CN115227765B

CN115227765B - Preparation and application of uterus warming three-volt patch for treating dysmenorrhea

Info

Publication number: CN115227765B
Application number: CN202210519992.3A
Authority: CN
Inventors: 刘京丽; 王燚杨; 沈春雨; 赵旭; 何玉皎; 陈香梅
Original assignee: Changchun University of Chinese Medicine
Current assignee: Changchun University of Chinese Medicine
Priority date: 2022-05-13
Filing date: 2022-05-13
Publication date: 2023-06-30
Anticipated expiration: 2042-05-13
Also published as: CN115227765A

Abstract

A preparation and application of a uterus warming three-volt patch for treating dysmenorrhea belong to the field of traditional Chinese medicine patches. Preparation: 1. taking morinda officinalis, cinnamon, asarum, nutgrass galingale rhizome, chinese angelica, rhizoma corydalis, mugwort leaf, motherwort and white mustard seed powder, grinding the powder and sieving to obtain raw material powder; 2. mixing the raw material powder with rhizoma Zingiberis recens juice, and making into three-volt patch. Application: the acupoint application is used for cold-dampness stagnation type dysmenorrhea patients; the acupoints applied on the acupoint are Guanyuan, shenque, uterus two sides, secondary liao two sides and Qihai. The invention has very good improvement condition for dysmenorrhea; the external treatment can reduce the pain of patients when taking medicines and eliminate the conflict psychology of patients on medicines. Aiming at cold-dampness stagnation type dysmenorrhea, the invention can treat the cold-dampness stagnation type dysmenorrhea, remove cold in a patient, and strengthen healthy qi of the patient. The yang-warming medicament can regulate yang deficiency type or yin excess type of the patient, and the effect of the medicament is utilized to enhance the qi and blood circulation of the patient, so that the aim of treating or relieving dysmenorrhea is fulfilled. The uterus warming three-volt patch is suitable for treating dysmenorrhea.

Description

Preparation and application of uterus warming three-volt patch for treating dysmenorrhea

Technical Field

The invention belongs to the field of traditional Chinese medicine patches, and particularly relates to a uterus warming three-volt patch for treating dysmenorrhea and application thereof.

Background

Dysmenorrhea is generally divided into primary dysmenorrhea and secondary dysmenorrhea; primary dysmenorrhea usually occurs in young women and pain begins mostly after menstrual onset, with the most severe pain occurring on the first day of menstruation, lasting for 2-3 days of relief. Pain is spasticity, and may be accompanied by symptoms such as nausea, vomiting, diarrhea, dizziness, and hypodynamia. Secondary dysmenorrhea refers to dysmenorrhea occurring years after menstruation, and is commonly seen clinically as endometriosis or adenomyosis.

Dysmenorrhea is often caused by cold congealing in uterus or obstruction of collaterals by blood stasis and unsmooth qi and blood circulation in theory analysis of traditional Chinese medicine. Affecting the normal life and work of females and reducing the quality of life of females. Xin Wenlei Chinese patent medicine and clinical gynecological menstruation regulating and pain relieving medicine are taken through analyzing the cause and symptoms of dysmenorrhea. At present, three-volt patches are also adopted to relieve dysmenorrhea, but the traditional three-volt patches have various medicines, have the effects of activating blood and dissolving stasis, but have the disadvantages of undefined treatment range, unsatisfied compatibility, poor pertinence, easy blind purpose disorder of a patient under the condition of undefined etiology, delayed time, delayed illness state and possible bad stimulation and influence on local skin, so that the patient can be cured early to avoid later-stage harm only by following doctor's advice type differentiation treatment on the cause of disease.

Disclosure of Invention

The invention aims to solve the problems in the prior art and provide a preparation method and application of a uterus warming three-volt patch for treating dysmenorrhea.

The preparation of the uterus warming three-volt patch for treating dysmenorrhea is realized by the following steps:

1. weighing 12-18 parts of morinda officinalis, 7-13 parts of cinnamon, 3-9 parts of asarum, 6-12 parts of nutgrass galingale rhizome, 12-18 parts of Chinese angelica, 12-18 parts of corydalis tuber, 9-15 parts of mugwort leaf, 6-12 parts of motherwort and 0-3 parts of white mustard seed powder, grinding into powder, and sieving to obtain raw material powder;

2. mixing the above raw materials with rhizoma Zingiberis recens juice, mixing, making into medicinal cake, and placing on medical blank non-woven cloth tri-volt patch to obtain the preparation of uterus warming tri-volt patch for treating dysmenorrhea;

the sieving is 100 mesh sieving;

the semen Sinapis Albae powder is not used if patients get blisters;

the dosage of the raw material powder is 12-18 g, and the dosage of the ginger juice is 6-9 g;

the diameter of the medicine cake is 2cm, and the thickness is 1.5-2 mm.

