WO2011016652A2 - Composition for controlling anal fistulae and method for preparing same - Google Patents

Abstract

The present invention relates to a method for preparing a composition for controlling anal fistulae, comprising: a step of mixing a predetermined effective amount of natural safflower, Radix notoginseng, Lightyellow Sophora, Radix elecampane, Rumex, pine resin, Sassafras tree, Radix glycyrrhizae, Testudinis carapax, Rhizoma rhei, Herba Ephedrae, Natrii sulfas, Herba Menthae, Radix Paeoniae, Aconiti tuber, Corni fructus, gypsum and Radix phellodendri materials with an aqueous medium to prepare a basic mixture; a step of extracting the basic mixture using water for 1 to 2 hours at a temperature of approximately 65 to 75°C to prepare an aqueous mixture; a step of filtering the aqueous mixture to prepare a filtrate; and a step of evaporating the filtrate such that the filtrate has a moisture content of 30% to obtain an extract which can be used as a therapeutic agent for hemorrhoids including anal fistulae. The present invention also provides a composition for controlling anal fistulae prepared by the method.

Description

Antichirutic composition and preparation method thereof

The present invention relates to an antichirutic composition made of a natural substance and a method for producing the same. More specifically, the present invention, safflower, Notoginseng Radix, Lightyellow Sophora, Elecampane Redix, Rumex, Pine Resin, Sasa Sassafras Tree, Glycyrrhizae Radix, Testudinis Carapax, Rhei Rhizoma, Ephedrae Herba, Natrii Sulfas, Minthae Herba, Pessica (Pasoniae Radix), Rich ( The present invention relates to a composition using an extract of a natural substance obtained from a combination of Acontii Tuber, Corni Fructus, Gypsum, and Pelladendri Radix, and a method for preparing the same.

Several types of anti-hemorrhoid materials obtained from natural materials are known. For example, Korean Patent No. 10-0173393 discloses an anti-hemorrhoidal composition comprising Mugwort, Yin Yange Huo, and Buckwheat powder at 10: 10: 1.5% by weight. The composition was mixed with 10 g of Jangyeomyeong and 10 g of Trichophyte herb, and the initial mixture was decanted with 500 mL of water at a temperature of 100 ° C. for 30 minutes to prepare 200 mL of extract, 200 mL of the extract, 1.5 g of buckwheat flour and 1000 mL of brine. It is obtained by mixing and finally preparing a liquid extract that can be applied to the anus.

Republic of Korea Patent No. 10-0364429 No. 30: 30: 20: 20% by weight of the fat (Salat Burnet Root), Samchigeun (Wormwood), Honey Goat Weed and Yin Yang (Chinese Matrimony Vine Root), An anti-hemorrhoid composition is disclosed that further comprises one or two selected from the group consisting of Korean Schisandra, Apricot Seed, and Scholar Tree Flower in an amount of about 30% by weight.

U.S. Pat.No. 6,916,494 of the inventors discloses an anti-hemorrhoid composition and natural liquors such as licorice, earwood, antler, rhubarb, ephedra, forget-me-not, bark, peppermint, halves, peony, rich, cornus, gypsum, ginseng, rosacea, talc and yellow white A predetermined amount of material was added to the aqueous medium to form a base mixture, the base mixture was extracted with water at about 70 to 80 ° C. for 1 to 2 hours to form an aqueous mixture, and the aqueous mixture was filtered to prepare a filtrate, A method of preparing an extract that can be used as a therapeutic agent for hemorrhoidal diseases by evaporating the filtrate to a moisture content of 30% is disclosed.

However, such a conventional product and manufacturing method can not be sure that the treatment of hemorrhoids disease fundamentally and effectively. In addition, these conventional products and methods of preparation are not effective for alleviating anal fistula in a short time.

However, natural substances such as safflower, samchil-geun, yeongmyeong, cedar, swimming, rosin, sasapras, licorice, earpan, rhubarb, ephedra, forget-me-not, peppermint, peony, rich, cornus, gypsum, and yellow-white, respectively, are found in 8.4: 12.8: 5.2: 5.2: 8.4: 8.4: 2.8: 8.4: 5.2: 5.2: 2.8: 8.4: 5.2: 5.2: 5.2: 2.8: 5.2: 2.8: 2.8: 2.8: 8.4: 5.2 It is not known.

