Et Rhizoma Rhei, bright and beautiful stricture of vagina, give birth to army, Radix Et Rhizoma Rhei.
1, source: be the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim.ex Balf. or Rheum officinale Rheum officinale Baill..
2, nature and flavor: hardship, cold.
3, return through: return spleen, stomach, large intestine, liver, heart channel.
4, function cures mainly: heat and toxic materials clearing away, clearing away heat-fire, hemostasis, detoxifcation, blood circulation promoting and blood stasis dispelling, clearly rush down damp and hot.Be used for gastrointestinal retention, constipation, the conjunctival congestion that goes out inflammation on blood disorder and the pathogenic fire of bleeding due to blood-heat, pharyngalgia, gingival swelling and pain, pathopyretic ulcer, erysipelas and burn and scald, all cards of jaundice, stranguria and congestion.
Three, Herba Chlorophyti Laxi
Alias: mountain leek "medicine plant in Guangxi List", earth Radix "South Main poisonous plants."
1, source: the dry herb of Liliaceae bracketplant platymiscium flower thinning bracketplant Chlorophytum laxum R.Brown.
2, meridian distribution of property and flavor: sweet, little hardship, cold.Poisonous.GUIXIN, spleen channel.
3, function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Be used for venom, treating swelling and pain by traumatic injury.
Four, Radix Capparis Membranaceae
Another name solely tiger dragon, button button, film leaf mallet really rattan, land golden pheasant, rein in youngster's root, Xia Dongdi, the bar potato falls; Put down in writing to some extent at " national Chinese herbal medicine compilation ".
1, source: root and the leaf of Capparidaceae Chinese lime platymiscium Radix Capparis Membranaceae Capparis acutifolia Sweet [C.membranacea Gardn.et Champ.].
2, meridian distribution of property and flavor: bitter, puckery, temperature.Slightly poisonous.
3, function cures mainly: promoting blood circulation to remove blood stasis, wind-expelling pain-stopping.Main traumatic injury congestive edema, amenorrhea, rheumatic arthralgia, laryngopharynx swelling and pain, toothache, stomachache.
Five, Radix Helicteris
Another name hilllock spunyarn, hilllock sesame, field spunyarn, purslane speedwell Herba, Herba lamii barbati, bullshit tree, Amauroderma ruda (Berk) Pat fiber crops, SHANMA, false spunyarn, Semen Sesami head, cattle still tail, hill fiber crops, hoary hair are public, spunyarn first, wild flax first, false numb first, hardship fiber crops, mountain sesame, by spunyarn, sloping sheet public affairs.
1, source: be root or the Herb of Sterculiaceae Radix Helicteris platymiscium Radix Helicteris Helictercs angustifolia L..
2, nature and flavor: hardship, cool in nature; Slightly poisonous.
3, function cures mainly: heat-clearing and toxic substances removing, cough-relieving.Be used for cat fever, tonsillitis, pharyngolaryngitis, parotitis, measles, cough, malaria; Venom is controlled in external, traumatic hemorrhage, hemorrhoid, carbuncle furuncle.
Six, carbomer-940
With tetramethylolmethane etc. and the crosslinked acrylic acid crosslinked resin that obtains of acrylic acid, be one type of very important rheology control agent, the card ripple after the neutralization is outstanding gel-type vehicle; Important use such as thickening suspension are arranged; Technology is simple, and good stability is widely used in emulsion, cream frost, the gel.
1, Chinese synonym: carbomer series; The carboxyl ethylene copolymer; Carbomer; Polyacrylic acid
2, English name: POLY (ACRYLIC ACID)
3, molecular formula: (C
3H
4O
2)
n
Seven, ethyl hydroxybenzoate
1, trade name: ethyl hydroxybenzoate
2, chemical name: ethylparaben
3, nomenclature of drug: ethyl hydroxybenzoate
4, molecular formula: C
9H
10O
3
5, molecular weight: 166.18
6、CAS：120-47-8
7, physical and chemical performance: white crystals, mildly bitter flavor, is soluble in alcohol at the fiber crops of burning, and ether and acetone are almost insoluble in water.
The yellow gel quality control of Serpentis of the present invention:
1 character: the yellow gel of Serpentis of the present invention is the translucent semisolid of pale brown color, uniform and smooth, and denseness is suitable, and stretchability is good.
2 pH value: take by weighing gel 2g, use the 15mL dissolved in distilled water, recording pH value is 6.0～7.0, meets the regulation of relevant percutaneous drug delivery.
