CN107753961A - A kind of Color Sonography ultrasonic coupling agent - Google Patents
A kind of Color Sonography ultrasonic coupling agent Download PDFInfo
- Publication number
- CN107753961A CN107753961A CN201711276162.8A CN201711276162A CN107753961A CN 107753961 A CN107753961 A CN 107753961A CN 201711276162 A CN201711276162 A CN 201711276162A CN 107753961 A CN107753961 A CN 107753961A
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- coupling agent
- ultrasonic coupling
- color sonography
- alginate
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- 239000007822 coupling agent Substances 0.000 title claims abstract description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 25
- 235000005340 Asparagus officinalis Nutrition 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 22
- 229920002101 Chitin Polymers 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 17
- 229960001631 carbomer Drugs 0.000 claims abstract description 17
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 14
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 14
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 13
- 229920000615 alginic acid Polymers 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims abstract description 12
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940072056 alginate Drugs 0.000 claims abstract description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 25
- 241000234427 Asparagus Species 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 10
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 9
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 6
- 239000000661 sodium alginate Substances 0.000 claims description 6
- 235000010413 sodium alginate Nutrition 0.000 claims description 6
- 229940005550 sodium alginate Drugs 0.000 claims description 6
- 241001116389 Aloe Species 0.000 claims description 5
- 235000011399 aloe vera Nutrition 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 239000003002 pH adjusting agent Substances 0.000 claims description 3
- 239000000737 potassium alginate Substances 0.000 claims description 3
- 235000010408 potassium alginate Nutrition 0.000 claims description 3
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 239000000783 alginic acid Substances 0.000 claims description 2
- 229960001126 alginic acid Drugs 0.000 claims description 2
- 150000004781 alginic acids Chemical class 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 239000004744 fabric Substances 0.000 claims description 2
- 238000000703 high-speed centrifugation Methods 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 239000006228 supernatant Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000523 sample Substances 0.000 abstract description 10
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 230000006378 damage Effects 0.000 abstract description 3
- 230000000845 anti-microbial effect Effects 0.000 abstract description 2
- 244000003416 Asparagus officinalis Species 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 9
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 206010011409 Cross infection Diseases 0.000 description 2
- 206010029803 Nosocomial infection Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
Abstract
The invention discloses a kind of Color Sonography ultrasonic coupling agent, include the raw material of following parts by weight：2~6 parts of asparagus juice, 1~3 part of chitin, 5~7 parts of carbomer, 2.5~3.5 parts of alginate, 2~4 parts of polyethylene glycol, 1.5~2.5 parts of alkyl-glucoside, 3~5 parts of ethanol, 100~150 parts of water.Couplant proposed by the present invention, raw material sources enrich, good antimicrobial effect, wetability and thixotropy be good, without greasy feeling, and couplant is easy in probe and skin surface expansion, desiccation phenomenon is not susceptible to after use, to skin and corrosion-free and damage of popping one's head in, pollution clothes are not easy, and be easy to clear up after, preparation method is simple, and production cost is low.
Description
Technical field
The present invention relates to couplant research and development technology field, more particularly to a kind of Color Sonography ultrasonic coupling agent.
