CN106075483A - A kind of ultrasonic coupling agent for medical ultrasonic diagnosis and treatment and preparation method thereof - Google Patents
A kind of ultrasonic coupling agent for medical ultrasonic diagnosis and treatment and preparation method thereof Download PDFInfo
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- CN106075483A CN106075483A CN201610681855.4A CN201610681855A CN106075483A CN 106075483 A CN106075483 A CN 106075483A CN 201610681855 A CN201610681855 A CN 201610681855A CN 106075483 A CN106075483 A CN 106075483A
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- ammonium salt
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- 239000007822 coupling agent Substances 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 238000011282 treatment Methods 0.000 title claims abstract description 20
- 238000003745 diagnosis Methods 0.000 title claims abstract description 18
- -1 morpholine quaternary ammonium salt Chemical class 0.000 claims abstract description 40
- 229920002101 Chitin Polymers 0.000 claims abstract description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Natural products C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 24
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 7
- 239000012141 concentrate Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 239000000376 reactant Substances 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 238000004364 calculation method Methods 0.000 claims description 2
- 239000000178 monomer Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 12
- 238000013016 damping Methods 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 239000000523 sample Substances 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 230000008733 trauma Effects 0.000 description 4
- 238000005160 1H NMR spectroscopy Methods 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 206010011409 Cross infection Diseases 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- 206010029803 Nosocomial infection Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000035617 depilation Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000000642 iatrogenic effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000005311 nuclear magnetism Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of ultrasonic coupling agent for medical ultrasonic diagnosis and treatment and preparation method thereof, wherein, this ultrasonic coupling agent consists of the following composition: chitin morpholine quaternary ammonium salt, Polyethylene Glycol, glycerol, triethanolamine and the water of surplus；Described chitin morpholine quaternary ammonium salt is that chitin reacts, with methylglycidyl morpholine quaternary ammonium salt, the product obtained.The ultrasonic coupling agent for medical ultrasonic diagnosis and treatment that the present invention provides has strong bactericidal action and minimum acoustical damping properties.
Description
Technical field
The present invention relates to a kind of ultrasonic coupling agent for medical ultrasonic diagnosis and treatment and preparation method thereof.
Background technology
At present, medical ultrasonic diagnosis and treatment commonly use ultrasonic coupling agent as medium, be used for strengthening ultrasonic probe and human body
The air between coupling and isolation ultrasonic probe and examined area skin between skin, makes to reduce in sound wave conductive process
Decay, checks result accurately to obtain.Therefore, the definition of ultrasonic medical image and resolving power, except relevant to equipment, also
Closely related with the quality of ultrasonic coupling agent, particularly relevant to the acoustic attenuation coefficient of ultrasonic coupling agent.
In ultrasonic medical, owing to ultrasonic probe contacts with person under inspection's body skin or tract mucosa, continuous ultrasound is examined
During treatment, ultrasonic probe frequently contacts different patient, there is the potential danger of medical cross infection.In order to overcome antibacterial to infect, existing
Some methods are by addition antibacterial is made antibacterial type ultrasonic coupling agent, and on the one hand the addition of antibacterial can affect ultrasonic
The stability of couplant, on the other hand also can increase acoustic attenuation coefficient so that ultrasonic medical Quality Down.Such as
Ultrasonic coupling agent acoustic attenuation disclosed in CN102107013B, CN103432600B has all reached more than 0.2dB/ (cm MHz),
Far beyond the standard of acoustic attenuation≤0.05dB/ in YY 0299-2008 (cm MHz), product is defective.
In view of the excellent treatment effect of medical ultrasound equipment and its be widely applied, this area needs exploitation one tool badly
There is the ultrasonic coupling agent of extremely low acoustic attenuation coefficient.
Summary of the invention
It is an object of the invention to the defect overcoming existing antibacterial type ultrasonic coupling agent acoustic attenuation coefficient excessive, it is provided that one
Kind for ultrasonic coupling agents and preparation method thereof of medical ultrasonic diagnosis and treatment, this ultrasonic coupling agent has extremely low acoustic attenuation coefficient and relatively
The performance of strong sterilization.
