CN103705817A - External traditional Chinese medicinal preparation for treating tinea pedis and preparation method thereof - Google Patents
External traditional Chinese medicinal preparation for treating tinea pedis and preparation method thereof Download PDFInfo
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- CN103705817A CN103705817A CN201310708245.5A CN201310708245A CN103705817A CN 103705817 A CN103705817 A CN 103705817A CN 201310708245 A CN201310708245 A CN 201310708245A CN 103705817 A CN103705817 A CN 103705817A
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Abstract
The invention discloses an external traditional Chinese medicinal preparation for treating tinea pedis and a preparation method thereof, which can effectively solve the problem of local treatment of tinea pedis. The medicine is prepared by structurally processing sophora flavescens, stemona, dictamni cortex, cortex pseudolaricis, polygonatum kingianum, fructus cnidii, broom cypress fruit, fructus mume, cortex phellodendri, rheum officinale, clove, pericarpium zanthoxyli and liquorice. The drug effects of the medicines play a synergetic effect after the medicines are combined, so that the medicines are compatible to play the effects of clearing heat and drying dampness, nourishing blood and skin, and killing parasites to relieve itching. The preparation has a good curative effect after applied according to the dosage of each component, part of medicines is crushed and mixed with the other part of medicinal extract, so that the soaking drug effect of traditional Chinese medicines can be improved; the medicines are combined, and the technical scheme is adopted, so that, compared with the prior art, the external traditional Chinese medicinal preparation has the advantages of rich raw materials, simple preparation process, low cost, convenience in local application and good curative effect, and is easy to produce.
Description
Technical field
The present invention relates to Chinese medicine, particularly a kind of Chinese medicine for outer use for the treatment of tinea pedis and preparation method thereof.
Technical background
Tinea pedis is the superficial mycosis dermatoses that betides pedal skin, and the traditional Chinese medical science is called " tinea pedis ", is commonly called as " beriberi ".This disease is dermatology common disease, and frequently-occurring disease clinically be take toe seam, vola and occurred that pimple, vesicle, rotten to the corn, the dry desquamation companion of dipping pruritus are feature, and Xia Qiu is seriously ill, a lot of vesicles, erosion, and Winter-Spring is sick light, and how dry breach, often involves adult.According to its clinical manifestation, be divided into three types, vesicle, erosive type and desquamative, can transform between three types mutually, but be main mainly with one or two types, often can cause tinea unguium, tinea corporis, Tinea and microbid etc.In addition, the easy secondary antibacterial of vesicle and erosive type infects, and causes erysipelas, lymphadenitis, lymphangitis, cellulitis etc.Tinea pedis is widely distributed, distributes higher, as south China sickness rate can reach 50%～60% with the torrid zone and subtropical zone, though primary disease does not jeopardize patient's life, touching difficulty more, very easily recurs, and infectivity, has brought many adverse effects to patient's quality of life and public health.
Modern medicine thinks, the most common with trichophyton in the common pathogen of tinea pedis, often causes desquamative infringement; Secondly be alpha fungus and acrothesium floccosum, often cause vesicle infringement.Dynamic epidemiological study to tinea pedis pathogenic fungus in recent years, statistical data shows that infection by Candida albicans is in rising trend divided by outside encountered pathogenic bacteria, the tinea pedis due to it is the infringement of interphalangeal erosion type more.The Western medicine preparation for the treatment of for mycosis clinically at present mainly contains azole, polyenoid class etc., but various kinds of drug occurs the drug resistance problem of different strains to there is no the fine solution of method when clinical application, as the continuous appearance of azole drug Resistant strain and crossing drug resistant bacterial strain, original responsive drug susceptibility is reduced, and then make the kind that MIC value is higher infect more and more common.And patient is many owing to worrying the reasons such as Oral antifungal agents thing brings infringement to body and oral drugs are expensive, more options external antifungal preparation treatment superficial mycosis clinically.