The application of the uterus warming tri-volt patch for treating dysmenorrhea is applied to acupoint application of cold-dampness stagnation type dysmenorrhea patients;

the acupoints applied by the acupoints are Guanyuan, shenque, uterus bilateral, secondary liao bilateral and Qihai;

the time and the course of the acupoint application are as follows: the plaster is applied for 8 to 10 hours for 1 time every 10 days in the first three days after the initial volt, the middle volt, the final volt and the volt in summer.

The uterus warming three-volt patch for treating dysmenorrhea is used for cold-dampness stagnation type dysmenorrhea patients, and has good improvement condition and curative effect on dysmenorrhea. According to the invention, through analyzing the cause and symptoms of dysmenorrhea, the pungent and warm drugs and clinical gynecological menstruation-regulating and pain-relieving commonly used drugs (morinda officinalis, corydalis tuber, asarum, cinnamon, nutgrass galingale rhizome, chinese angelica, white mustard seed, mugwort leaf and motherwort) are adopted to promote the blood circulation of the air, and the vital energy of a human body is stimulated, so that the aim of treating female cold-dampness stagnation type dysmenorrhea is fulfilled. The prescription of the three-volt patch for warming uterus is mainly pungent and warm medicines for dispelling cold evil and running meridians and Wen Liqu evil; the herbs such as Xiang Fu, yi mu Cao and ai Ye are commonly used in gynecology, and the combination of all herbs has the actions of warming meridians and alleviating pain.

The invention relates to a uterus warming Sanfu plaster for treating dysmenorrhea, which has the mechanism of activating vital qi of a human body, regulating physique of a patient, stimulating acupoints through transdermal drug effect and activating corresponding systems of the whole body, thereby regulating yin and yang of the human body, strengthening vital qi and eliminating evil. The external therapy can reduce the pain of patients when taking medicines, eliminate the contradiction of the patients to medicines, and utilize the principle of combining people and people, and regulate the constitution of cold-dampness stagnation type dysmenorrhea patients according to the principle of nourishing yang in spring and summer in the time of most abundant yang qi in three-volt days and treat the condition of cold evil and blood stasis in the body. Aiming at cold-dampness stagnation type dysmenorrhea, the invention can treat the cold-dampness stagnation type dysmenorrhea, remove cold in a patient, and strengthen healthy qi of the patient. The yang-warming medicament is used for regulating yang-deficiency type or yin-excess type body quality of a patient, and the effect of the medicament is utilized for enhancing qi and blood circulation in the patient, so that the internal evil of healthy qi can not be dried during menstruation or before and after menstruation of women, thereby achieving the purpose of treating or relieving dysmenorrhea.

The uterus warming three-volt patch is suitable for treating dysmenorrhea.

Drawings

FIG. 1 is a bar graph comparing the total effective rates of the treatment group and the control group in the examples.

Detailed Description

The technical scheme of the invention is not limited to the specific embodiments listed below, and also includes any combination of the specific embodiments.

The first embodiment is as follows: the preparation method of the uterus warming tri-volt patch for treating dysmenorrhea is realized by the following steps:

2. mixing the above raw materials with rhizoma Zingiberis recens juice, mixing, making into medicinal cake, and placing on medical blank non-woven cloth tri-volt patch to obtain the final product for treating dysmenorrhea.

The second embodiment is as follows: the first difference between this embodiment and the specific embodiment is that 14 parts of morinda officinalis, 8 parts of cinnamon, 5 parts of asarum, 8 parts of nutgrass galingale rhizome, 16 parts of Chinese angelica, 15 parts of corydalis tuber, 13 parts of mugwort leaf, 11 parts of motherwort and 3 parts of white mustard seed powder are weighed. Other steps and parameters are the same as in the first embodiment.

And a third specific embodiment: the present embodiment differs from the first or second embodiment in that 16 parts of morinda officinalis, 12 parts of cinnamon, 7 parts of asarum, 10 parts of nutgrass galingale rhizome, 15 parts of Chinese angelica, 16 parts of corydalis tuber, 14 parts of mugwort leaf and 10 parts of motherwort are weighed. Other steps and parameters are the same as in the first or second embodiment.

The specific embodiment IV is as follows: this embodiment differs from one to three embodiments in that the sieving in step one is a 100 mesh sieve. Other steps and parameters are the same as in one to three embodiments.

Fifth embodiment: this embodiment differs from one to four embodiments in that the white mustard seed powder described in step one is not used if the patient has blisters. Other steps and parameters are the same as in one to four embodiments.

Specific embodiment six: the difference between the present embodiment and the first to fifth embodiments is that the raw material powder in the second step is 12-18 g, and the ginger juice is 6-9 g. Other steps and parameters are the same as in one of the first to fifth embodiments.

Seventh embodiment: the difference between the present embodiment and the first to sixth embodiments is that the diameter of the medicine cake in the second step is 2cm and the thickness is 1.5-2 mm. Other steps and parameters are the same as in one of the first to sixth embodiments.

Eighth embodiment: the application of the uterus warming tri-volt patch for treating dysmenorrhea in the embodiment is applied to acupoint application of cold-dampness stagnation type dysmenorrhea patients.

