CN106729775A - Cavity sterile type medical ultrasonic coupling agent and preparation method thereof - Google Patents
Cavity sterile type medical ultrasonic coupling agent and preparation method thereof Download PDFInfo
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- CN106729775A CN106729775A CN201611116964.8A CN201611116964A CN106729775A CN 106729775 A CN106729775 A CN 106729775A CN 201611116964 A CN201611116964 A CN 201611116964A CN 106729775 A CN106729775 A CN 106729775A
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- 239000007822 coupling agent Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 240000009138 Curcuma zedoaria Species 0.000 claims abstract description 16
- 239000008213 purified water Substances 0.000 claims abstract description 16
- 238000003756 stirring Methods 0.000 claims abstract description 16
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 15
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 15
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 15
- 229940046009 vitamin E Drugs 0.000 claims abstract description 15
- 239000011709 vitamin E Substances 0.000 claims abstract description 15
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000003392 Curcuma domestica Nutrition 0.000 claims abstract description 12
- 235000003405 Curcuma zedoaria Nutrition 0.000 claims abstract description 12
- 235000003373 curcuma longa Nutrition 0.000 claims abstract description 12
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 claims abstract description 12
- 235000013976 turmeric Nutrition 0.000 claims abstract description 12
- 235000019509 white turmeric Nutrition 0.000 claims abstract description 12
- 230000002421 anti-septic effect Effects 0.000 claims abstract description 9
- 230000001954 sterilising effect Effects 0.000 claims abstract description 8
- 239000000080 wetting agent Substances 0.000 claims abstract description 8
- 239000012467 final product Substances 0.000 claims abstract description 7
- 230000008961 swelling Effects 0.000 claims abstract description 7
- 244000008991 Curcuma longa Species 0.000 claims abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- GWEHVDNNLFDJLR-UHFFFAOYSA-N 1,3-diphenylurea Chemical compound C=1C=CC=CC=1NC(=O)NC1=CC=CC=C1 GWEHVDNNLFDJLR-UHFFFAOYSA-N 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical group CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- 229920002125 Sokalan® Polymers 0.000 claims description 6
- 229960001631 carbomer Drugs 0.000 claims description 6
- 229960003511 macrogol Drugs 0.000 claims description 6
- 238000012856 packing Methods 0.000 claims description 6
- 230000005855 radiation Effects 0.000 claims description 6
- 239000011265 semifinished product Substances 0.000 claims description 6
- 230000007306 turnover Effects 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 4
- 230000001575 pathological effect Effects 0.000 abstract description 5
- 230000029663 wound healing Effects 0.000 abstract description 4
- 206010011409 Cross infection Diseases 0.000 abstract description 3
- 206010029803 Nosocomial infection Diseases 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 244000163122 Curcuma domestica Species 0.000 description 8
- 239000000203 mixture Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000165940 Houjia Species 0.000 description 1
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241001502500 Trichomonadida Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acoustics & Sound (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of cavity sterile type medical ultrasonic coupling agent and preparation method thereof.Count by weight, including：0.5 2 parts of Kappa nurse；0.05 0.3 parts of vitamin E；3 parts of oil of zedoary turmeric；0.5 2.5 parts of antiseptic；1 3.5 parts of triethanolamine；10 22 parts of wetting agent；200 300 parts of purified water.Its preparation method：During Kappa nurse is uniformly dispersed in into antiseptic, wetting agent, it is subsequently adding in the purified water of 2/3 weight and stirs swelling, the purified water of remaining 1/3 weight is added and is well mixed, vitamin E, oil of zedoary turmeric are added and be well mixed, triethanolamine is added to stir, then embedding, 60Coradiation sterilizing, obtain final product.The present invention can meet antibacterial, aseptic and acoustic performance requirements, effectively prevent cross-infection complete, while having functions that nourishes rough skin, repairing pathological tissues, wound healing.
Description
Technical field
The present invention relates to medical detection reagent, specifically a kind of cavity sterile type medical ultrasonic coupling agent and its preparation side
Method.
Background technology
At present, existing cavity medical ultrasonic coupling agent only with the addition of antiseptic, only with part biocidal efficacies.Due to
Not sterile product, the patient to having pathological tissues or have the surface of a wound can introduce new flora, secondary injury is brought to patient.And it is same
When there is nourishes rough skin, repair pathological tissues, the cavity medical ultrasonic coupling agent of wound healing effect and there is no document report
Road.