In recent years, many traditional Chinese medical science workers are in order to overcome drug resistance, side effect and the deficiency such as expensive of Western medicine antifungal preparation, in conjunction with modern means of science and technology, and further good, the has a broad antifungal spectrum of research safety, traditional Chinese anti-fungi medicines and compound recipe thereof that curative effect is high.About Chinese medicine, the antibacterial action research of Common Pathogenic dermatophytosis is mainly contained to single medicinal material and the research of Chinese medicine compound to the antifungal activity in vitro of dermatophytosis and mechanism thereof at present, comprise experimentation and clinical research two aspects.Researcher adopts semi-solid medicine base mixing method or micro-dilution method to come Study of Traditional Chinese Medicine water decoction, ethanol extract or wherein In Vitro Bacteriostasis or the bactericidal action of a or two kind of monomer component mostly.Wherein the laboratory research of Chinese herb compound and the experiment research of single medicinal material and means are basic identical, and the clinical research of Chinese herb compound be take to common superficial mycosis if the treatment research of tinea manus and pedis, tinea corporis is as many.
In clinical practice uses, the local application for the treatment of tinea pedis selects upper Western medicine preparation more, next is the utilization of Chinese medicine for external application associating Western medicine external preparation, therefore, how further effectively to screen and to extract the active component that has antifungic action in Chinese herbal medicine, find safe, effective, economic traditional Chinese anti-fungi medicines external preparation, should become an important research direction.
Summary of the invention
For above-mentioned situation, for overcoming the defect of prior art, the object of the invention is to provide a kind of Chinese medicine for outer use for the treatment of tinea pedis and preparation method thereof, can effectively solve the topical therapeutic problem of tinea pedis.
For achieving the above object, the technical scheme that the present invention takes is that the Chinese medicine for outer use of described treatment tinea pedis is to be made by the medicine of following weight portion: 20～40 parts of Radix Sophorae Flavescentiss, 20～40 parts of the Radixs Stemonae, 20～40 parts of Cortex Dictamni, 20～40 parts of Cortex Pseudolaricis, 20～40 parts of Rhizoma Polygonatis, 20～40 parts of Fructus Cnidiis, 20～40 parts of the Fructus Kochiae, 20～40 parts of Fructus Mumes, 10～20 parts of Cortex Phellodendris, 10～20 parts of Radix Et Rhizoma Rhei, 5～15 parts of Flos Caryophyllis, 5～15 parts of Fructus Zanthoxylis, 5～15 parts, Radix Glycyrrhizae.
For obtaining the Chinese medicine for outer use of above-mentioned treatment tinea pedis, the preparation method that the present invention takes is: the Radix Sophorae Flavescentis of described weight portion, the Radix Stemonae, Cortex Dictamni, Rhizoma Polygonati, Fructus Mume, Cortex Phellodendri, Radix Et Rhizoma Rhei, Flos Caryophylli are pulverized respectively, cross 80 mesh sieves, be mixed into fine powder; The decocting that the Cortex Pseudolaricis of described weight portion, Fructus Cnidii, the Fructus Kochiae, Fructus Zanthoxyli, Radix Glycyrrhizae five kinds of Chinese medicine are doubled to add after consumption 8 times boils 1.5h, filter to obtain decocting liquid, then in medicinal residues, add the decocting of 6 times to boil 1.5h, filter to obtain decocting liquid, merge decocting liquid twice, be condensed into the extractum that relative density is 1.25 left and right; Above-mentioned fine powder and extractum are mixed and are placed in baking oven, 80 ℃ be dried to moisture and be less than 5% after, take out, then row pulverizes, become the fine powder of granularity approximately 180 μ m, place in clean container, under room temperature, press 25g/ bag specification subpackage.
