CN107349436A - A kind of medical water-soluble ultrasonic coupling agent and preparation method thereof - Google Patents
A kind of medical water-soluble ultrasonic coupling agent and preparation method thereof Download PDFInfo
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- CN107349436A CN107349436A CN201710466028.8A CN201710466028A CN107349436A CN 107349436 A CN107349436 A CN 107349436A CN 201710466028 A CN201710466028 A CN 201710466028A CN 107349436 A CN107349436 A CN 107349436A
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- 239000007822 coupling agent Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 67
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 44
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims abstract description 40
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 40
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 38
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 33
- 229960001631 carbomer Drugs 0.000 claims abstract description 33
- 239000012153 distilled water Substances 0.000 claims abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 23
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims abstract description 23
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 23
- 239000011575 calcium Substances 0.000 claims abstract description 23
- 239000000174 gluconic acid Substances 0.000 claims abstract description 23
- 235000012208 gluconic acid Nutrition 0.000 claims abstract description 23
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000011187 glycerol Nutrition 0.000 claims abstract description 22
- 239000000843 powder Substances 0.000 claims abstract description 22
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims abstract description 21
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims abstract description 21
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 claims abstract description 21
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 claims abstract description 21
- 229940074393 chlorogenic acid Drugs 0.000 claims abstract description 21
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 claims abstract description 21
- 235000001368 chlorogenic acid Nutrition 0.000 claims abstract description 21
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 claims abstract description 21
- -1 ether ammonium salt Chemical class 0.000 claims abstract description 21
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims abstract description 21
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims abstract description 21
- 239000009286 sanguis draxonis Substances 0.000 claims abstract description 21
- XXSSNTKMBVTREV-DDHROXKOSA-N C([C@]1(C)[C@@H]2[C@@](C(=C[C@@H](O)C2)CO)(COC(C)=O)CC[C@H]1C)CC1=CC(=O)OC1 Chemical compound C([C@]1(C)[C@@H]2[C@@](C(=C[C@@H](O)C2)CO)(COC(C)=O)CC[C@H]1C)CC1=CC(=O)OC1 XXSSNTKMBVTREV-DDHROXKOSA-N 0.000 claims abstract description 20
- XXSSNTKMBVTREV-UHFFFAOYSA-N blinin Natural products CC1CCC(C(=CC(O)C2)CO)(COC(C)=O)C2C1(C)CCC1=CC(=O)OC1 XXSSNTKMBVTREV-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000004310 lactic acid Substances 0.000 claims abstract description 20
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 20
- OYVWNCFVPCTLFI-UHFFFAOYSA-N C(C)(=O)O.C(C)(=O)O.C(C)(=O)O.C(C)(=O)O.C(C)NCCN(CC)CC Chemical compound C(C)(=O)O.C(C)(=O)O.C(C)(=O)O.C(C)(=O)O.C(C)NCCN(CC)CC OYVWNCFVPCTLFI-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229920002472 Starch Polymers 0.000 claims abstract description 19
- 239000008107 starch Substances 0.000 claims abstract description 19
- 235000019698 starch Nutrition 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 14
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims description 32
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 claims description 5
- 230000008878 coupling Effects 0.000 claims description 5
- 238000010168 coupling process Methods 0.000 claims description 5
- 238000005859 coupling reaction Methods 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
- 229930101531 artemisinin Natural products 0.000 claims 1
- BLUAFEHZUWYNDE-XRNKLDBLSA-N chembl77 Chemical compound C([C@@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4C31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-XRNKLDBLSA-N 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 abstract description 6
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 6
- 238000003745 diagnosis Methods 0.000 abstract description 3
- 229920003081 Povidone K 30 Polymers 0.000 abstract 1
- 229950006191 gluconic acid Drugs 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 230000003013 cytotoxicity Effects 0.000 description 3
- 231100000135 cytotoxicity Toxicity 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229940050526 hydroxyethylstarch Drugs 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
Abstract
The invention provides a kind of medical water-soluble ultrasonic coupling agent, it is prepared by the following raw material：Carbomer, gluconic acid, chlorogenic acid, Sanguis Draxonis powder, Blinin, triethyl ethylenediamine tetraacetic acid (EDTA) calcium, bydroxyethyl starch ether, hydroxymethyl cellulose ether ammonium salt, histidine, natrium adetate, 30 POVIDONE K 30 BP/USP 90, lactic acid, glycerine, distilled water.The present invention also provides the preparation method of the medical water-soluble ultrasonic coupling agent.The ultrasonic attenuation coefficient of ultrasonic coupling agent provided by the invention is small, sterilization speed is fast, toxicity is low, non-stimulated, and can be applied to have the surface of a wound or the incomplete position of skin use, meet very much the demand of practical medical Ultrasonic Diagnosis.
