CN105193686B - A kind of Feminine care solution and preparation method thereof - Google Patents
A kind of Feminine care solution and preparation method thereof Download PDFInfo
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- CN105193686B CN105193686B CN201510588878.6A CN201510588878A CN105193686B CN 105193686 B CN105193686 B CN 105193686B CN 201510588878 A CN201510588878 A CN 201510588878A CN 105193686 B CN105193686 B CN 105193686B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The present invention relates to a kind of Feminine care solution, the preparation method of the Feminine care solution is further related to.The Feminine care solution contains propolis extract, collagen liquid, aloe extract, mint extract, pectin solution, hyalomitome acid solution, pyrrolidone sodium carboxylate and anesin preservative etc..The Feminine care solution of the present invention is free of chemical bacteriostatic agent, has no toxic side effect, propolis active ingredients have inhibitory action to vagina harmful bacteria; there is protective effect to beneficial bacterium simultaneously, vagina normal flora balance is kept, Feminine care solution ethanol content of the invention is low; have no stimulation, product is stable.
Description
【Technical field】
The invention belongs to human body cosmetic nursing technique field.More particularly it relates to which a kind of Feminine care solution, is also related to
And the preparation method of the Feminine care solution.
【Background technology】
In the vagina of women, a variety of different floras of living always are needed in addition to protentomon, fungi, in addition to a lot
Oxygen bacterium and anaerobic bacteria, these microorganisms can be divided into commensalism microorganism and pathologic microorganism, have antagonism between them.Just
In the case of often, Bacillus acidi lactici is in occupation of leading position, and it is a kind of beneficial bacterium, can then make the moon by decomposition of glycogen into lactic acid
Environment is in faintly acid in road, so as to suppress the growth reproduction of other pathogenic bacteria such as mould, maintains vaginal flora balance, is unlikely to draw
Send out disease.But, vaginal environment be often subject to itself product of host metabolism product, bacterium and extrinsic factor (sexual intercourse, with alkalescence
Shower cream or clear water are rinsed) and it is unstable.Bacterial vaginosis BV is due to ability of Lactobacillus in human vagina reduction and other bacteriums are a large amount of
Breeding is caused a disease.In order to prevent various vaginitis, people usually using medicine font size, disappear font size or adornment font size washing lotion, disinfection pad etc.,
And the main active of these conditioning liquids is mostly chlorhexidine, chlorhexidine has broad-spectrum sterilization, bacteriostasis, including leather
Blue positive and negative bacterium, fungi and some viruses.Using destructible vaginal flora environment during these conditioning liquids, together with beneficial
Fungal component is also killed, the balance between destruction intravaginal microorganism, and then triggers or aggravate various colpitis, therefore, finds
Pure natural vaginal care product is the trend of future development.
Unique flavonoids of propolis, terpenoid substance for various bacteria, fungi, virus and parasite etc. have suppression and
Killing action, some results of study show that propolis is to vaginitis such as trichomonas vaginalis, staphylococcus aureus, Candida albicans
Disease has certain effect.Moreover, the beneficial microbe of intravaginal is based on lactobacillus, research shows propolis to bifid in yoghurt
Bacillus and lactic acid bacteria are substantially without influence.Therefore, propolis is applied in vagina care product, it will help suppress pernicious bacteria
Without killing beneficial group, beneficial to maintenance normal flora environment.
Aloe contains tinctura aloes, and it is antibiotic property very strong material, can kill the germs such as fungi, mould, bacterium, virus,
Suppress and the development of eliminating pathogen is bred.Aloe also contains aloe polysaccharide, and it can strengthen resistance of the human body to disease, cures
The inflammation such as dermatitis, vaginitis.
The principal component of peppermint is menthol, and it can locally control itch, also with pleasantly cool sense.
In order to overcome the drawbacks of being brought using antibiotic as bactericide more than existing Feminine care solution, the present inventor is total
Tie on the basis of prior art, by lot of experiments and interpretation of result, the present invention is completed finally, one kind is provided for women
Daily nursing product for vulva position.
【The content of the invention】
[technical problem to be solved]
It is an object of the invention to provide a kind of Feminine care solution.
It is a further object to provide the preparation method of the Feminine care solution.
[technical scheme]
The present invention is achieved through the following technical solutions.
The present invention relates to a kind of preparation method of Feminine care solution.
The step of feminine care liquid and preparation method thereof of the present invention, is as follows：
A, propolis liquid preparation
According to the ratio 1 of propolis in gram and the absolute ethyl alcohol in terms of milliliter：3~5, make propolis super with absolute ethyl alcohol at room temperature
Sound wave extracts 20~30min, then isolated extract solution E1With extracting residue R1；
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：2~4, allow and extract residue R1With dense
80~90% ethanol water 25~35min of ultrasonic wave extraction by volume is spent, then isolated extract solution E2It is residual with extracting
Excess R2；
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：1~3, allow and extract residue R2With dense
50~60% ethanol water 30~40min of ultrasonic wave extraction by volume is spent, then isolated extract solution E3It is residual with extracting
Excess R3；
By extract solution E1, extract solution E2With extract solution E3Merge；The extract solution of merging is then put in the refrigerator of 4 DEG C of temperature
A night paraffin removal is put, refrigerator is then removed, allows the extract solution of paraffin removal to be warming up to room temperature, rotary evaporation concentration is then carried out, obtains honeybee
Glue extract concentrations are in mass 30~40% propolis extract；
B, preparation raw material solution
Collagen is dissolved in distilled water in mass 5~10% according to concentration, a kind of collagen liquid is made；
According to concentration 3~8% pectin to be dissolved in mass in distilled water, then with lactic acid by the pH of resulting solution
Value regulation obtains a kind of pectin solution to 3.8~4.2；
According to concentration 4.8~5.2% hyaluronic acid powder to be added in mass in distilled water, heated under temperature 50 C
Fully dissolving, is made a kind of hyaluronic acid solution；
C, preparation
Under agitation, 5~10 parts by weight are added to 0.5~3.0 parts by weight in step in the obtained propolis extracts of step A
In the collagen liquid that B is obtained, 0.5~3.0 parts by weight aloe extract and 0.1~0.5 parts by weight peppermint are then sequentially added
Extract, is well mixed, then its mixture is added in 1~3 obtained parts by weight pectin solutions of step B and 0.1~2.0 weight
Measure in part hyalomitome acid solution, be uniformly mixed, add 2~15 parts by weight pyrrolidone sodium carboxylates and 0.01~1.0 weight
Portion preservative and the distilled water that total amount is 100 parts by weight is supplemented to, mixes, obtain described Feminine care solution.