Moreover, no method of the prior art discloses anti-chiro extracts comprising extracts obtained from these natural substances. Therefore, it is desirable to develop improved anti-chiropractic compositions and methods for their preparation to effectively treat dental disease and effectively alleviate the itch associated with hemorrhoidal disease.

It is therefore an object of the present invention to provide an anti-chiropractic composition obtained from a natural substance which eliminates the above problems exhibited in conventional anti-chiropractic compositions and methods of preparation and methods of making the same.

Another object of the present invention is to use extracts obtained from safflower, samchileun, Youngmyeong, Mohyang, swimming, rosin, Sasapras, licorice, ear plate, rhubarb, ephedra, manganese, peppermint, peony, rich, cornus, gypsum, and yellow white It is to provide a composition.

Other objects of the present invention are natural materials such as safflower, samchil-geun, English, cedar, swimming, rosin, sasafras, licorice, ear, rhubarb, ephedra, forget-me-not, mint, peony, rich, cornus, gypsum, and Sulfur white from 8.4: 12.8: 5.2: 5.2: 8.4: 8.4: 2.8: 8.4: 5.2: 5.2: 2.8: 8.4: 5.2: 5.2: 5.2: 2.8: 5.2: 2.8: 2.8: 2.8: 8.4: 5.2 wt% It is to provide a method for producing the obtained anti-chiru extract.

It is a further object of the present invention to provide a medical extract of natural substances for treating and / or alleviating the symptoms of a patient having a fistula disease and / or associated itching disease.

Further scope of applicability of the present invention will become apparent from the following detailed description of the invention. However, while the description and the specific examples set forth preferred embodiments of the invention, it will only be apparent to those skilled in the art that various changes and modifications will be apparent to those skilled in the art within the spirit and scope of the invention. It is to be understood that this is for illustration.

Hereinafter, the present invention will be described in more detail. The present invention is a natural material, that is, Safflower (Pyote), Notoginseng Radix, Lightyellow Sophora, Elecampane Redix, Rumex (Yellow Duck), Pine Resin, Sasapras ( Sassafras (Cinnamomum) tree, Glycyrrhizae Radix, Earpan (Testudinis Carapax), Rhubarb (Rhei Rhizoma), Ephedrae Herba, Natrii Sulfas, Minthae Herba, Peony (Pasoniae Radix) An anti-chiropractic composition for use as a medical extract, made from Acontii Tuber, Corni Fructus, Gypsum, and Pelladendri Radix, is provided.

Water, sand, clay, dust by washing and pre-processing some of the natural substances such as safflower, samchimus, Youngmyeong, Mohyang, swimming, Sasapras, licorice, rhubarb, ephedra, peppermint, peony, rich, cornus, and yellow white Remove your back. After drying these materials to about 5% moisture content, they are mixed together in a predetermined weight ratio and cut to a length of about 1 cm. After pretreatment, the remaining natural substances listed above, namely earwood, forget-me-not, gypsum and rosin, are added to the mixture in predetermined amounts.

At this time, the natural materials, that is, safflower, samchileun, Youngyeong, Mokyang, swimming, rosin, Sasapras, licorice, ear plate, rhubarb, ephedra, manganese, peppermint, peony, rich, cornus, gypsum, and yellow white, respectively About 7-9, about 11-4, about 4-6, about 4-6, about 7-9, about 7-9, about 2-4, about 7-9, about 4-6, about 4-6, About 4-6, about 2-4, about 4-6, about 2-4, about 2-4, about 7-9 and about 4-6% by weight, preferably about 8.4: 12.8: 5.2: 5.2: 8.4 : 8.4: 2.8: 8.4: 5.2: 5.2: 2.8: 8.4: 5.2: 5.2: 5.2: 2.8: 5.2: 2.8: 2.8: 2.8: 8.4: 5.2 by weight.

The mixture is introduced into an extractor containing 6 times the water of the mixture and soaked for about 1-2 hours at a temperature of about 65-75 ° C. The extracted mixture is first filtered through a centrifuge and the filtrate is again filtered through a microfilter. At this time, the aromatic vapor collected in the extractor is recovered, concentrated and reintroduced into the filtrate obtained from the initial mixture. The filtrate is increased with an automatic vacuum evaporator until the liquid component is about 30%. This concentrated liquid may be administered in the form of topical extracts, preferably for the treatment or alleviation of healed diseases. The concentrated liquid may also be dried in a dry spray to produce a powdered product. The powder may be formulated in the form of tablets, pills, suppositories, or ointments in a conventional manner for use as an anti-dental pharmaceutical product or health food.

