KR101725311B1 - Water-soluble hydrogel pads composite of the ultrasonic inspection purposes and its production method - Google Patents
Water-soluble hydrogel pads composite of the ultrasonic inspection purposes and its production method Download PDFInfo
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Abstract
Description
The present invention relates to a water-soluble hydrogel pad composition for ultrasonic inspection capable of improving resolution and sharpness of an ultrasound image as an intermediate layer medium during ultrasonic examination and minimizing inconvenience and uncomfortable feeling in use, and a pad manufacturing method using the composition .
Ultrasonography is a method for examining the abnormality of the body tissue using ultrasound. More specifically, the ultrasound is transmitted to a body part to be measured and then the reflected image is acquired as an image to determine whether or not abnormal tissue exists. At present, ultrasound is widely used in most medical examinations, as well as in the diagnosis of lesion tissue or fetus, such as a tumor.
Meanwhile, in order to perform an ultrasonic inspection, an ultrasonic probe which oscillates an ultrasonic wave should be used to apply ultrasonic waves to a desired tissue inside the body. However, the ultrasonic wave is not transmitted properly to the body due to the cause such as attenuation when there is air between the ultrasonic probe and the contact surface of the skin. In other words, at the interface between the air and the skin, the ultrasonic waves are reflected almost 100%, and even if there are very fine bubbles, the propagation of the ultrasonic waves is remarkably reduced, and it becomes very difficult to obtain clear resolution and images.
To solve this problem, an ultrasonic probe is placed on an intermediate material by placing an intermediate coupler between the ultrasonic probe and the surface of the body part. That is, such an intermediate material forms an intermediate layer as an ultrasound transmission medium, thereby minimizing the transmission loss of ultrasonic waves, thereby obtaining a clear image of the tissue.
In general, the mediator uses a product in the form of a liquid gel, which not only discomforts the patient when applied to the surface of the body part, but also, after a certain period of time after the application of the ultrasonic probe, There is a problem that it is inconvenient to continuously use the liquid type gel. In addition, since the ultrasonic probe is still in direct contact with the surface of the body part, the ultrasonic probe may cause an infection problem due to contact in the process of using the ultrasonic probe for many people.
Accordingly, Korean Patent No. 10-0511341 discloses a gel pad for ultrasound including a carrageenan and a method for manufacturing the same, in order to solve the above problems.
The above process comprises the steps of adding 0.1 to 10% by weight of carageenan, 0 to 10% by weight of polyhydric alcohol, and 0.005 to 0.6% by weight of preservative in water and heating and stirring to prepare an aqueous solution; Pouring an aqueous solution of the above step into a tray and holding the aqueous solution at a temperature of 10 to 40 DEG C to form a gel; And a step of packaging the sheet of the above step. This technique is intended to enhance the resolution and clarity of the image.
However, the above technique is produced by cross-linking synthetic polymers, and can not have the same acoustic impedance as water due to the addition of a polymer compound to the water molecule, and the structure of organs in the apparent bend or near field As a result, there is a limit in acquiring clear images and resolution, and there is a problem in that it is inefficient in terms of commercial use because of high manufacturing cost.
Accordingly, the present inventors have intensively studied ultrasonic inspection pads which improve the resolution and sharpness of ultrasound images and have no inconvenience in use. As a result, it has been found that the number of pads made of hydrogel with gelation is high, The present invention has been accomplished on the basis of these findings.
According to the present invention, there is provided a composition comprising: 100 parts by weight of purified water; 0.01 to 0.2 parts by weight of disodium EDTA as an additive, 1.0 to 3.0 parts by weight of 1,2-hexanediol, 0.001 to 0.02 part by weight of sodium hydroxide, ; 5.0 to 20.0 parts by weight of glycerin as a humectant, 5.0 to 15.0 parts by weight of methylpropanediol, 1.0 to 5.0 parts by weight of locust bean gum, 0.1 to 2.0 parts by weight of glucomannan and 0.5 to 3.0 parts by weight of carrageenan as a gum; 0.1 to 2.0 parts by weight of a hydrogenated castor oil (PEG-60) and 0.01 to 0.1 parts by weight of a perfume.
