CN104888237A - Medical sterilization ultrasound coupling agent and preparation method thereof - Google Patents
Medical sterilization ultrasound coupling agent and preparation method thereof Download PDFInfo
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- CN104888237A CN104888237A CN201510363544.9A CN201510363544A CN104888237A CN 104888237 A CN104888237 A CN 104888237A CN 201510363544 A CN201510363544 A CN 201510363544A CN 104888237 A CN104888237 A CN 104888237A
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- coupling agent
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Abstract
The invention discloses a medical sterilization ultrasound coupling agent and a preparation method thereof and belongs to the field of ultrasound coupling agent. The medical sterilization ultrasound coupling agent has the sterile and sterilizing functions and is prepared through carbomer, glycerine, sodium hydroxide, methyl benzoate, 95% ethanol and purified water. The method includes 1, adding methyl benzoate into 95% ethanol, stirring till dissolving completely, and obtaining a mixed solution A; 2, adding the carbomer, glycerine and mixed solution A into 1000mL purified water, stirring till dissolving completely, standing for 12 hours, and obtaining a mixed solution B; 3, adding the sodium hydroxide into the 1000mL purified water of the temperature of 30 to 40 DEG C, adding into the mixed solution B slowly, stirring for 30 minutes, adding the purified water till 100L, and stirring till being mixed evenly; obtaining the medical sterilization ultrasound coupling agent. The medical sterilization ultrasound coupling agent is applied to operations, ICU, burn and scald, external injury and other sterile environments and human body natural orifice ultrasound operations.
Description
Technical field
The invention belongs to ultrasonic coupling agent field.
Background technology
During ultrasonic examination, the air between probe and patient skin imports obstruction ultrasound wave into human body, and for obtaining high-quality image, need fluidity transmitting medium to connect probe and patient's body surface, this medium is exactly couplant.
First the object of use ultrasonic coupling agent is the slight void between filling contact surface, does not make ultrasonic the penetrating of these interstitial micro-airs impacts; Next is by couplant " transition " effect, the acoustic impedance difference between probe and skin is reduced, thus reduces the reflection loss of ultrasonic energy at this interface.In addition, also play " lubrication " effect, reduce the friction between probe face and skin, probe can be slided flexibly and detect.
The quality of couplant is closely related with the Quality of acoustical image graphic obtained.The couplant of poor quality can make ultrasonic energy losses, and resolving power reduces, image blurring, even chafe and damage probe.
Summary of the invention
The object of this invention is to provide a kind of aseptic, medical ultrasonic coupling agent with disinfective action and preparation method thereof.
For solving the problems of the technologies described above, medical sterilization ultrasonic coupling agent of the present invention is made up of following raw material:
Carbomer: 240 ~ 340g, glycerol: 3000 ~ 4000g, sodium hydroxide: 95 ~ 100g, essence of Niobe: 80 ~ 90g, 95% (volume) ethanol, add to 100L with purified water, the mass ratio of described essence of Niobe and 95% ethanol is (8 ~ 12): 100.
In the present invention, medical sterilization ultrasonic coupling agent is also made up of following raw material:
Carbomer: 340 ~ 440g, glycerol: 4000 ~ 5000g, sodium hydroxide: 100 ~ 110g, essence of Niobe: 100 ~ 110g, 95% (volume) ethanol, add to 100L with purified water, the mass ratio of described essence of Niobe and 95% ethanol is (8 ~ 12): 100.
The preparation method of above-mentioned medical sterilization ultrasonic coupling agent is carried out in the steps below:
Step one, essence of Niobe added in 95% ethanol be stirred to dissolve completely and obtain mixed liquor A;
Step 2, then carbomer, glycerol, mixed liquor A to be added in 1000mL purified water, be stirred to and dissolve completely, leave standstill 12 hours, obtain mixed liquid B;
Step 3, sodium hydroxide is added to temperature is in the 1000mL purified water of 30 ~ 40 DEG C, then slowly adds in mixed liquid B, stirs 30 minutes, then adds purified water and be settled to 100L, is then stirred to mix homogeneously; Namely medical sterilization ultrasonic coupling agent is obtained; Above-mentioned is all room temperature 18 ~ 26 DEG C in steps, and relative humidity 45% ~ 65%, carries out under clean rank 100,000 grades of conditions.