3 qualitative identification
Radix Et Rhizoma Rhei: get these article 10g, add methanol 20ml, soaked 1 hour, filter; Remove the 5ml that filtrates, evaporate to dryness, residue add water 10ml makes dissolving, adds hydrochloric acid 1ml again; Reflux 30min, cooling immediately divides 2 joltings to extract with ether, each 20ml; Merge ether solution, evaporate to dryness, residue add chloroform 1ml makes dissolving, as need testing solution.Other gets Radix Et Rhizoma Rhei control medicinal material 0.1g, shines medical material solution in pairs with legal system.Get the emodin reference substance again, add methanol and process the solution that every 1ml contains 1mg, as reference substance solution.Method for preparing by above-mentioned gel prepares the negative sample that does not contain Radix Et Rhizoma Rhei, makes negative controls with the test liquid method for making.According to thin layer chromatography test, draw above-mentioned three kinds of solution each to put in same sodium carboxymethyl cellulose respectively in right amount be on the silica gel thin-layer plate of adhesive, be developing solvent with the upper solution of petroleum ether-Ethyl formate-formic acid (15: 5: 1); Launch; Take out, dry, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the fluorescence principal spot of same color; With the corresponding position of reference substance chromatograph on, show identical orange-yellow fluorescence speckle, put in the ammonia steam smoked after, speckle becomes redness.Negative control is noiseless.
Borneolum Syntheticum: get these article 2g, add ethanol 5mL stirring and dissolving, add 2 of 1% vanillin sulphuric acid liquid, promptly show purple.
The test of 4 finished product stability
4.1 centrifugal test: get 3 each 10g of lot sample article, put in the graduated centrifuge tube, with the centrifugal 30min of rotating speed 3000r/min, the result does not have lamination.
4.2 heat-resisting low temperature resistant test: get 3 lot sample article each an amount of (about 20g), add a cover in the packing box of packing into, in 55 ℃ of constant water bath box, place 6h, in-15 ℃ of refrigerators, place 24h again, gel does not have lamination as a result.
4.3 reserved sample observing: get 3 lot sample samples, preserved respectively 6 months at room temperature, refrigerator, sampling detects during respectively at 1st month, 3 months, 6 months, and the uniformity of gel, transparency, pH value, denseness etc. do not have obviously change as a result, and do not have mildew phenomena.Show that finished product stability is good.
The clinical practice of the yellow gel of Serpentis of the present invention:
1 clinical data is selected insect bite wound, the skin infection from out-patient department, the patient of venom, all is divided into treatment group and matched group at random, each treatment group and the equal no difference of science of statistics of matched group patient (P＞0.05).
2 medications 1. insect bite are hindered: the treatment group is coated with every day 3 times outward with the yellow gel of Serpentis; Matched group uses jidesheng sheyao tablets to mix well into pasty state in right amount with cold water or vinegar, is applied to the affected part, every day 3 times.2. skin infection: the yellow gel external application of the treatment group external Serpentis position of swelling and ache, every day 1 time; Matched group is with No. 6 capsule 0.5g of cephalosporin, and every day 3 times is oral; External 10% YUSHIZHI RUANGAO external application, 1 time/d.3. snakebite swells and ache: matched group: adopt conventional expansion wound, behind the flushing toxin expelling, give Chymotrypsin 4000～8000 μ and dexamethasone 5mg by the position size and add 0.5% lignocaine, 20～40ml and do the local wound sealing, and in wound site external application 50% magnesium sulfate; Give dexamethasone 5～20mg, the quiet notes of furosemide 20mg according to the state of an illness and body weight.And select corresponding antivenin for use according to the Serpentis kind of biting, give infection, prevention tetanus and the Supporting Therapy of suiting the medicine to the illness, and the outbreak of active prevention complication.On treatment group and matched group medication (except the 50% magnesium sulfate) basis, adopt the yellow gel external application of the Serpentis position of swelling and ache, every day 1 time is until detumescence.
3 criterions of therapeutical effect 1. insect bite are hindered: cure: swelling in the 2d, and the pain complete obiteration, wound does not have sepage or ulcer person.Effectively: in the 2d swelling with (or) pain relief, and wound does not form ulcer person.Invalid: in the 2d swelling with (or) pain do not have improvement, or wound ulcer occurs and need change surgical intervention person.2. symptom and sign (red and swollen heat pain) disappears for curing in skin infection: the 3d; Symptom and sign is alleviated or disappearance in the 5d, and the part does not form ulcer person for effective; The 7d symptom and sign does not have to be alleviated or anti-aggravation, or the part ulcer person occurs for invalid.3. snakebite swells and ache: cure: swelling in the 4d, pain complete obiteration, wound does not have downright bad ulcer person.Effectively: swelling and/or pain relief in the 4d, and wound does not form ulcer person.Invalid: swelling and/or pain do not have improvement in the 4d, or ulcer appears in wound, maybe need change surgical intervention person.