Detailed description nine: the eighth difference between the present embodiment and the specific embodiment is that the acupoints applied by the acupoints are Guanyuan, shenque, two sides of uterus, two sides of secondary liao and Qihai. Other steps and parameters are the same as in embodiment eight.

Detailed description ten: the eighth and ninth embodiments are different from the eighth and ninth embodiments in that the time and the course of treatment of the acupoint application are as follows: the plaster is applied for 8 to 10 hours for 1 time every 10 days in the first three days after the initial volt, the middle volt, the final volt and the volt in summer. Other steps and parameters are the same as in embodiments eight and nine.

The beneficial effects of the invention are verified by the following examples:

examples:

1. weighing 14 parts of morinda officinalis, 8 parts of cinnamon, 5 parts of asarum, 8 parts of nutgrass galingale rhizome, 16 parts of Chinese angelica, 15 parts of corydalis tuber, 13 parts of mugwort leaf, 11 parts of motherwort and 3 parts of white mustard seed powder, grinding into powder and sieving to obtain raw material powder;

The screening in step one of this example is a 100 mesh screen.

In the first embodiment, if the patient is blistered, the white mustard seed powder is not used.

In the second embodiment, the amount of the raw material powder is 16g, and the amount of the ginger juice is 8g.

In the second step of this embodiment, the diameter of the medicine cake is 2cm, and the thickness is 2mm.

The application of the uterus warming three-volt patch for treating dysmenorrhea is applied to acupoint application of cold-dampness stagnation type dysmenorrhea patients.

The acupoints applied by the acupoint application are Guanyuan, shenque, uterus bilateral, secondary liao bilateral and Qihai; the specific corresponding application part of the acupoint: the center of the three-volt patch for warming uterus for treating dysmenorrhea in this example was aligned with the umbilical region (Shenque), 1.5-2.5cm below the umbilical region (Qihai), 3-4cm below the umbilical region (Guanyuan), two sides of the lower abdomen, 4-5cm below the umbilical region, 3-4cm beside the midline (uterus bilateral), two sides of the sacrum region, and 1-2cm beside the midpoint of the sacrum (Suliao bilateral).

The time and course of application of the acupoints in this embodiment: the plaster is applied for 8 hours 1 time every 10 days in the first three days after the first, middle, last and last volt of summer.

1. And (3) clinical effect verification:

1. clinical method

A random grouping control method is adopted, cold-dampness stagnation type dysmenorrhea patients in universities and colleges of universities and peripheral higher schools of vinca traditional Chinese medicine are taken as study objects, after qualified subjects are determined according to diagnosis standards, inclusion standards and exclusion standards, subject informed consent books are signed, and 60 patients are randomly divided into a treatment group and a control group, wherein 30 patients are in each group. The treatment group is treated by self-made uterus warming three-volt plaster, 1 period is 1 treatment course, and the treatment effect is counted after 1 treatment course. The control group is treated by applying dysmenorrhea, the treatment time is from three days before each menstruation to the third day of menstruation, 1 time is applied every two days, 1 treatment course is treated for 4 times each menstruation, and the statistical curative effect is obtained after 3 continuous treatment courses. Referring to the guidelines of clinical study of new Chinese medicine, the improvement condition and curative effect of dysmenorrhea of patients are detected by changing symptoms before and after treatment of the patients in treatment groups and control groups.

2. Basic condition of patient

Patients included in the clinical study ranged from 18 to 25 years of age, with the average age of the treatment group being 20.967 + -1.99 years and the average age of the control group being 21.100 + -2.264 years. According to normal analysis, the two groups of patients were compared with independent sample t-test without statistical difference (P > 0.05), and the ages of the two groups of subjects were confirmed to be comparable, as shown in Table 1.

Table 1 age comparison of two groups of patients (x.+ -. S)

Group of	Number of examples	Minimum age (age)	Maximum age (age)	Average age (age)
					Treatment group	30	18	25	20.967±1.991
Control group	30	18	26	21.100±2.264

Note that: through t test, t= -0.242, p=0.477 > 0.05, and the two groups of patients have no significant difference in age.

3. Efficacy comparison

Analysis and comparison of treatment results for two groups of subjects by non-parametric test: the z value is-2.306, and the p value is 0.021, so that the clinical efficacy of the treatment group and the control group is statistically significant (p < 0.05). The total effective rate of the treatment group is 93.33 percent; the total effective rate of the control group is 76.67%. There is therefore a clear difference in clinical effect, and this analysis demonstrates: the treatment group had better efficacy, see table 2 and figure 1.

Table 2 comparison of total efficacy of two groups after treatment

Group of	Number of examples	Healing	Has obvious effect	Effective and effective	Invalidation of	Total effective rate
							Treatment group	30	5	16	7	2	93.33％
Control group	30	1	13	9	7	76.67％

Note that: the two groups of non-parametric tests show that Z= -2.306, P=0.021 <0.05, and the difference is statistically significant.