Description
Technical field
The invention belongs to medical supplies technical field, and in particular to a kind of medical water-soluble ultrasonic coupling agent and its preparation side
Method.
Background technology
Medical ultrasonic coupling agent is wide variety of entrant sound intermediary medium in current medical ultrasonic diagnosis and treatment, and its function is to strengthen
Coupling between ultrasonic probe and human body skin, the air completely cut off between ultrasonic probe and examined area skin, passes sound wave
Leading is not influenceed and is decayed by air, to reach accurate clearly inspection result.Because medical supersonic is smaller to human injury, connect
Person under inspection by ultrasonic examination is more, and ultrasonic probe continually can directly be connect in the skin or mucous membrane of different persons under inspection
Touch, content of molds is more, it is likely that triggers the latent dangerous factor of hospital infection.Medical water-soluble ultrasonic coupling agent is not damaged due to it
Hinder ultrasonic probe, be easy to be coated on skin, nonirritant, anaphylaxis, be easy to remove not pollution clothes and in ultrasound detection field
Widely use.However, current water-soluble ultrasonic coupling agent can only play a part of certain isolation air, actual sterilization
It is horizontal limited；Secondly as the frequency of ultrasound detection is fast, the sterilization speed of water-soluble ultrasonic coupling agent it is also proposed more
High requirement, it is desirable to which it can be in short-term rapid sterilization.In addition, existing ultrasonic coupling agent can also be suitable for having the surface of a wound
Or the incomplete position of skin, can not meet the needs of practical medical Ultrasonic Diagnosis.
The content of the invention
Therefore, the present invention provides a kind of medical water-soluble ultrasonic coupling agent and preparation method thereof, solve in the prior art extremely
A kind of few technical problem.
Therefore, the present invention provides a kind of medical water-soluble ultrasonic coupling agent, it is prepared by the raw material of following parts by weight：Card
Ripple nurse 4-12 parts, gluconic acid 1-5 parts, chlorogenic acid 2-5.5 parts, Sanguis Draxonis powder 0.5-1.8 parts, Blinin 0.6-1.5 parts, three second
Ester ethylenediamine tetraacetic acid (EDTA) calcium 2-6 parts, bydroxyethyl starch ether 1-4 parts, hydroxymethyl cellulose ether ammonium salt 2.5-4.8 parts, histidine 1.2-3
Part, natrium adetate 2.4-5 parts, PVP K-90 4.2-9 parts, lactic acid 2.6-5 parts, glycerine 15-24 parts, distilled water 38-50
Part.
According to an embodiment of the invention, wherein, the carbomer is Acritamer 940, Carbopol and carbomer
One or more in 941.
According to an embodiment of the invention, wherein, it is prepared by the raw material of following parts by weight：Carbomer 4.8-11
Part, gluconic acid 1.6-4.2 parts, chlorogenic acid 2.4-5 parts, Sanguis Draxonis powder 0.7-1.5 parts, Blinin 0.8-1.2 parts, triethyl two
Amine tetraacethyl calcium 2.4-5.3 parts, bydroxyethyl starch ether 1.8-3.4 parts, hydroxymethyl cellulose ether ammonium salt 2.8-4.4 parts, histidine
1.5-2.7 parts, natrium adetate 2.6-4.8 parts, PVP K-90 5.7-8.2 parts, lactic acid 3.1-4.6 parts, glycerine 18-22
Part, distilled water 40-47 parts.
