CN113663036B - Traditional Chinese medicine composition for treating facial acne and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating facial acne and preparation method thereof Download PDFInfo
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- CN113663036B CN113663036B CN202111036209.XA CN202111036209A CN113663036B CN 113663036 B CN113663036 B CN 113663036B CN 202111036209 A CN202111036209 A CN 202111036209A CN 113663036 B CN113663036 B CN 113663036B
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Abstract
The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating facial acne and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw materials: dandelion, selfheal, fructus forsythiae, spina gleditsiae, thunberg fritillary bulb, coix seed and moutan bark, wherein the traditional Chinese medicine composition at least comprises one of a traditional Chinese medicine composition for treating forehead acne, a traditional Chinese medicine composition for treating acne on two cheek areas or a traditional Chinese medicine composition for treating acne on the periphery of the chin, and the raw materials of the traditional Chinese medicine composition for treating forehead acne further comprise loquat leaf, honeysuckle and liquorice; the traditional Chinese medicine composition for treating acne on two cheek parts also comprises radix bupleuri, radix scutellariae, radix paeoniae rubra, rhizoma pinellinae praeparata and liquorice; the traditional Chinese medicine composition for treating the acne around the chin comprises the raw materials of phellodendron, rhizoma anemarrhenae and oyster. The invention discloses three traditional Chinese medicine compositions for treating facial acne, which can select different matching modes of the traditional Chinese medicine compositions according to the distribution of the acne in different areas of the face, have simple and practical diagnosis and treatment and are convenient to popularize and apply.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating facial acne and a preparation method thereof.
Background
The Western medicine considers that: acne is a multifactorial skin disease, and is associated with increased sebum production in the body, hyperkeratosis of the epithelial surface of the hair follicle opening, and proliferation of propionibacterium acnes in the hair follicle, as well as androgens. Mental factors, menstrual factors, and dietary factors can affect acne. The treatment mainly comprises antibiotics, hormones, tretinoin and local medicines, but has more side effects such as liver, kidney, stomach and intestine reactions, dryness, teratogenesis, endocrine dyscrasia and the like, and is easy to relapse.
The traditional Chinese medicine has a long history of diagnosis and treatment of acne, most ancient physicians treat acne through lung channel wind heat, lung channel blood heat, upper-jiao fire toxin, phlegm retention in viscera and spleen and lung damp heat, and the traditional Chinese medicine is prepared by orally taking loquat lung-clearing paste, five-flavor disinfection decoction, Bailian powder, Qingshangfeng decoction, Yurong powder, weeping forsythia powder, Hongyu powder, externally applied reversed powder and the like. In recent times, it is also indicated for deficiency of kidney yin, blood heat in lung and stomach, disharmony of Chong and ren meridians, damp-heat in lung and stomach, and phlegm-blood stasis. The Chinese patent medicine has the heat-clearing acne-eliminating tablet, golden flower acne-eliminating pill, detoxifying acne-eliminating pill and other products. However, the varieties are few, the classification is incomplete, the acne with the lung and stomach heat is mainly treated, and other types of medicines are few, so that the prescription dispensing of a doctor and the dispensing of a patient are effective and ineffective. The reason for this is that the symptoms of acne are classified into many categories and are also complicated, which is difficult for doctors and patients to grasp.
The disease is classified into exogenous disease and endogenous disease. Acne belongs to internal injury and non-exogenous diseases, and abnormal functions of spleen and stomach of human body are caused by improper diet, emotional disorder, overstrain after staying up all night and other pathogenic factors. Modern people overeat spicy and greasy food due to improper diet and greed drinking in cups, so that the dampness and heat in intestines and stomach are excessive; the stress of work is increased, the emotional fatigue causes the stagnated heat of the liver and the gallbladder, the soil cannot be dredged and the dampness is removed, and the damp heat of the spleen and the stomach is also caused, and the face, the chest and the back, the upper limbs and the like are fumigated through the channels and collaterals (the invention only discusses the face). The body tries to discharge pathogenic qi out of the body through meridians, especially the stomach meridian, gallbladder meridian, bladder meridian, conception and governor vessel and the exterior and interior meridians associated therewith, but due to the accumulation of heat leading to unsmooth circulation of facial meridians, local stasis is formed, heat is accumulated to form toxic purulence, damp is accumulated to form phlegm and to form a sac, and acne is formed in skin lesions with comedo, pimple, abscess, cyst, nodule and the like. Therefore, the overall etiology and pathogenesis is summarized into five characters of heat, dampness, toxicity, stasis and accumulation. The facial meridians are mainly the three yang meridians and the conception and governor vessels, and the acne is mainly related to the stomach meridian, the gallbladder meridian and the conception vessel.
However, no one has developed the acne medicine based on the analysis of the characteristics of facial acne caused by the coexistence of five pathogenesis of heat, dampness, toxicity, stasis and knot due to bad living habits and life styles of modern people and belonging to different viscera and meridians, so the curative effect is not high.
In view of this, the present invention is proposed.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to provide the traditional Chinese medicine composition for treating facial acne and the preparation method thereof.
In order to achieve the purpose, the invention is solved by the following technical scheme:
a traditional Chinese medicine composition for treating facial acne comprises the following raw materials: dandelion, selfheal, fructus forsythiae, spina gleditsiae, thunberg fritillary bulb, coix seed and moutan bark, wherein the traditional Chinese medicine composition at least comprises one of a traditional Chinese medicine composition for treating forehead acne and a traditional Chinese medicine composition for treating both cheek acne or a traditional Chinese medicine composition for treating submental periphery acne, and the traditional Chinese medicine composition for treating forehead acne also comprises loquat leaf, honeysuckle and liquorice; the traditional Chinese medicine composition for treating acne on two cheek parts also comprises radix bupleuri, radix scutellariae, radix paeoniae rubra, rhizoma pinellinae praeparata and liquorice; the traditional Chinese medicine composition for treating the acne around the chin comprises the raw materials of phellodendron, rhizoma anemarrhenae and oyster.
