CN102512696A - Medical ultrasonic couplant and preparation method thereof - Google Patents
Medical ultrasonic couplant and preparation method thereof Download PDFInfo
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- CN102512696A CN102512696A CN2011104574764A CN201110457476A CN102512696A CN 102512696 A CN102512696 A CN 102512696A CN 2011104574764 A CN2011104574764 A CN 2011104574764A CN 201110457476 A CN201110457476 A CN 201110457476A CN 102512696 A CN102512696 A CN 102512696A
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Abstract
The invention relates to a medical ultrasonic couplant, which comprises one viscosity regulator of hydroxyethyl cellulose, Carbomer and hydroxy propyl cellulose or a composition of the hydroxyethyl cellulose, the Carbomer and the hydroxy propyl cellulose, propylene glycol and sterile deionized water. The medical ultrasonic couplant contains an antimicrobial agent and also comprises any one of vitamin B5 and vitamin E or a composition prepared from the vitamin B5 and the vitamin E in any proportion. The medical ultrasonic couplant is characterized in that the antimicrobial agent is Triclosan, and the medical ultrasonic couplant also comprises chitosan. According to the medical ultrasonic couplant, the Triclosan has a broad-spectrum antimicrobial action; the vitamin B5 and the vitamin E have effects of moistening skins and relieving skin irritations; and the chitosan has effects of blood coagulation and blood stop, and for skin damages, the chitosan has a positive effect on promoting wound healing after postoperative type-B ultrasonic detection is performed on patients. The medical ultrasonic couplant is more suitable for contacting with the skins and has lower cost. The invention also provides a preparation method for the medical ultrasonic couplant.
Description
Technical field
The present invention relates to a kind of medical ultrasonic coupling agent that ultrasonic diagnosis and when treatment use and preparation method thereof that is used for.
Background technology
In the prior art, the medical ultrasonic coupling agent that is usually used in the clinical ultrasound Clinics and Practices is mainly formulated by wherein a kind of viscosity modifier, propylene glycol solvent and sterile deionized water such as hydroxyethyl-cellulose, carbomer, hydroxypropyl celluloses.It plays coupling between sound head (ultrasonic probe or treatment head) and measured object, sound wave is got in the body smoothly, to obtain reliable image or to reach the tissue of treatment.Its basic demand is to transmit sound wave effectively, and specific acoustic impedance is between the specific acoustic impedance of sound head and tissue, and their can proper fit; And it is little to SATT; Be beneficial to and obtain distinct image or effectively reach the required degree of depth of treatment,, be prone to be coated with exhibition the sound head not damaged; To human non-toxic, non-stimulated, be prone to clean.Because sound head contacts with different patients' detection or therapentic part continually; Be easy to generate cross infection; Chinese patent 200810026888.0 has proposed the patent application that name is called " medical ultrasonic coupling agent and preparation method thereof "; Its technical scheme is: a kind of medical ultrasonic coupling agent comprises wherein a kind of viscosity modifier of hydroxyethyl-cellulose, carbomer, hydroxypropyl cellulose; Propylene glycol and sterile deionized water wherein also contain 0.05～0.15% antibacterial, and described antibacterial component is selected from the combination of poly hexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, Trichlorophenoxy diphenyl ether, nanometer silver any one or they.The method for preparing of this medical ultrasonic coupling agent is: hydroxyethyl-cellulose is scattered in the propylene glycol, adds capacity sterile deionized water dispersed with stirring, be heated to 75～80 ℃; Insulation 30min treats liquid-transparent, is cooled to 45 ℃; Add antibacterial, stirring is cooled to canned.The weak point of prior art is: its antibacterial cost of selecting for use is high, and in addition, above-mentioned medical ultrasonic coupling agent has the part crowd that couplant is had anaphylaxis because viscosity modifier has certain zest to skin, phenomenons such as red swelling of the skin occur; Need improve.
Summary of the invention
The present invention aims to provide a kind of medical ultrasonic coupling agent that more is applicable to skin.
Technical solution of the present invention is following:
A kind of medical ultrasonic coupling agent; Comprise wherein a kind of viscosity modifier of hydroxyethyl-cellulose, carbomer, hydroxypropyl cellulose or its combination; Propylene glycol and sterile deionized water contain antibacterial, and it also comprises the combination of arbitrary proportion of any one or they of vitamin B5, vitamin E; It is characterized in that: said antibacterial is a triclosan, and it also comprises chitosan.
The present invention is owing to adopt technique scheme, triclosan (2,4; 4'～trichlorine～2 hydroxyls～diphenyl ether), triclosan has broad-spectrum antibacterial action, and vitamin B5, vitamin E have moistened skin; Alleviated the zest to skin, chitosan has blood coagulation, anastalsis, does B ultrasonic for skin injury such as postoperative patient; To promoting that wound healing has positive role, realized goal of the invention easily.