Colourless or the light-coloured transparent gel of product of the present invention, without or have a small amount of bubble, without insoluble foreign body.Product of the present invention is aseptic, has disinfective action; And to mucocutaneous non-stimulated, without sensitization, cytotoxicity 0 grade.Use when the gnotobasiss such as product of the present invention is suitable in Rhizoma Atractylodis Macrocephalae, ICU, burn and scald, wound and human body natural's tract ultrasound procedure.
Method of the present invention is simple, easy to operate.
Detailed description of the invention
Detailed description of the invention one: in present embodiment, medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 350g, glycerol: 5000g, sodium hydroxide: 100g, essence of Niobe: 100g, 95% ethanol, and purified water adds to 100L, the mass ratio of described essence of Niobe and 95% ethanol is 10:100; Its preparation method carries out in the steps below:
Step one, essence of Niobe added in 95% ethanol be stirred to dissolve completely and obtain mixed liquor A;
Step 2, then carbomer, glycerol, mixed liquor A to be added in 1000mL purified water, be stirred to and dissolve completely, leave standstill 12 hours, obtain mixed liquid B;
Step 3, sodium hydroxide is added to temperature is in the 1000mL purified water of 35 DEG C, then slowly adds in mixed liquid B, stirs 30 minutes, then adds purified water and be settled to 100L, is then stirred to mix homogeneously; Namely medical sterilization ultrasonic coupling agent is obtained;
Above-mentioned is all room temperature 25 DEG C in steps, and relative humidity 50%, carries out under clean rank 100,000 grades of conditions.
The performance indications of present embodiment product are in table 1
Table 1
As shown in Table 1, present embodiment product is aseptic, has disinfective action; And to mucocutaneous non-stimulated, without sensitization, cytotoxicity 0 grade.
Detailed description of the invention two: in present embodiment, medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 250g, glycerol: 3200g, sodium hydroxide: 95g, essence of Niobe: 80g, 95% ethanol, and purified water adds to 100L, the mass ratio of described essence of Niobe and 95% ethanol is 8:100.
The medical sterilization ultrasonic coupling agent preparation method of present embodiment is identical with detailed description of the invention one.
The performance indications of present embodiment product are in table 2
Table 2
As shown in Table 2, present embodiment product is aseptic, has disinfective action; And to mucocutaneous non-stimulated, without sensitization, cytotoxicity 0 grade.
Detailed description of the invention three: in present embodiment, medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 300g, glycerol: 3500g, sodium hydroxide: 98g, essence of Niobe: 85g, 95% ethanol, and purified water adds to 100L, the mass ratio of described essence of Niobe and 95% ethanol is 10:100.
The medical sterilization ultrasonic coupling agent preparation method of present embodiment is identical with detailed description of the invention one.
The performance indications of present embodiment product are in table 2
Table 3
As shown in Table 3, present embodiment product is aseptic, has disinfective action; And to mucocutaneous non-stimulated, without sensitization, cytotoxicity 0 grade.
Detailed description of the invention four: in present embodiment, medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 320g, glycerol: 4000g, sodium hydroxide: 100g, essence of Niobe: 90g, 95% ethanol, and purified water adds to 100L, the mass ratio of described essence of Niobe and 95% ethanol is 12:100.
The medical sterilization ultrasonic coupling agent preparation method of present embodiment is identical with detailed description of the invention one.
The performance indications of present embodiment product are in table 4
Table 4
As shown in Table 4, present embodiment product is aseptic, has disinfective action; And to mucocutaneous non-stimulated, without sensitization, cytotoxicity 0 grade.
