CN114788854A

CN114788854A - Traditional Chinese medicine composition and preparation method and application thereof

Info

Publication number: CN114788854A
Application number: CN202210468643.3A
Authority: CN
Inventors: 杨治
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-04-24
Filing date: 2022-04-24
Publication date: 2022-07-26
Anticipated expiration: 2042-04-24
Also published as: CN114788854B

Abstract

The invention belongs to the technical field of medicines, and discloses a traditional Chinese medicine composition and a preparation method thereof, aiming at the problems that the existing treatment of tinea manuum and tinea pedis is easy to relapse, the skin of the hand and foot is chapped, the existing western medicine treatment cost is higher, and the like. The traditional Chinese medicine composition comprises the following components in parts by weight: 8-12 parts of radix sophorae flavescentis, 5-9 parts of golden cypress, 5-9 parts of rhizoma smilacis glabrae, 3-7 parts of alum, 1-5 parts of sulfur, 5-9 parts of pepper, 8-12 parts of radix stemonae, 5-9 parts of clove, 5-9 parts of asarum, 8-12 parts of fructus cnidii, 5-9 parts of cortex dictamni, 1-3 parts of borneol, 8-12 parts of fructus trichosanthis, 1-5 parts of coptis chinensis and 5-9 parts of scutellaria baicalensis. Can be made into decoction, powder, soft extract, ointment, etc., and has effects of clearing away heat and toxic materials, eliminating dampness, relieving itching, caring skin and promoting granulation, and is suitable for treating tinea manuum, tinea pedis, and chapped skin.

Description

Traditional Chinese medicine composition and preparation method and application thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition as well as a preparation method and application thereof.

Background

Tinea pedis, commonly known as "beriberi", is caused by fungus invading local skin and generally occurs between the sole and toes, and the classic medical literature, "the surgical pithy of medical gold article" describes the symptoms visually: this syndrome is caused by downward flow of damp-heat from the stomach, and the foot is broken and rotten, which is very small, the itching cannot be relieved by rubbing, the skin must be rubbed and rotten, when the body fluids are smelly and water is ulcerated, the itching is still moderate the next day, the foot is not healed in the year, and the foot is extremely lingering.

The inventor works as a hygienist in troops in the early years, the training intensity of soldiers is high in summer high-temperature and high-humidity environment, the shoes are not breathable when people wear liberation shoes, and a lot of people infected with dermatophytosis are itchy and difficult to endure, and some people are accompanied with chapped skin.

The incidence rate of tinea pedis (beriberi) is extremely high, due to climate relation, the prevalence rate in south China is as high as 80%, although serious diseases cannot be solved, the beriberi is very itchy, and the beriberi can cause infection or tinea manuum, onychomycosis and the like when being scratched by hands.

The Western medicine is clinically used for treating tinea pedis by using a plurality of antifungal external preparations, most of which are antibiotics and hormones, can generate drug resistance after a long time, are repeated repeatedly and are easy to relapse, and the daily work and life are influenced by chapped skin of some hands and feet, and in addition, the cost is high after the traditional Chinese medicine is taken for a long time for 3 to 5 days after each 15 g.

Disclosure of Invention

The invention provides a traditional Chinese medicine composition and a preparation method thereof, aiming at the problems that the existing treatment of tinea manuum and tinea pedis is easy to relapse, the skin of the hand and the foot is chapped, the existing western medicine treatment cost is higher, and the like.

In order to achieve the purpose, the invention adopts the following technical scheme:

the invention provides a traditional Chinese medicine composition which comprises the following components in parts by weight: 8-12 parts of radix sophorae flavescentis, 5-9 parts of golden cypress, 5-9 parts of rhizoma smilacis glabrae, 3-7 parts of alum, 1-5 parts of sulfur, 5-9 parts of pepper, 8-12 parts of radix stemonae, 5-9 parts of clove, 5-9 parts of asarum, 8-12 parts of fructus cnidii, 5-9 parts of cortex dictamni, 1-3 parts of borneol, 8-12 parts of fructus trichosanthis, 1-5 parts of coptis chinensis and 5-9 parts of scutellaria baicalensis.

The application of the Chinese medicinal composition in preparing products for treating tinea manuum, tinea pedis and chapped skin is provided.