The content of the invention
Present invention seek to address that the above mentioned problem that prior art is present, and providing one kind can meet antibacterial, aseptic and acoustics
Performance requirement, effectively prevent cross-infection complete, while having nourishes rough skin, repairing pathological tissues, wound healing effect
Cavity sterile type medical ultrasonic coupling agent and preparation method thereof.
The present invention solve its technical problem use technical scheme be：
A kind of cavity sterile type medical ultrasonic coupling agent, counts by weight, including：0.5-2 parts of Kappa nurse；Vitamin
E0.05-0.3 parts；3 parts of oil of zedoary turmeric；Antiseptic 0.5-2.5 parts；Triethanolamine 1-3.5 parts；Wetting agent 10-22 parts；Purified water
200-300 parts.
Preferably, described antiseptic is Bock-DP or the equal acardite of trichlorine.
Preferably, described wetting agent for propane diols, glycerine or Macrogol 600 one kind or combination.
The above-mentioned cavity preparation method of sterile type medical ultrasonic coupling agent, comprises the following steps：
（1）During Carbomer is uniformly dispersed in into wetting agent, antiseptic, 2/3 purified water is subsequently adding with 200-300rpm's
Speed is stirred 30 minutes, obtains mixed liquor within last naturally swelling 3 hours；
（2）By step（1）Gained mixed liquor is vacuumized, and vacuum is 0.08-0.10MPa, and rotating speed is 200-300rpm, Ran Houjia
Enter 1/3 purified water, stir 5 minutes, then deaerate 20 minutes；
（3）Oil of zedoary turmeric, vitamin E are added under these conditions, are stirred 10 minutes；
（4）Triethanolamine is added in above-mentioned mixed liquor under these conditions, is stirred 10 minutes, obtain final product cavity medical supersonic
Couplant；
（5）By step（4）Gained cavity is filling according to packing specification by bottle placer with medical ultrasonic coupling agent；
（6）By step（5）Gained semi-finished product are placed in Turnover Box, and finished product is after carrying out radiation sterilization.
Using the present invention of above-mentioned technical proposal, compared with prior art, its advantage is：
With the addition of oil of zedoary turmeric, vitamin E, oil of zedoary turmeric have the promoting flow of qi and blood circulation, remove necrosis and promote granulation, Xiao Ji Zhi Tong, promoting blood circulation and removing blood stasis, enhancing machine
The effect of body immunocompetence, and there is collaboration killing action to pathogenic microorganisms such as bacterium, mould, trichomonad, viruses, moreover it is possible to repair
Multiple pathological tissues and wound healing；Vitamin E has functions that nourishes rough skin；As sterile product, will not draw to patient
Enter new flora, while the Escherichia coli on carrier, staphylococcus aureus and Candida albicans can be killed, average killing rate
It is significantly more efficient to prevent cross-infection more than 99.9%, the safety and health of patient is ensured to greatest extent；Acoustic characteristic impedance is
1.55 × 106^Pa.s/m, the velocity of sound is 1540m/s, and acoustic attenuation coefficient slope is 0.003dB, and viscosity is 58.3Pa.s, meets coupling
The professional standard of mixture.
Specific embodiment
The present invention is described in detail in detail with reference to embodiments.
Embodiment 1：
A kind of cavity sterile type medical ultrasonic coupling agent, counts by weight, by 1 part of Kappa nurse, 0.1 part of vitamin E, curcuma zedoary
3 parts of oil, Bock-DP0.8 part, 1.5 parts of triethanolamine, 11.5 parts of glycerine, 3 parts of propane diols, 220 parts of purified water composition, it is made
Preparation Method is carried out as follows：
Step one, Carbomer is uniformly dispersed in glycerine, propane diols, Bock-DP, be subsequently adding 2/3 purified water with
The speed of 200-300rpm is stirred 30 minutes, obtains mixed liquor within last naturally swelling 3 hours；
Step 2, above-mentioned mixed liquor is vacuumized（Vacuum is 0.08MPa）, rotating speed is 200rpm, is subsequently adding 1/3 purifying
Water, stirs 5 minutes, then deaerate 20 minutes；
Step 3, the mixed liquor for adding oil of zedoary turmeric, vitamin E to stir under these conditions 10 minutes；
, be added to triethanolamine in above-mentioned mixed liquor under these conditions by step 4, stirs 10 minutes, obtains final product cavity with medical
Ultrasonic coupling agent；
Step 5, step 4 gained cavity is filling according to packing specification by bottle placer with medical ultrasonic coupling agent；
Step 6, step 5 gained semi-finished product are placed in Turnover Box, carry out radiation sterilization.