4 efficacy result applied statistics software SPSS 17.0 adopt X
2Check comparative control group and treatment group cure rate and total effective rate.The curative effect of treatment group as a result all is superior to matched group, and total effective rate all has significant difference (P＜0.05).See following each table for details.
The table 1 treatment insect bite relatively n (%) of two groups of clinical efficacies that swell and ache
Annotate: with the matched group ratio
*P＜0.05
Two groups of clinical efficacies of table 2 treatment initial stage skin infection are n (%) relatively
Annotate: with the matched group ratio
△P＜0.05
The table 3 treatment snakebite relatively n (%) of two groups of clinical efficacies that swell and ache
Annotate: with the matched group ratio
*P＜0.05
The present invention compared with prior art has following advantage:
One, selecting carbomer CP-940 among the present invention for use is gel-type vehicle; Utilize water-soluable gel on skin, can form thin film and absorb fully that moisture, tack are strong, the skin coupling effect is good, release fast, act on characteristics rapidly; Promote the absorption of medicine, improve bioavailability of medicament.Glycerol is as wetting agent and wetting agent in the prescription; Sodium hydroxide is used to regulate pH value and viscosity; Ethyl hydroxybenzoate is an antiseptic.
Two, the yellow gel reasonable recipe of Serpentis of the present invention, the principal agent Tectaria subtriphlla (Hook. Et Arn.) has the merit of heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling in the side, cures mainly that the carbuncle furuncle is swollen, venom, and pharmacological research shows that Tectaria subtriphlla (Hook. Et Arn.) has obvious anti-inflammatory and analgesic effect; Radix Et Rhizoma Rhei external removing heat from blood removing food stagnancy, reducing swelling and alleviating pain, modern pharmacological research think that Radix Et Rhizoma Rhei has effects such as broad-spectrum antiseptic, antiinflammatory heat clearing away, enhance immunity, hemostasis and promotion wound healing, and the swelling that early stage inflammatory exudate is caused has the obvious suppression effect; And Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris all have heat-clearing and toxic substances removing, anti-inflammatory analgetic effect, and in Guangdong the Zhong Shan area, among the peoplely singly take or mash external application venom mouth with the aquatic foods article and treat venom with Herba Chlorophyti Laxi decocting liquid; The then antibacterial pain relieving of heat clearing away of Borneolum Syntheticum.All medicines share, and gather the merit of heat-clearing and toxic substances removing, anti-inflammatory analgetic altogether, make hot detoxification clear, and putrefaction-removing granulation-promoting promotes wound healing.
Three, Serpentis Huang gel of the present invention use is comfortable, is prone to clean, and meets modern life demand, and the yellow gel of Serpentis of the present invention prepares easy, economical, and is safe in utilization effective, has no side effect.
[specific embodiment]
Describe the present invention below in conjunction with embodiment:
Embodiment 1
The yellow gel of Serpentis of the present invention, composed of the following components:
Tectaria subtriphlla (Hook. Et Arn.) 105g, Radix Et Rhizoma Rhei 105g, Herba Chlorophyti Laxi 70g, Radix Capparis Membranaceae 70g, Radix Helicteris 35g, Borneolum Syntheticum 10g, glycerol 100g, carbomer-940 10g, sodium hydroxide 4g, ethyl hydroxybenzoate 1g, dehydrated alcohol 100mL, distilled water adds to 1000g.
Method for preparing
The extraction of A, medical material: take by weighing Tectaria subtriphlla (Hook. Et Arn.), Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris medicinal material coarse powder respectively by above-mentioned consumption, add 10 times of amount 70% alcohol refluxs 2 times, each 1.5h, sucking filtration merges filtrating twice, is concentrated into to contain raw medicinal herbs 1.5g/mL.
The preparation of B, blank substrate: get glycerol 100g and add in an amount of (about 400mL) distilled water, stir, slowly add carbomer-940, the limit edged stirs, and placement is spent the night, and fully swelling promptly gets blank substrate.
