CN109010851A - A kind of couplant for ultrasound detection - Google Patents
A kind of couplant for ultrasound detection Download PDFInfo
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- CN109010851A CN109010851A CN201810973821.1A CN201810973821A CN109010851A CN 109010851 A CN109010851 A CN 109010851A CN 201810973821 A CN201810973821 A CN 201810973821A CN 109010851 A CN109010851 A CN 109010851A
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- parts
- extract
- couplant
- ultrasound detection
- sodium
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- 238000001514 detection method Methods 0.000 title claims abstract description 27
- 238000002604 ultrasonography Methods 0.000 title claims abstract description 26
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 66
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 60
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims abstract description 45
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000000284 extract Substances 0.000 claims abstract description 40
- 229940069521 aloe extract Drugs 0.000 claims abstract description 31
- 241000605447 Anemarrhena Species 0.000 claims abstract description 29
- 229930191283 anemarrhena Natural products 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000002994 raw material Substances 0.000 claims abstract description 23
- 229940051250 hexylene glycol Drugs 0.000 claims abstract description 22
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 21
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 21
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 21
- 239000011790 ferrous sulphate Substances 0.000 claims abstract description 19
- 235000003891 ferrous sulphate Nutrition 0.000 claims abstract description 19
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims abstract description 19
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims abstract description 19
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 18
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 18
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 18
- 239000000661 sodium alginate Substances 0.000 claims abstract description 18
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 18
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 18
- 150000001875 compounds Chemical class 0.000 claims abstract description 13
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 12
- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 12
- 239000000706 filtrate Substances 0.000 claims description 22
- 238000002360 preparation method Methods 0.000 claims description 22
- 238000001914 filtration Methods 0.000 claims description 14
- 239000007822 coupling agent Substances 0.000 claims description 12
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical group CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- -1 aloe extract Substances 0.000 claims description 7
- 229960005150 glycerol Drugs 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 229940083608 sodium hydroxide Drugs 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 claims description 6
- 238000004321 preservation Methods 0.000 claims description 6
- 241001116389 Aloe Species 0.000 claims description 5
- 235000011399 aloe vera Nutrition 0.000 claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 238000005119 centrifugation Methods 0.000 claims description 4
- 229960004756 ethanol Drugs 0.000 claims description 4
- 235000019441 ethanol Nutrition 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 241000605445 Anemarrhena asphodeloides Species 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 238000005341 cation exchange Methods 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims description 2
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 230000001376 precipitating effect Effects 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 3
- 150000001336 alkenes Chemical class 0.000 claims 3
- 238000004132 cross linking Methods 0.000 claims 3
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 3
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000013049 sediment Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 13
- 230000001954 sterilising effect Effects 0.000 abstract description 10
- 231100000252 nontoxic Toxicity 0.000 abstract description 3
- 230000003000 nontoxic effect Effects 0.000 abstract description 3
- 238000009472 formulation Methods 0.000 abstract description 2
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 24
- 230000000694 effects Effects 0.000 description 9
- 238000011017 operating method Methods 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 235000010443 alginic acid Nutrition 0.000 description 4
- 229960001126 alginic acid Drugs 0.000 description 4
- 239000000783 alginic acid Substances 0.000 description 4
- 229920000615 alginic acid Polymers 0.000 description 4
- 150000004781 alginic acids Chemical class 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 3
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 3
- 239000011630 iodine Substances 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000005864 Sulphur Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 229940098465 tincture Drugs 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 241001484259 Lacuna Species 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 229960002358 iodine Drugs 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000007686 potassium Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Abstract
The invention discloses a kind of couplants for ultrasound detection, are prepared comprising following raw material: 18 ~ 37 parts of polyacrylic acid crosslinked compound, 8 ~ 12 parts of aloe extract, 10 ~ 15 parts of anemarrhena asphodefoides extract, 7 ~ 9 parts of sodium alginate, 120 ~ 170 parts of glycerol, 3 ~ 12 parts of sodium hydroxide, 10 ~ 20 parts of hexylene glycol, 3 ~ 7.5 parts of potassium iodide, 0.5 ~ 4.5 part of ferrous sulfate, 10 ~ 25 parts of hydroxyethyl cellulose, 3 ~ 8 parts of sodium benzoate, 650 ~ 950 parts of water.Couplant of the present invention for ultrasound detection, not only there is extremely strong sterilizing ability, nontoxic to human skin, non-stimulated, compared with prior art, is also significantly reduced acoustic attenuation coefficient, is more conducive to ultrasonic Clinics and Practices medically.In addition, inventive formulation is relatively simple, raw material is easy to get, easy to operate, cost-saved, is suitble to large-scale production.
