CN100488547C - Pharmaceutical composition for treating tinea and complication thereof - Google Patents

Abstract

Disclosed is a pharmaceutical composition for treating tinea and its complications, which comprises Chinese medicinal herbs including cortex pseudolaricis, clove, bletilla striata, motherwort and licorice root, and has the advantages of low cost, short course of treatment, higher curing rate, and low recurrence rate.

Description

The pharmaceutical composition that is used for the treatment of ringworm and complication thereof

One, technical field: the present invention relates to medical technical field, in particular for the pharmaceutical composition of treatment ringworm and complication thereof.

Two, background technology: said composition comprises Chinese medicines such as Cortex Pseudolaricis, Flos Caryophylli, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Leonuri, Radix Glycyrrhizae.

Cortex Pseudolaricis belongs to detoxifcation parasite killing dampness removing to stop itchin class medicine, has good parasite killing and treats tinea, removing dampness itching-relieving action, and external can be controlled the card of eczema, scabies and various skin pruritus; Especially be longer than the treatment tinea, specially control various tinea diseases such as tinea corporis, tinea capitis, the tinea manuum, tinea pedis.To 10 kinds of common pathomycetes of China, the tinea bacterium of particularly causing a disease all has the anti-effect that presses down, 0.1---during 1mg/ml to oidium schoenleinii, acrothesium floccosum, rust tinea bacterium, microsporon gypseum, read ball bacterium etc. in vain bactericidal action arranged; Because of this product oral toxicity is bigger, do not take orally clinically, only do external, in the external process, do not see the clinical report of toxic reaction up till now as yet.

The Genus Syringa Wen Han class medicine that activates yang cures mainly tinea manus and pedis, tinea corporis and cruris, tuberculosis of skin, xerosis cutis, and tubercule bacillus is had the complete inhibition effect, and dermatophytes and other pathogenic bacterium are had certain inhibitory or killing effect.Flos Caryophylli is one of common food flavouring agent.

The Pseudobulbus Bletillae (Rhizoma Bletillae) belongs to hemostasis analgesic therapy class medicine, has the effect of astringing to arrest bleeding, detumescence and promoting granulation, diseases such as treatment of ulcer swells and ache, rhagadia manus et pedis, chilblain, tuberculosis of skin.

Mother wort promoting blood circulation, removing blood stasis and relieving pain class medicine has the effect of clearing heat, releasing toxin, removing swelling, is used for the treatment of diseases such as stasis, amenorrhea, dredge the meridian passage, edema and pain, can be used for sore and toxic again, diseases such as itchy skin eruption, i.e. oral administration, but also external application, washout.

Glycyrrhiza invigorating the spleen and benefiting QI class medicine has coordinating the actions of various ingredients in a prescription, separates the effect of hundred poison of drug, and the poisoning due to some drugs, food, interior metabolism product and the bacteriotoxin thereof is all had certain Detoxication; Modern study: Radix Glycyrrhizae has adrenocortical hormone sample function, coordinates substance metabolism, and enhancing body is to the adaptive capacity of adverse circumstances, and has effects such as antiulcer, antiinflammatory, antitumor, antitussive, blood fat reducing; Oral administration, but also external.

It is known as the compositions of active princlple that application contains Cortex Pseudolaricis, Flos Caryophylli, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Leonuri, Radix Glycyrrhizae, but with Cortex Pseudolaricis, Flos Caryophylli, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Leonuri, Radix Glycyrrhizae compatibility as the compositions of treatment ringworm and complication thereof report as yet.

Ringworm is due to pathomycete infects, the sick skin hyperplasia plumpness of decreasing of clinical manifestation, violent pruritus, so occur swelling and ache, drying chaps incrustation desquamation or complication such as wellability eczema and infection suppurates.As untimely treatment, can decrease because of a certain local disease and infect other position of health, as being passed by tinea pedis is the tinea manuum, tinea manus and pedis passes and is tinea unguium, though threat to life safety does not influence routine work, studying and living because of pruritus swells and ache, and has reduced quality of life and health level, the primary disease prevalence is high and rise treatment back relapse rate height year by year.