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In addition, the fragrance may or may not include the fragrance.
In the meantime, the method for producing a water-soluble hydrogel pad for ultrasonic inspection according to the present invention comprises the steps of: (1) 0.01 to 0.2 parts by weight of disodium EDTA, 100 parts by weight of 1,2-hexanediol, 1.0 to 3.0 parts by weight of hexanediol, 0.001 to 0.02 part by weight of sodium hydroxide, and stirring them to prepare a first agitated material; (B) 5.0 to 20.0 parts by weight of glycerin, 5.0 to 15.0 parts by weight of methylpropanediol, 1.0 to 5.0 parts by weight of locust bean gum, 0.1 to 2.0 parts by weight of glucomannan and 0.5 to 3.0 parts by weight of carrageenan, and stirring them to prepare a second agitated material; (C) introducing the second agitated product of step (b) into a production tank and heating the product at a temperature of 85 to 95 캜; (D) 0.1 to 2.0 parts by weight of a PEG-60 hydrogenated castor oil and 0.01 to 0.1 parts by weight of a perfume are added to 100 parts by weight of the heated second agitated material in the step (c) Preparing a third agitated product, and defoaming the third agitated product while cooling the agitated product at a temperature of 70 - 80 캜 to maintain a gol form; (E) transferring the third stirred material in the form of a sol of the step (d) to the coater while maintaining the constant temperature of 70-80 占 폚 by using any one of the conveyor or the transfer tank; (3) coating the third agitated material transferred to the coater of step (e) to a thickness of 3 - 5 mm; Preparing a pad by molding the coated third agitated material in the step (a); And a step of packaging the pads in the above step.
Also, 2 to 6 parts by weight of any one selected from purified water or essence may be added to 100 parts by weight of the third agitated product so that the amount of the third agitated product may be increased.
Also, in the above step, the third agitated product is coated through a cooler while maintaining a constant temperature of minus 5 ° C - image 5 ° C, and the pads of the above step are formed into a circular or polygonal shape.
The present invention has gel strength and hardness suitable for use in ultrasound diagnosis, and is relatively long in use due to not being contaminated with fungi and germs, has excellent storability, and uses skin-friendly materials, which is harmless to skin and has excellent moisturizing effect In particular, when the human body part in the apparent bend or the near field is used as an intermediate layer medium in the ultrasound diagnosis and treatment, the resolution and sharpness of the image are excellent.
FIG. 1 is a process diagram showing a method of manufacturing a water-soluble hydrogel pad for ultrasonic inspection according to a preferred embodiment of the present invention.
FIG. 2 is an image of an ultrasonic gel of the prior art taken as an intermediate layer medium. FIG.
3 to 5 are photographs taken with the water-soluble hydrogel pad for ultrasonic inspection according to a preferred embodiment of the present invention as an intermediate layer medium.
6 is a graph showing strength and hardness measured values of a water-soluble hydrogel pad for ultrasonic inspection according to a preferred embodiment of the present invention.
FIG. 7 is a graph showing strength and hardness measured according to the thickness of the gel pad of Example 12, which has the highest strength and hardness in the water-soluble hydrogel pads for ultrasonic inspection according to the preferred embodiment of the present invention.
8 is a graph showing measured values of the water-soluble hydrogel pads for ultrasonic inspection according to a preferred embodiment of the present invention.
FIG. 9 is a photograph showing an ultrasonic wave measurement using a water-soluble hydrogel pad for ultrasonic inspection according to a preferred embodiment of the present invention as an intermediate layer medium on the wrist and the thyroid.
10A to 10C are views showing a shape of a water-soluble hydrogel pad for ultrasonic inspection according to a preferred embodiment of the present invention formed in a circular or polygonal shape.