The Chinese medicinal composition can be prepared into various preparations, not limited to decoction, powder and soft extract.

The invention also provides a preparation method of a decoction based on the traditional Chinese medicine composition, which comprises the following steps:

step 1, grinding required borneol into fine powder, and adding alcohol until the borneol is completely dissolved to obtain borneol grinding fluid;

step 2, weighing the other components with corresponding amount, mashing, filling the components into a gauze or non-woven bag, placing the gauze or non-woven bag in a container, adding water to submerge the gauze or non-woven bag, soaking for 30-40 minutes, boiling with strong fire, decocting with slow fire for 15-20 minutes, placing at room temperature, adding the borneol grinding fluid in the step 1, and mixing uniformly to obtain the traditional Chinese medicine composition decoction.

The invention also provides a preparation method of the powder based on the traditional Chinese medicine composition, which comprises the following steps:

step 1, grinding required borneol into fine powder, and dissolving the fine powder in alcohol to obtain borneol grinding fluid;

and 2, weighing the other components in corresponding amount, mixing, crushing into the finest powder, adding the borneol grinding liquid in the step 1, grinding, sieving by a fifth sieve, and mixing uniformly to obtain the traditional Chinese medicine composition powder.

The invention also provides a preparation method of the soft extract based on the traditional Chinese medicine composition, which comprises the following steps:

step 1, grinding required borneol into superfine powder, and dissolving the powder in alcohol to obtain borneol grinding fluid;

step 2, weighing the other components with corresponding amount, mashing, placing in a container, soaking in water for 30-40 minutes, boiling with strong fire, decocting with slow fire for 30-40 minutes, placing at room temperature, adding the borneol grinding liquid in the step 1, concentrating, and collecting paste to obtain the traditional Chinese medicine composition soft extract.

Further, the finest powder means that the powder can pass through the six-mesh sieve totally, and the powder that can pass through the seven-mesh sieve is not less than 95%.

The performance and the efficacy of the raw materials of the components adopted in the invention are as follows:

sulfur: sulfur can generate hydrogen sulfide and sulfur sulfonic acid when contacting with skin secretion, has effects of removing toxic substance, killing parasites, relieving itching, killing fungi and scabies, and can be used for treating scabies, acne, intractable skin pruritus, scalp seborrheic dermatitis, miliaria, furuncle, etc.

Fructus cnidii: osthole and xanthotoxol have remarkable antifungal effect, and volatile oil and petroleum ether are main components for relieving itching, and have effects of killing parasite, relieving itching, and resisting allergy.

And (3) golden cypress: the effects of clearing heat, eliminating dampness, purging pathogenic fire and removing toxic substances are related to the effects of resisting pathogenic microorganisms, inflammation and influenza viruses, and have strong inhibitory effect on various skin pathogenic fungi in vitro, such as trichophyton violaceum, epidermophyton floccosum and the like.

Kuh-seng: the sophora flavescens decoction can inhibit the growth of various dermatophytes such as trichophyton, trichophyton microsporum, epidermophyton rubrum and the like.

Pepper: warming middle energizer to alleviate pain. The anti-inflammatory, analgesic and local anesthetic effects of the Chinese prickly ash depend on certain concentrations of Chinese prickly ash volatile oil and water extract, and the effects of the green Chinese prickly ash are stronger under the same dosage.

Clove: the clove volatile oil has a certain inhibition effect on staphylococcus aureus, escherichia coli, typhoid bacillus and the like at a lower concentration in vitro, and has the best inhibition effect on staphylococcus aureus; in addition, the clove oil can promote the transdermal absorption of the medicine and play the roles of relieving pain, warming the interior and dispelling cold.

And (3) borneol: the functions of detumescence and acesodyne are related to the bacteriostatic and anti-inflammatory effects of borneol and isoborneol; in addition, the borneol can be absorbed through the skin and can promote the transdermal process of other medicines, and the effect of promoting the transdermal absorption is mainly on the horny layer.

Scutellaria baicalensis and coptis chinensis: the functions of clearing heat, drying dampness, purging fire and detoxifying are related to the anti-inflammatory, anti-pathogenic microorganism and anti-allergic effects, and the antibacterial tea has obvious spectrum antibacterial effect.