A preferred embodiment of the invention, in step, described rotary evaporation concentration be temperature 45~
Carried out under the conditions of 60 DEG C.
According to another preferred embodiment of the present invention, in stepb, the concentration of the lactic acid be in mass 75~
85%.
According to another preferred embodiment of the present invention, in stepb, the molecular weight of the hyaluronic acid is 400,000~
1000000 Da.
According to another preferred embodiment of the present invention, in step C, described preservative is selected from Phenoxyethanol, benzene
Formic acid, phenmethylol or anesin.
According to another preferred embodiment of the present invention, in step C, pyrrolidone sodium carboxylate and preservative are being added
Add again afterwards in terms of Feminine care solution gross mass 0.01~0.1% amphoteric surfactant or nonionic surfactant.
According to another preferred embodiment of the present invention, described amphoteric surfactant is selected from dodecanamide propyl sweet tea
Dish alkali, Cocoamidopropyl betaine, dodecyl alanine, lauryl both sexes sodium acetate, Coconut Fatty Acid Monoethanolamide or
Lecithin；Described nonionic surfactant is selected from polyoxyethylene sorbitan monolaurate, polyoxyethylene mountain
Pears alcohol monopalmitate, polyethenoxy sorbitan monostearate or polyethylene glycol.
According to another preferred embodiment of the present invention, in step C, pyrrolidone sodium carboxylate and preservative are being added
Add again afterwards in terms of Feminine care solution gross mass 0.1~0.4% foaming agent.
According to another preferred embodiment of the present invention, described foaming agent is coconut oil foaming agent or amino acid foaming
Agent.
The invention further relates to the Feminine care solution prepared using the preparation method.
Described Feminine care solution contain 1.5~4.0 parts by weight propolis extracts, 0.03~3.0 parts by weight collagen,
0.5~3.0 parts by weight aloe extract, 0.1~0.5 parts by weight mint extract, 0.03~0.24 parts by weight pectin, 0.005
~1.04 parts by weight hyaluronic acids, 2~15 parts by weight pyrrolidone sodium carboxylates, 0.01~1.0 parts by weight preservative, 0.0~
0.40 parts surfactant and 0.0~0.80 parts by weight foaming agent and be supplemented to total amount be 100 parts by weight distilled water.
The present invention is described in more detail below.
The present invention Feminine care solution be one kind collect cleaning, it is antibacterial, safeguard privates colony balance and nursing reparation effect in
The pure natural Feminine care solution of one, it can be used for daily privates nursing maintenance independent of bactericide.
The present invention overcomes the conventional bacteriostatic agent of propolis generally to use ethanol for solvent, and thus generation is easily precipitated, excitant is strong, production
The technological deficiency such as product are unstable is there is provided one kind by propolis, collagen, aloe, peppermint, hyaluronic acid, lactic acid and other additions
The non-stimulated of agent composition, performance stabilization, safe and reliable Feminine care solution.
The present invention relates to a kind of preparation method of Feminine care solution.
The step of feminine care liquid and preparation method thereof of the present invention, is as follows：
A, propolis liquid preparation
According to the ratio 1 of propolis in gram and the absolute ethyl alcohol in terms of milliliter：3~5, make propolis super with absolute ethyl alcohol at room temperature
Sound wave extracts 20~30min, then isolated extract solution E1With extracting residue R1；
Propolis is the resin that honeybee gathers from plant gemma or trunk, and by its resin and upper palatine gland and wax gland secretion
The colloidal solid thing with aromatic odor that hybrid process is obtained.The most important active material of propolis is to belong to flavone compound
Quercetin, terpene, organic acid, alcohol, phenol, aldehyde, ketone, ester, ether compound, enzyme and inorganic salts etc..
In this step, that propolis is crushed into granularity using pulverizer usually used in processing technique of Chinese herbs field is small
In 100 mesh.The propolis that the present invention is used is the product sold extensively in the market.
It is raw that the purpose that the step extracts propolis using absolute ethyl alcohol is to extract the flavonoids and phenolic acid class in propolis etc.
Thing active component.
In this step, if the ratio of propolis and absolute ethyl alcohol is more than 1：3, then solution cause active component to extract very little
It is insufficient, and concentration is too high, it is difficult to filter；If the ratio of propolis and absolute ethyl alcohol is less than 1：5, then ethanol consumption is too many, makes
Into waste, also trouble is caused for subsequent concentration process；Therefore, the ratio of propolis and absolute ethyl alcohol is 1：3~5 be it is appropriate, preferably
Ground is 1：3.4~4.5, more preferably 1：3.8~4.0.
The step uses the separation equipment in usual chemical technology field, and such as funnel, filtration gauze or ultrasonic wave are clear
Device is washed, the isolated extract solution E of mixed system will be extracted1With extracting residue R1.Extract solution E1Retain, extract residue R1Again
Carry out subsequent extracted.
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：2~4, allow and extract residue R1With dense
80~90% ethanol waters extract 25~35min to degree by volume, then isolated extract solution E2With extracting residue R2；
The step extracts residue R using 80~90% ethanol waters1Purpose be extract propolis in can not or
It is partially dissolved in the bigger active material of the polarity of absolute ethyl alcohol.
The step using the concentration of ethanol water more than 80~90% when can not then extract and can not or be partly dissolved
In the bigger active material of the polarity of absolute ethyl alcohol, while causing absolute ethyl alcohol to waste, increase cost.