Description
Technical field
The couplant and preparation method thereof that the present invention relates to a kind of for ultrasound detection.
Background technique
When ultrasonic wave is mapped on the interface of two kinds of different mediums, reflection can be generated, ultrasonic wave is caused to enter another matchmaker
The acoustic wave energy of matter can be fewer.And ultrasonic wave is then related to some index of two kinds of mediums by degree of reflection, this index is exactly
Acoustic impedance, acoustic impedance indicate that certain medium propagates ultrasonic wave the ability hindered.Certainly, different mediums has different acoustic resistances
It is anti-, for physics angle, when the acoustic impedance difference of two kinds of mediums is bigger, then reflect more.Therefore, in ultrasonic examination,
If ultrasonic probe is allowed directly to contact with measured object, the lacuna full of air is certainly existed therebetween, is equivalent in ultrasound
An interface is formed between probe and air, since there are biggish acoustic impedance differences, when the ultrasonic wave that ultrasonic probe is launched is advanced
When to Air Interface, strong reflex can be generated, causes conventional detection that can not complete.
With both at home and abroad to the health of clinical examination and cross-infection problem growing interest and attention, to it is extraordinary (it is sterile,
Sterilization etc.) demand of medical ultrasonic coupling agent also gradually increases.For example Her Majesty the Queen in right of Canada as represented by the minister of Healt's door is just distinctly claimed: " for device
Part passes through all invasive operations of tissue (such as positioning and organize biopsy with needle suction, with needle), is related to gnotobasis and non-
Intact skin, baby monitor room baby with carry out all operations, it is necessary to use sterile type couplant.
For having the inspection or operation of wound property, domestic majority sonographer or clinician use sterile physiological more
Salt water or the disinfection tincture of iodine are able to satisfy clinical needs substantially, but since sterile saline or the disinfection tincture of iodine are easy dry steam
Hair, poor adhesion, need constantly to fill, compare time and effort consuming.
Therefore, a kind of ultrasonic coupling agent is needed at us, it is desirable that it is approximately equal with measured object acoustic impedance, to reduce reflection damage
It loses；Sterilizing ability is strong；Acoustic attenuation coefficient wants small, reduces the attenuation losses of ultrasonic wave to the greatest extent.The present invention comes therefrom.
Summary of the invention
Technical problem to be solved by the present invention lies in provide that a kind of sterilizing ability is strong, acoustic attenuation coefficient is small is used for
Couplant of ultrasound detection and preparation method thereof.
A kind of present invention couplant and preparation method thereof for ultrasound detection to be provided, by following technical solution
It is achieved:
A kind of couplant for ultrasound detection, is prepared by the raw material comprising following parts by weight: polyacrylic acid crosslinked chemical combination
18 ~ 37 parts of object, 10 ~ 15 parts of anemarrhena asphodefoides extract, 8 ~ 12 parts of aloe extract, 7 ~ 9 parts of sodium alginate, 120 ~ 170 parts of glycerol,
3 ~ 12 parts of sodium hydroxide, 10 ~ 20 parts of hexylene glycol, 3 ~ 7.5 parts of potassium iodide, 0.5 ~ 4.5 part of ferrous sulfate, hydroxyethyl cellulose 10 ~
25 parts, 3 ~ 8 parts of sodium benzoate, 650 ~ 950 parts of water.