The traditional Chinese medicine composition for treating forehead acne is prepared from the following raw materials in parts by weight: 5-15 parts of loquat leaves, 15-45 parts of dandelion, 10-30 parts of honeysuckle, 15-45 parts of coix seeds, 5-15 parts of selfheal, 10-30 parts of fructus forsythiae, 5-15 parts of spina gleditsiae, 5-15 parts of thunberg fritillary bulb, 10-20 parts of moutan barks and 5-10 parts of liquorice.
The traditional Chinese medicine composition for treating acne on two cheeks is prepared from the following raw materials in parts by weight: 5 to 15 parts of radix bupleuri, 15 to 25 parts of radix scutellariae, 5 to 15 parts of thunberg fritillary bulb, 10 to 30 parts of fructus forsythiae, 10 to 20 parts of moutan bark, 5 to 15 parts of red paeony root, 5 to 15 parts of rhizoma pinellinae praeparata, 15 to 45 parts of dandelion, 5 to 10 parts of liquorice, 15 to 45 parts of semen coicis, 5 to 15 parts of spina gleditsiae and 5 to 15 parts of selfheal.
The traditional Chinese medicine composition for treating the submental perioral acne is prepared from the following raw materials in parts by weight: 5 to 15 parts of phellodendron, 5 to 15 parts of rhizoma anemarrhenae, 10 to 45 parts of coix seed, 5 to 15 parts of thunberg fritillary bulb, 5 to 15 parts of selfheal, 15 to 45 parts of dandelion, 5 to 15 parts of spina gleditsiae, 5 to 15 parts of moutan bark, 15 to 30 parts of oyster and 10 to 30 parts of forsythia.
The preparation method of the traditional Chinese medicine composition for treating facial acne comprises the following steps:
(1) weighing loquat leaves, dandelion, honeysuckle, coix seeds, selfheal, weeping forsythia, spina gleditsiae, thunberg fritillary bulb, tree peony bark and liquorice according to parts by weight, drying the obtained raw materials, uniformly mixing, grinding into powder, sieving by a 50-100-mesh drug detection sieve to prepare traditional Chinese medicine powder, and sterilizing under an ultraviolet germicidal lamp for 8 hours to obtain an intermediate I;
(2) weighing radix bupleuri, radix scutellariae, thunberg fritillary bulb, fructus forsythiae, moutan bark, red paeony root, rhizoma pinellinae praeparata, dandelion, liquorice, semen coicis, spina gleditsiae and selfheal according to the weight parts, drying the obtained raw materials, uniformly mixing, grinding into powder, sieving by a 50-100-mesh medicine detection sieve to prepare traditional Chinese medicine powder, and sterilizing for 8 hours under an ultraviolet sterilizing lamp to obtain an intermediate II;
(3) weighing cortex Phellodendri, rhizoma anemarrhenae, Coicis semen, Bulbus Fritillariae Thunbergii, Prunellae Spica, herba Taraxaci, spina Gleditsiae, cortex moutan, Concha Ostreae and fructus forsythiae, drying the obtained raw materials, mixing well, grinding into powder, sieving with 50-100 mesh sieve to obtain traditional Chinese medicine powder, and sterilizing under ultraviolet sterilizing lamp for 8h to obtain intermediate III;
(4) mixing one or two or three of the intermediates I, II and III to make into oral preparation.
The oral preparation can be tablet, dispersant, soft capsule, granule, pill, dripping pill, gel and oral liquid.
The preparation process of the tablet in the oral preparation is as follows: selecting one or two or three of the intermediates I, II and III, adding Gypsum Fibrosum powder, common adjuvants and binder, mixing, granulating, drying, adding lubricant, mixing, grading, and tabletting to obtain tablet; the common auxiliary materials are selected from one or a mixture of more than two of starch, powdered sugar, microcrystalline cellulose, inorganic salts and mannitol; the adhesive is one of distilled water or 30-70% ethanol solution; the lubricant is one of 0.1-1% of magnesium stearate, 0.1-3% of talcum powder or 0.1-0.3% of superfine silica gel powder.
The preparation process of the soft capsule in the oral preparation is as follows: selecting one or two or three of the intermediates I, II and III, adding 1-15% of polyethylene glycol, plasticizer, disintegrating agent, curcumin, ferric oxide, wetting agent and suspending agent, mixing well, and filling into soft capsules; the plasticizer is selected from glycerol or polyalcohol; the disintegrating agent is selected from dried starch or effervescent disintegrating agent; the wetting agent is one of 30-70% ethanol or liquid paraffin; the suspending agent is selected from one of beeswax, aluminum monostearate or ethyl cellulose.