Medicament selection Radix Sophorae Flavescentis of the present invention, the Radix Stemonae, Cortex Dictamni, Cortex Pseudolaricis, Rhizoma Polygonati, Fructus Cnidii, the Fructus Kochiae, Fructus Mume, Cortex Phellodendri, Radix Et Rhizoma Rhei, Flos Caryophylli, Fructus Zanthoxyli, Radix Glycyrrhizae combine, make each efficacy of drugs produce synergism these drug regimens, thereby effectively play altogether heat clearing and damp drying, blood-nourishing skin-moisturizing, the effect of killing parasites for relieving itching.
Said medicine, wherein: Radix Sophorae Flavescentis: remove root head and little fibrous root, after cleaning, take advantage of fresh slices dry, raw using; There is heat clearing and damp drying, parasite killing, the effect of diuresis.The Radix Stemonae: remove fibrous root, clean, dry, cut the raw use of sheet; There is nourishing the lung to arrest cough, the effect of parasite killing delousing.Cortex Dictamni: remove impurity, chip drying, raw using; There is heat clearing and damp drying, the effect of the removing toxic substances of dispeling the wind.Cortex Pseudolaricis: remove impurity, dry, raw using; There is parasite killing, antipruritic effect.Rhizoma Polygonati: cleaning, drying, cut sheet and use; There is boosting qi and nourishing yin, spleen invigorating, lung moistening, the effect of kidney tonifying.Fructus Cnidii: remove impurity, dry, raw using; There is killing parasites for relieving itching, dampness, the effect of warming the kidney to invigorate YANG.The Fructus Kochiae: remove impurity, dry, raw using; There is relieving stranguria by diuresis, clearing away heat-damp and promoting diuresis, antipruritic effect.Fructus Mume: after oven drying at low temperature, enucleation is raw to be used; There is astringing lung-QI and relieving cough, relieving diarrhea with astringents, relieving pain by calming ascaris, the effect of promoting the production of body fluid to quench thirst.Cortex Phellodendri: dry, section or shredding are raw to be used; Have heat clearing and damp drying, pathogenic fire purging is except steaming, the effect of detoxification sore treatment.Radix Et Rhizoma Rhei: except removing root, scrape off crust stripping and slicing dry, raw using; There is heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, the effect of eliminating blood stasis and inducing menstruation.Flos Caryophylli: remove impurity, dry, raw using; There is warming middle-JIAO to send down the adverse QI, dispersing cold for relieving pain, the effect of warming the kidney to activate YANG.Fructus Zanthoxyli: remove seed and impurity, dry, raw using; There is warming middle-JIAO to relieve pain, the effect of killing parasites for relieving itching.Radix Glycyrrhizae: remove fibrous root, dry, cut the raw use of sheet; There is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, relieving spasm to stop pain, heat-clearing and toxic substances removing, the effect of coordinating the actions of various ingredients in a prescription.
Tinea pedis is mainly due to wind, wet, heat, the excessive invasion and attack of worm from the mechanism of its morbidity of tcm theory, strongly fragrant in space between skin and muscles, excessive due to the skin.If see herpes, erosion, seepage flow taste water, pruritus incrustation person, mostly be damp and hot Sheng and cause; If see pachyderma, crack from dryness, pruritus person has hot and suffocating dryness-transformation more, disharmony between QI and blood, due to failure of skin and muscle to be nourished.Therefore control, work as heat clearing and damp drying, blood-nourishing skin-moisturizing, killing parasites for relieving itching.The kind heat clearing and damp drying of Radix Sophorae Flavescentis merit, parasite killing diuresis in side, the Radix Stemonae has the use of parasite killing delousing, and the two is combined into monarch drug, plays altogether the antipruritic effect of removing dampness and killing parasites; Cortex Dictamni, Cortex Pseudolaricis, Fructus Cnidii, the Fructus Kochiae, Fructus Mume are ministerial drug altogether, with the efficacy of a drug of principal