Detailed description of the invention five: in present embodiment, medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 400g, glycerol: 4500g, sodium hydroxide: 105g, essence of Niobe: 105g, 95% ethanol, and purified water adds to 100L, the mass ratio of described essence of Niobe and 95% ethanol is 9:100.
The medical sterilization ultrasonic coupling agent preparation method of present embodiment is identical with detailed description of the invention one.
The performance indications of present embodiment product are in table 5
Table 5
As shown in Table 5, present embodiment product is aseptic, has disinfective action; And to mucocutaneous non-stimulated, without sensitization, cytotoxicity 0 grade.
Detailed description of the invention six: in present embodiment, medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 440g, glycerol: 5000g, sodium hydroxide: 110g, essence of Niobe: 110g, 95% ethanol, and purified water adds to 100L, the mass ratio of described essence of Niobe and 95% ethanol is 11:100.
The medical sterilization ultrasonic coupling agent preparation method of present embodiment is identical with detailed description of the invention one.
The performance indications of present embodiment product are in table 6
Table 6
As shown in Table 6, present embodiment product is aseptic, has disinfective action; And to mucocutaneous non-stimulated, without sensitization, cytotoxicity 0 grade.
Claims (10)
1. medical sterilization ultrasonic coupling agent, is characterized in that medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 240 ~ 340g, glycerol: 3000 ~ 4000g, sodium hydroxide: 95 ~ 100g, essence of Niobe: 80 ~ 90g, 95% (volume) ethanol, add to 100L with purified water, the mass ratio of described essence of Niobe and 95% ethanol is (8 ~ 12): 100.
2. medical sterilization ultrasonic coupling agent according to claim 1, is characterized in that medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 250g, glycerol: 3200g, sodium hydroxide: 95g, essence of Niobe: 80g, 95% ethanol, and purified water adds to 100L, the mass ratio of described essence of Niobe and 95% ethanol is 8:100.
3. medical sterilization ultrasonic coupling agent according to claim 1, is characterized in that medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 300g, glycerol: 3500g, sodium hydroxide: 98g, essence of Niobe: 85g, 95% ethanol, and purified water adds to 100L, the mass ratio of described essence of Niobe and 95% ethanol is 10:100.
4. medical sterilization ultrasonic coupling agent according to claim 1, is characterized in that medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 320g, glycerol: 4000g, sodium hydroxide: 100g, essence of Niobe: 90g, 95% ethanol, and purified water adds to 100L, the mass ratio of described essence of Niobe and 95% ethanol is 12:100.
5. the preparation method of medical sterilization ultrasonic coupling agent as claimed in claim 1, is characterized in that the preparation method of medical sterilization ultrasonic coupling agent is carried out in the steps below:
Step one, essence of Niobe added in 95% ethanol be stirred to dissolve completely and obtain mixed liquor A;
Step 2, then carbomer, glycerol, mixed liquor A to be added in 1000mL purified water, be stirred to and dissolve completely, leave standstill 12 hours, obtain mixed liquid B;
Step 3, sodium hydroxide is added to temperature is in the 1000mL purified water of 30 ~ 40 DEG C, then slowly adds in mixed liquid B, stirs 30 minutes, then adds purified water and be settled to 100L, is then stirred to mix homogeneously; Namely medical sterilization ultrasonic coupling agent is obtained;
Above-mentioned is all room temperature 18 ~ 26 DEG C in steps, and relative humidity 45% ~ 65%, carries out under clean rank 100,000 grades of conditions.
6. medical sterilization ultrasonic coupling agent according to claim 1, is characterized in that medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 340 ~ 440g, glycerol: 4000 ~ 5000g, sodium hydroxide: 100 ~ 110g, essence of Niobe: 100 ~ 110g, 95% (volume) ethanol, add to 100L with purified water, the mass ratio of described essence of Niobe and 95% ethanol is (8 ~ 12): 100.
7. medical sterilization ultrasonic coupling agent according to claim 6, is characterized in that medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 350g, glycerol: 5000g, sodium hydroxide: 100g, essence of Niobe: 100g, 95% ethanol, and purified water adds to 100L, the mass ratio of described essence of Niobe and 95% ethanol is 10:100.