In the water-soluble hydrogel pad composition for ultrasonic inspection of the present invention,
For 100 parts by weight of purified water;
0.01 to 0.2 parts by weight of disodium EDTA as an additive, 1.0 to 3.0 parts by weight of 1,2-hexanediol, 0.001 to 0.02 part by weight of sodium hydroxide, ;
5.0 to 20.0 parts by weight of glycerin as a humectant, 5.0 to 15.0 parts by weight of methylpropanediol,
1.0 to 5.0 parts by weight of locust bean gum, 0.1 to 2.0 parts by weight of glucomannan and 0.5 to 3.0 parts by weight of carrageenan as a gum;
0.1 to 2.0 parts by weight of a hydrogenated castor oil (PEG-60) and 0.01 to 0.1 parts by weight of a perfume.
The characteristics of the main components of the water-soluble hydrogel pad composition for ultrasonic inspection as described above will be described below.
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1) Disodium EDTA: As an inhibitor of ionic intermolecular coupling, water (metal, etc.) ions generally react when they are reacted for a long time. As a result, disodium EDTA is a component that acts as a preservative.
2) 1,2-hexanediol: It is an organic compound composed of Alpha-lipoic acid, diosgenine, glucosamine and the like, Also, it has high usability with water (purified water) and does not have a large influence on the formulation change, and has a product stabilizing function, a solvent function and a moisturizing function.
3) Sodium hydroxide: It is also called sodium hydroxide (NaOH). It is a representative strong base and has deliquescence which absorbs water vapor in the air and melts by itself. In addition, sodium hydroxide absorbs carbon dioxide (CO 2 ), which, because it melts in water to some extent, can absorb carbon dioxide both in the solid state and in the aqueous state. The sodium hydroxide that absorbs carbon dioxide turns into sodium carbonate.
4) Glycerin: It is a component contained in the fat of plants and animals. It has a high viscosity, and has wettability and unique dissolving power. It is used as a gum, a moisturizer, a booster and a solvent.
5) Methylpropanediol: It is an organic compound as a solvent to dissolve other components. It also assists in skin absorption and delivery of the active and active ingredients.
6) Locust bean gum: white or yellowish white powder with distinctive odor. Locust bean gum is obtained from the carob tree, which is a perennial evergreen bean and perennial plant growing on the Mediterranean coast. The locust bean gum molecule is a chain-like polymer composed mainly of mannose and galactose at a mixing ratio of 4: 1 and has a molecular weight of about 300,000 neutral polysaccharides. It is difficult to dissolve in cold water, but when heated above 60 ℃, it dissolves transparently and becomes a viscous liquid with good water holding capacity. The viscosity of the solution is comparatively stable, but it is easily decayed and the viscosity drops sharply. However, there is a synergistic effect when used with other polysaccharides.
7) Glucomannan: It is contained in orchid plants, old medicinal herbs, irises, grasses, grass roots, and is separated into insoluble copper complexes in a solution extracted by heating with water. β-D-mannopyranose and β-D-glucopyranose are bound in a ratio of 7: 3. In the woody part of gypsum plant, 3 to 5% is also contained, and coexists with cellulose. Holocellulose is pre-treated with 24% potassium hydroxide solution and extracted with 17.5% sodium hydroxide solution containing 4% borates or directly with dimethyl sulfoxide . This polysaccharide has a ratio of D-lactose: D-glucose: D-mannose of 2:10:30 and has an O-acetyl group of 6%. D-mannopyranose and D-glucopyranose (1 → 4) are linked to mannose (1 → 4) by D-galactose in the main chain.
8) Carrageenan: Carrageenan is used as a gelling agent in the present invention, and is a natural high molecular substance produced from the ginseng, red ginseng, etc. of red algae. Carrageenan is a complex polysaccharide extracted from red algae grown in clean waters. It is used as a dispersant, emulsion stabilizer, swelling agent, thickener, binder, dietary fiber, crystallization inhibitor and gelling agent in food applications. In addition to food, applications are expected in medicine, cosmetics and other fields. In general, carrageenan is an anionic polymer having a sulfate group that exhibits strong hydrophilicity and is an anionic polymer having kappa- (kappa-, kappa-), lambda- (lambda, lambda-), iota- -) and mu- (mu, μ -) - furcellaran, and they are commercialized either singly or in combination. Generally, three types of carrageenan, such as kappa, lambda, and iota-type, are mainly used. One of the characteristics of these carrageenans is that they are easily gelated by cations and have excellent film forming ability.