According to an embodiment of the invention, wherein, it is prepared by the raw material of following parts by weight：7.9 parts of carbomer,
2.6 parts of gluconic acid, 3.5 parts of chlorogenic acid, 1.4 parts of Sanguis Draxonis powder, 1.1 parts of Blinin, 3 parts of triethyl ethylenediamine tetraacetic acid (EDTA) calcium, hydroxyl
2.5 parts of hydroxyethyl starch ether, 3.6 parts of hydroxymethyl cellulose ether ammonium salt, 2.1 parts of histidine, 3 parts of natrium adetate, PVP K-90
6.2 parts, 4.2 parts of lactic acid, 20 parts of glycerine, 44 parts of distilled water.
Therefore, the present invention provides the preparation method of described medical water-soluble ultrasonic coupling agent, comprise the following steps：
Step 1, carbomer and PVP K-90 added in half distilled water, it is small with 50-200 revs/min of rotating speed stirring 12-36
When, it is standby；
Step 2, chlorogenic acid, Sanguis Draxonis powder, lactic acid, histidine, natrium adetate, bydroxyethyl starch ether added into remaining distilled water
In, 60-80 DEG C is heated to, 1-3 hours is stirred, is cooled to room temperature, it is standby；
Step 3, by Blinin, gluconic acid, triethyl ethylenediamine tetraacetic acid (EDTA) calcium, hydroxymethyl cellulose ether ammonium salt add glycerine
In, 1-4 hours are stirred at room temperature with 500-1500 revs/min of rotating speed；
Step 4, solution made from step 2 is slowly added in step 1, continues to stir 15-50 with 200-500 revs/min of rotating speed
Minute, solution made from adding step 3 is continued thereafter with, continues to stir 30-60 minutes, that is, medical water-soluble ultrasonic coupling is made
Agent.
According to an embodiment of the invention, wherein, stirred 28 hours with 80 revs/min of rotating speed in the step 1；Institute
State and 75 DEG C are heated in step 2, stir 3 hours.
According to an embodiment of the invention, wherein, it is small with 1200 revs/min of rotating speed to be stirred at room temperature 3 in the step 3
When.
According to an embodiment of the invention, wherein, 30 points of stirring is continued with 350 revs/min of rotating speed in the step 4
Clock；Continue stirring 45 minutes in the step 4.
Beneficial effects of the present invention are：
The ultrasonic attenuation coefficient of ultrasonic coupling agent provided by the invention is between 0.017-0.034 dB/cm/MHz, hence it is evident that low
In≤0.05 standard requirement, while bactericidal property of the smearing after 15 seconds, up to more than 72.5%, its bactericidal property reaches after smearing 30 seconds
More than 93%, sterilization speed is fast, and vitro cytotoxicity grade is less than 1 grade.In addition, ultrasonic coupling provided by the present invention
Mixture is non-stimulated to skin, and can be applied to the to have a surface of a wound or incomplete position of skin uses, and meets very much practical medical and surpasses
The demand of audio clinic.
Embodiment
With reference to specific embodiment, the present invention is described in further detail.Following examples are used to illustrate the present invention,
But it is not limited to the scope of the present invention.
Embodiment 1
A kind of medical water-soluble ultrasonic coupling agent, is prepared by the raw material of following parts by weight：4 parts of carbomer, gluconic acid 1
Part, 2 parts of chlorogenic acid, 0.5 part of Sanguis Draxonis powder, 0.6 part of Blinin, 2 parts of triethyl ethylenediamine tetraacetic acid (EDTA) calcium, 1 part of bydroxyethyl starch ether,
2.5 parts of hydroxymethyl cellulose ether ammonium salt, 1.2 parts of histidine, 2.4 parts of natrium adetate, 4.2 parts of PVP K-90, lactic acid 2.6
Part, 15 parts of glycerine, 38 parts of distilled water.