drug assistance killing parasites for relieving itching; Cortex Phellodendri, Radix Et Rhizoma Rhei heat clearing and damp drying share and control tinea, are aided with Rhizoma Polygonati nature and flavor sweet flat, and blood-nourishing skin-moisturizing is antipruritic, and Flos Caryophylli, Fructus Zanthoxyli are pungent, temperature, and killing parasites for relieving itching, is adjuvant drug altogether, to help the antipruritic power of full side's removing dampness and killing parasites; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making medicine.Full side integrate bitter cold, Xin Wen, Gan Pingzhu medicine, and the special killing parasites for relieving itching of power makes dampness and not too simultaneously, and replenishing vital QI with drugs of warm nature skin moistening and not stagnant wet is just played heat clearing and damp drying, blood-nourishing skin-moisturizing, the merit of killing parasites for relieving itching altogether entirely.According to modern pharmacological research, confirm: multiple Chinese herbal medicine has antifungic action, according to incomplete statistics, reported that more than 300 kind of Chinese herbal medicine has antifungic action in various degree, as matrine has stronger bacteriostasis to trichophyton; The monomer composition chrysophanol of Radix Et Rhizoma Rhei has stronger bacteriostasis to trichophyton; Fructus Zanthoxyli volatile oil has and suppresses and killing effect trichophyton, microsporum lanosum etc.; Fructus Mume mainly contains citric acid, malic acid, and the materials such as succinic acid, water decoction has inhibitory action to multiple pathogenic bacteria and dermatophytes in vitro; Flos Caryophylli volatile oil has the effect of stronger anti-deep fungal; Fructus Cnidii is very strong to the inhibitory action of Candida albicans; Fructus Kochiae water logging agent all has inhibitory action in various degree etc. to dermatophytess such as rust budlet spore tinea bacterium, ulotrichy budlet spore tinea bacterium.
Because the present invention has taked technique scheme, compared with prior art, the present invention has abundant raw material, and preparation technology is simple, easily produces, and cost is low, and topical application is convenient, eutherapeutic advantage.
The specific embodiment
The Chinese medicine for outer use for the treatment of tinea pedis of the present invention is to be made by the medicine of following weight portion: 20～40 parts of Radix Sophorae Flavescentiss, 20～40 parts of the Radixs Stemonae, 20～40 parts of Cortex Dictamni, 20～40 parts of Cortex Pseudolaricis, 20～40 parts of Rhizoma Polygonatis, 20～40 parts of Fructus Cnidiis, 20～40 parts of the Fructus Kochiae, 20～40 parts of Fructus Mumes, 10～20 parts of Cortex Phellodendris, 10～20 parts of Radix Et Rhizoma Rhei, 5～15 parts of Flos Caryophyllis, 5～15 parts of Fructus Zanthoxylis, 5～15 parts, Radix Glycyrrhizae.
For obtaining the Chinese medicine for outer use of above-mentioned treatment tinea pedis, the preparation method that the present invention takes is: the Radix Sophorae Flavescentis of described weight portion, the Radix Stemonae, Cortex Dictamni, Rhizoma Polygonati, Fructus Mume, Cortex Phellodendri, Radix Et Rhizoma Rhei, Flos Caryophylli are pulverized respectively, cross 80 mesh sieves, be mixed into fine powder; The decocting that the Cortex Pseudolaricis of described weight portion, Fructus Cnidii, the Fructus Kochiae, Fructus Zanthoxyli, Radix Glycyrrhizae five kinds of Chinese medicine are doubled to add after consumption 8 times boils 1.5h, filter to obtain decocting liquid, then in medicinal residues, add the decocting of 6 times to boil 1.5h, filter to obtain decocting liquid, merge decocting liquid twice, be condensed into the extractum that relative density is 1.25 left and right; Above-mentioned fine powder and extractum are mixed and are placed in baking oven, 80 ℃ be dried to moisture and be less than 5% after, take out, then row pulverizes, become the fine powder of granularity approximately 180 μ m, place in clean container, under room temperature, press 25g/ bag specification subpackage.