PEG-60 hydrogenated castor oil: Hydrogenated castor oil containing polyethylene oxide in an average of 60 mol of ethylene glycol (polyethylene) glycol derivative, which is used as a surfactant or dissolution aid.
10) xanthan gum: It has excellent heat resistance. In particular, when glacial acetic acid, citric acid, etc. are used, viscosity drop is small even when heated. Natural thickening agents such as xanthan gum are less stable when acidic or alkaline materials coexist. The xanthan gum has no viscosity drop due to pH and is stable even within the pH range of 2 - 13. Xanthan gum has better viscosity than other thickeners and its viscosity gradually increases with concentration.
11) Potassium chloride (potassium chloride): It is obtained from a mineral called sylvite and is a salt component which is an inorganic salt. It is soluble in water and acts as an additive in cosmetics. On the other hand, potassium chloride may be used for patients with electrolyte imbalance as medicines.
On the other hand, the hydrogel pad composition having the above composition is prepared by adding 0.05 part by weight to 1.0 part by weight of an agglomerate of any one or both of xanthan gum and potassium chloride to impart appropriate tackiness And < / RTI >
When the xanthan gum and potassium chloride are mixed, it is preferable that they are mixed at a mixing ratio of 1: 0.1-0.6.
Hereinafter, the method of preparing the hydrogel pads to be formed as described above will be described separately in each step.
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Ⓐ step
(A), 0.01 to 0.2 parts by weight of disodium EDTA, 1.0 to 3.0 parts by weight of 1,2-hexanediol, and 0.01 to 2 parts by weight of sodium hydroxide sodium hydroxide) in an amount of 0.001 to 0.02 part by weight, and stirring them to prepare a first agitated material,
In this step, disodium EDTA, 1,2-hexanediol, and sodium hydroxide are stirred to prepare a first agitated product.
When disodium EDTA is added in an amount of more than 0.2 part by weight based on 100 parts by weight of purified water, the ionic reaction is abruptly increased to affect the properties of the final product, If it is added in an amount of less than 0.01 part by weight, deterioration of the final product can be achieved in a short time.
The 1,2-hexanediol is a component that performs a stabilizing function of the product. If it is added in an amount exceeding 3.0 parts by weight based on 100 parts by weight of purified water, potential toxicity may occur in the final product, By weight, the moisturizing and preservative effect of the final product becomes insignificant.
When sodium hydroxide is added in an amount exceeding 0.02 parts by weight based on 100 parts by weight of purified water, the strength and hardness of the final product are lowered, and 0.001 part by weight , The physical properties of the final product become stiff and the value of the product as a product is lost.
Accordingly, the first agitated product is prepared by mixing 0.01 part by weight to 0.2 part by weight of disodium EDTA, from 1.0 part by weight to 3.0 parts by weight of 1,2-hexanediol per 100 parts by weight of purified water, , And sodium hydroxide in an amount of 0.001 to 0.02 part by weight with stirring.
Ⓑ Step
The step (b) may further comprise, by weight, 5.0 to 20.0 parts by weight of glycerin, 5.0 to 15.0 parts by weight of methylpropanediol, 1.0 to 5.0 parts by weight of locust bean gum, 1.0 to 5.0 parts by weight, 0.1 to 2.0 parts by weight of glucomannan and 0.5 to 3.0 parts by weight of carrageenan, and stirring them to prepare a second agitated product,
In this step, glycerin, methylpropanediol, locust bean gum, glucomannan, and carrageenan are added to the first stirred product followed by stirring to prepare a second agitated product .