In a preferred aspect of the present invention, each of about 10% by weight licorice root and ginseng are preheated to room temperature in a soak for about 2 hours prior to addition to the mixture of natural substances to further improve anti-chiropractic efficiency. The ginseng is preferably made in Korea.

In another preferred aspect of the present invention, in order to further improve the anti-chiropractic efficiency of the extract composition prepared by the process of the present invention, about 1-2% by weight of other natural substances, eg For example: Puerariae Radix, Wolfberry (Lycii Fructus), Gilkyung (Platycodi Radix), Angelicae Gignantis Radix, Fuling (Poria Cocas Wolf), Rehmanmiae Radix, Schizandrae Fructus, Peony (Paloniae Radix) ), Ponciri Fructus, Nepetae Spica, Astragali Radix, and Cortisidis Rhizoma may each be added to the mixture.

The natural substance used in the present invention has the following components. Safflower contains mascalin, styrex oil, limolic acid and egonal. Ginseng root contains saponin, quercetin, β-sitosteral and aucosteral. English name contains alkaloids, flavonoids, β-matrin and β-oxymethrin. Woody skin contains allantolate, isoalantolactone, sequiterpenes and alkaloids. Swimming contains anthroquinones, glycosides, oxalates and tannins. Rosin contains essential oils. Sasapras trees contain volatile oils, saprols and 1-hydroxysaprol,

Licorice root contains glycyrrhizin, liquiditinine and liquiditin. Ear plates contain colloids, lipids and calcium salts. Rhubarb contains emodin, chrysopanol and lanes. Ephedra contains ephedrine, pseudo-ephedrine and 1-norephedrine. The forget-me-not contains Na ₂ SO ₄ 10H ₂ O. Peppermint contains menthol, menton and calpen. Peony root contains peonyflorin, oxypaloniproline and tannin. The rich contain aconitine, mesaconitin and hipacinitin. Cornus contains malonisides, roguenin and cornine. Gypsum contains calcium sulfate, and yellow-white roots contain beverin, obakunone and ovakullactone.

The invention also provides a composition for the treatment of hemorrhoidal diseases, e.g., dental floss, external teeth, internal teeth, bloody stool, anal prolapse by administering 0.05 to 0.5 g / kg body weight / day, preferably 0.07 to 0.32 g / kg body weight / day, to a mammal. (anus prolapsingo), skin rashes around the anus, and the like.

In order for the dry composition to have the maximum effect in treating the stoma, the dry composition should be administered orally about 4-6 times a day, preferably three times between meals. The composition according to the invention is contained in the tablet preferably in a dry composition of 0.5 to 1.5 g, more preferably 1 g. If the composition according to the invention is in the form of a powder, pill, or ointment, it will generally contain 1-3 g of dry composition. For use in the form of an extract, the extract contains about 30% moisture content of the beverage or tea.

The anti-chiropractic composition according to the present invention is very effective in the treatment of hemorrhoidal diseases such as dental floss, external hemorrhoids, internal hemorrhoids, bloody stools, anus prolapsingo, skin rash around the anus, and so on. It is a very useful invention.

The present invention is more specifically illustrated through the following examples. However, these examples are illustrative only and should not be considered as limiting the scope of the invention.

Example 1

First, sulfuric acid, samchileun, Youngmyeong, Mokyang, swimming, Sasapras trees, licorice, rhubarb, ephedra, peppermint, peony, rich, cornus, gypsum and yellow white were washed with water to remove sand, clay and dust. These natural materials were washed and dried to approximately 5% moisture content.

168 g of sulfide, 256 g of three roots, English 104 g, cedar 104 g, swimming 168 g, sasapras 56 g, licorice 168 g, rhubarb 104 g, ephedra 104 g, mint 104 g, peony 56 g, rich 56 g 56 g of cornus oil and 104 g of sulfur white were cut to a particle size of about 1 cm and mixed together. To the mixture obtained above was added 104 g of ear boards, 56 g of forget-me-not, 168 g of gypsum and 168 g of rosin. The mixture was then placed in an extractor equipped with a directional vapor collector. 12 L of water was added to approximately 2 kg of the mixture in the extractor. The mixture in the extractor was heated to about 75 ° C. for 1 hour and then extracted.