Asarum: the volatile oil has strong analgesic and anti-inflammatory effects, and safrole in the volatile oil has strong antifungal effect in vitro.

And (3) complete snakegourd fruit: in vitro tests prove that the snakegourd fruit decoction or infusion has an inhibiting effect on gram-negative intestinal pathogenic bacteria such as escherichia coli and the like, staphylococcus, pneumococcus, alpha hemolytic streptococcus, influenza bacillus and the like. In addition, the antifungal agent also has an inhibiting effect on dermatophytic fungi such as the Odoku small-oz spore ringworm fungus, the Nocardia asteroides and the like.

Cortex dictamni: the water extract has antibacterial effect on a plurality of dermatophytes such as trichophyton violaceum, trichophyton concentricum, trichophyton schoenleinii, dermatophyte rubra and the like.

Alum: it is used externally to treat eczema and eczema, and has the functions of detoxicating, killing parasite, eliminating dampness, relieving itching, astringing dampness, promoting wound healing, stopping bleeding and eliminating slough. Has inhibitory effect on Staphylococcus aureus and Proteus.

Radix stemonae: moisten lung, lower qi to relieve cough, kill parasites and kill lice. The radix Stemonae water extract (1: 3) has effect in inhibiting various dermatophytes, and can inhibit growth of Trichophyton sinense at 20% concentration, Trichophyton schoenleinii, Microsporum Okawayanum and Microsporum lanuginosum at 40% concentration.

Glabrous greenbrier rhizome: detoxicating, removing dampness, cleaning joints, treating eczema and eczema caused by damp-heat, relieving swelling, resolving hard mass, and treating red swelling and ulceration of skin sore and carbuncle.

Compared with the prior art, the invention has the following advantages:

the traditional Chinese medicine composition comprises the following components by the mechanism: the traditional Chinese medicine composition of the invention is divided into two paths, one is: the sophora flavescens, the fructus cnidii and the cortex dictamni have the effects of clearing heat and drying dampness, killing parasites and relieving itching, and are suitable for tinea pedis caused by damp-heat; the second step is as follows: the Chinese prickly ash is pungent and warm, the sulfur sulfonic acid is warm, the two warm the middle and relieve pain, and the insect disinfestation and itching relief are suitable for tinea pedis caused by cold-dampness, and are monarch drugs together. The scutellaria baicalensis, the coptis chinensis and the golden cypress are used for respectively clearing damp-heat in the upper jiao, the middle jiao and the lower jiao, and the clove is used for warming the middle-jiao to dispel cold and relieving pain, and the two are used together and respectively used as main drugs and used as ministerial drugs. Glabrous greenbrier rhizome, sweet in nature and taste, light and flat, and has the effects of clearing heat and detoxicating, removing dampness, reducing swelling and dissipating stagnation; fructus Trichosanthis is sweet and cold, radix Stemonae is sweet and bitter, and slightly warm, both enter lung channel, and lung governs skin and hair, and is matched with Alumen for removing toxic substance and killing parasite, eliminating dampness and relieving itching, astringing dampness and healing sore, and accelerating the healing of chap wound; are used as adjuvant drugs. Borneol can clear heat and enhance the transdermal absorption of the medicine, and asarum can dispel cold and enhance the transdermal absorption of the medicine, so that the effect of promoting the circulation of qi and the cooperation are all guiding medicines.

The traditional Chinese medicine composition can clear away heat and toxic materials, eliminate dampness, relieve itching, moisten skin and promote granulation, and is suitable for patients with tinea manuum, tinea pedis or skin chapping.

Detailed Description

The technical solution of the present invention will be specifically and specifically described below with reference to the following examples. It should be noted that variations and modifications can be made by those skilled in the art without departing from the principle of the present invention, and these should also be construed as falling within the scope of the present invention.

The experimental methods used in the following examples are all conventional methods unless otherwise specified; reagents, materials and the like used in the following examples are commercially available unless otherwise specified.