The glycerin is a component having high viscosity and wettability and solubility, and when added in an amount exceeding 20.0 parts by weight based on 100 parts by weight of the first agitated product, If it is added in an amount of less than 5.0 parts by weight, drying of the final product proceeds quickly.
Methylpropanediol is an organic compound that affects the dissolution of other constituents. When methylpropanediol is added in an amount exceeding 15.0 parts by weight based on 100 parts by weight of the first agitating material, the physical properties of the final product are hardened, If it is added in an amount of less than 5.0 parts by weight, uniform dissolution with other components is not attained and it is difficult to achieve the intended effect.
If the locust bean gum is added in an amount of more than 5.0 parts by weight based on 100 parts by weight of the first agitated product, the locust bean gum is not easily dissolved in the subsequent heating process, And if it is added in an amount of less than 1.0 part by weight, the final product tends to be spoiled and the viscosity thereof is rapidly lowered.
The above-mentioned glucomannan is a component involved in the formation of a gel, and if it is added in an amount of more than 2.0 parts by weight based on 100 parts by weight of the first agitated product, the final product becomes solidly solidified, The physical properties of the final product are weakened and the product is broken.
The carrageenan is a core component that directly participates in gelation. When the carrageenan is added in an amount exceeding 3.0 parts by weight based on 100 parts by weight of the first agitated product, the final product hardly solidifies, similar to the above-mentioned glucomannan When added in an amount of less than 0.5 parts by weight, the physical properties of the final product are weakened.
Accordingly, the second agitated product is prepared by mixing 5.0 to 20.0 parts by weight of glycerin, 5.0 to 15.0 parts by weight of methylpropanediol, 1.0 to 5.0 parts by weight of locust bean gum, 0.1 part by weight to 2.0 parts by weight of glucomannan, and 0.5 part by weight to 3.0 parts by weight of carrageenan.
Ⓒ Step
The step (c) is a step of putting the second agitated product of step (b) into a production tank and heating it to a temperature of 85 to 95 ° C,
In this step, the second stirred material is heated to a temperature of 85 ° C to 95 ° C in a production tank to form a gel.
Here, if the second agitated material is heated to a temperature outside the range of 85 ° C to 95 ° C, gelation does not proceed, which is undesirable.
Ⓓ Step
The step (d) comprises adding 0.1 to 2.0 parts by weight of a PEG-60 hydrogenated castor oil and 0.01 to 0.1 parts by weight of a perfume to 100 parts by weight of the heated second agitated material in step (c) , And a third agitated material is prepared by agitating the third agitated material and cooling the third agitated material at a temperature of 70 to 80 ° C so as to maintain a gol form,
In this step, the third stirred material may be defoamed while being cooled to a temperature of 70 ° C to 80 ° C so as to maintain the molecular structure of the sol state. Here, when it is cooled above 80 ° C, the viscosity becomes too weak, and when it is cooled below 70 ° C, the viscosity becomes too high, so that the cooling temperature is most preferably 70 ° C to 80 ° C.
On the other hand, the third agitated product is formed by adding PEG-60 hydrogenated castor oil and a flavoring agent to the second agitated product and stirring the mixture. In 100 parts by weight of the second agitated product, When the PEG-60 hydrogenated castor oil is added in an amount exceeding 2.0 parts by weight, the solubility of the active ingredient is drastically increased and the strength and hardness are lowered. When the amount of the hydrogenated castor oil is less than 0.1 part by weight If it is added, the solubility is lowered and the active ingredient is not dissolved uniformly, so that the strength and hardness are lowered.
The fragrance is added to dissipate the fragrance to the product to be perfumed. Preferably, the fragrance is selected from the group consisting of geraniol, vanilla essence, anise oil and lemon oil. And it does not affect the transparency and strength of the product except for the fragrance.
If the fragrance is added in an amount exceeding 0.1 part by weight with respect to 100 parts by weight of the second agitated product, the fragrance may be increased and the fragrance may be uncomfortable to the user.