Further technical scheme is:
The ratio (quality) of the shared whole couplant of said triclosan is 0.08～0.16%, and the ratio (quality) that chitosan accounts for whole couplant is 0.08～0.16%.
The present invention is owing to adopt technique scheme, and the cost of material is low, realized goal of the invention easily.
The object of the invention is also providing the method for preparing of above-mentioned medical ultrasonic coupling agent.
The method for preparing above-mentioned medical ultrasonic coupling agent is:
Wherein a kind of or its combination is scattered in the propylene glycol with an amount of hydroxyethyl-cellulose, carbomer, hydroxypropyl cellulose, adds capacity sterile deionized water dispersed with stirring, and heating is insulation also, treats liquid-transparent, is cooled to room temperature; Any one or its combination of an amount of triclosan, chitosan and vitamin B5, vitamin E added in the sterile deionized water stir; The solution that above two steps are made mixes and stirs; After the mixing; The combination of any one of vitamin B5, vitamin E or their arbitrary proportion accounts for 1 of whole couplant quality～3 ‰; The ratio of the shared whole couplant of triclosan (quality) is 0.08～0.16%, and the ratio (quality) that chitosan accounts for whole couplant is 0.08～0.16%, and is canned.
Above-mentioned heating-up temperature can be 75～80 ℃, and temperature retention time can be 20～40min, so that dissolving is more abundant, more stable.
The specific embodiment
Below alleged mass ratio for add the ratio that thing accounts for the quality of the whole couplant mixture of finally processing.
Embodiment 1:
A kind of medical ultrasonic coupling agent comprises hydroxyethyl-cellulose, propylene glycol and sterile deionized water, and it also comprises the triclosan of the vitamin B5,0.08% (mass ratio) of 1 ‰ (mass ratioes), 0.08% chitosan.The method for preparing above-mentioned medical ultrasonic coupling agent is: an amount of hydroxyethyl-cellulose is scattered in the propylene glycol, adds capacity sterile deionized water dispersed with stirring, be heated to 75 ℃, insulation 20min treats liquid-transparent, is cooled to room temperature; With stirring in an amount of triclosan, chitosan and vitamin B5, the vitamin E adding sterile deionized water; The solution that above two steps are made mixes and stirs; After the mixing, the combination of vitamin B5, vitamin E accounts for 1 ‰ of whole couplant quality, and the ratio of the shared whole couplant of triclosan (quality) is 0.08%; The ratio (quality) that chitosan accounts for whole couplant is 0.08%, and is canned.
Embodiment 2:
A kind of medical ultrasonic coupling agent comprises carbomer, propylene glycol and sterile deionized water, and it also comprises the triclosan of the vitamin B5,0.16% (mass ratio) of 3 ‰ (mass ratioes), 0.16% chitosan.The method for preparing above-mentioned medical ultrasonic coupling agent is: an amount of carbomer is scattered in the propylene glycol, adds capacity sterile deionized water dispersed with stirring, be heated to 80 ℃, insulation 30min treats liquid-transparent, is cooled to room temperature; With stirring in an amount of triclosan, chitosan and the vitamin B5 adding sterile deionized water; The solution that above two steps are made mixes and stirs; After the mixing, vitamin B5 accounts for 3 ‰ of whole couplant quality, and the ratio of the shared whole couplant of triclosan (quality) is 0.16%; The ratio (quality) that chitosan accounts for whole couplant is 0.16%, and is canned.
Embodiment 3:
A kind of medical ultrasonic coupling agent comprises hydroxypropyl cellulose, propylene glycol and sterile deionized water, and it also comprises the chitosan of triclosan, 0.08% (mass ratio) of the vitamin E, 0.16% (mass ratio) of 1 ‰ (mass ratioes).The method for preparing above-mentioned medical ultrasonic coupling agent is: an amount of hydroxypropyl cellulose is scattered in the propylene glycol, adds capacity sterile deionized water dispersed with stirring, be heated to 80 ℃, insulation 40min treats liquid-transparent, is cooled to room temperature; Any one or its combination of an amount of triclosan, chitosan and vitamin E added in the sterile deionized water stir; The solution that above two steps are made mixes and stirs; After the mixing; The combination of any one of vitamin B5, vitamin E or their arbitrary proportion accounts for 1 ‰ of whole couplant quality; The ratio of the shared whole couplant of triclosan (quality) is 0.16%, and the ratio (quality) that chitosan accounts for whole couplant is 0.08%, and is canned.