The invention has the following beneficial effects:
(1) the invention provides three related traditional Chinese medicine compositions by comprehensively and deeply researching the pathogenesis of acne and bioholography of viscera, meridians and the like. The forehead is at the highest position of the face and belongs to the heart and lung; the periphery of the submental opening is positioned at the lowest part of the face and belongs to the kidney; the liver and gallbladder meridians are located in the hypochondriac area, and the liver and gallbladder are located on the lateral side of the human body. The traditional Chinese medicine composition provided by the invention is reasonable in compatibility, combines the five pathogenies of heat, dampness, toxicity, stasis and stagnation of the facial meridians and viscera, and the prepared special prescription has no side effect, has a good treatment effect on facial acne, can radically cure facial acne without recurrence, is simple and practical in treatment, is convenient to popularize and apply, does not need guidance of doctors, and can be mastered by patients;
(2) because the loquat leaves have the effects of clearing away the lung-heat, harmonizing the stomach, eliminating phlegm and reducing internal heat, the honeysuckle has the effects of removing heat and toxic materials, treating carbuncle-abscess, scabies and red bayberry malignant sore, and the liquorice has the effects of removing toxic materials and purging fire, and the traditional Chinese medicine composition for treating forehead acne has the effects of clearing away the lung-heat, cooling the heart, promoting diuresis, removing toxin, removing blood stasis and dissipating stagnation by matching with other traditional Chinese medicine raw materials, and can be used for treating the heart and lung so as to eliminate the acne on the forehead; the radix bupleuri has the effects of relieving exterior and interior syndromes, soothing liver, relieving depression, raising yang, lifting subsidence, allaying fever and preventing malaria, the radix scutellariae has the effects of clearing heat, eliminating dampness, purging fire and detoxifying, the radix paeoniae rubra has the effects of clearing heat, cooling blood, removing stasis and relieving pain, the pinellia ternate has the effects of eliminating dampness, reducing phlegm, lowering adverse qi, preventing vomiting, relieving distension and dispersing masses (prepared rhizoma pinelliae is toxic because of unprocessed rhizoma pinelliae), the radix glycyrrhizae has the effects of detoxifying and purging fire, and the traditional Chinese medicine composition for treating the two-buccal acne has the effects of soothing liver, benefiting gallbladder, resolving dampness, detoxifying, resolving masses and eliminating cysts by matching with other traditional Chinese medicine raw materials, so that the acne on the two cheeks can be eliminated by treating the liver and gallbladder; because the phellodendron has the effects of clearing heat and drying dampness, purging fire and removing steam, detoxifying and treating sore, the rhizoma anemarrhenae has the effects of clearing heat and purging fire, nourishing yin and moistening dryness, the oyster has the effects of benefiting yin and suppressing yang, and inducing astringency, and the traditional Chinese medicine composition for treating the acne around the periphery of the chin has the effects of clearing kidney fire, detoxifying and resolving dampness, and resolving masses and eliminating cysts by matching with other traditional Chinese medicine raw materials, and can be used for treating the kidney so as to eliminate the acne around the periphery of the chin;
(3) according to the distribution of acne on different areas of face, the matching forms of different compositions can be selected (wherein the weight ratio of the same medicine is only the maximum ratio of one of the medicines), such as: selecting a traditional Chinese medicine composition for treating the acne on the forehead when the acne exists on the forehead; selecting a traditional Chinese medicine composition for treating acne on two cheek parts when acne exists on the two cheek parts; selecting a traditional Chinese medicine composition for treating acne around the periphery of the submental opening when the periphery of the submental opening has the acne; the forehead and the two cheeks have acnes, the traditional Chinese medicine composition for treating the forehead and the traditional Chinese medicine composition for treating the two cheeks can be used together; the two cheek parts and the periphery of the submental opening have acnes, and the traditional Chinese medicine composition for treating the two cheek parts and the traditional Chinese medicine composition for treating the periphery of the submental opening can be used as a compound prescription; the forehead and the lower chin can have acne, and the traditional Chinese medicine composition for treating the forehead acne and the traditional Chinese medicine composition for treating the periphery of the lower chin can be used together; the three compositions are combined when acne is on the whole face;
(4) on the basis of ensuring the treatment effect of the original traditional Chinese medicine, the invention provides the preparation methods of the tablets and the soft capsules for the convenience of storage, carrying and taking of patients, can be directly taken by water, is safe and sanitary, is convenient to carry and store, is easy to produce and sell, and changes the situation of fussy taking method of the traditional Chinese medicine preparation.
The special pharmacology of the traditional Chinese medicine composition for treating forehead acne is as follows:
loquat leaves: bitter and neutral, clearing lung-heat and harmonizing stomach, descending qi and resolving phlegm, lowering fire.
Honeysuckle flower: remove heat and toxic materials. It is indicated for abscess, deep-rooted carbuncle, scabies, tinea and red bayberry malignant boil.
Licorice root: the flavor is sweet and mild, and is mainly indicated for the five zang organs and six fu organs with pathogenic cold and heat. Incised wound , detoxification; unprocessed with the effect of purging heat and fire, while stir-baked with warm fire; the twelve main meridians are passed through, the toxin of various herbs is removed, the raw one is used for regulating qi, tonifying spleen and stomach, purging heart fire and generating lung-heat. Purging heat when cold agent is added; produce and purge fire, stir-baked and warm the middle energizer. Removing the pain of the tip and the ureter, eliminating carbuncle, deep-rooted carbuncle, inflammation, swelling and inflammation, and removing chest heat, and the three should be generated; the recipe is used for treating carbuncle, swelling, sore and ulcer, but the syndrome of fullness in the middle energizer is contraindicated because it passes through the twelve meridians and relieves all the toxicity of herbs.
The special pharmacology of the traditional Chinese medicine composition for treating the acne on the two cheeks is as follows:
bupleurum root: bitter and mild taste, dominating qi accumulation in the stomach and intestine of heart, abdomen, diet, and pathogenic cold and heat, aging and refreshing; the drugs for the shaoyang channel and the jueyin channel; heat from the pathogenic factors of the mild shaoyang jueyin enters the blood chamber and dissipates the twelve main meridians of the ulcer and gangrene; the four meridian-moving herbs in hand and foot shaoyang jueyin also purge liver fire, treat sores and ulcers, disperse all meridians blood and congeal qi, and have the same actions as Lian Qiao.
