CN101711842B - Efficient pure Chinese medicinal anti-inflammation and itching-relieving liquid, and preparation method thereof - Google Patents

Abstract

The present invention relates to a Chinese medicinal preparation for external use, in particular to a pure Chinese medicinal anti-inflammation and itching-relieving liquid, which is mainly extracted and prepared from the following raw materials in part by weight: 15 to 50 parts of lightyellow sophora root, 10 to 40 parts of cortex dictamni, 10 to 40 parts of radix stemonae, 5 to 35 parts of ledebouriella seseloides, 5 to 35 parts of caltrop and 10 to 50 parts of concha haliotidis. The efficient pure Chinese medicinal anti-inflammation and itching-relieving liquid is based on the principle of dispelling pathogenic wind, removing dampness, sterilizing and relieving itching, and has the characteristics of scientific and rational Chinese medicinal formula, unique and advanced preparation process, capability of safely and efficiently treating skin itch caused by a variety of causes, simple using method, good anti-inflammation and itching-relieving effects, precise curative effect, safety and non-toxicity without greasing skin, contaminating clothes or peculiar smell.

Description

A kind of pure Chinese medicine anti-inflammation and itching-relieving liquid and method for making thereof

Technical field

The present invention relates to Chinese medicine for outer use, the particularly a kind of pure Chinese medicine that can treat skin pruritus; The invention still further relates to the method for making of Chinese medicine in addition.

Background technology

Skin pruritus is to betide skin and cause a kind of subjective symptoms of scratching, and is a kind of commonly encountered diseases and the frequently-occurring disease of department of dermatologry.The various skin disease all can cause skin pruritus, skin pruritus that causes as eczema, rubella, urticaria, various dermatitis, tinea manus and pedis, beriberi, scabies, senile sebaceous gland hypofunction and winter climate drying etc., many general systemic diseases are also often with the skin pruritus symptom, as diabetes, uremia, internal tumor, liver and gall diseases and some nervous system disease etc.Motherland's medical science thinks that the pathogenesis of primary disease is the damp and hot heresies of diseases caused by exogenous pathogenic factor, or eating and drinking without temperance, gives birth in damp and hot and accumulates in skin, must not lead off and causes; Or the old constitution weakness, blood-deficiency leading to hyperactivity of the liver, living dry humorously, cause failure of skin and muscle to be nourished to form.

Though cause that the cause of disease of skin pruritus is varied, clinical manifestation all is that pruritus is hard to bear, have also with exudative pimple, eczema with the skin lesions such as scratch, blood crusts and secondary infection of scratching and causing.This state of an illness is touching, is easy to repeatedly, and most of patient is the performance of anxiety, lassitude in the vein, has a strong impact on patient's quality of life and physical and mental health.At present the treatment skin pruritus is except that positive searching with eliminate the various virulence factors, and is main still based on for oral administration and external medication.The pill that Western medicine antihistamine, vitamin, tranquilizer, hormone and Chinese medicine are arranged that oral medicine is commonly used, capsule etc., since these medicines arrive affected areas long action time, take effect slow, and the side effect to Liver and kidney and whole body is big, though certain anti-inflammatory anti-itch effect is arranged, but the not very willing acceptance of patient is therefore many clinically with the external medication skin pruritus.Dosage form commonly used has hormones ointment, emulsifiable paste and contains the liquid preparation of ethanol.These medicine for external use affected part that goes directly, the anti-inflammatory anti-itch effect is fast, but easily recurrence after the drug withdrawal, and life-time service can cause also that pachylosis, pore increase and many untoward reaction such as pigmentation, also easily makes pathogenic microorganism produce drug resistance, thereby increases the treatment difficulty.And the most medicine for external use only skin pruritus to some classification is effective, is not all effective to the skin pruritus due to all causes of disease.

Summary of the invention

The objective of the invention is for overcoming the deficiencies in the prior art, provide a kind of pure Chinese medicine anti-inflammation and itching-relieving liquid, determined curative effect, scientific formulation is reasonable, can be used for treating and improve skin pruritus due to a variety of causes, comprise mosquito bite, Transdermal absorption is fast and safety is without any side effects.The present invention also provides a kind of method for making of pure Chinese medicine anti-inflammation and itching-relieving liquid, extractive technique uniqueness, technology advanced person.

The object of the invention is achieved by the following technical programs: a kind of pure Chinese medicine anti-inflammation and itching-relieving liquid, mainly make by the raw material of following weight parts:

Radix Sophorae Flavescentis 15～50 Cortex Dictamni 10～40

The Radix Stemonae 10～40 Radix Saposhnikoviaes 5～35

Fructus Tribuli 5～35 Concha Haliotidis 10～50.

