CN114788854B

CN114788854B - Traditional Chinese medicine composition and preparation method and application thereof

Info

Publication number: CN114788854B
Application number: CN202210468643.3A
Authority: CN
Inventors: 杨治
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-04-24
Filing date: 2022-04-24
Publication date: 2023-09-12
Anticipated expiration: 2042-04-24
Also published as: CN114788854A

Abstract

The invention belongs to the technical field of medicines, and discloses a traditional Chinese medicine composition and a preparation method thereof, aiming at the problems that the existing tinea manus and pedis are easy to repeatedly occur after treatment, the skin of the hands and feet is cracked, the existing western medicine treatment cost is high, and the like. The traditional Chinese medicine composition comprises the following components in parts by weight: 8-12 parts of kuh-seng, 5-9 parts of amur corktree bark, 5-9 parts of glabrous greenbrier rhizome, 3-7 parts of alum, 1-5 parts of sulfur, 5-9 parts of Chinese prickly ash, 8-12 parts of radix stemonae, 5-9 parts of clove, 5-9 parts of manchurian wildginger, 8-12 parts of common cnidium fruit, 5-9 parts of dittany bark, 1-3 parts of borneol, 8-12 parts of snakegourd fruit, 1-5 parts of coptis chinensis and 5-9 parts of baical skullcap root. Can be made into decoction, powder, soft extract, ointment, etc., and has effects in clearing away heat and toxic materials, eliminating dampness, relieving itching, caring skin, and promoting granulation, and is suitable for people with tinea manus, tinea pedis or chapped skin.

Description

Traditional Chinese medicine composition and preparation method and application thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition, and a preparation method and application thereof.

Background

Tinea pedis commonly called as beriberi, caused by invasion of fungi into local skin, generally occurs between sole and toe, and classical medical literature "Yizongjin Jian surgical heart Ju" describes symptoms of tinea pedis in an image: this syndrome is caused by downward flow of damp-heat in stomach meridian, and foot is broken, so that it is very small, itching and rubbing can not be resolved, and itching is stopped when skin is broken and body fluid is stink and water is ulcerated, itching is still stopped the next day, and it is not healed in the past and is extremely lingering.

The inventor has been in army's high temperature and high humidity environment every summer in the early years, and fighter training intensity is high, and shoes are not breathable when putting on the shoes, and many people infected with beriberi are easy to wear, and itching is difficult to endure, and skin chapping is sometimes accompanied.

Tinea pedis (beriberi) has extremely high incidence rate, and due to climate, the incidence rate in the south of China is up to 80 percent, and although serious diseases cannot be counted, the tinea pedis is itchy, and infection, tinea manuum, onychomycosis and the like can be caused by scratching the tinea pedis with hands.

Clinically, western medicine is used for treating tinea pedis, and a plurality of antifungal external preparations, most of which are antibiotics and hormones, can generate drug resistance for a long time, are repeatedly repeated, are easy to relapse, have rhagades of hand and foot skin, influence daily work and life, and have higher cost after being used for a long time about 3-5 days for 15 g each time.

Disclosure of Invention

Aiming at the problems that the existing tinea manus and pedis are easy to repeatedly occur after treatment and the existing western medicine has high treatment cost, the invention provides a traditional Chinese medicine composition and a preparation method thereof.

In order to achieve the above purpose, the present invention adopts the following technical scheme:

the invention provides a traditional Chinese medicine composition which comprises the following components in parts by weight: 8-12 parts of kuh-seng, 5-9 parts of amur corktree bark, 5-9 parts of glabrous greenbrier rhizome, 3-7 parts of alum, 1-5 parts of sulfur, 5-9 parts of Chinese prickly ash, 8-12 parts of radix stemonae, 5-9 parts of clove, 5-9 parts of manchurian wildginger, 8-12 parts of common cnidium fruit, 5-9 parts of dittany bark, 1-3 parts of borneol, 8-12 parts of snakegourd fruit, 1-5 parts of coptis chinensis and 5-9 parts of baical skullcap root.

The application of the traditional Chinese medicine composition in preparing products for treating tinea manuum, tinea pedis and chapped skin is provided.

The Chinese medicinal composition can be prepared into various preparations, and is not limited to decoction, powder and decoction.

The invention also provides a preparation method of the decoction based on the traditional Chinese medicine composition, which comprises the following steps:

step 1, grinding the required borneol into the finest powder, and adding alcohol until the borneol is completely dissolved to obtain borneol grinding liquid;

and 2, weighing the rest components with corresponding amounts, mashing, filling into a gauze or non-woven fabric bag, placing into a container, adding water to submerge the gauze or non-woven fabric bag, soaking for 30-40 minutes, decocting for 15-20 minutes with slow fire after boiling with strong fire, placing at room temperature, adding the borneol grinding liquid in the step 1, and uniformly mixing to obtain the traditional Chinese medicine composition decoction.