Embodiment 4:
A kind of medical ultrasonic coupling agent comprises hydroxyethyl-cellulose, carbomer, propylene glycol and sterile deionized water, and it also comprises the triclosan of the vitamin E, 0.08% (mass ratio) of 3 ‰ (mass ratioes), 0.16% chitosan.The method for preparing above-mentioned medical ultrasonic coupling agent is: an amount of hydroxyethyl-cellulose, carbomer combination are scattered in the propylene glycol, add capacity sterile deionized water dispersed with stirring, be heated to 80 ℃, insulation 30min treats liquid-transparent, is cooled to room temperature; With stirring in an amount of triclosan, chitosan and the vitamin E adding sterile deionized water; The solution that above two steps are made mixes and stirs; After the mixing, vitamin B5, vitamin E account for 3 ‰ of whole couplant quality, and the ratio of the shared whole couplant of triclosan (quality) is 0.08%; The ratio (quality) that chitosan accounts for whole couplant is 0.16%, and is canned.
Embodiment 5:
A kind of medical ultrasonic coupling agent comprises carbomer, propylene glycol and sterile deionized water, and it also comprises the triclosan of the vitamin E, 0.1% (mass ratio) of 1 ‰ (mass ratioes), 0.1% chitosan.The method for preparing above-mentioned medical ultrasonic coupling agent is:
An amount of carbomer is scattered in the propylene glycol, adds capacity sterile deionized water dispersed with stirring, be heated to 75 ℃, insulation 30min treats liquid-transparent, is cooled to room temperature; With stirring in an amount of triclosan, chitosan and the vitamin E adding sterile deionized water; The solution that above two steps are made mixes and stirs; After the mixing, vitamin B5, vitamin E account for 1 ‰ of whole couplant quality, and the ratio of the shared whole couplant of triclosan (quality) is 0.1%; The ratio (quality) that chitosan accounts for whole couplant is 0.1%, and is canned.
The foregoing description bactericidal effect is outstanding, and is cheap, and suitable and contact skin.Zest to skin is little, and blood coagulation, anastalsis are arranged, and to promoting that wound healing has positive role, has realized goal of the invention easily.
Method for preparing is also very simple.
The foregoing description only is used to explain the present invention, and protection scope of the present invention is not constituted any limitation.
Certainly, under inventive concept of the present invention, the present invention has multiple form of implementation and is equal to replacement scheme, and this reads and need not pay creative work after this description and can reveal again to those skilled in the art, has not just detailed at this.Adopt the above-mentioned replacement scheme that is equal to fall into protection scope of the present invention certainly.
Claims (4)
1. medical ultrasonic coupling agent; Comprise wherein a kind of viscosity modifier of hydroxyethyl-cellulose, carbomer, hydroxypropyl cellulose or its combination; Propylene glycol and sterile deionized water contain antibacterial, and it also comprises the combination of arbitrary proportion of any one or they of vitamin B5, vitamin E; It is characterized in that: said antibacterial is a triclosan, and it also comprises chitosan.
2. medical ultrasonic coupling agent according to claim 1 is characterized in that: the ratio (quality) of the shared whole couplant of said triclosan is 0.08～0.16%, and the ratio (quality) that chitosan accounts for whole couplant is 0.08～0.16%.
3. the method for preparing above-mentioned medical ultrasonic coupling agent is: wherein a kind of or its combination is scattered in the propylene glycol with an amount of hydroxyethyl-cellulose, carbomer, hydroxypropyl cellulose; Add capacity sterile deionized water dispersed with stirring; Liquid-transparent is treated in heating and insulation, is cooled to room temperature; Any one or its combination of an amount of triclosan, chitosan and vitamin B5, vitamin E added in the sterile deionized water stir; The solution that above two steps are made mixes and stirs; After the mixing; The combination of any one of vitamin B5, vitamin E or their arbitrary proportion accounts for 1 of whole couplant quality～3 ‰; The ratio of the shared whole couplant of triclosan (quality) is 0.08～0.16%, and the ratio (quality) that chitosan accounts for whole couplant is 0.08～0.16%, and is canned.
