CN103520315A - Medicinal composition for treating gynecological vaginitis and preparation method of medicinal composition - Google Patents
Medicinal composition for treating gynecological vaginitis and preparation method of medicinal composition Download PDFInfo
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- CN103520315A CN103520315A CN201310451034.8A CN201310451034A CN103520315A CN 103520315 A CN103520315 A CN 103520315A CN 201310451034 A CN201310451034 A CN 201310451034A CN 103520315 A CN103520315 A CN 103520315A
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Abstract
The invention discloses medicinal composition for treating gynecological vaginitis and a preparation method of the medicinal composition. The medicinal composition comprises the active components: a hawthorn kernel extract and a comfrey extract, has good bactericidal and insecticidal effects, and has a therapeutic effect on vaginitis caused by bacteria, fungi and trichomonas infection.
Description
Technical field
The invention belongs to field of medicaments, relate to a kind of pharmaceutical composition for the treatment of gynecology colpitis and preparation method thereof.
Technical background
Vaginitis is the inflammation of connective tissue under vaginal mucosa and mucosa, and the character of vaginal secretions changes and pruritus vulvae is main clinical characters clinically, and sexual anhedonia is also common, infects while involving urethra, can occur the symptoms such as urodynia, urgent micturition.Common vaginitis has monilial vaginitis, trichomonal vaginitis, bacterial vaginosis, aerobe vaginitis, Combination vaginitis.Number of the infected is ascendant trend year by year in recent years, and mixed infection also raises to some extent.There is some women not pay attention to, and do not seek medical advice in time, cause the generation of the diseases such as female pelvic inflammation, infertility, have a strong impact on women's physical and mental health.Vaginitis is common gynecological disease, frequently-occurring disease, and easy infection, relapse rate are high, and radical cure difficulty is also the key factor that affect women 's life quality, endangers women and fetus.Domestic literature report, the sickness rate of outpatients of gynecology accounts for 19.7%.Therefore, pay attention to all kinds of colpitic preventions and treat quite important.
Fructus Crataegi (Crataegus pinnatifida Bge.) belongs to Rosaceae Crataegus plant, sour in the mouth, sweet, and slightly warm in nature, returns spleen, stomach, Liver Channel.Fructus Crataegi has the effect of promoting digestion and removing stagnation, blood circulation promoting and blood stasis dispelling, is clinically mainly used in that dyspepsia is not changed and postpartum stagnation stomachache, and the treatment of hypertension, coronary heart disease, hyperlipidemia.Chemical composition in Fructus Crataegi has multiformity, comprises flavonoid, oligomeric flavanoid, organic acid, triterpenes, steroid, monoterpenes, amino acids, lignanoids, and wherein flavonoid is main bioactive ingredients.At present relatively many to the research of Fructus Crataegi and leaf, but less to the research of Semen Crataegi.Recent research report shows that the extract of Semen Crataegi has good bactericidal effect, studies show that of this laboratory, and the Semen Crataegi extract of 0.1mg/mL reaches 98% to the killing rate of staphylococcus aureus.And Semen Crataegi extract, to skin and mucosa nonirritant, can be used for skin and mucosa delivery.
Radix Arnebiae (Radix Lithospermi) is clinical conventional Chinese medicine, and the Pharmacopoeia of the People's Republic of China is recorded, and it is cold in nature, sweet-salty, GUIXIN Liver Channel, has removing heat from blood, effects such as rash, invigorating the spleen and replenishing QI of invigorating blood circulation, detoxify, and is clinically mainly used in treating that heat in blood poison is contained, macule purple is black, measles without adequate eruption, skin infection eczema, burn due to hot liquid or fire etc.According to the literature, it has good curative effect to treatment cervical erosion and vaginitis.
The present invention, by Semen Crataegi extract and Radix Arnebiae extract compatibility, is used for the treatment of gynaecologic vaginal inflammation, and technique of the present invention is simple, and cost is low, and polytype vaginitis is all had to therapeutic effect.
Summary of the invention
The object of the present invention is to provide a kind of colpitic pharmaceutical composition and preparation method thereof that is used for the treatment of, compatibility is simple, and cost is low, and polytype vaginitis is all had to therapeutic effect.
The technical scheme adopting is:
1. one kind is used for the treatment of colpitic pharmaceutical composition and preparation method thereof, it is characterized in that pharmaceutical composition is formed by Semen Crataegi extract and Radix Arnebiae extract assembly.
2. pharmaceutical composition according to claim 1, the weight proportion that it is characterized in that Semen Crataegi extract is 1-10 part, the weight proportion of Radix Arnebiae extract is 1-10 part.
3. pharmaceutical composition according to claim 1, the weight proportion that it is characterized in that Semen Crataegi extract and Radix Arnebiae extract is 1:5～5:1.
4. the preparation method of pharmaceutical composition according to claim 1, is characterized in that extraction is solvent extraction method and chromatography with the method for separated Semen Crataegi and Radix Arnebiae extract.
5. the preparation method of pharmaceutical composition according to claim 4, is characterized in that, Semen Crataegi drying is pulverized, cross 20 mesh sieves, through the organic solvent heating and refluxing extraction of 50-80% 2-3 time, after extracting liquid filtering, merge, be evaporated to extractum shape, dry, obtain Semen Crataegi extract.
6. the preparation method of pharmaceutical composition according to claim 4, is characterized in that, the organic solvent reflux, extract, of Radix Arnebiae (Radix Lithospermi) use 50-100% 2-3 time, merges after extracting liquid filtering, is evaporated to extractum shape, dry, obtains Radix Arnebiae extract.