Wherein, the carbomer is Acritamer 940.
The present invention provides the preparation method of described medical water-soluble ultrasonic coupling agent, comprises the following steps：
Step 1, carbomer and PVP K-90 added in half distilled water, stirred 12 hours with 50 revs/min of rotating speed, it is standby
With；
Step 2, chlorogenic acid, Sanguis Draxonis powder, lactic acid, histidine, natrium adetate, bydroxyethyl starch ether added into remaining distilled water
In, 60 DEG C are heated to, stirs 1 hour, is cooled to room temperature, it is standby；
Step 3, by Blinin, gluconic acid, triethyl ethylenediamine tetraacetic acid (EDTA) calcium, hydroxymethyl cellulose ether ammonium salt add glycerine
In, it is stirred at room temperature 1 hour with 500 revs/min of rotating speed；
Step 4, solution made from step 2 is slowly added in step 1, stirring 15 minutes is continued with 200 revs/min of rotating speed, with
After continuously add solution made from step 3, continue stirring 30 minutes, that is, be made medical water-soluble ultrasonic coupling agent.
Embodiment 2
A kind of medical water-soluble ultrasonic coupling agent, is prepared by the raw material of following parts by weight：12 parts of carbomer, gluconic acid 5
Part, 5.5 parts of chlorogenic acid, 1.8 parts of Sanguis Draxonis powder, 1.5 parts of Blinin, 6 parts of triethyl ethylenediamine tetraacetic acid (EDTA) calcium, bydroxyethyl starch ether 4
Part, 4.8 parts of hydroxymethyl cellulose ether ammonium salt, 3 parts of histidine, 5 parts of natrium adetate, 9 parts of PVP K-90,5 parts of lactic acid, third
24 parts of triol, 50 parts of distilled water.
Wherein, the carbomer is that mass ratio is 1:3 Carbopol and Carbopol 941.
The present invention provides the preparation method of described medical water-soluble ultrasonic coupling agent, comprises the following steps：
Step 1, carbomer and PVP K-90 added in half distilled water, stirred 36 hours with 200 revs/min of rotating speed, it is standby
With；
Step 2, chlorogenic acid, Sanguis Draxonis powder, lactic acid, histidine, natrium adetate, bydroxyethyl starch ether added into remaining distilled water
In, 80 DEG C are heated to, stirs 3 hours, is cooled to room temperature, it is standby；
Step 3, by Blinin, gluconic acid, triethyl ethylenediamine tetraacetic acid (EDTA) calcium, hydroxymethyl cellulose ether ammonium salt add glycerine
In, it is stirred at room temperature 4 hours with 1500 revs/min of rotating speed；
Step 4, solution made from step 2 is slowly added in step 1, stirring 50 minutes is continued with 500 revs/min of rotating speed, with
After continuously add solution made from step 3, continue stirring 60 minutes, that is, be made medical water-soluble ultrasonic coupling agent.
Embodiment 3
A kind of medical water-soluble ultrasonic coupling agent, is prepared by the raw material of following parts by weight：4.8 parts of carbomer, gluconic acid
1.6 parts, 2.4 parts of chlorogenic acid, 0.7 part of Sanguis Draxonis powder, 0.8 part of Blinin, 2.4 parts of triethyl ethylenediamine tetraacetic acid (EDTA) calcium, ethoxy form sediment
1.8 parts of powder ether, 2.8 parts of hydroxymethyl cellulose ether ammonium salt, 1.5 parts of histidine, 2.6 parts of natrium adetate, PVP K-90 5.7
Part, 3.1 parts of lactic acid, 18 parts of glycerine, 40 parts of distilled water.
Wherein, the carbomer is that mass ratio is 1:1 Acritamer 940 and Carbopol 941.