Embodiment 2：
A kind of cavity sterile type medical ultrasonic coupling agent, counts by weight, by 1 part of Kappa nurse, 0.1 part of vitamin E, curcuma zedoary
3 parts of oil, 1.8 parts of the equal acardite of trichlorine, 1.5 parts of triethanolamine, 8.5 parts of Macrogol 600,5 parts of propane diols, 220 parts of purified water
Composition, its preparation method is carried out as follows：
Step one, Carbomer is uniformly dispersed in the equal acardite of Macrogol 600, propane diols, trichlorine, is subsequently adding 2/3
Purified water stirred 30 minutes with the speed of 200-300rpm, obtain mixed liquor within last naturally swelling 3 hours；
Step 2, above-mentioned mixed liquor is vacuumized（Vacuum is 0.08MPa）, rotating speed is 200rpm, is subsequently adding 1/3 purifying
Water, stirs 5 minutes, then deaerate 20 minutes；
Step 3, the mixed liquor for adding oil of zedoary turmeric, vitamin E to stir under these conditions 10 minutes；
, be added to triethanolamine in above-mentioned mixed liquor under these conditions by step 4, stirs 10 minutes, obtains final product cavity with medical
Ultrasonic coupling agent；
Step 5, step 4 gained cavity is filling according to packing specification by bottle placer with medical ultrasonic coupling agent；
Step 6, step 5 gained semi-finished product are placed in Turnover Box, carry out radiation sterilization.
Embodiment 3：
A kind of cavity sterile type medical ultrasonic coupling agent, counts by weight, by 1 part of Kappa nurse, 0.1 part of vitamin E, curcuma zedoary
3 parts of oil, 2 parts of the equal acardite of trichlorine, 1.8 parts of triethanolamine, 6 parts of Macrogol 600,5 parts of glycerine, 230 parts of groups of purified water
Into its preparation method is carried out as follows：
Step one, Carbomer is uniformly dispersed in the equal acardite of Macrogol 600, glycerine, trichlorine, is subsequently adding 2/3
Purified water stirred 30 minutes with the speed of 200-300rpm, obtain mixed liquor within last naturally swelling 3 hours；
Step 2, above-mentioned mixed liquor is vacuumized（Vacuum is 0.08MPa）, rotating speed is 200rpm, is subsequently adding 1/3 purifying
Water, stirs 5 minutes, then deaerate 20 minutes；
Step 3, the mixed liquor for adding oil of zedoary turmeric, vitamin E to stir under these conditions 10 minutes；
, be added to triethanolamine in above-mentioned mixed liquor under these conditions by step 4, stirs 10 minutes, obtains final product cavity with medical
Ultrasonic coupling agent；
Step 5, step 4 gained cavity is filling according to packing specification by bottle placer with medical ultrasonic coupling agent；
Step 6, step 5 gained semi-finished product are placed in Turnover Box, carry out radiation sterilization.
Embodiment 4：
A kind of cavity sterile type medical ultrasonic coupling agent, counts by weight, by 1 part of Kappa nurse, 0.1 part of vitamin E, curcuma zedoary
Oil, 1.8 parts of the equal acardite of trichlorine, 1.8 parts of triethanolamine, 11.5 parts of glycerine, 3 parts of propane diols, 210 parts of compositions of purified water, its
Preparation method is carried out as follows：
Step one, Carbomer is uniformly dispersed in the equal acardite of glycerine, propane diols, trichlorine, is subsequently adding 2/3 purifying
Water is stirred 30 minutes with the speed of 200-300rpm, obtains mixed liquor within last naturally swelling 3 hours；
Step 2, above-mentioned mixed liquor is vacuumized（Vacuum is 0.08MPa）, rotating speed is 200rpm, is subsequently adding 1/3 purifying
Water, stirs 5 minutes, then deaerate 20 minutes；
Step 3, the mixed liquor for adding oil of zedoary turmeric, vitamin E to stir under these conditions 10 minutes；
, be added to triethanolamine in above-mentioned mixed liquor under these conditions by step 4, stirs 10 minutes, obtains final product cavity with medical
Ultrasonic coupling agent；
Step 5, step 4 gained cavity is filling according to packing specification by bottle placer with medical ultrasonic coupling agent；
Step 6, step 5 gained semi-finished product are placed in Turnover Box, carry out radiation sterilization.
Take above example 1-4 gained cavities carries out steriling test, sterilization with sterile type medical ultrasonic coupling agent in fact respectively
Test, acoustical behavior experiment meets the requirements.