Background technology
During ultrasonic examination, because the impedance difference between skin and probe is larger, cause reflectance factor larger, then add
The presence of air between upper skin and probe so that enter from the transmitted acoustic pulse that probe is sent through Air Interface in skin
Acoustic energy is greatly reduced, and both drives away air therefore, being often filled in using couplant between detecting head surface and skin, and can makes probe
It is easy to slide in skin surface, and the couplant filled can also form the distortionless propagation ducts of ultrasonic wave, slow down acoustic energy
Reduction, become apparent from image.Therefore it is wide in the application of medical domain, such as two-dimentional color ultrasound, three-dimensional color ultrasound, heart coloured silk
Superfine inspection needs to use couplant often.Couplant needs when in use and human contact, can be taken when contacting different people
With some germs, the cross-infection between examiner is caused, and operator and user easily pollute clothing when using couplant
Thing, the cleaning tape to clothing come difficult.In addition, existing couplant manufacturer is more, the couplant quality ginseng of production
Difference is uneven, price height.Cause the second-rate of the couplant of some manufacturers production, the skin of user can be made
Into stimulation, cause the allergic phenomenas such as red swelling of the skin；The wettability of some couplants is undesirable, and greasy feeling is strong, is not easy in skin
Deploy with detecting head surface；Some couplants for acid or alkalescence, for a long time using probe being caused to corrode and damaged, shorten
Service life of probe etc.；Easily there is the phenomenon of desiccation when in use in some couplants.In order to improve the property of couplant
Can, increasing researcher pays close attention to the research and development of couplant in recent years, such as Chinese patent application publication No.：CN107007848A is public
A kind of disinfection sterilizing type medical supersonic couplant is opened, but the bactericide used in the raw material of the ultrasonic coupling agent needs to carry out spy
Different to prepare, the use to bactericide adds difficulty, and other accessory substances can be produced in course of reaction, it is also necessary to is purified
Deng operation so that the utilization rate of raw material is generally relatively low.Based on above-mentioned the deficiencies in the prior art, the present invention proposes one kind
The Color Sonography ultrasonic coupling agent that raw material sources are abundant, bactericidal effect is good.
The content of the invention
The invention aims to solve the shortcomings that bactericidal effect present in prior art is poor, raw material sources are rare,
A kind of and Color Sonography ultrasonic coupling agent proposed.
A kind of Color Sonography ultrasonic coupling agent, include the raw material of following parts by weight：Include the raw material of following parts by weight：Aloe
2~6 parts of juice, 1~3 part of chitin, 5~7 parts of carbomer, 2.5~3.5 parts of alginate, 2~4 parts of polyethylene glycol, alkyl grape
1.5~2.5 parts of glucosides, 3~5 parts of ethanol, 100~150 parts of water.
Preferably, the ultrasonic coupling agent includes the raw material of following parts by weight：4 parts of asparagus juice, 2 parts of chitin, carbomer 6
Part, 3 parts of alginate, 3 parts of polyethylene glycol, 2 parts of alkyl-glucoside, 4 parts of ethanol, 130 parts of water.
Preferably, the mass ratio of the asparagus juice and chitin is 1~3：1.
Preferably, the mass ratio of the carbomer and alginate is 2：1, and alginate is sodium alginate, alginic acid
Any one in potassium.
Preferably, the preparation process of the asparagus juice comprises the following steps：Fresh aloe is cleaned up, ultraviolet disinfection kills
Bacterium, remove the peel again, be subsequently placed in pulverizer and crush, reuse 100 eye mesh screens and filtered, until aloe is all by screen cloth,
High speed centrifugation is carried out again, and it is asparagus juice to collect and merge supernatant.
Preferably, the preparation method of the Color Sonography ultrasonic coupling agent comprises the following steps：
S1, the polyethylene glycol of corresponding parts by weight is dissolved in the water of 20~30 times of mass parts, is well mixed, obtains mixed liquor
A；
S2, the asparagus juice of corresponding parts by weight, chitin, alkyl-glucoside and ethanol is added in the water of surplus, mixed
Close uniformly, obtain mixed liquid B；
S3, mixed liquor A and mixed liquid B mixed, and add the carbomer and alginate of corresponding parts by weight, stirring 10~
30min, mixture C is obtained, then then the pH value for adjusting mixture C with pH adjusting agent is transferred in homogenizer to 6.5~7.5
Homogeneous is carried out, produces Color Sonography ultrasonic coupling agent.
Preferably, the pH adjusting agent is sodium hydroxide in the aqueous solution of sodium hydroxide or, the sodium hydrate aqueous solution
Mass concentration be 3%~5%.
Preferably, the pressure of the homogeneous is 10~40MPa, and the temperature of homogeneous is 4~30 DEG C.