Example 1

The traditional Chinese medicine composition of the embodiment comprises the following components in parts by weight: 8 parts of radix sophorae flavescentis, 5 parts of golden cypress, 5 parts of rhizoma smilacis glabrae, 3 parts of alum, 1 part of sulfur, 5 parts of pepper, 8 parts of radix stemonae, 5 parts of clove, 5 parts of asarum, 8 parts of fructus cnidii, 5 parts of cortex dictamni, 1 part of borneol, 8 parts of fructus trichosanthis, 1 part of coptis chinensis and 5 parts of scutellaria baicalensis.

The preparation method of the traditional Chinese medicine composition decoction comprises the following steps:

(1) grinding Borneolum Syntheticum into superfine powder (at least 95% of powder capable of passing through No. 7 sieve and No. six sieve), adding 95% ethanol in small amount for several times until completely dissolving to obtain Borneolum Syntheticum grinding solution;

(2) mashing the rest medicinal materials into coarse particles, filling the coarse particles with gauze or non-woven cloth bag, selecting appropriate container, adding water to submerge the bag for two times, soaking for 30 minutes, boiling with strong fire, decocting with slow fire for 15 minutes, standing at room temperature, adding Borneolum Syntheticum grinding fluid, and mixing well to obtain the Chinese medicinal decoction.

Example 2

The traditional Chinese medicine composition of the embodiment comprises the following components in parts by weight: 12 parts of lightyellow sophora root, 9 parts of amur corktree bark, 9 parts of glabrous greenbrier rhizome, 7 parts of alum, 5 parts of sulfur, 9 parts of pepper, 12 parts of sessile stemona root, 9 parts of clove, 9 parts of asarum, 12 parts of common cnidium fruit, 9 parts of densefruit pittany root-bark, 3 parts of borneol, 12 parts of snakegourd fruit, 5 parts of golden thread and 9 parts of baical skullcap root.

The preparation method of the decoction of the traditional Chinese medicine composition is the same as that in the example 1 except that the soaking time in the step 2 is 40 minutes and the decocting time with soft fire is 20 minutes.

Example 3

The traditional Chinese medicine composition of the embodiment comprises the following components in parts by weight: 10 parts of radix sophorae flavescentis, 8 parts of golden cypress, 7 parts of rhizoma smilacis glabrae, 5 parts of alum, 3 parts of sulfur, 7 parts of pepper, 10 parts of radix stemonae, 6 parts of clove, 8 parts of asarum, 10 parts of fructus cnidii, 7 parts of cortex dictamni, 2 parts of borneol, 10 parts of fructus trichosanthis, 3 parts of coptis chinensis and 7 parts of scutellaria baicalensis.

The preparation method of the decoction of the traditional Chinese medicine composition is the same as that in the example 1 except that the soaking time in the step 2 is 33 minutes and the decocting time with soft fire is 18 minutes.

Example 4

The preparation method of the traditional Chinese medicine composition powder comprises the following steps:

(1) grinding Borneolum Syntheticum into superfine powder (not less than 95% of powder which can pass through No. six sieve and No. 7 sieve), and dissolving in ethanol to obtain Borneolum Syntheticum grinding fluid;

(2) mixing the rest materials, pulverizing into superfine powder (not less than 95% of powder which can pass through six mesh sieve and 7 mesh sieve), adding Borneolum Syntheticum grinding solution, grinding, sieving with five mesh sieve (80 mesh sieve), mixing, metering, and packaging to obtain the Chinese medicinal composition powder.

Example 5

The preparation method of the traditional Chinese medicine composition soft extract comprises the following steps:

(1) grinding required borneol into finest powder (the powder can completely pass through a No. six sieve and can pass through a No. 7 sieve is not less than 95%), and dissolving the powder by using alcohol to obtain borneol grinding fluid;

(2) mashing the rest medicinal materials into coarse particles, selecting a proper container, adding water, soaking for 30 minutes, boiling with strong fire, decocting with slow fire for 40 minutes, standing at room temperature, adding the borneol grinding fluid, concentrating, collecting paste, subpackaging into small packages, and thus obtaining the traditional Chinese medicine composition decocted paste.