As a preferred embodiment, the couplant for ultrasound detection, by the raw material system comprising following parts by weight
It is standby to obtain: 25 ~ 30 parts of polyacrylic acid crosslinked compound, 12 ~ 13 parts of anemarrhena asphodefoides extract, 9 ~ 10 parts of aloe extract, alginic acid
7.5 ~ 8.5 parts of sodium, 140 ~ 150 parts of glycerol, 6 ~ 9 parts of sodium hydroxide, 14 ~ 16 parts of hexylene glycol, 4 ~ 6.5 parts of potassium iodide, sulfuric acid
Ferrous 1.5 ~ 3.5 parts, 15 ~ 20 parts of hydroxyethyl cellulose, 4 ~ 6 parts of sodium benzoate, 750 ~ 850 parts of water.
As a kind of optimal case, the couplant for ultrasound detection, by the raw material system comprising following parts by weight
It is standby to obtain: 28 parts of polyacrylic acid crosslinked compound, 12.5 parts of anemarrhena asphodefoides extract, 10 parts of aloe extract, 8 parts of sodium alginate,
145 parts of glycerol, 8 parts of sodium hydroxide, 15 parts of hexylene glycol, 5.5 parts of potassium iodide, 2 parts of ferrous sulfate, hydroxyethyl cellulose 18
Part, 4.5 parts of sodium benzoate, 800 parts of water.
As a preferred embodiment, the polyacrylic acid crosslinked compound is CARBOPOL 974P.
As a preferred embodiment, the preparation method of the aloe extract, comprises the following steps:
S21. by aloe powder, by solid-to-liquid ratio 1(kg): 4 ~ 6(L) hydrochloric acid solution that concentration is 0.5 ~ 0.6mol/L is added, it is put into 70-
In 80 DEG C of water-baths, is filtered after 2 ~ 3h, obtain filtrate；
S22. the filtrate PH in step S1. is adjusted to 7.0, then presses filtrate: 95% ethyl alcohol weight ratio of volume fraction is 1: 6-8, by volume
The ethyl alcohol of score 95% is added in filtrate, stands precipitating completely；
S23. it being centrifuged, 5000 ~ 7000r/min of revolving speed, then time 20-25min is successively washed with ether, dehydrated alcohol,
Pellet frozen is dry, obtains aloe extract；
As a preferred embodiment, the anemarrhena asphodefoides extract the preparation method comprises the following steps:
S31. Common Anemarrhena Rhizome is taken, by solid-to-liquid ratio 1(kg): 30 ~ 60(L) distilled water is added, 1-2 h is extracted at 90-100 DEG C；
S32. it is centrifuged, centrifugation time 4000-5000r/min, 10 ~ 25min of centrifugation time, centrifugate leads to liquid in 30-40ml's
Strongly acidic cation-exchange adjusts pH to 6-6.5, and after being concentrated under reduced pressure at 40 ~ 45 DEG C, rhizoma anemarrhenae is obtained after freeze-drying
Extract.
As a preferred embodiment, the preparation method of the couplant for ultrasound detection, which is characterized in that comprising such as
Lower step:
S11. by CARBOPOL 974P, anemarrhena asphodefoides extract, aloe extract, sodium alginate, glycerol, sodium hydroxide, hexylene glycol, iodine
Change potassium, ferrous sulfate, hydroxyethyl cellulose, sodium benzoate, water to sequentially add mixing and reacted, after heating, keep the temperature, filtering,
Obtain filtrate；
S12. the filtrate being obtained by filtration in S1. is ultrasonically treated, obtains ultrasonic coupling agent.
As a preferred embodiment, heating temperature described in S1. is 45 ~ 55 DEG C, and soaking time is 10 ~ 20min.
As a preferred embodiment, supersonic frequency described in S1. is 15 ~ 20kHz, and ultrasonic time is 15 ~ 20min.
The utility model has the advantages that the couplant of the present invention for ultrasound detection, aloe extract and rhizoma anemarrhenae are contained in raw material
Extract, two kinds of extracts can enhance the sterilizing power of thimerosal, the weak coefficient of reduction sound, the group of two kinds of extracts
The effect that effect is much better than any single extract is closed, there is synergistic function, not only have extremely strong sterilizing ability, to human body
Skin is nontoxic, non-stimulated, is also significantly reduced acoustic attenuation coefficient, is more conducive to ultrasonic Clinics and Practices medically.In addition,
Inventive formulation is relatively simple, and raw material is easy to get, easy to operate, cost-saved.