The aqueous mixture was filtered first in a centrifuge and then filtered again with a microfilter. The aromatic vapor distilled from the mixture was condensed and added to the filtrate as aromatic liquid. The filtrate was evaporated through automatic vacuum addition to a water content of about 30% to produce an extract useful as an anti-chirotic composition in extract form. At this time, the concentrated liquid was dried through a dry spray to prepare granulation formulations, tablet formulations, pill formulations, ointment formulations and the like for use as anti-dental medicine, beverage or tea.

Example 2

Natural materials were cleaned and cut as in Example 1 above. First, 200 g of licorice and 200 g of Korean ginseng were preheated to a temperature of 25 ° C. in a immersion vessel containing 6 times the number of water for 2 hours. Licorice, ginseng and liquid mixture in the soak was transferred to the extractor. Subsequently, safflower 168g, Youngmyeong 104g, swimming 104g, rhubarb 104g, ephedra 104g, mint 104g, peony 56g, rich man 56g, samchil 168g, yellow white 104g, ear plate 104g, forget-me-not 104g, gypsum 168g, sasapras 56g , And 168 g of rosin were added. The procedure of Example 1 was then repeated to prepare anti-chiropractic compositions and teas for use in treating and alleviating hemorrhoidal disease.

Test Example 1: Treatment of Chiru

Won s. Won S. Lee is a 61-year-old male weighing 72 kg who has been diagnosed with chronic fistula and suffered from the disease for at least seven years. Symptoms with abdominal pain were especially severe after drinking alcoholic beverages or eating spicy foods. Sciatica was also severe. So he could not drive. He received an extract treatment according to the invention at Kyounghee Herb's (inventor's clinic) for 60 consecutive days twice in 15 day intervals. During the first half of the course of treatment, four tablets were taken daily between meals. After the first half of the treatment, it was noted that the dental floss, bloody stool, abdominal pain and sciatic pain were significantly reduced. After 60 days, the fistula, bloody stool, abdominal pain and sciatic pain disappeared.

Test Example 2 Treatment of Anti-Aggression

Sun Jay. Il J. Kim, a 42-year-old woman weighing 51kg, has been diagnosed with severe hemorrhoids with prolapse for eight years. She was treated for 1 month with the extract according to the present invention in Kyung Hee herb, then the symptoms were alleviated, and after drinking the extract for more than 4 months, the anti-death was completely treated.

Test Example 3 Treatment of Blood Stool

SJ. Suk J. Lee, 55, weighs 70kg, was diagnosed with chronic bloody stools and suffered from the disease for about seven years. Symptoms with severe abdominal pain were noticeable. He received two months of tea treatment according to the present invention at Kyung Hee Herb, and within two months abdominal pain and bloody stool were treated.

Test Example 4: Treatment of Chiru

M. Jay. Myong J. Park is a 37-year-old woman weighing 53 kg, with severe gestation, especially during menstruation. She received a tablet and tea treatment according to the invention from Kyung Hee Herb for 3 months, after which the gingival was completely cured.

Test Example 5: Treatment of Chiru

Jung H. Jung H. Park is a 31-year-old woman weighing 50 kg and has had a serious chronic fistula for five years. She received a tea treatment according to the invention at Kyung Hee Herb for 3 months, after which the gingival was completely cured.

It will be apparent that the invention described as described above may be modified in various ways. Such modifications are not to be regarded as a departure from the spirit and scope of the present invention, and all such modifications which will be apparent to those skilled in the art are intended to be included within the scope of the following claims.