The present invention provides the preparation method of described medical water-soluble ultrasonic coupling agent, comprises the following steps：
Step 1, carbomer and PVP K-90 added in half distilled water, stirred 24 hours with 150 revs/min of rotating speed, it is standby
With；
Step 2, chlorogenic acid, Sanguis Draxonis powder, lactic acid, histidine, natrium adetate, bydroxyethyl starch ether added into remaining distilled water
In, 7 DEG C are heated to, stirs 2 hours, is cooled to room temperature, it is standby；
Step 3, by Blinin, gluconic acid, triethyl ethylenediamine tetraacetic acid (EDTA) calcium, hydroxymethyl cellulose ether ammonium salt add glycerine
In, it is stirred at room temperature 3 hours with 800 revs/min of rotating speed；
Step 4, solution made from step 2 is slowly added in step 1, stirring 30 minutes is continued with 350 revs/min of rotating speed, with
After continuously add solution made from step 3, continue stirring 45 minutes, that is, be made medical water-soluble ultrasonic coupling agent.
Embodiment 4
A kind of medical water-soluble ultrasonic coupling agent, is prepared by the raw material of following parts by weight：11 parts of carbomer, gluconic acid
4.2 parts, 5 parts of chlorogenic acid, 1.5 parts of Sanguis Draxonis powder, 1.2 parts of Blinin, 5.3 parts of triethyl ethylenediamine tetraacetic acid (EDTA) calcium, HES
3.4 parts of ether, 4.4 parts of hydroxymethyl cellulose ether ammonium salt, 2.7 parts of histidine, 4.8 parts of natrium adetate, 8.2 parts of PVP K-90,
4.6 parts of lactic acid, 22 parts of glycerine, 47 parts of distilled water.
Wherein, the carbomer is that mass ratio is 1:2:1 Acritamer 940, Carbopol and Carbopol 941.
The present invention provides the preparation method of described medical water-soluble ultrasonic coupling agent, comprises the following steps：
Step 1, carbomer and PVP K-90 added in half distilled water, stirred 20 hours with 180 revs/min of rotating speed, it is standby
With；
Step 2, chlorogenic acid, Sanguis Draxonis powder, lactic acid, histidine, natrium adetate, bydroxyethyl starch ether added into remaining distilled water
In, 75 DEG C are heated to, stirs 3 hours, is cooled to room temperature, it is standby；
Step 3, by Blinin, gluconic acid, triethyl ethylenediamine tetraacetic acid (EDTA) calcium, hydroxymethyl cellulose ether ammonium salt add glycerine
In, 1-4 hours are stirred at room temperature with 800 revs/min of rotating speed；
Step 4, solution made from step 2 is slowly added in step 1, stirring 20 minutes is continued with 400 revs/min of rotating speed, with
After continuously add solution made from step 3, continue stirring 45 minutes, that is, be made medical water-soluble ultrasonic coupling agent.
Embodiment 5
A kind of medical water-soluble ultrasonic coupling agent, is prepared by the raw material of following parts by weight：7.9 parts of carbomer, gluconic acid
2.6 parts, 3.5 parts of chlorogenic acid, 1.4 parts of Sanguis Draxonis powder, 1.1 parts of Blinin, 3 parts of triethyl ethylenediamine tetraacetic acid (EDTA) calcium, HES
2.5 parts of ether, 3.6 parts of hydroxymethyl cellulose ether ammonium salt, 2.1 parts of histidine, 3 parts of natrium adetate, 6.2 parts of PVP K-90, breast
4.2 parts of acid, 20 parts of glycerine, 44 parts of distilled water.
Wherein, the carbomer is that mass ratio is 2:1:4 Acritamer 940, Carbopol and Carbopol 941.