The present inventor has been surprisingly found that under study for action, chitin and methylglycidyl morpholine quaternary ammonium salt is reacted
To chitin morpholine quaternary ammonium salt, to be then prepared as gel with the water of Polyethylene Glycol, glycerol, triethanolamine and surplus ultrasonic
Couplant, has minimum acoustic attenuation coefficient and good bactericidal property.
To achieve these goals, on the one hand, the present invention provides a kind of medical ultrasonic coupling agent, wherein, this medical supersonic
Couplant consists of the following composition:
Chitin morpholine quaternary ammonium salt, Polyethylene Glycol, glycerol, triethanolamine and the water of surplus；Described chitin morpholine
Quaternary ammonium salt is that chitin reacts, with methylglycidyl morpholine quaternary ammonium salt, the product obtained.
Preferably, this medical ultrasonic coupling agent weight percentage composition is: chitin morpholine quaternary ammonium salt 2～6%, poly-second two
Alcohol 1～5%, glycerol 3～6%, triethanolamine 0.1～0.5% and the water of surplus.
Preferably, the preparation method of described chitin morpholine quaternary ammonium salt is: under nitrogen protection, by chitin, methyl ring
Oxygen propylmorpholin quaternary ammonium salt, sodium hydroxide join in DMSO 35～45 DEG C and react 8～12 hours, are cooled to room temperature, and hydrochloric acid is adjusted
Joint pH to 6～7, reactant liquor concentrates, and recrystallizing methanol obtains chitin morpholine quaternary ammonium salt.Described methylglycidyl morpholine quaternary ammonium
Salt can be such as methylglycidyl morpholine ammonium chloride.
Preferably, chitin, methylglycidyl morpholine quaternary ammonium salt, sodium hydroxide concentration mol ratio be 1:1.5～2:2～
3, wherein chitin is with the amount of monomer molecule amount substance for calculation.It is further preferred that chitin, methylglycidyl morpholine quaternary ammonium
Salt, sodium hydroxide concentration mol ratio are 1:2:3.
On the other hand, the present invention also provides for the preparation method of a kind of above-mentioned medical ultrasonic coupling agent, this preparation method bag
Include:
1) will chitin morpholine quaternary ammonium salt, Polyethylene Glycol, glycerol, triethanolamine and water addition reactor mix
Close, be heated to 65 DEG C, be incubated 10 minutes, filter；
2) by step 1) filtrate that is filtrated to get carries out supersound process 5～10min, obtains medical ultrasonic coupling agent.
The ultrasonic coupling agent of the present invention is colorless transparent gel shape product, and properties all meets wanting of YY 0299-2008
Ask.
Compared with prior art, the ultrasonic coupling agent advantage of the present invention shows: the ultrasonic coupling agent of the present invention need not
Additionally add antibacterial, it is to avoid the existing antibacterial impact on ultrasonic coupling agent stability etc.；The ultrasonic coupling agent of the present invention
Site of action is not stimulated；The ultrasonic coupling agent range of application of the present invention is wider, may be used for having the skin of wound, have wound
Mucosa etc., and there is the effect promoting wound healing simultaneously；The ultrasonic coupling agent attenuation quotient of the present invention is little, at probe and skin
Form good infiltration, not mummification after coating between skin, it is possible to keep viscosity, pop one's head in along the detection smooth and easy sliding in position, and in water
Dissolubility, easy cleaning.The ultrasonic coupling agent preparation technology of the present invention is simple, is particularly suitable for large-scale production.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is expanded on further.But these embodiments be only limitted to illustrate the present invention and not
It it is the further restriction to protection scope of the present invention.In the present invention, nuclear-magnetism is entered by Brooker AVANCE III 400MHz
Row test, TMS internal standard.