In this step, if extracting residue R1It is more than 1 with the ratio of 80~90% ethanol waters：2, then it can not fill
Divide and extract active material；If extracting residue R1It is less than 1 with the ratio of 80~90% ethanol waters：4, then ethanol consumption is too
It is many, cause to waste, also cause trouble for subsequent concentration process；Therefore, residue R is extracted1With 80~90% ethanol waters
Than for 1：2~4 be it is appropriate, preferably 1：2.4~3.6, more preferably 1：2.8~3.2.
The separation equipment that the step is used with it is previously described identical, will not be repeated here.Residue R will be extracted1Carry
Take the isolated extract solution E of system2With extracting residue R2.Extract solution E2Retain, extract residue R2Subsequent extracted is carried out again.
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：1~3, allow and extract residue R2With dense
50~60% ethanol waters extract 30~40min to degree by volume, then isolated extract solution E3With extracting residue R3；
The step extracts residue R using 50~60% ethanol waters2Purpose be extract propolis in polarity compared with
Big active material.
The step using the concentration of ethanol water more than 50~60% when then can not fully to extract polarity big
Active material, while causing ethanol to waste, increases cost.
In this step, if extracting residue R1It is more than 1 with the ratio of 50~60% ethanol waters：2, then it can not fill
Divide and extract active material；If extracting residue R1It is less than 1 with the ratio of 50~60% ethanol waters：3, then ethanol consumption is too
It is many, cause to waste, also cause trouble for subsequent concentration process；Therefore, residue R is extracted1With 50~60% ethanol waters
Than for 1：1~3 be it is appropriate, preferably 1：1.4~2.6, more preferably 1：1.6~2.2.
The separation equipment that the step is used with it is previously described identical, will not be repeated here.Residue R will be extracted2Carry
Take the isolated extract solution E of system3With extracting residue R3.Extract solution E3Retain, extract residue R3Discard.
By extract solution E1, extract solution E2With extract solution E3Merge；The extract solution of merging is then put in the refrigerator of 4 DEG C of temperature
A night paraffin removal is put, refrigerator is then removed, allows the extract solution of paraffin removal to be warming up to room temperature, rotary evaporation concentration is then carried out, obtains honeybee
Glue extract concentrations are in mass 30~40% propolis extract；
The effect of this paraffin removal is the recovery rate for improving propolis effective active composition, increases the steady of propolis extract system
It is qualitative.
In this step, rotary evaporation concentration is carried out using a kind of rotary evaporator system.This rotary evaporator system
System can be being vacuumized with evaporating solvent under conditions of 20~200 revs/min of rotating speed, and solution is concentrated.What the present invention was used
Rotary evaporator system is the product sold in the market, such as by Shanghai Yarong Biochemical Instrument Plant with trade name rotary evaporation
The product of device sale.
In this step, the rotary evaporator system that uses of the present invention preferably vacuumizing, 45~60 DEG C of temperature
With carrying out rotary evaporation concentration under conditions of 80~150 revs/min of rotating speed, until the 20~30% of original mixture volume.
The propolis extract that rotary evaporation is concentrated to give is tested at ambient temperature using spectrophotometric method
Analysis, it is determined that propolis extract is mainly flavonoids and phenolic acid compound in the propolis extract, and with these propolis
It is in mass 30~40% that extractive content, which calculates its concentration,.
B, preparation raw material solution
I, according to concentration 5~10% collagen to be dissolved in mass in distilled water, a kind of collagen liquid is made.
Collagen is a kind of structural protein of extracellular matrix, is a kind of macromolecular egg of generally existing in animal body
In vain, it is primarily present in the connective tissue of animal (bone, cartilage, skin, tendon, tough etc.), because it has good bio-compatible
Property, biodegradable and bioactivity, be easily absorbed by the body in vivo, cellular activities and growth can be promoted, promote blood small
Plate condensation etc., so being widely applied in fields such as food, medicine, organizational project, cosmetics.
In conditioning liquid of the present invention, the specific effect of collagen is compound with the propolis active factor, increases propolis active
The water solubility of the factor, at the same can Glycerin, assign its and smooth feel.
The collagen that the present invention is used is the product sold in the market, and for example by Henan, just emerging food additives have
The product that limit company is sold with trade name Isin glue collagen.
II, according to concentration 3~8% pectin to be dissolved in mass in distilled water, then with lactic acid by resulting solution
PH value adjust to 3.8~4.2, obtain a kind of pectin solution.
Natural fruit gelatin substance be with protopectin, pectin, pectic acid form be widely present in the fruit of plant, root, stem,
Ye Zhong, is a kind of constituent of cell membrane, they exist with cellulose, constitutes flanking cell interlayer cohesive thing, makes
Plant tissue cell is tightly bonded together.Protopectin is insoluble in the material of water, but in the chemical reagent such as acid, alkali, salt and enzyme
In the presence of, hydrolyzable is transformed into water soluble pectin.Therefore, concentration of the present invention is in mass 75~85% breast
Acid, the pH value of resulting solution is adjusted to 3.8~4.2, obtains a kind of pectin solution.
In conditioning liquid of the present invention, the specific effect of pectin is active component in stable emulsifying propolis.
The pectin that the present invention is used is the product sold in the market, such as by the limited public affairs of Henan Jin Run food additives
Take charge of the product sold with trade name pectin.
III, according to concentration 4.8~5.2% hyaluronic acid powder to be added in mass in distilled water, under temperature 50 C
Heating fully dissolving, is made a kind of hyaluronic acid solution.
Hyaluronic acid is a kind of acid mucopolysaccharide, is made up of D-Glucose aldehydic acid and N-acetyl-glucosamine, and it is unique with it
Molecular structure and physicochemical property show important physiological function in body, such as lubricating joint, regulation Vascular Permeability,
Regulatory protein matter, water, electrolyte diffusion and operating etc., especially with fabulous water retention property.
In conditioning liquid of the present invention, the specific effect of hyaluronic acid is to improve vagina local microenvironment, improves vagina epithelium
Repair ability, effectively alleviate vaginal atrophy.
According to the present invention, the molecular weight of the hyaluronic acid is preferably 40~1,000,000 Da.
The hyaluronic acid that the present invention is used is the product sold in the market, and for example by Xi'an, asparagus fern biotechnology is limited
The product that company of company is sold with trade name Sodium Hyaluronate.