The present invention provides the preparation method of described medical water-soluble ultrasonic coupling agent, comprises the following steps：
Step 1, carbomer and PVP K-90 added in half distilled water, stirred 28 hours with 80 revs/min of rotating speed, it is standby
With；
Step 2, chlorogenic acid, Sanguis Draxonis powder, lactic acid, histidine, natrium adetate, bydroxyethyl starch ether added into remaining distilled water
In, 75 DEG C are heated to, stirs 3 hours, is cooled to room temperature, it is standby；
Step 3, by Blinin, gluconic acid, triethyl ethylenediamine tetraacetic acid (EDTA) calcium, hydroxymethyl cellulose ether ammonium salt add glycerine
In, it is small that 1200 revs/min of rotating speed is stirred at room temperature 3；
Step 4, solution made from step 2 is slowly added in step 1, stirring 30 minutes is continued with 350 revs/min of rotating speed, with
After continuously add solution made from step 3, continue stirring 45 minutes, that is, be made medical water-soluble ultrasonic coupling agent.
Comparative example 1
A kind of medical water-soluble ultrasonic coupling agent, is prepared by the raw material of following parts by weight：4 parts of carbomer, gluconic acid 1
Part, 0.6 part of Blinin, 2 parts of triethyl ethylenediamine tetraacetic acid (EDTA) calcium, 1 part of bydroxyethyl starch ether, 2.5 parts of hydroxymethyl cellulose ether ammonium salt,
2.4 parts of natrium adetate, 4.2 parts of PVP K-90,2.6 parts of lactic acid, 15 parts of glycerine, 38 parts of distilled water.
Wherein, the carbomer is Acritamer 940.
The present invention provides the preparation method of described medical water-soluble ultrasonic coupling agent, comprises the following steps：
Step 1, carbomer and PVP K-90 added in half distilled water, stirred 12 hours with 50 revs/min of rotating speed, it is standby
With；
Step 2, lactic acid, natrium adetate, bydroxyethyl starch ether added in remaining distilled water, be heated to 60 DEG C, stirring 1 is small
When, room temperature is cooled to, it is standby；
Step 3, by Blinin, gluconic acid, triethyl ethylenediamine tetraacetic acid (EDTA) calcium, hydroxymethyl cellulose ether ammonium salt add glycerine
In, it is stirred at room temperature 1 hour with 500 revs/min of rotating speed；
Step 4, solution made from step 2 is slowly added in step 1, stirring 15 minutes is continued with 200 revs/min of rotating speed, with
After continuously add solution made from step 3, continue stirring 30 minutes, that is, be made medical water-soluble ultrasonic coupling agent.
Comparative example 2
A kind of medical water-soluble ultrasonic coupling agent, is prepared by the raw material of following parts by weight：4 parts of carbomer, gluconic acid 1
Part, 2 parts of chlorogenic acid, 0.5 part of Sanguis Draxonis powder, 2 parts of triethyl ethylenediamine tetraacetic acid (EDTA) calcium, 1 part of bydroxyethyl starch ether, 1.2 parts of histidine,
2.4 parts of natrium adetate, 4.2 parts of PVP K-90,15 parts of glycerine, 38 parts of distilled water.
Wherein, the carbomer is Acritamer 940.
The present invention provides the preparation method of described medical water-soluble ultrasonic coupling agent, comprises the following steps：
Step 1, carbomer and PVP K-90 added in half distilled water, stirred 12 hours with 50 revs/min of rotating speed, it is standby
With；
Step 2, chlorogenic acid, Sanguis Draxonis powder, histidine, natrium adetate, bydroxyethyl starch ether added in remaining distilled water, added
Heat stirs 1 hour to 60 DEG C, is cooled to room temperature, standby；
Step 3, by gluconic acid, triethyl ethylenediamine tetraacetic acid (EDTA) calcium add glycerine in, be stirred at room temperature 1 with 500 revs/min of rotating speed
Hour；
Step 4, solution made from step 2 is slowly added in step 1, stirring 15 minutes is continued with 200 revs/min of rotating speed, with
After continuously add solution made from step 3, continue stirring 30 minutes, that is, be made medical water-soluble ultrasonic coupling agent.