Preparation example 1
The preparation method of described chitin morpholine quaternary ammonium salt is: under nitrogen protection, by 100g chitin, 135.6g methyl
Glycidyl morpholine quaternary ammonium salt, 51.4g sodium hydroxide join in DMSO 35 DEG C and react 12 hours, are cooled to room temperature, and hydrochloric acid is adjusted
Joint pH to 6～7, reactant liquor concentrates, and recrystallizing methanol obtains chitin morpholine quaternary ammonium salt.1HNMR (DMSO, d6) 1.95 (s,
3H), 3.18 (s, 3H), 3.31 (s, 3H), 3.45 (m, 4H), 3.51～3.60 (m, 11H), 4.37～4.53 (m, 5H), 4.75
(s, br, 1H), 5.22 (s, br, 1H), 7.92 (s, 1H).
Preparation example 2
The preparation method of described chitin morpholine quaternary ammonium salt is: under nitrogen protection, by 100g chitin, 101.7g methyl
Glycidyl morpholine quaternary ammonium salt, 34.3g sodium hydroxide join in DMSO 45 DEG C and react 12 hours, are cooled to room temperature, and hydrochloric acid is adjusted
Joint pH to 6～7, reactant liquor concentrates, and recrystallizing methanol obtains chitin morpholine quaternary ammonium salt.1HNMR (DMSO, d6) 1.95 (s,
3H), 3.19 (s, 3H), 3.31 (s, 3H), 3.45 (m, 4H), 3.53～3.60 (m, 11H), 4.37～4.53 (m, 5H), 4.78
(s, br, 1H), 5.23 (s, br, 1H), 7.92 (s, 1H).
Preparation example 3
The preparation method of described chitin morpholine quaternary ammonium salt is: under nitrogen protection, by 100g chitin, 99.6g front three
Basic ring oxygen quaternary ammonium salts, 68.6g sodium hydroxide join in DMSO 35 DEG C and react 12 hours, are cooled to room temperature, and hydrochloric acid regulates
PH to 6～7, reactant liquor concentrates, and recrystallizing methanol obtains chitin morpholine quaternary ammonium salt.1HNMR (DMSO, d6) 1.95 (s, 3H),
3.20 (s, 7H), 3.31 (s, 3H), 3.51～3.60 (m, 6H), 4.37～4.53 (m, 4H), 4.75 (s, br, 1H), 5.22 (s,
Br, 1H), 7.92 (s, 1H).
Embodiment 1
For the ultrasonic coupling agent A1 of medical ultrasonic diagnosis and treatment, preparation method is as follows:
1) by 4g chitin morpholine quaternary ammonium salt (preparation example 1), 5g Polyethylene Glycol, 3g glycerol, 0.2g triethanolamine and
87.8g water adds in reactor and mixes, and is heated to 65 DEG C, is incubated 10 minutes, filters；
2) by step 1) filtrate that is filtrated to get carries out supersound process 5～10min, obtains colorless transparent gel shape medical super
Acoustic couplant.
Embodiment 2
For the ultrasonic coupling agent A2 of medical ultrasonic diagnosis and treatment, preparation method is as follows:
1) by 2g chitin morpholine quaternary ammonium salt (preparation example 1), 5g Polyethylene Glycol, 6g glycerol, 0.1g triethanolamine and
86.9g water adds in reactor and mixes, and is heated to 65 DEG C, is incubated 10 minutes, filters；
2) by step 1) filtrate that is filtrated to get carries out supersound process 5～10min, obtains colorless transparent gel shape medical super
Acoustic couplant.
Embodiment 3
For the ultrasonic coupling agent A3 of medical ultrasonic diagnosis and treatment, preparation method is as follows:
1) by 6g chitin morpholine quaternary ammonium salt (preparation example 2), 1g Polyethylene Glycol, 4g glycerol, 0.5g triethanolamine and
88.5g water adds in reactor and mixes, and is heated to 65 DEG C, is incubated 10 minutes, filters；
2) by step 1) filtrate that is filtrated to get carries out supersound process 5～10min, obtains colorless transparent gel shape medical super
Acoustic couplant.
Embodiment 4
For the ultrasonic coupling agent A4 of medical ultrasonic diagnosis and treatment, such as the preparation method in embodiment 1, except that, carapace
Element morpholine quaternary ammonium salt is to prepare in preparation example 3.