Specific embodiment
It is explained further the present invention with reference to embodiments, but embodiment do not do any form to the present invention and limit.
A kind of couplant for ultrasound detection of embodiment 1
Composition of raw materials: 28 parts of polyacrylic acid crosslinked compound, 12.5 parts of anemarrhena asphodefoides extract, 10 parts of aloe extract, alginic acid
8 parts of sodium, 145 parts of glycerol, 8 parts of sodium hydroxide, 15 parts of hexylene glycol, 5.5 parts of potassium iodide, 2 parts of ferrous sulfate, ethoxy are fine
Tie up plain 18 parts, 4.5 parts of sodium benzoate, 800 parts of water.
Preparation method:
S1. by CARBOPOL 974P, anemarrhena asphodefoides extract, aloe extract, sodium alginate, glycerol, sodium hydroxide, hexylene glycol, iodate
Potassium, ferrous sulfate, hydroxyethyl cellulose, sodium benzoate, water sequentially add mixing and are reacted, and are heated to 50 DEG C, heat preservation 18
After min, filtering, filtrate is obtained；
S2. the filtrate being obtained by filtration in S1. is ultrasonically treated, supersonic frequency 18kHz, ultrasonic time 17min is obtained
Ultrasonic coupling agent.
A kind of couplant for ultrasound detection of embodiment 2
Composition of raw materials: 18 parts of CARBOPOL 974P, 7 parts of sodium alginate, 10 parts of anemarrhena asphodefoides extract, 8 parts of aloe extract, glycerol
120 parts, 3 parts of sodium hydroxide, 10 parts of hexylene glycol, 3 parts of potassium iodide, 0.5 part of ferrous sulfate, 10 parts of hydroxyethyl cellulose, benzoic acid
3 parts of sodium, 650 parts of water.
Preparation method:
S1. by CARBOPOL 974P, anemarrhena asphodefoides extract, aloe extract, sodium alginate, glycerol, sodium hydroxide, hexylene glycol, iodate
Potassium, ferrous sulfate, hydroxyethyl cellulose, sodium benzoate, water sequentially add mixing and are reacted, and are heated to 50 DEG C, heat preservation 18
After min, filtering, filtrate is obtained；
S2. the filtrate being obtained by filtration in S1. is ultrasonically treated, supersonic frequency 18kHz, ultrasonic time 17min is obtained
Ultrasonic coupling agent.
A kind of couplant for ultrasound detection of embodiment 3
Composition of raw materials: 37 parts of CARBOPOL 974P, 9 parts of sodium alginate, 15 parts of anemarrhena asphodefoides extract, 12 parts of aloe extract, glycerol
170 parts, 12 parts of sodium hydroxide, 20 parts of hexylene glycol, 7.5 parts of potassium iodide, 4.5 parts of ferrous sulfate, hydroxyethyl cellulose 25
Part, 8 parts of sodium benzoate, 950 parts of water.
Preparation method:
S1. by CARBOPOL 974P, anemarrhena asphodefoides extract, aloe extract, sodium alginate, glycerol, sodium hydroxide, hexylene glycol, iodate
Potassium, ferrous sulfate, hydroxyethyl cellulose, sodium benzoate, water sequentially add mixing and are reacted, and are heated to 50 DEG C, heat preservation 18
After min, filtering, filtrate is obtained；
S2. the filtrate being obtained by filtration in S1. is ultrasonically treated, supersonic frequency 18kHz, ultrasonic time 17min is obtained
Ultrasonic coupling agent.
A kind of couplant for ultrasound detection of embodiment 4
Composition of raw materials: 28 parts of polyacrylic acid crosslinked compound, 12.5 parts of anemarrhena asphodefoides extract, 10 parts of aloe extract, alginic acid
8 parts of sodium, 145 parts of glycerol, 8 parts of sodium hydroxide, 15 parts of hexylene glycol, 5.5 parts of potassium iodide, 2 parts of ferrous sulfate, ethoxy are fine
Tie up plain 18 parts, 4.5 parts of sodium benzoate, 800 parts of water.