The invention also provides a preparation method of the powder based on the traditional Chinese medicine composition, which comprises the following steps:

step 1, grinding the required borneol into the most fine powder, and dissolving the borneol into alcohol to obtain borneol grinding liquid;

and 2, weighing the rest components with corresponding amounts, mixing, crushing into the finest powder, adding the borneol grinding liquid in the step 1, grinding, sieving with a fifth sieve, and uniformly mixing to obtain the traditional Chinese medicine composition powder.

The invention also provides a preparation method of the decoction paste based on the traditional Chinese medicine composition, which comprises the following steps:

and 2, weighing the rest components with corresponding amounts, mashing, placing in a container, soaking in water for 30-40 minutes, boiling with strong fire, decocting with slow fire for 30-40 minutes, placing at room temperature, adding the borneol grinding liquid in the step 1, concentrating, and collecting the ointment to obtain the traditional Chinese medicine composition ointment.

Further, the finest powder means that the powder can pass through the sieve No. six in its entirety, and that the powder passing through the sieve No. seven is not less than 95%.

The performance and efficacy of the raw materials of each component adopted in the invention are as follows:

sulfur: the sulfur can be contacted with skin secretion to generate hydrogen sulfide and sulfuric acid, has effects in removing toxic substances, killing parasites, relieving itching, killing fungi and scabies, and can be used for treating scabies, acne, intractable skin pruritus, scalp seborrheic dermatitis, miliaria furuncle, etc.

Fructus Cnidii: the osthole and the xanthophyll have remarkable antifungal effect, and the volatile oil and the petroleum ether are main components for relieving itching, and have the effects of killing parasites, relieving itching and resisting allergy.

Cortex Phellodendri: the effects of clearing heat and drying dampness, purging fire and detoxifying are related to the effects of resisting pathogenic microorganisms, resisting inflammation and resisting influenza viruses, and the composition has a strong inhibition effect on various skin pathogenic fungi in vitro, such as trichophyton violaceum, epidermophyton floccosum and the like.

Radix Sophorae Flavescentis: the kuh-seng decoction has the effects of clearing heat, drying dampness, killing parasites, and inhibiting the growth of various dermatophytes such as trichophyton, bacillus pumilus, epizoon rubrum and the like.

Pricklyash peel: warm middle energizer and alleviate pain. The anti-inflammatory, analgesic and local anesthetic effects depend on the volatile oil and the aqueous extract of the pricklyash peel with certain concentration, and the green pricklyash peel has stronger effect under the same dosage.

Clove: the clove volatile oil has certain inhibition effect on staphylococcus aureus, escherichia coli, typhoid bacillus and the like in vitro at lower concentration, and has the best inhibition effect on the staphylococcus aureus; in addition, the clove oil can promote the percutaneous absorption of the medicine and exert the effects of relieving pain, warming the interior and dispelling cold.

Borneol: the detumescence and analgesia functions are related to the bacteriostasis and anti-inflammatory effects of borneol and isoborneol; in addition, borneol can be absorbed transdermally and promote the transdermal process of other medicines, and the effect of promoting transdermal absorption is mainly on the stratum corneum.

Radix scutellariae and rhizoma coptidis: the functions of clearing heat and drying dampness, purging fire and detoxifying are related to the anti-inflammatory, anti-pathogenic microorganism and anti-allergic effects, and the composition has remarkable spectrum antibacterial effects.

Asarum herb: the volatile oil has strong analgesic and anti-inflammatory effects, and safrole in the volatile oil has strong antifungal effect in vitro.

All snakegourd fruit: in vitro experiments prove that the trichosanthes decoction or infusion has inhibition effect on gram-negative intestinal pathogenic bacteria such as escherichia coli, and the like, and has inhibition effect on staphylococcus, pneumococcus, streptococcus A haemolyticus, influenza bacillus and the like. In addition, it has inhibiting effect on skin pathogenic fungi such as Bacillus pumilus and Nocardia asteroides.

Cortex Dictamni Radicis: the water extract has antibacterial effect on skin fungi such as Trichophyton violaceum, trichophyton concentric, trichophyton schoenleinken, and Epidermophyton rubrum.

Alum: it is used for treating eczema and wet sore by removing toxic substances, killing parasites, eliminating dampness, relieving itching, astringing dampness, promoting wound healing, stopping bleeding, and removing putrefaction. Has inhibiting effect on Staphylococcus aureus and Proteus.