Performance test
Following performance test is carried out to the ultrasonic coupling agent prepared by embodiment 1-5 and comparative example 1,2, its method of testing is with reference to this
The universal method of Product checking, test result such as following table：
| Ultrasonic attenuation coefficient/dB/cm/MHz | Bactericidal property/%（After smearing 15 seconds） | Bactericidal property/%（After smearing 30 seconds） | Vitro cytotoxicity grade | |
| Embodiment 1 | 0.034 | 72.5 | 93.5 | 0 grade |
| Embodiment 2 | 0.028 | 78.3 | 94.7 | 0 grade |
| Embodiment 3 | 0.026 | 80.1 | 95.1 | 0 grade |
| Embodiment 4 | 0.021 | 82.6 | 96.3 | 0 grade |
| Embodiment 5 | 0.017 | 83.4 | 97.8 | 0 grade |
| Comparative example 1 | 0.042 | 60.6 | 83.6 | 0 grade |
| Comparative example 2 | 0.039 | 61.3 | 81.8 | 0 grade |
The ultrasonic attenuation coefficient of ultrasonic coupling agent provided by the invention is between 0.017-0.034 dB/cm/MHz, hence it is evident that low
In≤0.05 standard requirement, while bactericidal property of the smearing after 15 seconds, up to more than 72.5%, its bactericidal property reaches after smearing 30 seconds
More than 93%, sterilization speed is fast, and vitro cytotoxicity grade is less than 1 grade.In addition, ultrasonic coupling provided by the present invention
Mixture is non-stimulated to skin, and can be applied to the to have a surface of a wound or incomplete position of skin uses, and meets very much practical medical and surpasses
The demand of audio clinic.
Claims (8)
1. a kind of medical water-soluble ultrasonic coupling agent, it is characterised in that be prepared by the raw material of following parts by weight：Carbomer
4-12 parts, gluconic acid 1-5 parts, chlorogenic acid 2-5.5 parts, Sanguis Draxonis powder 0.5-1.8 parts, Blinin 0.6-1.5 parts, triethyl two
Amine tetraacethyl calcium 2-6 parts, bydroxyethyl starch ether 1-4 parts, hydroxymethyl cellulose ether ammonium salt 2.5-4.8 parts, histidine 1.2-3 parts,
Natrium adetate 2.4-5 parts, PVP K-90 4.2-9 parts, lactic acid 2.6-5 parts, glycerine 15-24 parts, distilled water 38-50 parts.
2. medical water-soluble ultrasonic coupling agent according to claim 1, it is characterised in that the carbomer is carbomer
940th, the one or more in Carbopol and Carbopol 941.
3. medical water-soluble ultrasonic coupling agent according to claim 1, it is characterised in that by the raw material of following parts by weight
It is prepared：Carbomer 4.8-11 parts, gluconic acid 1.6-4.2 parts, chlorogenic acid 2.4-5 parts, Sanguis Draxonis powder 0.7-1.5 parts, hardship
Artemisin 0.8-1.2 parts, triethyl ethylenediamine tetraacetic acid (EDTA) calcium 2.4-5.3 parts, bydroxyethyl starch ether 1.8-3.4 parts, hydroxymethyl cellulose
Ether ammonium salt 2.8-4.4 parts, histidine 1.5-2.7 parts, natrium adetate 2.6-4.8 parts, PVP K-90 5.7-8.2 parts, lactic acid
3.1-4.6 parts, glycerine 18-22 parts, distilled water 40-47 parts.
4. medical water-soluble ultrasonic coupling agent according to claim 1, it is characterised in that by the raw material of following parts by weight
It is prepared：7.9 parts of carbomer, 2.6 parts of gluconic acid, 3.5 parts of chlorogenic acid, 1.4 parts of Sanguis Draxonis powder, 1.1 parts of Blinin, three second
3 parts of ester ethylenediamine tetraacetic acid (EDTA) calcium, 2.5 parts of bydroxyethyl starch ether, 3.6 parts of hydroxymethyl cellulose ether ammonium salt, 2.1 parts of histidine, according to ground
3 parts of acid disodium, 6.2 parts of PVP K-90,4.2 parts of lactic acid, 20 parts of glycerine, 44 parts of distilled water.