4. the method for the above-mentioned medical ultrasonic coupling agent of preparation according to claim 3 is characterized in that: be heated to 75～80 ℃, insulation 20～40min.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011104574764A CN102512696A (en) | 2011-12-31 | 2011-12-31 | Medical ultrasonic couplant and preparation method thereof |
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| CN2011104574764A CN102512696A (en) | 2011-12-31 | 2011-12-31 | Medical ultrasonic couplant and preparation method thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194697A (en) * | 2015-11-05 | 2015-12-30 | 济宁博联生物科技有限公司 | Medical ultrasonic coupling agent and preparation method thereof |
| CN106075483A (en) * | 2016-08-16 | 2016-11-09 | 青岛云天生物技术有限公司 | A kind of ultrasonic coupling agent for medical ultrasonic diagnosis and treatment and preparation method thereof |
| CN106075482A (en) * | 2016-08-16 | 2016-11-09 | 青岛云天生物技术有限公司 | A kind of medical ultrasonic coupling agent |
| CN106110342A (en) * | 2016-08-16 | 2016-11-16 | 青岛云天生物技术有限公司 | A kind of medical ultrasonic coupling agent and preparation method thereof |
| CN106139172A (en) * | 2016-08-16 | 2016-11-23 | 青岛云天生物技术有限公司 | A kind of bactericidal medical ultrasonic couplant and preparation method thereof |
| CN106139173A (en) * | 2016-08-16 | 2016-11-23 | 青岛云天生物技术有限公司 | A kind of ultrasonic coupling agent and preparation method thereof |
| CN106729775A (en) * | 2016-12-07 | 2017-05-31 | 唐山天恩科技有限公司 | Cavity sterile type medical ultrasonic coupling agent and preparation method thereof |
| CN107638573A (en) * | 2016-07-22 | 2018-01-30 | 上海宝阳医疗器械有限公司 | A kind of antibacterial medical ultrasound compounding agent and preparation method thereof |
| CN108042209A (en) * | 2017-12-20 | 2018-05-18 | 江苏省健尔康医用敷料有限公司 | Surgical operation towel |
| CN115475257A (en) * | 2022-08-29 | 2022-12-16 | 广州市一杰医药科技有限公司 | Medical ultrasonic coupling agent and preparation method thereof |
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| CN101648026A (en) * | 2009-07-21 | 2010-02-17 | 戴新春 | Sterilizing type medical ultrasonic coupling agent and preparation method thereof |
| CN102107013A (en) * | 2011-01-28 | 2011-06-29 | 武汉耦合医学科技有限责任公司 | Sterile ultrasound gel for invasive ultrasound diagnosis and treatment and preparation method thereof |
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2011
- 2011-12-31 CN CN2011104574764A patent/CN102512696A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101648026A (en) * | 2009-07-21 | 2010-02-17 | 戴新春 | Sterilizing type medical ultrasonic coupling agent and preparation method thereof |
| CN102107013A (en) * | 2011-01-28 | 2011-06-29 | 武汉耦合医学科技有限责任公司 | Sterile ultrasound gel for invasive ultrasound diagnosis and treatment and preparation method thereof |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194697A (en) * | 2015-11-05 | 2015-12-30 | 济宁博联生物科技有限公司 | Medical ultrasonic coupling agent and preparation method thereof |
| CN105194697B (en) * | 2015-11-05 | 2018-07-27 | 济宁博联生物科技有限公司 | A kind of medical ultrasonic coupling agent and preparation method thereof |
| CN107638573A (en) * | 2016-07-22 | 2018-01-30 | 上海宝阳医疗器械有限公司 | A kind of antibacterial medical ultrasound compounding agent and preparation method thereof |
| CN107638573B (en) * | 2016-07-22 | 2021-03-05 | 上海宝阳医疗器械有限公司 | Antibacterial medical ultrasonic coupling agent and preparation method thereof |
| CN106075483A (en) * | 2016-08-16 | 2016-11-09 | 青岛云天生物技术有限公司 | A kind of ultrasonic coupling agent for medical ultrasonic diagnosis and treatment and preparation method thereof |
| CN106075482A (en) * | 2016-08-16 | 2016-11-09 | 青岛云天生物技术有限公司 | A kind of medical ultrasonic coupling agent |
| CN106110342A (en) * | 2016-08-16 | 2016-11-16 | 青岛云天生物技术有限公司 | A kind of medical ultrasonic coupling agent and preparation method thereof |
| CN106139172A (en) * | 2016-08-16 | 2016-11-23 | 青岛云天生物技术有限公司 | A kind of bactericidal medical ultrasonic couplant and preparation method thereof |
| CN106139173A (en) * | 2016-08-16 | 2016-11-23 | 青岛云天生物技术有限公司 | A kind of ultrasonic coupling agent and preparation method thereof |
| CN106729775A (en) * | 2016-12-07 | 2017-05-31 | 唐山天恩科技有限公司 | Cavity sterile type medical ultrasonic coupling agent and preparation method thereof |
| CN108042209A (en) * | 2017-12-20 | 2018-05-18 | 江苏省健尔康医用敷料有限公司 | Surgical operation towel |
| CN115475257A (en) * | 2022-08-29 | 2022-12-16 | 广州市一杰医药科技有限公司 | Medical ultrasonic coupling agent and preparation method thereof |
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Application publication date: 20120627 |
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