Comparative example 1
The preparation method of ultrasonic coupling agent as described in Example 1, except that, in preparation method, use identical
The chitin of weight substitutes chitin morpholine quaternary ammonium salt, obtains ultrasonic coupling agent DA1.
Test case
One, ultrasonic coupling agent performance test
Ultrasonic coupling agent A1-A4 and DA1 is carried out performance test, concrete outcome such as table 1 below.
| Performance indications | A1 | A2 | A3 | A4 | DA1 |
| The velocity of sound (35 DEG C) (m/s) | 1580 | 1570 | 1580 | 1550 | 1570 |
| Acoustic characteristic impedance (35 DEG C) (10<sup>6</sup>Pa·s/m) | 1.57 | 1.57 | 1.59 | 1.55 | 1.59 |
| Acoustic attenuation coefficient slope (35 DEG C) dB/ (cm MHz) | 0.012 | 0.014 | 0.013 | 0.019 | 0.062 |
| Viscosity (35 DEG C) Pa s | 20 | 23 | 22 | 27 | 32 |
| PH value | 7.0 | 6.8 | 6.9 | 6.6 | 6.2 |
The velocity of sound is measured under 35 DEG C and 4.0MHz according to the method for GB/T15261, and sample length is 6cm；
Viscosity is rotary viscous according to " Pharmacopoeia of People's Republic of China two " version annex VI G " viscosimetry " in 2010
Degree meter method is measured at 25 DEG C；
PH value is measured according to " Pharmacopoeia of People's Republic of China two " 2010 version annex VI H " pH value algoscopy "；
Acoustic attenuation measures by double sample methods under 35 DEG C and 4.0MHz according to the method in GB/T15261, and with sound in water
Decay is modified, and the difference of two sample lengths is more than 5cm.
Two, ultrasonic coupling agent irritation test
1, Skin Irritation Test
Test method: (2.0 ± 0.2Kg, by Beijing Vital River Experimental Animals Technology Co., Ltd. to take 40 healthy rabbits
There is provided), male and female half and half, at random rabbit is divided into 10 groups of (often group male and female half and half, 5 groups of intact skin groups, 5 groups of wounds according to sex
Skin group), by hair cutting (the unilateral shaving area about 40cm of rabbit spinal column both sides2), and uniform application 10% sodium sulfide is de-
Except residue hair stubble, observe the depilation equal not damaged of skin, carry out modeling.To trauma skin group, with sterilizing No. 16 syringe needles in unhairing
Mark about 2cm on skin #4, not hinder corium, to have slight oozing of blood to be advisable.Test uses own control, and left side does not process and does
On the right side of rabbit in blank, 5 groups of intact skin groups and 5 groups of trauma skin groups unhairing region smear respectively A1, A2, A3, A4,
DA1, uses distilled water to clean after 24 hours, after cleaning, area skin is smeared in 1h, 24h, 48h, 72h perusal, and
There is the situation of erythema and edema in record.
Skin wound repair standards of grading such as table 2.
Table 2
Skin irritation intensity evaluation according to score value is: 0～0.5 is nonirritant；0.5～2.0 is minimal irritation；2.0
～6.0 be moderate zest；6.0～8.0 is strong and stimulating.
The concrete result of the test of skin irritation is as shown in table 3.
Table 3
The ultrasonic coupling agent (the particularly ultrasonic coupling agent in embodiment 1-3) of the present invention is the most right as can be seen from the above table
Intact skin is still to trauma skin all nonirritants.It addition, according to above-mentioned erythema and edema situation, find that the present invention's is ultrasonic
Couplant to intact skin and trauma skin all without sensitization.
Three, ultrasonic coupling agent bactericidal effect test
A1-A4 and DA1 being applied to ultrasonic probe, detects after 2 minutes, testing result is as shown in table 4.
Table 4
Bactericidal property is carried out according to regulation C.3 in GB/T15979-2002 appendix C.
As can be seen from the above table, the ultrasonic coupling agent for medical ultrasonic diagnosis and treatment of the present invention is for various common bacterias all
There is superpower sterilizing ability, thus ensured that ultrasonic probe will not produce iatrogenic sense during frequently using to patient
Dye.