Couplant proposed by the present invention, raw material sources enrich, good antimicrobial effect, wetability and thixotropy it is good, without greasy feeling,
To skin and corrosion-free and damage of popping one's head in, pollution clothes are not easy, and are easy to clear up after, preparation method is simple, production cost
It is low；With carbomer and alginate collectively as the main component of couplant, the usage amount of carbomer is reduced, and then reduce production
Cost, add in the feed rational proportion asparagus juice and chitin to play excellent antibacterial effect, during avoiding use
Cross-infection, then coordinate the addition of polyethylene glycol, alkyl-glucoside and ethanol, the wetability of couplant can be improved and touched
Denaturation, couplant is set to be easy to, in probe and skin surface expansion, desiccation phenomenon, and the composition in raw material are not susceptible to after use
Solute effect in water is good, is not easy pollution clothes when in use, is readily cleaned after use, is not easy to be adhered to skin and probe table
Face, and then reduce the injury to skin and probe, along with preparation process to the reasonable adjusting of couplant pH value, further
Ensure the security that couplant uses, and the invention also provides a kind of simple to operate, production cost it is low prepare couplant
Method, and in the couplant prepared each raw material good mixing effect, performance is homogeneous, stably.
Embodiment
The present invention is made with reference to specific embodiment further to explain.
Embodiment one
A kind of Color Sonography ultrasonic coupling agent proposed by the present invention, include the raw material of following parts by weight：Including following weight
The raw material of part：4 parts of asparagus juice, 2 parts of chitin, 6 parts of carbomer, 3 parts of sodium alginate, 3 parts of polyethylene glycol, alkyl-glucoside 2
Part, 4 parts of ethanol, 130 parts of water；
Its preparation method comprises the following steps：
S1, the polyethylene glycol of corresponding parts by weight is dissolved in the water of 25 times of mass parts, is well mixed, obtains mixed liquor A；
S2, the asparagus juice of corresponding parts by weight, chitin, alkyl-glucoside and ethanol is added in the water of surplus, mixed
Close uniformly, obtain mixed liquid B；
S3, mixed liquor A and mixed liquid B mixed, and add the carbomer and sodium alginate of corresponding parts by weight, stirred
20min, obtains mixture C, then adjusts the pH value of mixture C to 6.5~7.5 with the sodium hydroxide solution that mass concentration is 4%, so
After transfer in homogenizer, and pressure in 20MPa, carry out homogeneous at a temperature of 20 DEG C, produce Color Sonography ultrasonic coupling
Agent.
Embodiment two
A kind of Color Sonography ultrasonic coupling agent proposed by the present invention, include the raw material of following parts by weight：Including following weight
The raw material of part：2 parts of asparagus juice, 1 part of chitin, 6 parts of carbomer, 3 parts of potassium alginate, 4 parts of polyethylene glycol, alkyl-glucoside 2
Part, 3 parts of ethanol, 120 parts of water；
Its preparation method comprises the following steps：
S1, the polyethylene glycol of corresponding parts by weight is dissolved in the water of 20 times of mass parts, is well mixed, obtains mixed liquor A；
S2, the asparagus juice of corresponding parts by weight, chitin, alkyl-glucoside and ethanol is added in the water of surplus, mixed
Close uniformly, obtain mixed liquid B；
S3, mixed liquor A and mixed liquid B mixed, and add the carbomer and potassium alginate of corresponding parts by weight, stirred
30min, obtains mixture C, then adjusts the pH value of mixture C to 6.5~7.5 with the sodium hydroxide solution that mass concentration is 3%, so
After transfer in homogenizer, and pressure in 10MPa, carry out homogeneous at a temperature of 10 DEG C, produce Color Sonography ultrasonic coupling
Agent.