2. Pharmacodynamic study

Dysmenorrhea is often caused by cold congealing in uterus or obstruction of collaterals by blood stasis and unsmooth qi and blood circulation in theory analysis of traditional Chinese medicine. Affecting the normal life and work of females and reducing the quality of life of females. According to the analysis of the cause and symptoms of dysmenorrhea, the pungent and warm drugs and clinical gynecological menstruation-regulating and pain-relieving commonly used drugs (morinda officinalis, corydalis tuber, asarum, cinnamon, nutgrass galingale rhizome, chinese angelica, white mustard seed, mugwort leaf and motherwort) are adopted in the embodiment to promote the blood circulation and excite the human body to regulate vital qi, so that the aim of treating female cold-dampness stagnation type dysmenorrhea is fulfilled. The formula of the three-volt patch for warming uterus is mainly pungent and warm drugs for dispelling cold evil and running meridians and Wen Liqu evil; the herbs such as Xiang Fu, yi mu Cao and ai Ye are commonly used in gynecology, and the combination of all herbs has the actions of warming meridians and alleviating pain. The following will analyze the efficacy of drugs from the viewpoint of drug selection, efficacy of traditional Chinese medicines and modern pharmacological research.

1. Drug selection

Regarding to the symptoms of dysmenorrhea, metrorrhagia and metrostaxis and the like of women, in the treatment of the symptoms related to female menstruation, the use frequency of traditional Chinese medicine four-qi and warm-nature medicines is highest; in clinic, the medicines such as angelica, cinnamon and the like for treating gynecological related diseases have the highest use frequency.

2. Drug analysis

(1) Semen Sinapis Albae

New modified Ben Cao (Su Jing et al, new modified Ben Cao [ M ]. Shanghai: shanghai science and technology Press, 1957.) records that mustard is pungent in taste, warm in nature and nontoxic. Enter nose. Mainly remove kidney pathogenic qi, promote nine orifices, improve the eyes and ears, calm the middle warmer, and warm the middle warmer after long-term administration. The mustard has three kinds, one of which is white mustard, coarse white, such as white rice, even Xin Mei, from the armywork. Bai Ji Zhi belongs to the herb with warm nature, and it can remove cold accumulation in warm nature. The description of the Chinese patent publication of "Ben Cai Ji" (Qing. Zhang Bingcheng, editions of Ben Cai Ji M.,. Shanghai: shanghai health Press.1958.): bai Ji Zhi can induce sweat. The heat can warm the middle. To widen the chest and diaphragm and promote qi. But can dispel cold and consume nutrient yin. According to the related literature, semen brassicae can circulate and enter lung meridian, and most of the diseases such as asthma and phlegm are clinically treated. Because of its pungent and warm nature and flavor, it has the action of dispersing (Wang Shuangshuang, zheng Guoyin, qing Zhao, ji Zhao, an experimental study on the application of the acupoint of Sinapis Albae to inhibit the growth of transplanted tumor of liver cancer H22 [ J ]. The Chinese and Western medicine is combined with liver disease journal 2021 (03)), it can walk in the meridians and collaterals to warm their meridians and dissipate nodulation to achieve the effects of dredging collaterals and relieving pain. Modern pharmacological research shows that white mustard seed has the functions of anti-inflammatory and analgesic, and the analgesic effect of Western medicine is equivalent to the analgesic effect of traditional medicine. Li Xiaoli (Li Xiaoli, zhang Yingqing, huang Tonghua. Research on anti-inflammatory and analgesic effects of semen Sinapis Albae extract [ J ]. Modern Chinese medicinal research and practice, 2007,21 (6): 28-30.) has shown by animal experimental study that semen Sinapis Albae significantly inhibits increase in capillary permeability of mice; meanwhile, the time of the pain reaction of the mice is prolonged, the number of times of twisting the mice is reduced, and the experiment proves the anti-inflammatory and analgesic effects of the white mustard seeds.

(2) Herba asari

Shen nong Ben Cao Jing (Shen nong's herbal), asarum, pungent in flavor and warm in nature. Cough with dyspnea, headache, brain movement, contracture of hundred joints, arthralgia due to wind-dampness and pain. It is taken for a long time to improve eyesight, promote nine orifices, and lighten body for a long time. Among four qi and five flavors, pungent herbs have the property of moving, moving in the meridians, and asarum enters the shaoyin meridians, with the effect of inducing resuscitation, and the moon is derived from uterus, which is closely related to kidneys. The research of Chinese medicine shows that asarum has the functions of relieving exterior syndrome, dispelling cold, dispelling wind, inducing resuscitation, relieving pain, warming lung and resolving fluid retention, and is commonly used for treating wind-cold exterior syndrome, wind-cold dampness pain, nasal obstruction and other symptoms in clinical prescription. Continuous researches by medical doctors prove that asarum also has the effects of warming meridians and activating blood. From the traditional medical point of view, asarum has the effect of inducing resuscitation and is effective in treating the channels of the shaoyin, kidneys belong to the shaoyin, and women eat for a month to get damp and associated with the shaoyin. Modern pharmacological researches have shown that asarum has the effects of relieving pain, resisting inflammation, relieving asthma and cough, and the like, and also has the activities of resisting virus, resisting bacteria, calming, resisting oxidation, resisting depression, reducing blood pressure, inhibiting cancer cells, and the like (Wu, wen Xiaoyin, yan Peng, and the like; the research progress of the chemical components and the pharmacological actions of asarum [ J ]. The journal of Chinese experimental prescription science, 2021,27 (04): 186-195).

