CN106139169A - A kind of bactericidal medical ultrasonic couplant and preparation method thereof - Google Patents
A kind of bactericidal medical ultrasonic couplant and preparation method thereof Download PDFInfo
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- CN106139169A CN106139169A CN201510158348.8A CN201510158348A CN106139169A CN 106139169 A CN106139169 A CN 106139169A CN 201510158348 A CN201510158348 A CN 201510158348A CN 106139169 A CN106139169 A CN 106139169A
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- kazon
- acritamer
- medical ultrasonic
- bactericidal
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Abstract
The present invention relates to a kind of bactericidal medical ultrasonic couplant and preparation method thereof, according to mass percent, including: Acritamer 940: 0.3-1%；Glycerol: 3-10%；Propylene glycol: 3-7%；Triethanolamine: 0.3-1%；Triclosan: 0.02-0.07%；Kazon: 0.02-0.07%；Deionized water: 80-90%, the present invention is by adding a certain proportion of Kazon as antiseptic and inhibiting bacteria function agent, the order of material mixing the temperature of strict control of material and mixing speed is adjusted during configuration, solve this product the most easily to lump and the many technical barrier of bubble, there is good biocompatibility and to skin no cytotoxicity, without sensitization, non-stimulated, there is good bactericidal and bacteriostatic effect, human body is avoided to produce cross infection, safely and effectively, free from extraneous odour, easy-clear.
Description
Technical field
The present invention relates to a kind of couplant, particularly relate to a kind of bactericidal medical ultrasonic couplant and
Its preparation method.
Background technology
Ultrasonic diagnosis with therapeutic process need use a kind of filling or be coated on probe radiation
Between face and human epidermal, mucosa, in order to the ultrasonic neutral medium of transmitted acoustic pulse, the most medical super
Acoustic couplant, medical ultrasonic coupling agent, in clinical practice, is formed and makes ultrasound wave smooth and easy and do not lose
Handing down in a direct line from the master the passage broadcast, play a part entrant sound medium, in Clinical practice, people are not concerned only with
The most whether its acoustic characteristic, also pays close attention to its safety and effectiveness, can be to human body
Produce cross infection, the most also occur in that a lot of sterilization, sterilization class medical supersonic coupling
Agent, i.e. adds a certain proportion of antibacterial on the basis of original, but much with the addition of sterilization
Easily there is caking, the problems such as bubble is many in the couplant of agent, affects quality and the use of couplant
Effect.
Summary of the invention
For the present situation of above-mentioned prior art, the technical problem to be solved is to provide
One has bactericidal and bacteriostatic effect, and intermiscibility is good, can solve killing of problems such as luming, bubble is many
Bacterial type medical ultrasonic coupling agent and preparation method thereof.
The present invention solves the technical scheme that above-mentioned technical problem used: a kind of bactericidal medical
Ultrasonic coupling agent, according to mass percent, including:
Acritamer 940: 0.3-1%；
Glycerol: 3-10%；
Propylene glycol: 3-7%；
Triethanolamine: 0.3-1%；
Triclosan: 0.02-0.07%；
Kazon: 0.02-0.07%；
Deionized water: 80-90%.
The preparation method of a kind of bactericidal medical ultrasonic couplant, comprises the steps:
A, joining in deionized water by Acritamer 940, temperature controls between 30-40 degree,
Stirring makes Acritamer 940 swelling；
B, triclosan is dissolved in propylene glycol, and adds in the solution of step (a)；
C, by glycerol, Kazon add step (a) solution in continue stirring, make various raw material
Dissolve；
D, on the basis of step (c), it is slow added into triethanolamine, the PH of regulation solution
Between value is for 6.5-7.5；
E, vacuum stand 30 minutes, and then vacuum is slowly stirred 60 minutes, and mixing speed is
30-40 per minute turns；
F, obtain transparent bubble-free gel；
G, fill.