Preparation method:
S1. by CARBOPOL 974P, anemarrhena asphodefoides extract, aloe extract, sodium alginate, glycerol, sodium hydroxide, hexylene glycol, iodate
Potassium, ferrous sulfate, hydroxyethyl cellulose, sodium benzoate, water sequentially add mixing and are reacted, and are heated to 40 DEG C, heat preservation 8
After min, filtering, filtrate is obtained；
S2. the filtrate being obtained by filtration in S1. is ultrasonically treated, supersonic frequency 10kHz, ultrasonic time 10min is obtained
Ultrasonic coupling agent.
A kind of couplant for ultrasound detection of embodiment 5
Composition of raw materials: 28 parts of polyacrylic acid crosslinked compound, 12.5 parts of anemarrhena asphodefoides extract, 10 parts of aloe extract, alginic acid
8 parts of sodium, 145 parts of glycerol, 8 parts of sodium hydroxide, 15 parts of hexylene glycol, 5.5 parts of potassium iodide, 2 parts of ferrous sulfate, ethoxy are fine
Tie up plain 18 parts, 4.5 parts of sodium benzoate, 800 parts of water.
Preparation method:
S1. by CARBOPOL 974P, anemarrhena asphodefoides extract, aloe extract, sodium alginate, glycerol, sodium hydroxide, hexylene glycol, iodate
Potassium, ferrous sulfate, hydroxyethyl cellulose, sodium benzoate, water sequentially add mixing and are reacted, and are heated to 60 DEG C, heat preservation 30
After min, filtering, filtrate is obtained；
S2. the filtrate being obtained by filtration in S1. is ultrasonically treated, supersonic frequency 25kHz, ultrasonic time 30min is obtained
Ultrasonic coupling agent.
Comparative example 1
Comparative example 1 is added to the difference from embodiment 1 is that be added to 10 parts by weight aloe extracts in composition of raw materials less more
10 parts by weight anemarrhena asphodefoides extracts, remaining component and content are identical；The operating procedure of 1 preparation method of comparative example, conditional parameter with
Embodiment 1 is identical.
Comparative example 2
Comparative example 2 add the difference from embodiment 1 is that be added to 12.5 parts by weight anemarrhena asphodefoides extracts in composition of raw materials less more
12.5 parts by weight aloe extracts, remaining component and content are identical；Operating procedure, the condition ginseng of 2 preparation method of comparative example
Number is same as Example 1.
Comparative example 3
Comparative example 3 the difference from embodiment 1 is that be added to 12.5 parts by weight anemarrhena asphodefoides extracts and 10 less in composition of raw materials
Parts by weight aloe extract, is added to 22.5 parts by weight water more, remaining component and content are identical；3 preparation method of comparative example
Operating procedure, conditional parameter are same as Example 1.
Comparative example 4
The ultrasonic coupling agent of certain commercially available brand.
Comparative example 5
Composition of raw materials: 28 parts of polyacrylic acid crosslinked compound, 22.5 parts of commercially available aloe extract (are purchased from Xi'an Chang Yue biology section
Skill Co., Ltd), 8 parts of sodium alginate, 145 parts of glycerol, 8 parts of sodium hydroxide, 15 parts of hexylene glycol, 5.5 parts of potassium iodide, sulphur
Sour ferrous iron 2 parts, 18 parts of hydroxyethyl cellulose, 4.5 parts of sodium benzoate, 800 parts of water.
The operating procedure of 5 preparation method of comparative example, conditional parameter are same as Example 1.
Comparative example 6
Composition of raw materials: 28 parts of polyacrylic acid crosslinked compound, 22.5 parts of commercially available anemarrhena asphodefoides extract (are purchased from Xi'an Chang Yue biology section
Skill Co., Ltd), 8 parts of sodium alginate, 145 parts of glycerol, 8 parts of sodium hydroxide, 15 parts of hexylene glycol, 5.5 parts of potassium iodide, sulphur
Sour ferrous iron 2 parts, 18 parts of hydroxyethyl cellulose, 4.5 parts of sodium benzoate, 800 parts of water.