Embodiment three
A kind of Color Sonography ultrasonic coupling agent proposed by the present invention, include the raw material of following parts by weight：Including following weight
The raw material of part：6 parts of asparagus juice, 2 parts of chitin, 7 parts of carbomer, 3.5 parts of sodium alginate, 2 parts of polyethylene glycol, alkyl-glucoside
1.5 parts, 4 parts of ethanol, 150 parts of water；
Its preparation method comprises the following steps：
S1, the polyethylene glycol of corresponding parts by weight is dissolved in the water of 30 times of mass parts, is well mixed, obtains mixed liquor A；
S2, the asparagus juice of corresponding parts by weight, chitin, alkyl-glucoside and ethanol is added in the water of surplus, mixed
Close uniformly, obtain mixed liquid B；
S3, mixed liquor A and mixed liquid B mixed, and add the carbomer and sodium alginate of corresponding parts by weight, stirred
10min, obtains mixture C, then adjusts the pH value of mixture C to 6.5~7.5 with the sodium hydroxide solution that mass concentration is 5%, so
After transfer in homogenizer, and pressure in 40MPa, carry out homogeneous at a temperature of 4 DEG C, produce Color Sonography ultrasonic coupling
Agent.
Comparative example one
Asparagus juice in embodiment one and chitin are removed, other conditions are constant, and couplant is made.
Comparative example two
Chitin in the raw material of couplant in embodiment one is removed, other conditions are constant, and couplant is made.
Comparative example three
Asparagus juice in the raw material of couplant in embodiment one is removed, other conditions are constant, and couplant is made.
To the coupling prepared in embodiment one, embodiment two, embodiment three and comparative example one, comparative example two and comparative example three
Mixture is detected respectively, and testing result is as follows：
The velocity of sound, acoustic characteristic impedance and acoustic attenuation coefficient slope result are shown：Embodiment one, embodiment two and embodiment three
Testing result is better than comparative example one, comparative example two and comparative example three, shows：Coupling agent prescription proposed by the present invention and preparation
The stable performance of couplant prepared by method, the velocity of sound is fast, acoustic characteristic impedance is low, acoustic attenuation slope coefficient is low.
The testing result of sterilizing rate is shown：Couplant prepared by embodiment one, embodiment two and embodiment three is to large intestine bar
Bacterium, staphylococcus aureus and Candida albicans are respectively provided with 99% and above killing rate, and are added without asparagus juice and chitin, or
A kind of killing rate to Escherichia coli, staphylococcus aureus and Candida albicans that person is only added in asparagus juice and chitin is all
It can be decreased obviously, show：Asparagus juice and chitin have the effect of Synergistic biocidal, and bactericidal effect is excellent.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (8)
1. a kind of Color Sonography ultrasonic coupling agent, it is characterised in that include the raw material of following parts by weight：2~6 parts of asparagus juice, first
1~3 part of shell element, 5~7 parts of carbomer, 2.5~3.5 parts of alginate, 2~4 parts of polyethylene glycol, alkyl-glucoside 1.5~
2.5 parts, 3~5 parts of ethanol, 100~150 parts of water.
2. a kind of Color Sonography ultrasonic coupling agent according to claim 1, it is characterised in that the ultrasonic coupling agent includes
The raw material of following parts by weight：4 parts of asparagus juice, 2 parts of chitin, 6 parts of carbomer, 3 parts of alginate, 3 parts of polyethylene glycol, alkyl Portugal
2 parts of polyglycoside, 4 parts of ethanol, 130 parts of water.
3. a kind of Color Sonography ultrasonic coupling agent according to claim 1, it is characterised in that the asparagus juice and chitin
Mass ratio be 1~3：1.
4. a kind of Color Sonography ultrasonic coupling agent according to claim 1, it is characterised in that the carbomer and alginic acid
The mass ratio of salt is 2：1, and alginate is any one in sodium alginate, potassium alginate.
A kind of 5. Color Sonography ultrasonic coupling agent according to claim 1, it is characterised in that the preparation of the asparagus juice
Journey comprises the following steps：Fresh aloe is cleaned up, ultraviolet disinfection sterilization, remove the peel again, be subsequently placed in pulverizer and crush, then
Filtered using 100 eye mesh screens, until aloe is all by screen cloth, then carries out high speed centrifugation, collect and merge supernatant i.e.
For asparagus juice.