7. according to the preparation method of the pharmaceutical composition described in claim 5 and 6, it is characterized in that, organic solvent used is the mixture of ethanol, methanol, acetone, ethyl acetate or its any several solvents.
8. pharmaceutical composition according to claim 1 and preparation method thereof, is characterized in that, is equipped with appropriate pharmaceutic adjuvant, makes the dosage forms such as suppository, gel, ointment, ointment.
The specific embodiment:
Following examples are intended to further illustrate, rather than restriction the present invention, under the prerequisite without prejudice to thinking of the present invention and principle, to inventing any change that indivedual technology step mules carry out or changing and will fall within the scope of the claims in the present invention.
Embodiment 1: Semen Crataegi drying, pulverize, and cross 20 mesh sieves, the alcohol heating reflux through 80% extracts 2 times, after extracting liquid filtering, merges, and is evaporated to extractum shape, dry, obtains Semen Crataegi extract.Radix Arnebiae (Radix Lithospermi) dehydrated alcohol reflux, extract, 3 times, merge after extracting liquid filtering, are evaporated to extractum shape, dry, obtain Radix Arnebiae extract.Get Semen Crataegi extract and Radix Arnebiae extract that weight proportion is 1:3, suitable adjuvant, makes suppository in addition.
Embodiment 2: Semen Crataegi drying, pulverize, and cross 20 mesh sieves, the alcohol heating reflux through 70% extracts 3 times, after extracting liquid filtering, merges, and is evaporated to extractum shape, dry, obtains Semen Crataegi extract.Radix Arnebiae (Radix Lithospermi) is extracted 2 times by ethyl acetate backflow, after extracting liquid filtering, merges, and is evaporated to extractum shape, dry, obtains Radix Arnebiae extract.Get Semen Crataegi extract and Radix Arnebiae extract that weight proportion is 1:5, suitable adjuvant, makes gel in addition.
Embodiment 3: Semen Crataegi drying, pulverize, and cross 20 mesh sieves, the alcohol heating reflux through 95% extracts 3 times, after extracting liquid filtering, merges, and is evaporated to extractum shape, dry, obtains Semen Crataegi extract.Radix Arnebiae (Radix Lithospermi) is extracted 2 times by ethyl acetate backflow, after extracting liquid filtering, merges, and is evaporated to extractum shape, dry, obtains Radix Arnebiae extract.Get Semen Crataegi extract and Radix Arnebiae extract that weight proportion is 2:1, suitable adjuvant in addition,
Claims (8)
1. one kind is used for the treatment of colpitic pharmaceutical composition and preparation method thereof, it is characterized in that pharmaceutical composition is formed by Semen Crataegi extract and Radix Arnebiae extract assembly.
2. pharmaceutical composition according to claim 1, the weight proportion that it is characterized in that Semen Crataegi extract is 1-10 part, the weight proportion of Radix Arnebiae extract is 1-10 part.
3. pharmaceutical composition according to claim 1, the weight proportion that it is characterized in that Semen Crataegi extract and Radix Arnebiae extract is 1:5～5:1.
4. the preparation method of pharmaceutical composition according to claim 1, is characterized in that extraction is solvent extraction method and chromatography with the method for separated Semen Crataegi and Radix Arnebiae extract.
5. the preparation method of pharmaceutical composition according to claim 4, is characterized in that, Semen Crataegi drying is pulverized, cross 20 mesh sieves, through the organic solvent heating and refluxing extraction of 50-80% 2-3 time, after extracting liquid filtering, merge, be evaporated to extractum shape, dry, obtain Semen Crataegi extract.
6. the preparation method of pharmaceutical composition according to claim 4, is characterized in that, the organic solvent reflux, extract, of Radix Arnebiae (Radix Lithospermi) use 50-100% 2-3 time, merges after extracting liquid filtering, is evaporated to extractum shape, dry, obtains Radix Arnebiae extract.
7. according to the preparation method of the pharmaceutical composition described in claim 5 and 6, it is characterized in that, organic solvent used is the mixture of ethanol, methanol, acetone, ethyl acetate or its any several solvents.
8. pharmaceutical composition according to claim 1 and preparation method thereof, is characterized in that, is equipped with appropriate pharmaceutic adjuvant, makes suppository, gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310451034.8A CN103520315A (en) | 2013-09-27 | 2013-09-27 | Medicinal composition for treating gynecological vaginitis and preparation method of medicinal composition |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310451034.8A CN103520315A (en) | 2013-09-27 | 2013-09-27 | Medicinal composition for treating gynecological vaginitis and preparation method of medicinal composition |
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| CN103520315A true CN103520315A (en) | 2014-01-22 |
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| CN201310451034.8A Pending CN103520315A (en) | 2013-09-27 | 2013-09-27 | Medicinal composition for treating gynecological vaginitis and preparation method of medicinal composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308104A (en) * | 2017-06-30 | 2017-11-03 | 江苏耐雀生物工程技术有限公司 | A kind of preparation method of gynecological gel |
| CN114874985A (en) * | 2022-06-16 | 2022-08-09 | 杭州中赢生物医疗科技有限公司 | High-purity high-efficiency amplification method of NK cells |
-
2013
- 2013-09-27 CN CN201310451034.8A patent/CN103520315A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308104A (en) * | 2017-06-30 | 2017-11-03 | 江苏耐雀生物工程技术有限公司 | A kind of preparation method of gynecological gel |
| CN114874985A (en) * | 2022-06-16 | 2022-08-09 | 杭州中赢生物医疗科技有限公司 | High-purity high-efficiency amplification method of NK cells |
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| WD01 | Invention patent application deemed withdrawn after publication | ||
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Application publication date: 20140122 |