Accordingly, the third agitated product is preferably formed by stirring 0.1 to 2.0 parts by weight of a hydrogenated castor oil PEG-60 and 0.01 to 0.1 parts by weight of a flavor-60 hydrogenated castor oil.
In addition, 2 to 6 parts by weight of any one selected from purified water or essence may be added to 100 parts by weight of the third agitating material so that the water content can be increased to facilitate the sliding.
Ⓔ Step
The step e) is a step of transferring the third agitated product in the form of a gol of the step d) to a coater through a transfer device (transfer tank)
In this step, the third stirrer formed in the form of a sol is fed through a conveyor (conveyance tank) to the coater for planar coating. At this time, the temperature of the conveyor should be maintained at 70 - 80 ℃. This is maintained at 70 ° C or lower, so gelation starts in the conveyer (transfer tank) at the time of conveyance and can not be coated on a flat surface. Since the viscosity is too low at 80 ° C or higher during transportation, It is not possible to coat them in a plane. Here, the transport device can be applied to the present invention as long as it can perform the transport function.
Step
The above step is a step of coating the transferred third agitated material in phase e, in this case, the thickness of the coating on the plane can be adjusted to 3 - 5 mm and the cooler temperature is maintained at 5 ° C at minus 5 ° C desirable. At this time, when the temperature of the cooler is kept below the range of the temperature, only a part of the gel can be rapidly gelled during gelation, so that the gel can not be gelated. .
Step
In the step (b), the gel coated on the flat surface is molded into a circular or polygonal shape to manufacture a pad,
As shown in Figs. 10A to 10C, the hydrogel pads are formed in various shapes such as circular, triangular, and rectangular shapes, and formed into a coating thickness formed in the step (a). On the other hand, the thickness of the hydrogel pad is most preferably 3.5 mm to 3.7 mm (see Experimental Example 2), because the strength and hardness of the hydrogel are the highest in the thickness range.
Step
The step (a) is a step of packaging the pad of step (b)
In this step, the pads may be packaged and commercialized by various methods including known methods for commercializing the pads after the step. In addition, the product may be subjected to a vacuum sterilization process prior to packaging to ensure its cleanliness.
In addition, 2 to 6 parts by weight of any one selected from purified water or essence may be added to 100 parts by weight of the third agitating material so that the water content can be increased to facilitate the sliding.
On the other hand, the hydrogel pads manufactured through the above steps can be used as an intermediate layer medium by applying to the wrist, thyroid, stomach, ankle, etc., as shown in the photograph shown in Fig.
Hereinafter, the present invention will be described more specifically by way of Examples and Experimental Examples.
[Example] Preparation of water-soluble hydrogel pads for ultrasonic inspection
The additives were added to the purified water and stirred. In the other stirring step, the moisturizing agent and the gum were stirred, and the mixture was put into a production tank. The mixture was heated up to 90 캜, followed by addition of a solubilizing agent and perfume. Then, a circular hydrogel pad was prepared through a defoaming process and a forming process while cooling to 75 ° C.
Here, the additives include disodium EDTA, 1,2-hexanediol, sodium hydroxide, a moisturizing agent such as glycerin, methylpropanediol, And locust bean gum, glucomannan and carrageenan as the gums and PEG-60 hydrogenated castor oil as the solubilizing agent were used. As shown in FIG. 1, the components and the contents contained in Examples 1 to 3 were separately prepared.
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Castor oil
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[Experimental Example 1] Ultrasonic measurement experiment
As the test samples of Experimental Example 1, the hydrogel pads prepared in Examples 1 to 3 were used.
Ultrasonic waves were measured using the hydrogel pads of Examples 1 to 3 as a medium in the thyroid area of a woman. On the other hand, ultrasonic gels generally used in hospitals were used as a control group for comparison with the examples, and ultrasonic waves were measured as a medium in a thyroid area of a woman in the same manner as in the examples. The measurement results are shown in FIG. 2 to FIG. 5, and it can be confirmed that the images of FIG. 3 to FIG. 5 (Examples 1 to 3) are superior to the image of FIG. 2 (control group) in resolution and clarity.