Scutellaria baicalensis: bitter and neutral in flavor and mainly responsible for all heat. Malignant ulcer, deep-rooted carbuncle, erosion, and fire ulcer; recipes for treating the taiyin meridian. It is indicated for damp-heat in lung, manifested as up-heat, red and swollen eyes, blood stasis and exuberance of blood. The lung is obstructed by fire and pathogenic factors. Purging the fire in the lung; bitter in heart and cold over heat. Purging excessive fire in middle energizer, and removing dampness and heat from spleen. Jaundice with five stranguria, blood retention with excess heat in the adverse flow of qi in the blood system, superficial infection, sores and ulcers, and various blood loss.
Red peony root: red peony root, radix Paeoniae Rubra has the effects of inducing diuresis to remove heat, resolving carbuncle, swelling, removing hard mass, and is the key herb for eye pain due to excessive fire; red peony root, bitter in flavor, can purge toxic heat and abscess to dissipate toxic qi. Regulating female menstruation, removing blood stasis and promoting lactation.
Pinellia tuber (prepared rhizoma Pinelliae Preparata is used in the invention because unprocessed rhizoma Pinelliae is toxic): pungent and warm in property, slippery and dry in body. Harmonize stomach and invigorate spleen, and move gallbladder meridian. Descending qi to arrest vomiting, eliminating dampness and phlegm, promoting urination and defecation, and promoting the flow of water and qi to moisten kidney and dryness, and harmonizing stomach qi to activate yang to improve eyesight; it is always mainly used for all phlegm. Unprocessed pinellia tuber eliminates carbuncle and swelling; ban Xia is not a specific herb for phlegm, so it is pungent in flavor and can dissipate nodulation, dry in nature and remove dampness, so it is favored by spleen.
Licorice root: the flavor is sweet and mild, and is mainly indicated for the five zang organs and six fu organs with pathogenic cold and heat. Incised wound , detoxification; unprocessed with the effect of purging heat and fire, while stir-baked with warm fire; the twelve main meridians are passed through, the toxin of various herbs is removed, the raw one is used for regulating qi, tonifying spleen and stomach, purging heart fire and generating lung-heat. Purging heat when cold agent is added; produce and purge fire, stir-baked and warm the middle energizer. Removing the pain of the tip and the ureter, eliminating carbuncle, deep-rooted carbuncle, inflammation, swelling and inflammation, and removing chest heat, and the three should be generated; the recipe is passed through the twelve meridians and can remove all the toxicity of herbs, so it is called by the old to treat carbuncle, swelling, sores and ulcers, but should not be used for treating full-bodied middle energizer syndrome.
The pharmacology of special traditional Chinese medicines in the traditional Chinese medicine composition for treating the acne around the submental periphery is as follows:
phellodendron bark: bitter, cold and slightly pungent. Sinking yin and descending to purge the bladder fire, which is the guiding drug for the taiyang meridians. Remove dampness and clear heat, strengthen kidney by annealing, treat paralysis, bone-steaming, dysentery and sores.
Rhizoma anemarrhenae: pungent, bitter, cold and slippery. Enters the lung and kidney meridians and qi system. Purging pathogenic heat in bladder and excessive fire in lower energizer to cause inflammation of the ministerial fire and lung heat in the clear and descending way, purging stomach heat, moistening dryness, nourishing yin, and promoting urination and defecation; the upper part of the body is used to clear lung-heat and purge fire, while the lower part is used to moisten kidney and dryness to nourish yin, which enters the qi system of the two meridians. Huang Bai enters blood system of two meridians, so two herbs must mutually reinforce each other and move.
Oyster shell: slightly cold smell, salty and mild taste, and no toxicity. Enter the foot-shaoyin channel. Salty taste can soften hardness. Can remove scrofula and all sores; salty in nature can soften hardness and resolve phlegm, eliminate scrofula and tuberculosis, and treat hernia in the old blood.
The pharmacology of part of traditional Chinese medicines for treating facial acne in the prior art is as follows:
and (3) fructus forsythiae: has bitter and even taste. Mainly treating cold and heat; fistula of rats; scrofula; abscess and swelling; malignant sores; goiter and tumor; heat is generated; poison parasitic insects; for scrofula due to cold and heat, all malignant sores and swelling, heart meridian cold and heat purging, they are used by all families, and also as the herbs for sores and the sacred halloysites; bitter and slightly cold. Ascending in property, entering heart and pericardium to purge fire, removing damp-heat from triple energizer, large intestine and gallbladder channels, dissipating blood, gathering qi, inducing diuresis and killing parasites. Is a key herb for treating twelve meridian sores; forsythia fruit, fructus forsythiae, with light and clear smell, floating body, cold nature, floating body, removing excess, cold nature, prevailing heat, always treats triple energizer, all the aspects of meridians. The heart and lung are in the upper part, the spleen is in the middle, and the liver and gallbladder are in the lower part, all blood stasis and qi accumulation, no irregular regulation and smooth. However, Lian Qiao treats blood system and chai Hu treats qi system.
Coix seed: tonifying stomach and spleen, excreting dampness and promoting diuresis, and clearing lung heat; the key herb of Yi ren is indicated for cold due to heat.