Compared with prior art, it is an advantage of the current invention that: the present invention is by adding certain proportion
Kazon as antiseptic and inhibiting bacteria function agent, during configuration, adjust the order of material mixing and strictly control
The temperature of prepared material and mixing speed, solve this product and the most easily lump and bubble
Many technical barriers, have good biocompatibility and to skin no cytotoxicity, without sensitization,
Non-stimulated, there is good bactericidal and bacteriostatic effect, it is to avoid human body produces cross infection, safety has
Effect, free from extraneous odour, easy-clear.
Detailed description of the invention
Below by embodiment, the present invention is described in further detail, and following example are right
The explanation of the present invention and the invention is not limited in following example.
A kind of bactericidal medical ultrasonic couplant, according to mass percent, including:
Acritamer 940: 0.3-1%；
Glycerol: 3-10%；
Propylene glycol: 3-7%；
Triethanolamine: 0.3-1%；
Triclosan: 0.02-0.07%；
Kazon: 0.02-0.07%；
Deionized water: 80-90%.
Wherein, Acritamer 940, as gel-type vehicle, has the important use such as thickening suspension, card ripple
Nurse 940 is acrylic acid bonding allyl sucrose or the high molecular polymer of tetramethylolmethane allyl ether,
Good stability, it is adaptable in emulsion, gel；Glycerol as wetting agent, no color or smell, can be from
Absorbing moisture in air, price is low, and moistening effect is good；Propylene glycol is as solvent, viscosity and suction
Moist good；Triethanolamine as nertralizer, by neutralizing with the carboxyl such as carbomer, is formed stable
Macromolecular structure, reach the application effect of thickening and moisturizing；Triclosan as sterilization bacteriostat,
Can effectively suppress noxious bacteria, highly effective and safe, be the active component of medical treatment sterile products；Kazon
As antiseptic and inhibiting bacteria function agent, toxicity is low, and antibacterial action scope is wide, and effect is strong, with various emulsifying agents,
Surfactant intermiscibility is good, has the compatibility of excellence.
The preparation method of a kind of bactericidal medical ultrasonic couplant, comprises the steps:
A, joining in deionized water by Acritamer 940, temperature controls between 30-40 degree,
Stirring makes Acritamer 940 swelling；
B, triclosan is dissolved in propylene glycol, and adds in the solution of step (a)；
C, by glycerol, Kazon add step (a) solution in continue stirring, make various raw material
Dissolve；
D, on the basis of step (c), it is slow added into triethanolamine, the PH of regulation solution
Between value is for 6.5-7.5；
E, vacuum stand 30 minutes, and then vacuum is slowly stirred 60 minutes, and mixing speed is
30-40 per minute turns；
F, obtain transparent bubble-free gel；
G, fill.
This product at room temperature preserves 30-40 days, has no the problems such as precipitation, caking, bubble are many,
Also formed without bacterial plaque, it can be seen that, this product has good stability and bacteriostasis.
The present invention is by adding a certain proportion of Kazon as antiseptic and inhibiting bacteria function agent, during configuration
Adjust the order of material mixing the temperature of strict control of material and mixing speed, solve this product
The technical barrier that product the most easily lump and bubble is many, has good biocompatibility
With to skin no cytotoxicity, without sensitization, non-stimulated, there is good bactericidal and bacteriostatic effect,
Human body is avoided to produce cross infection, safely and effectively, free from extraneous odour, easy-clear.
Last it is noted that above example is only in order to illustrate technical scheme, and
Non-to its restriction；Although the present invention being described in detail with reference to previous embodiment, ability
Territory it will be appreciated by the skilled person that it still can be to the technical side described in foregoing embodiments
Case is modified, or replaces wherein portion of techniques feature on an equal basis；And these amendment or
Person replaces, and does not make the essence of appropriate technical solution depart from various embodiments of the present invention technical scheme
Spirit and scope.