Described anti-inflammation and itching-relieving liquid is preferably made by the raw material of following weight parts:

Radix Sophorae Flavescentis 25～40 Cortex Dictamni 15～30

The Radix Stemonae 15～30 Radix Saposhnikoviaes 10～25

Fructus Tribuli 10～25 Concha Haliotidis 15～40.

The method for making of anti-inflammation and itching-relieving liquid of the present invention: the first step: take by weighing the raw material Concha Haliotidis by formulation weight, pulverize the deionized water that the back adds 100 times, prepare Concha Haliotidis extracting solution in ultrasonic dynamic extraction mode then;

Second step: take by weighing raw material Radix Sophorae Flavescentis, Cortex Dictamni, the Radix Stemonae, Fructus Tribuli, Radix Saposhnikoviae and be ground into coarse powder by composition of raw materials, each raw material after pulverizing is mixed, add above-mentioned Concha Haliotidis extracting solution, be heated to 90～100 ℃ and decoct extraction 2 hours, get supernatant ethanol sedimentation, after leaving standstill filtration no pure concentrated solution is made in the filtrate decompression distillation, promptly made pure Chinese medicine anti-inflammation and itching-relieving liquid.

Using method: suitable amount used externally, will count drops physic liquor and drip in the affected part or the pruritus position, smear until absorption every day 1-2 time with finger or cotton swab.

The present invention is the prescription foundation with dispeiling pathogenic wind and removing dampness, sterilizing and itch-relieving, with the Radix Sophorae Flavescentis is monarch drug, and be aided with Chinese medicine ingredients Cortex Dictamni, the Radix Stemonae, Radix Saposhnikoviae, the Fructus Tribuli that other has dispelling wind for relieving itching, the Chinese medicine Radix Sophorae Flavescentis contains number of chemical compositions such as matrine, oxymatrine and flavonoid, have heat clearing away, dampness, parasiticidal function, can treat toxic-heat and blood stasis, jaundice, skin pruritus, erosion of vulva pruritus due to damp pathogen and trichomonal vaginitis etc.; The shaggy-fruited dittany dermatome contains dictamine, dictamnolactone, sitosterol, obacunonic acid and trigonelline etc., have dispel the wind, dampness, heat clearing away, antidotal effect, can treat wind heat sore, scabies, itchy skin eruption, rheumatic arthralgia etc.; The chemical constituent of the Radix Stemonae is mainly multiple alkaloid, pharmacology's in vitro tests confirms, its decocting liquid and ethanol extract all have in various degree inhibitory action to various pathogens such as streptococcus pneumoniae, staphylococcus aureus, escherichia coli, Bacillus proteus etc., and mosquitos and flies larva, head louse, clothing louse and Cimex bedbug etc. are all had killing action; Windproof garment will contain chemical constituents such as volatile oil, mannitol, bitterness glycoside, has and delivers, dispels the wind, wins wet, analgesic effect; The major function of Fructus Tribuli is suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind and antipruritic.The present invention is equipped with not only has high osmotically active but also have the Concha Haliotidis extracting solution that nourishes the skin cell effect, and all medicines share, and play it altogether and imitate, and reach the effect of quick anti-inflammatory anti-itch.Concha Haliotidis contains several kinds of mineral elements, chitin, gallbladder element and aminoacid, and pharmacology test confirms to have heat clearing away calmness, anti-infective effect, can also nourish skin cell simultaneously.

Chinese prescription of the present invention is scientific and reasonable, and preparation technology is unique advanced, and the active constituent content height absorbs fast, easy to use.Both do not had the stimulation of ethanol preparation, do not had other unguentum or oil preparation not well sensation again skin to skin.Most importantly can effectively treat and improve the skin pruritus due to a variety of causes, comprise mosquito bite, especially fast, and without any side effects to the antiinflammatory of skin injury position, healing.

Using method is simple, and anti-inflammatory anti-itch is effective, determined curative effect, safety non-toxic, non-greasy skin, pollution clothes not, free from extraneous odour.

The present invention proves all that through acute toxicity test in mice, skin anaphylactic test and skin irritation test this product has no side effect, and is safe and reliable.The mouse test result: the present invention can obviously reduce dimethylbenzene induced mice auricle edema value, and showing has antiinflammation; Can obviously improve Cavia porcellus histamine phosphate itch-threshold, showing has itching-relieving action.

The specific embodiment:

Below in conjunction with specific embodiment the present invention is described in further detail, but the invention is not restricted to specific embodiment.

