CN104524600A - Medical sterilizing coupling agent and preparation method thereof - Google Patents
Medical sterilizing coupling agent and preparation method thereof Download PDFInfo
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- CN104524600A CN104524600A CN201410684452.6A CN201410684452A CN104524600A CN 104524600 A CN104524600 A CN 104524600A CN 201410684452 A CN201410684452 A CN 201410684452A CN 104524600 A CN104524600 A CN 104524600A
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- extracting solution
- pure water
- eucalyptus globolus
- medical disinfection
- carbomer
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Abstract
The invention discloses a medical sterilizing coupling agent including the following raw materials by mass: 0.35-0.5% of carbomer, 0.01-0.05% of cetyl pyridinium chloride, 0.5-1.5% of sodium hydroxide, 3-8% of propylene glycol, 0.5-4% of p-hydroxy-benzoate ester, 3-5% of eucalyptus extract and balance of pure water. The medical sterilizing coupling agent has the advantages that the appearance is pleasing to the eye, a user may not take unkindly to the medical sterilizing coupling agent, sterilization and disinfection are complete and safe, and the medical sterilizing coupling agent has no stimulation to skin.
Description
Technical field
The present invention relates to coupling agent for medical use, particularly relate to high medical disinfection couplant of a kind of safety and preparation method thereof.
Background technology
What ultrasonic examination was bound to use is exactly couplant, because when ultrasound wave incidence is swept on two kinds of different separating surfaces, the two impedance difference is larger, and emission ratio is larger, and the acoustic energy entering another medium through interface is fewer.For medical supersonic, if allow probe (or treatment head) and skin dry contact, due to the strong reflection effect of thin layer of air therebetween, send out ultrasound wave and cannot reach at all and enter human body, how to diagnose or therapeutical effect.For this reason, must by certain material filling and between detecting head surface and skin, to drive away air, form the passage making the smooth and easy and undistorted propagation of ultrasound wave.This material is exactly " medical ultrasonic coupling agent ", and the most preferred dosage form due to clinical high praise is gel, but in the practicality of reality, couplant also plays the effects such as lubricant, and what old friends were concerned about is not its acoustic characteristic.
A kind of excellent couplant should possess following condition: 1) good electrical insulating property harmony projectiveness; 2) well infiltrate with both detecting head surface and skin, with thorough deaeration; 3) long period and not mummification is kept after coating; 4), after coating, stickiness and adhesiveness is kept in a long time; 5) not chafe, does not produce anaphylaxis; 6) outward appearance is pleasing, patient can not be made to take exception, good water solubility, easy cleaning.
It is CN102178962A that State Intellectual Property Office discloses a publication number in No. 14, JIUYUE in 2011, name is called the patent of invention of " a kind of Medical disinfection/sterilization ultrasound couplant and preparation method thereof ", which disclosing its technical scheme is: a kind of Medical disinfection/sterilization ultrasound couplant, is prepared from by the raw material of following percentage by weight: Acritamer 940 0.2%-0.8%; Glycerol 3%-9%; Ethanol 2%-10%; Ethyl hydroxybenzoate 0.05%-0.4%; DPP-300 0.01%-0.04%; Chitosan 0.02%-0.06%; Sodium hydroxide 0.2%-1%; Distilled water surplus.Medical disinfection/sterilization ultrasound couplant of the present invention has the function of quick sterilization, and ethyl hydroxybenzoate, DPP and chitosan are sterilization bacteriostat.The disinfection component content comprised in this patent is low, and disinfection effect is good not, and in addition, the moistening effect of the ethanol of interpolation is bad, volatile.
Summary of the invention
The present invention is intended to solve in prior art, general couple agent outward appearance is not good, not easy cleaning and not good enough to skin moisture-keeping, the problem that the actual effect of disinfection is bad, propose one and comprise natural disinfection composition, disinfection effect is good, and it is pleasing to have outward appearance, the medical disinfection couplant of the advantage of good insulating, easy cleaning.
In order to realize foregoing invention object, technical scheme of the present invention is as follows: a kind of medical disinfection couplant, comprise the raw material of following mass percent: carbomer 0.35 ~ 0.5%, cetylpyridinium chloride 0.01 ~ 0.05%, sodium hydroxide 0.5 ~ 1.5%, propylene glycol 3 ~ 8%, p-Hydroxybenzoate 0.5 ~ 4%, eucalyptus globolus extracting solution 3 ~ 5%, surplus is pure water.
Described carbomer is preferably the one in the large Acritamer 940 of viscosity, Carbopol.