The improvement of current antifungal drug research toxic and side effect, remain major subjects, use the hormons medication to the different antagonism of external antifungal medicament active meeting generation degree, abusing antibiotic makes pathomycete produce certain Drug resistance again, it is many and complicated that treatment by Chinese herbs ringworm and complication thereof have active ingredient, and interact, play a role from multipath, too many levels, many target spots, many-side, and cure rate height, relapse rate are low.But the seen on the market treatment ringworm and the medicine of complication have, and a lot of prescriptions are numerous and diverse, the medicine of similar effect repeats in a prescription, cause efficacy exertion bad, the waste resource, what also have can not take into account complication, maybe can not fully recover and prolonged the course of treatment, what also have cures the symptoms, not the disease, and causes after patient's medication just sx and does not heal for a long time; And expense is all somewhat expensive.

Three, summary of the invention: for the shortcoming and defect of the medicine that overcomes existing treatment ringworm and complication thereof, this is bright to provide a kind of compositions, and said composition is principal agent with the Cortex Pseudolaricis, and is all effective at various ringworms treatments; Flos Caryophylli is inferior, and Cortex Pseudolaricis treatment ringworm is played the complementary effect of addition; The effect of the complication that treatment causes by ringworm is played in Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation analgesic therapy; The Herba Leonuri promoting blood circulation, removing blood stasis and relieving pain, dredge the meridian passage, clearing heat, releasing toxin, removing swelling makes the drug effect of respectively distinguishing the flavor of be able to effective performance, and the effect of treatment itchy skin eruption is also arranged; Radix Glycyrrhizae plays coordinating the actions of various ingredients in a prescription, separates hundred poison of drug, separates patient's internal metabolism toxin and bacteriotoxic effect, and its adrenocortical hormone sample function works to promote the performance drug effect to other medicines, and antagonism can not occur, and pathogenic bacterium are developed immunity to drugs.

Because the result of broad research, the inventor has found that Cortex Pseudolaricis, Flos Caryophylli, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Leonuri, the novel combination of Radix Glycyrrhizae, this novel combination have synergism for treatment ringworm and complication thereof, this synergism makes all medicines give full play to effect, shortened the course of treatment, cure rate improves, relapse rate descends, and cost does not improve, and is convenient to clinical using and does not have toxicity.

The invention provides the pharmaceutical composition that is used for the treatment of ringworm and complication thereof, it comprises Cortex Pseudolaricis, Flos Caryophylli, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Leonuri, Radix Glycyrrhizae as active princlple; Respectively distinguishing the flavor of in the compositions, each medical material market is all available at home for medical material, and its extract also has the professional production manufacturer production.

Respectively distinguishing the flavor of Chinese medicine among the present invention can be with its extract as raw material, by the present invention's Chinese medicine extract effective dose of respectively distinguishing the flavor of, in whole crude drug is by weight ratio: Cortex Pseudolaricis 5---30g; Flos Caryophylli 3---20g; The Pseudobulbus Bletillae (Rhizoma Bletillae) 3---20g; Herba Leonuri 3---20g; Radix Glycyrrhizae 5---30g.

Compositions of the present invention can be pressed the dispenser of series preparation form, for example: powder, lotion, unguentum, stick agent, inuncts, mix and prepare with known drug carrier, adjuvant and additive, also can make tablet, powder earlier, add relevant carriers again when using and use, be prepared by usual way.Wherein inuncts and lotion available water and/or vinegar and/or 50---95% ethanol is as carrier, the also available acetic acid of described vinegar, salicylic acid, benzoic acid etc.

Advantage of the present invention is that this compositions has notable therapeutic effect to treatment ringworm and complication thereof, and the compositions each component has good synergism, thereby reduces cost of drugs, cure rate improves, relapse rate descends, and no incompatibility has no adverse reaction and toxic reaction.Sufficient raw.