Claims (10)

1. Safflower, Notoginseng Radix, Lightyellow Sophora, Elecampane Redix, Rumex, Pine Resin, Sassafras (Cinnamomum), Glycyrrhizae Radix, Testudinis Carapax, Rhei Rhizoma, Ephedrae Herba, Natrii Sulfas, Mint Herba, Pesoniae Radix, Acontii Tuber, Corni Fructus, Gypsum Gypsum), and the extract of Pelladendri Radix in a pharmaceutically effective amount.
2. According to claim 1, The safflower is 7-9% by weight, Samchil muscle is 4-11% by weight, English is 4-6% by weight, the neck is 4-6% by weight, swimming is 7-9% by weight, rosin is 7-9% by weight, Sasapras wood 2-4% by weight, licorice 7-9% by weight, earwood 4-6% by weight, rhubarb 4-6% by weight, ephedra 4-6% by weight, forget-me-not 4-6% by weight, mints 7-9%, peony 7-9%, rich man 2-4%, cornus 2-4%, gypsum 7-9%, and yellow white 4 Anti-chirophyl composition comprising in an amount of -6% by weight.
3. According to claim 1, The safflower is 8.4% by weight, Shamil root is 12.8% by weight, Youngmyeong is 5.2% by weight, neck fragrance 5.2% by weight, swimming is 8.4% by weight, rosin is 8.4% by weight, Sasapras 2.8 weight %, Licorice is 8.4% by weight, ear is 5.2% by weight, rhubarb is 5.2% by weight, ephedra is 5.2% by weight, forget-me-not is 5.2% by weight, mint is 8.4% by weight, peony is 8.4% by weight, rich is 2.8% by weight, Corn oil is 2.8% by weight, gypsum is 8.4% by weight, and anti-yellowing composition characterized in that it is contained in an amount of 5.2% by weight.
4. Safflower is 8.4% by weight, Shamil root is 12.8% by weight, English is 5.2% by weight, Neck is 5.2% by weight, Swimmer is 8.4% by weight, Rosin is 8.4% by weight, Sasapras is 2.8% by weight, Licorice is 8.4% by weight , Ear weight 5.2%, Rhubarb 5.2%, Ephedra 5.2%, Manganese 5.2%, Peppermint 8.4%, Peony 8.4%, Rich 2.8%, Cornus 2.8%, Gypsum Is 8.4% by weight, and sulfur white in an amount of 5.2% by weight.
5. (a) Pharmaceutically effective amounts of natural substances safflower, samchimus, yeongmin, cedar, swimming, rosin, sasapras, licorice, earpan, rhubarb, ephedra, forget-me-not, mint, peony, rich, cornus, gypsum and yellow white in aqueous media Mixing together to form an initial mixture;

   (b) extracting the initial mixture with water at a temperature of 65-75 ° C. for 1-2 hours to produce an aqueous mixture;

   (c) filtering the aqueous mixture to produce a filtrate; And

   (d) preparing the pharmaceutical extract by evaporating the filtrate to a water content of 30%

   Method of producing an anti-chiru composition.
6. According to claim 5, The safflower is 7-9% by weight, Shamil root is 4-11% by weight, Youngyeong is 4-6% by weight, Mokyang is 4-6% by weight, Swimming is 7-9% by weight, 7-9% by weight, Sasapras wood 2-4% by weight, licorice 7-9% by weight, earwood 4-6% by weight, rhubarb 4-6% by weight, ephedra 4-6% by weight, forget-me-not 4-6% by weight, mints 7-9%, peony 7-9%, rich man 2-4%, cornus 2-4%, gypsum 7-9%, and yellow white 4 A method for the preparation of an anti-chiropractic composition, comprising an amount of -6% by weight.
7. According to claim 6, The safflower is 8.4% by weight, Shamil root is 12.8% by weight, Youngmyeong is 5.2% by weight, neck is 5.2% by weight, swimming is 8.4% by weight, rosin is 8.4% by weight, Sasapras 2.8 weight %, Licorice is 8.4% by weight, ear is 5.2% by weight, rhubarb is 5.2% by weight, ephedra is 5.2% by weight, forget-me-not is 5.2% by weight, mint is 8.4% by weight, peony is 8.4% by weight, rich is 2.8% by weight, Cornus milk is 2.8% by weight, gypsum is 8.4% by weight, and yellow and white are contained in an amount of 5.2% by weight.
8. 6. The method of claim 5, wherein licorice and ginseng are preheated in a soak for 2 hours at room temperature and then mixed with other natural substances.
9. The method of claim 5, wherein the extraction step is performed at 75 ° C. for 1 hour.
10. Anti-chiropractic composition comprising an extract prepared according to the method of claim 5