Example 6

The traditional Chinese medicine composition of the embodiment comprises the following components in parts by weight: 12 parts of radix sophorae flavescentis, 9 parts of golden cypress, 9 parts of rhizoma smilacis glabrae, 7 parts of alum, 5 parts of sulfur, 9 parts of pepper, 12 parts of radix stemonae, 9 parts of clove, 9 parts of asarum, 12 parts of fructus cnidii, 9 parts of cortex dictamni, 3 parts of borneol, 12 parts of fructus trichosanthis, 5 parts of coptis chinensis and 9 parts of scutellaria baicalensis.

The preparation method of the traditional Chinese medicine composition decocted extract is the same as the example 5 except that the soaking time in the step 2 is 40 minutes and the decocting time is 30 minutes.

Example 7

The traditional Chinese medicine composition of the embodiment comprises the following components in parts by weight: 8 parts of lightyellow sophora root, 5 parts of amur corktree bark, 5 parts of glabrous greenbrier rhizome, 3 parts of white alum, 1 part of sulfur, 5 parts of pepper, 8 parts of sessile stemona root, 5 parts of clove, 5 parts of asarum, 8 parts of common cnidium fruit, 5 parts of densefruit pittany root-bark, 1 part of borneol, 8 parts of complete snakegourd fruit, 1 part of golden thread and 5 parts of baical skullcap root.

The preparation method of the traditional Chinese medicine composition decocted extract is the same as the example 5 except that the soaking time in the step 2 is 36 minutes and the decocting time is 35 minutes.

Clinical treatment effect study:

the optimal clinical therapeutic effects of the decoction (example 1), the powder (example 4) and the soft extract (example 5) of the Chinese medicinal composition are respectively studied, and the use methods of different preparations are as follows:

(1) the application method of the decoction comprises the following steps: is used for soaking hands or feet once a day, 30 minutes each time, and generally 1-2 doses are cured. Each dose can be soaked for 7 days without removing medicinal residue, and each time the dose is heated to boil and warmed to prevent rancidity and deterioration, and the water can be added as appropriate for reducing water evaporation (note: the formula is an external use medicine, and can not be taken orally).

(2) The using method of the powder comprises the following steps: the powder is directly applied to the affected part or decocted in water for 15 minutes, and then the affected part is soaked in the warm liquid. The medicine is taken every morning and evening, 30 minutes each time, and 1-2 doses are generally cured. Each dose can be heated, boiled and warmed for 7 days each time to prevent rancidity and deterioration, and the water can be added as appropriate for the reduction of water evaporation (note: this formula is external use, and can not be taken orally).

(3) The application method of the soft extract comprises the following steps: diluting with water, heating, and soaking the affected part. The preparation is administered once a day, 30 min each time, and 1-2 doses can be used for 7 days.

The specific clinical treatment effects are as follows:

group of	Number of patients	Number of cure	Cure rate
				Example 1	80	76	95％
Example 4	80	74	92.5％
				Example 5	80	78	97.5％

The cure standard is as follows: the skin lesion symptoms are completely disappeared, and the mycoscope examination is negative.

The following are some typical cases:

case 1: mr. Zhang, age 27, blister, red and swollen, flowing water, itching and pain in toes; the powder is directly applied to the affected part, the symptoms are basically eliminated after one dose of the powder is used, only part of the powder is red and swollen, the powder is basically not affected by pain and itch, the powder is completely cured after two doses of the powder are continuously used, and no recurrence occurs.

Case 2: yang students, women, college students in school, 21 years old, suffered from beriberi for 4 years, had severe foot sweat, foot odor and foot itch, had frequent itching and had restlessness when sitting on class, and had no dare to wear sandals in summer. After the decoction is continuously used for soaking for three days, the foot odor and foot itching basically disappear, and only slight foot sweat is remained after the decoction is continuously used for 10 days.

Case 3: mr. Zhao, age 48, foot ulceration, especially severe cracking and ulceration of foot, pain disappears after the powder is applied for one week, and the powder can be completely recovered after being continuously used for two weeks (i.e. two doses) and no recurrence occurs in the recovery for nearly one year.

Case 4: a woman in the age of 34 years old is not aware of beriberi at ordinary times because a husband has the beriberi, the beriberi is infected by the husband himself, and the husband himself also engages in office clerical work, sweats on feet all day long, is sticky, and is very smelly. After the powder is continuously used for one week, the foot symptoms are relieved after the powder is soaked for 30 minutes in the morning and evening every day, the ladies can pull the old man to use the powder together, the beriberi of the ladies is completely recovered after the powder is used for one week, and the beriberi of the old man is also controlled.