(3) Rhizoma corydalis

The description of "hai medicine herbal" is about corydalis tuber: the kidney qi is used for treating lochia and infant pillow after rupture, and is combined with rhizoma sparganii, carapax Trionycis and rheum officinale for dispersing qi and dredging channels and collaterals. Yan Hu Huo is a blood-activating and pain-relieving herb, and is indicated for postpartum lochia with blood stasis and women with uncomfortable abdominal pain.

In modern pharmacopoeia, yan Hu Suoju has the functions of activating blood, promoting qi circulation and relieving pain. In clinic, it can be used for treating pain in chest and hypochondrium, epigastrium and abdomen, or chest pain due to blood stasis, amenorrhea dysmenorrhea, postpartum blood stasis, and traumatic injury. In the traditional Chinese medicine, pain is not clear, blood stasis blocks uterus, and female menstrual period qi and blood circulation is not smooth, so that the lower abdomen is painful. The "Kaibao Bencao" describes: corydalis tuber, rhizoma corydalis, pungent taste, warm nature and no toxicity. The main causes are blood breaking, blood of various causes after delivery, irregular menstruation, agglomeration in abdomen, metrorrhagia, postpartum blood dizziness, blood burst up, blood loss due to blood fall, or alcohol consumption and decoction. The book Ben Cao Meng Gan (herbal Meng's tissue fridge) is recorded in Yan Hu, regulates the blood stasis and blood coagulation of the moon water, and stops the postpartum blood flushing and blood dizziness. It is also indicated for traumatic injury with bleeding, stranguria with metrorrhagia, apoplexy and pain, and abdominal pain. In clinical application of traditional Chinese medicine, corydalis tuber is an essential herb for relieving pain. According to modern researches, tetrahydropalmatine, which is the racemic tetrahydropalmatine, in corydalis is the main analgesic substance, wherein the analgesic effect of the levorotatory body is stronger than that of the dextrorotatory body, and the researches show that the analgesic degree of tetrahydropalmatine can reach 40% of that of morphine (analgesic) (Tang Yifeng. The research on chemical components and pharmacological actions of corydalis [ J ]. The clinical research of traditional Chinese medicine, 2018,10 (23): 144-146.).

(4) Chinese angelica

The angelica is a dried root of angelica of the family golden, belongs to one of Chinese herbal medicines with higher application frequency in clinic, belongs to perennial herbaceous plants, has sweet and Wen Xin taste, is returned to heart, spleen, liver and channel, and has the effects of enriching blood, activating blood, resisting inflammation, resisting tumor, regulating menstruation, relieving pain, enhancing immunity and the like. Chinese angelica is firstly recorded in Shen nong Ben Cao Jing, and is considered to have the effect of tonifying five viscera and promoting tissue regeneration, and is considered to be blood replenishing holy medicine after that. In view of the effects of angelica, researchers have carried out numerous researches on the pharmacological actions of the angelica, and the pharmacological actions of the angelica mainly comprise anti-inflammatory, hematopoietic function promoting, anti-tumor liver and kidney protecting, immunity enhancing, cardiovascular and cerebrovascular regulating, uterine smooth muscle relieving asthma and the like. Hu Huijuan (Hu Huijuan, hangzhou madder, wang Pengshu. Anti-inflammatory action of Angelica sinensis [ J ]. J. Chinese traditional medicine, 1991.166111.684-686.704) experiments on mice have found that Angelica sinensis has significant inhibitory effects on both acute and chronic inflammation, and the anti-inflammatory mechanism mainly involves reducing capillary permeability and inhibiting PGE2 synthesis or release.