C, preparation
Under agitation, 5~10 parts by weight are added to 0.5~3.0 parts by weight in step in the obtained propolis extracts of step A
In the collagen liquid that B is obtained, 0.5~3.0 parts by weight aloe extract and 0.1~0.5 parts by weight peppermint are then sequentially added
Extract, is well mixed, then its mixture is added in 1~3 obtained parts by weight pectin solutions of step B and 0.1~2.0 weight
Measure in part hyalomitome acid solution, be uniformly mixed, add 2~15 parts by weight pyrrolidone sodium carboxylates and 0.01~1.0 weight
Portion preservative and the distilled water that total amount is 100 parts by weight is supplemented to, mixes, obtain described Feminine care solution.
Aloe extract contains leaf Cai containing reed glucoside, isobarbaloin, β-barbaloin, aloe-emodin and aloe glucoside A, B etc.
Active component.It, which has, makes skin contraction, softness, moisturizing, anti-inflammatory, the performance of bleaching.
In conditioning liquid of the present invention, the specific effect of aloe extract is that suppression and the development of elimination vaginal pathogens are numerous
Grow.
The aloe extract that the present invention is used is the product sold in the market, and for example by Xi'an, Tian Feng biotechnologies have
The product that limit company is sold with trade name aloe extract.
Mint extract contains menthyl acetate, amphene, limonene, isomenthone, firpene, piperitenone, resin and lacked
Tannin, Rosmarinic acid etc. are measured, it has antivirus action, analgesia, itching-relieving action, anti-irritant, antitussive action, bactericidal action and profit
Courage effect etc..
In conditioning liquid of the present invention, the specific effect of mint extract is that part controls itch, also with pleasantly cool sense.
The mint extract that the present invention is used is the product sold in the market, for example, opened by Hunan through continent plant resources
The product that hair Co., Ltd is sold with trade name mint extract.
Pyrrolidone sodium carboxylate (PCA-Na) is naturally occurring material in skin, is amino acid derivativges, and itself is molten
In water and ethanol, but insoluble in oil, with stronger hygroscopicity, moisture content can also be absorbed from air, it is in cosmetics
Used as NMF, its moisture-retaining capacity is stronger than glycerine, propane diols, sorbierite.
In conditioning liquid of the present invention, the specific effect of pyrrolidone sodium carboxylate is moisturizing, lubrication vagina.
The pyrrolidone sodium carboxylate that the present invention is used is the product sold in the market, for example, beat up Peng Teke by Shenzhen
Skill Co., Ltd is with trade name Japan aginomoto NL-50 and by Guangzhou Zhu Feng foreign trades Co., Ltd with trade name NL-50
The product of pyrrolidone sodium carboxylate sale.
Generally all contain some nutritional ingredients in cosmetics, some preservatives are added in cosmetics, to suppress bacterium
Growth, it is to avoid cosmetics produce denaturalization phenomenon, maintains freshness and lasting effect.
In conditioning liquid of the present invention, the specific effect of preservative is the growth and breeding for suppressing microorganism in product, due to
This product itself has stronger antiseptic power, therefore can be not added with or add on a small quantity.
According to the present invention, described preservative is selected from Phenoxyethanol, sodium benzoate, phenmethylol or anesin.
The preservative that the present invention is used is the product sold in the market, for example, imported and exported by the native chemical industry in Shanghai east limited
Company is with Phenoxyethanol trade name and the product sold by Lu Ke chemical industry Co., Ltd of Shouguang City with trade name sodium benzoate；
By Guangzhou Hui Xiang Chemical Co., Ltd.s with trade name phenmethylol and Nanjing chemical reagent limited company with trade name trichlorine
The product of tert-butyl alcohol sale.
In order to improve the Feminine care solution performance of the present invention, the effect of the Feminine care solution is given full play to, in the present invention
Feminine care solution in can also add surfactant and foaming agent.
Can again be added after pyrrolidone sodium carboxylate and preservative is added 0.01 in terms of Feminine care solution gross mass~
0.1% amphoteric surfactant or nonionic surfactant.
Surfactant is that a class can reduce surface tension of liquid, or liquid-liquid, the compound of liquid-solid interface tension force.
It is that a class has fixed hydrophilic lipophilic group, can be aligned on the surface of solution, and can be remarkably decreased surface tension
Material.
In conditioning liquid of the present invention, the specific effect of surfactant is reduction propolis viscosity, increases dissolubility, makes product
The effect more lubricated.Therefore, the present invention can use amphoteric surfactant and nonionic surfactant.
Described amphoteric surfactant is selected from lauroylamidopropyl betaine, Cocoamidopropyl betaine, dodecane
Base alanine, lauryl both sexes sodium acetate, Coconut Fatty Acid Monoethanolamide or lecithin；
The amphoteric surfactant that the present invention is used all is the product sold in the market, such as by Suzhou source Tai Runization
Work Co., Ltd is with trade name lauroylamidopropyl betaine and by Shanghai Yin Cong new materials Science and Technology Ltd. with trade name coconut palm
The product of oleic monoethanolamide sale.
Described nonionic surfactant is selected from polyoxyethylene sorbitan monolaurate, polyoxyethylene mountain
Pears alcohol monopalmitate, polyethenoxy sorbitan monostearate or polyethylene glycol.
The nonionic surfactant that the present invention is used all is the product sold in the market, such as by Ao highland barley new materials
Scientific and technological (Shanghai) Co., Ltd. with trade name polyethenoxy sorbitan monopalmitate with it is limited by SED's chemical industry (Nantong)
The product that company is sold with trade name polyethylene glycol.
According to the present invention, in this step, add and protected with women again after pyrrolidone sodium carboxylate and preservative is added
Manage the foaming agent of liquid gross mass meter 0.1~0.2%.
Foaming agent is a kind of surface reactive material, and it mainly reduces interfacial tension on gas-water interface, promotes air to exist
Minute bubbles are formed in slurry, expand different alternate contact interfaces, and ensure that bubble rises to form froth bed.
The foaming agent that the present invention is used is coconut oil foaming agent or amino acid foaming agent.