Below in conjunction with embodiment, the specific embodiment of the present invention is elaborated
Embodiment mono-:
The Chinese medicine for outer use for the treatment of tinea pedis of the present invention is to be made by the medicine of following weight portion: 20 parts of Radix Sophorae Flavescentiss, 20 parts of the Radixs Stemonae, 20 parts of Cortex Dictamni, 20 parts of Cortex Pseudolaricis, 20 parts of Rhizoma Polygonatis, 20 parts of Fructus Cnidiis, 20 parts of the Fructus Kochiae, 20 parts of Fructus Mumes, 10 parts of Cortex Phellodendris, 10 parts of Radix Et Rhizoma Rhei, 5 parts of Flos Caryophyllis, 5 parts of Fructus Zanthoxylis, 5 parts, Radix Glycyrrhizae.
For obtaining the Chinese medicine for outer use of above-mentioned treatment tinea pedis, the preparation method that the present invention takes is: the Radix Sophorae Flavescentis of described weight portion, the Radix Stemonae, Cortex Dictamni, Rhizoma Polygonati, Fructus Mume, Cortex Phellodendri, Radix Et Rhizoma Rhei, Flos Caryophylli are pulverized respectively, cross 80 mesh sieves, be mixed into fine powder; The decocting that the Cortex Pseudolaricis of described weight portion, Fructus Cnidii, the Fructus Kochiae, Fructus Zanthoxyli, Radix Glycyrrhizae five kinds of Chinese medicine are doubled to add after consumption 8 times boils 1.5h, filter to obtain decocting liquid, then in medicinal residues, add the decocting of 6 times to boil 1.5h, filter to obtain decocting liquid, merge decocting liquid twice, be condensed into the extractum that relative density is 1.25 left and right; Above-mentioned fine powder and extractum are mixed and are placed in baking oven, 80 ℃ be dried to moisture and be less than 5% after, take out, then row pulverizes, become the fine powder of granularity approximately 180 μ m, place in clean container, under room temperature, press 25g/ bag specification subpackage.
Embodiment bis-:
The Chinese medicine for outer use for the treatment of tinea pedis of the present invention is to be made by the medicine of following weight portion: 30 parts of Radix Sophorae Flavescentiss, 30 parts of the Radixs Stemonae, 30 parts of Cortex Dictamni, 30 parts of Cortex Pseudolaricis, 30 parts of Rhizoma Polygonatis, 30 parts of Fructus Cnidiis, 30 parts of the Fructus Kochiae, 30 parts of Fructus Mumes, 15 parts of Cortex Phellodendris, 15 parts of Radix Et Rhizoma Rhei, 10 parts of Flos Caryophyllis, 10 parts of Fructus Zanthoxylis, 10 parts, Radix Glycyrrhizae.
Its preparation method is with embodiment mono-.
Embodiment tri-:
The technical scheme that the present invention takes is that the Chinese medicine for outer use of described treatment tinea pedis is to be made by the medicine of following weight portion: 40 parts of Radix Sophorae Flavescentiss, 40 parts of the Radixs Stemonae, 40 parts of Cortex Dictamni, 40 parts of Cortex Pseudolaricis, 40 parts of Rhizoma Polygonatis, 40 parts of Fructus Cnidiis, 40 parts of the Fructus Kochiae, 40 parts of Fructus Mumes, 20 parts of Cortex Phellodendris, 20 parts of Radix Et Rhizoma Rhei, 15 parts of Flos Caryophyllis, 15 parts of Fructus Zanthoxylis, 15 parts, Radix Glycyrrhizae.
Its preparation method is with embodiment mono-.
(1) major function of medicine of the present invention and therapeutic domain
1. major function:
Heat clearing and damp drying, blood-nourishing skin-moisturizing, killing parasites for relieving itching.
2. therapeutic domain:
Be applicable to the treatment of clinical common vesicle, erosive type and desquamative three types tinea pedis.