(5) Cinnamon bark

Cinnamon is pungent, sweet and hot in nature, and enters kidney, spleen, heart and liver meridians. The effects of tonifying fire and invigorating yang, inducing the fire and returning to the origin, dispelling cold and relieving pain, and activating blood and dredging channels; cinnamon is used for treating impotence, cold womb, cold pain in waist and knees, asthma due to kidney deficiency, dizziness due to yang deficiency, conjunctival congestion and pharyngalgia, cold pain in heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, running dolphin, amenorrhea, dysmenorrhea, etc. (Zhang Mingfa, shen Yaqin. Pharmacologic action of cinnamon and efficacy of warming interior [ J ]. Shanxi Chinese medicine, 1995, 16 (1): 39-42.). In modern researches, antibacterial activity screening is carried out on different extraction parts of cinnamon by steam distillation through a filter paper sheet method, antibacterial active parts are optimally extracted by adopting single factor and uniform design, and meanwhile, multi-component HPLC quantitative analysis is carried out on the antibacterial active parts. The result is that the cinnamon antibacterial active site is cinnamon essential oil, and the conclusion is that the cinnamon essential oil has antibacterial activity (Weng Zong, li Zi, sun Qin, etc. the cinnamon antibacterial active site extraction process is optimized, and HPLC quantitative research [ J ]. Sub-traditional medicine 2020 (12): 59-62.). The water extract and ether extract of cinnamon were observed to have significant protective effect on 4 experimental gastric ulcer models, significant antagonistic effect on diarrhea in mice caused by both drugs, significant cholagogic effect on anesthetized rats, and significant analgesic effect, and were the pharmacological basis for the warming middle-jiao and analgesic effect of cinnamon (Zhu Ziping, zhang Mingfa, shen Yaqin, etc. the pharmacological study of warming and stopping pain of cinnamon [ J ] J Chinese J.Chinese J.traditional Chinese medicine, 1999, 18 (9): 553-557.). Modern connotation of cinnamon in warming middle energizer and dispelling cold: i.e. antiulcer, promoting bile secretion, regulating intestinal motility and anti-diarrhea (Zhang Mingfa, shen Yaqin. Pharmacological research of "Wenzhong Mi Miao Han" by Miao Yao [ J ]. J.Chinese J.Zhongmedical information, 2000,7 (2): 30-32.). The anti-inflammatory action is the mechanism of warming the middle-jiao to arrest diarrhea.

(6) Rhizoma Cyperi

The nutgrass galingale rhizome is the dried rhizome of perennial herb nutgrass galingale rhizome of the family Cyperaceae, is pungent, slightly bitter, slightly sweet, flat, returns liver and triple energizer meridian, has the effects of soothing liver and regulating qi, regulating menstruation and relieving pain (Ruan Jinlan, du Junrong, zeng Qingzhong, and the like). In modern researches, in order to determine the effective part of nutgrass galingale rhizome for treating dysmenorrhea, the influence on a model of mice dysmenorrhea caused by oxytocin is observed by observing the separated extraction part of a nutgrass galingale rhizome organic solvent system, and as a result, petroleum ether and ethyl acetate parts of nutgrass galingale rhizome can obviously reduce the number of times of twisting the mice caused by oxytocin, and have extremely significant or significant difference compared with the model. The conclusion is that the petroleum ether and ethyl acetate parts are effective parts for treating dysmenorrhea (Xia Houlin, wu Xi, dong Min, etc. the effects of different solvent extracts of nutgrass galingale rhizome on dysmenorrhea model [ J ]. Shizhen national medicine, 2006,17 (5): 773-774.). In order to compare the influence of different processing methods on the main pharmacological actions of nutgrass galingale rhizome, the water extract of vinegar nutgrass galingale rhizome, wine nutgrass galingale rhizome and raw nutgrass galingale rhizome and blank control Rockwell liquid are used for influencing the in-vivo uterine smooth muscle contraction intensity, frequency and a rat dysmenorrhea model caused by hysterin of female non-pregnant rats. The experimental result shows that the vinegar nutgrass galingale rhizome has stronger inhibition effect on the uterine contraction of rats, the uterine muscle tension is reduced, the contraction force is weakened (Sun Xiumei, zhang Zhaowang, cheng Yanqin, and the like).