5. the preparation method of the medical water-soluble ultrasonic coupling agent as described in claim 1-4 is any, it is characterised in that including such as
Lower step：
Step 1, carbomer and PVP K-90 added in half distilled water, it is small with 50-200 revs/min of rotating speed stirring 12-36
When, it is standby；
Step 2, chlorogenic acid, Sanguis Draxonis powder, lactic acid, histidine, natrium adetate, bydroxyethyl starch ether added into remaining distilled water
In, 60-80 DEG C is heated to, 1-3 hours is stirred, is cooled to room temperature, it is standby；
Step 3, by Blinin, gluconic acid, triethyl ethylenediamine tetraacetic acid (EDTA) calcium, hydroxymethyl cellulose ether ammonium salt add glycerine
In, 1-4 hours are stirred at room temperature with 500-1500 revs/min of rotating speed；
Step 4, solution made from step 2 is slowly added in step 1, continues to stir 15-50 with 200-500 revs/min of rotating speed
Minute, solution made from adding step 3 is continued thereafter with, continues to stir 30-60 minutes, that is, medical water-soluble ultrasonic coupling is made
Agent.
6. the preparation method of medical water-soluble ultrasonic coupling agent according to claim 5, it is characterised in that the step 1
In stirred 28 hours with 80 revs/min of rotating speed；75 DEG C are heated in the step 2, is stirred 3 hours.
7. the preparation method of medical water-soluble ultrasonic coupling agent according to claim 5, it is characterised in that the step 3
In be stirred at room temperature 3 hours with 1200 revs/min of rotating speed.
8. the preparation method of medical water-soluble ultrasonic coupling agent according to claim 5, it is characterised in that the step 4
In with 350 revs/min of rotating speed continue stirring 30 minutes；Continue stirring 45 minutes in the step 4.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108359520A (en) * | 2018-04-02 | 2018-08-03 | 常州海纳金属助剂有限公司 | A kind of Environment-friendlyantirust antirust defect detecting liquid and preparation method thereof |
| WO2020020114A1 (en) * | 2018-07-25 | 2020-01-30 | 苏州安德佳生物科技有限公司 | Biocompatible ultrasonic coupling agent for endoscope and use thereof |
| US11213615B2 (en) | 2017-02-28 | 2022-01-04 | EndoClot Plus Co.. Ltd | Composition for submucosal injection, reagent combination, and applications thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104667302A (en) * | 2013-11-26 | 2015-06-03 | 沈攀攀 | A medical ultrasonic coupling agent and a preparing method thereof |
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2017
- 2017-06-19 CN CN201710466028.8A patent/CN107349436A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104667302A (en) * | 2013-11-26 | 2015-06-03 | 沈攀攀 | A medical ultrasonic coupling agent and a preparing method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11213615B2 (en) | 2017-02-28 | 2022-01-04 | EndoClot Plus Co.. Ltd | Composition for submucosal injection, reagent combination, and applications thereof |
| CN108359520A (en) * | 2018-04-02 | 2018-08-03 | 常州海纳金属助剂有限公司 | A kind of Environment-friendlyantirust antirust defect detecting liquid and preparation method thereof |
| WO2020020114A1 (en) * | 2018-07-25 | 2020-01-30 | 苏州安德佳生物科技有限公司 | Biocompatible ultrasonic coupling agent for endoscope and use thereof |
| CN110755644A (en) * | 2018-07-25 | 2020-02-07 | 苏州安德佳生物科技有限公司 | Biocompatible ultrasonic coupling agent for endoscope and application thereof |
| CN110755644B (en) * | 2018-07-25 | 2023-06-16 | 苏州安德佳生物科技有限公司 | Biocompatible ultrasonic coupling agent for endoscope and application thereof |
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Application publication date: 20171117 |