The foaming agent that the present invention is used all is the product sold in the market, and for example by Guangdong, product ancient cooking vessel chemical science and technology is limited
Company is with trade name coconut oil foaming agent and the production sold by Guangzhou Wen Ling trade Co., Ltds with trade name amino acid foaming agent
Product.
The invention further relates to the Feminine care solution prepared using the preparation method.
Described Feminine care solution contain 1.5~4.0 parts by weight propolis extracts, 0.03~3.0 parts by weight collagen,
0.5~3.0 parts by weight aloe extract, 0.1~0.5 parts by weight mint extract, 0.03~0.24 parts by weight pectin, 0.005
~1.04 parts by weight hyaluronic acids, 2~15 parts by weight pyrrolidone sodium carboxylates, 0.01~1.0 parts by weight preservative, 0.0~
0.40 parts surfactant and 0.0~0.80 parts by weight foaming agent and be supplemented to total amount be 100 parts by weight distilled water.
The performance of Feminine care solution prepared by the present invention has carried out following project testing：
A, performance I antiinflammatory actions
Method：Using paraxylene induced mice auricular concha oedema as inflammatory model.32 Kunming mouses are randomly divided into 4
Group, be respectively:
1st, Normal group, gavage gives distilled water 0.1ml/10g body weight；
2nd, model control group, gavage gives distilled water 0.1ml/l0g body weight；
3rd, three hydrogen dihydroxy diphenyl ether group, gavage gives suspension 0.1ml/10g body weight；
4th, Feminine care solution sample sets of the present invention, gavage gives Feminine care solution sample 0.1ml/10g body weight of the present invention；
Successive administration two days, in the auris dextra that paraxylene 0.05ml is equably coated on to mouse after last dose 1h,
Miking auricular concha thickness is used after 4h.
B, performance II itching-relieving actions
Method：24 cavys are randomly divided into 3 groups, are respectively：
1st, control group；
2nd, Triclosan group (0.2%, 0.1mg/100g)；
3rd, Feminine care solution sample sets (0.1ml/100g) of the present invention；
Proxima luce (prox. luc) is tested, to instep shaving behind each group cavy right side.Control group gives equivalent distilled water.10 points after last dose
Clock, starts in surface of a wound Chu Di 0.01% histamine phosphate 0.05ml/ only, hereafter every 3 minutes successively with 0.01%, 0.02%,
0.03%th, 0.04% increasing concen-trations, are 0.05%ml/ every time, turn one's head to lick right metapedes until there is cavy, to there is cavy
When later licking foot to histamine total amount be itch-threshold.
The Feminine care solution of the present invention contains propolis extract, aloe extract, collagen, mint extract and mainly lived
Property composition and hyaluronic acid, pyrrolidone sodium carboxylate, they can nutrition and lubrication vagina, both can clean and kill and be harmful
Bacterium, can maintain weakly acidic condition and profitable strain environment again.
Compared with existing Feminine care solution, Feminine care solution of the invention has following features：
1st, without chemical bacteriostatic agent, have no toxic side effect.
2nd, propolis is used for main active, its inhibitory action to vagina harmful bacteria is given full play to, while to beneficial
Bacterium has protective effect, keeps vagina normal flora balance.
3rd, ethanol content is low in propolis conditioning liquid, has no stimulation, and products obtained therefrom is stable.
[beneficial effect]
The beneficial effects of the invention are as follows：
The Feminine care solution that the present invention is prepared using pure natural Chinese herbal medicine is free of chemical bacteriostatic agent, has no toxic side effect.This hair
It is bright to use propolis for main active, its inhibitory action to vagina harmful bacteria is given full play to, is protected while having to beneficial bacterium
Shield is acted on, and keeps vagina normal flora balance.Ethanol content is low in propolis extract prepared by the present invention, has no stimulation, institute
Obtain product stable.
【Embodiment】
The present invention is will be better understood that by following embodiments.
Embodiment 1：The preparation of Feminine care solution
The implementation steps of the embodiment are as follows：
A, propolis liquid preparation
According to the ratio 1 of propolis in gram and the absolute ethyl alcohol in terms of milliliter：3.0, allow propolis to be carried at room temperature with absolute ethyl alcohol
30min is taken, then isolated extract solution E1With extracting residue R1；
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：2.0, allow and extract residue R1Use concentration
90% ethanol water extracts 28min by volume, then isolated extract solution E2With extracting residue R2；
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：1.6, allow and extract residue R2Use concentration
50% ethanol water extracts 40min by volume, then isolated extract solution E3With extracting residue R3；
By extract solution E1, extract solution E2With extract solution E3Merge；The extract solution of merging is then put in the refrigerator of 4 DEG C of temperature
Put a night paraffin removal, then remove refrigerator, allow the extract solution of paraffin removal to be warming up to room temperature, then pressure 520mmHg, temperature 45 C with
The 30% of original mixture volume is concentrated into carry out rotary evaporation under conditions of 80 revs/min of rotations of rotating speed, a kind of propolis is obtained and carries
Take liquid, the method described using present specification, which is determined, to be determined, in the propolis extract propolis extract concentration be with
Quality meter 32%；
B, preparation raw material solution
Will be by Henan Zheng Xing food additives Co., Ltd with trade name Isin glue collagen in mass 5% according to concentration
The collagen of sale is dissolved in distilled water, and a kind of collagen liquid is made；
It is that 6% will be sold in mass by Henan Jin Run food additives Co., Ltd with trade name pectin according to concentration
Pectin is dissolved in distilled water, is then adjusted the pH value of resulting solution to 3.8 in mass 82% lactic acid with concentration, obtained
To a kind of pectin solution；
Will be by Xi'an asparagus fern bio tech ltd with trade name Sodium Hyaluronate in mass 5.0% according to concentration
The hyaluronic acid powder of sale is added in distilled water, and fully dissolving is heated under temperature 50 C, a kind of hyaluronic acid solution is made；
C, preparation
Under agitation, 5 parts by weight are extracted in the propolis extract concentration that step A is obtained in mass 32% propolis
Liquid is added to 3.0 parts by weight in the concentration that step B is obtained is 5% collagen liquid in mass, is then sequentially added 0.5 weight
The aloe extract sold by Tianfeng Biological Science ＆ Technology Co., Ltd., Xi'an with trade name aloe extract of amount part and 0.1 parts by weight by
The mint extract that Hunan is sold through continent plant resource explorationses Co., Ltd with trade name mint extract, is well mixed, then
Its mixture is added to the 1.0 parts by weight concentration obtained in step B for 6% pectin solution and 0.1 parts by weight are dense in mass
Spend in the molecular weight 700000Da hyalomitome acid solutions in mass 5.0%, be uniformly mixed, add 10 parts by weight pyrroles
Alkanone carboxylic acid sodium and 0.01 parts by weight phenoxyethanol preservative, 0.0 parts surfactant and 0.3 parts by weight coconut oil bubble
Agent and the distilled water that total amount is 100 parts by weight is supplemented to, mixes, obtain described Feminine care solution.