3. usage and consumption
(1) clean foot: clean pedal skin by warm water.(2) configuration tinea pedis soak: get one bag of medicated powder (25g/ bag), put into clean basin, add the about 1500ml of warm water of 35～40 ℃ to stir.(3) soak: trouble foot is put into soak and soak after 30～40 minutes, with sterile gauze, wipe away dry.Every day 1 time, being used in conjunction 2 weeks is 1 course for the treatment of.(4) during medication, enjoin patient should change clean footgear every day, stop using other are put preparation on the skin and avoid contacting the alkaline matters such as soap, handwashing liquid outward simultaneously.
(2) clinical observation of medicine of the present invention
1. case selection standard:
(1) diagnostic criteria: the diagnostic criteria with reference to national state-compiled textbook < < skin cypridology > > the 7th edition and the 7th edition relevant tinea pedis of < < Surgery of Chinese Medicine > > is formulated.
Blister type: the both sides that are 1. apt to occur in arch of foot and toe; 2. local mostly be in groups or disperses deeply in the subcutaneous vesicle of property, bleb wall thickness, content is limpid, is difficult for breaking, dry desquamation or be fused into kerionic vesicle after a couple of days, tears bleb wall off and can show honeycomb substrate and cerise erosion face; 3. pruritus.
Erosive type: 1. betide between toe seam, especially with common between 3,4 toes; 2. part shows as humidity between toe more, and skin dipping turns white; 3. violent pruritus, often scratches to the rotten pain of skin, seepage flow blood and slime, easily accompanying infection.
Desquamative: be 1. apt to occur in heel and sufficient sole of the foot portion; 2. locally show as cutin more and thicken, dry, coarse, desquamation, texture intensification, easily chaps, hemorrhage, and skin lesion also can spread to instep; 3. generally without pruritus, pain while chapping.
(2) inclusive criteria:
1. meet three types tinea pedis diagnostic criteria person;
2. the range of age is 16-68 year person;
3. directly microscopy is found pathomycete person;
4. in two weeks, do not accept other drug to tinea pedis treating person;
5. the person that signs Informed Consent Form.
(3) exclusion standard:
1. be not inconsistent diagnostic criteria person;
2. the age is below 16 years old or more than 68 years old, suckling and gravidic women;
3. there is miconazole nitrate allergies person;
4. other antifungal drugs history person is crossed in oral in 2 weeks or external;
5. merge the primary disease persons such as serious cardiovascular, cerebrovascular, liver, kidney, hemopoietic system, diabetes, malignant tumor, psychotic.
(4) rejecting and abort criterion:
1. not by scheme medication, affect effectiveness and safety judgement person;
2. bolter voluntarily in research process;
3. data is incomplete, affects effectiveness and safety judgement person.
4. in therapeutic process, the person that occurs serious adverse reaction.
2. observational technique:
(1) case grouping:
Adopt method random, contrast, MethodsThe cases enrolled is divided into 2 groups for the treatment of group and matched groups at random.
(2) Therapeutic Method:
Treatment group: external Chinese medicine preparation of the present invention soaks, and every day 1 time, gets one bag of medicated powder (25g/ bag), puts into clean basin, foams foot 30～40 minutes after adding the about 1500ml of warm water of 35～40 ℃ to stir, and being used in conjunction 2 weeks is 1 course for the treatment of.
Matched group: external has the Miconazole Nitrate Cream (trade name: daktarin of definite good therapeutic effect; Manufacturer: Xian-Janssen Pharmaceutical Ltd.; Authentication code: the accurate word H61020001 of traditional Chinese medicines), outer wiping affected part, every day 2 times, being used in conjunction 2 weeks is 1 course for the treatment of.
(3) observation index: formulate observation index according to skin lesion size and pruritus light and heavy degree, minute level Four scoring.