To sum up, the invention provides a kind of ultrasonic coupling agent for medical ultrasonic diagnosis and treatment, this ultrasonic coupling agent has pole
Little acoustic attenuation coefficient and there is strong bactericidal action, it is possible to ensure and high-quality complete ultrasonic medical and prevent Reusability
During nosocomial infection.
Claims (5)
1. the ultrasonic coupling agent for medical ultrasonic diagnosis and treatment, it is characterised in that this ultrasonic coupling agent consists of the following composition:
Chitin morpholine quaternary ammonium salt, Polyethylene Glycol, glycerol, triethanolamine and the water of surplus；Described chitin morpholine quaternary ammonium
Salt is that chitin reacts, with methylglycidyl morpholine quaternary ammonium salt, the product obtained.
Ultrasonic coupling agent for medical ultrasonic diagnosis and treatment the most according to claim 1, it is characterised in that this ultrasonic coupling agent
Weight percentage composition is: chitin morpholine quaternary ammonium salt 2～6%, Polyethylene Glycol 1～5%, glycerol 3～6%, triethanolamine
0.1～0.5% and the water of surplus.
Ultrasonic coupling agent for medical ultrasonic diagnosis and treatment the most according to claim 1 and 2, it is characterised in that described carapace
The preparation method of element morpholine quaternary ammonium salt is: under nitrogen protection, by chitin, methylglycidyl morpholine quaternary ammonium salt, hydroxide
Sodium joins in DMSO 35～45 DEG C and reacts 8～12 hours, is cooled to room temperature, salt acid for adjusting pH to 6～7, and reactant liquor concentrates, first
Alcohol is recrystallized to give chitin morpholine quaternary ammonium salt.
4. according to the ultrasonic coupling agent for medical ultrasonic diagnosis and treatment described in claim 1 or 3, it is characterised in that chitin, first
Basic ring oxygen propylmorpholin quaternary ammonium salt, sodium hydroxide concentration mol ratio are 1:1.5～2:2～3, and wherein chitin is with monomer molecule amount
The amount of substance for calculation.
5. the preparation method of the ultrasonic coupling agent for medical ultrasonic diagnosis and treatment described in any one in claim 1-4, it is special
Levying and be, this preparation method includes:
1) will chitin morpholine quaternary ammonium salt, Polyethylene Glycol, glycerol, triethanolamine and water addition reactor mix,
It is heated to 65 DEG C, is incubated 10 minutes, filter；
2) by step 1) filtrate that is filtrated to get carries out supersound process 5～10min, obtains ultrasonic coupling agent.
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| CN107753961A (en) * | 2017-12-06 | 2018-03-06 | 青岛大学附属医院 | A kind of Color Sonography ultrasonic coupling agent |
| CN108132307A (en) * | 2017-10-26 | 2018-06-08 | 湖南金化科技集团有限公司 | A kind of rail examination industry couplant and preparation method thereof |
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|---|---|---|---|---|
| CN102512696A (en) * | 2011-12-31 | 2012-06-27 | 戴新春 | Medical ultrasonic couplant and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512696A (en) * | 2011-12-31 | 2012-06-27 | 戴新春 | Medical ultrasonic couplant and preparation method thereof |
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| 宋庆平: ""水溶性壳聚糖衍生物的制备及其抗菌性能研究"", 《安徽工程大学硕士学位论文》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108132307A (en) * | 2017-10-26 | 2018-06-08 | 湖南金化科技集团有限公司 | A kind of rail examination industry couplant and preparation method thereof |
| CN108132307B (en) * | 2017-10-26 | 2020-12-04 | 湖南金化科技集团有限公司 | Industrial coupling agent for steel rail flaw detection and preparation method thereof |
| CN107753961A (en) * | 2017-12-06 | 2018-03-06 | 青岛大学附属医院 | A kind of Color Sonography ultrasonic coupling agent |
| CN107753961B (en) * | 2017-12-06 | 2020-09-11 | 青岛大学附属医院 | Heart color ultrasound coupling agent |
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Application publication date: 20161109 |