The concentration of described sodium hydroxide is 200PPM.
The concentration of described eucalyptus globolus extracting solution is 1.5 ~ 5%.
Described eucalyptus globolus extracting solution is the alcohol extract of eucalyptus globolus.
The preparation method of described medical disinfection couplant comprises the following steps:
(1) taking carbomer by formula is dissolved in appropriate pure water, soaks 1.5 days;
(2) taking cetylpyridinium chloride, propylene glycol, p-Hydroxybenzoate and sodium hydroxide by formula is dissolved in pure water, stirs 5 ~ 8min;
(3) added by the mixed liquor that step (2) obtains in step (1) in soaked carbomer, add the eucalyptus globolus extracting solution taken by formula, finally add the pure water amount of supplying, stir 10 ~ 12min, adjustment PH, to neutral, gets product.
Beneficial effect of the present invention:
The present invention is by the adjustment to each raw-material selection and ratio, make the outward appearance of products obtained therefrom pleasing, and long-time not mummification can be kept, also added plant extraction liquid natural constituent in addition, sterilizing is safer, reduce the use amount of chemosterilant, thus ensure that the safety of Rhizoma Nelumbinis connection agent, and the sterilization of plant extract can reduce the generation of resistance.
Detailed description of the invention
Embodiment 1
A kind of medical disinfection couplant, comprise the raw material of following mass percent: carbomer 0.35%, cetylpyridinium chloride 0.01%, sodium hydroxide 0.5%, propylene glycol 3%, p-Hydroxybenzoate 0.5%, eucalyptus globolus extracting solution 3%, surplus is pure water.
Embodiment 2
A kind of medical disinfection couplant, comprise the raw material of following mass percent: carbomer 0.5%, cetylpyridinium chloride 0.05%, sodium hydroxide 1.5%, propylene glycol 8%, p-Hydroxybenzoate 4%, eucalyptus globolus extracting solution 5%, surplus is pure water.
Embodiment 3
A kind of medical disinfection couplant, comprise the raw material of following mass percent: Acritamer 940 0.4%, cetylpyridinium chloride 0.03%, sodium hydroxide 1.1%, propylene glycol 5%, p-Hydroxybenzoate 1%, eucalyptus globolus extracting solution 4%, surplus is pure water.
In above-mentioned formula, the concentration of sodium hydroxide is 200PPM.
Embodiment 4
A kind of medical disinfection couplant, comprise the raw material of following mass percent: Acritamer 940 0.38%, cetylpyridinium chloride 0.02%, sodium hydroxide 1.3%, propylene glycol 6%, p-Hydroxybenzoate 2%, eucalyptus globolus extracting solution 3.5%, surplus is pure water.
In above-mentioned formula, the concentration of sodium hydroxide is 200PPM.
In above-mentioned formula, the concentration of eucalyptus globolus extracting solution is 1.5%
In above-mentioned formula, eucalyptus globolus extracting solution is the alcohol extract of eucalyptus globolus, its extracting method is: be after the ratio of 1:8 mixes with mass ratio by the eucalyptus globolus powder of drying and ethanol, three times are extracted with the carbon dioxide method for extracting of boundary over zero, and after being mixed by the extract of three times, being concentrated into concentration is 1.5%.
The preparation method of the medical disinfection couplant of the present embodiment comprises the following steps:
(1) taking carbomer by formula is dissolved in appropriate pure water, soaks 1.5 days;
(2) taking cetylpyridinium chloride, propylene glycol, p-Hydroxybenzoate and sodium hydroxide by formula is dissolved in pure water, stirs 5min;
(3) added by the mixed liquor that step (2) obtains in step (1) in soaked carbomer, add the eucalyptus globolus extracting solution taken by formula, finally add the pure water amount of supplying, stir 10min, regulate PH to neutral, get product eucalyptus globolus extracting solution.
Embodiment 5
A kind of medical disinfection couplant, comprise the raw material of following mass percent: Acritamer 940 0.4%, cetylpyridinium chloride 0.03%, sodium hydroxide 1.1%, propylene glycol 5%, p-Hydroxybenzoate 1%, eucalyptus globolus extracting solution 4%, surplus is pure water.
In above-mentioned formula, the concentration of sodium hydroxide is 200PPM.
In above-mentioned formula, the concentration of sodium hydroxide is 200PPM.