[Experimental Example 2] Gel strength and hardness measurement experiment
In the same manner as in Experimental Example 1, the hydrogel pads prepared in Examples 1 to 3 were set as experimental specimens, and the strength and hardness of the pads set as experimental specimens were measured.
The experimental method was performed by pressing the measurement site (the thyroid area of the woman) using the head of the experimental apparatus at the time of ultrasonic measurement, and the measurement result is shown in FIG.
Referring to the graph shown in FIG. 6, the hydrogel pads of Examples 1 to 3 had strengths of 2840, 3587 and 2847, respectively, and hardnesses of 1002, 1193 and 1030, respectively. It can be confirmed that the hydrogel pads manufactured in Example 2 have higher measured values than the hydrogel pads manufactured in the other examples.
Therefore, the hydrogel pads of Example 2, which showed the highest values in the gel strength and hardness measurement sections, were measured at different thicknesses of the gel (3 mm, 3.7 mm and 4.2 mm). The measurement results are shown in Fig.
Referring to the graph shown in FIG. 7, when the gel thickness was 3 mm, the strength and hardness values were measured to be 2,640 and 907, respectively. When the gel thickness was 3.7 mm, the strength and hardness values were 3,237 and 1090 . When the gel thickness was 4.0 mm, the strength and hardness values were measured as 2,470 and 908, respectively. From the results of measurement as described above, it can be confirmed that the highest strength and hardness are obtained when the thickness of the gel is 3.7 mm.
[Experimental Example 3]
In the same manner as in Experimental Example 1, the hydrogel pads prepared in Examples 1 to 3 were set as experimental specimens, and the yields of the pads set as experimental specimens were measured. The measurement results are shown in FIG.
Referring to the graph shown in FIG. 8, the yields of the gel pads prepared in Examples 1 to 3 were measured to be 6.70%, 5.90%, and 680%, respectively, with respect to the total weight. From the results of measurement as described above, it can be confirmed that the gel pads produced in Example 3 have the highest amount.
As a result, it can be concluded through the above experiments that the hydrogel pads manufactured according to the preferred embodiment of the present invention are excellent in resolution, sharpness, strength and hardness, and in the measurement of water.
Claims (6)
0.01 to 0.2 parts by weight of disodium EDTA as an additive, 1.0 to 3.0 parts by weight of 1,2-hexanediol, 0.001 to 0.02 part by weight of sodium hydroxide, ;
5.0 to 20.0 parts by weight of glycerin as a humectant, 5.0 to 15.0 parts by weight of methylpropanediol,
1.0 to 5.0 parts by weight of locust bean gum, 0.1 to 2.0 parts by weight of glucomannan and 0.5 to 3.0 parts by weight of carrageenan as a gum;
0.1 to 2.0 parts by weight of a hydrogenated castor oil (PEG-60) and 0.01 to 0.1 parts by weight of a perfume. The water-soluble hydrogel pad composition for ultrasonic inspection according to claim 1,
Wherein the perfume is any one selected from the group consisting of geraniol, vanilla essence, anise oil, and lemon oil.
(B) 5.0 to 20.0 parts by weight of glycerin, 5.0 to 15.0 parts by weight of methylpropanediol, 1.0 to 5.0 parts by weight of locust bean gum, 0.1 to 2.0 parts by weight of glucomannan and 0.5 to 3.0 parts by weight of carrageenan, and stirring them to prepare a second agitated material;
(C) introducing the second agitated product of step (b) into a production tank and heating the product at a temperature of 85 to 95 캜;
(D) 0.1 to 2.0 parts by weight of a PEG-60 hydrogenated castor oil and 0.01 to 0.1 parts by weight of a perfume are added to 100 parts by weight of the heated second agitated material in the step (c) Preparing a third agitated product, and defoaming the third agitated product while cooling the agitated product at a temperature of 70 - 80 캜 to maintain a gol form;
(E) transferring the third stirred material in the form of a sol of the step (d) to the coater while maintaining the constant temperature of 70-80 占 폚 by using any one of the conveyor or the transfer tank;
(3) coating the third agitated material transferred to the coater of step (e) to a thickness of 3 - 5 mm;
Preparing a pad by molding the coated third agitated material in the step (a);
And a step of packaging the pads in the step (a).