The operating procedure of 6 preparation method of comparative example, conditional parameter are same as Example 1.
Comparative example 7
Composition of raw materials: 28 parts of polyacrylic acid crosslinked compound, 12.5 parts of commercially available anemarrhena asphodefoides extract (are purchased from Xi'an Chang Yue biology section
Skill Co., Ltd), it is 10 parts of commercially available aloe extract (be purchased from Xi'an Chang Yue Biotechnology Co., Ltd), 8 parts of sodium alginate, sweet
Oily 145 parts, 8 parts of sodium hydroxide, 15 parts of hexylene glycol, 5.5 parts of potassium iodide, 2 parts of ferrous sulfate, hydroxyethyl cellulose 18
Part, 4.5 parts of sodium benzoate, 800 parts of water.
The operating procedure of 7 preparation method of comparative example, conditional parameter are same as Example 1.
The measure of merit of the ultrasonic coupling agent of each embodiment, comparative example:
1. the measurement of acoustic attenuation coefficient: acoustic attenuation is according to the method in GB/T15261 with double sample methods under 35 DEG C and 4.0MHz
Measurement, and be modified with acoustic attenuation in water, the difference of two sample lengths is greater than 5cm.
2. the measurement of bactericidal property: bactericidal property is carried out according to the regulation in GB/T15979-2002 appendix C C.3.
Embodiment 1 ~ 5 and comparative example 1 ~ 4 are applied to ultrasonic probe, sterilization detection is carried out after 3 minutes.
The effect assessment of 1 ultrasonic coupling agent of table
From the data in table 1, it can be seen that the embodiment of the present invention 1 is best-of-breed technology scheme；By the comparison of the present embodiment 1 ~ 3 and embodiment 4,5
It is found that the effect within the scope of conditional parameter of the present invention than outside conditional parameter range than get well；By embodiment 1 ~ 3 with
The comparison of comparative example 1,2 can all cause acoustic attenuation coefficient to become it is found that add aloe extract or anemarrhena asphodefoides extract in raw material less
Small, sterilizing rate decline；From the comparison of embodiment 1 ~ 3 and comparative example 3, it is seen that be added to aloe extract less and rhizoma anemarrhenae extracts
It is even more serious that object will cause the acoustic attenuation coefficient of couplant, sterilizing rate to decline；Embodiment 1 ~ 3 is compared with comparative example 4, function and effect
It to be got well more than general commercially available couplant；Comparative example 1 ~ 2 is respectively compared with comparative example 5 ~ 6, it is seen that is mentioned using general commercially available aloe
Take object, the effect of anemarrhena asphodefoides extract does not use the effect of extract of the present invention good；Embodiment 1, can compared with comparative example 7
See that commercially available aloe extract and anemarrhena asphodefoides extract have no synergistic effect.In conclusion of the present invention for surpassing
The couplant of sound detection not only has fabulous sterilizing ability, and there is the aloe extract and anemarrhena asphodefoides extract in raw material collaboration to increase
The effect of effect, it is nontoxic to human skin, non-stimulated, also it is significantly reduced acoustic attenuation coefficient.
Claims (9)
1. a kind of couplant for ultrasound detection, which is characterized in that be prepared by the raw material comprising following parts by weight: poly- third
It is 18 ~ 37 parts of olefin(e) acid cross-linking compounds, 10 ~ 15 parts of anemarrhena asphodefoides extract, 8 ~ 12 parts of aloe extract, 7 ~ 9 parts of sodium alginate, sweet
Oily 120 ~ 170 parts, 3 ~ 12 parts of sodium hydroxide, 10 ~ 20 parts of hexylene glycol, 3 ~ 7.5 parts of potassium iodide, 0.5 ~ 4.5 part of ferrous sulfate, hydroxyl second
10 ~ 25 parts of base cellulose, 3 ~ 8 parts of sodium benzoate, 650 ~ 950 parts of water.