Case 5: mr. Li, 58 years old, have more than 8 years of beriberi, easy sweaty feet, and very smelly feet, often the sole of the foot peels off, bloody silky nails, and also has developed in recent years, after continuously using the two preparations of the decoction paste, the feet are not smelly and the phenomenon of peeling off is not so serious.

Case 6: mr. Wedney, 38 years old, because of its job needs, need wear profession dress and build leather shoes throughout the year, leather shoes are not breathable and summer weather is hot, Mr. Wedney's sole grows a large piece of dense numb bubble, peculiar itch is incomparable, still accompany foot odor, use the cream of the invention to decoct after three days continuously according to the operation method, the sole bubble is obviously reduced, then use 4 days continuously again, a dosage totally, the sole bubble disappears completely, the foot is odorless too, prevent the beriberi from relapseing, Mr. Wedney uses a dosage continuously again, until now two years, Mr. Wedney shows that there is no phenomenon that the sole has emerged again.

Case 7: after the powder is used for spraying for one week, erosion parts obviously scab, and after the powder is continuously used for 3 weeks, erosion parts between toes are healed, and tinea manus also recovers to be healthy.

Case 8: wu Mr. Wu, 28 years old, engaged in outdoor work all the year round, suffered from tinea manuum for 2 years, and used products such as Daktonin during the period, but the effect is not good, the symptom can relapse after being temporarily improved, Wu Mr. Wu shows that the Wu Mr. Wu is very afflicted, and the tinea manuum is completely cured after 1 course of treatment by using the decoction of the invention and does not relapse.

Claims

1. The traditional Chinese medicine composition is characterized by comprising the following components in parts by weight: 8-12 parts of radix sophorae flavescentis, 5-9 parts of golden cypress, 5-9 parts of rhizoma smilacis glabrae, 3-7 parts of alum, 1-5 parts of sulfur, 5-9 parts of pepper, 8-12 parts of radix stemonae, 5-9 parts of clove, 5-9 parts of asarum, 8-12 parts of fructus cnidii, 5-9 parts of cortex dictamni, 1-3 parts of borneol, 8-12 parts of fructus trichosanthis, 1-5 parts of coptis chinensis and 5-9 parts of scutellaria baicalensis.

2. The use of the composition of claim 1 in the preparation of a product for treating tinea manuum, tinea pedis, and chapped skin.

3. The traditional Chinese medicine composition according to claim 1, characterized in that: the traditional Chinese medicine composition can be prepared into various preparations, including but not limited to decoction, powder and soft extract.

4. A method for preparing a decoction based on the traditional Chinese medicine composition of claim 1, which is characterized by comprising the following steps: the preparation method comprises the following steps:

step 2, weighing the other components in corresponding amount, mashing, filling the components into gauze or non-woven cloth bags, placing the gauze or non-woven cloth bags in a container, adding water to submerge and soak for 30-40 minutes, boiling the components with strong fire, decocting the components for 15-20 minutes with slow fire, placing the components at room temperature, adding the borneol grinding fluid in the step 1, and uniformly mixing the components to obtain the traditional Chinese medicine composition decoction.

5. A preparation method of powder based on the traditional Chinese medicine composition of claim 1, which is characterized by comprising the following steps: the preparation method comprises the following steps:

6. A method for preparing a soft extract based on the traditional Chinese medicine composition of claim 1, which is characterized by comprising the following steps: the preparation method comprises the following steps:

step 2, weighing the other components in corresponding amount, mashing, placing in a container, soaking with water for 30-40 minutes, boiling with strong fire, decocting with slow fire for 30-40 minutes, placing at room temperature, adding the borneol grinding fluid in the step 1, concentrating, and collecting paste to obtain the traditional Chinese medicine composition decocted paste.

7. The method for preparing a soft extract of the Chinese medicinal composition according to any one of claims 4 to 6, wherein the soft extract comprises: the finest powder means that the powder can completely pass through a six-mesh sieve, and the powder which can pass through a seven-mesh sieve is not less than 95%.