Stemona root: lung moistening, qi descending, cough relieving, and parasite killing. The stemona root water immersion liquid (1:3) has an inhibiting effect on various dermatophytes, and can inhibit growth of the rhodosporidium parvum at 20% concentration and inhibit growth of the trichophyton violaceum, the trichophyton schoenleinii, the trichophyton ozhii and the trichophyton lanuiform at 40% concentration.

Rhizoma smilacis glabrae: detoxification, dehumidification and joint cleaning are used for treating eczema, damp sore and the like caused by damp heat, detumescence, resolving masses, sore, carbuncle, red swelling and ulcer.

Compared with the prior art, the invention has the following advantages:

the traditional Chinese medicine composition comprises the following components by mechanism: the traditional Chinese medicine composition provided by the invention is divided into two paths, one of which is: the kuh-seng, the fructus cnidii and the cortex dictamni have the effects of clearing heat and drying dampness, killing parasites and relieving itching, and are suitable for tinea pedis caused by damp heat; and two,: the pricklyash peel and the pricklyash peel are pungent in flavor and warm in sulfuric acid, and both are warm in nature and analgesic, and are insecticidal and antipruritic, so that the pricklyash peel and the pricklyash peel are suitable for tinea pedis caused by cold dampness and are all monarch drugs. The baikal skullcap root, the coptis root and the amur corktree bark are respectively used for clearing damp-heat in upper coke, middle coke and lower coke, and the clove is used for warming middle warmer, dispelling cold and relieving pain, and are used together as main drugs and ministerial drugs. Rhizoma smilacis glabrae, sweet in nature, light in taste, flat, capable of clearing away heat and toxic materials, removing dampness, and relieving swelling and resolving masses; fructus Trichosanthis is has effects of dispelling toxic substance, killing parasite, eliminating dampness, relieving itching, eliminating dampness, promoting wound healing, and promoting healing of rhagadia wound; are used together as adjuvant drugs. Borneol can clear heat and enhance the percutaneous absorption of the medicine, and asarum can dispel cold and enhance the percutaneous absorption of the medicine, so that the medicine can cooperate to achieve the effect of promoting the function of the medicine.

The traditional Chinese medicine composition disclosed by the invention has the effects of clearing heat and detoxicating, eliminating dampness and relieving itching, moisturizing skin and promoting tissue regeneration, and is suitable for people with tinea manuum, tinea pedis or chapped skin.

Detailed Description

The technical scheme of the invention is specifically and specifically described below in combination with the embodiment of the invention. It should be noted that variations and modifications can be made by those skilled in the art without departing from the principles of the present invention, which are also considered to be within the scope of the present invention.

The experimental methods used in the following examples are all conventional methods unless otherwise specified; the reagents, materials, etc. used in the examples described below are commercially available unless otherwise specified.

Example 1

The traditional Chinese medicine composition of the embodiment comprises the following components in parts by weight: 8 parts of kuh-seng, 5 parts of amur corktree bark, 5 parts of glabrous greenbrier rhizome, 3 parts of alum, 1 part of sulfur, 5 parts of Chinese prickly ash, 8 parts of radix stemonae, 5 parts of clove, 5 parts of manchurian wildginger, 8 parts of common cnidium fruit, 5 parts of dittany bark, 1 part of borneol, 8 parts of snakegourd fruit, 1 part of coptis root and 5 parts of baical skullcap root.

The preparation method of the traditional Chinese medicine composition decoction comprises the following steps:

(1) Grinding Borneolum Syntheticum into superfine powder (powder capable of passing through sieve six and powder capable of passing through sieve 7 is not less than 95%), and adding 95% ethanol for several times until all the ethanol is dissolved to obtain Borneolum Syntheticum grinding liquid;

(2) Mashing the rest medicinal materials into coarse granules, bagging with gauze or non-woven fabric, selecting a proper container, soaking in water for 30 min, boiling with strong fire, decocting with slow fire for 15 min, standing at room temperature, adding Borneolum Syntheticum grinding liquid, and mixing to obtain the decoction.

Example 2

The traditional Chinese medicine composition of the embodiment comprises the following components in parts by weight: 12 parts of kuh-seng, 9 parts of phellodendron, 9 parts of glabrous greenbrier rhizome, 7 parts of alum, 5 parts of sulfur, 9 parts of pepper, 12 parts of radix stemonae, 9 parts of clove, 9 parts of asarum, 12 parts of fructus cnidii, 9 parts of cortex dictamni, 3 parts of borneol, 12 parts of snakegourd fruit, 5 parts of coptis chinensis and 9 parts of baical skullcap root.