The Feminine care solution performance that the method described according to this specification is obtained to the present embodiment is determined, its result
It is as follows：
A, performance I antiinflammatory actions
Table 1：Anti-inflammation test result (X ± SD, N=8)
In table：
* significant difference is represented；Similarly hereinafter.
It can be seen that in the result of table 1, Triclosan and Feminine care solution sample manufactured in the present embodiment are equal
With significant antiinflammatory action.
B, performance II itching-relieving actions
Table 2：Antipruritic result of the test (X ± SD)
In table：
* represents that difference is extremely notable；Similarly hereinafter.
Triclosan is generally acknowledged broad spectrum antimicrobial agent, and has good antiphlogistic activity to skin.By the knot of table 2
Fruit is it can be clearly seen that Feminine care solution sample manufactured in the present embodiment has very strong itching-relieving action, and its effect is substantially excellent
In Triclosan.
Embodiment 2：The preparation of Feminine care solution
The implementation steps of the embodiment are as follows：
A, propolis liquid preparation
According to the ratio 1 of propolis in gram and the absolute ethyl alcohol in terms of milliliter：3.8, allow propolis to be carried at room temperature with absolute ethyl alcohol
28min is taken, then isolated extract solution E1With extracting residue R1；
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：4.0, allow and extract residue R1Use concentration
84% ethanol water extracts 25min by volume, then isolated extract solution E2With extracting residue R2；
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：2.2, allow and extract residue R2Use concentration
54% ethanol water extracts 38min by volume, then isolated extract solution E3With extracting residue R3；
By extract solution E1, extract solution E2With extract solution E3Merge；The extract solution of merging is then put in the refrigerator of 4 DEG C of temperature
Put a night paraffin removal, then remove refrigerator, allow the extract solution of paraffin removal to be warming up to room temperature, then pressure 450mmHg, temperature 60 C with
The 20% of original mixture volume is concentrated into carry out rotary evaporation under conditions of 100 revs/min of rotations of rotating speed, a kind of propolis is obtained and carries
Take liquid, the method described using present specification, which is determined, to be determined, in the propolis extract propolis extract concentration be with
Quality meter 30%；
B, preparation raw material solution
Will be by Henan Zheng Xing food additives Co., Ltd with trade name Isin glue collagen in mass 8% according to concentration
The collagen of sale is dissolved in distilled water, and a kind of collagen liquid is made；
It is that 3% will be sold in mass by Henan Jin Run food additives Co., Ltd with trade name pectin according to concentration
Pectin is dissolved in distilled water, is then adjusted the pH value of resulting solution to 4.0 in mass 85% lactic acid with concentration, obtained
To a kind of pectin solution；
Will be by Xi'an asparagus fern bio tech ltd with trade name Sodium Hyaluronate in mass 4.8% according to concentration
The hyaluronic acid powder of sale is added in distilled water, and fully dissolving is heated under temperature 50 C, a kind of hyaluronic acid solution is made；
C, preparation
Under agitation, 7 parts by weight are extracted in the propolis extract concentration that step A is obtained in mass 30% propolis
Liquid is added to 0.5 parts by weight in the concentration that step B is obtained is 8% collagen liquid in mass, is then sequentially added 3.0 weights
The aloe extract sold by Tianfeng Biological Science ＆ Technology Co., Ltd., Xi'an with trade name aloe extract of amount part and 0.2 parts by weight by
The mint extract that Hunan is sold through continent plant resource explorationses Co., Ltd with trade name mint extract, is well mixed, then
Its mixture is added to the 3.0 parts by weight concentration obtained in step B for 3% pectin solution and 0.8 parts by weight are dense in mass
Spend in the molecular weight 400000Da hyalomitome acid solutions in mass 4.8%, be uniformly mixed, add 15 parts by weight pyrroles
Alkanone carboxylic acid sodium and 0.2 parts by weight preservative, 0.2 parts by weight lauroylamidopropyl betaine surfactant and 0.0
Parts by weight foaming agent and the distilled water that total amount is 100 parts by weight is supplemented to, mixes, obtain described Feminine care solution.
The Feminine care solution performance that the method described according to this specification is obtained to the present embodiment is determined, its result
It is as follows：
A, performance I antiinflammatory actions
Table 3：Anti-inflammation test result (X ± SD, N=8)
Triclosan has with Feminine care solution sample manufactured in the present embodiment it can be seen from the result of table 3
Significant antiinflammatory action.
B, performance II itching-relieving actions
Table 4：Antipruritic result of the test (X ± SD)
Triclosan is generally acknowledged broad spectrum antimicrobial agent, and has good antiphlogistic activity to skin.By the knot of table 4
Fruit is it can be clearly seen that Feminine care solution sample manufactured in the present embodiment has very strong itching-relieving action, and its effect is substantially excellent
In Triclosan.