(7) Mugwort leaf

Mugwort leaf is a medicinal material with long application history and very wide application range in China. Moxa is recorded as early as in poem: "Extra, it is not seen for one day, for example, three years old. "ancient ballad also has: "Wuyue five days at noon, tianshi ride Ai Hu, cut hundred evil, ghost and charm into the mouth of the tiger. In the formula of fifty-two diseases, there is recorded the therapy of moxa fumigation and moxibustion. The description of Ben Cao gang mu: the Chinese mugwort leaves are slightly bitter and too pungent, and the cooked Chinese mugwort leaves are slightly bitter and too raw Wen Shoure and pure yang. The true fire of the sun can be taken, and the primordial yang can be recovered. The three yin-fluids are taken, and all cold-dampness is removed and the qi to be purified is changed into a fusion. The ancient to date, the literature of the traditional Chinese medicine is related to the moxa, and the Chinese medicine is popular with various doctors for thousands of years. The Chinese medicine considers that the mugwort leaves are pungent, bitter and warm, enter liver, spleen and kidney channels, have the effects of warming channels to stop bleeding, dispelling cold to stop pain, regulating menstruation and preventing miscarriage, are one of the essential drugs for stopping bleeding, and are the common drugs for gynaecology of traditional Chinese medicine. The traditional Chinese medicine clinical symptoms of the mugwort leaf are mainly used for treating irregular menstruation, lower abdomen crymodynia, congealing cold channels, miscarriage prevention, insect disinfestation, itching relief and the like; vinegar Ai Tanwen is used for internal administration or external application by stopping bleeding due to cold; the mugwort leaf can be used for moxibustion, oral administration or fumigation and washing (Hong Zong, ai Jiuhu source [ J ]. University of south and China university (Nature science edition), 2014,33 (4): 47-51). In the general procedure of Jin, the gel Ai Shangzhi has the symptoms of blood deficiency, cold stagnation and menorrhagia; "Shengji general records" Zhongxiang Ai Wanzhi dysentery and pain relieving; ai Jiangshang in the formula of Shi Yi De Fang can treat dysentery with purulent blood; in ai Fu Warm pill (ai Fu Warm pill) in Sheng Shu Shen Shi, it can treat excessive cold due to yang deficiency and malnutrition of Chong and ren meridians. Modern clinical researches on mugwort leaves show that mugwort leaves have wide physiological activities, mugwort leaf oil has the effects of relieving cough, eliminating phlegm and resisting anaphylactic shock, can resist myocardial contraction caused by epinephrine and histamine, achieves the purpose of reducing heart contractility, has a certain effect on a central nervous system, and has strong biological activity, namely triterpenes of mugwort leaves are compounds with anti-inflammatory and liver-protecting activities, and have the effects of resisting bacteria, resisting viruses, resisting swelling and pain, reducing blood pressure and cholesterol and regulating immunity. The folium artemisiae argyi contains flavonoid substances, and has better effects of resisting tumor, reducing cholesterol, reducing blood fat, reducing blood pressure, resisting inflammation, regulating immunity, resisting lipid peroxidation, resisting exterior aging, resisting bacteria, resisting oxidation, promoting blood circulation to remove blood stasis, relieving swelling and pain, inhibiting immunity and the like. Tannins of mugwort leaf play an important role in hemostasis in pharmacological action (Zhang Yuan. Herbal examination of mugwort leaf and application research progress. Shanghai journal of acupuncture 2017,3 (36) 3.) and also have anticancer, anti-tumor, antiallergic, antimutagenic, microorganism inhibiting and antiaging effects.

(8) Motherwort herb

Herba Leonuri is a Labiatae plant, has pungent taste and slightly cold nature, can be used as medicine for treating liver, pericardium and bladder channels, and has effects of promoting blood circulation for removing blood stasis, promoting diuresis, regulating menstruation, and clearing heat and toxic substances. Motherwort has long history of use as a traditional Chinese medicine and is recorded in the literature of the traditional Chinese medicine. The traditional Chinese medicine composition is mainly used for treating gynecological diseases such as menstrual disorder, dysmenorrhea, amenorrhea and the like, is widely applied to postpartum body adjustment, and can effectively improve the conditions of postpartum lochiorrhea and the like of pregnant women. Qing dynasty Chen Shangduo "Bencao Xin Ji Sheng" is: it can be used for both prenatal and postnatal, and has the most effective actions of removing dead fetus, removing blood stasis and promoting tissue regeneration, and also can promote lactation. The name of the Chinese medicine is beneficial to women. Along with the development of the modern pharmaceutical preparation technology, besides the traditional Chinese medicine decoction pieces, the motherwort is also developed into various modern Chinese medicine preparations such as injection granules, capsules and the like for wide application.

Clinical application research of leonurus (Feng Qun, zhao Gong, sun Rong. Clinical application of leonurus and adverse reaction research progress-Chinese drug alert. 2014.2:0074-03) progress as follows:

(1) the 'materia medica outline' cloud: "motherwort herb, herba Leonuri, has the effects of promoting blood circulation and nourishing blood, promoting blood circulation without damaging new blood, nourishing blood without stagnation of blood stasis, and is a holy medicine for blood families. The traditional Chinese medicine considers that the motherwort has the effects of activating blood, removing stasis, regulating menstruation and eliminating water, and is widely used in various aspects of gynecology, in particular in obstetrics. Is one of the common drugs for irregular menstruation, dystocia, and puerperal blood volume. The motherwort has better curative effects on treating gynecological diseases such as postpartum hemorrhage, primary dysmenorrhea, functional uterine bleeding, migraine in menstrual period, lochia after medical abortion, benign lesions of the uterine organs, postpartum dyscrasia and the like (Fan Meihua, wang Jianxin, li, and the like; the research of motherwort is progressed in China-medicine and clinic 2006.67:528-530). The motherwort can maintain uterine contraction time and plays an important role in the treatment of gynecological uterine diseases.

(2) Modern pharmacological researches of motherwort show that it has wide curative effect and application prospect in immune system related diseases. Leonurus herb is pungent in flavor and wind can be dispersed, blood can be activated, blood can be moved to expel wind, wind can relieve itching and self-remove, so that the pathogenic factors are removed, the skin is nourished, and the disease is healed. The prescription using motherwort as main medicine has definite curative effect on immunological infertility, allergic purpura, children purpura nephritis, skin diseases caused by excessive sunlight ultraviolet irradiation, urticaria and other immunological diseases (She Guanyu, chen Ying, liuyu. Immunoregulation action of motherwort and application research progress [ J ]. Medical review, 2011,17 (19): 2996-2998.). The modern pharmacological research shows that the effective components of the leonurus polysaccharide, the diterpene and the like can improve and enhance the lymphatic circulation through the cellular immunity and the humoral immunity, improve the normal organism immunity and promote the pathological state to be returned.