Preferably feasible embodiment of the invention is the foregoing is only, not thereby limits to interest field of the invention,
The equivalence changes that all utilization description of the invention and content are made, are both contained within interest field of the invention.
Claims (4)
1. a kind of cavity sterile type medical ultrasonic coupling agent, it is characterised in that count by weight, including：Kappa nurse 0.5-2
Part；Vitamin E 0.05-0.3 parts；3 parts of oil of zedoary turmeric；Antiseptic 0.5-2.5 parts；Triethanolamine 1-3.5 parts；Wetting agent 10-22 parts；
Purified water 200-300 parts.
2. cavity according to claim 1 sterile type medical ultrasonic coupling agent, it is characterised in that：Described antiseptic is
Bock-DP or the equal acardite of trichlorine.
3. cavity according to claim 1 sterile type medical ultrasonic coupling agent, it is characterised in that：Described wetting agent is
Propane diols, glycerine, one kind of Macrogol 600 or combination.
4. a kind of preparation method of sterile type medical ultrasonic coupling agent of the cavity described in any one of claim 1-3, its feature
It is to comprise the following steps：
（1）During Carbomer is uniformly dispersed in into wetting agent, antiseptic, 2/3 purified water is subsequently adding with 200-300rpm's
Speed is stirred 30 minutes, obtains mixed liquor within last naturally swelling 3 hours；
（2）By step（1）Gained mixed liquor is vacuumized, and vacuum is 0.08-0.10MPa, is stirred under vacuum state, and rotating speed is
200-300rpm, is subsequently adding 1/3 purified water, stirs 5 minutes, then deaerate 20 minutes；
（3）Oil of zedoary turmeric, vitamin E are added under these conditions, are stirred 10 minutes；
（4）Triethanolamine is added in above-mentioned mixed liquor under these conditions, is stirred 10 minutes, obtain final product cavity medical supersonic
Couplant；
（5）By step（4）Gained cavity is filling according to packing specification by bottle placer with medical ultrasonic coupling agent；
（6）By step（5）Gained semi-finished product are placed in Turnover Box, and finished product is after carrying out radiation sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611116964.8A CN106729775A (en) | 2016-12-07 | 2016-12-07 | Cavity sterile type medical ultrasonic coupling agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611116964.8A CN106729775A (en) | 2016-12-07 | 2016-12-07 | Cavity sterile type medical ultrasonic coupling agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106729775A true CN106729775A (en) | 2017-05-31 |
Family
ID=58882110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611116964.8A Pending CN106729775A (en) | 2016-12-07 | 2016-12-07 | Cavity sterile type medical ultrasonic coupling agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106729775A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108514644A (en) * | 2018-04-10 | 2018-09-11 | 深圳市人民医院 | Magnetic resonance imaging contrast agent and preparation method thereof in short T2 effects rectum/vaginal canal |
| CN110559457A (en) * | 2019-09-05 | 2019-12-13 | 广州广工技术开发有限公司 | method for preparing medical ultrasonic coupling agent sterile product capable of being safely used |
| WO2020020114A1 (en) * | 2018-07-25 | 2020-01-30 | 苏州安德佳生物科技有限公司 | Biocompatible ultrasonic coupling agent for endoscope and use thereof |
| US11213615B2 (en) | 2017-02-28 | 2022-01-04 | EndoClot Plus Co.. Ltd | Composition for submucosal injection, reagent combination, and applications thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11213615B2 (en) | 2017-02-28 | 2022-01-04 | EndoClot Plus Co.. Ltd | Composition for submucosal injection, reagent combination, and applications thereof |
| CN108514644A (en) * | 2018-04-10 | 2018-09-11 | 深圳市人民医院 | Magnetic resonance imaging contrast agent and preparation method thereof in short T2 effects rectum/vaginal canal |
| CN108514644B (en) * | 2018-04-10 | 2021-07-20 | 深圳市人民医院 | Short T2 effect rectal/vaginal cavity internal magnetic resonance imaging contrast agent and preparation method thereof |
| WO2020020114A1 (en) * | 2018-07-25 | 2020-01-30 | 苏州安德佳生物科技有限公司 | Biocompatible ultrasonic coupling agent for endoscope and use thereof |
| CN110559457A (en) * | 2019-09-05 | 2019-12-13 | 广州广工技术开发有限公司 | method for preparing medical ultrasonic coupling agent sterile product capable of being safely used |
| CN110559457B (en) * | 2019-09-05 | 2020-06-12 | 广州广工技术开发有限公司 | Method for preparing medical ultrasonic coupling agent sterile product capable of being safely used |
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