Thunberg fritillary bulb: bei mu is bitter in taste and can decrease, while slightly pungent in flavor can dispel the stagnation, so it is used in heart and lung. It is also indicated for flaccid lung, lung abscess, sore throat, goiter, phlegm nodule, carbuncle, cellulitis and sore toxin, all of which have the actions of resolving stagnation, dissipating mass and promoting blood circulation; bei mu is slightly cold, bitter and purging heart fire, pungent and dispersing lung qi stagnation. It has special actions of resolving masses, removing heat and removing malignant sores.
Moutan bark: pungent and cold in flavor. Removing symptoms, and retaining blood stasis in intestines and stomach; the five internal organs are calmed; treating carbuncle sore; pungent and bitter in flavor and cold in flavor. Treating carbuncle swelling, discharging pus and stopping pain; pungent, bitter and slightly cold. It enters Shaoyin and Jueyin of hand and foot. Purging latent fire in blood and dredging meridians. Remove dysphoria with smothery sensation and treat carbuncle and sore.
Selfheal: pungent, bitter and slightly cold, the liver fire is relieved, the internal heat is relieved, and the qi is dispersed; bitter and pungent taste, cold smell, and no toxicity. Mass and hard mass, fistula, tumor and qi stagnation, and scrofula, mice, fistula and head sore. Cold and heat can expel the pathogenic wind and dampness with the syndrome of arthralgia.
Spina gleditsiae: pungent and warm property, the sharp and direct actions on the affected area, ulcerate and abscess. It is a sedative for abscess, deep-rooted carbuncle and ulceration; the medicine is loaded with surgical herbs to treat ulcer directly and successfully.
Dandelion: enter Taiyin and Yangming. It can resolve heat-toxicity, relieve food toxicity, and cure swelling and tuberculosis, and is a good herb for treating mammary abscess and furuncle.
Detailed Description
The present invention will be further illustrated with reference to the following examples.
Example (b):
a traditional Chinese medicine composition for treating facial acne comprises the following raw materials: dandelion, prunella vulgaris, forsythia, spina gleditsiae, thunberg fritillary bulb, coix seed and moutan bark, wherein the traditional Chinese medicine composition at least comprises a traditional Chinese medicine composition for treating forehead acne, one of a traditional Chinese medicine composition for treating acne in two cheek areas or a traditional Chinese medicine composition for treating acne in a mental lower periphery area, and the raw materials of the traditional Chinese medicine composition for treating the forehead acne further comprise loquat leaf, honeysuckle and liquorice; the Chinese medicinal composition for treating acne comprises bupleuri radix, Scutellariae radix, radix Paeoniae Rubra, rhizoma Pinelliae Preparata and Glycyrrhrizae radix; the Chinese medicinal composition for treating acne comprises cortex Phellodendri, rhizoma anemarrhenae and Concha Ostreae. The traditional Chinese medicine composition for treating forehead acne has the effects of clearing lung-heat, cooling heart, promoting diuresis, removing toxicity, removing blood stasis and resolving masses; the traditional Chinese medicine composition for treating the acne on the two cheek parts has the effects of soothing the liver and gallbladder, eliminating dampness and detoxifying, and eliminating stagnation and eliminating the cyst; the traditional Chinese medicine composition for treating the acne around the chin has the effects of clearing kidney fire, detoxifying and eliminating dampness, and resolving masses and eliminating cysts.
The traditional Chinese medicine composition for treating forehead acne is prepared from the following raw materials in parts by weight: 5-15 parts of loquat leaves, 15-45 parts of dandelion, 10-30 parts of honeysuckle, 15-45 parts of coix seeds, 5-15 parts of selfheal, 10-30 parts of fructus forsythiae, 5-15 parts of spina gleditsiae, 5-15 parts of thunberg fritillary bulb, 10-20 parts of moutan barks and 5-10 parts of liquorice; the traditional Chinese medicine composition for treating acne on two cheeks is prepared from the following raw materials in parts by weight: 5-15 parts of radix bupleuri, 15-25 parts of radix scutellariae, 5-15 parts of thunberg fritillary bulb, 10-30 parts of fructus forsythiae, 10-20 parts of moutan bark, 5-15 parts of red peony root, 5-15 parts of rhizoma pinellinae praeparata, 15-45 parts of dandelion, 5-10 parts of liquorice, 15-45 parts of semen coicis, 5-15 parts of spina gleditsiae and 5-15 parts of selfheal; the traditional Chinese medicine composition for treating the submental perioral acne is prepared from the following raw materials in parts by weight: 5 to 15 parts of phellodendron, 5 to 15 parts of rhizoma anemarrhenae, 10 to 45 parts of coix seed, 5 to 15 parts of thunberg fritillary bulb, 5 to 15 parts of selfheal, 15 to 45 parts of dandelion, 5 to 15 parts of spina gleditsiae, 5 to 15 parts of moutan bark, 15 to 30 parts of oyster and 10 to 30 parts of forsythia. According to the distribution of acne on different areas of face, the patient can choose the matching form of different compositions (wherein the weight ratio of the same medicine is only the maximum ratio of one medicine), such as: selecting a traditional Chinese medicine composition for treating the acne on the forehead when the acne exists on the forehead; selecting a traditional Chinese medicine composition for treating acne on two cheek parts when acne exists on the two cheek parts; selecting a traditional Chinese medicine composition for treating acne around the periphery of the submental opening when the periphery of the submental opening has the acne; the forehead and the two cheeks have acnes, the traditional Chinese medicine composition for treating the forehead and the traditional Chinese medicine composition for treating the two cheeks can be used together; the two cheek parts and the periphery of the submental opening have acnes, and the traditional Chinese medicine composition for treating the two cheek parts and the traditional Chinese medicine composition for treating the periphery of the submental opening can be used as a compound prescription; the forehead and the lower chin can have acne, and the traditional Chinese medicine composition for treating the forehead acne and the traditional Chinese medicine composition for treating the periphery of the lower chin can be used together; the three compositions are combined when acne is found on the whole face.