Embodiment 3：The preparation of Feminine care solution
The implementation steps of the embodiment are as follows：
A, propolis liquid preparation
According to the ratio 1 of propolis in gram and the absolute ethyl alcohol in terms of milliliter：4.0, allow propolis to be carried at room temperature with absolute ethyl alcohol
24min is taken, then isolated extract solution E1With extracting residue R1；
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：2.8, allow and extract residue R1Use concentration
88% ethanol water extracts 35min by volume, then isolated extract solution E2With extracting residue R2；
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：1.0, allow and extract residue R2Use concentration
60% ethanol water extracts 30min by volume, then isolated extract solution E3With extracting residue R3；
By extract solution E1, extract solution E2With extract solution E3Merge；The extract solution of merging is then put in the refrigerator of 4 DEG C of temperature
Put a night paraffin removal, then remove refrigerator, allow the extract solution of paraffin removal to be warming up to room temperature, then pressure 550mmHg, 55 DEG C of temperature with
The 25% of original mixture volume is concentrated into carry out rotary evaporation under conditions of 120 revs/min of rotations of rotating speed, a kind of propolis is obtained and carries
Take liquid, the method described using present specification, which is determined, to be determined, in the propolis extract propolis extract concentration be with
Quality meter 40%；
B, preparation raw material solution
Will be by Henan Zheng Xing food additives Co., Ltd with trade name collagen egg in mass 10% according to concentration
The collagen sold in vain is dissolved in distilled water, and a kind of collagen liquid is made；
It is that 8% will be sold in mass by Henan Jin Run food additives Co., Ltd with trade name pectin according to concentration
Pectin is dissolved in distilled water, is then adjusted the pH value of resulting solution to 4.2 in mass 75% lactic acid with concentration, obtained
To a kind of pectin solution；
Will be by Xi'an asparagus fern bio tech ltd with trade name Sodium Hyaluronate in mass 5.2% according to concentration
The hyaluronic acid powder of sale is added in distilled water, and fully dissolving is heated under temperature 50 C, a kind of hyaluronic acid solution is made；
C, preparation
Under agitation, 9 parts by weight are extracted in the propolis extract concentration that step A is obtained in mass 40% propolis
Liquid is added to 1.2 parts by weight in the concentration that step B is obtained is 10% collagen liquid in mass, is then sequentially added 2.2
Aloe extract and 0.5 parts by weight that parts by weight are sold by Tianfeng Biological Science ＆ Technology Co., Ltd., Xi'an with trade name aloe extract
The mint extract sold by Hunan through continent plant resource explorationses Co., Ltd with trade name mint extract, is well mixed, connect
It is 8% pectin solution and 2.0 parts by weight in mass and its mixture is added to the 1.6 parts by weight concentration obtained in step B
Concentration is in 5.2% molecular weight 1000000Da hyalomitome acid solutions in mass, is uniformly mixed, adds 2 parts by weight pyrroles
Pyrrolidone carboxylic acid's sodium and 1.0 parts by weight phenmethylol preservatives, 0.40 parts by weight Cocoamidopropyl betaine surfactant with
0.80 parts by weight amino acid foaming agent and the distilled water that total amount is 100 parts by weight is supplemented to, mixes, obtain described women shield
Manage liquid.
The Feminine care solution performance that the method described according to this specification is obtained to the present embodiment is determined, its result
It is as follows：
A, performance I antiinflammatory actions
Table 5：Anti-inflammation test result (X ± SD, N=8)
Triclosan has with Feminine care solution sample manufactured in the present embodiment it can be seen from the result of table 5
Significant antiinflammatory action.
B, performance II itching-relieving actions
Table 6：Antipruritic result of the test (X ± SD)
Triclosan is generally acknowledged broad spectrum antimicrobial agent, and has good antiphlogistic activity to skin.By the knot of table 6
Fruit is it can be clearly seen that Feminine care solution sample manufactured in the present embodiment has very strong itching-relieving action, and its effect is substantially excellent
In Triclosan.
Embodiment 4：The preparation of Feminine care solution
The implementation steps of the embodiment are as follows：
A, propolis liquid preparation
According to the ratio 1 of propolis in gram and the absolute ethyl alcohol in terms of milliliter：5.0, allow propolis to be carried at room temperature with absolute ethyl alcohol
20min is taken, then isolated extract solution E1With extracting residue R1；
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：3.2, allow and extract residue R1Use concentration
80% ethanol water extracts 32min by volume, then isolated extract solution E2With extracting residue R2；
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：3.0, allow and extract residue R2Use concentration
58% ethanol water extracts 34min by volume, then isolated extract solution E3With extracting residue R3；
By extract solution E1, extract solution E2With extract solution E3Merge；The extract solution of merging is then put in the refrigerator of 4 DEG C of temperature
Put a night paraffin removal, then remove refrigerator, allow the extract solution of paraffin removal to be warming up to room temperature, then pressure 480mmHg, temperature 50 C with
The 28% of original mixture volume is concentrated into carry out rotary evaporation under conditions of 110 revs/min of rotations of rotating speed, a kind of propolis is obtained and carries
Take liquid, the method described using present specification, which is determined, to be determined, in the propolis extract propolis extract concentration be with
Quality meter 36%；
B, preparation raw material solution
Will be by Henan Zheng Xing food additives Co., Ltd with trade name Isin glue collagen in mass 8% according to concentration
The collagen of sale is dissolved in distilled water, and a kind of collagen liquid is made；
It is that 4% will be sold in mass by Henan Jin Run food additives Co., Ltd with trade name pectin according to concentration
Pectin is dissolved in distilled water, is then adjusted the pH value of resulting solution to 4.0 in mass 78% lactic acid with concentration, obtained
To a kind of pectin solution；
Will be by Xi'an asparagus fern bio tech ltd with trade name Sodium Hyaluronate in mass 5.0% according to concentration
The hyaluronic acid powder of sale is added in distilled water, and fully dissolving is heated under temperature 50 C, a kind of hyaluronic acid solution is made；
C, preparation
Under agitation, 10 parts by weight are carried in the propolis extract concentration that step A is obtained in mass 36% propolis
Take liquid to be added to 2.2 parts by weight in the concentration that step B is obtained is 8% collagen liquid in mass, be then sequentially added 1.2
Aloe extract and 0.4 parts by weight that parts by weight are sold by Tianfeng Biological Science ＆ Technology Co., Ltd., Xi'an with trade name aloe extract
The mint extract sold by Hunan through continent plant resource explorationses Co., Ltd with trade name mint extract, is well mixed, connect
It is 4% pectin solution and 1.4 parts by weight in mass and its mixture is added to the 3.3 parts by weight concentration obtained in step B
Concentration is in 5.0% molecular weight 500000Da hyalomitome acid solutions in mass, is uniformly mixed, adds 6 parts by weight pyrroles
Pyrrolidone carboxylic acid's sodium and 0.6 parts by weight anesin preservative, 0.1 parts by weight of polyoxyethylene Arlacel-40
Surfactant and 0.6 parts by weight coconut oil foaming agent and be supplemented to total amount be 100 parts by weight distilled water, mix, obtain
Described Feminine care solution.