The preparation method of the traditional Chinese medicine composition decoction is the same as that of the example 1 except that the soaking time in the step 2 is 40 minutes and the decocting time with small fire is 20 minutes.

Example 3

The traditional Chinese medicine composition of the embodiment comprises the following components in parts by weight: 10 parts of kuh-seng, 8 parts of amur corktree bark, 7 parts of glabrous greenbrier rhizome, 5 parts of alum, 3 parts of sulfur, 7 parts of Chinese prickly ash, 10 parts of radix stemonae, 6 parts of clove, 8 parts of manchurian wildginger, 10 parts of common cnidium fruit, 7 parts of dittany bark, 2 parts of borneol, 10 parts of snakegourd fruit, 3 parts of coptis root and 7 parts of baical skullcap root.

The preparation method of the traditional Chinese medicine composition decoction is the same as that of the example 1 except that the soaking time in the step 2 is 33 minutes and the decocting time with small fire is 18 minutes.

Example 4

The preparation method of the traditional Chinese medicine composition powder comprises the following steps:

(1) Grinding Borneolum Syntheticum into fine powder (powder capable of passing through sieve six and powder capable of passing through sieve 7 is not less than 95%), and dissolving with ethanol to obtain Borneolum Syntheticum grinding liquid;

(2) Mixing the rest materials in proportion, pulverizing into the finest powder (powder capable of passing through the No. six sieve and powder capable of passing through the No. 7 sieve is not less than 95%), adding Borneolum Syntheticum grinding liquid, grinding, sieving with the No. five sieve (80 mesh), mixing, metering and packaging to obtain the Chinese medicinal composition powder.

Example 5

The preparation method of the traditional Chinese medicine composition soft extract comprises the following steps:

(1) Grinding desired Borneolum Syntheticum into fine powder (powder capable of passing through sieve six and powder capable of passing through sieve 7 is not less than 95%), and dissolving with ethanol to obtain Borneolum Syntheticum grinding liquid;

(2) Mashing the rest medicinal materials into coarse granules, selecting a proper container, soaking in water for 30 min, boiling with strong fire, decocting with slow fire for 40 min, standing at room temperature, adding Borneolum Syntheticum grinding liquid, concentrating, collecting paste, and packaging into small package.

Example 6

The preparation method of the Chinese medicinal composition soft extract is the same as in example 5 except that the soaking time in step 2 is 40 minutes and the decocting time is 30 minutes.

Example 7

The preparation method of the Chinese medicinal composition soft extract is the same as in example 5 except that the soaking time in step 2 is 36 minutes and the decocting time is 35 minutes.

Clinical treatment effect study:

the clinical treatment effects of the optimal traditional Chinese medicine composition decoction (example 1), powder (example 4) and decoction (example 5) are respectively studied, and the using methods of the different preparations are as follows:

(1) The using method of the decoction comprises the following steps: it is used for soaking hands or feet, and can be used for healing 1-2 doses each time 30 minutes in the morning and evening. Each dose can be soaked for 7 days without removing residues, and the decoction is boiled and cooled each time so as to avoid rancidity and deterioration, and the water can be added with reduced evaporation (the prescription is an external medicine and can not be taken orally).

(2) The use method of the powder comprises the following steps: the powder is directly applied to the affected part or decocted in water for 15 min, warmed and soaked in the affected part. Each time, 30 minutes each time, 1-2 doses generally heal each time in the morning and evening. Each dose can be used for 7 days, and is boiled and cooled each time to avoid rancidity and deterioration, and the water can be added with reduced evaporation (the prescription is an external medicine and can not be taken orally).

(3) The application method of the decoction comprises the following steps: diluting with water, heating, and soaking in the affected part. Each time in the morning and evening, 30 minutes each time, generally 1-2 doses can be healed, and each dose can be used for 7 days.

The specific clinical treatment effects are shown in the following table:

group of	Patient count	Cure number	Cure rate
				Example 1	80	76	95％
Example 4	80	74	92.5％
				Example 5	80	78	97.5％

The cure standard is: the skin damage symptoms completely disappear, and the mycoscopy is negative.

The following are some typical cases:

case 1: mr. with age 27, a watery bubble between toes, red swelling, running water, itching and pain; the powder of the invention is directly spread on the affected part, the symptoms are basically eliminated after one dose of the powder is used, only part of the powder is red and swollen, the powder is not affected by pain and itch basically, the powder is completely cured after two doses of the powder are continuously used, and no recurrence exists.