Skin lesion area: 0 minute, there is no skin lesion; 2 minutes, skin lesion area accounted for below 1/3 of foot area; 4 minutes, skin lesion area accounted for the more than 1/3 of foot area, below 2/3; 6 minutes, skin lesion area accounted for the more than 2/3 of foot area.
Pruritus degree: 0 minute, without pruritus; 2 minutes, accidental micro-itching; 4 minutes, paroxysmal pruritus; 6 minutes, persistence pruritus, and impact study, work and life.
(4) record case: observe once weekly, in time record patient change of illness state situation.
3. therapeutic evaluation:
With reference to < < clinical disease diagnosis, according to curing improvement standard > > and < < disease of tcm Standardization of diagnosis and curative effect > >, draft curative effect determinate standard, according to therapeutic index, binding to fungal microscopy result is carried out efficacy determination.
(1) therapeutic index: symptom total mark * 100% before therapeutic index=(the rear symptom total mark of symptom total mark-treatment before treatment)/treatment.
(2) efficacy determination:
1. recovery from illness, therapeutic index >=90%, continuous 4 equal negative patients of the direct microscopy of fungus;
2. effective: 70%≤therapeutic index < 90%, continuous 4 direct microscopies of fungus, wherein 2 persons that are not negative above;
3. effective: 30%≤therapeutic index < 70%, continuous 4 direct microscopies of fungus, wherein 1 negative patient;
4. invalid: therapeutic index < 30%, continuous 4 direct microscopies of fungus person that is not all positive.
(3) statistical method: all data acquisitions are undertaken by SPSS12.0 statistical analysis system.
4. result: treatment group 70 examples, recovery from illness 44 examples, effective 14 examples, effective 4 examples, invalid 8 examples, total effective rate 88.57%; Matched group 72 examples, recovery from illness 44 examples, effective 10 examples, effective 6 examples, invalid 12 examples, total effective rate 83.33%.Learn and process by statistics, two groups of general curative effects compare there was no significant difference (P > 0.05).
From therapeutic outcome, can find out, the Chinese medicine preparation clinical application that treatment group is used is effective.
In above-mentioned therapeutic process, the appearance that has no adverse reaction, drug safety, and relapse rate is low.
5. conclusion: by clinical observation, prove that the present invention has good therapeutic effect to tinea pedis topical therapeutic.Traditional Chinese medicine foot bath, medicine absorbs by foot, has not only played the effect of killing fungus treatment tinea pedis, simultaneously by medicine and warmth sensation to foot the stimulation through cave, the inclined to one side Sheng of adjusting energy and blood of human body, negative and positive declines partially, improves the resistance of human body to exopathogen, thereby has reduced the relapse rate of tinea pedis.In addition, topical transdermal absorbs the drug and can also avoid medicine to the stimulation of gastrointestinal and untoward reaction.This external medicine preparation, easy to use, safety, effectively, has no adverse reaction, and cost is low, easily produces, and has more outstanding clinical meaning, is the innovation on topical therapeutic tinea pedis medicine, and economic and social benefit is huge.
Claims (2)
1. treat a Chinese medicine for outer use for tinea pedis, the Chinese medicine for outer use that it is characterized in that described treatment tinea pedis is to be made by the medicine of following weight portion: 20～40 parts of Radix Sophorae Flavescentiss, 20～40 parts of the Radixs Stemonae, 20～40 parts of Cortex Dictamni, 20～40 parts of Cortex Pseudolaricis, 20～40 parts of Rhizoma Polygonatis, 20～40 parts of Fructus Cnidiis, 20～40 parts of the Fructus Kochiae, 20～40 parts of Fructus Mumes, 10～20 parts of Cortex Phellodendris, 10～20 parts of Radix Et Rhizoma Rhei, 5～15 parts of Flos Caryophyllis, 5～15 parts of Fructus Zanthoxylis, 5～15 parts, Radix Glycyrrhizae.