The Feminine care solution performance that the method described according to this specification is obtained to the present embodiment is determined, its result
It is as follows：
A, performance I antiinflammatory actions
Table 7：Anti-inflammation test result (X ± SD, N=8)
Triclosan and Feminine care solution sample manufactured in the present embodiment are equal it can be seen from the result of table 7
There is significant antiinflammatory action.
B, performance II itching-relieving actions
Table 8：Antipruritic result of the test (X ± SD)
Triclosan is generally acknowledged broad spectrum antimicrobial agent, and has good antiphlogistic activity to skin.By the knot of table 8
Fruit is it can be clearly seen that Feminine care solution sample manufactured in the present embodiment has very strong itching-relieving action, and its effect is substantially better than
Triclosan.
Claims (9)
1. a kind of preparation method of Feminine care solution, it is characterised in that as follows the step of this method：
A, propolis liquid preparation
According to the ratio 1 of propolis in gram and the absolute ethyl alcohol in terms of milliliter：3~5, allow propolis to use absolute ethyl alcohol ultrasonic wave at room temperature
20~30min is extracted, then isolated extract solution E1With extracting residue R1；
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：2~4, allow and extract residue R1With concentration with body
Product counts 80~90% ethanol water 25~35min of ultrasonic wave extraction, then isolated extract solution E2With extracting residue R2；
Then, according to the ratio 1 of propolis in gram and the ethanol water in terms of milliliter：1~3, allow and extract residue R2With concentration with body
Product counts 50~60% ethanol water 30~40min of ultrasonic wave extraction, then isolated extract solution E3With extracting residue R3；
By extract solution E1, extract solution E2With extract solution E3Merge；The extract solution of merging then places one in the refrigerator of 4 DEG C of temperature
Night paraffin removal, then removes refrigerator, allows the extract solution of paraffin removal to be warming up to room temperature, then carries out rotary evaporation concentration, obtains propolis and carry
Take the propolis extract that thing concentration is in mass 30~40%；
B, preparation raw material solution
Collagen is dissolved in distilled water in mass 5~10% according to concentration, a kind of collagen liquid is made；
Pectin is dissolved in distilled water in mass 3~8% according to concentration, then the pH value of resulting solution is adjusted with lactic acid
Section obtains a kind of pectin solution to 3.8~4.2；
According to concentration 4.8~5.2% hyaluronic acid powder to be added in mass in distilled water, heated under temperature 50 C abundant
Dissolving, is made a kind of hyaluronic acid solution；
C, preparation
Under agitation, 5~10 parts by weight 0.5~3.0 parts by weight are added in the obtained propolis extracts of step A to obtain in step B
To collagen liquid in, be then sequentially added 0.5~3.0 parts by weight aloe extract and 0.1~0.5 parts by weight peppermint and extract
Thing, is well mixed, then its mixture is added in 1~3 obtained parts by weight pectin solutions of step B and 0.1~2.0 parts by weight
In hyalomitome acid solution, it is uniformly mixed, adds 2~15 parts by weight pyrrolidone sodium carboxylates and 0.01~1.0 parts by weight are anti-
Rotten agent and the distilled water that total amount is 100 parts by weight is supplemented to, mixes, obtain described Feminine care solution.
2. preparation method according to claim 1, it is characterised in that in step, described rotary evaporation concentration be
Carried out under the conditions of 45~60 DEG C of temperature.
3. preparation method according to claim 1, it is characterised in that in stepb, the concentration of the lactic acid is with quality
Meter 75~85%.
4. preparation method according to claim 1, it is characterised in that in stepb, the molecular weight of the hyaluronic acid is
400000~2,000,000 Da.
5. preparation method according to claim 1, it is characterised in that in step C, described preservative is selected from benzene oxygen second
Alcohol, sodium benzoate, phenmethylol or anesin.
6. preparation method according to claim 1, it is characterised in that in step C, add pyrrolidone sodium carboxylate and
Added again after preservative in terms of Feminine care solution gross mass 0.01~0.1% amphoteric surfactant or non-ionic surface active
Agent.
7. preparation method according to claim 6, it is characterised in that described amphoteric surfactant is selected from lauramide
CAB, Cocoamidopropyl betaine, dodecyl alanine, lauryl both sexes sodium acetate, coconut oil monoethanol
Acid amides or lecithin；Described nonionic surfactant is selected from polyoxyethylene sorbitan monolaurate, polyoxyethylene
Arlacel-40, polyethenoxy sorbitan monostearate or polyethylene glycol.
8. preparation method according to claim 1, it is characterised in that in step C, add pyrrolidone sodium carboxylate and
Added again after preservative in terms of Feminine care solution gross mass 0.1~0.4% foaming agent.
9. preparation method according to claim 8, it is characterised in that described foaming agent is coconut oil foaming agent or amino
Sour foaming agent.
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| CN107184955A (en) * | 2017-06-05 | 2017-09-22 | 深圳肽护科技有限公司 | A kind of Ms's care composition containing polypeptide and preparation method thereof |
| CN111686064A (en) * | 2020-07-09 | 2020-09-22 | 广州欧正化妆品技术研究院有限公司 | Mineral-combined gynecological antibacterial nursing lotion and preparation method thereof |
| CN115737705A (en) * | 2022-11-17 | 2023-03-07 | 杭州瑞宇医疗用品有限公司 | Lotion for cleaning female private parts and preparation method thereof |
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