2. a kind of couplant for ultrasound detection, which is characterized in that be prepared by the raw material comprising following parts by weight: poly- third
25 ~ 30 parts of olefin(e) acid cross-linking compounds, 12 ~ 13 parts of anemarrhena asphodefoides extract, 9 ~ 10 parts of aloe extract, sodium alginate 7.5 ~ 8.5
Part, 140 ~ 150 parts of glycerol, 6 ~ 9 parts of sodium hydroxide, 14 ~ 16 parts of hexylene glycol, 4 ~ 6.5 parts of potassium iodide, ferrous sulfate 1.5 ~
3.5 parts, 15 ~ 20 parts of hydroxyethyl cellulose, 4 ~ 6 parts of sodium benzoate, 750 ~ 850 parts of water.
3. a kind of couplant for ultrasound detection, which is characterized in that be prepared by the raw material comprising following parts by weight: poly- third
28 parts of olefin(e) acid cross-linking compounds, 12.5 parts of anemarrhena asphodefoides extract, 10 parts of aloe extract, 8 parts of sodium alginate, 145 parts of glycerol,
8 parts of sodium hydroxide, 15 parts of hexylene glycol, 5.5 parts of potassium iodide, 2 parts of ferrous sulfate, 18 parts of hydroxyethyl cellulose, sodium benzoate
4.5 parts, 800 parts of water.
4. the couplant according to claim 1 for ultrasound detection, which is characterized in that polyacrylic acid crosslinkedization
Conjunction object is CARBOPOL 974P.
5. being used for the couplant of ultrasound detection described according to claim 1 ~ 3, which is characterized in that the aloe extract
Preparation method comprises the following steps:
S21. by aloe powder, by solid-to-liquid ratio 1(kg): 4 ~ 6(L) hydrochloric acid solution that concentration is 0.5 ~ 0.6mol/L is added, it is put into 70-
In 80 DEG C of water-baths, is filtered after 2 ~ 3h, obtain filtrate；
S22. the filtrate PH in step S1. is adjusted to 7.0, then presses filtrate: 95% ethyl alcohol weight ratio of volume fraction is 1: 6-8, by volume
The ethyl alcohol of score 95% is added in filtrate, stands precipitating completely；
S23. it is centrifuged, 5000 ~ 7000r/min of revolving speed, then time 20-25min is successively washed with ether, dehydrated alcohol, sink
It forms sediment and is freeze-dried, obtain aloe extract.
6. the couplant according to claim 1 to 3 for ultrasound detection, which is characterized in that the rhizoma anemarrhenae extracts
Object the preparation method comprises the following steps:
S31. Common Anemarrhena Rhizome is taken, by solid-to-liquid ratio 1(kg): 30 ~ 60(L) distilled water is added, 1-2 h is extracted at 90-100 DEG C；
S32. it is centrifuged, centrifugation time 4000-5000r/min, 10 ~ 25min of centrifugation time, centrifugate leads to liquid in 30-40ml's
Strongly acidic cation-exchange adjusts pH to 6-6.5, and after being concentrated under reduced pressure at 40 ~ 45 DEG C, rhizoma anemarrhenae is obtained after freeze-drying
Extract.
7. the preparation method described in any one of claim 1 ~ 5 for the couplant of ultrasound detection, which is characterized in that comprising as follows
Step:
S11. by CARBOPOL 974P, anemarrhena asphodefoides extract, aloe extract, sodium alginate, glycerol, sodium hydroxide, hexylene glycol, iodate
Potassium, ferrous sulfate, hydroxyethyl cellulose, sodium benzoate, water sequentially add mixing and are reacted, and after heating, keep the temperature, filtering, obtain
Filtrate；
S12. the filtrate being obtained by filtration in S1. is ultrasonically treated, obtains ultrasonic coupling agent.
8. preparation method according to claim 6, which is characterized in that heating temperature described in S1. is 45 ~ 55 DEG C, heat preservation
Time is 10 ~ 20min.
9. preparation method according to claim 6, which is characterized in that supersonic frequency described in S1. is 15 ~ 20kHz, ultrasound
Time is 15 ~ 20min.
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| CN113198023A (en) * | 2021-04-06 | 2021-08-03 | 常州市武进人民医院 | Coupling agent for ultrasound department and preparation method thereof |
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