In above-mentioned formula, the concentration of eucalyptus globolus extracting solution is 5%
In above-mentioned formula, eucalyptus globolus extracting solution is the alcohol extract of eucalyptus globolus, its extracting method is: be after the ratio of 1:8 mixes with mass ratio by the eucalyptus globolus powder of drying and ethanol, three times are extracted with the carbon dioxide method for extracting of boundary over zero, and after being mixed by the extract of three times, being concentrated into concentration is 5%.
The preparation method of the medical disinfection couplant of the present embodiment comprises the following steps:
(1) taking carbomer by formula is dissolved in appropriate pure water, soaks 1.5 days;
(2) taking cetylpyridinium chloride, propylene glycol, p-Hydroxybenzoate and sodium hydroxide by formula is dissolved in pure water, stirs 8min;
(3) added by the mixed liquor that step (2) obtains in step (1) in soaked carbomer, add the eucalyptus globolus extracting solution taken by formula, finally add the pure water amount of supplying, stir 12min, regulate PH to neutral, get product eucalyptus globolus extracting solution.
Claims (6)
1. a medical disinfection couplant, its feature with the raw material comprising following mass percent: carbomer 0.35 ~ 0.5%, cetylpyridinium chloride 0.01 ~ 0.05%, sodium hydroxide 0.5 ~ 1.5%, propylene glycol 3 ~ 8%, p-Hydroxybenzoate 0.5 ~ 4%, eucalyptus globolus extracting solution 3 ~ 5%, surplus is pure water.
2. medical disinfection couplant as claimed in claim 1, is characterized in that: described carbomer is preferably the one in the large Acritamer 940 of viscosity, Carbopol.
3. medical disinfection couplant as claimed in claim 1 or 2, is characterized in that: the concentration of described sodium hydroxide is 200PPM.
4. medical disinfection couplant as claimed in claim 3, is characterized in that: the concentration of described eucalyptus globolus extracting solution is 1.5 ~ 5%.
5. medical disinfection couplant as claimed in claim 4, is characterized in that: described eucalyptus globolus extracting solution is the alcohol extract of eucalyptus globolus.
6. prepare a method for medical disinfection couplant as claimed in claim 1, it is characterized in that: comprise the following steps:
(1) taking carbomer by formula is dissolved in appropriate pure water, soaks 1.5 days;
(2) taking cetylpyridinium chloride, propylene glycol, p-Hydroxybenzoate and sodium hydroxide by formula is dissolved in pure water, stirs 5 ~ 8min;
(3) added by the mixed liquor that step (2) obtains in step (1) in soaked carbomer, add the eucalyptus globolus extracting solution taken by formula, finally add the pure water amount of supplying, stir 10 ~ 12min, regulate PH to neutral, get product eucalyptus globolus extracting solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410684452.6A CN104524600A (en) | 2014-11-25 | 2014-11-25 | Medical sterilizing coupling agent and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410684452.6A CN104524600A (en) | 2014-11-25 | 2014-11-25 | Medical sterilizing coupling agent and preparation method thereof |
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| CN104524600A true CN104524600A (en) | 2015-04-22 |
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| CN201410684452.6A Pending CN104524600A (en) | 2014-11-25 | 2014-11-25 | Medical sterilizing coupling agent and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106729775A (en) * | 2016-12-07 | 2017-05-31 | 唐山天恩科技有限公司 | Cavity sterile type medical ultrasonic coupling agent and preparation method thereof |
| CN112156382A (en) * | 2020-10-13 | 2021-01-01 | 青州市中医院 | Ultrasonic physiotherapy device for muscular dystrophy nursing based on oscillation circuit device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102580121A (en) * | 2012-03-06 | 2012-07-18 | 江苏壹叁玖医疗器械有限公司 | Medical disinfection coupling agent |
-
2014
- 2014-11-25 CN CN201410684452.6A patent/CN104524600A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102580121A (en) * | 2012-03-06 | 2012-07-18 | 江苏壹叁玖医疗器械有限公司 | Medical disinfection coupling agent |
Non-Patent Citations (1)
| Title |
|---|
| SUWEI ZHAO 等: "Supercritical CO2 extraction of Eucalyptus leaves oil and comparison with Soxhlet extraction and hydro-distillation methods", 《SEPARATION AND PURIFICATION TECHNOLOGY》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106729775A (en) * | 2016-12-07 | 2017-05-31 | 唐山天恩科技有限公司 | Cavity sterile type medical ultrasonic coupling agent and preparation method thereof |
| CN112156382A (en) * | 2020-10-13 | 2021-01-01 | 青州市中医院 | Ultrasonic physiotherapy device for muscular dystrophy nursing based on oscillation circuit device |
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Application publication date: 20150422 |
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