The preparation method of the traditional Chinese medicine composition for treating facial acne comprises the following operation steps:
(1) weighing loquat leaves, dandelion, honeysuckle, coix seeds, selfheal, weeping forsythia, spina gleditsiae, thunberg fritillary bulb, tree peony bark and liquorice according to parts by weight, drying the obtained raw materials, uniformly mixing, grinding into powder, sieving by a 50-100-mesh drug detection sieve to prepare traditional Chinese medicine powder, and sterilizing under an ultraviolet germicidal lamp for 8 hours to obtain an intermediate I;
(2) weighing radix bupleuri, radix scutellariae, thunberg fritillary bulb, fructus forsythiae, moutan bark, red paeony root, rhizoma pinellinae praeparata, dandelion, liquorice, semen coicis, spina gleditsiae and selfheal according to the weight parts, drying the obtained raw materials, uniformly mixing, grinding into powder, sieving by a 50-100-mesh medicine detection sieve to prepare traditional Chinese medicine powder, and sterilizing for 8 hours under an ultraviolet sterilizing lamp to obtain an intermediate II;
(3) weighing cortex Phellodendri, rhizoma anemarrhenae, Coicis semen, Bulbus Fritillariae Thunbergii, Prunellae Spica, herba Taraxaci, spina Gleditsiae, cortex moutan, Concha Ostreae and fructus forsythiae, drying the obtained raw materials, mixing well, grinding into powder, sieving with 50-100 mesh sieve to obtain traditional Chinese medicine powder, and sterilizing under ultraviolet sterilizing lamp for 8h to obtain intermediate III;
(4) mixing one or two or three of the intermediates I, II and III to make into oral preparation.
The oral preparation can be tablet, dispersant, soft capsule, granule, pill, dripping pill, gel and oral liquid.
The process for preparing tablets in oral dosage forms is as follows: selecting one or two or three of the intermediates I, II and III, adding Gypsum Fibrosum powder, common adjuvants and binder, mixing, granulating, drying, adding lubricant, mixing, grading, and tabletting to obtain tablet; the common auxiliary materials are selected from one or a mixture of more than two of starch, powdered sugar, microcrystalline cellulose, inorganic salts and mannitol; the adhesive is one of distilled water or 30-70% ethanol solution; the lubricant is one of 0.1-1% of magnesium stearate, 0.1-3% of talcum powder or 0.1-0.3% of superfine silica gel powder.
The preparation process of the soft capsule in the oral preparation comprises the following steps: selecting one or two or three of the intermediates I, II and III, adding 1-15% of polyethylene glycol, plasticizer, disintegrating agent, curcumin, ferric oxide, wetting agent and suspending agent, mixing well, and filling into soft capsules; the plasticizer is selected from glycerol or polyalcohol; the disintegrating agent is selected from dried starch or effervescent disintegrating agent; the wetting agent is one of 30-70% ethanol or liquid paraffin; the suspending agent is selected from beeswax, aluminum monostearate or ethyl cellulose.
On the basis of ensuring the treatment effect of the original traditional Chinese medicine, the preparation method of the tablet and the soft capsule is provided for the convenience of storage, carrying and taking of patients, the tablet and the soft capsule can be directly taken with water, are safe and sanitary, are convenient to carry and store, are easy to produce and sell, and change the situation that the taking method of the traditional Chinese medicine preparation is complicated. The traditional Chinese medicine composition provided by the invention is reasonable in compatibility, combines the five pathogenies of heat, dampness, toxicity, stasis and stagnation of the facial meridians and viscera, and the prepared special prescription has no side effect, has a good treatment effect on facial acne, can radically cure facial acne without relapse, is simple and practical in treatment, is convenient to popularize and apply, does not need guidance of doctors, and can be mastered by patients.
The traditional Chinese medicine composition disclosed by the invention is subjected to clinical efficacy tracking, and the treatment process and the treatment results are as follows:
1. selecting a patient:
840 cases of face acne patients (with scattered or densely distributed red or light red papules, or red heat swelling and pain, or pustules, such as millet, or white oily substances extruded out, or nodules and cysts with different sizes) are selected, and the patients are randomly selected into a treatment group and a control group according to clinical manifestations; wherein, 60 cases of forehead acne, 60 cases of cheek acne, 60 cases of perimental acne, 60 cases of forehead and submental acne, 60 cases of cheek and submental acne, 60 cases of forehead and cheek acne, 60 cases of whole face acne, 420 cases altogether, adopt corresponding Chinese medicinal composition or Chinese medicinal composition to combine prescription; control group: the rest 420 cases are equally distributed to the same number of people as the treatment group according to the positions of facial acnes, and are treated by five-flavor disinfection drink.
2. The curative effect standard is as follows:
(1) and (3) healing: facial acne disappears or substantially disappears;
(2) the effect is shown: facial acne is reduced by more than 75% compared with that before treatment;
(3) the method has the following advantages: facial acne is reduced by 50-75% compared with that before treatment;
(4) micro-effect: facial acne is reduced by 25-50% compared with that before treatment;
(5) and (4) invalidation: facial acne is reduced by less than 25% compared to the previous.
3. The treatment course is as follows: four weeks is a course of treatment.
4. The treatment effect is as follows: observing the result of a treatment course, and counting the total effective rate according to the micro-effect and the results above the micro-effect.