(9) Radix Morindae officinalis

Morinda officinalis, radix Morindae officinalis, has sweet and pungent taste and slightly warm nature, enters kidney and liver meridians, and has the effects of tonifying kidney yang, strengthening tendons and bones, dispelling wind-dampness and the like clinically. Shennong Ben Cao Jing (Shennong's herbal medicine book): the pathogenic qi is not raised, the muscles and bones are strengthened, the five viscera are calmed, the middle warmer is reinforced, the mind is enhanced, and the qi is benefited. It is commonly used in clinic for treating symptoms related to kidney-yang deficiency, such as impotence, spermatorrhea, cold womb, infertility, and cold pain of lower abdomen during menstrual period (Fangxinyi, miao Runyu, wang Han. Tong Xiaolin uses curculigo rhizome, epimedium herb, morinda officinalis, jilin Chinese medicine, 2021,41 (2): 173-175). Pharmacological research in modern medicine shows that morinda officinalis is an important marker for effectively intervening energy metabolism and kidney injury, so that the health physiological condition and metabolic condition of kidney-yang deficiency type white rats can be reversed. The kidney yang deficiency syndrome is the disease name syndrome of the traditional Chinese medicine, is mainly caused by insufficient secretion of cortisol hormone caused by hypothalamus-pituitary-adrenal cortex axis disorder in the research of modern medicine, and the morinda officinalis can effectively improve the cortisol level in vivo. Cold-accumulation abdominal pain type dysmenorrhea is mostly caused by kidney-yang deficiency, yang-qi deficiency, qi and blood failing to warm up, and coagulation and stasis in uterus, thus leading to menstrual abdominal pain. Therefore, the morinda officinalis has definite curative effect on treating cold-dampness stagnation type dysmenorrhea.

In summary, dysmenorrhea is a common disease that afflicts the work and life of women, and occurs before and after menstrual cycles of women of childbearing age, and serious people are accompanied with other symptoms. The three-volt patch is clinically applied, and has the mechanism of activating vital qi of a human body, regulating physique of a patient, stimulating acupoints through transdermal drug effect, activating corresponding systems of the whole body, regulating yin and yang of the human body, strengthening vital qi and eliminating pathogenic factors. The external therapy can reduce the pain of patients when taking medicines, eliminate the resistance psychology of the patients to the medicines, and utilize the principle of the combination of people and people, and regulate the physique of cold-dampness stagnation type dysmenorrhea patients according to the principle of nourishing yang in spring and summer in the time of most abundant yang qi in three-volt days and treat the condition that cold evil and blood stasis exist in the body. Traditional Chinese medicine students always seek treatment methods through methods of disease pathogenesis, diagnosis and treatment based on syndrome differentiation and the like. By combining the discussion of the medicinal effects, the embodiment selects the pair-reason treatment aiming at cold-dampness stagnation type dysmenorrhea, can remove cold in a patient, and supports healthy qi of the patient. By warming yang, the yang deficiency type or yin excess type of the patient is regulated, and the effect of the medicine is utilized to enhance the qi and blood circulation of the patient, so that women can not dry the vital qi and the internal evil before and after menstrual period, thereby achieving the purpose of treating or relieving dysmenorrhea.

Claims

1. The preparation method of the uterus warming three-volt patch for treating dysmenorrhea is characterized by comprising the following steps of:

the diameter of the medicine cake in the second step is 2cm, and the thickness of the medicine cake is 1.5-2 mm.

2. The preparation method of the uterus warming three-volt patch for treating dysmenorrhea according to claim 1, wherein 14 parts of morinda officinalis, 8 parts of cinnamon, 5 parts of asarum, 8 parts of nutgrass galingale rhizome, 16 parts of Chinese angelica, 15 parts of corydalis tuber, 13 parts of mugwort leaf, 11 parts of motherwort and 3 parts of white mustard seed powder are weighed.

3. The preparation method of the uterus warming three-volt patch for treating dysmenorrhea according to claim 1, wherein 16 parts of morinda officinalis, 12 parts of cinnamon, 7 parts of asarum, 10 parts of nutgrass galingale rhizome, 15 parts of Chinese angelica, 16 parts of corydalis tuber, 14 parts of mugwort leaf and 10 parts of motherwort are weighed.

4. The method for preparing a uterine warming tri-voltaic patch for treating dysmenorrhea of claim 1, wherein in step one said sieving is a 100 mesh sieve.

5. The preparation method of the uterus warming three-volt patch for treating dysmenorrhea, which is characterized in that in the second step, the raw material powder is used in an amount of 12-18 g, and the ginger juice is used in an amount of 6-9 g.