The preparation of C, gel: 1. get the prescription medicinal liquid and slowly add in the blank substrate, the limit edged is stirred to evenly, promptly gets pastille substrate.2. get recipe quantity Borneolum Syntheticum and ethyl hydroxybenzoate, be dissolved in the 100mL dehydrated alcohol, add in the pastille substrate of 1. gained; Stir, slowly drip NaOH solution (0.4mol/mL) then, the limit edged stirs; Adding distil water promptly gets the yellow thick gel of semitransparent brown to full dose 1000g.
Embodiment 2
The yellow gel of Serpentis of the present invention, composed of the following components by weight:
Prepare the method for the yellow gel of this Serpentis, may further comprise the steps:
A, take by weighing each component: take by weighing Tectaria subtriphlla (Hook. Et Arn.) by weight respectively, Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris, Borneolum Syntheticum, glycerol, carbomer-940, sodium hydroxide, ethyl hydroxybenzoate, dehydrated alcohol, distilled water;
The extraction of B, medical material: get Tectaria subtriphlla (Hook. Et Arn.), Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris, add 10 times of amount 70% alcohol refluxs 2 times, each 1.5h, sucking filtration merges filtrating twice, is concentrated into 1.0-1.5g/mL;
The preparation of C, blank substrate: get glycerol and add in an amount of distilled water, stir, slowly add carbomer-940, the limit edged stirs, and placement is spent the night, and fully swelling promptly gets blank substrate;
The preparation of D, gel: the medicinal liquid of 1. getting in the steps A slowly adds in the blank substrate, and the limit edged is stirred to evenly, promptly gets pastille substrate; 2. get Borneolum Syntheticum and ethyl hydroxybenzoate, be dissolved in the dehydrated alcohol, add in the pastille substrate of 1. gained, stir, slowly drip NaOH solution then, the limit edged stirs, and adding distil water to total amount 1000 weight portions promptly get.
Embodiment 3
The yellow gel of Serpentis of the present invention, composed of the following components by weight:
Prepare the method for the yellow gel of this Serpentis, may further comprise the steps:
A, take by weighing each component: take by weighing Tectaria subtriphlla (Hook. Et Arn.) by weight respectively, Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris, Borneolum Syntheticum, glycerol, carbomer-940, sodium hydroxide, ethyl hydroxybenzoate, dehydrated alcohol, distilled water;
The extraction of B, medical material: get Tectaria subtriphlla (Hook. Et Arn.), Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris, add 10 times of amount 70% alcohol refluxs 2 times, each 1.5h, sucking filtration merges filtrating twice, is concentrated into 1.0-1.5g/mL;
The preparation of C, blank substrate: get glycerol and add in an amount of distilled water, stir, slowly add carbomer-940, the limit edged stirs, and placement is spent the night, and fully swelling promptly gets blank substrate;
The preparation of D, gel: the medicinal liquid of 1. getting in the steps A slowly adds in the blank substrate, and the limit edged is stirred to evenly, promptly gets pastille substrate; 2. get Borneolum Syntheticum and ethyl hydroxybenzoate, be dissolved in the dehydrated alcohol, add in the pastille substrate of 1. gained, stir, slowly drip NaOH solution then, the limit edged stirs, and adding distil water to total amount 1000 weight portions promptly get.
Embodiment 4
The yellow gel of Serpentis of the present invention, composed of the following components by weight:
Prepare the method for the yellow gel of this Serpentis, may further comprise the steps:
A, take by weighing each component: take by weighing Tectaria subtriphlla (Hook. Et Arn.) by weight respectively, Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris, Borneolum Syntheticum, glycerol, carbomer-940, sodium hydroxide, ethyl hydroxybenzoate, dehydrated alcohol, distilled water;
The extraction of B, medical material: get Tectaria subtriphlla (Hook. Et Arn.), Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris, add 10 times of amount 70% alcohol refluxs 2 times, each 1.5h, sucking filtration merges filtrating twice, is concentrated into 1.0-1.5g/mL;
The preparation of C, blank substrate: get glycerol and add in an amount of distilled water, stir, slowly add carbomer-940, the limit edged stirs, and placement is spent the night, and fully swelling promptly gets blank substrate;
The preparation of D, gel: the medicinal liquid of 1. getting in the steps A slowly adds in the blank substrate, and the limit edged is stirred to evenly, promptly gets pastille substrate; 2. get Borneolum Syntheticum and ethyl hydroxybenzoate, be dissolved in the dehydrated alcohol, add in the pastille substrate of 1. gained, stir, slowly drip NaOH solution then, the limit edged stirs, and adding distil water to total amount 1000 weight portions promptly get.