5. The curative effect of the treatment group and the control group is compared:
(I) comparing the treatment effect of prefrontal acne with that of control group
| Comparison group | Recovery method | Show effect | Is effective | Micro-effect | Invalidation | Total effective rate |
| Treatment group | 50 | 6 | 4 | 0 | 0 | 100% |
| Control group | 20 | 10 | 10 | 10 | 10 | 83.33% |
(II) comparing the curative effect of the two-cheek acne with that of the control group
| Control group classification | Recovery method | Show effect | Is effective | Micro-effect | Invalidation | Total effective rate |
| Treatment group | 48 | 5 | 5 | 2 | 0 | 100% |
| Control group | 11 | 9 | 5 | 15 | 20 | 66.67% |
(III) comparing the curative effect of the peripheral acne under the chin with that of the control group
| Control group classification | Recovery method | Show effect | Is effective | Micro-effect | Invalidation | Total effective rate |
| Treatment group | 50 | 7 | 3 | 0 | 0 | 100% |
| Control group | 9 | 6 | 3 | 5 | 37 | 38.33% |
(IV) comparing the curative effect of the acne on forehead and two cheeks with that of the control group
| Control group classification | Recovery method | Show effect | Is effective | Micro-effect | Invalidation | Total effective rate |
| Treatment group | 45 | 10 | 11 | 4 | 0 | 100% |
| Control group | 8 | 8 | 15 | 5 | 24 | 60% |
(V) comparing the treatment effect of acne around cheek and chin with that of control group
| Control group classification | Recovery method | Show effect | Is effective | Micro-effect | Invalidation | Total effective rate |
| Treatment group | 44 | 11 | 12 | 3 | 0 | 100% |
| Control group | 7 | 7 | 5 | 7 | 34 | 43.33% |
(VI) comparing the curative effects of the acne on the forehead and the periphery of the submental opening with those of the control group
| Control group classification | Recovery method | Show effect | Is effective | Micro-effect | Invalidation | Total effective rate |
| Treatment group | 40 | 10 | 5 | 5 | 0 | 100% |
| Control group | 5 | 5 | 9 | 5 | 36 | 40.00% |
(VII) the curative effect of the whole face acne is compared with that of the control group
| Group of control group | Healing process | Show effect | Is effective | Micro-effect | Invalidation | Total effective rate |
| Treatment group | 38 | 12 | 5 | 5 | 0 | 100% |
| Control group | 4 | 4 | 10 | 5 | 36 | 40.00% |
6. Continued treatment results after one course of treatment in the control group was ineffective:
197 patients in the control group are invalid after one treatment course, and then the traditional Chinese medicine composition or the traditional Chinese medicine composition prescription disclosed by the invention is completely changed, namely the treatment scheme is completely changed. After a treatment course (4 weeks), 131 cases (66.5 percent), 45 cases (22.84 percent), 11 cases (5.6 percent), 10 cases (5.0 percent), and no effect (O cases) are cured, and the total effective rate is 100 percent.
Application example 1
Xue, woman, age 32, clerk. The patient has face acne for 3-4 years, has been treated in many hospitals, is used for antibiotics, vitamin A acid medicines and traditional Chinese medicine decoction, has no obvious effect, and is treated at our station. Facial acne is localized to the forehead and cheeks and aggravated anteriorly. Acne, pimple, and a few nodules and cysts are the main reasons. The traditional Chinese medicine composition for treating forehead and two cheek acnes is given, the re-diagnosis is carried out after two weeks, the facial acnes are reduced by more than 80 percent compared with those before the treatment, and the facial acnes disappear after the treatment is given for two weeks and the third re-diagnosis. The follow-up visit is five years without relapse.
Application example 2
Zhou somewhat, women, 26 years old, workers. The facial acne of a patient is treated by combining traditional Chinese medicine and western medicine in a plurality of hospitals for 1 year, does not improve, is gradually aggravated, and is called by friends to see a doctor at our station. Acne, red comedo, papule, pustule and cyst nodule are all covered on the whole face, and the five-flavor disinfection drink is given for two weeks, so that the double diagnosis is invalid. The three traditional Chinese medicine composition are used for treating two weeks instead, the facial acne in the three diagnosis cases is reduced by about 70 percent compared with the facial acne in the previous two weeks, the facial acne basically disappears after the previous two weeks, and the treatment of attacking and consolidating is performed for one week. The disease does not relapse after five years of follow-up.
The above description is provided for the purpose of describing the preferred embodiments of the present invention in more detail, and it should not be construed that the embodiments of the present invention are limited to the description above, and it will be apparent to those skilled in the art that the present invention can be implemented in many different forms without departing from the spirit and scope of the present invention.
Claims (5)
1. A traditional Chinese medicine composition for treating facial acne is characterized in that: the traditional Chinese medicine composition at least comprises one of a traditional Chinese medicine composition for treating forehead acne, a traditional Chinese medicine composition for treating two cheek acnes or a traditional Chinese medicine composition for treating submental perioral acne; the traditional Chinese medicine composition for treating forehead acne is prepared from the following raw materials in parts by weight: 5-15 parts of loquat leaves, 15-45 parts of dandelion, 10-30 parts of honeysuckle, 15-45 parts of semen coicis, 5-15 parts of selfheal, 10-30 parts of fructus forsythiae, 5-15 parts of spina gleditsiae, 5-15 parts of thunberg fritillary bulb, 10-20 parts of moutan bark and 5-10 parts of liquorice; the traditional Chinese medicine composition for treating acne on two cheeks is prepared from the following raw materials in parts by weight: 5-15 parts of radix bupleuri, 15-25 parts of radix scutellariae, 5-15 parts of thunberg fritillary bulb, 10-30 parts of fructus forsythiae, 10-20 parts of moutan bark, 5-15 parts of red peony root, 5-15 parts of rhizoma pinellinae praeparata, 15-45 parts of dandelion, 5-10 parts of liquorice, 15-45 parts of semen coicis, 5-15 parts of spina gleditsiae and 5-15 parts of selfheal; the traditional Chinese medicine composition for treating the submental perioral acne is prepared from the following raw materials in parts by weight: 5 to 15 parts of phellodendron, 5 to 15 parts of rhizoma anemarrhenae, 10 to 45 parts of coix seed, 5 to 15 parts of thunberg fritillary bulb, 5 to 15 parts of selfheal, 15 to 45 parts of dandelion, 5 to 15 parts of spina gleditsiae, 5 to 15 parts of moutan bark, 15 to 30 parts of oyster and 10 to 30 parts of forsythia.