Case 2: yang Tongxue it is suitable for students at school, 21 years old, with beriberi for 4 years, sweaty feet, foot odor, itching, restlessness, and summer inappetence. After the decoction is continuously used for three days, foot odor and foot itching are basically eliminated, and after the decoction is continuously used for 10 days, only slight foot sweat is remained.

Case 3: mr. Zhao, 48 years old, foot fester, especially foot severe cracking and fester, pain is lost after the powder of the invention is applied for one week, and after two weeks (two doses) of continuous use, the patient is completely recovered, and no recurrence is caused after recovery for nearly one year.

Case 4: women, 34 years old, because the husband has beriberi, don't pay attention at ordinary times, have transmitted the beriberi, and also do office clerks work on the feet, sweat and paste on the feet throughout the day, and the feet are very bad. After the powder is continuously used for one week, foot symptoms are relieved after the powder is soaked for 30 minutes in the morning and evening, the old and the young women can use the powder together, and after the powder is used for one week, beriberi of the old and the young women is completely recovered, and the beriberi of the old and the young women is controlled.

Case 5: mr's plum, 58 years old, with beriberi for more than 8 years, easy sweaty feet, very bad smell of feet, frequent sole peeling and bleeding silk, and in recent years, onychomycosis is also concurrent, after two doses of the soft extract of the invention are continuously used, the feet are not bad smell, and the peeling phenomenon is less serious.

Case 6: the birth date is 38 years old, because the work needs, the user needs to wear the professional leather shoes all year round, the leather shoes are airtight, and the summer weather is hot, a large piece of melamine foam grows on the soles of the birth date, the itching is incomparable, the foot odor is also accompanied, the sole foam is obviously reduced after the soft extract of the invention is continuously used for three days according to the use method, then the sole foam is continuously used for 4 days, a total of one dose is obtained, the sole foam completely disappears, the feet are odorless, the beriberi is prevented from recurring, the birth date is continuously used for one dose, and the birth date is two years before, and the birth date shows that the phenomenon of sole foam does not occur.

Case 7: in the first two feet and toes erosion of 56 years old, with tinea manuum, pruritus but not scratching, the powder is decocted every day, after being applied for one week, the erosion is obviously crusted, and after being continuously used for 3 weeks, the toe erosion is healed, and the tinea manuum is healed.

Case 8: mr. Evo, 28 years old, the outdoor operation is carried out all year round, the tinea manuum is suffered from for 2 years, the product such as dyclonine is used in the period, but the effect is poor, the symptom recurs after being temporarily improved, the disease recurs repeatedly, mr. Evo indicates that the disease is very afflicted, and after the decoction provided by the invention is used for 1 treatment course, the tinea manuum is completely cured without recurrences.

Claims

1. The traditional Chinese medicine composition is characterized by comprising the following components in parts by weight: 10 parts of kuh-seng, 8 parts of amur corktree bark, 7 parts of glabrous greenbrier rhizome, 5 parts of alum, 3 parts of sulfur, 7 parts of Chinese prickly ash, 10 parts of radix stemonae, 6 parts of clove, 8 parts of manchurian wildginger, 10 parts of common cnidium fruit, 7 parts of dittany bark, 2 parts of borneol, 10 parts of snakegourd fruit, 3 parts of coptis root and 7 parts of baical skullcap root.

2. The use of the Chinese medicinal composition according to claim 1 for preparing a product for treating tinea manus, tinea pedis and chapped skin.

3. The traditional Chinese medicine composition according to claim 1, wherein: the Chinese medicinal composition can be prepared into various preparations, including but not limited to decoction, powder and decoction.

4. A method for preparing a decoction based on the traditional Chinese medicine composition of claim 1, which is characterized in that: the preparation method comprises the following steps:

and 2, weighing the rest components with corresponding amounts, mashing, filling into a gauze or non-woven fabric bag, placing into a container, adding water to submerge and soak for 30-40 minutes, decocting for 15-20 minutes by using small fire after boiling, placing at room temperature, adding the borneol grinding liquid in the step 1, and uniformly mixing to obtain the traditional Chinese medicine composition decoction.

5. A method for preparing a powder based on the traditional Chinese medicine composition of claim 1, which is characterized in that: the preparation method comprises the following steps:

6. A method for preparing a decoction based on the traditional Chinese medicine composition of claim 1, which is characterized in that: the preparation method comprises the following steps:

7. The method of any one of claims 4-6, wherein: the finest powder means that the powder can pass through the No. six sieve in its entirety, and the powder passing through the No. seven sieve is not less than 95%.