Embodiment 5
The yellow gel of Serpentis of the present invention, composed of the following components by weight:
Prepare the method for the yellow gel of this Serpentis, may further comprise the steps:
A, take by weighing each component: take by weighing Tectaria subtriphlla (Hook. Et Arn.) by weight respectively, Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris, Borneolum Syntheticum, glycerol, carbomer-940, sodium hydroxide, ethyl hydroxybenzoate, dehydrated alcohol, distilled water;
The extraction of B, medical material: get Tectaria subtriphlla (Hook. Et Arn.), Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris, add 10 times of amount 70% alcohol refluxs 2 times, each 1.5h, sucking filtration merges filtrating twice, is concentrated into 1.0-1.5g/mL;
The preparation of C, blank substrate: get glycerol and add in an amount of distilled water, stir, slowly add carbomer-940, the limit edged stirs, and placement is spent the night, and fully swelling promptly gets blank substrate;
The preparation of D, gel: the medicinal liquid of 1. getting in the steps A slowly adds in the blank substrate, and the limit edged is stirred to evenly, promptly gets pastille substrate; 2. get Borneolum Syntheticum and ethyl hydroxybenzoate, be dissolved in the dehydrated alcohol, add in the pastille substrate of 1. gained, stir, slowly drip NaOH solution then, the limit edged stirs, and adding distil water to total amount 1000 weight portions promptly get.
Claims (4)
1. the yellow gel of a Serpentis is characterized in that composed of the following components by weight:
2. the yellow gel of a kind of Serpentis according to claim 1 is characterized in that composed of the following components by weight:
3. the yellow gel of a kind of Serpentis according to claim 2 is characterized in that composed of the following components by weight:
4. preparation is characterized in that may further comprise the steps like the method for the yellow gel of any Serpentis in the claim 1 to 3:
A, take by weighing each component: take by weighing Tectaria subtriphlla (Hook. Et Arn.) by weight respectively, Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris, Borneolum Syntheticum, glycerol, carbomer-940, sodium hydroxide, ethyl hydroxybenzoate, dehydrated alcohol, distilled water;
The extraction of B, medical material: get Tectaria subtriphlla (Hook. Et Arn.), Radix Et Rhizoma Rhei, Herba Chlorophyti Laxi, Radix Capparis Membranaceae, Radix Helicteris, add 10 times of amount 70% alcohol refluxs 2 times, each 1.5h, sucking filtration merges filtrating twice, is concentrated into 1.0-1.5g/mL;
The preparation of C, blank substrate: it is an amount of to get distilled water, adds glycerol, stirs, and slowly adds carbomer-940, and the limit edged stirs, and placement is spent the night, and fully swelling promptly gets blank substrate;
The preparation of D, gel: the medicinal liquid of 1. getting in the steps A slowly adds in the blank substrate, and the limit edged is stirred to evenly, promptly gets pastille substrate; 2. get Borneolum Syntheticum and ethyl hydroxybenzoate, be dissolved in the dehydrated alcohol, add in the pastille substrate of 1. gained, stir, slowly drip NaOH solution then, the limit edged stirs, and adding distil water to 1000 weight portion promptly gets.
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| CN105106475A (en) * | 2015-09-25 | 2015-12-02 | 青岛云天生物技术有限公司 | Traditional Chinese medicine gel used for treating toxin-accumulating rotting and ulcerating type bedsores during clinical nursing |
| CN105168629A (en) * | 2015-09-30 | 2015-12-23 | 青岛云天生物技术有限公司 | Traditional Chinese medicine gel for treating qi-stagnation and blood stasis type decubitus |
| CN105497380A (en) * | 2015-12-25 | 2016-04-20 | 中山诺顿科研技术服务有限公司 | Traditional Chinese medicine for treating snake venom and preparation method thereof |
| CN105560688A (en) * | 2015-12-25 | 2016-05-11 | 中山诺顿科研技术服务有限公司 | Composition for treating snake venom and preparation method thereof |
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| CN105106475A (en) * | 2015-09-25 | 2015-12-02 | 青岛云天生物技术有限公司 | Traditional Chinese medicine gel used for treating toxin-accumulating rotting and ulcerating type bedsores during clinical nursing |
| CN105168629A (en) * | 2015-09-30 | 2015-12-23 | 青岛云天生物技术有限公司 | Traditional Chinese medicine gel for treating qi-stagnation and blood stasis type decubitus |
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