2. A method of preparing a traditional Chinese medicine composition for treating facial acne as claimed in claim 1, characterized by: the method comprises the following steps:
weighing loquat leaves, dandelion, honeysuckle, coix seeds, selfheal, fructus forsythiae, spina gleditsiae, thunberg fritillary bulb, moutan bark and liquorice according to the parts by weight, drying the obtained raw materials, uniformly mixing, grinding into powder, sieving by a 50-100-mesh drug sieve to prepare traditional Chinese medicine powder, and sterilizing for 8 hours under an ultraviolet germicidal lamp to obtain an intermediate I;
weighing radix bupleuri, radix scutellariae, thunberg fritillary bulb, fructus forsythiae, moutan bark, red paeony root, rhizoma pinellinae praeparata, dandelion, liquorice, semen coicis, spina gleditsiae and selfheal according to the weight parts, drying the obtained raw materials, uniformly mixing, grinding into powder, sieving by a 50-100-mesh medicine detection sieve to prepare traditional Chinese medicine powder, and sterilizing for 8 hours under an ultraviolet sterilizing lamp to obtain an intermediate II;
weighing cortex Phellodendri, rhizoma anemarrhenae, Coicis semen, Bulbus Fritillariae Thunbergii, Prunellae Spica, herba Taraxaci, spina Gleditsiae, cortex moutan, Concha Ostreae and fructus forsythiae, drying the obtained raw materials, mixing well, grinding into powder, sieving with 50-100 mesh sieve to obtain traditional Chinese medicine powder, and sterilizing under ultraviolet sterilizing lamp for 8h to obtain intermediate III;
mixing one or two or three of the intermediates I, II and III to make into oral preparation.
3. The preparation method of the traditional Chinese medicine composition for treating facial acne as claimed in claim 2, characterized in that: the oral preparation is tablet, dispersant, soft capsule, granule, pill, gel or oral liquid.
4. The preparation method of the traditional Chinese medicine composition for treating facial acne as claimed in claim 3, characterized in that: the preparation process of the tablet in the oral preparation is as follows: selecting one or two or three of the intermediates I, II and III, adding Gypsum Fibrosum powder, common adjuvants and binder, mixing, granulating, drying, adding lubricant, mixing, grading, and tabletting to obtain tablet; the common auxiliary materials are selected from one or a mixture of more than two of starch, powdered sugar, microcrystalline cellulose, inorganic salts and mannitol; the adhesive is one of distilled water or 30-70% ethanol solution; the lubricant is one of 0.1-1% of magnesium stearate, 0.1-3% of talcum powder or 0.1-0.3% of superfine silica gel powder.
5. The preparation method of the traditional Chinese medicine composition for treating facial acne as claimed in claim 3, characterized in that: the preparation process of the soft capsule in the oral preparation is as follows: selecting one or two or three of the intermediates I, II and III, adding 1-15% of polyethylene glycol, plasticizer, disintegrating agent, curcumin, ferric oxide, wetting agent and suspending agent, mixing well, and filling into soft capsules; the plasticizer is selected from glycerol or polyalcohol; the disintegrating agent is one of dry starch or effervescent disintegrating agent; the wetting agent is one of 30-70% ethanol or liquid paraffin; the suspending agent is selected from one of beeswax, aluminum monostearate or ethyl cellulose.
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| CN103055116A (en) * | 2012-11-25 | 2013-04-24 | 荣成市崖头美全口腔诊所 | Traditional Chinese medicine composition for treating acnes |
| CN104587198A (en) * | 2014-12-29 | 2015-05-06 | 辛怡静 | Traditional Chinese medicine composition for treating acne |
| CN105362822A (en) * | 2015-12-22 | 2016-03-02 | 徐士杰 | Medicine for treating acne and preparation method thereof |
| CN108126059A (en) * | 2018-02-02 | 2018-06-08 | 上海荷本生物科技有限公司 | A kind of Chinese medicine composition for treating acne and preparation method thereof |
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| CN109700945A (en) * | 2018-11-16 | 2019-05-03 | 江苏医药职业学院 | A kind of Chinese medicine composition for treating mild acne |
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| CN103055116A (en) * | 2012-11-25 | 2013-04-24 | 荣成市崖头美全口腔诊所 | Traditional Chinese medicine composition for treating acnes |
| CN104587198A (en) * | 2014-12-29 | 2015-05-06 | 辛怡静 | Traditional Chinese medicine composition for treating acne |
| CN105362822A (en) * | 2015-12-22 | 2016-03-02 | 徐士杰 | Medicine for treating acne and preparation method thereof |
| CN108126059A (en) * | 2018-02-02 | 2018-06-08 | 上海荷本生物科技有限公司 | A kind of Chinese medicine composition for treating acne and preparation method thereof |
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