2. a preparation method for the treatment of as claimed in claim 1 tinea pedis Chinese medicine for outer use, it is characterized in that this preparation method is: the Radix Sophorae Flavescentis of described weight portion, the Radix Stemonae, Cortex Dictamni, Rhizoma Polygonati, Fructus Mume, Cortex Phellodendri, Radix Et Rhizoma Rhei, Flos Caryophylli are pulverized respectively, cross 80 mesh sieves, be mixed into fine powder; The decocting that the Cortex Pseudolaricis of described weight portion, Fructus Cnidii, the Fructus Kochiae, Fructus Zanthoxyli, Radix Glycyrrhizae five kinds of Chinese medicine are doubled to add after consumption 8 times boils 1.5h, filter to obtain decocting liquid, then in medicinal residues, add the decocting of 6 times to boil 1.5h, filter to obtain decocting liquid, merge decocting liquid twice, be condensed into the extractum that relative density is 1.25 left and right; Above-mentioned fine powder and extractum are mixed and are placed in baking oven, 80 ℃ be dried to moisture and be less than 5% after, take out, then row pulverizes, become the fine powder of granularity approximately 180 μ m, place in clean container, under room temperature, press 25g/ bag specification subpackage.
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Cited By (6)
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| CN104043005A (en) * | 2014-07-09 | 2014-09-17 | 华菊 | Medicine for treating tinea manus and tinea pedis |
| CN105125987A (en) * | 2015-09-09 | 2015-12-09 | 桂林盛兴电子科技有限公司 | External ointment for treating onychomycosis and preparation method thereof |
| CN105213913A (en) * | 2015-11-13 | 2016-01-06 | 青岛市市立医院 | A kind of foam washing liquid for the treatment of tinea pedis |
| CN105943665A (en) * | 2016-03-07 | 2016-09-21 | 合肥工业大学 | External-use powder for treating tinea pedis |
| CN106039167A (en) * | 2016-08-16 | 2016-10-26 | 成都中医药大学附属医院 | Medicine composition for treating tinea manuum and tinea pedis, preparation method and application thereof |
| CN114788854A (en) * | 2022-04-24 | 2022-07-26 | 杨治 | Traditional Chinese medicine composition and preparation method and application thereof |
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| CN1292268A (en) * | 2000-04-24 | 2001-04-25 | 缪振兴 | Medicine for curing tinea unguium |
| CN101664526A (en) * | 2008-09-02 | 2010-03-10 | 陈瑞华 | External Chinese medicinal lotion |
-
2013
- 2013-12-20 CN CN201310708245.5A patent/CN103705817B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1292268A (en) * | 2000-04-24 | 2001-04-25 | 缪振兴 | Medicine for curing tinea unguium |
| CN101664526A (en) * | 2008-09-02 | 2010-03-10 | 陈瑞华 | External Chinese medicinal lotion |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104043005A (en) * | 2014-07-09 | 2014-09-17 | 华菊 | Medicine for treating tinea manus and tinea pedis |
| CN105125987A (en) * | 2015-09-09 | 2015-12-09 | 桂林盛兴电子科技有限公司 | External ointment for treating onychomycosis and preparation method thereof |
| CN105213913A (en) * | 2015-11-13 | 2016-01-06 | 青岛市市立医院 | A kind of foam washing liquid for the treatment of tinea pedis |
| CN105943665A (en) * | 2016-03-07 | 2016-09-21 | 合肥工业大学 | External-use powder for treating tinea pedis |
| CN106039167A (en) * | 2016-08-16 | 2016-10-26 | 成都中医药大学附属医院 | Medicine composition for treating tinea manuum and tinea pedis, preparation method and application thereof |
| CN114788854A (en) * | 2022-04-24 | 2022-07-26 | 杨治 | Traditional Chinese medicine composition and preparation method and application thereof |
| CN114788854B (en) * | 2022-04-24 | 2023-09-12 | 杨治 | Traditional Chinese medicine composition and preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN103705817B (en) | 2016-05-25 |
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