Claims (2)
1. a bactericidal medical ultrasonic couplant, it is characterised in that according to mass percent,
Including:
Acritamer 940: 0.3-1%；
Glycerol: 3-10%；
Propylene glycol: 3-7%；
Triethanolamine: 0.3-1%；
Triclosan: 0.02-0.07%；
Kazon: 0.02-0.07%；
Deionized water: 80-90%.
2. the preparation method of a bactericidal medical ultrasonic couplant, it is characterised in that include as
Lower step:
A, joining in deionized water by Acritamer 940, temperature controls between 30-40 degree,
Stirring makes Acritamer 940 swelling；
B, triclosan is dissolved in propylene glycol, and adds in the solution of step (a)；
C, by glycerol, Kazon add step (a) solution in continue stirring, make various raw material
Dissolve；
D, on the basis of step (c), it is slow added into triethanolamine, the PH of regulation solution
Between value is for 6.5-7.5；
E, vacuum stand 30 minutes, and then vacuum is slowly stirred 60 minutes, and mixing speed is
30-40 per minute turns；
F, obtain transparent bubble-free gel；
G, fill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510158348.8A CN106139169A (en) | 2015-04-02 | 2015-04-02 | A kind of bactericidal medical ultrasonic couplant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510158348.8A CN106139169A (en) | 2015-04-02 | 2015-04-02 | A kind of bactericidal medical ultrasonic couplant and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106139169A true CN106139169A (en) | 2016-11-23 |
Family
ID=57338757
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510158348.8A Pending CN106139169A (en) | 2015-04-02 | 2015-04-02 | A kind of bactericidal medical ultrasonic couplant and preparation method thereof |
Country Status (1)
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107184911A (en) * | 2017-06-19 | 2017-09-22 | 太原谷歌医药科技有限公司 | One kind is used to prevent cervical carcinoma and treatment papillomavirus（HPV）Infection and the product and preparation method of colpitis |
| CN107670056A (en) * | 2017-10-10 | 2018-02-09 | 郑州康宜健医疗器械有限责任公司 | A kind of antibacterial coupled patch of medical supersonic and preparation method thereof |
| CN108853522A (en) * | 2018-08-22 | 2018-11-23 | 济南秦鲁药业科技有限公司 | Medical disinfection couplant and preparation method thereof |
| CN109289059A (en) * | 2018-11-28 | 2019-02-01 | 广州润虹医药科技股份有限公司 | A kind of bactericidal medical ultrasonic couplant and preparation method thereof |
| CN110327445A (en) * | 2019-08-12 | 2019-10-15 | 贵州苗仁堂制药有限责任公司 | A kind of anti-HPV viruse, anti-cervix neoplasms seedling medicine compound preparation |
-
2015
- 2015-04-02 CN CN201510158348.8A patent/CN106139169A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107184911A (en) * | 2017-06-19 | 2017-09-22 | 太原谷歌医药科技有限公司 | One kind is used to prevent cervical carcinoma and treatment papillomavirus（HPV）Infection and the product and preparation method of colpitis |
| CN107670056A (en) * | 2017-10-10 | 2018-02-09 | 郑州康宜健医疗器械有限责任公司 | A kind of antibacterial coupled patch of medical supersonic and preparation method thereof |
| CN107670056B (en) * | 2017-10-10 | 2020-07-10 | 郑州康宜健医疗器械有限责任公司 | Medical ultrasonic antibacterial coupling patch and preparation method thereof |
| CN108853522A (en) * | 2018-08-22 | 2018-11-23 | 济南秦鲁药业科技有限公司 | Medical disinfection couplant and preparation method thereof |
| CN109289059A (en) * | 2018-11-28 | 2019-02-01 | 广州润虹医药科技股份有限公司 | A kind of bactericidal medical ultrasonic couplant and preparation method thereof |
| CN110327445A (en) * | 2019-08-12 | 2019-10-15 | 贵州苗仁堂制药有限责任公司 | A kind of anti-HPV viruse, anti-cervix neoplasms seedling medicine compound preparation |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161123 |