8. medical sterilization ultrasonic coupling agent according to claim 6, is characterized in that medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 400g, glycerol: 4500g, sodium hydroxide: 105g, essence of Niobe: 105g, 95% ethanol, and purified water adds to 100L, the mass ratio of described essence of Niobe and 95% ethanol is 9:100.
9. medical sterilization ultrasonic coupling agent according to claim 6, is characterized in that medical sterilization ultrasonic coupling agent is made up of following raw material:
Carbomer: 440g, glycerol: 5000g, sodium hydroxide: 110g, essence of Niobe: 110g, 95% ethanol, and purified water adds to 100L, the mass ratio of described essence of Niobe and 95% ethanol is 11:100.
10. the preparation method of medical sterilization ultrasonic coupling agent as claimed in claim 7, is characterized in that the preparation method of medical sterilization ultrasonic coupling agent is carried out in the steps below:
Step one, essence of Niobe added in 95% ethanol be stirred to dissolve completely and obtain mixed liquor A;
Step 2, then carbomer, glycerol, mixed liquor A to be added in 1000mL purified water, be stirred to and dissolve completely, leave standstill 12 hours, obtain mixed liquid B;
Step 3, sodium hydroxide is added to temperature is in the 1000mL purified water of 30 ~ 40 DEG C, then slowly adds in mixed liquid B, stirs 30 minutes, then adds purified water and be settled to 100L, is then stirred to mix homogeneously; Namely medical sterilization ultrasonic coupling agent is obtained;
Above-mentioned is all room temperature 18 ~ 26 DEG C in steps, and relative humidity 45% ~ 65%, carries out under clean rank 100,000 grades of conditions.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105688233A (en) * | 2016-03-10 | 2016-06-22 | 王盛梅 | Medical disinfecting ultrasonic coupling agent |
| CN105832652A (en) * | 2016-05-13 | 2016-08-10 | 沈阳赛镝医疗器械有限公司 | Ultrasonic coupling agent intermediate medium |
| CN109464678A (en) * | 2018-12-10 | 2019-03-15 | 青岛市市立医院 | A kind of ultrasonic coupling agent of lower attenuation coefficient |
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| CN101695576A (en) * | 2009-10-21 | 2010-04-21 | 新余市博源生化医用品有限责任公司 | Medical ultrasonic sterilization couplant |
| CN102178962A (en) * | 2011-04-13 | 2011-09-14 | 枣庄汇康医疗用品有限公司 | Medical disinfection/sterilization ultrasound couplant and preparation method thereof |
| CN102430131A (en) * | 2011-12-06 | 2012-05-02 | 董莉霞 | Antibacterial medical ultrasound compounding agent and preparation method thereof |
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2015
- 2015-06-26 CN CN201510363544.9A patent/CN104888237A/en active Pending
Patent Citations (3)
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| CN101695576A (en) * | 2009-10-21 | 2010-04-21 | 新余市博源生化医用品有限责任公司 | Medical ultrasonic sterilization couplant |
| CN102178962A (en) * | 2011-04-13 | 2011-09-14 | 枣庄汇康医疗用品有限公司 | Medical disinfection/sterilization ultrasound couplant and preparation method thereof |
| CN102430131A (en) * | 2011-12-06 | 2012-05-02 | 董莉霞 | Antibacterial medical ultrasound compounding agent and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105688233A (en) * | 2016-03-10 | 2016-06-22 | 王盛梅 | Medical disinfecting ultrasonic coupling agent |
| CN105832652A (en) * | 2016-05-13 | 2016-08-10 | 沈阳赛镝医疗器械有限公司 | Ultrasonic coupling agent intermediate medium |
| CN109464678A (en) * | 2018-12-10 | 2019-03-15 | 青岛市市立医院 | A kind of ultrasonic coupling agent of lower attenuation coefficient |
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Application publication date: 20150909 |