6. a kind of Color Sonography ultrasonic coupling agent according to claim 1 or 2 or 3 or 4 or 5, it is characterised in that it is prepared
Method comprises the following steps：
S1, the polyethylene glycol of corresponding parts by weight is dissolved in the water of 20~30 times of mass parts, is well mixed, obtains mixed liquor A；
S2, the asparagus juice of corresponding parts by weight, chitin, alkyl-glucoside and ethanol is added in the water of surplus, mixing is equal
It is even, obtain mixed liquid B；
S3, mixed liquor A and mixed liquid B mixed, and add the carbomer and alginate of corresponding parts by weight, stirring 10~
30min, mixture C is obtained, then then the pH value for adjusting mixture C with pH adjusting agent is transferred in homogenizer to 6.5~7.5
Homogeneous is carried out, produces Color Sonography ultrasonic coupling agent.
7. the preparation method of a kind of Color Sonography ultrasonic coupling agent according to claim 6, it is characterised in that the pH is adjusted
The mass concentration for saving sodium hydroxide in the aqueous solution or, the sodium hydrate aqueous solution that agent is sodium hydroxide is 3%~5%.
A kind of 8. preparation method of Color Sonography ultrasonic coupling agent according to claim 6, it is characterised in that the homogeneous
Pressure be 10~40MPa, the temperature of homogeneous is 4~30 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711276162.8A CN107753961B (en) | 2017-12-06 | 2017-12-06 | Heart color ultrasound coupling agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711276162.8A CN107753961B (en) | 2017-12-06 | 2017-12-06 | Heart color ultrasound coupling agent |
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| Publication Number | Publication Date |
|---|---|
| CN107753961A true CN107753961A (en) | 2018-03-06 |
| CN107753961B CN107753961B (en) | 2020-09-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711276162.8A Active CN107753961B (en) | 2017-12-06 | 2017-12-06 | Heart color ultrasound coupling agent |
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| Country | Link |
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| CN (1) | CN107753961B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010851A (en) * | 2018-08-24 | 2018-12-18 | 广州恒腾电子科技有限公司 | A kind of couplant for ultrasound detection |
| CN109529062A (en) * | 2019-01-18 | 2019-03-29 | 高文娟 | A kind of Ultrasonography novel couplant |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711879A (en) * | 2009-11-21 | 2010-05-26 | 日照众生医疗科技有限公司 | Sterilizing medical ultrasonic coupling agent and preparation method thereof |
| CN106075483A (en) * | 2016-08-16 | 2016-11-09 | 青岛云天生物技术有限公司 | A kind of ultrasonic coupling agent for medical ultrasonic diagnosis and treatment and preparation method thereof |
| CN107158414A (en) * | 2017-06-22 | 2017-09-15 | 江苏依柯化工有限公司 | A kind of antibacterial skin-moisturizing medical ultrasonic coupling agent of disinfection and preparation method thereof |
-
2017
- 2017-12-06 CN CN201711276162.8A patent/CN107753961B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711879A (en) * | 2009-11-21 | 2010-05-26 | 日照众生医疗科技有限公司 | Sterilizing medical ultrasonic coupling agent and preparation method thereof |
| CN106075483A (en) * | 2016-08-16 | 2016-11-09 | 青岛云天生物技术有限公司 | A kind of ultrasonic coupling agent for medical ultrasonic diagnosis and treatment and preparation method thereof |
| CN107158414A (en) * | 2017-06-22 | 2017-09-15 | 江苏依柯化工有限公司 | A kind of antibacterial skin-moisturizing medical ultrasonic coupling agent of disinfection and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| M.S. BENHABILES ET AL.: "Antibacterial activity of chitin, chitosan and its oligomers prepared from shrimp shell waste", 《FOOD HYDROCOLLOIDS》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010851A (en) * | 2018-08-24 | 2018-12-18 | 广州恒腾电子科技有限公司 | A kind of couplant for ultrasound detection |
| CN109529062A (en) * | 2019-01-18 | 2019-03-29 | 高文娟 | A kind of Ultrasonography novel couplant |
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| Publication number | Publication date |
|---|---|
| CN107753961B (en) | 2020-09-11 |
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