Four, the specific embodiment:

Relatively tabulate below with reference to embodiment and clinical implementation effect and to be described in detail the present invention:

Embodiment 1: prescription: (by whole crude drug)

Cortex Pseudolaricis 20g;

Flos Caryophylli 10g;

Pseudobulbus Bletillae (Rhizoma Bletillae) 10g;

Herba Leonuri 15g;

Radix Glycyrrhizae 25g;

To add medicine to adds clear water 1500ml immersion 1 hour, and filtered through gauze is used in slow fire boiling 20 minutes, and when treating that temperature is reduced to 40 ℃ of left and right sides, bubble is suffered from hands, the foot of tinea, each 20 minutes, every day 2 times.Filter the reuse of heating next day.

Embodiment 2: fill a prescription with embodiment 1:

Each medicine of prescription is immersed in 48 hours after-filtration among the 75% ethanol 500ml, makes tincture, wipe the affected part every day outward 3 times.

Embodiment 3: fill a prescription with embodiment 1:

Each medicine of prescription is immersed among the 75% ethanol 200ml 48 hours adds the 300ml mature vinegar again, make externally applied liniment after the filtration, every day 3 times.

Embodiment 4: fill a prescription with embodiment 1:

Each medicine of prescription after purifying, with relevant externally used paste carrier (as animal oil, vegetable oil, vaseline etc.) 80g uniform mixing, is made unguentum, and every day, coating was 5 times.

Embodiment 5:

(1) Therapeutic Method: earlier by the administrated method dispenser of embodiment 1, dry the method dispenser of suffering from behind hands, the foot again by embodiment 3.

(2) clinical data: control patient's 50 examples altogether, tinea pedis 43 examples wherein, hands, tinea pedis 3 examples, tinea corporis 4 examples, wherein male 32 examples, women 18 examples, minimum 12 years old of age, maximum 59 years old, average 26 years old; The course of disease is the longest 2 years, and is the shortest 2 months, person's 6 examples that have the suppurative infection concurrently, and all patients all do not have allergies; Most of patients once used all kinds of cream (water) medicine, PIYANPING and hormones ointment to be coated with outward.

(3) criterion of therapeutical effect: recovery from illness; Clinical symptoms and local erythra all disappear, and microscopy fungus feminine gender is embrocated with 0.9% normal saline in the affected part; Produce effects: clinical symptoms and skin lesion obviously improvement reach 70%, and the smear for microscopic examination fungal filament reduces; Take a turn for the better: clinical symptoms and skin lesion make moderate progress and reach 50%, and mycology is checked positive; Invalid: clinical symptoms, sign and fungus are checked no significant change.

3.2 therapeutic effect: see attached list 1:

Subordinate list 1:50 example hands, foot, tinea corporis observation of curative effect statistical table:

Patient's number	Recovery from illness	Produce effects	Take a turn for the better	Invalid	Total effective rate %	Cure rate %
							50 people	41	7	1	1	98％	82％

6 routine suppurative infection persons all fully recover.

The enforcement of this compositions contrast clinical report in the past has notable therapeutic effect as can be seen from the subordinate list of embodiment 5.

Claims (1)

1, a kind of pharmaceutical composition that is used for the treatment of ringworm and complication thereof, it is characterized in that: it is to be made by weight ratio by following raw materials according:

Cortex Pseudolaricis 20g;

Flos Caryophylli 10g;

Pseudobulbus Bletillae (Rhizoma Bletillae) 10g;

Herba Leonuri 15g;

Radix Glycyrrhizae 25g;

1) will add medicine to and add clear water 1500ml and soaked 1 hour, filtered through gauze is used in slow fire boiling 20 minutes;

2) get each medicine of prescription in addition and be immersed among the 75% ethanol 200ml 48 hours and reenter and add the 300ml mature vinegar, make externally applied liniment after the filtration.