Wherein 2 to 6 parts by weight of one selected from purified water or essence is further added to 100 parts by weight of the third agitated product in order to increase the yield of the third agitated product in the step A method for manufacturing a hydrogel pad.
In the above step, the third agitated product is coated through a cooler while maintaining a constant temperature of-5 ° C - image 5 ° C,
Wherein the pad of step (c) is formed into a circular or polygonal shape.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101921871B1 (en) | 2018-07-23 | 2018-11-27 | 주식회사 세니피아 | Gel compositions for ultrasound examination and Process for Thereby) |
| KR102137820B1 (en) | 2020-01-30 | 2020-07-24 | 주식회사 에녹 | Gel pad for Ultrasonic wave of musculoskeletal |
| KR102644447B1 (en) * | 2023-06-19 | 2024-03-07 | 주식회사 메디셀 | Hydrogel pad for lasr toning and manufacturing method thereof |
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| KR100318049B1 (en) | 1999-04-12 | 2001-12-22 | 김정식 | Biosonic ultrasound transmission gel |
| KR20030049310A (en) * | 2001-12-14 | 2003-06-25 | 조영재 | Ultrasonic-wave treatment gel used for arthritis treatment apparatus and method for producing the same |
| KR100511341B1 (en) | 2003-05-02 | 2005-08-31 | 한국원자력연구소 | Ultrasonic gel pad containing carrageenan and its preparation |
| KR20080080510A (en) | 2005-11-29 | 2008-09-04 | 타키론 가부시기가이샤 | Gel for ultrasonic phantom |
| KR20120015783A (en) * | 2010-08-13 | 2012-02-22 | 주식회사 셀랩 | A hydrogel composition for transdermal administration of drug |
| KR20140029897A (en) * | 2012-08-31 | 2014-03-11 | 추봉세 | High adhesive hydrogel composition containing lambda carrageenan |
| KR20140069456A (en) * | 2012-11-29 | 2014-06-10 | 주식회사 삼경엠에스엠 | Hydrogel Pack and method of the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100318049B1 (en) | 1999-04-12 | 2001-12-22 | 김정식 | Biosonic ultrasound transmission gel |
| KR20030049310A (en) * | 2001-12-14 | 2003-06-25 | 조영재 | Ultrasonic-wave treatment gel used for arthritis treatment apparatus and method for producing the same |
| KR100511341B1 (en) | 2003-05-02 | 2005-08-31 | 한국원자력연구소 | Ultrasonic gel pad containing carrageenan and its preparation |
| KR20080080510A (en) | 2005-11-29 | 2008-09-04 | 타키론 가부시기가이샤 | Gel for ultrasonic phantom |
| KR20120015783A (en) * | 2010-08-13 | 2012-02-22 | 주식회사 셀랩 | A hydrogel composition for transdermal administration of drug |
| KR20140029897A (en) * | 2012-08-31 | 2014-03-11 | 추봉세 | High adhesive hydrogel composition containing lambda carrageenan |
| KR20140069456A (en) * | 2012-11-29 | 2014-06-10 | 주식회사 삼경엠에스엠 | Hydrogel Pack and method of the same |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101921871B1 (en) | 2018-07-23 | 2018-11-27 | 주식회사 세니피아 | Gel compositions for ultrasound examination and Process for Thereby) |
| KR102137820B1 (en) | 2020-01-30 | 2020-07-24 | 주식회사 에녹 | Gel pad for Ultrasonic wave of musculoskeletal |
| KR102644447B1 (en) * | 2023-06-19 | 2024-03-07 | 주식회사 메디셀 | Hydrogel pad for lasr toning and manufacturing method thereof |
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