JP3253982B2 - Acne cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a cosmetic for acne .

[0002]

2. Description of the Related Art Conventionally, salicylic acid or resorcin has been incorporated into cosmetics as an active ingredient having a disinfecting and exfoliating action as a therapeutic agent for acne. In addition, as pharmaceuticals, there are those in which steroids and the like are added to the external preparation for skin in addition to salicylic acid.

[0003]

However, the above-mentioned salicylic acid and resorcinol have problems in safety, such as irritation to the skin, and steroid preparations have a problem in side effects.

[0004] The present invention has been made in view of the above points, and it is an object of the present invention to provide a remedy for acne which has little effect on the human body and is extremely safe.

[0005]

Means for Solving the Problems In order to solve such problems, the present inventors have conducted intensive studies on highly safe natural organic compounds. As a result, chitin, chitosan or its oligosaccharides and partial degradation The present inventors have found that a product or the like has an excellent antibacterial action against acne bacteria, and have completed the present invention. That is, a means for solving the above-mentioned problem is Propionibacterium acnes (Propionibact
In other words , a chitin oligosaccharide having an antibacterial action against erium acnes) , chitin or a partially decomposed product thereof, or a chitosan oligosaccharide, chitosan or a partially decomposed product thereof is incorporated into a cosmetic as an active ingredient.

[0006]

Embodiments of the present invention will be described below. Example 1 The therapeutic agent for acne of this example is composed of chitin oligosaccharide. The chitin oligosaccharide used in this example was produced by N-acetylation of chitosan oligosaccharide. The more specific composition of the chitin oligosaccharide used in this example is shown in Table 1 below.
It is as follows.

[Table 1]

Next, the composition of the chitin oligosaccharide formulated in a vanishing cream as an example of a cosmetic as a medicinal component for acne treatment is shown in Table 2 below.

[Table 2]

Example 2 The therapeutic agent for acne of this example is composed of chitosan oligosaccharide. The more specific composition of the chitosan oligosaccharide used in this example is as shown in Table 3 below.

[Table 3] In addition, this chitosan oligosaccharide is used as a medicinal component for acne treatment in a cosmetic as in Example 1 above.

Test Example Next, the chitin oligosaccharide of Example 1 and the chitosan oligosaccharide of Example 2 were used for propioni , an acne bacterium.
Bacterium acnes (Propionibacteriumacnes)
MIC (minimum growth inhibitory concentration) was measured.

(1) Medium The above-mentioned Propionibacterium acne was used as a test strain.
(Propionibacterium acnes), and the medium for the test strain used was the one shown in Table 4 below.

[Table 4] The medium was adjusted to pH 7.0, and contained the components shown in Table 4 to make a total volume of 1,000 ml with water.

(2) Measurement method The above medium was prepared, dispensed into a 16 mmφ test tube, and autoclaved. Chitin oligosaccharide, chitosan oligosaccharide,
A 10% aqueous solution was prepared. In particular, chitosan oligosaccharide was adjusted to pH around 6, then sterilized by filtration, and added to each autoclaved liquid medium to make 10 ml. Then, 0.05 ml of a culture solution which had been seed-cultured in advance was inoculated thereto, and was inoculated at an appropriate temperature (for bacteria 37).
C. and a fungus at 25.degree. C.) to determine the MIC. MI
C was determined 96 hours later by adding the indicator BTB and determining the presence or absence of bacterial growth by a change in pH (change in color).

(3) Measurement Results The MIC value was 0.1% for chitin oligosaccharide and 0.005% for chitosan oligosaccharide. As is clear from these results, both the chitin oligosaccharide of Example 1 and the chitosan oligosaccharide of Example 2 were propionibacteria.
Antibacterial activity against acnes (Propionibacterium acnes) was observed.

[0013] Other embodiments In the above embodiment, chitin oligosaccharides, but acne therapeutic agent only with chitosan oligosaccharide was configured, the other ingredients as a base, are formulated in the base A therapeutic agent for acne may be constituted. The point is that chitin oligosaccharide and chitosan oligosaccharide only need to be contained as active ingredients. In the present invention, the term "contained as an active ingredient" refers to a case where the therapeutic agent for acne is composed of chitin oligosaccharide or chitosan oligosaccharide alone, as described in the above Examples, in addition to the case where it is incorporated in another base. This is a broad concept including the case where it is configured.

In this embodiment, chitin oligosaccharide or chitosan oligosaccharide was used as an active ingredient of a therapeutic agent for acne. Instead of these oligosaccharides, high molecular weight chitin, chitosan, or a partially decomposed product thereof was used as an active ingredient. It is also possible. The point is that chitin oligosaccharide, chitin or a partial degradation product thereof, or chitosan oligosaccharide, chitosan or a partial degradation product thereof may be contained as an active ingredient of a therapeutic agent for acne. However, compared to high molecular weight chitin and chitosan, the oligosaccharides as in the above examples are soluble in water, and are widely used as a therapeutic agent for acne, as they can be easily incorporated into other bases. There is an advantage that you can.

Further, in the above embodiment, the case where the therapeutic agent for acne is blended into a vanishing cream as an example of a cosmetic is described. However, the use of the therapeutic agent for acne is not limited to this. It is also possible to use .

[0016]

As described above, the present invention contains chitin oligosaccharide or chitosan oligosaccharide, which is a natural polysaccharide, or chitin, chitosan or a partially decomposed product thereof as an active ingredient. Unlike salicylic acid, resorcinol, steroids and the like, which are blended in cosmetics and pharmaceuticals, there is no effect on the human body and there is an effect that the safety is high. It also has an excellent antibacterial effect on acne bacteria.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ identification code FI C08B 37/08 C08B 37/08 A (58) Field surveyed (Int.Cl. ⁷ , DB name) A61K 7/00-7 / 50 C07H 5/04-5/06 C08B 37/08 A61K 31/7016-31/702 722 BIOSIS (DIALOG) CA (STN) MEDLINE (STN) WPI (DIALOG)

Claims (1)

(57) [Claims] (1) Propionibacterium acnes ( Pr
1. A cosmetic composition for acne, comprising chitin oligosaccharide, chitin or a partially degraded product thereof, or chitosan oligosaccharide, chitosan or a partially degraded product thereof, having an antibacterial action against opionibacterium acnes ) as an active ingredient.