Embodiment 1:

A kind of pure Chinese medicine high efficiency anti-inflammatory antipruritic liquid, make by the raw material of following weight (kilogram):

Radix Sophorae Flavescentis 40 Cortex Dictamni 15

The Radix Stemonae 20 Radix Saposhnikoviaes 20

Fructus Tribuli 15 Concha Haliotidis 20

Concrete method for making is: the first step, at first take by weighing stone 20Kg Concha Haliotidis, Concha Haliotidis is pulverized the back add 100 times of deionized waters, prepare Concha Haliotidis extracting solution in ultrasonic dynamic extraction mode then;

Second goes on foot, takes by weighing respectively raw material 40Kg Radix Sophorae Flavescentis, 15Kg Cortex Dictamni, the 20Kg Radix Stemonae, 20Kg Radix Saposhnikoviae, 15Kg Fructus Tribuli, and pulverize separately becomes coarse powder, each raw material after pulverizing is mixed, add Concha Haliotidis extracting solution, be heated to 95 ℃ and decoct extraction 2 hours, get supernatant ethanol sedimentation, leave standstill after the filtration no pure concentrated solution is made in the filtrate decompression distillation, promptly make pure Chinese medicine anti-inflammation and itching-relieving liquid.

Embodiment 2:

Prepare pure Chinese medicine high efficiency anti-inflammatory antipruritic liquid according to embodiment 1 described method, each raw material weight (kilogram) component is:

Radix Sophorae Flavescentis 30 Cortex Dictamni 25

The Radix Stemonae 15 Radix Saposhnikoviaes 15

Fructus Tribuli 20 Concha Haliotidis 30

Embodiment 3:

Prepare pure Chinese medicine high efficiency anti-inflammatory antipruritic liquid according to embodiment 1 described method, each raw material weight (kilogram) component is:

Radix Sophorae Flavescentis 25 Cortex Dictamni 25

The Radix Stemonae 15 Radix Saposhnikoviaes 15

Fructus Tribuli 20 Concha Haliotidis 30

Embodiment 4:

Prepare pure Chinese medicine high efficiency anti-inflammatory antipruritic liquid according to embodiment 1 described method, each raw material weight (kilogram) component is:

Radix Sophorae Flavescentis 20 Cortex Dictamni 20

The Radix Stemonae 10 Radix Saposhnikoviaes 10

Fructus Tribuli 10 Concha Haliotidis 40

Embodiment 5:

Prepare pure Chinese medicine high efficiency anti-inflammatory antipruritic liquid according to embodiment 1 described method, each raw material weight (kilogram) component is:

Radix Sophorae Flavescentis 50 Cortex Dictamni 35

The Radix Stemonae 35 Radix Saposhnikoviaes 35

Fructus Tribuli 35 Concha Haliotidis 50

Adopt the medicine of various embodiments of the present invention to treat, using method is: suitable amount used externally, and will count drops physic liquor and drip in the affected part or the pruritus position, smear until absorption every day 1-2 time with finger or cotton swab.The mouse test result: can obviously reduce dimethylbenzene induced mice auricle edema value, showing has antiinflammation; Can obviously improve Cavia porcellus histamine phosphate itch-threshold, showing has itching-relieving action.

Carry out observation analysis by operating position, wherein eczema 5 examples, senile skin pruritus 12 examples, allergic dermatitis 2 examples, neurodermatitis 4 examples, urticaria 1 example, rubella 3 examples, beriberi 5 examples, mosquito bite 6 examples to 38 routine skin pruritus patients.The anti-inflammatory anti-itch total effective rate reaches 100% as a result.

Claims (3)

1. pure Chinese medicine anti-inflammation and itching-relieving liquid, it is characterized in that: the raw material by following weight parts is made:

Radix Sophorae Flavescentis 15～50 Cortex Dictamni 10～40

The Radix Stemonae 10～40 Radix Saposhnikoviaes 5～35

Fructus Tribuli 5～35 Concha Haliotidis 10～50.

2. a kind of pure Chinese medicine anti-inflammation and itching-relieving liquid according to claim 1, it is characterized in that: anti-inflammation and itching-relieving liquid is made by the raw material of following weight parts:

Radix Sophorae Flavescentis 25～40 Cortex Dictamni 15～30

The Radix Stemonae 15～30 Radix Saposhnikoviaes 10～25

Fructus Tribuli 10～25 Concha Haliotidis 15～40.

3. the method for making of claim 1 or 2 described pure Chinese medicine anti-inflammation and itching-relieving liquids is characterized in that: the first step: take by weighing the raw material Concha Haliotidis by formulation weight, pulverize the deionized water that the back adds 100 times, prepare Concha Haliotidis extracting solution in ultrasonic dynamic extraction mode then;

Second step: take by weighing raw material Radix Sophorae Flavescentis, Cortex Dictamni, the Radix Stemonae, Fructus Tribuli, Radix Saposhnikoviae and be ground into coarse powder by composition of raw materials, each raw material after pulverizing is mixed, add above-mentioned Concha Haliotidis extracting solution, be heated to 90～100 ℃ and decoct extraction 2 hours, get supernatant ethanol sedimentation, after leaving standstill filtration no pure concentrated solution is made in the filtrate decompression distillation, promptly made pure Chinese medicine anti-inflammation and itching-relieving liquid.